Updated on 2024/06/15

写真a

 
Takuya KATAOKA
 
Organization
Faculty of Interdisciplinary Science and Engineering in Health Systems Assistant Professor
Position
Assistant Professor
External link

Degree

  • 博士(工学) ( 2021.3   長岡技術科学大学 )

Research Interests

  • 光機能化学

  • 生体材料工学

  • 無機/有機ハイブリッド化学

  • ナノバイオセラミックス

Research Areas

  • Nanotechnology/Materials / Composite materials and interfaces

  • Nanotechnology/Materials / Structural materials and functional materials

  • Life Science / Biomaterials

  • Nanotechnology/Materials / Nanomaterials

Education

  • Nagaoka University of Technology   大学院工学研究科   エネルギー・環境工学専攻

    2018.4 - 2021.3

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  • Nagaoka University of Technology   大学院工学研究科   物質材料工学専攻

    2016.4 - 2018.3

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  • Nagaoka University of Technology   工学部   材料開発工学課程

    2012.4 - 2016.3

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Research History

  • Okayama University   学術研究院ヘルスシステム統合科学学域   Assistant Professor

    2021.4

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  • Japan Society for the Promotion of Science

    2018.4 - 2021.3

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Professional Memberships

Committee Memberships

  • 公益社団法人日本セラミックス協会   第61回セラミックス基礎科学討論会 実行委員会 委員  

    2023.1   

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Papers

  • Synthesis and structural characterization of Sr(II) ion-containing octacalcium phosphate incorporated with both 2,6-pyridinedicarboxylate and succinate ions as a bone defect filler with multiple drug loading capability Reviewed

    Takuya Kataoka, Seita Nishiyama, Eiji Fujii, Tomohiko Yoshioka, Satoshi Hayakawa

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   134001 - 134001   2024.4

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.colsurfa.2024.134001

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  • Incorporation behavior of Mg(II) ion into hydroxyapatite in the presence of chitosan Reviewed

    Takuya Kataoka, Yuhi Yasuhira, Eiji Fujii, Tomohiko Yoshioka, Satoshi Hayakawa

    Journal of the Ceramic Society of Japan   131 ( 9 )   569 - 574   2023.9

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    Authorship:Lead author, Corresponding author   Publishing type:Research paper (scientific journal)   Publisher:Ceramic Society of Japan  

    DOI: 10.2109/jcersj2.23102

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  • Functional evaluation of mineral trioxide aggregate cement with choline dihydrogen phosphate Reviewed

    Kazuhisa TABIRA, Noboru KAJIMOTO, Hirogo MINAMISAWA, Taira SATO, Michito MARUTA, Kyoko OKA, Takuya KATAOKA, Tomohiko YOSHIOKA, Satoshi HAYAKAWA, Kanji TSURU

    Dental Materials Journal   42 ( 4 )   485 - 492   2023.7

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    Publishing type:Research paper (scientific journal)   Publisher:Japanese Society for Dental Materials and Devices  

    DOI: 10.4012/dmj.2022-283

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  • Effective Thermal Diffusion of Eu(III) and F Ions into Hydroxyapatite Nanoparticles by Citric Acid Coordinative Mediation Reviewed

    Wanyu Shi, Zizhen Liu, Iori Yamada, Daichi Noda, Takuya Kataoka, Kenji Shinozaki, Motohiro Tagaya

    ACS Applied Nano Materials   2023.2

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    Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    DOI: 10.1021/acsanm.2c04358

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  • Investigation into the Photochemical Properties of Methylene Blue-Immobilized Hydroxyapatite Nanoparticles for Theranostic Application Reviewed

    Iori Yamada, Takuya Kataoka, Ryota Ikeda, Motohiro Tagaya

    ACS Applied Bio Materials   2023.1

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    Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    DOI: 10.1021/acsabm.2c00756

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  • Adsorption of tris(8-hydroxyquinolinato)aluminum on phosphoric acid-containing mesoporous silica particles Reviewed

    Wanyu Shi, Zizhen Liu, Takuya Kataoka, Yuri Kurakami, Motohiro Tagaya

    Materials Chemistry and Physics   127334 - 127334   2023.1

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    Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.matchemphys.2023.127334

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  • Investigation of the Surface Elution Mechanism of Citric Acid-Coordinated Hydroxyapatite Nanoparticles in Biological Solutions Reviewed

    Takuya Kataoka, Takumi Hashimoto, Wanyu Shi, Motohiro Tagaya

    Industrial & Engineering Chemistry Research   61 ( 30 )   10915 - 10921   2022.7

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    We clarified the surface elution behavior of citric acid (Cit) ions from Cit-coordinated europium(III) ion (Eu3+)-doped hydroxyapatite (CEH) nanoparticles in three different biological solutions (i.e., phosphate buffer (PB), carbonate buffer (CB), and simulated body fluid (SBF)). Specifically, the elution behavior of Cit from the CEH nanoparticles in SBF was clarified as compared with the cases in PB and CB. Based on the elution results of Cit from the nanoparticles, two-stepwise (i.e., initially dramatic and subsequentially gradual) elution behavior during the immersion was observed, which was mainly driven by the substitutional coordination of HPO42-and CO32-to the Cit ions on the nanoparticle surfaces. The Cit elution behavior by the immersion was effectively affected by the anions in the biological solutions. The substitutional coordination of HPO42-or CO32-to the Cit ions was the dominant driving force for the Cit ion elution chelating with Eu3+and Ca2+ions, which progressed significantly at the immersion time of 0-3 h in SBF. Subsequently, the complex reactions based on the substitutional coordination would become the equilibrium state at the immersion time of 3-12 h in SBF, suggesting the control of nanoparticle surface states by optimizing the Cit elution behavior. Therefore, we believe that the nanoparticles will be the base nanobiomaterials toward the application for drug delivery system carriers containing both photoluminescence and drug loading functions.

    DOI: 10.1021/acs.iecr.2c01178

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  • Effective Immobilization of Monomeric Methylene Blue on Hydroxyapatite Nanoparticles by Controlling Inorganic–Organic Interfacial Interactions Reviewed

    Iori Yamada, Takuya Kataoka, Ryota Ikeda, Sadaki Samitsu, Motohiro Tagaya

    Inorganic Chemistry   61 ( 12 )   4865 - 4878   2022.3

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    Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    We successfully synthesized methylene blue (MB+)-immobilized hydroxyapatite (HM) nanoparticles by changing the initial P/Ca molar ratio. The immobilized amount of MB+increased with increasing the initial P/Ca molar ratio from 0.6 to 4.0, and the HM had an elliptical shape (long length, 21-24 nm; short length, 11-13 nm) irrespective of the initial P/Ca molar ratio. Upon increasing the initial P/Ca molar ratio, the number of carbonate ions on the HM surface decreased, which would be owing to the electrostatic repulsion by the surface phosphate ions (i.e., P-O-), the surface P-OH mainly dissociated to form P-O-, and the electrostatic interaction of P-O-with MB+enhanced. The bonding of MB+with surface P-OH and Ca2+sites of hydroxyapatite would be hydrogen-bonding and Lewis acid-base interactions, respectively. The optimum synthesis condition for MB+immobilization at the monomer state was found to be the initial P/Ca molar ratio of 2.0. Here, the existence percentage of the MB+monomer and the molecular occupancy of the surface carbonate ion at the initial P/Ca molar ratio of 2.0 were higher than those at 4.0 with no significant difference in the immobilized amount of MB+, indicating that MB+at the initial P/Ca molar ratio of 4.0 is more aggregated than that at 2.0. These results suggested that a part of carbonate ions has a role as a spacer to suppress MB+aggregation. Accordingly, the interfacial interactions between the MB+monomer and the hydroxyapatite surface were clarified, which can effectively be controlled by the initial P/Ca molar ratio. These findings will provide fundamental and useful knowledge for the design of calcium phosphate-organic nanohybrids. We believe that these particles will be the base materials to realize diagnostic and/or therapeutic functions through the molecular state control by optimizing the synthesis conditions.

    DOI: 10.1021/acs.inorgchem.1c03569

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  • Coordination State Control of Citric Acid Molecules on Europium(III) Ion-Doped Hydroxyapatite Nanoparticles for Highly Efficient Photoluminescence toward Biomedical Applications Reviewed

    Takuya Kataoka, Takumi Hashimoto, Sadaki Samitsu, Zizhen Liu, Motohiro Tagaya

    ACS Applied Nano Materials   5 ( 2 )   2305 - 2315   2022.2

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    We successfully controlled the coordination states of citric acid (Cit) molecules on europium (Eu3+) ion-doped hydroxyapatite (Eu:HA) nanoparticles (NPs) by changing the feed Ca/P molar ratio at the nucleation stage and precisely investigated the effect of Cit states on the photoluminescence (PL) properties of the Cit-coordinated Eu:HA (Cit/Eu:HA) NPs. The increase in the molar ratio of (Ca + Eu) to P significantly increased the coordination amount of Cit on the Eu:HA NP surfaces. Transmission electron microscopy (TEM) observation demonstrated that with the increase in the coordination amount of Cit, the primary Cit/Eu:HA NPs with low crystallinity spherified and the aggregation among the NPs partially occurred, suggesting bond formation between the -COO-of Cit and the Ca2+(or Eu3+, K+) of Eu:HA. The Fourier transform infrared spectra demonstrated that the COO-of Cit is initially substituted with HPO42-on the Cit/Eu:HA NP surfaces, followed by electrostatic adsorption of Cit on the cations (Ca2+, Eu3+, and K+) of the NP surfaces, resulting in the increase of the Cit coordination amount. When the coordination occupancy of Cit molecules exceeded 100%, the molecules would form bonds with the cations such as -COO--Ca2+(or Eu3+or K+)-COO-on the surfaces in the bimolecular coordination state, which was observed as an amorphous surface layer by TEM. In the cation-rich surface environment during NP formation, the existence of the excess Ca2+, Eu3+, and K+ions would be enhanced on the NP surfaces while interacting with COO-in addition to the inclusion state inside the Eu:HA structures. Moreover, the surface Cit layer containing Eu3+formed on the NP surfaces contributed to the effective increase in the PL intensity area and the internal quantum efficiency for biomedical applications.

