研究者詳細 - 安藤　瑞生

論文 - 安藤　瑞生

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Prognostic and histogenetic roles of gene alteration and the expression of key potentially actionable targets in salivary duct carcinomas. 査読国際誌

Tomotaka Shimura, Yuichiro Tada, Hideaki Hirai, Daisuke Kawakita, Satoshi Kano, Kiyoaki Tsukahara, Akira Shimizu, Soichiro Takase, Yorihisa Imanishi, Hiroyuki Ozawa, Kenji Okami, Yuichiro Sato, Yukiko Sato, Chihiro Fushimi, Hideaki Takahashi, Takuro Okada, Hiroki Sato, Kuninori Otsuka, Yoshihiro Watanabe, Akihiro Sakai, Koji Ebisumoto, Takafumi Togashi, Yushi Ueki, Hisayuki Ota, Mizuo Ando, Shinji Kohsaka, Toyoyuki Hanazawa, Hideaki Chazono, Yoshiyuki Kadokura, Hitome Kobayashi, Toshitaka Nagao

Oncotarget 9 ( 2 ) 1852 - 1867 2018年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

The molecular characteristics of therapeutically-relevant targets and their clinicopathological implications in salivary duct carcinomas (SDCs) are poorly understood. We investigated the gene alterations and the immunoexpression of crucial oncogenic molecules in 151 SDCs. The mutation rates that were identified, in order of frequency, were as follows: TP53, 68%; PIK3CA, 18%; H-RAS, 16%; BRAF, 4%; and AKT1, 1.5%. PIK3CA/H-RAS/BRAF mutations were more common in de novo SDC than in SDC ex-pleomorphic adenoma. Furthermore, these mutations were mutually exclusive for HER2 overexpression/amplification. TP53 mutations were frequently detected in cases with the aberrant p53 expression, and TP53 missense and truncating mutations were associated with p53-extreme positivity and negativity, respectively. DISH analysis revealed no cases of EGFR amplification. The rates of PI3K, p-Akt, and p-mTOR positivity were 34%, 22%, and 66%, respectively; PTEN loss was observed in 47% of the cases. These expressions were correlated according to the signaling axis. Cases with PI3K negativity and PTEN loss appeared to show a lower expression of androgen receptor. In the multivariate analysis, patients with SDC harboring TP53 truncating mutations showed shorter progression-free survival. Conversely, p-Akt positivity was associated with a favorable outcome. This study might provide information that leads to advances in personized therapy for SDC.

DOI： 10.18632/oncotarget.22927

PubMed

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The prognostic value of TP53 mutations in hypopharyngeal squamous cell carcinoma 査読

Go Omura, Mizuo Ando, Yasuhiro Ebihara, Yuki Saito, Kenya Kobayashi, Osamu Fukuoka, Ken Akashi, Masafumi Yoshida, Takahiro Asakage, Tatsuya Yamasoba

BMC Cancer 17 ( 1 ) 898 2017年12月

Prognostic value of ALDH2 polymorphism for patients with oropharyngeal cancer in a Japanese population 査読

Hirotaka Shinomiya, Hitomi Shinomiya, Mie Kubo, Yuki Saito, Masafumi Yoshida, Mizuo Ando, Masanori Teshima, Naoki Otsuki, Naomi Kiyota, Ryohei Sasaki, Kenichi Nibu

PLOS ONE 12 ( 12 ) e0187992 2017年12月

The impact of elevated C-reactive protein level on the prognosis for oro-hypopharynx cancer patients treated with radiotherapy 査読

Atsuto Katano, Wataru Takahashi, Hideomi Yamashita, Kentaro Yamamoto, Mizuo Ando, Masafumi Yoshida, Yuki Saito, Osamu Abe, Keiichi Nakagawa

SCIENTIFIC REPORTS 7 ( 1 ) 17805 2017年12月

Current status of superficial pharyngeal squamous cell carcinoma in Japan 査読

Ryoko Rikitake, Mizuo Ando, Yuki Saito, Seiichi Yoshimoto, Tatsuya Yamasoba, Takahiro Higashi

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY 22 ( 5 ) 826 - 833 2017年10月

Prognostic value of lymphovascular invasion of the primary tumor in hypopharyngeal carcinoma after total laryngopharyngectomy 査読

Yuki Saito, Go Omura, Kazuo Yasuhara, Ryoko Rikitake, Ken Akashi, Osamu Fukuoka, Masafumi Yoshida, Mizuo Ando, Takahiro Asakage, Tatsuya Yamasoba

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 39 ( 8 ) 1535 - 1543 2017年8月

Prolonged denervation induces remodeling of nasal mucosa in rat model of posterior nasal neurectomy 査読

Hironobu Nishijima, Kenji Kondo, Makiko Toma-Hirano, Shu Kikuta, Mizuo Ando, Rumi Ueha, Tatsuya Yamasoba

INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY 7 ( 7 ) 670 - 678 2017年7月

Survival impact of local extension sites in surgically treated patients with temporal bone squamous cell carcinoma 査読

Go Omura, Mizuo Ando, Yuki Saito, Osamu Fukuoka, Ken Akashi, Masafumi Yoshida, Akinobu Kakigi, Takahiro Asakage, Tatsuya Yamasoba

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY 22 ( 3 ) 431 - 437 2017年6月

