研究者詳細 - 廣畑　聡

論文 - 廣畑　聡

分割表示 194 件中 161 - 180 件目／全件表示 >>

Serum activin a level is associated with infarct size in patients with acute myocardial infarction who undergo successful primary percutaneous coronary intervention

Toru Miyoshi, Satoshi Hirohata, Tadahisa Uesugi, Minoru Hirota, Hiromichi Ohnishi, Kunio Nogami, Shozo Kusachi, Tohru Ohe

CIRCULATION 116 ( 16 ) 711 - 711 2007年10月

Safety of and tolerance to adenosine infusion for myocardial perfusion single-photon emission computed tomography in a Japanese population

Kunihiko Hatanaka, Masayuki Doi, Satoshi Hirohata, Shigeshi Kamikawa, Yoko Kaji, Tsutomu Katoh, Shozo Kusachi, Yoshifumi Ninomiya, Tohru Ohe

CIRCULATION JOURNAL 71 ( 6 ) 904 - 910 2007年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JAPANESE CIRCULATION SOC

Background Adenosine has been available for use in myocardial perfusion single-photon emission computed tomography (SPECT) in Japan since 2005. The purpose of this study was to evaluate the safety of and tolerance to thallium-201 myocardial perfusion SPECT with intravenous adenosine infusion in Japanese patients with suspected coronary artery disease.
Methods and Results Two hundred and six consecutive patients who underwent an adenosine infusion (120 mu g center dot kg(-1) center dot min(-1)) SPECT at Sumitomo Besshi Hospital (Niihama, Japan) were investigated. The effects of adenosine infusion were monitored for each patient. A coronary angiography was performed in 81 patients. Adenosine infusion significantly decreased blood pressure and increased heart rate. Adverse reactions were observed in 161 patients (78.2%). Most reactions were transient, disappearing soon after the termination of adenosine infusion. No serious adverse reactions, such as acute myocardial infarction or death, occurred. Adenosine infusion was terminated in 3 patients (1.5%) because of near syncope or sustained 2:1 atrioventricular block. Electrocardiographic changes occurred in 15 patients (7.3%). Self-assessed scoring after SPECT showed that the patients were very tolerant (74.6% of 177 patients) of adenosine infusion myocardial SPECT. The sensitivity and specificity were 75.0% and 69.7%, respectively.
Conclusions Adenosine infusion myocardial SPECT is safe and well tolerated in the Japanese population, despite the frequent occurrence of minor adverse reactions.

DOI： 10.1253/circj.71.904

ADAMTS1は内皮細胞特異的に細胞浸潤を抑制する

廣畑聡, 小比賀真就, 小川弘子, 三好亨, Cilek Mehmet Zeynel, Demircan Kadir, Hatipoglu Omer Faruk, 草地省蔵, 二宮善文

日本結合組織学会学術大会・マトリックス研究会大会合同学術集会プログラム・抄録集 39回・54回 134 - 134 2007年5月

がん細胞株におけるADAMTS1の発現レベルの検討

メフメット・ゼネユル・チレッキ, 廣畑聡, カディール・デミルジャン, オメル・ファルク・ハティポール, 小川弘子, 米澤朋子, 草地省蔵, 大橋俊孝, 二宮善文

日本結合組織学会学術大会・マトリックス研究会大会合同学術集会プログラム・抄録集 39回・54回 144 - 144 2007年5月

マウス成長軟骨におけるADAMTS-9発現の検討

熊岸加苗, 西田圭一郎, 百田龍輔, 山合友一朗, 広畑聡, Demircan Kadir, 内藤一郎, 二宮善文, 大塚愛二

解剖学雑誌 82 ( Suppl. ) 150 - 150 2007年3月

Development of an automatic Doppler flow signal detection system: variability of pulmonary and aortic peak flow velocity

Chiho Morita, Takaaki Nakatsu, Shozo Kusachi, Tomoki Kitawaki, Shinichi Usui, Kazuo Tobe, Shinji Toyonaga, Hiroko Ogawa, Satoshi Hirohata, Yasushi Shiratori

JOURNAL OF MEDICAL ULTRASONICS 34 ( 1 ) 37 - 42 2007年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER JAPAN KK

