Organization
Faculty of Environmental, Life, Natural Science and Technology Lecturer
Position
Lecturer
External link
OKIHARA Takumi
Degree
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工学博士 ( 京都大学 )
Research Interests
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polymer material
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polymer science
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polysaccharides
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biodegradable polymer
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高分子固体構造
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高分子化学
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機能性高分子
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高分子結晶化
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多糖
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生分解性高分子
Research Areas
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Nanotechnology/Materials / Polymer materials
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Nanotechnology/Materials / Green sustainable chemistry and environmental chemistry
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Nanotechnology/Materials / Organic functional materials
Education
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Kyoto University 工学研究科 高分子化学
- 1991
Country： Japan
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Kyoto University
- 1991
Research History
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- Senior Assistant Professor,Graduate School of Natural Science and Technology,Okayama University
2004
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- 岡山大学自然科学研究科 講師
2004
Professional Memberships
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高分子学会
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米国化学会
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繊維学会
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THE CELLULOSE SOCIETY OF JAPAN
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米国物理学会
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THE JAPAN SOCIETY OF POLYMER PROCESSING
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THE ADHESION SOCIETY OF JAPAN
Committee Memberships
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日本接着学会 評議員
2016.6
Committee type：Academic society
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高分子学会 ポリマー材料フォーラム運営委員
2007 - 2008
Papers
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Multiwall Carbon Nanotube Composites as Artificial Joint Materials Reviewed
Atsushi Sobajima, Takumi Okihara, Shigeaki Moriyama, Naoyuki Nishimura, Takako Osawa, Kazutaka Miyamae, Hisao Haniu, Kaoru Aoki, Manabu Tanaka, Yuki Usui, Ken-ichi Sako, Hiroyuki Kato, Naoto Saito
ACS Biomaterials Science & Engineering 6 ( 12 ) 7032 - 7040 2020.12
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Phosphorylated pullulan as a local drug delivery matrix for cationic antibacterial chemicals to prevent oral biofilm
Naoko Namba-Koide, Yasuhiro Yoshida, Noriyuki Nagaoka, Takumi Okihara, Yusuke Kawata, Masahiro Ito, Takashi Ito, Kazu Takeuchi-Hatanaka, Yuki Shinoda-Ito, Kazuhiro Omori, Tadashi Yamamoto, Shogo Takashiba
BMC ORAL HEALTH 25 ( 1 ) 2025.8
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Development of an Antimicrobial Coating Film for Denture Lining Materials
Kumiko Yoshihara, Takeru Kameyama, Noriyuki Nagaoka, Yukinori Maruo, Yasuhiro Yoshida, Bart Van Meerbeek, Takumi Okihara
PHARMACEUTICS 17 ( 7 ) 2025.7
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Pharmacokinetics and the effectiveness of pyrogen-free bioabsorbable wet adhesives
