-
Targeting ROCK2 improves macromolecular permeability in a 3D fibrotic pancreatic cancer microenvironment model
Reviewed
Hiroyoshi Y. Tanaka, Takuya Nakazawa, Takuya Miyazaki, Horacio Cabral, Atsushi Masamune, Mitsunobu R. Kano
Journal of Controlled Release
369
283
-
295
2024.5
-
Therapeutic Strategies to Overcome Fibrotic Barriers to Nanomedicine in the Pancreatic Tumor Microenvironment.
Invited
Reviewed
International journal
Hiroyoshi Y Tanaka, Takuya Nakazawa, Atsushi Enomoto, Atsushi Masamune, Mitsunobu R Kano
Cancers
15
(
3
)
2023.1
-
Heterotypic 3D pancreatic cancer model with tunable proportion of fibrotic elements
Reviewed
International journal
Hiroyoshi Y. Tanaka, Tsuyoshi Kurihara, Takuya Nakazawa, Michiya Matsusaki, Atsushi Masamune, Mitsunobu R. Kano
Biomaterials
251
120077
-
120077
2020.8
-
Pancreatic stellate cells derived from human pancreatic cancer demonstrate aberrant SPARC-dependent ECM remodeling in 3D engineered fibrotic tissue of clinically relevant thickness
Reviewed
International journal
Hiroyoshi Y. Tanaka, Kentaro Kitahara, Naoki Sasaki, Natsumi Nakao, Kae Sato, Hirokazu Narita, Hiroshi Shimoda, Michiya Matsusaki, Hiroshi Nishihara, Atsushi Masamune, Mitsunobu R. Kano
Biomaterials
192
355
-
367
2019.2
-
Stromal barriers to nanomedicine penetration in the pancreatic tumor microenvironment
Invited
Reviewed
Hiroyoshi Y. Tanaka, Mitsunobu R. Kano
Cancer Science
109
(
7
)
2085
-
2092
2018.7
-
Artificial Intelligence Approach in Machine Learning-Based Modeling and Networking of the Coronavirus Pathogenesis Pathway.
Reviewed
International journal
Shihori Tanabe, Sabina Quader, Ryuichi Ono, Hiroyoshi Y Tanaka, Akihisa Yamamoto, Motohiro Kojima, Edward J Perkins, Horacio Cabral
Current Issues in Molecular Biology
47
(
6
)
2025.6
-
がん微小環境における線維化とナノDDS
Invited
田中 啓祥, 狩野 光伸
Drug Delivery System
36
(
4
)
232
-
240
2021.9
-
Modeling and analysis of disease microenvironments with 3D cell culture technology
Invited
Reviewed
Hiroyoshi Y. Tanaka
Yakugaku Zasshi
141
(
5
)
647
-
653
2021.5
-
三次元培養技術によるがん微小環境のin vitroでの再現とDDS研究への応用
Invited
田中 啓祥, 栗原 毅, 狩野 光伸
Drug Delivery System
35
(
5
)
445
-
447
2020.11
-
Antibiotic prescriptions for Japanese outpatients with acute respiratory tract infections (2013–2015): A retrospective Observational Study
Reviewed
International journal
Toshihiro Koyama, Hideharu Hagiya, Yusuke Teratani, Yasuhisa Tatebe, Ayako Ohshima, Mayu Adachi, Tomoko Funahashi, Yoshito Zamami, Hiroyoshi Y. Tanaka, Ken Tasaka, Kazuaki Shinomiya, Yoshihisa Kitamura, Toshiaki Sendo, Shiro Hinotsu, Mitsunobu R. Kano
Journal of Infection and Chemotherapy
26
(
7
)
660
-
666
2020.7
-
3D in vitro Model of Vascular Medial Thickening in Pulmonary Arterial Hypertension
Reviewed
Chiharu Morii, Hiroyoshi Y. Tanaka, Yasuhisa Izushi, Natsumi Nakao, Masaya Yamamoto, Hiromi Matsubara, Mitsunobu R. Kano, Aiko Ogawa
Frontiers in Bioengineering and Biotechnology
8
2020.5
-
In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers
Reviewed
International journal