Purpose. Automatic Doppler flow signal detection systems can provide beat-to-beat information for large blood vessels. We have developed new equipment for automatic measurement of Doppler flow signals. The reliability of the system was examined, and the variability of aortic and pulmonary peak flow velocity was determined.
Methods. We measured peak flow velocity using a newly developed system in healthy volunteers and patients with atrial fibrillation. Analysis of variability of peak flow velocity was performed with maximal entropy methods.
Results. In Bland-Altman plots, the mean and standard deviation (SD) of differences in aortic peak flow velocities between the automatic and manual measurements were 0.22 +/- 0.75cm/s and 0.85 +/- 0.38cm/s, respectively, in five normal volunteers. Moreover, less than 5% of the plotted points were beyond 2 SD of the differences. Furthermore, good reproducibility was demonstrated using Bland-Altman plots and Pearson's correlation analysis. Identical reliability was obtained in patients with atrial fibrillation. The same results were obtained for pulmonary peak flow velocity. In five healthy subjects, aortic and pulmonary peak flow showed standard deviations of 7.2 +/- 2.4 and 3.8 +/- 0.6cm/s, respectively, and coefficients of variation of 6.1% +/- 1.0% and +/- 1.1%, respectively, in time-domain variability. Similarly, frequency-domain variability was obtained for both peak flow velocities.
Conclusion. The present study demonstrated the reliability of a newly developed automatic Doppler flow signal detection system. Using this system, the present study demonstrated for the first time aortic and pulmonary peak flow velocity variability. The present analytical methods may have considerable potential for studying aortic and/or pulmonary flow variability in connection with cardiac performance and prognosis of cardiac disease.

DOI： 10.1007/s10396-006-0126-7

Decreased serum levels of interferon gamma inducible protein 10 (IP-10) in acute myocardial infarction patients after successful primary percutaneous coronary intervention are associated with a smaller infarct size

Satoshi Hirohata, Kazuya Koten, Shinichi Usui, Hiroko Ogawa, Hitoshi Yamawaki, Masanari Obika, Mutsurni Iwamoto, Yasushi Shiratori, Shozo Kusachi, Tohru Ohe

CIRCULATION 114 ( 18 ) 744 - 744 2006年10月

The balance of n6/n3 polyunsaturated fatty acid (PUFAs) is an important determinant factor of prognosis after acute myocardial infarction

Takenori Domei, Masayuki Ueeda, Yoichi Takaya, Nobuhiko Ohnishi, Atsushi Takaishi, Masanobu Imai, Satoshi Hirohata, Shozo Kusachi, Toru Ohe

CIRCULATION 114 ( 18 ) 463 - 463 2006年10月

Statin treatment accelerated neovessel formation in the border zone of the infarcted heart: Architectural study of vascular casts by scanning electron microscopy

Mutsumi Iwamoto, Satoshi Hirohata, Masahiko Maruyama, Kunihiko Hatanaka, Hiroko Ogawa, Yasushi Shiratori, Shozo Kusachi, Tohru Ohe

CIRCULATION 114 ( 18 ) 206 - 206 2006年10月

Tumor-specific expression of the RGD-alpha 3(IV)NC1 domain suppresses endothelial tube formation and tumor growth in mice 国際誌

Toru Miyoshi, Satoshi Hirohata, Hiroko Ogawa, Masayuki Doi, Masanari Obika, Tomoko Yonezawa, Yoshikazu Sado, Shozo Kusachi, Satoru Kyo, Seiji Kondo, Yasushi Shiratori, Billy G. Hudson, Yoshifumi Ninomiya

FASEB JOURNAL 20 ( 11 ) 1904 - + 2006年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：FEDERATION AMER SOC EXP BIOL

