Updated on 2025/11/30

写真a

 
MURAI Aya
 
Organization
Scheduled update Assistant Professor
Position
Assistant Professor
External link

Degree

  • 医学博士 ( 2017.3 )

  • 博士（医学） ( 岡山大学 )

Research Interests

  • 鼻科学

 

Papers

  • A randomized, double-blind, within-person trial of hot saline at 42 °C for endoscopic sinus surgery. International journal

    Aiko Shimizu, Seiichiro Makihara, Kensuke Uraguchi, Aya Murai, Toshiharu Mitsuhashi, Shin Kariya, Mizuo Ando

    Acta oto-laryngologica   1 - 8   2025.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: The efficacy and safety of 42 °C hot saline irrigation in haemostasis remain unclear. AIMS/OBJECTIVES: This study aimed to investigate the effects of hot saline irrigation at 42 °C during endoscopic sinus surgery (ESS) to assess its efficacy in reducing intraoperative bleeding. MATERIAL AND METHODS: In this randomized, double-blind, within-person trial, 13 patients with bilateral chronic rhinosinusitis with nasal polyps undergoing ESS were randomly assigned to receive 42 °C hot saline irrigation on one side and room-temperature saline irrigation as a control on the contralateral side. The primary outcome was the Boezaart surgical field score, while secondary outcomes included operative time, histopathological changes, and postoperative complications. The Wilcoxon signed-rank test was used for statistical analyses. RESULTS: The Boezaart surgical field score significantly improved with hot saline irrigation compared with the control during anterior ethmoid surgery (p = 0.046); however, no significant difference was observed during posterior ethmoid and sphenoid surgeries. Operative times were comparable between groups. No adverse tissue changes or postoperative complications were observed. CONCLUSIONS AND SIGNIFICANCE: Hot saline irrigation at 42 °C improved surgical field visibility during ESS without adverse effects, demonstrating its potential as a haemostatic adjunct. This cost-effective and safe technique warrants further investigation for broader clinical application. TRIAL REGISTRATION: UMIN Clinical Trials Registry: UMIN000052864.

    DOI： 10.1080/00016489.2025.2574505

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  • The Intranasal Administration of Semaphorin 3A Inhibitor in a Mouse Model of Olfactory Disorder. International journal

    Aya Murai, Minori Noda, Aiko Shimizu, Junko Takahara, Seiichiro Makihara, Mizuo Ando

    Cureus   17 ( 9 )   e92587   2025.9

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    This study investigated the effects of intranasal administration of a semaphorin 3A inhibitor (Sema3A-I) in a mouse model of olfactory disorder, where olfactory sensory neuron (OSN) axons had been severely damaged. We performed axotomy (transection of OSN axons) of the OSNs in mice and administered Sema3A‑I intranasally to seven mice and saline to another seven mice. Following treatment, we assessed the thickness of the olfactory epithelium and the regeneration ratio of OSN axons. Intranasal administration of Sema3A-I did not significantly promote OSN regeneration, axonal outgrowth, or improve axonal projection compared to saline administration. Although Sema3A-I administration showed some promotion of axonal outgrowth, the difference was not statistically significant. Continuous subcutaneous administration of Sema3A-I in rats after axotomy promotes OSN regeneration and axonal outgrowth. Given that intranasal administration is minimally invasive, we believe that it may still be a feasible route when combined with additional treatment strategies. Further investigation into administration methods and therapeutic combinations is warranted.

    DOI： 10.7759/cureus.92587

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  • Anterior Uveitis Secondary to an Infected Postoperative Maxillary Cyst.

    Yuta Imamura, Yusuke Shiode, Shuhei Kimura, Mio Hosokawa, Ryo Matoba, Yuki Kanzaki, Hiroya Kindo, Tetsuro Morita, Aya Murai, Mizuo Ando, Yuki Morizane

    Acta medica Okayama   79 ( 4 )   283 - 286   2025.8

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    A 76-year-old man presented with right eyelid swelling and deteriorated vision. Examination revealed anterior uveitis with hypopyon and a visual acuity of 20/2,000 in the right eye, with no abnormalities in the left. Computed tomography revealed enlargement of the right maxillary sinus and internal fluid accumulation, suggesting a postoperative maxillary cyst (POMC). Nasal endoscopic surgery drained the pus by opening the lower wall of the maxillary cyst. Following the procedure, intraocular inflammation resolved, and visual acuity in the right eye improved to 24/20. This is the first reported case of uveitis secondary to POMC.