    DOI: 10.1021/acsanm.1c03999

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  • Nanostructural control of transparent hydroxyapatite nanoparticle films using a citric acid coordination technique Reviewed

    Zizhen Liu, Takuya Kataoka, Sadaki Samitsu, Daisuke Kawagoe, Motohiro Tagaya

    Journal of Materials Chemistry B   10 ( 3 )   396 - 405   2022.1

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    Publishing type:Research paper (scientific journal)   Publisher:Royal Society of Chemistry (RSC)  

    Control of the nanospaces of the hydroxyapatite nanoparticle films was successfully achieved using the citric acid coordination technique in a very simple way, which will provide a convenient bioceramic film preparation process.

    DOI: 10.1039/d1tb02002a

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  • Eu3+/Na+ Co-Doping in Citric Acid-Containing Hydroxyapatite Particles and Evaluation of Their Photoluminescence Properties Reviewed

    Wanyu SHI, Takuya KATAOKA, Takumi HASHIMOTO, Zizhen LIU, Motohiro TAGAYA

    Material Science and Technology of Japan   58 ( 5 )   189 - 193   2021.10

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    Authorship:Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

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  • Competitive incorporation of Eu(III) and Na(I) ions into citric acid-passivated hydroxyapatite particles Reviewed

    Wanyu Shi, Takuya Kataoka, Takumi Hashimoto, Zizhen Liu, Motohiro Tagaya

    Materials Letters   304   130561 - 130561   2021.7

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    Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    Competitive incorporation of Eu3+ and Na+ ions into citric acid-passivated hydroxyapatite (Cit/HA) particles was investigated for improving the photoluminescence internal quantum yield (ηint). As a result, Eu3+/Na+-co-doped Cit/HA (Cit/HA:Eu/Na) particles were successfully synthesized to control the Eu3+ states inside/outside the HA structure. The optimum Na+ concentration would suppress the surface deactivation of the Cit/HA:Eu/Na particles, leading to the higher ηint value.

    DOI: 10.1016/j.matlet.2021.130561

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  • Preparation of Monodispersed Nanoporous Eu(III)/Titania Loaded with Ibuprofen: Optimum Loading, Luminescence, and Sustained Release Reviewed

    Takuya Kataoka, Kota Shiba, Shinya Nagata, Iori Yamada, Yadong Chai, Motohiro Tagaya

    Inorganic Chemistry   60 ( 12 )   8765 - 8776   2021.6

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    Functional nanomaterials are one of the potential carriers for drug delivery, whereas there are many prerequisites for this purpose. The carrier should be monodispersed, be fluorescent, and have a proper nanostructure to keep/release drug molecules to achieve controlled release, although preparing a nanomaterial which fulfills all the demands is still very challenging. In this paper, we show the preparation of monodispersed nanoporous amorphous titania submicron particles with fluorescent property. They adsorb a model drug molecule - ibuprofen - with their surface coverage up to 100%. Such a perfect loading does not decrease the fluorescent intensity because of any quenching effects but even maximize it. We also demonstrate the release behavior of IBU into simulated body fluid. Interestingly, the present carrier releases most of IBU in 6 h, whereas that modified with the polyethylene glycol moiety takes 48 h to finish releasing IBU, indicating its potential for controlled release applications.

    DOI: 10.1021/acs.inorgchem.1c00718

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  • Preparation of transparent hydroxyapatite/citric acid particle films Reviewed

    Zizhen Liu, Takuya Kataoka, Daisuke Kawagoe, Daichi Noda, Yadong Chai, Motohiro Tagaya

    Colloid and Interface Science Communications   39   100316 - 100316   2020.11

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    Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    Transparent hydroxyapatite/citric acid (Cit/HA) particulate film formation and the stability in biological solution were investigated. Negatively charged Cit/HA nanoparticles were synthesized, and the particulate films were prepared by a spin-coat method through water or ethanol dispersion. As a result, the crack-free and transparent Cit/HA films were prepared from water dispersion, which exhibited the better optical properties as compared with the films prepared from ethanol dispersion. The Cit/HA films exhibited higher optical transmittance with increasing the hybridized Cit amount, and the highest transmittance in the visible light region exceeded 80%. Moreover, the calcined film had long-term stability in phosphate-buffered saline while maintaining high transparency, which is expected to be used as a candidate coating film for cell culture substrates.

    DOI: 10.1016/j.colcom.2020.100316

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  • Synthesis and photoluminescence properties of the Eu(III)-containing silica nanoparticles via a mechanochemical solid-state reaction between SiO2 and EuCl3·6H2O Reviewed

    Takumi Hashimoto, Motohiro Tagaya, Takuya Kataoka, Sunao Chatani, Masahiko Inui, Yota Higa, Satoshi Motozuka

    Advanced Powder Technology   31 ( 8 )   3650 - 3656   2020.8

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    Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    © 2020 The Society of Powder Technology Japan In this study, Eu3+-containing amorphous silica nanoparticles and Eu compounds were successfully synthesized via a mechanochemical solid-state reaction between silica nanoparticles and EuCl3·6H2O. This reaction was induced by a grinding process, and the states of Eu3+ in the silica/europium composites were investigated. The silica/europium composites exhibited orange–red color luminescence owing to the 5D0–7F0, 5D0–7F1, and 5D0–7F2 transitions, which indicated the presence of Eu3+ in the silica framework and the newly formed Eu compounds such as EuOCl and Eu(OH)2Cl. The mechanochemical reaction because of the grinding process effectively induced an interaction between the silica surface and europium chloride; subsequently, Eu(OH)2Cl was formed in the silica/europium composites. Additionally, the Eu(OH)2Cl in the silica/europium composite exhibited a higher thermal stability than that of simple Eu(OH)2Cl, indicating that the mechanochemical reaction mediated the formation of Eu(OH)2Cl and new chemical bonding between the newly formed Eu(OH)2Cl and the silica surface, providing improved thermal stability to Eu(OH)2Cl. Thus, we successfully prepared silica nanoparticles containing not only Eu(III) in the silica framework but also Eu compounds that exhibit unique chemical bonding during a mechanochemical reaction.

    DOI: 10.1016/j.apt.2020.07.013

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  • Highly Luminescent Hydroxyapatite Nanoparticles Hybridized with Citric Acid for Their Bifunctional Cell-Labeling and Cytostatic Suppression Properties Reviewed

    Takuya Kataoka, Sadaki Samitsu, Mitsuhiro Okuda, Daisuke Kawagoe, Motohiro Tagaya

    ACS Applied Nano Materials   3 ( 1 )   241 - 256   2020.1

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    We successfully prepared hybrid nanoparticles (NPs) with photofunctional interfaces between the citric acid (Cit) molecules and europium(III) ion (Eu3+)-doped hydroxyapatite (HA) (Eu:HA) to provide bifunctional cell-labeling and cytostatic suppression. In particular, the Eu:HA NPs were synthesized in the presence of Cit, and the Cit molecules were hybridized with the Eu:HA NPs (Cit/Eu:HA). The physicochemical properties based on the interfacial Eu:HA-Cit interactions in the NPs were elucidated. The atomic structures on the Eu:HA NP surface layers were disordered by increasing the liquid-solid interfaces by the interactions between the Cit molecules and the Ca site of Eu:HA NPs. It was suggested that the Cit molecules that interacted with the Eu:HA NP surfaces sterically hindered the NP growth by the inorganic-organic interactions. Moreover, it was demonstrated that the interactions of Cit as an organic molecule and Eu:HA as an inorganic matrix were important for achieving the efficient photoluminescence properties. Thus, the efficient luminescence ability including the internal efficiency for cancer cell labeling was achieved, and simultaneously, the Cit molecular effect on the suppression of the cancer cell line growth was investigated. As a result, the luminescence enhancement with the hybridization was successfully elucidated. In particular, the low symmetry of the coordination structure for the Eu3+ ion at the Ca(I) site provided the enhanced luminescence efficiency. Furthermore, the folate N-hydroxysuccinimidyl ester (FA-NHS) was immobilized on the Cit/Eu:HA NPs to enhance the uptake efficiency of the NPs into the cancer cells. Then, the cytocompatibility and the cell-labeling property were evaluated to investigate the effect of the NPs on the cancer cell growth suppression by the Cit molecules. Cancer cell growth suppression was successfully achieved by the interactions with the Cit/Eu:HA NPs. Furthermore, the Cit/Eu:HA NPs reacted with the cells to exhibit red-color luminescence from the cells while suppressing cancer cell growth, indicating the bifunction of cell-labeling and cytostatic suppression in one particle. The hybridized Cit molecules could significantly contribute to the tumorized cell (sphere) growth suppression. In particular, the Cit/Eu:HA NPs were effectively reacted with the spheres after a culture time of 60 h, and the luminescent labeling with following the cellular shapes could be achieved 1 h after NP addition, indicating the rapid labeling process with cytostatic suppression for interacting with the spheres.