Angiogenesis plays an essential role in tumor growth. This study investigated expression of the noncollagenous domain of alpha 3(IV) collagen (alpha 3(IV) NC1) transduced into tumors and its inhibition of tumor growth. We hypothesized that if a human telomerase reverse transcriptase (hTERT) promoter-driven RGD motif containing alpha 3(IV) NC1 (hTERT/ RGD-alpha 3(IV) NC1) were expressed in telomerase-expressing tumor cells, it would inhibit tumor growth by its anti-angiogenic property. Adenoviral transduction of hTERT/ RGD-alpha 3(IV) NC1 expressed RGD-alpha 3(IV) NC1 in hTERT-positive tumor cell lines. However, hTERT/ RGD-alpha 3(IV) NC1 did not express RGD-alpha 3(IV) NC1 in hTERT-negative cells such as keratinocytes and fibroblasts. The secreted RGD-alpha 3(IV) NC1 in the conditioned medium from tumor cells inhibited cell proliferation as well as tube formation in cultured endothelial cells, but had no effect on other types of cells. In an in vivo model, adenoviral hTERT/ RGD-alpha 3(IV) NC1 gene therapy showed limited expression of RGD-alpha 3(IV) NC1 in tumors and resulted in a significant decrease of vessel density in tumors. The growth of subcutaneous (s. c.) tumors in nude mice was significantly suppressed by treatment with hTERT/ RGD-alpha 3(IV) NC1. In addition, long-term inhibition of tumor growth was achieved by intermittent administration of hTERT/ RGD-alpha 3(IV) NC1. In conclusion, our findings demonstrate that tumor-specific antiangiogenic gene therapy utilizing RGD-alpha 3(IV) NC1 under the hTERT promoter inhibited angiogenesis in tumors, resulting in an antitumor effect.

DOI： 10.1096/fj.05-5565fje

ヒト末梢血単球成分におけるヒアルロン酸の炎症反応誘導機構の解析

山脇均, 廣畑聡, 小川弘子, 二宮善文, 草地省蔵, 白鳥康史, 大江透

日本動脈硬化学会総会プログラム・抄録集 38回 240 - 240 2006年7月

Coronary pressure measurement to identify the lesion requiring percutaneous coronary intervention in equivocal tandem lesions 国際誌

Minoru Hirota, Kohichiro Iwasaki, Keizo Yamamoto, Shozo Kusachi, Kazuyoshi Hina, Satoshi Hirohata, Masaaki Murakami, Shigeshi Kamikawa, Takashi Murakami, Yasushi Shiratori

CORONARY ARTERY DISEASE 17 ( 2 ) 181 - 186 2006年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS

No reliable methods are available for determining application of percutaneous coronary intervention for treatment of equivocal tandem lesions. We investigated whether coronary pressure measurement is useful for determining the lesion that requires percutaneous coronary intervention in tandem lesions.
We measured coronary pressure in 72 consecutive patients with tandem lesions. Myocardial fractional flow reserve (FFRmyo) was obtained as the ratio of coronary pressure distal to the lesion/aortic pressure under maximal hyperemia. If the FFRmyo across the tandem lesions was >= 0.75, we deferred percutaneous coronary intervention for the lesion. When the tandem lesions showed FFRmyo < 0.75, percutaneous coronary intervention was performed on the lesion that showed angiographically higher stenosis. When FFRmyo was < 0.75 after one-lesion percutaneous coronary intervention, this intervention was carried out on the remaining lesion.
We deferred percuatneous coronary intervention for 26 patients (36.1%), and performed percutaneous coronary intervention in 46 patients (63.8%). We performed percutaneous coronary intervention for one lesion in 19 patients (26.4%) and for both lesions in 27 patients (37.5%). Among patients, in whom percutaneous coronary intervention was deferred, only two patients (7.7%) required target lesion revascularization during the follow-up period. This rate was not higher than that in the 46 patients who underwent percutaneous coronary intervention for one or two lesions (six patients, 13.0%). Similarly, the target lesion revascularization in lesions with initially deferred percuataneous coronary intervention (5.6%, 4/71 lesions) was not higher than that in lesions with percutaneous coronary intervention (15.1%, 11/73 lesions). Major cardiac events, cardiac death and acute myocardial infarction, did not occur in patients with deferred percutaneous coronary intervention during the follow-up period.
Our results clearly showed that coronary pressure measurement was clinically useful for identifying equivocal tandem lesions requiring percutaneous coronary intervention.