    DOI： 10.18926/AMO/69154

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  • Endoscopic surgical strategy for highly vascular pediatric sinonasal and pterygopalatine fossa tumors. International journal

    Aiko Shimizu, Seiichiro Makihara, Minori Noda, Aya Murai, Mizuo Ando

    Auris, nasus, larynx   52 ( 3 )   243 - 247   2025.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    Pediatric sinonasal tumors are rare, and minimally invasive approaches are preferred because of unknown long-term effects on development. We report three cases of highly vascular pediatric sinonasal and pterygopalatine fossa tumors that were successfully removed using an endonasal endoscopic approach with transcatheter arterial embolization (TAE). The patients (9-11 years old) had contrast-enhanced tumors in the left ethmoid sinus near the sphenopalatine foramen in case 1, in the right nasal cavity near the sphenopalatine foramen in case 2, and in the right pterygopalatine fossa in case 3, with diameters of 32, 50, and 61 mm, respectively. Computed tomography and magnetic resonance imaging demonstrated tumors with strong contrast enhancement and flow voids in all cases. TAE was performed in all cases on the day of surgery, followed by endoscopic sinus surgery with nasal septal modification. Pathology revealed pyogenic granuloma, nasal polyps, and juvenile angiofibroma. After TAE, tumor reduction improved visualization in case 1. Nasal septum manipulation enabled medial traction and tumor base identification in cases 2 and 3. The combination of preoperative TAE and septal modification proved effective for achieving complete endoscopic tumor removal. No complications occurred, and follow-up at 1-1.5 years showed no tumor recurrence or developmental abnormalities.

    DOI： 10.1016/j.anl.2025.04.006

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  • Combined simultaneous endoscopic endonasal and transcranial surgery using high-definition three-dimensional exoscope for malignant tumors of the anterior skull base. Reviewed International journal

    Seiichiro Makihara, Yoshihiro Otani, Kensuke Uraguchi, Aiko Shimizu, Aya Murai, Takaya Higaki, Naoki Akisada, Shohei Fujimoto, Takuma Makino, Joji Ishida, Kentaro Fujii, Takao Yasuhara, Tomoyuki Ota, Hiroshi Matsumoto, Mizuo Ando

    Head & neck   46 ( 5 )   1074 - 1082   2024.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Advanced surgical interventions are required to treat malignancies in the anterior skull base (ASB). This study investigates the utility of endoscopic endonasal and transcranial surgery (EETS) using a high-definition three-dimensional exoscope as an alternative to traditional microscopy. METHODS: Six patients with carcinomas of varying histopathologies underwent surgery employing the EETS maneuver, which synchronized three distinct surgical modalities: harvesting of the anterolateral thigh flap, initiation of the transnasal technique, and initiation of the transcranial procedure. RESULTS: The innovative strategy enabled successful tumor resection and skull base reconstruction without postoperative local neoplastic recurrence, cerebrospinal fluid leakage, or neurological deficits. CONCLUSION: The integration of the exoscope and EETS is a novel therapeutic approach for ASB malignancies. This strategy demonstrates the potential of the exoscope in augmenting surgical visualization, enhancing ergonomics, and achieving seamless alignment of multiple surgical interventions. This technique represents a progressive shift in the management of these complex oncological challenges.

    DOI： 10.1002/hed.27724

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  • Risk Factors for Anterior Skull Base Injury in Endoscopic Sinus Surgery International journal

    Seiichiro Makihara, Kensuke Uraguchi, Tomoyuki Naito, Aiko Shimizu, Aya Murai, Takaya Higaki, Yohei Noda, Shin Kariya, Mitsuhiro Okano, Mizuo Ando

    Cureus   15 ( 11 )   e49273   2023.11

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Objectives This retrospective study aimed to investigate the relationships between the Keros classification, the Gera classification, the vertical height of the posterior ethmoid roof (ER), and anterior ethmoidal artery (AEA) types in Japanese patients. Methods We investigated the computed tomography (CT) slices of paranasal sinuses (120 sides) of 60 patients; measured the cribriform plate (CP) depth, lateral lamella CP angle (LLCPA), and vertical height of the lateral ER from the hard palate (LERHP) at the coronal plane of the posterior ethmoidal artery (PEA); and reviewed the AEA types, whether floating or non-floating. Results CP depth was positively correlated with LLCPA (r=0.63; p<0.01) and the height of LERHP (r=0.19; p<0.05). The height of the LERHP in females was significantly lower than that in males. With increased CP depth, floating AEAs became prevalent (p<0.001). Conclusion In females, low height of the posterior ethmoid sinus roof, where cerebrospinal fluid (CSF) leaks occurred while penetrating the basal lamella, often existed; the heights positively correlated with the Keros classification in Japanese patients. The Keros and Gera classifications, AEA type, and posterior ER height do not individually constitute a complete risk assessment but may correlate, preventing major complications, such as CSF leak and orbital hemorrhage.

