研究者詳細 - 清水　一好

Malcoto Nakamura, Nobuharu Fujii, Kazuyoshi Shimizu, Hisakazu Nishimori, Ken-ichi Matsuoka, Eisei Kondo, Yoshinobu Maeda, Hiroshi Morimatsu, Mitsune Tanimoto

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 22 ( 3 ) S293 - S293 2016年3月

Urinary Albumin Levels Predict Development of Acute Kidney Injury After Pediatric Cardiac Surgery: A Prospective Observational Study 国際誌

Kentaro Sugimoto, Yuichiro Toda, Tatsuo Iwasaki, Kazuyoshi Shimizu, Tomoyuki Kanazawa, Noriko Muto, Hirokazu Kawase, Hiroshi Morimatsu, Kiyoshi Morita, Yohei Maeshima, Kiyoshi Mori, Shunji Sano

JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA 30 ( 1 ) 64 - 68 2016年2月

記述言語：英語出版者・発行元：W B SAUNDERS CO-ELSEVIER INC

Objective: Mortality and morbidity of acute kidney injury (AKI) after cardiac surgery still remain high. The authors undertook the present study to evaluate the utility of early postoperative urinary albumin (uAlb) as a diagnostic marker for predicting occurrence of AKI and its severity in pediatric patients undergoing cardiac surgery.
Design: A prospective observational study.
Setting: A single-institution university hospital.
Participants: All patients <18 years of age who underwent repair of congenital heart disease with cardiopulmonary bypass between July 2010 and July 2012 were included in the study. Neonates age <1 month were excluded from the study population.
Interventions: The association between uAlb and occurrence of AKI within 3 days after admission to the intensive care unit was investigated. Criteria from pediatric modified Risk Injury Failure Loss and End-stage kidney disease (pRIFLE) were used to determine the occurrence of AKI. The value of uAlb was measured at intensive care unit admission immediately after cardiac surgery in all participants from whom a 5-mL urine sample was obtained.
Measurements and Main Results: Of 376 patients, AKI assessed by pRIFLE was identified in 243 (64.6%): 172 for risk (R; 45.7%), 44 for injury (I; 11.7%), and 27 for failure (F; 7.2%). One hundred thirty-three patients (35.4%) were classified as being without AKI (normal [N]) by pRIFLE. The concentration of uAlb was significantly higher in AKI patients than in non-AKI patients (median [interquartile range]): uAlb (mu g/mL): 13.5 (6.4-39.6) v 6.0 (3.4-16), p < 0.001; uAlb/Cr (mg/gCr): 325 (138-760) v 121 (53-269), p < 0.001.
Conclusions: The utility of uAlb for prompt diagnosis of AKI was shown. Obtaining uAlb measurements early after pediatric cardiac surgery may be useful for predicting the occurrence and severity of AKI. (C) 2016 Elsevier Inc. All rights reserved.

DOI： 10.1053/j.jvca.2015.05.194

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拡張障害型心不全治療に対して横隔膜電位(Edi)モニタリングを活用した一症例

吉鷹志保, 清水一好, 岡原修司, 落葉佑昌, 日笠友起子, 廣井一正, 鈴木聡, 林真雄, 森松博史

日本集中治療医学会雑誌 23 ( Suppl. ) 551 - 551 2016年1月