    DOI: 10.1021/acsanm.9b01933

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  • Effects of surfactant removal processes from titania/octadecylamine hybrid particles on their nanostructures and dispersibility in phosphate buffered saline Reviewed

    Takuya Kataoka, Kota Shiba, Shinya Nagata, Iori Yamada, Motohiro Tagaya

    Results in Physics   13   102215 - 102215   2019.6

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    The surfactant removal from titania/octadecylamine (ODA) hybrid spherical particles through a bake treatment, solvent-extraction or their combination was investigated. The particles after removing ODA via such approaches showed spherical shape with high specific surface area ranging from 145 to 345 m(2)/g and were found to be dispersible in phosphate buffered saline. The ODA removal processes clearly influenced the particle surface states, the crystallization degrees, and the dispersibility.

    DOI: 10.1016/j.rinp.2019.102215

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  • Surface-Engineered Design of Efficient Luminescent Europium(III) Complex-Based Hydroxyapatite Nanocrystals for Rapid HeLa Cancer Cell Imaging Reviewed International journal

    Takuya Kataoka, Shigeaki Abe, Motohiro Tagaya

    ACS Applied Materials & Interfaces   11 ( 9 )   8915 - 8927   2019.3

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    We synthesized hydroxyapatite nanocrystals under the existence of tris(2,2,6,6-tetramethyl-3,5-heptanedionato)europium(III) (EuTH) complex to form inorganic/organic hybrid nanocrystal (EHA). Then, the folic acid derivative (folate N-hydroxysuccinimidyl ester (FA-NHS)) as the targeting ligand for the HeLa cancer cells was immobilized on the EHA by the mediation of both 3-aminopropyltriethoxysilane and methyltriethoxysilane molecules. Here, we investigated the photofunctions based on the interfacial interactions between the FA-NHS and EHA nanohybrids for preparing the novel bioimaging nanomaterials. As a result, the photofunctions could be changed by the FA-NHS molecular occupancy on the EHA. When the molecular occupancy ratio to the EHA surfaces is at around 3-5%, the intense luminescence from the f-f transition of the Eu3+ ions as well as the charge transfer between the EuTH-FA-NHS was observed to exhibit higher quantum efficiency. Moreover, effective dispersibility in phosphate-buffered saline was confirmed with immobilizing the positively charged FA-NHS. The cytotoxicity against the HeLa cells was also evaluated to verify whether the nanohybrids can be the candidate for cell imaging. The affinity and noncytotoxicity between the FA-NHS-immobilized EHA nanohybrids and cells were monitored for 3 days. Red luminescence from the cells could be observed, and the labels with following the cellular shapes were achieved by an additional culture time of 1 h after injecting the FA-NHS-immobilized EHA nanohybrids to the spheres, indicating the rapid bioimaging process. Therefore, this is the first successful report to describe the synthesis of inorganic-organic nanohybrid systems for controlling the EuTH-FA-NHS interactions. The photofunction of the interfacial interactions was successfully designed to provide "efficient luminescent ability" as well as "rapid targeting to the cancer cells" in one particle.

    DOI: 10.1021/acsami.8b22740

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  • Preparation of calcium phosphate nanoparticles hybridized with europium(III) complex for novel luminescent organic-inorganic systems Reviewed

    Takuya Kataoka, Kenji Shinozaki, Shigeaki Abe, Motohiro Tagaya

    Journal of Physics and Chemistry of Solids   122   218 - 226   2018.11

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    We have synthesized novel inorganic-organic hybrid systems based on the interactions between calcium phosphate (CP) and tris(2,2,6,6-tetramethyl-3,5-heptanedionato)europium (III) (EuTH) complex to clarify the states of the EuTH molecules. We achieved the nucleation and crystal growth of electronically localized of EuTH molecules using two different synthetic processes (based on the timing of the addition EuTH before and after the CP nucleation stage). The coordination environment of the Eu3+ ion inside/on the hybrids was clearly changed, having the higher spatial symmetry states in the hybrid. The aspect ratios of the hybrid crystallites were 2.5-6.0, suggesting that the EuTH molecules selectively interacted with the a-plane of the CP nuclei to induce preferential crystal growth along with the uncovered c-plane. The segregated EuTH molecules on CP surfaces suppressed Ca2 + dissolution from the hybrids in phosphate buffer saline. In the excitation spectra of the hybrids, the F-7(0) -> L-5(6) transition appeared as a result of the interaction between the EuTH and phosphate ions, suggesting that the phosphate ions affected the coordination environment. In the luminescence spectra of the hybrids, the luminescence intensity ratio of the magnetic dipole transition (D-5(0) -> (7)Fi) to electric dipole transition (D-5(0) -> F-7(2)) were higher than those of EuTH and the other Eu3+-doped inorganic systems. Thus, the higher spatial symmetry states of the Eu3+ ion in the hybrids resulted in greater luminescence intensities and quantum efficiencies, which would be affected by the phosphorus anti-quenching. In the future, CP hybrids with various organic complexes will be prepared, and these could be applied in the biomedical fields such as in bio-imaging and drug delivery systems.

    DOI: 10.1016/j.jpcs.2018.06.031

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  • Synthesis of Europium(III) Complex-Based Hydroxyapatite Nanocrystals for Biolabeling Applications Reviewed

    Takuya Kataoka, Shigeaki Abe, Motohiro Tagaya

    Key Engineering Materials   782   41 - 46   2018.10

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)   Publisher:Trans Tech Publications, Ltd.  

    We synthesized the inorganic/organic hybrid nanocrystal (EHA) by hydroxyapatite (HA) nanocrystal growth under the existence of tris(2,2,6,6-tetramethyl-3,5-heptanedionato)europium(III) (EuTH) complex. Then, folic acid derivative (FA-NHS: folate N-hydroxysuccinimidyl ester) as the targeting ligand for the HeLa cancer cells was immobilized on the EHA by the mediation of 3-aminopropyltriethoxysilane (APTES) and methyltriethoxysilane (MTES). When the FA-NHS molecular occupancy ratio on the EHA surface is around 3 to 5 %, the strong luminescence from the f-f transition of the Eu3+ ion and luminescence associated with energy transfer between the EuTH-FA monomer near 518 nm were observed. Moreover, the dispersibility in phosphate buffer saline was confirmed with immobilizing the positively-charged FA-NHS. The affinity and non-cytotoxicity between the nanocrystals and HeLa cancer cells were confirmed for 3 days. The red luminescence from the cells could be observed by fluorescence microscopy and the luminescence spectra.

    DOI: 10.4028/www.scientific.net/kem.782.41

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  • An investigation into nanohybrid states of europium (III) complex with hydroxyapatite nanocrystals Reviewed

    Takuya Kataoka, Kota Shiba, Motohiro Tagaya

    Optical Materials   84   252 - 258   2018.10

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    We synthesized the novel inorganic-organic nanohybrid systems in hydroxyapatite (HA) nanocrystal growth processes under the presence of tris(2,2,6,6-tetramethyl-3,5-heptanedionato)europium (HI) (EuTH) complex for the first time. The nanohybrid states were successfully controlled by the EuTH concentration to Ca ions in HA. The morphology of the HA was observed by a transmission electron microscope and the nanocrystalline aspect ratios were estimated to be 2.5-4.8. The segregated EuTH molecules on the HA nanocrystals covered over the aplane in HA, leading to the effective crystal growth along with the uncovered c-plane. The luminescence properties of the nanohybrids were different from that of the EuTH itself in the solution and solid states, indicating the unique Eu3+ ion states on the HA nanocrystals because of the different ligand field symmetry. Moreover, the relative luminescence intensity ratio based on the D-5(0) -> F-7(1) and D-5(0) -> F-7(2) transitions in the nanohybrid became lower with increasing the EuTH concentration, suggesting that the hybridization lowered the coordination environment symmetry of Eu3+ ion. The luminescence intensity and quantum efficiency of the nanohybrids were higher than that of the EuTH itself. Therefore, the interaction at EuTH-HA interface as well as between EuTH-EuTH molecules significantly changed by the inorganic-organic hybridization under different EuTH concentrations. In future, the present hybridization technique can be applied for preparing the nanohybrids with various metallic complexes.

    DOI: 10.1016/j.optmat.2018.07.014

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  • Preparation of Eu(iii) acetylacetonate-doped well-defined titania particles with efficient photoluminescence properties Reviewed International journal

    Kota Shiba, Takuya Kataoka, Motohiro Tagaya

    Dalton Transactions   47 ( 6 )   1972 - 1980   2018

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Royal Society of Chemistry (RSC)  

    <p>Eu(<sc>iii</sc>) acetylacetonate-doped well-defined titania particles were synthesized to demonstrate composition dependent efficient luminescence properties.</p>

    DOI: 10.1039/c7dt03035e

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  • Hybrid preparation of terbium(iii)-doped mesoporous silica particles with calcium phosphates Reviewed

    T. Kataoka, K. Shiba, L. Y. Wang, S. Yamada, M. Tagaya

    RSC Advances   7 ( 32 )   19479 - 19485   2017

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)   Publisher:Royal Society of Chemistry (RSC)  

    <p>Terbium-doped mesoporous silica/calcium phosphate interfacial hybrid particles were prepared to demonstrate characteristic luminescence behavior.</p>

    DOI: 10.1039/c6ra28457d

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  • Incorporation of terbium(III) ion into mesoporous silica particles Reviewed

    Takuya Kataoka, Liyin Wang, Kouhei Kobayashi, Masami Nishikawa, Motohiro Tagaya

    Japanese Journal of Applied Physics   55 ( 10 )   105503 - 105503   2016.10

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:IOP Publishing  

    Terbium(III)-doped mesoporous silicas were synthesized, and the states of terbium ions in the silica frameworks were investigated. The mesopores were preserved upon doping at terbium ion molar concentrations relative to (Si+Tb) up to 15 mol %, indicating the interaction of terbium ions with Si–O bonds. Significant morphological changes of the particles were observed with increasing the doping concentration. The shapes of the photoluminescence spectra due to the transitions of 5D<inf>4</inf>→ 7F<inf>6</inf>and 5D<inf>4</inf>→ 7F<inf>5</inf>were indicative of the presence of terbium ions in the silica matrix, and the quantum efficiency (2.1–2.8%) and lifetime (1.6–1.9 ms) decreased with increasing the doping concentration up to 15 mol %. Therefore, the terbium ions are considered to be located inside the amorphous silica frameworks, where they electrostatically interact with the O atoms of silanol and siloxane groups.

