研究者詳細 - 廣畑　聡

論文 - 廣畑　聡

分割表示 194 件中 141 - 160 件目／全件表示 >>

Augmentation index is associated with B-type natriuretic peptide in patients with paroxysmal atrial fibrillation 国際誌

Youko Kaji, Toru Miyoshi, Masayuki Doi, Satoshi Hirohata, Shigeshi Kamikawa, Kosuke Sakane, Tomoki Kitawaki, Shozo Kusachi, Kengo Fukushima Kusano, Hiroshi Ito

HYPERTENSION RESEARCH 32 ( 7 ) 611 - 616 2009年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：NATURE PUBLISHING GROUP

B-type natriuretic peptide (BNP) levels have been shown to be elevated in patients with paroxysmal atrial fibrillation (PAF); however, the underlying mechanisms have not been fully elucidated. Earlier, we reported that an increase in the augmentation index ( AI), which is an index of wave reflection and arterial stiffness, is associated with PAF. In this study, we investigate the relationship between the BNP level and AI in patients with PAF. We enrolled 92 patients with a history of PAF and 90 age- and gender-matched individuals without PAF. AI was calculated using applanation tonometry of the radial artery when all patients were on sinus rhythm. Plasma BNP levels were measured simultaneously. An arterial stiffness parameter, the cardio-ankle vascular index ( CAVI), was also evaluated. The increased AI in patients with PAF correlated with the elevation of the BNP level (r=0.47, P<0.01). When PAF patients were classified into tertiles on the basis of the BNP level, the left atrial volume index, left ventricular mass index, AI and CAVI increased, and mitral annular e' velocity (e'), as an index of left ventricular diastolic pressure, decreased with BNP tertiles. AI was also associated with e' and left ventricular mass index. Multiple regression analysis showed that the AI in PAF patients independently correlated with BNP levels. This study showed that AI was an independent correlate of the BNP level in PAF patients. Left ventricular diastolic dysfunction, which linked to an increase in arterial stiffness, may be involved in the elevated BNP level. Hypertension Research ( 2009) 32, 611-616; doi: 10.1038/hr.2009.62; published online 1 May 2009

DOI： 10.1038/hr.2009.62

IDENTIFICATION OF NF-kappa B BINDING ELEMENTS IN HUMAN ADAMTS9 PROMOTER

Kadir Demircan, Esra Gunduz, Mehmet Zeynel Cilek, Omer Faruk Hatipoglu, Kursat Oguz Yaykasli, Mehmet Gunduz, Yoshifum Ninomiya, Satoshi Hirohata

IUBMB LIFE 61 ( 3 ) 354 - 354 2009年3月

Relationship between activin A level and infarct size in patients with acute myocardial infarction undergoing successful primary coronary intervention 国際誌

Toru Miyoshi, Satoshi Hirohata, Tadahisa Uesugi, Minoru Hirota, Hirornichi Ohnishi, Kunio Nogami, Kunihiko Hatanaka, Hiroko Ogawa, Shinichi Usui, Shozo Kusachi

CLINICA CHIMICA ACTA 401 ( 1-2 ) 3 - 7 2009年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER SCIENCE BV

Background: Activin A, a member of the transforming growth factor-beta cytokine family, has been suggested to have a role in inflammation. We examined the serum level of activin A in patients with acute myocardial infarction (AMI) undergoing successful primary percutaneous coronary intervention (PCI).
Methods: The subjects were 30 AMI patients, 20 stable angina pectoris (AP) patients and 20 normal subjects. The serum levels of activin A in AMI patients were measured before PCI and on days 1, 2, 7, and 14.
Results: Activin A levels before PCI in AMI patients (557 +/- 255 pg/ml) showed a significantly higher value than those in AP patients (364 +/- 159 pg/ml) and control subjects (316 +/- 144 pg/ml). Increased serum activin A level before PCI was decreased on day 2, and then gradually re-elevated on days 7 and 14, The serum activin A level before PCI was correlated with log-transformed peak creatine kinase (CK) as a surrogate of infarct size (r=0.48, p=0.008). Stepwise multiple regression analysis demonstrated that the serum activin A level before PCI was an independent predictor of peak CK.
Conclusions: The serum activin A level, increased in AMI, was positively correlated with peak CK and CK-MB levels which are measures of infarction size. (C) 2008 Elsevier B.V. All rights reserved.