DOI： 10.1097/00019501-200603000-00013

Nicorandil reduces the incidence of minor cardiac marker elevation after coronary stenting 国際誌

M Murakami, K Iwasaki, S Kusachi, K Hina, M Hirota, S Hirohata, S Kamikawa, M Sangawa, K Yamamoto, Y Shiratori

INTERNATIONAL JOURNAL OF CARDIOLOGY 107 ( 1 ) 48 - 53 2006年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER IRELAND LTD

Background: Minor cardiac marker elevation after percutaneous coronary intervention has long-term prognostic significance. We examined whether nicorandil, a nicotinamide-nitrate ester, reduces the incidence of minor cardiac marker elevation after coronary stenting.
Methods: Patients (n=192) undergoing coronary stenting were randomly assigned to receive nicorandil (nicorandil group, n=91) or vehicle (control group, n=101). Nicorandil (2 mu g/kg/min, intravenously) was administered immediately after the patients were transfer-red into the catheterization laboratory and continued for 6 h. We measured the serum concentrations of creatine kinase isoenzyme MB (CK-MB) before, immediately after, and 6, 12, and 24 h after the procedure, and those of cardiac troponin T (cTnT) 24 h after the procedure.
Results: There was no significant difference in clinical background between the 2 groups. The nicorandil group showed a significantly lower incidence of CK-MB elevation (> 1 x upper limit of control range, 20 IU/l) than the control group (8.8% vs 21.8%,p < 0.05). The levels of serum CK-MB in the nicorandil group were significantly lower than those in the control group (13.4+5.7 vs 16.5 +/- 9.7 IU/l, p < 0.01). Similarly, the nicorandil group showed a significantly lower incidence of cTnT elevation [> 1 x (0.1 ng/ml) or > 2x (0.2 ng/ml)] upper limit of control range than the control group (14.3% vs 26.7%, p < 0.05, or 7.7% vs 17.8%,p < 0.05). Serum cTnT levels were also significantly lower in the nicorandil group than in the control group (0.05 +/- 0.10 vs 0.15 +/- 0.36 ng/ml, p < 0.05).
Conclusions: The results demonstrated that nicorandil reduces minor cardiac marker elevation after coronary stenting. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.ijcard.2005.02.034

Versican is induced in infiltrating monocytes in myocardial infarction 国際誌

K Toeda, K Nakamura, S Hirohata, OF Hatipoglu, K Demircan, H Yamawaki, H Ogawa, S Kusachi, Y Shiratori, Y Ninomiya

MOLECULAR AND CELLULAR BIOCHEMISTRY 280 ( 1-2 ) 47 - 56 2005年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER

Versican, a large chondroitin sulfate proteoglycan, plays a role in conditions such as wound healing and tissue remodelling. To test the hypothesis that versican expression is transiently upregulated and plays a role in the infarcted heart, we examined its expression in a rat model of myocardial infarction. Northern blot analysis demonstrated increased expression of versican mRNA. Quantitative real-time RT-PCR analysis revealed that versican mRNA began to increase as early as 6 h and reached its maximal level 2 days after coronary artery ligation. Versican mRNA then gradually decreased, while the mRNA of decorin, another small proteoglycan, increased thereafter. Versican mRNA was localized in monocytes, as indicated by CD68-positive staining, around the infarct tissue. The induction of versican mRNA was accelerated by ischemia/reperfusion (I/R), which was characterized by massive cell infiltration and enhanced inflammatory response. To examine the alteration of versican expression in monocytes/macrophages, we isolated human peripheral blood mononuclear cells and stimulated them with granulocyte/macrophage colony-stimulating factor (GM-CSF). Stimulation of mononuclear cells with GM-CSF increased the expression of versican mRNA as well as cytokine induction. The production of versican by monocytes in the infarct area represents a novel finding of the expression of an extracellular matrix gene by monocytes in the infarcted heart. We suggest that upregulation of versican in the infarcted myocardium may have a role in the inflammatory reaction, which mediates subsequent chemotaxis in the infarcted heart.