    DOI: 10.7567/jjap.55.105503

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  • Preparation of europium(III)-doped hydroxyapatite nanocrystals in the presence of cationic surfactant Reviewed

    Takuya Kataoka, Kota Shiba, Motohiro Tagaya

    Colloid and Interface Science Communications   13   1 - 5   2016.7

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    Europium (III) (Eu3+)-doped hydroxyapatite (HAp) nanocrystals were synthesized in the presence of a cetyltrimethylammoniumbromide (CTAB) to investigate the states of Eu3+ ions in the structure. The HAp structure was preserved with the doping as well as the CTAB existence, and the carbonate ions were included in the structure. The uniformshapes andmono-dispersion of the nanocrystals were observed by adding CTAB. The transitions of D-5(0)-F-7(1) and D-5(0)-F-7(2) in the photoluminescence spectra indicated the presence of the Eu3+ in an environment of a low symmetry before the calcination. The Eu3+ was effectively positioned in the Ca sites in the HAp structure. The CTAB addition would prevent the Eu3+ ions from aggregating each other, inducing the effective substitution and resultantly showing the efficient luminescence. Therefore, the interactions between the Eu3+ ions and HAp structure were successfully enhanced in the presence of CTAB. (C) 2016 Elsevier B.V.

    DOI: 10.1016/j.colcom.2016.04.003

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  • Effect of Cationic Surfactant Micelles on Hydroxyapatite Nanocrystal Formation: An Investigation into the Inorganic–Organic Interfacial Interactions Reviewed

    Kota Shiba, Satoshi Motozuka, Tadashi Yamaguchi, Nobuhiro Ogawa, Yuichi Otsuka, Kiyoshi Ohnuma, Takuya Kataoka, Motohiro Tagaya

    Crystal Growth & Design   16 ( 3 )   1463 - 1471   2016.3

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    © 2016 American Chemical Society. To clarify hydroxyapatite (HAp) nanocrystal formation based on the interfacial interactions with organic molecules is important for controlling the dispersion states/shapes of HAp and understanding the biomineralization mechanism. In this study, the effects of cetyltrimethylammonium bromide (CTAB) micelles on the HAp nanocrystal formation process were investigated through both the morphosynthesis technique and the molecular orbital calculations. The HAp nanocrystals synthesized in the presence of CTAB exhibited a controlled rod-like shape and subsequently grew up by a thermal treatment to be larger-sized nanocrystals at a well-dispersed state. It was also found that the CTAB micelles strained and disordered at the higher temperature effectively induced heterogeneous nucleation to initiate the nucleation/growth processes. In contrast, HAp nanocrystals synthesized without CTAB exhibited irregular-shaped and aggregated nanocrystals, which are due to dominantly occurring homogeneous nucleation. According to the molecular orbital calculations, the cationic N atom of the CTAB molecule strongly interacted with the Ca ion in the a-plane as well as the hydroxyl/phosphate groups in the c-plane of HAp via ionic/covalent bonding (e.g., only ionic bonding at the closer interfacial distance at 1.0 Å), leading to effective nucleation on the micelle surfaces. Therefore, a possible reason for the rod-like and well-dispersed nanocrystal formation is due to the heterogeneous nuclei formation/growth on the N atoms of CTAB micelles and subsequent fusion growth among the CTAB micelle-directed inorganic-organic complexes in the confined spaces. The present results will be applicable for designing tailored HAp morphologies based on inorganic-organic hybrid interaction systems.

    DOI: 10.1021/acs.cgd.5b01599

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  • Preparation of nanocrystalline zinc-substituted hydroxyapatite films and their biological properties Reviewed

    Tania Guadalupe Peñaflor Galindo, Takuya Kataoka, Shuji Fujii, Mitushiro Okuda, Motohiro Tagaya

    Colloid and Interface Science Communications   10-11   15 - 19   2016.1

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    DOI: 10.1016/j.colcom.2016.03.005

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  • Designed synthesis of well-defined titania/iron(iii) acetylacetonate nanohybrids with magnetic/luminescent properties Reviewed

    Kota Shiba, Takuya Kataoka, Mitsuhiro Okuda, Santiago Blanco-Canosa, Motohiro Tagaya

    RSC Advances   6 ( 61 )   55750 - 55754   2016

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Royal Society of Chemistry (RSC)  

    <p>Synthesis and magnetic/luminescent properties of well-defined titania/octadecylamine/iron(<sc>iii</sc>) acetylacetonate hybrid functional particles were demonstrated.</p>

    DOI: 10.1039/c6ra03824g

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  • Morphosynthesis of Zn-Substituted Stoichiometric and Carbonate Hydroxyapatite Nanoparticles and Their Cytotoxicity in Fibroblasts Reviewed

    Tania Guadalupe Peñaflor Galindo, Takuya Kataoka, Motohiro Tagaya

    Journal of Nanomaterials   2015   1 - 8   2015

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    Hydroxyapatite (Ca10(PO4)3(OH)2) (HAp) is crystallographically and chemically similar to the human hard tissues and has been widely researched. The naturally formed HAp has some impurities of some ions, which provides the biocompatibility as well as the nanosized morphologies in the tissues. In this study, the morphosynthesis of zinc-substituted stoichiometric and carbonate hydroxyapatite (Zn:HAp and Zn:CAp) nanoparticles was investigated from the reagents of CaCl2, ZnCl2, and K2HPO4. The initial (Ca + Zn)/P ratios of 1.67 and 2.00 were adjusted by the initial ZnCl2amount at the Zn/(Ca + Zn) concentration of 0.0−10 mol%. The crystalline sizes of the nanoparticles decreased with increasing the Zn ion amount, suggesting that the Zn substitution significantly suppressed the crystal growth. TEM images of the nanoparticles indicated that all the crystalline sizes are less than 100 nm and the needle-like shapes were significantly changed to spherical shapes with increasing the Zn ion substitution to resultantly exhibit the higher surface areas as well as the nanoparticle aggregation states. Furthermore, all the nanoparticle films electrically plated on a silicone substrate give no cytotoxicity, and the Zn:CAp nanoparticle films significantly provided the bioactive properties for fibroblast ingrowth, suggesting the effect of Zn and carbonate ions on the cytocompatibility.

    DOI: 10.1155/2015/376045

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    Other Link: http://downloads.hindawi.com/journals/jnm/2015/376045.xml

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MISC

  • 生体に優しい強発光バイオセラミック粒子の創製

    片岡 卓也, 多賀谷 基博

    材料の科学と工学   59 ( 2 )   14 - 17   2022.4

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  • Evaluation of Singlet Oxygen Generation Ability by Methylene Blue-Adsorbed Hydroxyapatite Particles in Biological Solution

    山田伊織, 片岡卓也, 多賀谷基博

    日本セラミックス協会秋季シンポジウム講演予稿集(Web)   34th   2021

  • Synthesis of Luminescent Europium(III) Complex-based Hydroxyapatite Nanoparticles and Their Rapid Cell Labeling by Folic Acid Immobilization

    片岡卓也, 阿部薫明, 多賀谷基博

    日本セラミックス協会年会講演予稿集(Web)   2021   2021

  • Synthesis of Silica-Titania Based Hybrid Particles for Preferentially Coordinating Methylene Blue Monomer

    藤原哉太, 片岡卓也, 山田伊織, 柴弘太, 多賀谷基博

    ナノ学会大会講演予稿集   19th   2021

  • Preparation of Citric Acid-Containing Hydroxyapatite Particle Films and Evaluation of Their Cell Culture Ability

    LIU Z., 片岡卓也, 片岡卓也, 川越大輔, 多賀谷基博

    日本セラミックス協会秋季シンポジウム講演予稿集(Web)   34th   2021

  • Introduction of Aluminum(III)quinoline Complex into Phosphoric Acid-containing Mesoporous Silica Particles

    倉上友里, 片岡卓也, 多賀谷基博

    ナノ学会大会講演予稿集   19th   2021

  • Synthesis of hydroxyapatite particles supporting methylene blue and their singlet oxygen generation ability evaluation

    池田遼太, 片岡卓也, 山田伊織, 多賀谷基博

    日本セラミックス協会年会講演予稿集(Web)   2021   2021

  • Synthesis of Eu(III)-ion-doped Hydroxyapatite Particles Coordinated with Citric Acid and Evaluation of Their Surface Reactivity in Simulated Body Fluid

    橋本拓実, 片岡卓也, 片岡卓也, 多賀谷基博

    日本セラミックス協会年会講演予稿集(Web)   2021   2021

  • Film Formation of Hydroxyapatite Particles Coordinated with Citric Acid and Evaluation of Their Stabilization in Biological Solution

    LIU Z., 片岡卓也, 川越大輔, 多賀谷基博

    日本セラミックス協会年会講演予稿集(Web)   2021   2021

  • Synthesis of Luminescent Hydroxyapatite Nanoparticles Coordinated with Citric Acid for Their Bifunctional Cell-Labeling and Cytostatic Suppression Properties