DOI： 10.1016/j.cca.2008.10.027

THE 3 '-UNTRANSLATED REGION OF THE ADAMTS1 REGULATES ITS EXPRESSION

Omer Faruk Hatipoglu, Satoshi Hirohata, Kursat Oguz Yaykasli, Mehmet Zeynel Cilek, Kadir Demircan, Ryoko Shinohata, Shozo Kusachi, Yoshifumi Ninomiya

IUBMB LIFE 61 ( 3 ) 367 - 367 2009年3月

UTILIZATION OF ADAMTSI AS A NEW TOOL FOR DETECTING HYPOXIA

Mehmet Zeynel Cilek, Satoshi Hirohata, Omer Faruk Hatipoglu, Kadir Demircan, Junko Inagaki, Tomoko Yonezawa, Toshikata Oohashi, Yoshifumi Ninomiya

IUBMB LIFE 61 ( 3 ) 357 - 358 2009年3月

ADAMTS1の血管新生阻害機能の解析血管内皮細胞に対する影響

高橋克之, 廣畑聡, 小比賀真就, 三好亨, 小川弘子, 草地省蔵, 二宮善文

日本薬学会年会要旨集 129年会 ( 3 ) 218 - 218 2009年3月

マウス成長軟骨におけるADAMTS-9発現とその役割について

熊岸加苗, 西田圭一郎, 百田龍輔, 山合友一朗, 廣畑聡, Kadir Demircan, 内藤一郎, 二宮善文, 大塚愛二

解剖学雑誌 84 ( Suppl. ) 139 - 139 2009年3月

Hyaluronan receptors involved in cytokine induction in monocytes 査読国際誌

Hitoshi Yamawaki, Satoshi Hirohata, Toru Miyoshi, Katsuyuki Takahashi, Hiroko Ogawa, Ryoko Shinohata, Kadir Demircan, Shozo Kusachi, Kazuhide Yamamoto, Yoshifumi Ninomiya

GLYCOBIOLOGY 19 ( 1 ) 83 - 92 2009年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OXFORD UNIV PRESS INC

During inflammation, lower molecular weight fragments of hyaluronan accumulate, and this is known to be inflammatory and immune-stimulatory. In diseases such as inflammatory bowel disease, inflammatory cells bind to hyaluronan; however, the cellular response and molecular mechanism of hyaluronan-hyaluronan receptor interactions in mononuclear cells are not well understood. The expression of hyaluronan receptors in peripheral blood mononuclear cells (PBMC) was examined. PBMC were stimulated with lower and higher molecular weight hyaluronan (molecular weight 100-150 kDa and 2700 kDa) and the induction of proinflammatory cytokines (interleukin-6 (IL-6) and monocyte chemoattractant protein (MCP-1)) was compared by enzyme-linked immunoabsorbant assay (ELISA). Cells were coincubated with various signaling pathway inhibitors. In addition, neutralizing antibodies against CD44 and TLR4 were added and the effects on PBMC were investigated. Finally, mononuclear cells from CD44-null and toll-like receptor 4 (TLR4) mutant mice were both stimulated with lower molecular weight hyaluronan. Among the hyaluronan receptors, TLR4 and CD44 were markedly expressed on PBMC. Hyaluronan-stimulated PBMC enhanced the attachment to the extracellular matrix. Lower molecular weight hyaluronan induced IL-6 and MCP-1 production in PBMC, but high-molecular-weight hyaluronan did not induce IL-6 and MCP-1 production. An anti-CD44 antibody attenuated the induction of both IL-6 and MCP-1 in lower molecular weight hyaluronan-stimulated PBMC. In both TLR4 mutant and CD44-null mice, the induction of IL-6 by lower molecular weight hyaluronan stimulation was decreased. SB203580 completely abolished IL-6 production in both TLR4 mutant and CD44-null mononuclear cells, while PD98059 abolished IL-6 production in CD44-null mononuclear cells. Hyaluronan receptors, CD44 and TLR4, play distinct roles in cytokine induction in hyaluronan-stimulated mononuclear cells.