Risa Oshima, Kumiko Yoshihara, Ko Nakanishi, Tsukasa Akasaka, Shinji Shimoji, Teppei Nakamura, Takumi Okihara, Mariko Nakamura, Akihiro Matsukawa, Ikkei Tamada, Bart Van Meerbeek, Tsutomu Sugaya, Yasuhiro Yoshida
SCIENTIFIC REPORTS 15 ( 1 ) 2025.6
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Innovative submucosal injection solution for endoscopic resection with phosphorylated pullulan: a preclinical study. Reviewed International journal
Takuya Satomi, Yukari Ochi, Takumi Okihara, Hiroki Fujii, Yasuhiro Yoshida, Katsumi Mominoki, Haruko Hirayama, Junki Toyosawa, Yasushi Yamasaki, Seiji Kawano, Yoshiro Kawahara, Hiroyuki Okada, Motoyuki Otsuka, Akihiro Matsukawa
Gastrointestinal endoscopy 99 ( 6 ) 1039 - 1047 2024.6
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Development of phosphate-treated PEEK implants with high osseointegration Reviewed
Yu Usuda, Takumi Okihara, Shigeaki Moriyama, Takeshi Uemura, Takayuki Kamanaka, Aoi William Omi, Naoto Saito, Jun Takahashi, Kaoru Aoki, Naoyuki Nishimura
Materials Today Communications 38 107717 - 107717 2024.3
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Catalytic synthesis and physical properties of CO2-based cross-linked poly(cyclohexene carbonate)s
Chihiro Maeda, Kenta Kawabata, Kaito Niki, Yuma Sako, Takumi Okihara, Tadashi Ema
Polymer Chemistry 2023
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Synthesis of Trimethylene Carbonates and Polycarbonates from Oxetanes and CO2 Using Bifunctional Aluminum Porphyrin Catalysts Reviewed
Chihiro Maeda, Hina Inoue, Ayano Ichiki, Takumi Okihara, Tadashi Ema
ACS Catalysis 12 ( 20 ) 13042 - 13049 2022.10
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Chihiro Maeda, Hina Inoue, Ayano Ichiki, Takumi Okihara, Tadashi Ema
ACS Catalysis 12 ( 20 ) 13042 - 13049 2022.10
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Flame retardance-donated lignocellulose nanofibers (LCNFs) by the Mannich reaction with (amino-1,3,5-triazinyl)phosphoramidates and their properties. Reviewed International journal
Fumiaki Ono, Takumi Okihara, Noboru Osaka, Noriyuki Nagaoka, Yuji Kameoka, Akira Ishikawa, Hironari Ooki, Takumi Ito, Daisuke Todome, Shinya Uemoto, Mitsuaki Furutani, Tsutomu Inokuchi, Kenji Okada
RSC advances 12 ( 6 ) 3300 - 3308 2022.1
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Development of self-adhesive pulp-capping agents containing a novel hydrophilic and highly polymerizable acrylamide monomer Reviewed International coauthorship International journal
Kumiko Yoshihara, Noriyuki Nagaoka, Takumi Okihara, Masao Irie, Akihiro Matsukawa, Mariano Simón Pedano, Yukinori Maruo, Yasuhiro Yoshida, Bart Van Meerbeek
Journal of Materials Chemistry B 8 ( 24 ) 5320 - 5329 2020.5
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Development of self-adhesive pulp-capping agents containing a novel hydrophilic and highly polymerizable acrylamide monomer Reviewed International coauthorship International journal
Kumiko Yoshihara, Noriyuki Nagaoka, Takumi Okihara, Masao Irie, Akihiro Matsukawa, Mariano Simón Pedano, Yukinori Maruo, Yasuhiro Yoshida, Bart Van Meerbeek
Journal of Materials Chemistry B 2020
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Rechargeable anti-microbial adhesive formulation containing cetylpyridinium chloride montmorillonite. Reviewed
Matsuo K, Yoshihara K, Nagaoka N, Makita Y, Obika H, Okihara T, Matsukawa A, Yoshida Y, van Meerbeek B
Acta biomaterialia 2019.9
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Chemical interaction of glycero-phosphate dimethacrylate (GPDM) with hydroxyapatite and dentin. Reviewed International coauthorship International journal
