研究者詳細 - 安藤　瑞生

論文 - 安藤　瑞生

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Association between swimming lessons and rhinitis in school children: A nationwide birth cohort study. 査読国際誌

Kensuke Uraguchi, Toshiharu Mitsuhashi, Naomi Matsumoto, Soshi Takao, Seiichiro Makihara, Mizuo Ando, Takashi Yorifuji

International journal of pediatric otorhinolaryngology 195 112415 - 112415 2025年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVE: Swimming is one of the most popular extracurricular activities for school-aged children in Japan, but its potential impact on the development of rhinitis has been debated. This study aimed to investigate the relationship between swimming lessons and rhinitis onset in school-aged children. METHODS: We used the data from the "Longitudinal Survey of Babies in the 21st Century," a nationwide prospective birth cohort of 43,767 children born in Japan between May 10 and 24, 2010. We included follow-up surveys until the children were 9 years old, focusing on swimming lesson participation and rhinitis onset. Children were grouped based on swimming lesson frequency, and rhinitis was identified through parental reports. Poisson regression and generalized estimating equation (GEE) model were used for statistical analysis. RESULTS: Swimming lessons and rhinitis showed a notable association in 18,150 children evaluated. The occasional and consistent swimming groups had increased rhinitis (adjusted risk ratio [aRR] = 1.11; 95 % confidence interval (CI), 1.02-1.22; aRR = 1.16; 95 % CI, 1.09-1.23), respectively. The GEE models were consistent with these findings, demonstrating the population average effects across repeated measures data (aRR = 1.13; 95 % CI, 1.08-1.18). CONCLUSION: This study found that swimming lessons may increase the risk of rhinitis in children, highlighting the need to reevaluate their implications for child health.

DOI： 10.1016/j.ijporl.2025.112415

Near-infrared photoimmunotherapy for recurrent cancer at the base of the tongue. 査読国際誌

Takuma Makino, Asami Nishikori, Yasuharu Sato, Yuto Naoi, Junya Matsumoto, Shohei Fujimoto, Mizuo Ando

Photodiagnosis and photodynamic therapy 104719 - 104719 2025年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

Near-infrared photoimmunotherapy (NIR-PIT) is a novel therapeutic approach that targets epidermal growth factor receptor (EGFR). In NIR-PIT, administration of cetuximab sarotalocan sodium is followed by laser irradiation of the affected area, which theoretically should induce tumor cell death. However, residual tumors are occasionally observed. This study investigated factors that influence the therapeutic efficacy of NIR-PIT in cases of recurrence of cancer at the base of the tongue. Six patients undergoing 11 treatment cycles were analyzed, focusing on the puncture interval of cylindrical diffusers and the expression of EGFR in tumors. The results demonstrated that a puncture interval of ≤12 mm significantly enhanced therapeutic efficacy, with one case achieving complete response. EGFR expression was positive in all cases and expression score showed no significant change between before and after treatment. These findings suggest that puncture interval plays a critical role in therapeutic outcomes, whereas EGFR expression may not directly influence treatment efficacy.

DOI： 10.1016/j.pdpdt.2025.104719

Impact of smoking on age-related deterioration in hearing: A cohort study using health checkups. 査読国際誌

Kensuke Uraguchi, Akiko Sugaya, Etsuji Suzuki, Naomi Matsumoto, Eriko Yanagi, Soshi Takao, Takashi Yorifuji, Mizuo Ando

Archives of gerontology and geriatrics 137 105947 - 105947 2025年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVE: This study aimed to investigate the association between smoking status and hearing loss, both at baseline and annually, using longitudinal health checkup data. METHODS: We analyzed data from 2349 participants (9250 health checkups) aged 20 years and older who underwent comprehensive health checkups at Takinomiya General Hospital in Kagawa, Japan, between 2015 and 2023. Hearing thresholds at 1.0 kHz and 4.0 kHz were measured using pure-tone audiometry, where higher thresholds indicate worse hearing. Smoking status was categorized as never-smoker, past smoker, or current smoker (<10 or ≥10 cigarettes/day). Multilevel linear regression models adjusted for age, sex, occupation, and medical history were used to assess baseline differences and annual changes in hearing thresholds. RESULTS: At 1.0 kHz, smoking was not significantly associated with hearing thresholds. However, at 4.0 kHz, current smokers (≥10 cigarettes/day) had worse baseline hearing, with an adjusted threshold increase of 2.51 dB compared with never-smokers (p < 0.01). Additionally, past smokers and current smokers (≥10 cigarettes/day) experienced significantly faster deterioration in hearing annually at 4.0 kHz, with reductions of 0.73 dB/year (p < 0.01) and 0.78 dB/year (p < 0.01), respectively. DISCUSSION: These findings suggest that smoking is associated with high-frequency hearing impairment and may contribute to accelerated age-related hearing loss. The effect of smoking cessation was not evident in past smokers, and further studies are warranted to examine this hypothesis.