    片岡卓也, 佐光貞樹, 多賀谷基博

    日本セラミックス協会年会講演予稿集(Web)   2021   2021

  • Synthesis of Photofunctional Bioceramic Particles and Their Biomedical Applications

    Ceramics Japan = セラミックス : bulletin of the Ceramic Society of Japan   55 ( 12 )   885 - 889   2020

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  • Synthesis of hydroxyapatite nanoparticles with bifunctions of labeling and growth inhibition for specific cells

    片岡卓也, 多賀谷基博

    日本セラミックス協会秋季シンポジウム講演予稿集(CD-ROM)   33rd   2020

  • Synthesis and characterization of hydroxyapatite/methylene blue hybrid particles with photosensitizing ability

    池田遼太, 片岡卓也, 山田伊織, 多賀谷基博

    日本セラミックス協会秋季シンポジウム講演予稿集(CD-ROM)   33rd   2020

  • Preparation of transparent films made of hydroxyapatite particles containing citric acid and their evaluation of solvent resistance to biological solution

    LIU Z., 片岡卓也, 川越大輔, 多賀谷基博

    日本セラミックス協会秋季シンポジウム講演予稿集(CD-ROM)   33rd   2020

  • Microfluidic synthesis of hydroxyapatite/methylene blue hybrid nanoparticles and their photoreactivity evaluation

    池田遼太, 片岡卓也, 片岡卓也, 山田伊織, 多賀谷基博

    日本セラミックス協会年会講演予稿集(CD-ROM)   2020   2020

  • メチレンブルー担持ハイドロキシアパタイト粒子の合成と可視光照射に伴う一重項酸素生成能の評価

    池田遼太, 片岡卓也, 片岡卓也, 山田伊織, 山田伊織, 多賀谷基博

    固体・表面光化学討論会講演要旨集   39th (Web)   2020

  • Preparation of Transparent Hydroxyapatite Thin Film by Addition of Citric Acid

    松沼佳南, 片岡卓也, 片岡卓也, 多賀谷基博, 川越大輔

    日本セラミックス協会年会講演予稿集(CD-ROM)   2020   2020

  • Preparation of hydroxyapatite particle dispersion liquid containing citric acid and the development of transparent film formation

    LIU Z., 片岡卓也, 片岡卓也, 川越大輔, 多賀谷基博

    日本セラミックス協会年会講演予稿集(CD-ROM)   2020   2020

  • Synthesis of luminescent apatite nanoparticles with bifunctions of labeling and growth inhibition for cancer cells

    片岡卓也, 片岡卓也, 多賀谷基博

    日本セラミックス協会年会講演予稿集(CD-ROM)   2020   2020

  • Eu(III)イオン含有ハイドロキシアパタイト粒子合成におけるクエン酸配位効果の解明

    橋本拓実, 片岡卓也, 片岡卓也, 多賀谷基博

    固体・表面光化学討論会講演要旨集   39th (Web)   2020

  • Design of Hydroxyapatite-Based Multifunctional Nanoparticles for Cell Labelling and Cell Growth Inhibition

    Takuya Kataoka, Kota Shiba, Motohiro Tagaya

    Regenerative Medicine Frontiers   2 ( 1 )   2019

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    DOI: 10.20900/rmf20200001

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  • Interfacial interaction evaluation between cationic surfactant/hydroxyapatite and the development for europium(III)-containing photoluminescent nanomaterials

    片岡卓也, 片岡卓也, 本塚智, 柴弘太, XU Zhefeng, 多賀谷基博

    DV-Xα研究協会会報   31 ( 1-2 )   2019

  • クエン酸を含有した発光性アパタイトナノ結晶の新規開発

    片岡卓也, 片岡卓也, 多賀谷基博

    日本セラミックス協会年会講演予稿集(CD-ROM)   2019   2019

  • メチレンブルー担持ナノポーラスチタニア粒子への光照射に伴う一重項酸素生成能の評価

    池田遼太, 山田伊織, 永田真也, 片岡卓也, 角田正也, 多賀谷基博

    日本セラミックス協会年会講演予稿集(CD-ROM)   2019   2019

  • 無機-有機ナノ複合技術による透明アパタイト膜の作製

    LIU Z., 片岡卓也, 片岡卓也, 多賀谷基博

    日本セラミックス協会年会講演予稿集(CD-ROM)   2019   2019

  • Preparation of Hydroxyapatite/Dye Hybrid Structures and Their Physicochemical Properties

    Phosphorus letter   ( 91 )   31 - 35   2018.2

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  • 生体機能化を目指した異種材料ナノハイブリッドの創製

    金属   88 ( 1 )   15 - 22   2018

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  • 炭酸含有水酸アパタイトの結晶形成過程における蛍光色素の複合化

    尾上和寛, 片岡卓也, 多賀谷基博

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   65th   2018

  • アパタイト/Eu錯体複合粒子の葉酸誘導体修飾による光機能化

    片岡卓也, 多賀谷基博

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   65th   2018

  • 水系に分散する多孔性チタニアサブミクロン粒子の創製

    永田真也, 片岡卓也, 多賀谷基博, 柴弘太

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   65th   2018

  • 陽イオン界面活性剤と水酸アパタイトの界面相互作用解析とユウロピウム(III)含有発光ナノ材料への応用

    片岡 卓也, 本塚 智, 柴 弘太, 許 哲峰, 多賀谷 基博

    DV-Xα研究会会報   29 ( 1&2 )   147 - 151   2017.3

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    J-GLOBAL

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  • ナノ多孔質シリカ/水酸アパタイト複合粒子の合成とタンパク質相互作用の評価

    山田翔太, 片岡卓也, 多賀谷基博

    日本セラミックス協会年会講演予稿集(CD-ROM)   2017   2017

  • 水酸アパタイト/有機ユウロピウム(III)錯体の複合構造構築と物性評価

    片岡卓也, 多賀谷基博

    無機リン化学討論会講演要旨集   26th   2017

  • リン酸含有メソポーラスシリカへのアルミニウム(III)キノリン錯体の導入

    倉上友里, 片岡卓也, 多賀谷基博

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   64th   2017

  • 陽イオン界面活性剤ミセルによる水酸アパタイトの核形成/成長制御とDV-Xα計算による界面相互作用解析

    片岡卓也, 柴弘太, 本塚智, 小川展弘, 山口正, 大沼清, 大塚雄市, XU Zhefeng, 多賀谷基博

    DV-Xα研究協会会報   28 ( 1-2 )   2016

  • 界面活性剤ミセル存在下における発光性水酸アパタイトナノ結晶の合成と特性

    片岡卓也, 柴弘太, 多賀谷基博

    応用物理学会春季学術講演会講演予稿集(CD-ROM)   63rd   2016

  • Eu(III)錯体を核形成場とした有機/リン酸カルシウム複合粒子の創製

    片岡卓也, 多賀谷基博

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   77th   2016

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Presentations

  • The application of alternating-current electrophoresis to the deposition of ceramic/polymer-nanofiber composites on metallic materials for orthodontics

    Tomohiko Yoshioka, Yumi Yoshiki, Hinako Takata, Takuya Kataoka, Eiji Fujii, Kanji Tsuru, Satoshi Hayakawa

    12th World Biomaterials Congress (WBC2024), P4-329, Daegu, Korea  2024.5.30 

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  • 交流電解ゾル-ゲル反応によるシリカゲルへの酵素固定化と活性評価

    吉岡 朋彦, 谷口 功治, 片岡 卓也, 早川 聡

    日本セラミックス協会2024年年会、講演番号3H09、熊本(熊本大学)  2024.3.16 

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  • The application of alternating-current electrolysis to the sol-gel deposition of silica gel-enzyme composites

    Tomohiko Yoshioka, Koji Taniguchi, Takuya Kataoka, Satoshi Hayakawa

    MRM2023/IUMRS-ICA2023, E2-O202-03, Kyoto  2023.12.12 

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  • 電解ゾル-ゲル反応で得られたシリカゲルの固体NMRによる構造解析

    細谷 頑馬, 片岡 卓也, 吉岡 朋彦, 早川 聡

    日本セラミックス協会第25回生体関連セラミックス討論会、講演番号O-4、名古屋(名古屋工業大学)  2023.12.1 

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  • ナノ多孔性シリカ/Mg(II)含有リン酸カルシウム複合粒子の合成と評価

    廣田 大樹, 片岡 卓也, 吉岡 朋彦, 早川 聡

    第29回ヤングセラミスト・ミーティング in 中四国、講演番号K11、岡山(岡山大学)  2023.11.25 

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  • 水熱処理によるアルミノケイ酸塩ガラスへの表面微細構造の創製と光学特性の評価

    鳥居 拓真, 片岡 卓也, 吉岡 朋彦, 早川 聡

    第29回ヤングセラミスト・ミーティング in 中四国、講演番号K32、岡山(岡山大学)  2023.11.25 

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  • ケイ酸ナトリウムと共存させた酵素の活性変化

    吉岡 朋彦, 中山 七海, 城崎 由紀, 片岡 卓也, 早川 聡

    日本セラミックス協会第36回秋季シンポジウム、講演番号3A23、京都(京都工芸繊維大学)  2023.9.8 

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  • 異なる量のキトサン存在下で合成したMg(II)イオン含有アパタイト粒子の評価

    西崎 航, 安平 友飛, 片岡 卓也, 吉岡 朋彦, 藤井 英司, 早川 聡

    日本セラミックス協会第36回秋季シンポジウム、講演番号3A02、京都(京都工芸繊維大学)  2023.9.8 

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  • ジピコリン酸を含むSr(II)イオンドープリン酸八カルシウムの合成と評価

