研究者詳細 - 森松　博史

MISC - 森松　博史

分割表示 286 件中 221 - 240 件目／全件表示 >>

急性疾患成人の持続血糖測定の信頼性(原標題は英語)

江木盛時, 森松博史, 戸田雄一郎, 鈴木聡, 溝渕知司, 竹内護, 中塚秀輝, 片山浩, 横山正尚, 森田潔

日本集中治療医学会雑誌 14 ( Supplement ) 303 2007年1月

敗血症性ショックの治療中に好中球減少を併発した1症例

鈴木聡, 森松博史, 江木盛時, 清水一好, 佐藤哲文, 武田吉正, 中塚秀輝, 片山浩, 横山正尚, 森田潔

日本集中治療医学会雑誌 14 ( Supplement ) 257 2007年1月

外科手術後・重症患者の免疫応答能低下のメカニズム末梢血単核球のLPS反応性とCD14,TLR-4.

斎藤信也, 岩垣博巳, 高橋英夫, 勝野剛太郎, 森松博史, 片山浩, 森田潔, 田中紀章

日本外科感染症学会雑誌(1349-5755) 4 ( 2 ) 149 - 156 2007年

【急性血液浄化法のnon-renal indicationの拡大】 High volume hemofiltrationの可能性と限界.

森松博史

ICUとCCU(0389-1194) 31 S60-S62 2007年

RIFLE criteriaにおける尿量の基準の妥当性と有効性に関する検討.

内野滋彦, 森松博史, 上原淳, 間藤卓

日本集中治療医学会雑誌(1340-7988) 14 ( 4 ) 611 - 612 2007年

【集中治療・周術期管理と長期予後】 ICUにおける代謝管理と長期予後.

江木盛時, 森松博史, 片山浩, 森田潔

ICUとCCU(0389-1194) 31 527 - 534 2007年

【急性腎不全の基礎と新たな治療法への期待】 HF-CHDF・HV-CHDF使用の治療戦略.

片山浩, 森松博史, 江木盛時, 佐藤哲文, 森田潔

ICUとCCU(0389-1194) 31 S12-S13 2007年

Stewart Approach 新しい酸塩基平衡の考え方.

森松博史

臨床麻酔(0387-3668) 31 1281 - 1287 2007年

集中治療領域における急性血液浄化法の今後の展望集中治療に役立つ血液浄化の最先端 HF,HV-CHDFに対する期待と展望.

片山浩, 森松博史, 佐藤哲文, 武田吉正, 中塚秀輝, 森田潔

日本臨床麻酔学会誌(0285-4945) 27 ( 1 ) 28 - 33 2007年

Protective role of HO-1 in oxidative tissue injuries

Takahashi, T. Shimizu, H. Inoue, K. *Morimatsu, H. Umeda, K. Omori, E. Akagi, R. Morita, K

Nippon Yakurigaku Zasshi 130, 252-6 ( 4 ) 252 - 256 2007年

記述言語：日本語出版者・発行元：公益社団法人日本薬理学会

昨今の生命科学の進歩は薬理学の研究をより病態に応じた新薬の開発へと向かわせている．しかし，肝不全，腎不全，多臓器不全など，急性臓器不全は高い死亡率を示すにもかかわらず，その治療において決め手となる薬物は未だ開発されていない．これら急性臓器不全の組織障害の病態生理は完全に明らかでないが，好中球の活性化や虚血・再潅流にともなう酸化ストレスによる細胞傷害が大きな役割を果たしている．酸化ストレスはヘムタンパク質からヘムを遊離させる．遊離ヘムは脂溶性の鉄であることから，活性酸素生成を促進して細胞傷害を悪化させる．この侵襲に対抗するために，ヘム分解の律速酵素：Heme Oxygenase-1（HO-1）が細胞内に誘導される．HO-1によるヘム分解反応産物である一酸化炭素，胆汁色素には，抗炎症・抗酸化作用がある．したがって，遊離ヘム介在性酸化ストレスよって誘導されたHO-1は酸化促進剤である遊離ヘムを除去するのみならず，これらの代謝産物の作用を介して細胞保護的に機能する．一方，HO-1の発現抑制やHO活性の阻害は酸化ストレスによる組織障害を悪化させる．この，HO-1の細胞保護作用に着目して，HO-1誘導を酸化ストレスによる組織障害の治療に応用する試みがなされている．本稿では，急性臓器不全モデルにおいて障害臓器に誘導されたHO-1が，遊離ヘム介在性酸化ストレスから組織を保護するのに必須の役割を果たしていることを述べる．また，抗炎症性サイトカイン：インターロイキン11，塩化スズ，グルタミンがそれぞれ，肝臓，腎臓，下部腸管特異的にHO-1を誘導し，これら組織特異的に誘導されたHO-1が標的臓器の保護・回復に重要な役割を果たしていることを示す．HO-1誘導剤の開発は急性臓器不全の新しい治療薬となる可能性を秘めている．<br>