DOI： 10.1016/j.archger.2025.105947

Close Spatial Interactions between Cancer Cells and Cancer-Associated Fibroblasts Suppress Antitumor Immunity. 査読国際誌

Yuto Naoi, Yumi Inukai, Tomoka Izumikawa, Joji Nagasaki, Takamasa Ishino, Youki Ueda, Yin Min Thu, Miho Fujiwara, Takahiro Baba, Go Makimoto, Ken Suzawa, Kazuhiro Okada, Ken-Ichi Yamamoto, Masakiyo Sakaguchi, Shuta Tomida, Yoshinobu Maeda, Shinichi Toyooka, Mizuo Ando, Yosuke Togashi

Cancer immunology research 2025年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

Cancer-associated fibroblasts (CAFs) play immunosuppressive roles in the tumor microenvironment (TME). Specifically, they reportedly act as physical barriers preventing immune cell infiltration. However, the spatial relationships between CAFs and cancer cells in antitumor immunity remain unknown. In this study, we established three-dimensional (3D) constructs, in which the spatial relationships were controlled using a 3D bioprinter. Using these models, we found that the mixed distribution of fibroblasts (FBs) and cancer cells suppressed the antitumor immunity more than the surrounding distribution of FBs as physical barriers. The 3D construct with mixed distribution promoted transforming growth factor (TGF)-β and periostin (encoded by Postn gene) crosstalk, resulting in immunosuppression. Postn-knockdown in FBs decreased the TGF-β production in the mixed 3D construct and activated antitumor immunity both in vitro and in vivo. Clinically, patients with head and neck cancer or lung cancer showing mixed distribution of α-smooth muscle actin+ myofibroblast-like CAFs exhibited worse prognosis after programmed death protein-1 blockade therapies, and lower CD8+ T cell infiltration than those that had CAFs surrounding cancer cells. Overall, our findings suggest that the close interactions of CAFs and cancer cells facilitate immunosuppression, rather than the physical barriers created by CAFs, highlighting their potential as biomarkers and therapeutic targets for cancer immunotherapies based on spatial relationships. Furthermore, this study highlights the beneficial applications of 3D bioprinters.

DOI： 10.1158/2326-6066.CIR-24-1144

Newly formed adrenergic nerve fibers and perineural invasion in head and neck squamous cell carcinoma: a multicohort study. 査読国際誌

Toshihiko Sakai, Yuki Saito, Koji Yamamura, Osamu Fukuoka, Masafumi Yoshida, Mizuo Ando, Yasuhiro Ebihara, Hironobu Nishijima, Kenji Kondo, Tatsuya Yamasoba

Japanese journal of clinical oncology 2025年6月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVE: This study investigated the role of newly formed adrenergic nerve fibers in the tumor microenvironment in promoting tumor growth, focusing on the relationship between perineural invasion and adrenergic axonogenesis in oral cavity cancer. METHODS: We analyzed 70 and 14 patients with oral tongue squamous cell carcinoma and oral cavity squamous cell carcinoma, respectively, from our institution and 465 patients with head and neck cancer from The Cancer Genome Atlas (TCGA). In the oral tongue squamous cell carcinoma cohort, the extent of tyrosine hydroxylase (TH) and growth-associated protein 43 (GAP43) immunostaining in peritumoral nerves were evaluated and compared with perineural invasion. In the oral cavity squamous cell carcinoma and TCGA cohorts, TH and GAP43 expressions were compared with perineural invasion. Survival was analyzed based on gene expression levels in TCGA cohort. RESULTS: In the oral tongue squamous cell carcinoma cohort, TH positivity was associated with perineural invasion (P = .01). A positive correlation was observed between wild-type p53 immunostaining and TH negativity (P = .03). Double immunostaining for TH and GAP43 showed a 76% concordance rate. In the oral cavity squamous cell carcinoma cohort, a positive association between GAP43 expression and perineural invasion was suggested. TCGA cohort showed a positive association between TH expression and perineural invasion (P < .001). High GAP43 expression was associated with poor prognosis (P = .04). CONCLUSIONS: TH expression may play a role in adrenergic axonogenesis in the tumor microenvironment and may participate in the pathogenesis of perineural invasion in oral cavity squamous cell carcinoma.