DOI： 10.1093/glycob/cwn109

Human eosinophil cationic protein enhances stress fiber formation in Balb/c 3T3 fibroblasts and differentiation of rat neonatal cardiomyocytes 国際誌

Takayuki Fukuda, Miki Iwata, Midori Kitazoe, Takashi Maeda, David Salomon, Satoshi Hirohata, Katsuyuki Tanizawa, Shun'ichi Kuroda, Masaharu Seno

GROWTH FACTORS 27 ( 4 ) 228 - 236 2009年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：TAYLOR & FRANCIS LTD

We found that eosinophil cationic protein (ECP) stimulated the growth of mouse Balb/c 3T3 fibroblasts. ECP-treated 3T3 cells were more flattened and exhibited enhanced stress fiber formation. The enhancement of cytoskeleton after addition of recombinant ECP appeared stable and was able to inhibit disassembly of actin filaments that was induced by fibroblast growth factor-2. The ROCK inhibitor, Y-27632, abrogated this enhancement on stress fiber formation that was induced by ECP indicating the involvement of Rho/ROCK signaling pathway. The effect of ECP was assessed on the differentiation of primary cardiomyocytes derived from rat neonatal heart since the development of actin filaments is significantly related with organization of stress fibers. As the result, both beating rate and the expression of cardiac muscle specific markers such as atrial natriuretic factor were enhanced in the presence of ECP. Thus ECP may also function as a cardiomyocyte differentiation factor.

DOI： 10.1080/08977190902987149

Increased Augmentation Index of the Radial Pressure Waveform in Patients with Paroxysmal Atrial Fibrillation 国際誌

Masayuki Doi, Toru Miyoshi, Satoshi Hirohata, Akihiro Iwabu, Youkou Tominaga, Youko Kaji, Shigeshi Kamikawa, Kosuke Sakane, Tomoki Kitawaki, Kengo F. Kusano, Shozo Kusachi

CARDIOLOGY 113 ( 2 ) 138 - 145 2009年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：KARGER

Objective: The augmentation index, a marker of wave reflection, has been reported to reflect vascular properties and to determine left ventricular (LV) characteristics. We investigated the relationship between the augmentation index and paroxysmal atrial fibrillation (AF). Methods: A total of 244 outpatients (122 patients with paroxysmal AF and 122 age-, and gender-matched controls without paroxysmal AF) were examined during sinus rhythm. The augmentation index was calculated from the radial arterial waveform using applanation tonometry methods. Results: After adjusting for age, gender, heart rate, and medications, the augmentation index was significantly higher in patients with paroxysmal AF than in subjects without paroxysmal AF (means +/- SE: 88.9 +/- 1.0 and 81.8 +/- 1.0%, respectively; p < 0.001). In all subjects, an increase in the augmentation index was significantly correlated with LV hypertrophy and left atrial enlarge ment. Multiple logistic analysis revealed that an increase in the augmentation index was significantly related with paroxysmal AF, and the adjusted odds ratio of paroxysmal AF was approximately 1.8 for each 10% augmentation index increase (p < 0.01). Conclusion: An increase in the augmentation index was independently associated with paroxysmal AF. This result suggests that enhanced wave reflection may be related to the development of AF. Copyright (C) 2008 S. Karger AG, Basel

DOI： 10.1159/000177951

Serum N-3 Polyunsaturated Fatty Acid Levels Correlate With the Extent of Coronary Plaques and Calcifications in Patients With Acute Myocardial Infarction

Masayuki Ueeda, Takenori Doumei, Yoichi Takaya, Ryoko Shinohata, Yusuke Katayama, Nobuhiko Ohnishi, Atsushi Takaishi, Toru Miyoshi, Satoshi Hirohata, Shozo Kusachi

CIRCULATION JOURNAL 72 ( 11 ) 1836 - 1843 2008年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JAPANESE CIRCULATION SOC