    DOI： 10.7759/cureus.49273

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  • 嗅覚障害モデルマウスに対する嗅素別嗅覚刺激療法の検討

    村井 綾, 清水 藍子, 牧原 靖一郎, 檜垣 貴哉, 安藤 瑞生

    日本鼻科学会会誌   62 ( 3 )   494 - 494   2023.9

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    Language：Japanese   Publisher：(一社)日本鼻科学会  

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  • 寄生型副鼻腔真菌症患者の呼吸機能に関する検討

    牧原 靖一郎, 假谷 伸, 大道 亮太郎, 浦口 健介, 清水 藍子, 村井 綾, 檜垣 貴哉, 岡野 光博, 安藤 瑞生

    日本鼻科学会会誌   62 ( 3 )   524 - 524   2023.9

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  • 小児上顎洞血瘤腫の1例

    増井 貴嗣, 檜垣 貴哉, 牧原 靖一郎, 村井 綾, 清水 藍子, 安藤 瑞生

    日本鼻科学会会誌   62 ( 3 )   522 - 522   2023.9

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  • 当科におけるDupilumab使用の現状

    檜垣 貴哉, 増井 貴嗣, 清水 藍子, 村井 綾, 牧原 靖一郎, 安藤 瑞生

    日本鼻科学会会誌   62 ( 3 )   530 - 530   2023.9

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  • 慢性副鼻腔炎患者における血清1,25-dihydroxyvitamin D値の検討

    牧原 靖一郎, 假谷 伸, 清水 藍子, 村井 綾, 檜垣 貴哉, 岡野 光博, 安藤 瑞生

    日本耳鼻咽喉科頭頸部外科学会会報   126 ( 4 )   646 - 646   2023.4

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    Language：Japanese   Publisher：(一社)日本耳鼻咽喉科頭頸部外科学会  

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  • 嗅覚障害モデルマウスに対するSemaphorin3A阻害薬点鼻投与の検討

    村井 綾, 清水 藍子, 牧原 靖一郎, 檜垣 貴哉, 假谷 伸, 安藤 瑞生

    日本鼻科学会会誌   61 ( 3 )   545 - 545   2022.10

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    Language：Japanese   Publisher：(一社)日本鼻科学会  

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  • 好酸球性副鼻腔炎における好酸球性多発血管炎性肉芽腫症発症のリスク因子についての検討

    檜垣 貴哉, 村井 綾, 清水 藍子, 牧原 靖一郎, 假谷 伸, 安藤 瑞生

    日本鼻科学会会誌   61 ( 3 )   519 - 519   2022.10

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  • 水中下での後鼻神経中枢切断と末梢枝切断との術後症状スコアの比較

    牧原 靖一郎, 清水 藍子, 村井 綾, 檜垣 貴哉, 假谷 伸, 岡野 光博, 安藤 瑞生

    日本鼻科学会会誌   61 ( 3 )   454 - 454   2022.10

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  • The add-on effect of an intranasal antihistamine with an intranasal corticosteroid in Japanese cedar pollinosis. International journal

    Takenori Haruna, Shin Kariya, Takaya Higaki, Aya Murai, Kengo Kanai, Aiko Oka, Maki Akamatsu, Mizuo Ando, Kazunori Nishizaki, Mitsuhiro Okano

    Auris, nasus, larynx   50 ( 1 )   81 - 86   2022.6

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    OBJECTIVE: Combination intranasal drugs with a corticosteroid and antihistamine are available in several countries with better effect than treatments with single agents. However, it remains unclear whether this effect is also seen in Japanese cedar pollinosis (JCP), the most prevalent seasonal allergic rhinitis in Japan. We investigated the effect of an add-on intranasal antihistamine with an intranasal corticosteroid in JCP during the pollen dispersal period. (UMIN000025508) METHODS: We performed a double-blinded, randomized, placebo-controlled trial from March 1 to 14, 2017. Patients (n = 20 per group) received either a mometasone furoate nasal spray (MFNS) plus a levocabastine nasal spray (levocabastine group) or MFNS plus a placebo nasal spray (placebo group). The primary endpoint was the difference in the total nasal symptom score (TNSS) after treatment between the two groups. Differences in the total ocular symptom score, total symptom score, total medication score, total symptom-medication score, and five individual symptoms as well as safety were the secondary endpoints. RESULTS: The change in the TNSS from baseline was significantly greater in the levocabastine group than in the placebo group. A significant reduction in the TNSS was observed more than 6 days earlier in the levocabastine group than in the placebo group. Such add-on effects were also seen in the secondary endpoints. Both treatments were well-tolerated. CONCLUSION: The intranasal antihistamine provided better control of not only nasal symptoms, but also of ocular symptoms, and decreased the need for rescue medications when added to intranasal corticosteroid treatment in JCP patients.