DOI： 10.1093/jjco/hyaf098

Assessment of Listening Effort by Eye Blinks and Head Tilt Angle Using a Glasses-Type Wearable Device. 査読国際誌

Masahito Minagi, Kei Tabaru, Hamish Innes-Brown, Manae Kubo, Taiki Komoda, Yuko Kataoka, Mizuo Ando

Ear and hearing 2025年6月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: Listening effort is the mental effort that increases in situations where listening is challenging. Objective indicators are needed to assess listening effort, but no established testing methods can be performed in a daily environment. We used a glasses-type wearable device (JINS MEME, JINS Inc., Tokyo, Japan) equipped with an electrooculography sensor and an acceleration/angular velocity sensor to measure the number of eye blinks and changes in head tilt angle during listening under noise and investigated its use as an objective indicator of listening effort. DESIGN: The study included 16 normal-hearing individuals (mean = 27.94 years, SD = 7.18 years). They wore a glasses-type wearable device and were asked to repeat a passage presented at a sound pressure level of 60 dB sound pressure level. Three conditions were performed with signal to noise ratios (SNRs) of 0, -5, and -10 dB SNR. The number of eye blinks and head tilt angle were measured during the time spent listening to the conversation (listening period) and the time spent repeating it after listening (response period). After each task, the effort and motivation required for that trial were evaluated subjectively on a scale. Friedman tests were performed on the percentage of correct words repeated as well as subjective scores for effort and motivation based on the SNR. A linear mixed model was used to evaluate the effects of SNR and interval (listening period and response period) on the number of eye blinks and head tilt angle. In addition, correlation analysis was performed on each indicator. RESULTS: As the SNR decreased, the correct answer rate and motivation score decreased, and the effort score increased. These changes were significantly greater at -10 dB SNR than in the other 2 conditions. The eye blink rate was significantly higher in the -5 dB SNR condition than at 0 dB SNR, and was significantly higher in the response period than in the listening period, regardless of SNR. The head tilt angle was tilted forward when the SNR decreased in the listening period and response period sections. No significant correlation was observed between the indicators. CONCLUSIONS: The number of eye blinks increased during listening in noise, but decreased with decreased subjective motivation. The head tilt angle tilted forward when the noise load increased, indicating that the participant tilted more toward the sound source. The changes in the number of eye blinks and head tilt angle during listening in noise may be objective indicators related to listening effort that can be detected quantitatively and simply using a glasses-type wearable device.

DOI： 10.1097/AUD.0000000000001688

Application of intratympanic steroid injection as salvage therapy for idiopathic sudden sensorineural hearing loss. 査読国際誌

Yasutoshi Komatsubara, Tomoyasu Tachibana, Yuko Kataoka, Akifumi Kariya, Chieko Furukawa, Asuka Sato, Yuto Naoi, Mizuo Ando

Auris, nasus, larynx 52 ( 3 ) 248 - 252 2025年6月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: Although several studies have reported the benefits of intratympanic steroid injection (ISI) in the treatment of idiopathic sudden sensorineural hearing loss (SSHL), its effectiveness remains controversial. The purpose of this study was to evaluate the efficacy of ISI as a salvage therapy for SSHL and identify factors associated with treatment outcomes. METHODS: We retrospectively reviewed the medical records of 119 patients who received systemic steroids for the treatment of SSHL at our hospital between 2014 and 2023. Of the 76 patients who were not complete recovery after systemic administration, 56 were treated using ISI as a salvage therapy. RESULTS: Among the 76 patients who were not complete recovery after systemic administration, a short period between onset and systemic steroid administration (<4 days) showed favorable treatment effects (p = 0.020). We focused on the 56 patients treated using salvage ISI therapy to evaluate the prognostic factors affecting the efficacy of ISI therapy. The mean hearing loss values were 84.1 dB at the initial visit, 70.7 dB on completion of systemic steroid administration, and 61.8 dB at the final evaluation after ISI. In the univariate analysis, patients who received ISI <23 days after SSHL onset, those who had a hearing loss of ≥60 dB at the initial visit, and those who presented with vertigo at the initial presentation had better hearing recovery with ISI than those who did not (p < 0.01, p = 0.021, and p = 0.052, respectively). Multivariate analysis revealed that a period of <23 days from onset to salvage therapy was independently associated with favorable ISI effects (p = 0.032). CONCLUSIONS: In patients with SSHL, the introduction of salvage ISI therapy <23 days after onset contributes to good hearing recovery. In addition, salvage ISI therapy might be an optional treatment for patients whose hearing loss is ≥60 dB at the initial visit or who present with vertigo at the initial examination.