DOI： 10.1254/fpj.130.252

CiNii Article

CiNii Books

researchmap

その他リンク： https://jlc.jst.go.jp/DN/JALC/00300745359?from=CiNii

Stewart Approach : 新しい酸塩基平衡の考え方

森松博史

臨床麻酔 31, 1281-1287 2007年

ﾗｯﾄ出血性ｼｮｯｸ後急性肺傷害に対するｳﾘﾅｽﾀﾁﾝの治療効果.

井上一由, 高橋徹, 井戸佳奈, 清水裕子, 森松博史, 前島亨一朗, 松三昌樹, 片山浩, 森田潔

shock学会雑誌 22 ( 2 ) 96 - 99 2007年

誌上抄読会ﾚﾐﾌｪﾝﾀﾆﾙー本邦での臨床使用に際して最近の話題ー.

溝渕知司, 佐藤健治, 花崎元彦, 中塚秀輝, 大西藍, 大西淳司, 那須敬, 脇有紀, 谷真規子, 金澤伴幸, 鈴木聡, 林真雄

臨床麻酔 31 93 - 100 2007年

腹膜透析を要した小児心臓周術期患者の過血糖(原標題は英語)

江木盛時, 森松博史, 戸田雄一郎, 岩崎達雄, 清水一好, 竹内護, 松崎孝, 鈴木聡, 横山正尚, 森田潔

日本集中治療医学会雑誌 14 ( Supplement ) 2007年

The effects of saline or albumin resuscitation on acid-base status and serum electrolytes

Rinaldo Bellomo, Hiroshi Morimatsu, Craig French, Louise Cole, David Story, Shigehiko Uchino, Toshio Naka

CRITICAL CARE MEDICINE 34 ( 12 ) 2891 - 2897 2006年12月

記述言語：英語出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS

Objective: To test whether fluid resuscitation with normal saline or 4% albumin is associated with differential changes in acid-base status and serum electrolytes.
Design: Nested cohort study.
Setting. Three general intensive care units.
Patients: Six hundred and ninety-one critically ill patients.
Interventions: Randomization of patients to receive blinded solutions of either 4% human albumin or normal saline for fluid resuscitation.
Measurements and Main Results. Albumin was given to 339 patients and saline to 352. At baseline, both groups had a similar serum bicarbonate, albumin, and base excess levels. After randomization, bicarbonate and base excess increased significantly and similarly over time (p <.0001). On multivariate analysis, fluid resuscitation with albumin predicted a smaller increase in pH (p =.0051), bicarbonate (p =.034), and base excess (p =.015). The amount of fluid was an independent predictor of pH (p <.0001), serum chloride (p <.0001), calcium (p =.0001), bicarbonate (p =.0002), and base excess (p <.0001) on the first day of treatment. In patients who received >3 L of fluids in the first 24 hrs, albumin administration was associated with a significantly greater increase in serum chloride (p =.0026). Acute Physiology and Chronic Health Evaluation II score and the presence of sepsis also independently predicted changes in several electrolytes and acid-base variables.
Conclusions. When comparing albumin and saline, the choice and amount of resuscitation fluid are independent predictors of acid-base status and serum electrolytes. When large volumes are given, albumin administration leads to a higher chloride concentration. However, overall differences between the types of fluid are minor, whereas the volume of fluid administered is a much stronger predictor of such changes, which are also influenced by illness severity and the passage of time.