Yoshihara K, Nagaoka N, Hayakawa S, Okihara T, Yoshida Y, Van Meerbeek B
Dental materials : official publication of the Academy of Dental Materials 34 ( 7 ) 1072 - 1081 2018.7
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Preparation of porous carbon material from composite fiber of polyacrylonitrile and cellulose nanofiber
OKIHARA Takumi
Cellulose communications 25 ( 1 ) 15 - 16 2018.1
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Etching efficacy of self-etching functional monomers Reviewed
OKIHARA Takumi
Journal of dental research 0022034518763606 2018
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Effectiveness and stability of silane coupling agent incorporated in 'universal' adhesives. Reviewed
Yoshihara K, Nagaoka N, Sonoda A, Maruo Y, Makita Y, Okihara T, Irie M, Yoshida Y, Van Meerbeek B
Dental materials : official publication of the Academy of Dental Materials 32 ( 10 ) 1218 - 1225 2016.10
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Adsorption and desorption behaviors of cetylpyridinium chloride on hydroxyapatite nanoparticles with different morphologies Reviewed
Masahiro Okada, Daisuke Hiramatsu, Takumi Okihara, Takuya Matsumoto
DENTAL MATERIALS JOURNAL 35 ( 4 ) 651 - 658 2016.8
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Interference of functional monomers with polymerization efficiency of adhesives. Reviewed
Hanabusa M, Yoshihara K, Yoshida Y, Okihara T, Yamamoto T, Momoi Y, Van Meerbeek B
European journal of oral sciences 124 ( 2 ) 204 - 209 2016.4
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Functional monomer impurity affects adhesive performance. Reviewed
Yoshihara K, Nagaoka N, Okihara T, Kuroboshi M, Hayakawa S, Maruo Y, Nishigawa G, De Munck J, Yoshida Y, Van Meerbeek B
Dental materials : official publication of the Academy of Dental Materials 31 ( 12 ) 1493 - 1501 2015.12
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Novel Fluoro-carbon Functional Monomer for Dental Bonding Reviewed
K. Yoshihara, Y. Yoshida, S. Hayakawa, N. Nagaoka, S. Kamenoue, T. Okihara, T. Ogawa, M. Nakamura, A. Osaka, B. Van Meerbeek
JOURNAL OF DENTAL RESEARCH 93 ( 2 ) 189 - 194 2014.2
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Adhesive interfacial interaction affected by different carbon-chain monomers. Reviewed
Yoshihara K, Yoshida Y, Nagaoka N, Hayakawa S, Okihara T, De Munck J, Maruo Y, Nishigawa G, Minagi S, Osaka A, Van Meerbeek B
Dental materials : official publication of the Academy of Dental Materials 29 ( 8 ) 888 - 897 2013.8
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HEMA inhibits interfacial nano-layering of the functional monomer MDP.
Yoshida Y, Yoshihara K, Hayakawa S, Nagaoka N, Okihara T, Matsumoto T, Minagi S, Osaka A, Van Landuyt K, Van Meerbeek B
J Dent Res. 91 1060 - 1065 2012
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吉田 靖弘, 沖原 巧, 長岡 紀幸, 井上 哲, 鳥井 康弘
接着歯学 29 ( 2 ) 90 - 94 2011.8
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TEMPO-Mediated Oxidation of Primary Alcohols to Carboxylic Acids by Exploitation of Ethers in an Aqueous-Organic Biphase System Reviewed
Zhen-Wu Mei, Li-Jian Ma, Hiroyuki Kawafuchi, Takumi Okihara, Tsutomu Inokuchi
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN 82 ( 8 ) 1000 - 1002 2009.8
MISC
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A novel drug controlled release system using phoshorylated polysaccharides
阿部薫明, 沖原巧, 赤坂司, 吉田靖弘
日本歯科理工学会誌 35 ( 2 ) 128 - 128 2016.3
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Bone engineering by phosphorylated-pullulan and beta-TCP composite