    西山 青太, 片岡 卓也, 吉岡 朋彦, 藤井 英司, 早川 聡

    日本セラミックス協会第36回秋季シンポジウム、講演番号1A16、京都(京都工芸繊維大学)  2023.9.6 

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  • 交流電気泳動堆積法を用いたアルミナ/セルロースナノファイバー複合体の作製

    高田 ひな呼, 吉岡 朋彦, 片岡 卓也, 藤井 英司, 都留 寛治, 早川 聡

    日本セラミックス協会2023年年会、講演番号2H30、横浜(神奈川大学)  2023.3.9 

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  • FT-IRを用いたケイ酸ナトリウムとタンパク質の相互作用解析

    中山 七海, 吉岡 朋彦, 城崎 由紀, 片岡 卓也, 今村 維克, 早川 聡

    日本セラミックス協会2023年年会、講演番号2H24、横浜(神奈川大学)  2023.3.9 

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  • 水熱処理による金属チタン表面へのブルッカイト型酸化チタン層の形成とin vitroアパタイト形成能の評価

    中本 優志, 片岡 卓也, 吉岡 朋彦, 早川 聡

    日本セラミックス協会基礎科学部会第61回セラミックス基礎科学討論会、講演番号2C04、岡山大学  2023.1.8 

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  • SiO2系生体活性ゲルの電気化学的作製と添加物による特性改善

    吉岡 朋彦, 前田 気悦, Gunawan, 片岡 卓也, 早川 聡

    日本セラミックス協会基礎科学部会第61回セラミックス基礎科学討論会、講演番号2C08、岡山大学  2023.1.8 

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  • アルミナ/キトサンナノファイバー複合体の交流電気泳動堆積と歯科応用

    吉木 佑実, 片岡 卓也, 吉岡 朋彦, 藤井 英司, 都留 寛治, 早川 聡

    日本セラミックス協会基礎科学部会第61回セラミックス基礎科学討論会、講演番号2C06、岡山大学  2023.1.8 

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  • 細胞足場材料としてのセルロースナノファイバーと細胞モデルの交流電気泳動堆積

    奥家 就平, 片岡 卓也, 吉岡 朋彦, 藤井 英司, 早川 聡

    日本セラミックス協会基礎科学部会第61回セラミックス基礎科学討論会、講演番号2C05、岡山大学  2023.1.8 

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  • 化学処理によるソーダ石灰ガラス表面への微細凹凸構造の形成機構と光学特性の評価

    成松 将希, 片岡 卓也, 吉岡 朋彦, 早川 聡

    日本セラミックス協会基礎科学部会第61回セラミックス基礎科学討論会、講演番号1E04、岡山大学  2023.1.7 

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  • Impact of sodium silicates on protein secondary structure analyzed using Fourier transform infrared spectroscopy

    Nanami Nakayama, Takuya Kataoka, Tomohiko Yoshioka, Yuki Shirosaki, Satoshi Hayakawa

    2023.1.7 

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  • Alternating-current electrolytic deposition of calcium phosphate coatings on titanium substrate

    Tomohiko Yoshioka, Jun Morimoto, Shun Haruki, Takuya Kataoka, Satoshi Hayakawa

    20th Asian BioCeramics Symposium (ABC2022), G-09, Toyama  2022.12.12 

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  • 化学処理によるアルミノケイ酸塩ガラス表面への微細凹凸構造の形成機構

    白髭 晃大, 片岡 卓也, 吉岡 朋彦, 早川 聡

    第28回 ヤングセラミスト・ミィーティングin中四国、講演番号K84、愛媛大学  2022.12.10 

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  • 交流電気泳動堆積法を用いた歯科矯正ワイヤーへの無機有機複合体の作製

    吉木 佑実, 片岡 卓也, 吉岡 朋彦, 藤井 英司, 都留 寛治, 早川 聡

    第28回 ヤングセラミスト・ミィーティングin中四国、講演番号K2、愛媛大学  2022.12.10 

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  • 交流電解ゾル-ゲル反応によるシリカゲルへの細胞モデルの担持挙動

    吉岡 朋彦, 鳥井 奎汰, 城崎 由紀, 片岡 卓也, 早川 聡

    日本セラミックス協会第35回秋季シンポジウム、講演番号3H22、徳島大学  2022.9.16 

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  • 水酸アパタイト/キトサン複合粒子へのMg(II)イオンの導入

    安平 友飛, 片岡 卓也, 吉岡 朋彦, 早川 聡

    日本セラミックス協会第35回秋季シンポジウム、講演番号2H04、徳島大学  2022.9.15 

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  • シリカゲルの電解ゾル-ゲル反応におけるタンパク質共存の効果

    吉岡 朋彦, 橋本 里奈, 片岡 卓也, 早川 聡

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  • 交流電解におけるpH変化とリン酸カルシウムの析出挙動

    森本 準, 吉岡 朋彦, 片岡 卓也, 早川 聡

    日本セラミックス協会2022年年会  2022.3.11 

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  • 無機/有機界面相互作用に基づく発光性アパタイトナノ粒子の創製とがん細胞標識への応用 Invited

    片岡 卓也

    第9回日本バイオマテリアル学会中四国ブロックシンポジウム  2022.2.15 

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  • 銀を担持させた生体活性ゲルの電気化学的作製

    吉岡 朋彦, Gunawan, 片岡 卓也, 早川 聡

    第43回日本バイオマテリアル学会 (43th JSB) 及び第8回アジアバイオマテリアル学会 (8th ABMC)  2021.11.29 

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  • ダブルパルス電解によるシリカゲルの形成

    吉岡 朋彦, 浅田 敏生, 片岡 卓也, 早川 聡

    日本セラミックス協会第34回秋季シンポジウム  2021.9.3 

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  • 交流電場を用いた炭酸カルシウムの電解析出

    吉岡 朋彦, 三木 麻由美, 藤井 英司, 片岡 卓也, 早川 聡

    日本セラミックス協会第34回秋季シンポジウム  2021.9.3 

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  • クエン酸含有ハイドロキシアパタイト粒子膜の創製と細胞培養特性の評価

    劉 自振, 片岡 卓也, 川越 大輔, 多賀谷 基博

    日本セラミックス協会第34回秋季シンポジウム  2021.9.2 

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  • メチレンブルー吸着ハイドロキシアパタイト粒子の生体液中における一重項酸素生成能の評価

    山田 伊織, 片岡 卓也, 多賀谷 基博

    日本セラミックス協会第34回秋季シンポジウム  2021.9.2 

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  • メチレンブルーモノマーの担持に最適なシリカ-チタニア系ハイブリッド粒子の合成

    藤原 哉太, 片岡 卓也, 山田 伊織, 柴 弘太, 多賀谷 基博

    ナノ学会第19 回大会  2021.5.21 

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  • リン酸含有メソポーラスシリカ粒子へのアルミニウム(III)キノリン錯体の担持

    倉上 友里, 片岡 卓也, 多賀谷 基博

    ナノ学会第19 回大会  2021.5.21 

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  • クエン酸配位ハイドロキシアパタイト粒子膜の調製と生体液中での安定性の評価

    劉 自振, 片岡 卓也, 川越 大輔, 多賀谷 基博

    日本セラミックス協会 2021年年会  2021.3.25 

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  • メチレンブルー担持ハイドロキシアパタイト粒子の合成と一重項酸素生成能の評価

    池田 遼太, 片岡 卓也, 山田 伊織, 多賀谷 基博

    日本セラミックス協会 2021年年会  2021.3.23 

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  • クエン酸配位Eu(III)イオンドープ水酸アパタイト粒子の合成と擬似体液における表面反応性の評価

    橋本 拓実, 片岡 卓也, 多賀谷 基博

    日本セラミックス協会 2021年年会  2021.3.23 

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  • 細胞標識能と増殖抑制能を両立するクエン酸配位発光性ハイドロキシアパタイトナノ粒子の合成

    片岡 卓也, 佐光 貞樹, 多賀谷 基博

    日本セラミックス協会 2021年年会  2021.3.23 

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  • Eu(III)錯体を含有したハイドロキシアパタイトナノ粒子の合成と葉酸修飾による細胞標識機能化

    片岡 卓也, 阿部 薫明, 多賀谷 基博

    日本セラミックス協会 2021年年会  2021.3.23 

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  • クエン酸配位 Eu(III)ドープ水酸アパタイト粒子合成における炭酸水素ナトリウム添加効果の解明

    石 婉玉, 橋本 拓実, 片岡 卓也, 劉 自振, 多賀谷 基博

    日本バイオマテリアル学会 2020年度北信越ブロック研究発表会  2021.1.19 

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  • Eu(III)イオン含有ハイドロキシアパタイト粒子合成におけるクエン酸配位効果の解明

    橋本 拓実, 片岡 卓也, 多賀谷 基博

    第39回固体・表面光化化学討論会  2020.11.13 

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  • メチレンブルー担持ハイドロキシアパタイト粒子の合成と可視光照射に伴う一重項酸素生成能の評価

    池田 遼太, 片岡 卓也, 山田 伊織, 多賀谷 基博

    第39回固体・表面光化化学討論会  2020.11.13 

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  • Effect of Citric Acid Addition on Hydroxyapatite Slurry State for Forming Transparent Thin Film

    Natsuki Horikoshi, Aki Hatanaka, Disuke Kawagoe, Kanan Matsunuma, Zizhen Liu, Takuya Kataoka, Motohiro Tagaya

    STI-gigaku  2020.10.30 

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  • 光増感能を有する水酸アパタイト/メチレンブルー複合粒子の合成と評価