Background The relationship between serum fatty acid levels and the extent of coronary plaques and calcification was examined in patients with acute myocardial infarction (AMI).
Methods and Results The serum levels of the n-3 polyunsaturated fatty acids (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) and the n-6 polyunsaturated fatty acids (arachidonic acid (AA) and dihomo-(gamma-linolenic acid (DGLA)) were determined using gas chromatography on admission of 95 consecutive patients with their first AMI and 17 controls. Using multidetector-row computed tomography, soft plaques and calcification lesions were scored according to the extent of coronary involvement. Serum logarithmic transformed (log) EPA and logDHA levels were inversely correlated with soft plaque scores (r=-0.546, p < 0.0001 and r= -0.377, p < 0.0001, respectively). Serum logAA and logDGLA levels were not significantly correlated with soft plaque scores. Serum logEPA and logDHA levels were significantly, but weakly, correlated with calcification scores. Multivariate analysis with clinical characteristics and risk factors selected serum n-3 polyunsaturated fatty acid levels as independent factors associated with the extent of coronary soft plaques.
Conclusion The present study demonstrates a significant correlation between serum n-3 polyunsaturated fatty acid levels and the extent of coronary soft plaques and calcification in AMI patients. (Circ J 2008; 72: 1836-1843)

DOI： 10.1253/circj.CJ-08-0249

Serum Adipocyte Fatty Acid-Binding Protein Levels are Independently Associated with Coronary Atherosclerosis

Toru Miyoshi, Atsushi Hirohata, Shinichi Usui, Keizo Yamamoto, Kazuyoshi Hina, Satoshi Hirohata, Shozo Kusachi, Yoshifumi Ninomiya, Kengo F. Kusano

CIRCULATION 118 ( 18 ) S470 - S470 2008年10月

The Impact of Increased Augmentation Index of Radial Pressure Waveform on Paroxysmal Atrial Fibrillation

Youko Kaji, Toru Miyoshi, Masayuki Doi, Satoshi Hirohata, Tadahisa Uesugi, Shigeshi Kamikawa, Kosuke Sakane, Shozo Kusachi, Kengo F. Kusano

CIRCULATION 118 ( 18 ) S730 - S730 2008年10月

Prone position is essential for detection of pulmonary vein pseudostenosis by enhanced multidetector computed tomography in patients who undergo pulmonary vein isolation

Hirosuke Yamaji, Kazuyoshi Hina, Hiroshi Kawamura, Takashi Murakami, Masaaki Murakami, Keizo Yamamoto, Atsushi Hirohata, Toru Miyoshi, Satoshi Hirohata, Shozo Kusachi

CIRCULATION JOURNAL 72 ( 9 ) 1460 - 1464 2008年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JAPANESE CIRCULATION SOC

Background pulmonary vein (PV) stenosis is a major complication of PV isolation (PVI) by catheter ablation, so in the present study the optimal position for detecting PV stenosis on enhanced multidetector computed tomography (MDCT) image acquisition was determined.
Methods and Results The 64-slice enhanced MDCT was carried out before and after PVI in 116 consecutive patients with atrial fibrillation while they were in the prone position, as well as while supine. The supine position MDCT image showed > 50% diameter stenosis of the PV in 11 (9%) patients before PVI (% diameter stenosis: mean 55 +/- 4%, range 51-65%). Greater than > 50% diameter stenosis was seen in the left inferior PV in all 11 patients. The prone position attenuated the PV stenosis findings in the MDCT images in all 11 patients (mean 9 +/- 6%, range 2-18%). Stenosis visualized on images acquired in the supine position was, therefore, concluded to be pseudostenosis caused by descending aorta compression. At 3 months after PVI, no significant changes in PV diameter were observed in these 11 patients.
Conclusion The present study demonstrated that the prone position is essential for eliminating PV pseudostenosis observed oil supine-position enhanced MDCT images. The results also indicate that preexisting PV organic stenosis is rare.

DOI： 10.1253/circj.CJ-08-0055

Association of corrected QT dispersion with symptoms improvement in patients receiving cardiac resynchronization therapy

Kazuyoshi Hina, Hiroshi Kawamura, Takashi Murakami, Keizo Yamamoto, Hirosuke Yamaji, Masaaki Murakami, Satoshi Hirohata, Hiroko Ogawa, Kohsuke Sakane, Shozo Kusachi

HEART AND VESSELS 23 ( 5 ) 325 - 333 2008年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER

Cardiac resynchronization therapy (CRT) is theoretically expected to affect repolarization as well as depolarization. We studied the effects of CRT on corrected QT (QTc) dispersion in association with symptomatic improvement. QTc dispersion was analyzed in 26 consecutive patients (67 +/- 6 years old, 18 men and 8 women) who underwent CRT. CRT responders and nonresponders were defined as patients showing and not showing >= 1 class New York Heart Association symptomatic improvement 3 months after CRT, respectively. QTc interval, QRS width, and QTc dispersion were measured automatically from digital data using an analyzing system. There were 18 CRT responders and 8 nonresponders among the patients. CRT responders showed significantly larger QTc dispersion than CRT nonresponders before CRT (102 +/- 26 vs 40 +/- 12 ms, P < 0.01). A significant decrease in QTc dispersion by CRT was observed in responders (102 +/- 26 to 52 +/- 15 ms, P < 0.01). In contrast, QTc dispersion was not decreased by CRT in nonresponders (40 +/- 12 to 39 +/- 11 ms, not significant). The difference observed before CRT was thus abolished after CRT (52 +/- 15 vs 39 +/- 11 ms, not significant). Baseline values and changes in QRS width or QTc, as well as asynchrony of wall motion determined by tissue Doppler imaging, were not different between CRT responders and nonresponders before CRT. The present study with a small number of patients shows the potential utility of QTc dispersion for distinguishing CRT responders from CRT nonresponders before CRT, and warrants further study with a greater number of patients.

DOI： 10.1007/s00380-008-1056-7

Higher incidence and serum levels of minor cardiac biomarker elevation in sirolimus-eluting stent (Cypher) than bare metal stent implantations 査読国際誌

Tetsushi Seitou, Masaaki Murakami, Issei Komatsubara, Hiroshi Kawamura, Keizo Yamamoto, Kazuyoshi Hina, Satoshi Hirohata, Ryoko Shinohata, Yoshifumi Ninomiya, Shozo Kusachi

CORONARY ARTERY DISEASE 19 ( 2 ) 63 - 69 2008年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS

Objectives Minor cardiac biomarker elevation after percutaneous coronary intervention has long-term prognostic significance. The sirolimus-eluting stent (Cypher) has been reported to require high postinflation pressure for optimal implantation. We examined the incidence of minor cardiac biomarker elevation induced by Cypher implantation.
Methods We measured the serum concentration of cardiac troponin-I (cTnl) 24 h after stenting and those of creatine kinase isoenzyme MB and creatine kinase before, immediately after, and 6, 12 and 24 h after implantation in patients who underwent Cypher stent (CS group; n = 53) or bare metal stent (BMS group; n = 57) implantation.
Results No significant difference in clinical background was observed between the two groups. When a cutoff cTnl value of 0.50ng/ml was used, the CS group showed a significantly higher incidence of cTnl elevation (35.8%, 19/53) than the BMS group (14.0%, 8/57) (P<0.05). Similarly, the incidence of cTnl >= 0.03 ng/ml tended to be higher in the CS group (88.7%, 47/53) than in the BMS group (73.7%, 42/57: 0.05<P<0.10). Furthermore, the CS group showed significantly higher cTnl levels than the BMS group (1.32 +/- 2.38 vs. 0.34 +/- 0.91 ng/ml. P< 0.001). Essentially, similar results were obtained for serum creatine kinase isoenzyme MB and creatine kinase. Among clinical, lesion and procedural characteristics, postinflation pressure for stenting was significantly higher only in the CS group (18.2 +/- 2.8 atm) than in the BMS group (14.0 +/- 2.7 atm) (P< 0.001).
Conclusions The results demonstrated that CS implantation increases the incidence of minor cardiac biomarker elevation compared with BMS. The difference in postinflation pressure could account for the results.