Tomohiro Takahata, Takumi Okihara, Yasuhiro Yoshida, Kumiko Yoshihara, Yasuyuki Shiozaki, Aki Yoshida, Kentaro Yamane, Noriyuki Watanabe, Masahide Yoshimura, Mariko Nakamura, Masao Irie, Bart Van Meerbeek, Masato Tanaka, Toshifumi Ozaki, Akihiro Matsukawa
BIOMEDICAL MATERIALS 10 ( 6 ) 065009 2015.12
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多糖誘導体リン酸化プルランをキーマテリアルとした多目的硬組織接着剤の開発
吉田靖弘, 松川昭博, 高柴正悟, 沖原巧, 伊東孝
医科学応用研究財団研究報告 31 23 - 27 2014
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Phosphorylated Pullulan Bioadhesive for Regeneration and Reconstruction of Bone and Tooth
Yasuhiro Yoshida, Takumi Okihara, Mariko Nakamura, Takuya Matsumoto
BIOCERAMICS 24 529-530 516 - + 2013
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The frustrated structure of poly(L-lactide)
J Puiggali, Y Ikada, H Tsuji, L Cartier, T Okihara, B Lotz
POLYMER 41 ( 25 ) 8921 - 8930 2000.12
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Epitaxial crystallization and crystalline polymorphism of polylactides
L Cartier, T Okihara, Y Ikada, H Tsuji, J Puiggali, B Lotz
POLYMER 41 ( 25 ) 8909 - 8919 2000.12
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Facilitated transport of ethyl docosahexaenoate through solution-cast perfluorosulfonated ionomer membranes
H Matsuyama, Y Kitamura, Y Doi, S Ohtsuka, Y Matsuba, T Okihara
JOURNAL OF APPLIED POLYMER SCIENCE 73 ( 6 ) 961 - 968 1999.8
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Frustration and single crystal morphology of isotactic poly(2-vinylpyridine)
T Okihara, L Cartier, GORA van Ekenstein, B Lotz
POLYMER 40 ( 1 ) 1 - 11 1999.1
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Facilitated transport of ethyl docosahexaenoate through solution-cast perfluorosulfonated ionomer membranes
Hideto Matsuyama, Yoshiro Kitamura, Yuji Doi, Shigeru Ohtsuka, Yorishige Matsuba, Takumi Okihara
Journal of Applied Polymer Science 73 ( 6 ) 961 - 968 1999
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Frustration and single crystal morphology of isotactic poly(2-vinylpyridine)
T. Okihara, L. Cartier, G. O.R. Alberda Van Ekenstein, B. Lotz
Polymer 40 ( 1 ) 1 - 11 1999
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The α″ "superstructure" of syndiotactic polystyrene: A frustrated structure
Laurent Cartier, Takumi Okihara, Bernard Lotz
Macromolecules 31 ( 10 ) 3303 - 3310 1998.5
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The α″ "superstructure" of syndiotactic polystyrene: A frustrated structure
Laurent Cartier, Takumi Okihara, Bernard Lotz
Macromolecules 31 ( 10 ) 3303 - 3310 1998.5
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Triangular polymer single crystals: Stereocomplexes, twins, and frustrated structures
Laurent Cartier, Takumi Okihara, Bernard Lotz
Macromolecules 30 ( 20 ) 6313 - 6322 1997.10
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A bimodal structure of solution‐grown isotactic polypropylene with orthogonally crossed lamellae
Isao Masada, Takumi Okihara, Shozo Murakami, Masayoshi Ohara, Akiyoshi Kawaguchi, Ken‐Ichi Katayama
Journal of Polymer Science Part B: Polymer Physics 31 ( 7 ) 843 - 852 1993
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Morphology of Rod-like Polymer Crystals.
Shimamura Kaoru, Okihara Takumi
kenbikyo 28 ( 1 ) 49 - 53 1993
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Crystal Structure of Stereocomplex of Poly(L-lactide) and Poly(D-lactide)
Takumi Okihara, Masaki Tsuji, Akiyoshi Kawaguchi, Ken-Ichi Katayama, Hideto Tsuji, Suong-Hyu Hyon, Yoshito Ikada
Journal of Macromolecular Science, Part B 30 ( 1-2 ) 119 - 140 1991.3