DOI： 10.1016/j.anl.2025.03.006

Endoscopic surgical strategy for highly vascular pediatric sinonasal and pterygopalatine fossa tumors. 査読国際誌

Aiko Shimizu, Seiichiro Makihara, Minori Noda, Aya Murai, Mizuo Ando

Auris, nasus, larynx 52 ( 3 ) 243 - 247 2025年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

Pediatric sinonasal tumors are rare, and minimally invasive approaches are preferred because of unknown long-term effects on development. We report three cases of highly vascular pediatric sinonasal and pterygopalatine fossa tumors that were successfully removed using an endonasal endoscopic approach with transcatheter arterial embolization (TAE). The patients (9-11 years old) had contrast-enhanced tumors in the left ethmoid sinus near the sphenopalatine foramen in case 1, in the right nasal cavity near the sphenopalatine foramen in case 2, and in the right pterygopalatine fossa in case 3, with diameters of 32, 50, and 61 mm, respectively. Computed tomography and magnetic resonance imaging demonstrated tumors with strong contrast enhancement and flow voids in all cases. TAE was performed in all cases on the day of surgery, followed by endoscopic sinus surgery with nasal septal modification. Pathology revealed pyogenic granuloma, nasal polyps, and juvenile angiofibroma. After TAE, tumor reduction improved visualization in case 1. Nasal septum manipulation enabled medial traction and tumor base identification in cases 2 and 3. The combination of preoperative TAE and septal modification proved effective for achieving complete endoscopic tumor removal. No complications occurred, and follow-up at 1-1.5 years showed no tumor recurrence or developmental abnormalities.

DOI： 10.1016/j.anl.2025.04.006

Differential diagnosis between pleomorphic adenoma and carcinoma ex pleomorphic adenoma: focus on clinical and MR findings. 査読国際誌

Asuka Sato, Tomoyasu Tachibana, Yuichiro Kanie, Minami Kakiuchi, Akifumi Kariya, Chieko Furukawa, Yuto Naoi, Yasuharu Sato, Mizuo Ando

Acta oto-laryngologica 1 - 5 2025年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: In parotid tumors, preoperative differential diagnosis between pleomorphic adenoma (PA) and carcinoma ex pleomorphic adenoma (CXPA) remains challenging. OBJECTIVES: The present study aimed to evaluate the clinical characteristics of CXPA and PA and to identify factors associated with the differential diagnosis of these conditions. MATERIAL AND METHODS: We reviewed the medical records of 6 CXPA and 127 PA patients treated surgically at our institution between 2008 and 2024. RESULT: Univariate analysis revealed significant differences in spontaneous pain (p = .044), facial nerve palsy (p = .045), and subjective enlargement (p < .01) between the CXPA and PA patients. Magnetic resonance imaging (MRI) revealed that the proportions of masses with ill-defined margins, localization in the deep lobe, and low apparent diffusion coefficient (ADC) were significantly higher in patients with CXPA than in those with PA (p < .01, p = .048, and p < .01, respectively). Multivariate analysis identified that spontaneous pain and masses with ill-defined margins were associated with CXPA (p = .047 and p = .013, respectively). CONCLUSION: Spontaneous pain and masses with ill-defined margins could be suggestive of CXPA rather than PA. Low ADC levels indicate the possibility of CXPA.