DOI： 10.1097/01.CCM.0000242159.32764.86

Web of Science

researchmap

Effect of low-dose vasopressin infusion on vital organ blood flow in the conscious normal and septic sheep

D. Di Giantomasso, H. Morimatsu, R. Bellomo, C. N. May

ANAESTHESIA AND INTENSIVE CARE 34 ( 4 ) 427 - 433 2006年8月

記述言語：英語出版者・発行元：AUSTRALIAN SOC ANAESTHETISTS

The effect of low-dose vasopressin (AVP) on vital regional circulations may be clinically relevant but has not been fully described. We sought to determine the effect of low-dose AVP on systemic haemodynamics, coronary, mesenteric and renal circulations in the conscious normal and septic mammal.
We studied seven Merino sheep using a prospective randomized cross-over double-blind placebo-controlled animal design. We inserted flow probes around aorta, coronary, mesenteric and renal arteries and, three weeks later, we infused low-dose AVP (0.02 IU/min) or placebo in the normal and septic state induced by intravenous E. coli. In normal sheep, AVP (0. 02 IU/min) induced a 17% decrease in mesenteric blood flow (393.0 +/- 134.9 vs 472.1 +/- 163.8 ml/min, P<0.05) and a 14% decrease in mesenteric conductance (P<0.05). In septic sheep, APT decreased heart rate and cardiac output by 28% and 22%, respectively (P<0.05). It also decreased mesenteric blood flow and mesenteric conductance by 23% (flow: 468.5 +/- 159.7 vs 611.3 +/- 1363 ml/min, P<0.05; conductance: 63 +/- 2.7 vs 8.2 +/- 2.7 ml/min/mmHg; P<0.05). Renal blood flow was unchanged but urine output and creatinine clearance increased (P < 0.05). We conclude that low-dose AVP infusion has similar effects in the normal and septic mammalian circulation: bradycardia, decreased cardiac output, decreased mesenteric blood flow and conductance and increased urine output and creatinine clearance. This information is important to clinicians considering its administration in humans.

Web of Science

researchmap

Hyperchloremic acidosis in the critically ill: One of the strong-ion acidoses?

DA Story, H Morimatsu, R Bellomo

ANESTHESIA AND ANALGESIA 103 ( 1 ) 144 - 148 2006年7月

記述言語：英語出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS

Decreases in plasma bicarbonate are associated with hyperchloremic acidosis and lactic acidosis. According to the Stewart approach to acid-base physiology, the strong-ion difference regulates plasma bicarbonate, with chloride and lactate being the only strong anions routinely measured in clinical chemistry. We hypothesized that the plasma strong-ion difference, both with and without lactate, would have a stronger association with plasma bicarbonate than plasma chloride alone would have with bicarbonate. We used plasma acid-base data from 300 critically ill patients. The correlation with bicarbonate became progressively weaker (P < 0.001): all measured strong ions, r = 0.60; measured strong ions without lactate, r = 0.42; chloride alone, r = -0.27. In a subgroup of 26 patients with traditional hyperchloremic acidosis (base excess < -2mmol/L and anion gap < 17 mmol/L), the measured strong-ion difference (without lactate) had a stronger correlation (P < 0.001) with bicarbonate than chloride had: r = 0.85 versus r = -0.60. We conclude that hyperchloremic acidosis and lactic acidosis are strong-ion acidoses. Hyperchloremia should be viewed relative to the plasma strong cations. A practical conclusion is that both managing and preventing acid-base disorders with IV fluid therapy involves manipulating each of the plasma strong ions, particularly sodium and chloride.

DOI： 10.1213/01.ane.0000221449.67354.52

Web of Science

researchmap

Acid-base balance during continuous veno-venous hemofiltration: The impact of severe hepatic failure

T. Naka, R. Bellomo, H. Morimatsu, J. Rocktaschel, L. Wan, P. Gow, P. Angus

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS 29 ( 7 ) 668 - 674 2006年7月