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Epitaxial growth of isotactic polypropylene on oriented polyethylene from solution
Akiyoshi Kawaguchi, Takumi Okihara, Syozo Murakami, Masayoshi Ohara, Ken‐Ichi Katayama, Jürgen Petermann
Journal of Polymer Science Part B: Polymer Physics 29 ( 6 ) 683 - 690 1991
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Substrate-induced crystallization of n-paraffins on oriented polyolefins
Akiyoshi Kawaguchi, Takumi Okihara, Masayoshi Ohara, Masaki Tsuji, Ken-ichi Katayama, Jürgen Petermann
Journal of Crystal Growth 94 ( 4 ) 857 - 870 1989
Presentations
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エチレン‐ビニルアルコール共重合体リン酸化物の生分解性と機能物性
沖原 巧, 黒崎 宗治, 岸本 幸大
第62回高分子と水に関する討論会 2024.12.6
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エチレン-ビニルアルコール共重合体リン酸化物の生分解性と材料物性
沖原 巧, 黒崎 宗治, 岸本 幸大
プラスチック成形加工学会 第32回秋季大会 2024.11.27
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エチレン‐ビニルアルコール共重合体リン酸化物の生分解性と材料物性
沖原 巧, 黒崎 宗治, 岸本 幸大
第３３回ポリマー材料フォーラム 2024.11.15
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変性リン酸化多糖フィルムの薬剤徐放挙動
片岡 秀斗, 北田 亮太, 中村 真理子
第73回高分子討論会 2024.9.26
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エチレン－ビニルアルコール共重合体リン酸化物の生分解
沖原 巧, 黒崎 宗治, 岸本 幸大
第73回高分子討論会 2024.9.25
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超高分子量ポリエチレンと粒界に局在化させたカーボンナノチューブの複合材料の構造物性
麻生悠美子, 沖原 巧, 西村直之, 橋本剛
第７０回高分子研究会 2024.7.12
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リン酸化プルランにおけるリン酸置換度が機能物性に与える影響
高橋明伸, 沖原 巧, 中村真理子
第７０回高分子研究会 2024.7.12
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エチレン‐ビニルアルコール共重合体リン酸化物の生分解性と接着基礎物性
沖原 巧, 黒崎宗治, 岸本幸大
第62回日本接着学会年次大会 2024.6.27
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変性グアーガムを用いた薬剤含有フィルムの作製とその徐放挙動
片岡 秀斗, 沖原 巧, 中村 真理子
第73回高分子学会年次大会 2024.6.6
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エチレン-ビニルアルコール共重合体リン酸化物の溶解特性
沖原 巧, 黒崎 宗治, 岸本 幸大
第73回高分子学会年次大会 2024.6.5
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エチレン‐ビニルアルコール共重合体リン酸化物の生分解性と材料物性
沖原 巧, 黒崎 宗治, 岸本 幸大
プラスチック成型加工学会第31回秋季大会 2023.11.28
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リン酸化プルランを基にした接着型ドラッグデリバリーシステムの徐放メカニズム
沖原 巧, 浅埜 華穂, 中村 真理子
第７2回高分子討論会 2023.9.27
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リン酸化プルランの機能物性に与えるリン酸置換度の影響
高橋 明伸, 沖原 巧, 中村 真理
第７2回高分子討論会 2023.9.27
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グアーガムリン酸化物の薬剤含有フィルムの作製とその徐放挙動
片岡 秀斗, 沖原 巧, 中村 真理子
第７2回高分子討論会 2023.9.27
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エチレン‐ビニルアルコール共重合体リン酸化物の機能物性と生分解性
沖原 巧, 黒崎 宗治, 岸本 幸大
第７2回高分子討論会 2023.9.26
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エチレン―ビニルアルコール共重合体リン酸化物の生分解性と材料化
黒崎 宗治, 岸本 幸大, 沖原 巧
第72回高分子学会年次大会 2023.5.24
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リン酸化プルラン担体の薬剤徐放メカニズムの解明
浅埜 華穂, 沖原 巧
第72回高分子学会年次大会 2023.5.24
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エチレンビニルアルコール共重合体リン酸化物の機能物性.
黒崎 宗治, 岸本幸大, 沖原 巧
第31回ポリマー材料フォーラム 2022.11.16
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カーボンナノチューブを粒界に偏在させた超高分子量ポ リエチレン複合材料の物性
山本大智, 宮前和貴, 沖原 巧
プラスチック成形加工学会第29回秋季大会 2021.11.30 プラスチック成形加工学会
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多層カーボンナノチューブを粒界に局在化させた超高分子量ポリエチレン複合材料の物性評価
山本大智, 宮前和貴, 沖原 巧
第36回中国四国地区高分子若手研究会 2021.11.5 高分子学会中国四国支部
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エチレン-ビニルアルコール共重合体リン酸化物の生分解性評価と機能材料化
黒崎宗治, 沖原 巧, 岸本幸大
第36回中国四国地区高分子若手研究会 2021.11.4 高分子学会中国四国支部
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リン酸化多糖の物性を利用した新規ドラッグデリバリーシステムに関する研究
浅埜華穂, 沖原 巧
第36回中国四国地区高分子若手研究会 2021.11.4 高分子学会中国四国支部
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層間化合物を利用した再充填可能な抗菌剤徐放コーテ ィングの開発