DOI： 10.1007/s11010-005-8051-4

Coronary pressure measurement to determine treatment strategy for equivocal left main coronary artery lesions

S Suemaru, K Iwasaki, K Yamamoto, S Kusachi, K Hina, S Hirohata, M Hirota, M Murakami, S Kamikawa, T Murakami, Y Shiratori

HEART AND VESSELS 20 ( 6 ) 271 - 277 2005年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER

It is often hard to select a treatment strategy for equivocal left main coronary artery (LMCA) disease. We investigated the usefulness of coronary pressure (CP) measurement for determining the treatment strategy in intermediate LMCA disease. We measured CP in 15 consecutive patients with equivocal LMCA disease (age 67.6 +/- 7.5 years, 14 males). Myocardial fractional flow reserve (FFRmyo) was obtained as the ratio of CP distal to the lesion/aortic pressure under maximal coronary dilation. Patients with FFRmyo >= 0.75 and < 0.75 received medical therapy and coronary artery bypass grafting (CABG), respectively, and were followed up for 32.5 +/- 9.7 (20-47) months. Eight patients received medical therapy and 7 patients underwent CABG in accordance with the FFRmyo criteria noted above. FFRmyo of the LMCA was 0.91 +/- 0.01 and 0.61 +/- 0.03 in patients who received medical and surgical therapy, respectively. Neither reference vessel diameter, minimal lumen diameter, nor percent diameter stenosis was significantly different between patients who received medical and surgical therapy. During the follow-up period, no patients with medical therapy showed symptoms due to the LMCA lesion. Similarly, 5 of 7 patients with CABG showed improvement of symptoms and the remaining 2 patients were hospitalized with congestive heart failure. No cardiac death was recorded in the patients with medical or surgical therapy. In conclusion, the present results clearly demonstrated that CP is clinically useful for determining the treatment strategy for equivocal LMCA lesions but coronary angiography is not.

DOI： 10.1007/s00380-005-0849-1

Frequent deletion and down-regulation of ING4, a candidate tumor suppressor gene at 12p13, in head and neck squamous cell carcinomas 国際誌

M Gunduz, H Nagatsuka, K Demircan, E Gunduz, B Cengiz, M Ouchida, H Tsujigiwa, E Yamachika, K Fukushima, L Beder, S Hirohata, Y Ninomiya, K Nishizaki, K Shimizu, N Nagai

GENE 356 ( 1-2 ) 109 - 117 2005年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER SCIENCE BV

We previously showed two members of the ING family, ING1 and ING3 as a tumor suppressor gene in head and neck cancer. Progress in human genome sequencing provided additional information of the new members of the ING family genes. ING4 is localized to chromosome 12p13.31 region and harbors the PHD domain highly homologous among ING family proteins. We analyzed loss of heterozygosity at 12p12-13 region in 50 head and neck squamous cell carcinomas by using six highly polymorphic microsatellite markers and found allelic loss in 66% (33/50) of the informative cases. To clarify the role of ING4 in head and neck carcinogenesis, we first checked mutation status in tumor samples. As mutation of the ING4 gene was not found in head and neck cancers, we examined the mRNA expression level. Quantitative real-time RT-PCR analysis demonstrated decreased expression of ING4 mRNA in 76% of primary tumors as compared with that of matched normal samples. Since p53 dependent pathways of other ING family members have been shown, we examined p53 mutation status and compared with ING4 mRNA expression in tumor samples. However, no such direct relationship has been detected. In conclusion, frequent deletion and decreased mRNA expression of ING4 suggested it as a class two tumor suppressor gene and may play an important role in head and neck cancer. (c) 2005 Elsevier B.V. All rights reserved.

DOI： 10.1016/j.gene.2005.02.014

バーシカンはラット心筋梗塞において一時的に上昇し,その発現は再灌流傷害により増強する

廣畑聡, 小川弘子, 山脇均, 小比賀真就, 草地省蔵, 白鳥康史, 大江透, 二宮善文

日本動脈硬化学会総会プログラム・抄録集 37回 197 - 197 2005年7月

Significant correlation of recruitable coronary collateral blood flow determined by coronary wedge pressure with ST-segment elevation during coronary occlusion 国際誌

S Karnikawa, K Iwasaki, K Yamamoto, S Kusachi, K Hina, S Hirohata, M Murakami, M Hirota, T Murakami, Y Shiratori