記述言語：英語出版者・発行元：WICHTIG EDITORE

Background: Continuous renal replacement therapy (CRRT) affects acid-base balance but the influence of severe hepatic failure (SHF) on this effect is unknown.
Aim: To assess the effect of SHF on acid-base balance in patients receiving CVVH.
Design: Retrospective laboratory investigation.
Subjects: Forty patients with SHF and acute renal failure (ARF) treated with CVVH and 42 critically ill patients with severe ARF but no liver disease also treated with CVVH (controls).
Intervention: Retrieval of clinical and laboratory data from prospective unit and laboratory databases.
Methods: Quantitative acid-base status assessment using the Stewart-Figge methodology. Comparison of findings between the two groups.
Results: Although CVVH had a major effect on acid base balance in both groups, patients with SHF had a higher mean lactate concentrations (4.8 vs. 3.1 mmol/L; p < 0.0005), a greater base deficit compared to controls (-1 vs. 4.1 mEq/L; p < 0.0001) and a lower PaCO2 tension (36.8 vs. 42.5 mmHg; p < 0.0001), despite the use of bicarbonate replacement fluid. The acidifying effect of hyperlactatemia was slightly worsened by an increased strong ion gap (9.3 vs. 4.9 mEq/L; p < 0.0001). It was, however, attenuated by an increased strong ion difference apparent (SIDa) (43.6 vs. 41.9 mEq/L; p < 0.05) secondary to hypochloremia (96 vs. 100 mmol/L; p < 0.0001) and by hypoalbuminemia, although hypoalbuminemia in SHF patients (26 vs. 23; p < 0.005) was less pronounced than in controls.
Conclusion: The use of CVVH does not fully correct the independent acidifying effect of liver failure on acid-base status. Increased lactate and strong ion gap values maintain a persistent base deficit despite the alkalinizing effects of hypoalbuminemia and hypochloremia. The correction of acidosis in SHF patients may require more intensive CVVH.

Web of Science

researchmap

General anesthesia in a patient with dystrophic epidermolysis bullosa

Yuichiro Toda, Masataka Yokoyama, Hiroshi Morimatsu, Hideki Nakatsuka, Mamoru Takeuchi, Hiroshi Katayama, Kiyoshi Morita

Journal of Anesthesia 20 ( 2 ) 138 - 140 2006年5月

記述言語：英語

A 13-year-old boy with epidermolysis bullosa underwent a repair of pseudosyndactyly. He had a long history of bullae formation in the oral cavity and on the pharynx and body surface, and some were active at the time of surgery. We chose inhalational general anesthesia with tracheal intubation using sevoflurane and nitrous oxide. The trachea was successfully extubated after the surgery, and no major bulla formation was observed. General anesthesia with tracheal intubation may be chosen as anesthesia for patients with epidermolysis bullosa. © JSA 2006.

DOI： 10.1007/s00540-006-0388-7

Scopus

PubMed

researchmap

Heme arginate pretreatment attenuates pulmonary NF-κB and AP-1 activation induced by hemorrhagic shock via heme oxygenase-1 induction

T. Sasaki, Takatoru Takahashi, H. Shimizu, Y. Toda, H. Morimatsu, M. Takeuchi, M. Yokoyama, R. Akagi, K. Morita

Medicinal Chemistry 2 ( 3 ) 271 - 274 2006年5月

記述言語：英語

Hemorrhagic shock followed by resuscitation (HSR) induces oxidative stress that leads to acute lung injury. Heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme catabolism, is induced by oxidative stress and is thought to play an important role in the protection from oxidative tissue injuries. We previously demonstrated that HO-1 induction by heme arginate (HA), a strong inducer of HO-1, ameliorated HSR-induced lung injury and inflammation. Cellular redox state is known to modulate the DNA biding activity of the transcription factors
nuclear factor-κB (NF-κB) and activator protein-1 (AP-1). In the present study, we treated rats with HA (30 mg/kg of hemin) 18 h prior to HSR and examined its effect on the DNA binding activity of NF-κB and AP-1 at 1.5 h after HSR. HSR significantly increased the DNA binding activity of NF-κB as well as AP-1, while HA pretreatment markedly attenuated the activities of these transcription factors. In contrast, administration of tin mesoporphyrin, a specific competitive inhibitor of HO activity, to HA-pretreated animals abolished the suppressive effect of HA on the activities of NF-κB and AP-1, and increased these activities to almost the same level as those in HSR animals. Our findings indicate that HA pretreatment can significantly suppress the increased activity of NF-κB and AP-1 induced by HSR by virtue of its ability to induce HO-1. Our findings also suggest that HO-1 induced by HA pretreatment ameliorates HSR-induced lung injury at least in part mediated through the suppression of the activities of these transcription factors. © 2006 Bentham Science Publishers Ltd.

DOI： 10.1263/jbb.101.271

<森松 博史>

MISC - 森松 博史

<森松　博史>

MISC - 森松　博史