    池田 遼太, 片岡 卓也, 山田 伊織, 多賀谷 基博

    日本セラミックス協会第33回秋季シンポジウム  2020.9.4 

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  • 透明クエン酸含有ハイドロキシアパタイト粒子膜の調製と生体液中での安定性の評価

    劉 自振, 片岡 卓也, 川越 大輔, 多賀谷 基博

    日本セラミックス協会第33回秋季シンポジウム  2020.9.3 

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  • 特定細胞の標識能と増殖抑制能を両立する水酸アパタイトナノ粒子の創製

    片岡 卓也, 多賀谷 基博

    日本セラミックス協会第33回秋季シンポジウム  2020.9.3 

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  • がん細胞の標識と増殖抑制を両立する発光性アパタイトナノ粒子の創製

    片岡 卓也, 多賀谷 基博

    日本セラミックス協会 2020年年会  2020.3.19 

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  • クエン酸添加による水酸アパタイト透明薄膜の作製

    松沼 佳南, 片岡 卓也, 多賀谷 基博, 川越 大輔

    日本セラミックス協会 2020年年会  2020.3.18 

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  • クエン酸含有ハイドロキシアパタイト粒子分散液の調製と透明膜形成への展開

    劉 自振, 片岡 卓也, 川越 大輔, 多賀谷 基博

    日本セラミックス協会 2020年年会  2020.3.18 

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  • マイクロ流路を用いた水酸アパタイト/メチレンブルー複合ナノ粒子の合成と光反応性の評価

    池田 遼太, 片岡 卓也, 山田 伊織, 多賀谷 基博

    日本セラミックス協会 2020年年会  2020.3.18 

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  • クエン酸含有Eu(III)イオンドープ水酸アパタイトの合成温度と発光特性に関する研究

    橋本 拓実, 片岡 卓也, 本塚 智, 多賀谷 基博

    日本バイオマテリアル学会北陸信越ブロック第8回若手研究発表会  2019.12.6 

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  • マイクロ流路を用いた水酸アパタイトナノ粒子へのメチレンブルー複合化技術の開発

    池田 遼太, 片岡 卓也, 山田 伊織, 多賀谷 基博

    日本バイオマテリアル学会北陸信越ブロック第8回若手研究発表会  2019.12.6 

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  • クエン酸含有ハイドロキシアパタイト粒子分散液の調製と透明膜形成技術への展開

    劉 自振, 片岡 卓也, 川越 大輔, 多賀谷 基博

    日本バイオマテリアル学会北陸信越ブロック第8回若手研究発表会  2019.12.6 

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  • 発光性ナノポーラスチタニア粒子の合成と薬物担持能の評価

    永田 真也, 片岡 卓也, 柴 弘太, 多賀谷 基博

    日本材料科学会 第26回若手研究者討論会  2019.12.6 

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  • Design of Photoluminescent Hydroxyapatite Nanoparticles Interacting Citric acid and Their Cell-labeling and Cytostatic Suppression Functions

    Takuya Kataoka, Daisuke Kawagoe, Motohiro Tagaya

    STI-gigaku  2019.11.8 

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  • Transparent Thin Film Hydroxyapatite by Addition of Citric Acid on Glass Surface

    Kanan Matsunuma, Disuke Kawagoe, Takuya Kataoka, Takumi Hashimoto, Motohiro Tagaya

    STI-gigaku  2019.11.8 

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  • クエン酸を含有した発光性アパタイトナノ結晶の新規開発

    片岡 卓也, 多賀谷 基博

    日本セラミックス協会 2019年年会  2019.3.26 

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  • メチレンブルー担持ナノポーラスチタニア粒子への光照射に伴う一重項酸素生成能の評価

    池田 遼太, 山田 伊織, 永田 真也, 片岡 卓也, 角田 正也, 多賀谷 基博

    日本セラミックス協会 2019年年会  2019.3.26 

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  • 無機-有機ナノ複合技術による透明アパタイト膜の作製

    劉 自振, 片岡 卓也, 多賀谷 基博

    日本セラミックス協会 2019年年会  2019.3.26 

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  • サブミクロンチタニア粒子へ含有した有機Eu錯体の洗浄除去性能の評価

    永田 真也, 柴 弘太, 片岡 卓也, 多賀谷 基博

    日本バイオマテリアル学会北陸信越ブロック第7回若手研究発表会  2018.12.11 

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  • 水酸アパタイト/Eu錯体複合粒子への葉酸誘導体固定と細胞標識機能化

    片岡 卓也, 多賀谷 基博

    日本セラミックス協会 第22回生体関連セラミックス討論会  2018.11.30 

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  • Synthesis of Europium(III) Complex-based Hydroxyapatite Nanocrystals for Biolabeling Applications

    Takuya Kataoka, Motohiro Tagaya

    Bioceramics 30  2018.10.27 

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  • カチオン性界面活性剤と水酸アパタイトの界面相互作用評価とユウロピウム(III)含有発光ナノ材料への展開

    片岡 卓也, 本塚 智, 柴 弘太, 許 哲峰, 多賀谷 基博

    第31回DV-Xα研究会  2018.8.3 

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  • Photoluminescent and biocompatible property of folic acid derivative immobilized apatite/Eu-complex hybrid particles for biomedical tool

    Shigeaki Abe, Takuya Kataoka, Motohiro Tagaya

    NANO KOREA 2018  2018.7.11 

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  • 炭酸含有水酸アパタイトの結晶形成過程における蛍光色素の複合化

    尾上 和寛, 片岡 卓也, 多賀谷 基博

    第65回応用物理学会関係連合講演会  2018.3.20 

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  • 水系に分散する多孔性チタニアサブミクロン粒子の創製

    永田 真也, 片岡 卓也, 多賀谷 基博, 柴 弘太

    第65回応用物理学会関係連合講演会  2018.3.20 

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  • アパタイト/Eu錯体複合粒子の葉酸誘導体修飾による光機能化

    片岡 卓也, 多賀谷 基博

    第65回応用物理学会関係連合講演会  2018.3.18 

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  • 水酸アパタイト/有機ユウロピウム(Ⅲ)錯体の複合構造構築と物性評価

    片岡 卓也, 多賀谷 基博

    日本無機リン化学会 第二十六回無機リン化学討論会  2017.8.24 

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  • 有機Eu(III)錯体/水酸アパタイト複合ナノ結晶の創製と 表面修飾技術の確立

    片岡 卓也, 多賀谷 基博

    日本セラミックス協会 第4回ナノバイオセラミックスによる細胞機能制御テクノロジー研究会  2017.6.16 

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  • ナノ多孔質シリカ/水酸アパタイト複合粒子の合成とタンパク質相互作用の評価

    山田 翔太, 片岡 卓也, 多賀谷 基博

    日本セラミックス協会 2017年年会  2017.3.19 

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  • リン酸含有メソポーラスシリカへのアルミニウム(III)キノリン錯体の導入

    倉上 友里, 片岡 卓也, 多賀谷 基博

    第65回応用物理学関係連合講演会  2017.3.15 

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  • 細胞親和性を有する有機金属錯体/リン酸カルシウム複合ナノ結晶の創製

    片岡 卓也, 多賀谷 基博

    第5回日本バイオマテリアル学会北陸若手研究発表会  2016.12.9 

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  • 魚ウロコからの多孔質水酸アパタイトの合成と評価

    柴 亜東, 片岡 卓也, 山田 翔太, 小林 幸平, 小川 展弘, 多賀谷 基博

    第5回日本バイオマテリアル学会北陸若手研究発表会  2016.12.9 

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  • 有機Eu錯体とリン酸カルシウムのハイブリッド化技術の開発

    片岡 卓也, 多賀谷 基博

    日本セラミックス協会 第3回ナノバイオセラミックスによる細胞機能制御テクノロジー研究会  2016.12.8 

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  • 魚ウロコ・水酸アパタイト多孔質材料の創製

    柴 亜東, 片岡 卓也, 山田 翔太, 小林 幸平, 小川 展弘, 多賀谷 基博

    日本セラミックス協会 第3回ナノバイオセラミックスによる細胞機能制御テクノロジー研究会  2016.12.8 

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  • 細胞親和性に優れた有機Eu錯体/リン酸カルシウム複合ナノ結晶の創製

    片岡 卓也, 多賀谷 基博

    日本セラミックス協会 第20回生体関連セラミックス討論会  2016.12.2 

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  • Eu(III)錯体を核形成場とした有機/リン酸カルシウム複合粒子の創製

    片岡 卓也, 多賀谷 基博

    第77回応用物理学会秋季学術講演会  2016.9.16 

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  • 陽イオン界面活性剤を活用した発光性水酸アパタイトナノ材料の創製

    片岡 卓也, 多賀谷 基博

    日本材料科学会 第23 回若手研究者討論会  2016.8.21 

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  • 陽イオン界面活性剤と水酸アパタイトの界面相互作用解析とユウロピウム(III)含有発光ナノ材料への応用

    片岡 卓也, 本塚 智, 柴 弘太, 許 哲峰, 多賀谷 基博

    第29回DV-Xα研究会  2016.8.8 

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  • Preparation of Hybrid Luminescent Mesoporous Silica Particles with Calcium Phosphate

    Takuya Kataoka, Liyin Wang, Yuri Maruko, Kouhei Kobayashi, Motohiro Tagaya

    The International Symposium on the Science of Engineering Ceramics  2016.5.11 

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  • 鉄錯体含有チタニアナノ粒子の創製

    片岡 卓也, 柴 弘太, 多賀谷 基博

    日本セラミックス協会 第2回ナノバイオセラミックスによる細胞機能制御テクノロジー研究会  2016.3.28 

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  • 蛍光メソ多孔質シリカ/リン酸カルシウム複合粒子の創製