Sumiyo Watanabe, Kotaro Hayashi, Kazuko Toh, Hyun Jin Kim, Xueying Liu, Hiroyuki Chaya, Shigeto Fukushima, Keisuke Katsushima, Yutaka Kondo, Satoshi Uchida, Satomi Ogura, Takahiro Nomoto, Hiroyasu Takemoto, Horacio Cabral, Hiroaki Kinoh, Hiroyoshi Y. Tanaka, Mitsunobu R. Kano, Yu Matsumoto, Hiroshi Fukuhara, Shunya Uchida, Masaomi Nangaku, Kensuke Osada, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka
Nature Communications
10
(
1
)
1894
-
1894
2019.12
-
Oral anticoagulants usage in Japanese patients aged 18-74 years with non-valvular atrial fibrillation: A retrospective analysis based on insurance claims data
Reviewed
International journal
Ayako Ohshima, Toshihiro Koyama, Aiko Ogawa, Yoshito Zamami, Hiroyoshi Y. Tanaka, Yoshihisa Kitamura, Toshiaki Sendo, Shiro Hinotsu, Michael W. Miller, Mitsunobu R. Kano
Family Practice
36
(
6
)
685
-
692
2019.12
-
Pattern of antibiotic prescriptions for outpatients with acute respiratory tract infections in Japan, 2013-15: A retrospective observational study
Reviewed
Yusuke Teratani, Hideharu Hagiya, Toshihiro Koyama, Mayu Adachi, Ayako Ohshima, Yoshito Zamami, Hiroyoshi Y. Tanaka, Yasuhisa Tatebe, Ken Tasaka, Naoko Mikami, Kazuaki Shinomiya, Yoshihisa Kitamura, Mitsunobu R. Kano, Shiro Hinotsu, Toshiaki Sendo
Family Practice
36
(
4
)
402
-
409
2019.8
-
Stroma Nanotechnologyを応用したDrug Delivery System
Invited
田中 啓祥, 狩野 光伸
肝・胆・膵
75
(
4
)
805
-
809
2017.10
-
Desmoplastic Reaction in 3D-Pancreatic Cancer Tissues Suppresses Molecular Permeability
Reviewed
International journal
Michiya Matsusaki, Misaki Komeda, Simona Mura, Hiroyoshi Y. Tanaka, Mitsunobu R. Kano, Patrick Couvreur, Mitsuru Akashi
Advanced Healthcare Materials
6
(
15
)
2017.8
-
Regulation of endothelial Fas expression as a mechanism of promotion of vascular integrity by mural cells in tumors
Reviewed
International journal
Ryosuke Kamei, Hiroyoshi Y. Tanaka, Takao Kawano, Chiharu Morii, Sayaka Tanaka, Hiroshi Nishihara, Caname Iwata, Mitsunobu R. Kano
Cancer Science
108
(
5
)
1080
-
1088
2017.5
-
Increased fibrosis and impaired intratumoral accumulation of macromolecules in a murine model of pancreatic cancer co-administered with FGF-2
Reviewed
International journal
Satoshi Sakai, Caname Iwata, Hiroyoshi Y. Tanaka, Horacio Cabral, Yasuyuki Morishita, Kohei Miyazono, Mitsunobu R. Kano
Journal of Controlled Release
230
109
-
115
2016.5
-
Secretions from placenta, after hypoxia/reoxygenation, can damage developing neurones of brain under experimental conditions
Reviewed
International journal
Daniel J. Curtis, Aman Sood, Tom J. Phillips, Akihiro Nishiguchi, Veron H.L. Leinster, Christopher Coyle, Lizeth Lacharme-Lora, Oliver Beaumont, Helena Kemp, Roberta Goodall, Leila Cornes, Michele Giugliano, Rocco A. Barone, Michiya Matsusaki, Mitsuru Akashi, Hiroyoshi Y. Tanaka, Mitsunobu Kano, Jennifer McGarvey, Nagaraj D. Halemani, Katja Simon, Robert Keehan, William Ind, Tracey Masters, Simon Grant, Sharan Athwal, Gavin Collett, Dionne Tannetta, Ian L. Sargent, Emma Scull-Brown, Xun Liu, Kristian Aquilina, Nicki Cohen, Jon D. Lane, Marianne Thoresen, Jon Hanley, Andrew Randall, C. Patrick Case
Experimental Neurology
261
386
-
395
2014.11