DOI： 10.1097/MCA.0b013e3282f2f189

Web of Science

PubMed

researchmap

Increased augmentation index of radial pulse wave in patients with paroxysmal atrial fibrillation

Toru Miyoshi, Masayuki Doi, Youko Kaji, Satoshi Hirohata, Shigeshi Kamikawa, Shozo Kusachi, Tohru Ohe

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 51 ( 10 ) A304 - A304 2008年3月

OA軟骨破壊におけるアグリカナーゼの役割

鉄永智紀, 広畑聡, 西田圭一郎

関節外科 27 221 - 227 2008年

Association of new arterial stiffness parameter, the cardio-ankle vascular index, with left ventricular diastolic function

Kosuke Sakane, Toru Miyoshi, Masayuki Doi, Satoshi Hirohata, Youko Kaji, Shigeshi Kamikawa, Hiroko Ogawa, Kunihiko Hatanaka, Tomoki Kitawaki, Shozo Kusachi, Kazuhide Yamamoto

Journal of Atherosclerosis and Thrombosis 15 ( 5 ) 261 - 268 2008年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Japan Atherosclerosis Society

Aim: Pulse wave velocity has been used as an index of aortic stiffness. Recently, the cardio-ankle vascular index (CAVI), which reflects the stiffness of the aorta independently of blood pressure, has been developed. In this study, we analyzed the relationship between CAVI and left ventricular (LV) diastolic dysfunction. Methods: A total of 119 patients were referred for echocardiography to evaluate ventricular function. Patients with reduced systolic function were excluded. Patients were divided on the basis of normal or reduced LV diastolic function determined by echocardiography. CAVI was measured using an automatic waveform analyzer. Results: CAVI was significantly higher in patients with reduced LV diastolic function than those with normal LV diastolic function (9.0 ± 1.1 and 8.5 ± 1. 1, p= 0.009). Multiple linear regression analysis revealed that CAVI was independently associated with the ratio of peak early diastolic velocity to peak atrial diastolic velocity an left atrial diameter. When patients were classified on the basis of CAVI quartiles, multiple logistic regression analysis demonstrated that the highest quartile of CAVI showed an increased odds ratio for the presence of IV diastolic dysfunction. Conclusion: The present study revealed that an increased CAVI was independently associated with LV diastolic dysfunction in patient's with preserved systolic function.

DOI： 10.5551/jat.E576

Scopus

PubMed

researchmap

Increased blood pressure levels relative to subjective feelings of intensity of exercise determined with the borg scale in male patients with hypertension 国際誌

Eriko Mayumi, Aya Nishitani, Yoko Yuki, Takaaki Nakatsu, Shinji Toyonaga, Keiichi Mashima, Hiroko Ogawa, Satoshi Hirohata, Shinichi Usui, Ryoko Shinohata, Kousaku Sakaguchi, Shozo Kusachi

CLINICAL AND EXPERIMENTAL HYPERTENSION 30 ( 3-4 ) 191 - 201 2008年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：TAYLOR & FRANCIS INC

We examined the hemodynamic responses to exercise and symptoms in 37 male patients with untreated essential hypertension, and compared the findings with those in 32 age-matched healthy male volunteers by performing a graded symptom-limited exercise test using a bicycle ergometer. The subjective feeling of intensity of exercise was determined using the Borg scale. In the relationship between Borg scores and blood pressure (BP), patients with hypertension showed higher systolic BP and diastolic BP relative to the Borg scores than the controls. Consequently, patients with hypertension showed significantly higher systolic BP with Borg scores <= 3 (subjective symptoms <= moderately hard) than the controls (177.8 +/- 27.0 vs. 143.7 +/- 17.9 mmHg, p 0.0001). Similarly, significantly higher diastolic BP with Borg scores 3 was observed in patients with hypertension than in the controls (101.6 +/- 12.0 vs. 82.6 +/- 11.6 mmHg, p < 0.0001). The pulse pressure with Borg scores 3 was also significantly higher in patients with hypertension than in the controls (76.2 +/- 20.6 vs. 61.0 +/- 13.6 mmHg, p < 0.0001). Hypertensive patients showed a decrease in the high-frequency power of heart rate variability at initial low-load exercise. In conclusion, the present study revealed that there was a greater BP response relative to the Borg score in patients with hypertension than in the controls. Autonomic nerve activity may contribute to some extent to these different relations. A determination of the relationship between the subjective feeling of intensity of the exercise and BP levels caused by a given intensity of load is essential before exercise training in patients, at least in males, with hypertension to avoid increasing the risk of cardiovascular events in association with excessive exercise training.

DOI： 10.1080/10641960802068436

<廣畑 聡>

論文 - 廣畑 聡

<廣畑　聡>

論文 - 廣畑　聡