DOI： 10.1080/00016489.2025.2480687

A glucocorticoid-regulating molecule, Fkbp5, may interact with mitogen-activated protein kinase signaling in the organ of Corti of mice cochleae. 査読国際誌

Asuka Sato, Ryotaro Omichi, Yukihide Maeda, Mizuo Ando

Scientific reports 15 ( 1 ) 7506 - 7506 2025年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

FKBP5 is a 51-Da FK506-binding protein and member of the immunophilin family involved in controlling the signaling of glucocorticoid receptor from the cytosol to nucleus. Fkbp5 has previously been shown to be expressed in murine cochlear tissue, including the organ of Corti (i.e., the sensory epithelium of the cochlea). Fkbp5-/- mice as used in this study show hearing loss in the low-frequency (8-kHz) range and click-evoked auditory brainstem response (ABR) threshold compared to wild-type mice. Both Fkbp5-/- and wild-type mice showed hearing loss at all frequencies and click-ABR thresholds at 24 h and 14 days following acoustic overexposure (AO). Tissues of the organ of Corti were subjected to RNA sequencing and KEGG pathway analysis. In Fkbp5-/- mice before AO, the mitogen-activated protein kinase (MAPK) signaling pathway was dysregulated compared to wild-type mice. In wild-type mice at 12 h following AO, the most significantly modulated KEGG pathway was the TNF signaling pathway and major MAPK molecules p38 and Jun were involved in the TNF signaling pathway. In Fkbp5-/- mice at 12 h following AO, the MAPK signaling pathway was dysregulated compared to wild-type mice following AO. In conclusion, Fkbp5 interacts with MAPK signaling in the organ of Corti in mice cochleae.

DOI： 10.1038/s41598-025-92400-2

Treatment strategy for intermediate-risk papillary thyroid cancer: Focus on postoperative hypothyroidism following lobectomy. 査読国際誌

Akifumi Kariya, Tomoyasu Tachibana, Asuka Sato, Chieko Furukawa, Yuto Naoi, Yorihisa Orita, Mizuo Ando

Auris, nasus, larynx 52 ( 1 ) 66 - 70 2025年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVE: An optimal surgical approach for intermediate-risk papillary thyroid cancer (PTC) has not yet been established. The surgical procedure should be determined based on treatment outcomes and postoperative complications. This study aimed to evaluate appropriate surgical strategies for patients with intermediate-risk PTC by comparing treatment outcomes and postoperative complications following total thyroidectomy and lobectomy. METHODS: This retrospective analysis was conducted on 123 patients with intermediate-risk PTC treated in our department between January 2008 and December 2022. The risk of PTC was classified according to the 2024 Guidelines for the Clinical Treatment of Thyroid Nodules from the Japan Association of Endocrine Surgery. RESULTS: Of the 123 patients, 27 underwent total thyroidectomy, and 96 underwent lobectomy. No significant differences were observed between the two surgical groups in terms of survival or recurrence rates. None of the patients showed bilateral recurrent laryngeal nerve (RLN) palsy postoperatively. Postoperative unilateral RLN palsy occurrence differed significantly between the total thyroidectomy and lobectomy groups, with five cases in each (5.2 and 18.5 %, respectively; p = 0.04). Permanent hypoparathyroidism was observed in two patients (7.4 %) in the total thyroidectomy group. Postoperative hypothyroidism developed in 42 (43.8 %) lobectomy cases, with 32 requiring the administration of levothyroxine therapy. A significant association was observed between preoperative thyroid-stimulating hormone (TSH) levels (≥2.0 μIU/mL) and postoperative hypothyroidism (p < 0.001). CONCLUSION: No significant difference in treatment outcomes was observed between patients with intermediate-risk PTC who underwent total thyroidectomy and those who underwent lobectomy. In cases with preoperative TSH levels ≥2.0 μIU/mL, total thyroidectomy may be a more suitable approach, given the increased likelihood of requiring postoperative levothyroxine administration following lobectomy.