CORONARY ARTERY DISEASE 16 ( 4 ) 231 - 236 2005年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS

Objectives Quantitative assessment of coronary collateral blood flow can be archived by measuring coronary pressure. We studied the relationships between recruitable coronary collateral blood flow and electrocardiographic changes during percutaneous coronary intervention (PCI).
Methods We measured coronary pressure during coronary occlusion with PCI in 119 patients with left anterior descending coronary artery stenosis. During balloon inflation, the electrocardiogram was continuously recorded. The ST-segment elevation in the most elevated lead was defined as MaxST and the sum of the maximal ST elevation in leads V2-V4 was defined as Sigma ST. Fractional collateral flow (Qc/Q(N)) was calculated as the coronary wedge pressure divided by the mean aortic pressure. Myocardial ischemia was defined as an ST-segment shift > 0.1 mV in any of the V2, V3 or V4 leads.
Results A significant relationship between Qc/Q(N) and MaxST was observed (r= -0.455, P < 0.0001). Similarly, Qc/Q(N) was significantly correlated with Sigma ST (r= - 0.477, P < 0.0001). The receiver operating characteristic curve showed that a cut-off value of 0.27 for Qc/Q(N), with sensitivity of 71.4% and specificity of 76.2%, was an indicator of electrophysiologically sufficient recruitable coronary collateral blood flow for prevention of ischemia during coronary obstruction. Qc/Q(N) values during the first, second, third and fourth inflation were not significantly different.
Conclusions Qc/Q(N) could be clinically useful for determining whether there is electrophysiologically sufficient recruitable coronary collateral blood flow for prevention of ischemia during coronary obstruction. Repeat transient coronary occlusion during PCI did not lead to increased collateral blood flow. (c) 2005 Lippincott Williams & Wilkins.

DOI： 10.1097/00019501-200506000-00004

5) Identification and Characterization of a novel rat link protein gene : Lp3/Hapln3(第84回日本循環器学会中国地方会)

小川弘子, 廣畑聡, 三好亨, 村上充, 白鳥康史, 大橋俊孝, 二宮善文, 草地省蔵, 佐田政隆

Circulation journal : official journal of the Japanese Circulation Society 68 ( 0 ) 938 - 938 2004年10月

Dynamic induction of ADAMTS1 gene in the early phase of acute myocardial infarction 国際誌

K Nakamura, S Hirohata, T Murakami, T Miyoshi, K Demircan, T Oohashi, H Ogawa, K Koten, K Toeda, S Kusachi, Y Ninomiya, Y Shiratori

JOURNAL OF BIOCHEMISTRY 136 ( 4 ) 439 - 446 2004年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JAPANESE BIOCHEMICAL SOC

Extracellular matrix (ECM)-degrading enzymes such as matrix metalloproteases (MMPs) play an essential role in the repair of infarcted tissue, which affects ventricular remodeling after myocardial infarction. ADAMTS1 (A disintegrin and metalloprotease with thrombospondin motifs), a newly discovered metalloprotease, was originally cloned from a cancer cell line, but little is known about its contribution to disease. To test the hypothesis that ADAMTS1 appears in infarcted myocardial tissue, we examined ADAMTS1 mRNA expression in a rat myocardial infarction model by Northern blotting, real-time RT-PCR and in situ hybridization. Normal endothelium expressed little ADAMTS1 mRNA, while normal myocardium expressed no detectable ADAMTS1 mRNA. Up-regulation of ADAMTS1 was demonstrated by Northern blot analysis and real-time RT-PCR at 3 h after coronary artery ligation. In situ hybridization revealed strong ADAMTS1 mRNA signals in the endothelium and myocardium in the infarcted heart, mainly in the infarct zone, at 3 h after myocardial infarction. The rapid and transient up-regulation of the ADAMTS1 gene in the ischemic heart was distinct from the regulatory patterns of other MMPs. Our study demonstrated that the ADAMTS1 gene is a new early immediate gene expressed in the ischemic endothelium and myocardium.

DOI： 10.1093/jb/mvh138

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論文 - 廣畑 聡

<廣畑　聡>

論文 - 廣畑　聡