松尾健哉, 亀山武尊, 沖原 巧
第70回高分子討論会 2021.9.6
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モンモリロナイト層間化合物によるリフィル型徐放担体を利用した抗菌コーティング材の開発
松尾健哉, 亀山武尊, 沖原 巧
第59回日本接着学会年次大会 2021.6.24 日本接着学会
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多層カーボンナノチューブを粒界に局在化させた超高分子量ポリエチレンの熱機械物性の評価
山本大智, 宮前和貴, 沖原 巧
第59回日本接着学会年次大会 2021.6.24 日本接着学会
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炭素繊維および多層カーボンナノチューブで強化した PEEK 複合材料の熱および⼒学物性
高 田 善機、沖原 巧、大澤(八木) 恭子、森山 茂章、青木 薫、西村 直之、齋藤 直人
プラスチック成形加工学会第32回年次大会 2021.6.17 プラスチック成形加工学会
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リン酸化プルラン‐界面活性剤複合体からの薬剤徐放メカ ニズムの解明
浅埜華穂, 沖原 巧
第70回高分子学会年次大会 2021.5.28 高分子学会
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エチレンビニルアルコール共重合体リン酸化物の材料物性
黒崎宗治, 岸本幸大, 沖原 巧
第70回高分子学会年次大会 2021.5.27 高分子学会
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炭素系材料の複合的強化による PEEK 複合材の開発
高田善機, 山本大智, 沖原 巧
第70回高分子学会年次大会 2021.5.27 高分子学会
Industrial property rights
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リン酸化プルランの製造方法
沖原 巧
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生体吸収性のシート又はフィルム
吉田 靖弘, 松川 昭博, 沖原 巧
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表面処理された芳香族ポリエーテルエーテルケトンを含むインプラント材料およびその製造方法
沖原 巧，高田善機，斎藤直人，青木 薫，西村直之，羽二生 久夫，森山茂章，上田勝也
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生体吸収性シート又はフィルム
吉田靖弘、松川昭博、沖原 巧
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リン酸化多糖の製造方法
沖原 巧, 亀ノ上 翔吾, 吉田 靖弘, 難波 尚子, 松川 昭博, 長岡 紀幸
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リン酸化多糖の固相合成方法
沖原 巧, 吉田 靖弘, 亀ノ上 翔吾, 木島 菜摘, 井口 勉, 高柴 正悟, 難波 尚子
Awards
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学術賞
2025.6 日本接着学会 リン酸基を導入した高分子材料の接着等の界面物性に関する研究
沖原 巧
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JEMEAベストペーパー賞
2018.1 日本電磁波エネルギー応用学会
沖原 巧
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第21回ポリマー材料フォーラム優秀発表賞
2013 高分子学会
沖原 巧
Research Projects
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薬剤徐放制御を可能にする多重修飾生体吸収性多糖の分子設計
Grant number：23K18597 2023.06 - 2025.03
日本学術振興会 科学研究費助成事業 挑戦的研究(萌芽)
吉原 久美子, 沖原 巧, 長岡 紀幸, 丸尾 幸憲
Grant amount：\6240000 （ Direct expense: \4800000 、 Indirect expense：\1440000 ）
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体内埋植用多糖誘導体の濡れた組織への接着性向上と保存治療系歯学における有効性評価
Grant number：23K09194 2023.04 - 2026.03
日本学術振興会 科学研究費助成事業 基盤研究(C)
中村 真理子, 沖原 巧, 吉田 靖弘
Grant amount：\4680000 （ Direct expense: \3600000 、 Indirect expense：\1080000 ）
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Biodegradability study of phosphorylated poly(ethelene-co-vinyl alcohol)
Grant number：21K05149 2021.04 - 2024.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)
沖原 巧
Grant amount：\4160000 （ Direct expense: \3200000 、 Indirect expense：\960000 ）
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Grant number：17K10930 2017.04 - 2020.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)
TANAKA Masato
Grant amount：\4680000 （ Direct expense: \3600000 、 Indirect expense：\1080000 ）
The phosphorylated pullulan developed by the applicants is a functional polysaccharide derivative that firmly adheres to apatite, which is an inorganic component of living hard tissue. We aimed to develop a film-shaped phosphorylated pullulan that can be expected as a bioadhesive and a carrier for drug delivery, and to combine it with BMP to develop a safe and low-cost bone fusion promoter. The bone formation ability of the rat posterior lateral fixation model was examined, and good bone formation was observed in the BMP-2-added phosphorylated pullulan film group. In this study, phosphorylated pullulan was considered to have extremely low cytotoxicity in bone formation, and could be safely applied clinically.