    王 立印, 片岡 卓也, 小林 幸平, 多賀谷 基博

    日本セラミックス協会 第2回ナノバイオセラミックスによる細胞機能制御テクノロジー研究会  2016.3.28 

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  • 界面活性剤ミセル存在下における発光性水酸アパタイトナノ結晶の合成と特性

    片岡 卓也, 柴 弘太, 多賀谷 基博

    第64回応用物理学関係連合講演会  2016.3.20 

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  • 真球状チタニア/鉄(III)アセチルアセトナート複合粒子の合成と光/磁気特性

    片岡 卓也, 柴 弘太, Mitsuhiro Okuda, Santiago Blanco-Canosa, 多賀谷 基博

    日本セラミックス協会 2016年年会  2016.3.14 

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  • 界面活性剤を用いた水酸アパタイト合成技術の開発

    片岡 卓也, 本塚 智, 柴 弘太, 大沼 清, 大塚 雄市, 許 哲峰, 多賀谷 基博

    公益社団法人日本セラミックス協会 第1回ナノバイオセラミックスによる細胞機能制御テクノロジー研究会  2015.8.21 

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  • 陽イオン界面活性剤ミセルによる水酸アパタイトの核形成/成長制御とDV-Xα計算による界面相互作用解析

    片岡 卓也, 柴 弘太, 本塚 智, 小川 展弘, 山口 正, 大沼 清, 大塚 雄市, 許 哲峰, 多賀谷 基博

    第28回DV-Xα研究会  2015.8.5 

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Industrial property rights

  • ケイ酸塩系基材と希土類化合物との複合体、発光ナノ粒子、細胞の検出方法、動物の治療方法、医療装置、及びケイ酸塩系基材と希土類化合物との複合体の製造方法

    茶谷 直, 犬井 正彦, 多賀谷 基博, 片岡 卓也, 本塚 智

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    Applicant:株式会社オハラ

    Application no:特願2020-046605  Date applied:2020.3.17

    Announcement no:特開2021-147255  Date announced:2021.9.27

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  • ユーロピウム化合物の結晶体及びユーロピウム化合物の結晶体の製造方法

    茶谷 直, 犬井 正彦, 多賀谷 基博, 片岡 卓也, 本塚 智

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    Applicant:株式会社オハラ

    Application no:特願2020-046604  Date applied:2020.3.17

    Announcement no:特開2021-147254  Date announced:2021.9.27

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Awards

  • 科学技術賞

    2023.7   公益財団法人 岡山工学振興会   骨芽細胞の迅速な活性化を実現する有機/無機複合粒子の開発

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  • 学術奨励賞

    2022.5   山陽放送学術文化・スポーツ振興財団   迅速な骨再生を誘起するキトサン/アパタイト複合ナノ粒子の合成と表面構造の制御

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  • 第33回秋季シンポジウム 優秀発表賞

    2020.9   日本セラミックス協会   特定細胞の標識能と増殖抑制能を両立する水酸アパタイトナノ粒子の創製

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  • 優秀ポスター発表賞

    2019.3   日本セラミックス協会 2019年年会   メチレンブルー担持ナノポーラスチタニア粒子への光照射に伴う一重項酸素生成能の評価

    池田 遼太, 山田 伊織, 永田 真也, 片岡 卓也, 角田 正也, 多賀谷 基博

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  • 優秀発表賞

    2018.11   日本セラミックス協会 第22回生体関連セラミックス討論会   水酸アパタイト/Eu錯体複合粒子への葉酸誘導体固定と細胞標識機能化

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  • 第31回DV-Xα研究会 優秀発表賞

    2018.8   DV-Xα研究協会   カチオン性界面活性剤と水酸アパタイトの界面相互作用評価とユウロピウム(III)含有発光ナノ材料への展開

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  • 第二十六回無機リン化学討論会 第十四回若手優秀研究発表賞

    2017.8   日本無機リン化学会   水酸アパタイト/有機ユウロピウム(Ⅲ)錯体の複合構造構築と物性評価

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  • プレゼンテーション賞

    2016.12   日本セラミックス協会 第3回ナノバイオセラミックスによる細胞機能制御テクノロジー研究会   有機Eu錯体とリン酸カルシウムのハイブリッド化技術の開発

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  • 第23回材料科学若手研究者討論会 プレゼンテーション賞

    2016.8   日本材料科学会   陽イオン界面活性剤を活用した発光性水酸アパタイトナノ材料の創製

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Research Projects

  • 骨欠損部での速やかな骨再生の実現に向けた有機/無機複合ナノ粒子の創製

    Grant number:0351029-A  2023.04 - 2024.03

    池谷科学技術振興財団研究助成 

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    Authorship:Principal investigator 

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  • 骨芽細胞の迅速な活性化を実現する有機/無機複合粒子の開発

    2023

    公益財団法人 岡山工学振興会 

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  • Synthesis of chitosan/apatite nanohybrids for rapid bone regeneration

    Grant number:22K14502  2022.04 - 2025.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists  Grant-in-Aid for Early-Career Scientists

    片岡 卓也

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    Authorship:Principal investigator 

    Grant amount:\4550000 ( Direct expense: \3500000 、 Indirect expense:\1050000 )

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  • 迅速な骨再生を誘起するキトサン/アパタイト複合ナノ粒子の合成と表面構造の制御

    2022.04 - 2023.12

    山陽放送学術文化・スポーツ振興財団研究助成 

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  • 早期骨再生を促進するキトサン含有ハイドロキシアパタイトナノ粒子の創製とその表面特性の制御

    2021.12 - 2023.03

    公益財団法人大倉和親記念財団研究助成 

    片岡 卓也

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  • Synthesis of chlorophyll molecule-containing apatite nanocrystals realizing super early cancer diagnosis and treatment

    Grant number:18J20271  2018.04 - 2021.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for JSPS Fellows  Grant-in-Aid for JSPS Fellows

    片岡 卓也

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    Grant amount:\2200000 ( Direct expense: \2200000 )

    特定細胞を安全に可視化するナノ材料開発において,生体親和性に加えて発光強度と水分散性の向上が課題である.我々のグループでは,昨年度,内部・無機相と表面・有機相との相互作用によって発光過程を制御できると考え,Eu (III) イオンを含有した水酸アパタイト (HA) とクエン酸分子の複合粒子を合成し,クエン酸の複合化に伴う粒子の無機/有機界面相互作用による発光特性と水分散性への影響について研究した.有機相として使用したクエン酸はがん細胞のみを選択的に増殖抑制し,正常細胞には影響がない.蛍光プローブとして,HAに含有させたEu (III) イオンがクエン酸存在下においてどのような物性を示すかを観測した.本年度は,実際にEu (III) イオン含有HAとクエン酸分子の複合粒子のがん細胞に対する標識能及び増殖抑制能について研究した.
    本複合粒子を細胞培養時に添加し,がん細胞への影響を評価した結果,複合粒子は細胞と反応して,細胞からの赤色発光を示しながら細胞の増殖を抑制し,細胞標識と細胞増殖抑制の二機能を示した.更に葉酸によって複合粒子の表面を修飾すると,細胞への取り込み効率が高まり細胞増殖をさらに抑制できることが判明した.複合したクエン酸分子は,腫瘍化したがん細胞の成長抑制にも大きく寄与する可能性が示唆された.特に,60時間の培養によって腫瘍化したがん細胞と効果的に複合粒子は反応し,複合粒子添加後1時間で細胞形状に沿った細胞標識を達成でき,細胞増殖抑制と迅速な標識が同時に達成された.
    現在,マイクロリアクターによる核形成と粒成長過程を分離した新規合成技術によって均一粒子形状をもったHA単相の合成に成功した.さらに,一重項励起酸素生成可能な色素 (メチレンブルーなど) の複合技術も確立している.次年度において,「細胞の診断と治療の両立」を達成できる見込みである.

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Class subject in charge

  • Advanced Internship for Interdisciplinary Medical Sciences and Engineering (2023academic year) Year-round  - その他

  • Technical English for Interdisciplinary Medical Sciences and Engineering (2023academic year) Late  - その他

  • Research Works for Interdisciplinary Medical Sciences and Engineering (2023academic year) Year-round  - その他

  • Research Works for Interdisciplinary Medical Sciences and Engineering (2023academic year) Year-round  - その他

  • Synthetic Chemistry Experiment 2 (2023academic year) 1st semester  - 月5~8,木5~8

  • Applied Chemistry Experiment 1 (2023academic year) 1st semester  - 月5~8,木5~8

  • Material Process Experiment 2 (2023academic year) 1st semester  - 月5~8,木5~8

  • Technical English for Interdisciplinary Medical Sciences and Engineering (2022academic year) Late  - その他

  • Research Works for Interdisciplinary Medical Sciences and Engineering (2022academic year) Year-round  - その他

  • Material Process Experiment 3 (2022academic year) Third semester  - 火5~8,金5~8

  • Material Process Experiment 3 (2022academic year) Third semester  - 火5~8,金5~8

  • 材料プロセス実験3 (2021academic year) 第3学期  - 火5,火6,火7,火8,金5,金6,金7,金8

  • 材料プロセス実験3 (2021academic year) 第3学期  - 火5,火6,火7,火8,金5,金6,金7,金8

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Social Activities

  • 無機/有機界面での相互作用に基づく機能性バイオセラミックスの創製

    Role(s):Lecturer

    第14回「セラミックスの基礎学問研修会」, 日本セラミックス協会中国四国支部  2023.11.9

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    Type:Seminar, workshop

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