DOI： 10.1016/j.anl.2024.12.005

Short-process incudo-stapedioplasty in congenital ear malformation. 査読国際誌

Ryotaro Omichi, Shin Kariya, Akiko Sugaya, Mizuo Ando

Laryngoscope investigative otolaryngology 10 ( 1 ) e70055 2025年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: Although various stapedotomy and stapedectomy techniques exist, anchoring the piston can be challenging. We present a novel surgical approach for treating congenital stapes malformations with an atypical facial nerve trajectory. METHODS: This is a case of a 7-year-old boy presenting with bilateral conductive hearing loss. Prior attempts at tympanoplasty had proven unsuccessful in improving his hearing. Presurgical imaging studies revealed an unusual anatomical configuration, with the facial nerve positioned inferior to the oval window. This anatomical variation precluded the use of conventional prosthesis-anchoring techniques typically employed in stapedotomies. Thus, we devised an innovative approach, opting to anchor the prosthesis to the short process of the incus. RESULTS: This novel technique circumvented the atypical course of the facial nerve, allowing for successful reconstruction of the ossicular chain. The patient demonstrated an acceptable improvement (30 dB gain) in hearing 1-year post-surgery, with no reported complications. CONCLUSION: This case underscores the critical importance of adapting surgical techniques to address the unique anatomical challenges that may arise in the context of congenital ear malformations. It also highlights the potential of the short process of the incus as a viable alternative anchoring site for stapes prostheses, thereby improving the outcomes of such complex cases. This technique not only restored the patient's hearing but also contributed valuable insights into the management of similar cases, potentially improving the quality of life for individuals with rare and challenging anatomical variations. LEVEL OF EVIDENCE: 5.

DOI： 10.1002/lio2.70055

Association Between Dinner-to-Bed Time and Gastroesophageal Reflux-Related Diseases in Children. 査読国際誌

Kensuke Uraguchi, Naomi Matsumoto, Toshiharu Mitsuhashi, Soshi Takao, Seiichiro Makihara, Mizuo Ando, Takashi Yorifuji

Cureus 17 ( 1 ) e77709 2025年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

INTRODUCTION: Gastroesophageal reflux disease (GERD) is characterized by esophageal mucosal injury due to the reflux of gastroduodenal contents. Typical symptoms include heartburn and acid regurgitation. In addition, gastroesophageal reflux (GER) can influence conditions such as otitis media, rhinitis, and asthma. This study aimed to examine the association between dinner-to-bed time and GER-related diseases, such as otitis media, allergic rhinitis, and asthma. METHODS: This was a longitudinal cohort study using secondary data. Data were collected from a large-scale birth cohort study conducted in Japan including babies born in 2001 and 2010. Dinner-to-bed time was categorized as "longer dinner-to-bed time" (>120 minutes), "shorter dinner-to-bed time" (≤120 minutes or less), and "irregular dinner-to-bed time." Modified Poisson regression with robust variance was used to estimate risk ratios (RRs). RESULTS: A total of 60,392 children were included in this study. Children with shorter dinner-to-bed time had a higher risk of asthma (adjusted RR (aRR) = 1.10; 95% confidence interval (CI), 1.03-1.18) than those with longer dinner-to-bed time. However, no significant association was observed between shorter dinner-to-bed time and otitis media or allergic rhinitis. Furthermore, supplementary analyses revealed that the risk of asthma was significantly higher in children born in 2001 (aRR = 1.13; 95% CI, 1.04-1.22). CONCLUSION: This study showed that dinner-to-bed time within 120 minutes after dinner increases the risk of developing asthma. This underscores the importance of considering lifestyle modifications, as certain pediatric asthma cases may be influenced by behaviors that promote GER.

DOI： 10.7759/cureus.77709

Impact of Coronavirus Disease 2019 Emergency Declarations on Surgeries for Deep Neck Infection Incidence in Japan 査読

Kensuke Uraguchi, Naomi Matsumoto, Shohei Fujimoto, Takashi Yorifuji, Mizuo Ando

Journal of Infection and Chemotherapy 102601 - 102601 2024年12月

Survey of pharyngeal foreign bodies in Japan: An ecological study using the nationwide claims data 査読国際誌

Shintaro Tanaka, Kensuke Uraguchi, Etsuji Suzuki, Naomi Matsumoto, Munechika Tsumura, Shohei Fujimoto, Shotaro Miyamoto, Takashi Yorifuji, Mizuo Ando

International Journal of Pediatric Otorhinolaryngology 184 112055 - 112055 2024年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Elsevier BV