Association between ear-picking habits and carcinoma of external auditory canal 査読

Ryohei Ishiura, Takuya Iida, Akinobu Kakigi, Mizuo Ando, Masafumi Yoshida, Yuki Saito, Tatsuya Yamasoba, Isao Koshima

Japanese Journal of Head and Neck Cancer 43 ( 1 ) 76 - 78 2017年

Association of the upregulated expression of focal adhesion kinase with poor prognosis and tumor dissemination in hypopharyngeal cancer 査読

Go Omura, Mizuo Ando, Yuki Saito, Kenya Kobayashi, Masafumi Yoshida, Yasuhiro Ebihara, Kaori Kanaya, Chisato Fujimoto, Takashi Sakamoto, Kenji Kondo, Takahiro Asakage, Tatsuya Yamasoba

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 38 ( 8 ) 1164 - 1169 2016年8月

Induction Chemotherapy for p16 Positive Oropharyngeal Squamous Cell Carcinoma. 査読国際誌

Saito Y, Ando M, Omura G, Yasuhara K, Yoshida M, Takahashi W, Yamasoba T

Laryngoscope investigative otolaryngology 1 ( 2 ) 28 - 32 2016年4月

Mutational Landscape and Antiproliferative Functions of ELF Transcription Factors in Human Cancer 査読

Mizuo Ando, Masahito Kawazu, Toshihide Ueno, Daizo Koinuma, Koji Ando, Junji Koya, Keisuke Kataoka, Takahiko Yasuda, Hiroyuki Yamaguchi, Kazutaka Fukumura, Azusa Yamato, Manabu Soda, Eirin Sai, Yoshihiro Yamashita, Takahiro Asakage, Yasushi Miyazaki, Mineo Kurokawa, Kohei Miyazono, Stephen D. Nimer, Tatsuya Yamasoba, Hiroyuki Mano

CANCER RESEARCH 76 ( 7 ) 1814 - 1824 2016年4月

Comorbidity as predictor poor prognosis for patients with advanced head and neck cancer treated with major surgery 査読

Go Omura, Mizuo Ando, Yuki Saito, Kenya Kobayashi, Tatsuya Yamasoba, Takahiro Asakage

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 38 ( 3 ) 364 - 369 2016年3月

Clinical Value of the Epstein-Barr Virus and p16 Status in Patients with Nasopharyngeal Carcinoma: A Single-Centre Study in Japan 査読

Yuki Saito, Tetsuo Ushiku, Go Omura, Kazuo Yasuhara, Masafumi Yoshida, Wataru Takahashi, Mizuo Ando, Masashi Fukayama, Tatsuya Yamasoba

ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY HEAD AND NECK SURGERY 78 ( 6 ) 334 - 343 2016年

Human Papillomavirus 16 Physical Status and the TP53 Codon 72 Polymorphism in Japanese HPV-Positive Oropharyngeal Cancer Patients 査読

Yuki Saito, Mizuo Ando, Chisato Fujimoto, Go Omura, Kenya Kobayashi, Takahiro Asakage, Tatsuya Yannasoba

ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY HEAD AND NECK SURGERY 78 ( 1 ) 46 - 54 2016年

Maxillary carcinosarcoma: Identification of a novel MET mutation in both carcinomatous and sarcomatous components through next generation sequencing 査読

Mizuo Ando, Yuki Saito, Teppei Morikawa, Go Omura, Kenya Kobayashi, Ken Akashi, Masafumi Yoshida, Yasuhiro Ebihara, Chisato Fujimoto, Masashi Fukayama, Tatsuya Yamasoba, Takahiro Asakage

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 37 ( 12 ) E179 - E185 2015年12月

Retrospective study of laryngeal preservation treatment for hypopharyngeal carcinoma with transoral resection or induction chemotherapy 査読

Takahiro Asakage, Mizuo Ando, Masafumi Yoshida, Yuki Saito, Go Omura, Tatsuya Yamasoba

Journal of Otolaryngology of Japan 118 ( 9 ) 1118 - 1123 2015年9月

Prognostic value of p16 expression irrespective of human papillomavirus status in patients with oropharyngeal carcinoma 査読

Yuki Saito, Masafumi Yoshida, Go Omura, Kenya Kobayashi, Chisato Fujimoto, Mizuo Ando, Takashi Sakamoto, Takahiro Asakage, Tatsuya Yamasoba

JAPANESE JOURNAL OF CLINICAL ONCOLOGY 45 ( 9 ) 828 - 836 2015年9月

Nerve Growth Factor Signals as Possible Pathogenic Biomarkers for Perineural Invasion in Adenoid Cystic Carcinoma 査読

Kenya Kobayashi, Mizuo Ando, Yuki Saito, Kenji Kondo, Go Omura, Aya Shinozaki-Ushiku, Masashi Fukayama, Takahiro Asakage, Tatsuya Yamasoba

OTOLARYNGOLOGY-HEAD AND NECK SURGERY 153 ( 2 ) 218 - 224 2015年8月

Disease control and clinicopathological prognostic factors of total pharyngolaryngectomy for hypopharyngeal cancer: a single-center study 査読

Go Omura, Mizuo Ando, Yuki Saito, Kenya Kobayashi, Tatsuya Yamasoba, Takahiro Asakage

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY 20 ( 2 ) 290 - 297 2015年4月

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