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Grant number：26293339 2014.04 - 2017.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B) Grant-in-Aid for Scientific Research (B)
Tanaka Masato
Grant amount：\15990000 （ Direct expense: \12300000 、 Indirect expense：\3690000 ）
We investigated the availability of a new bone prosthetic material, which contains an antibacterial agent using phosphorylated-pullulan. Examination was done to measure the sustained release of the antibacterial agent from the bone prosthetic material. The new bone material had greater sustained release abilities compared to conventional bone material. Using an osteomyelitis mouse model, prepared by injecting S. aureus into the mouse bone marrow, we found a significant strong antimicrobial effect compared to conventional bone substitute material. These results suggest that phosphorylated-pullulan represents a drug delivery system for bone tissue, which is effective for preventing infections using an antibacterial agent.
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Development of hard tissue adhesive drug delivery system based on phosphorylated pullulan
Grant number：25410228 2013.04 - 2016.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)
OKIHARA Takumi
Grant amount：\5330000 （ Direct expense: \4100000 、 Indirect expense：\1230000 ）
Hard tissue adhesive drug delivery system based on phosphorylated pullulan has developed. Elucidation of the complex formation mechanism and Control of drug release of phosphorylated pullulan and cationic surfactants was reported. Relationship between complex formation and pH, degree of substitution, ionic-strength indicated that neutralization of charge between phosphate group and cation and hydrophobic interaction has important role in complex formation.
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Crystallization control of topological blend polymer which consists of cyclic polymer as a component
Grant number：24550256 2012.04 - 2015.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
YAMAZAKI Shinichi, KIMURA Kunio, UCHIDA Tetsuya, OKIHARA Takumi, KOBAYASHI Keiko
Grant amount：\5590000 （ Direct expense: \4300000 、 Indirect expense：\1290000 ）
The purpose of this work is to clarify the role of entanglement species on the crystallization of polymers through observation of crystallization of a topological blend polymer which consists of cyclic polymer. Topological blend polymer means the mixing of cyclic and linear polymers. The following issues were investigated. (1) Several kinds of cyclic and linear polyethylene with different molecular weight were prepared. Crystallization at the quiescent state and under the flow were observed by means of polarizing optical microscope. The degree of supercooling, flow rate and strain dependence of the crystallization behavior were made clear. (2) Observation by a scanning electron microscope and crystal structure analysis by wide angle X-ray diffraction measurement were performed for various blends samples.
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Targeting DDS with sensing function of tissular and environmental changes
Grant number：22659357 2010 - 2011
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research
YOSHIDA Yasuhiro, OKIHARA Takumi, NAGAOKA Noriyuki
Grant amount：\3190000 （ Direct expense: \2800000 、 Indirect expense：\390000 ）
We synthesized phosphorylated polysaccharides as the carrier for bactericide delivery. It was indicated that 0. 01% phosphorylated pullulan and 0. 01% cetylpyridinium chloride(CPC) consistently exhibited an antibacterial effect, even after rinsing with distilled water, although CPC at a concentration of 10% showed no effect on bacterial growth after slight rinsing. Furthermore, phosphopullulan exhibited a controllable drug release property for antibacterial and anticancer agents.