OBJECTIVE: Pharyngeal foreign bodies (PFBs) are a prevalent disease affected by food culture and dietary habits, with fish bones as the leading cause. Most studies were limited to specific regions, and a nationwide survey was not conducted in Japan. In this ecological study, we aimed to conduct a nationwide analysis of outpatient PFB cases in Japan over three years, focusing on seasonal trends, sex- and age-stratified cases, and regional differences. METHODS: We used the National Database of Health Insurance Claims and Specific Health Checkups of Japan open data from April 2019 to March 2022. The case data were analyzed by month, age, sex, and prefecture. Additionally, we calculated the standardized claim ratios (SCRs) for each prefecture and investigated the association between dietary habits, food culture, and SCR of PFBs using a two-level linear regression model. RESULTS: We analyzed a total of 164,337 outpatient PFB cases in Japan, revealing an average incidence rate of 45.6 per 100,000 persons. The seasonal trend revealed a peak in July each year from 2019 to 2021, confirming seasonality in PFB incidents. Children reported a higher incidence rate. Living west of Japan and expenditure on fish and shellfish had a strongly positive association with the SCR of PFBs. CONCLUSION: Our nationwide survey reveals that, even within Japan, there were regional variations influenced by food culture and dietary habits. The data showed that PFB incidence was higher among children, highlighting the need for preventive education. LEVEL OF EVIDENCE: Level 3.

DOI： 10.1016/j.ijporl.2024.112055

Endoscopic Transpterygoid Repair of Sphenoid Sinus Meningocele: A Comprehensive Case Report and Literature Review. 査読国際誌

Aiko Shimizu, Seiichiro Makihara, Ryoji Imoto, Koji Hirashita, Mizuo Ando

Auris, nasus, larynx 51 ( 5 ) 875 - 879 2024年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

We report a challenging and uncommon case involving a 53-year-old Japanese man with cerebrospinal fluid (CSF) leakage caused by a meningocele in the lateral recess of the sphenoid sinus. Our innovative treatment approach involved a combination of transpterygoid and endoscopic modified medial maxillectomy techniques, with special emphasis on the preservation of the sphenopalatine artery. This strategic preservation was pivotal to the successful use of the ipsilateral nasoseptal flap for reconstruction, which played a crucial role in the prevention of postoperative CSF leakage. Otolaryngologists and neurosurgeons collaborated to perform the bath-plugging technique; effective collaboration was instrumental to the success of the procedure. This report highlights significant advancement from conventional frontal craniotomy to a more sophisticated endoscopic technique, shows the importance of meticulous surgical planning and execution, emphasizes careful preservation of critical anatomical structures during complex neurosurgical and otolaryngological procedures, and underscores the evolving landscape of surgical approaches for managing complex medical conditions.

DOI： 10.1016/j.anl.2024.08.003

Shifting paradigms in endoscopic sinus surgery: a comprehensive analysis from Japan's national database. 査読国際誌

Seiichiro Makihara, Kensuke Uraguchi, Shohei Fujimoto, Aiko Shimizu, Shin Kariya, Mitsuhiro Okano, Takashi Yorifuji, Mizuo Ando

Acta oto-laryngologica 1 - 6 2024年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: In 2013, Japan established a standardized classification system for categorizing endoscopic sinus surgery (ESS) into types I-V, yet no evaluation has been conducted thereof. OBJECTIVE: We assessed the ESS trends and status in Japan, focusing on outpatient and inpatient surgeries. MATERIAL AND METHODS: This descriptive retrospective cohort study used Japan's National Database of Health Insurance Claims and Specific Health Checkups between 2014 and 2021. The distribution of ESS types I-V and outpatient and inpatient surgeries was analysed, along with age groups and regional differences, focusing on ESS type III. RESULTS: Overall, 427,813 ESS procedures were performed, with types III and IV being most common. Outpatient ESS type III increased substantially compared to inpatient surgeries. Younger individuals favoured outpatient ESS type III over inpatient surgeries, with substantial regional variations across prefectures. CONCLUSIONS AND SIGNIFICANCE: The adoption of a standardized ESS classification in Japan has facilitated a detailed understanding of surgical trends. The shift toward outpatient surgeries, especially for type III ESS, aligns with global trends toward minimally invasive procedures and reflects changing patient preferences and healthcare delivery practices. Consequently, continuous monitoring and research are crucial for adapting surgical practices to the evolving healthcare needs and patient expectations.

DOI： 10.1080/00016489.2024.2389179

Exploring factors influencing the hearing test and hearing aid adoption among Japanese older adults: Implications of recognizing the hearing loss-dementia relationship. 査読国際誌

Ichiro Fukumasu, Yuko Kataoka, Takahiro Tabuchi, Kentaro Egusa, Mizuo Ando

Auris, nasus, larynx 51 ( 4 ) 822 - 827 2024年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVE: The hearing aid adoption rate among older adults in Japan is lower than that in other developed countries. Herein, a survey was conducted to identify this bottleneck and develop countermeasures. This study aimed to examine whether raising awareness of the relationship between hearing loss and dementia is significant for hearing tests and adopting hearing aids. METHODS: A questionnaire was administered to participants aged 65 or older who visited a general hospital to determine the background factors (1) for a recent history of hearing tests, (2) for the desire to visit an otolaryngologist and have a hearing test, (3) for recognizing the hearing loss-dementia relationship, and (4) for adopting hearing aids. RESULTS: A total of 517 patients (mean age, 78.06; SD 6.97), representing 2.4% of the region's older-adult population, participated in the survey. A history of hearing tests within five years was significantly associated with recognizing the hearing loss-dementia relationship (adjusted OR 2.36, 95% CI 1.49-3.72). The desire to visit an otolaryngologist or have a hearing test was significantly associated with recognizing the hearing loss-dementia relationship (adjusted OR 1.70, 95% CI 1.02-2.85). Moreover, 39.3% were aware of the hearing loss-dementia relationship. The significant associated factors were being female (OR 2.50, 95% CI 1.64-3.81) and having interpersonal hobbies (OR 1.66, 95% CI 1.11-2.49). The significant background factors for adopting hearing aids were older age (OR 6.95, 95% CI 1.90-25.40), self-reported severe hearing impairment (OR 5.49, 95% CI 2.55-11.80), and living alone (OR 2.63, 95% CI 1.18-5.89). Recognizing the hearing loss-dementia relationship was not a significant factor. CONCLUSION: Raising awareness of the hearing loss-dementia relationship was not associated with adopting hearing aids for self-reported hearing impairments. However, it may be associated with otolaryngology visits and hearing tests. Thus, steps like hearing screening for older adults are also essential.

DOI： 10.1016/j.anl.2024.07.001

A Rare Subglottic Pleomorphic Adenoma: Magnetic Resonance Findings. 査読

Chieko Furukawa, Tomoyasu Tachibana, Tetsuji Nobuhisa, Yuichiro Kanie, Yoji Wani, Jun-Ya Matsumoto, Akifumi Kariya, Asuka Sato, Iichiro Ishikawa, Yuto Naoi, Mizuo Ando

Acta medica Okayama 78 ( 4 ) 331 - 335 2024年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

No previous study has published magnetic resonance imaging (MRI) findings for a subglottic pleomorphic adenoma. Here, we describe the case of a 62-year-old man with a subglottic pleomorphic adenoma. Endoscopic findings revealed a smooth-surfaced tumor arising from the subglottic posterior wall. MRI revealed the lesion as an isointense region on T1-weighted images, which was homogeneously enhanced. This lesion showed a heterogeneously hyperintense region on T2-weighted images. Diffusion-weighted imaging (DWI) showed slightly high intensity in the same area, with a normal or only slightly high apparent diffusion coefficient (ADC). Laryngomicrosurgery was performed for transoral excision of the subglottic tumor, resulting in a postsurgical diagnosis of pleomorphic adenoma.

DOI： 10.18926/AMO/67549

Middle-Ear Salivary Gland Choristoma with Congenital, Single-Sided Hearing Loss. 査読

Yuichiro Tominaga, Akiko Sugaya, Shin Kariya, Aiko Shimizu, Yuko Kataoka, Mizuo Ando

Acta medica Okayama 78 ( 4 ) 349 - 355 2024年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

Middle-ear salivary gland choristoma (SGCh) is a rare, benign tumor that causes conductive hearing loss owing to middle-ear morphological abnormalities. Early diagnosis is challenging, and surgical resection is indispensable for a definitive diagnosis. We report the case of a 3-year-old boy diagnosed with middle-ear SGCh during the follow-up period for left-sided hearing loss discovered at newborn hearing screening (NHS). Long-term follow-up after the NHS result, subsequent computed tomography/magnetic resonance imaging, and surgical resection led to its relatively early diagnosis and treatment.

DOI： 10.18926/AMO/67554

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