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Development of composite membrane of crystalline polymers
Grant number：14550675 2002 - 2004
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)
OKIHARA Takumi
Grant amount：\3500000 （ Direct expense: \3500000 ）
One of the important feature of preparing the composite film, growth mechanism of poly(2-vinyl pyridine) crystal was eluscidated. Precipitation behavior was examined by using various combinations of n-alcohols and hydrocarbons as the mixed solvent. The clouding temperature of polymer solution was examinedas a function of concentration of 1-octanol in the 0.03% P2VP solution in the mixture of 1-octanol and decalin. In higher concentration of 1-octanol in the solvent clouding temperature became higher. Measurement using other combination of alcohol and hydrocarbon for crystallizing solvents resulted in same relationship between clouding temperature and alcohol concentration in the solvent. The results show that the polymer concentration become lower, clouding temperature decrease. This relationship between polymer concentration and clouding temperature indicated that this system showed lower critical solution temperature (LCST) behavior. And this relationship also indicated that this phase separation was not liquid-liquid phase separation but solid-liquid phase separation. This solid-liquid phase separation corresponds to the fact that the morphology of the solution-grown crystal was not spherical shape but platelet. Disturbance of the interface is left for the problem to be solved for preparation of the composite film of two crystalline polymers,
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foldできない高分子鎖の結晶化・結晶欠陥
Grant number：08455457 1996 - 1997
日本学術振興会 科学研究費助成事業 基盤研究(B)
島村 薫, 内田 哲也, 山下 祐彦, 沖原 巧
Grant amount：\7400000 （ Direct expense: \7400000 ）
1.剛直高分子の分子量分別
剛直高分子の結晶化では、結晶から突出した配向ciliaを利用した結晶成長が進むため分子量分布が結晶形態に大きな影響を及ぼす。そのため、まず剛直高分子の分子量分別法を開発した。約40nmより短い分子鎖長領域においてPBZT、PBZOの分別に成功した。
2.分子量分布と結晶形態
分子量分別した試料では分子鎖長が揃えられているため、ciliaを利用した結晶化は起こらず結果的には板状晶となった。未分別試料では長いciliaを利用して多層板状晶、あるいは多数の棒状晶が並列した形態を示した。
3.剛直高分子結晶の表面観察
剛直高分子が板面に対して垂直に配向した板状晶の表面観察を原子間力顕微鏡(AFM)を用いて行った。AFMによる表面観察の結果から、長い分子鎖により形成された一次核を起点として枝状晶が成長し、続いての結晶化により枝状晶間が埋められ菱形の外形となることがわかった。
4.構造異性の結晶化・結晶欠陥に与える影響
従来合成できなかったcis-PBZTを合成し、構造異性体であるtrans-PBZTの固体構造と比較することにより、構造異性が結晶化、結晶欠陥に与える影響を検討した。分子鎖に規則的な湾曲が存在するcis-PBZTでは、分子鎖が分子鎖軸方向に沿って互いにずれた結晶欠陥(axial shift)が減少した。
5.化学構造の結晶化・結晶欠陥に与える影響
化学構造の異なるcis-PBZOの合成、結晶化を行い、化学構造の結晶化・結晶欠陥に与える影響を検討した。 -
Development of super molecular structure during crystallization of rigid rod rod polymers.
Grant number：03403018 1991 - 1993
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for General Scientific Research (A)
SHIMAMURA Kaoru, OKIHARA Takumi, YOKOYAMA Fumiyoshi, KITAMURA Yoshiro
Grant amount：\32500000 （ Direct expense: \32500000 ）
Rigid polymers such as PBZT, PBZO PBPZT and their copolymers were crystallized from dilute solution.
Quenching formed fibribrillar crystals in which polymer chains were paralle to the fibril. These fibrils changed into shish-kebabs by subsequent heat treament in the solvent. lsothermal crystallization gave groups of parallel rodlike crystals of the same length, which appeared like "rafts" on a lake. Molecular chains were oriented normal to the rod crystal. The width of the rod-like crystal were closely related to the avarage molecular length, especially in the molecullar weight region. Due to dispersity in molecular length, many oriented rigid chains were present as cilia on the margin of rod crystals. Primary nuclei were mainly composed of higher molecular weight componebt. At early stage of organization of the rafts, the growing rod-like crystals (mother crystals) accompanied fragmental crystals whose growth rate was much faster that of the mother crystals, because of preliminary supply of the oriented molecular chains from the mother crystals. The differnce in the growth rate finally made all the rod-crystals into the same length within the individual raft. Nucleation density and crystal frowth rate were also measured as functions of temperature and molecular weight.
Crystal structure was investigated using x-rau and a high resoltion electron microscope. Lattice image of the crystal revealed orientational fluctuation and defects within a crystallite. Crystal morphology of isothermally crystallized copolymers were dependent on the composition of the copolymer. ln addition, morphology and structure of branched rigid polymer crystals and also mixd crystals crystallized from blend were discussed.
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