    DOI： 10.1016/j.anl.2022.05.007

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  • 中鼻甲介蜂巣が出血点となった鼻出血の1例

    檜垣 貴哉, 清水 藍子, 浦口 健介, 大道 亮太郎, 村井 綾, 假谷 伸, 安藤 瑞生

    日本鼻科学会会誌   60 ( 3 )   413 - 413   2021.9

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  • 好酸球性副鼻腔炎・中耳炎(生物学的製剤) 好酸球増多によるDupilumab投与中断後に投与再開しえた好酸球性副鼻腔炎・中耳炎の1例

    檜垣 貴哉, 宮原 信明, 清水 藍子, 村井 綾, 安藤 瑞生

    アレルギー   70 ( 6-7 )   820 - 820   2021.8

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  • マウスアレルギー性鼻炎モデルにおけるMinimal Persistent Inflammationの検討 Invited Reviewed

    檜垣貴哉, 村井 綾, 假谷 伸

    アレルギーの臨床   40 ( 9 )   753 - 754   2020

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：(株)北隆館  

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  • 生体腎移植後に急性浸潤性の再燃を呈した副鼻腔真菌症の1例

    西村 慎吾, 和田 耕一郎, 小林 泰之, 渡邉 豊彦, 村井 綾, 檜垣 貴哉, 那須 保友, 荒木 元朗, 関戸 崇了, 吉永 香澄, 和田里 章悟, 丸山 雄樹, 光井 洋介, 窪田 理沙, 山下 美里

    移植   55   387_3 - 387_3   2020

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    Language：Japanese   Publisher：一般社団法人 日本移植学会  

    <p>症例は65歳男性。糖尿病性腎症による末期腎不全に対する腎移植術前CTにて右蝶形骨洞に真菌を疑う軟部影を認めたが、無症候性であった。しかしながら、移植後の免疫抑制状態で劇症型になる可能性を考慮し、移植3カ月前に内視鏡下副鼻腔手術ESSにて糸状菌塊を除去（粘膜への真菌浸潤なし）、追加治療することなく経過は安定していた。 生体腎移植については妻をドナーとしたABO不適合（術前減感作療法としてRituximab 200mg/body×1、DFPP×2、PE×1を実施、免疫抑制剤はTac-ER、MMF、PSL、Basiliximabを使用）、経過は良好でPOD18に退院となった（ Cr 1.28mg/dl ）。 移植後2カ月が経過し、右顔面痛・頭痛が出現、近医で副鼻腔洗浄や抗菌薬投与を受けるも改善せず。β-Dグルカン 53pg/mlと異常高値、副鼻腔MRIでは一部骨への浸潤を疑う軟部影を認め、再度ESSを施行、紙様板は腐骨化を認めたが真菌塊を可及的に除去した。VRCZも併用・継続し、術後1カ月でβ-Dグルカンも正常化、現在、再燃を認めていない。 浸潤性副鼻腔真菌症は副鼻腔から眼窩，海綿状静脈洞，頭蓋内へ浸潤し致死的となり、全生存率は概ね50%と、予後不良とされる。今回、予防的にESSを先行したが、腎移植後、急性浸潤性に再燃した症例を経験したので、若干の文献的考察を加えて報告する。 </p>

    DOI： 10.11386/jst.55.Supplement_387_3

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  • Distorted Coarse Axon Targeting and Reduced Dendrite Connectivity Underlie Dysosmia after Olfactory Axon Injury International journal

    Aya Murai, Ryo Iwata, Satoshi Fujimoto, Shuhei Aihara, Akio Tsuboi, Yuko Muroyama, Tetsuichiro Saito, Kazunori Nishizaki, Takeshi Imai

    eneuro   3 ( 5 )   ENEURO.0242 - 16.2016   2016.9

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Society for Neuroscience  

    The glomerular map in the olfactory bulb (OB) is the basis for odor recognition. Once established during development, the glomerular map is stably maintained throughout the life of an animal despite the continuous turnover of olfactory sensory neurons (OSNs). However, traumatic damage to OSN axons in the adult often leads to dysosmia, a qualitative and quantitative change in olfaction in humans. A mouse model of dysosmia has previously indicated that there is an altered glomerular map in the OB after the OSN axon injury; however, the underlying mechanisms that cause the map distortion remain unknown. In this study, we examined how the glomerular map is disturbed and how the odor information processing in the OB is affected in the dysosmia model mice. We found that the anterior-posterior coarse targeting of OSN axons is disrupted after OSN axon injury, while the local axon sorting mechanisms remained. We also found that the connectivity of mitral/tufted cell dendrites is reduced after injury, leading to attenuated odor responses in mitral/tufted cells. These results suggest that existing OSN axons are an essential scaffold for maintaining the integrity of the olfactory circuit, both OSN axons and mitral/tufted cell dendrites, in the adult.

    DOI： 10.1523/eneuro.0242-16.2016

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  • Determining minimal clinically important differences in Japanese cedar/cypress pollinosis patients. International journal

    Takaya Higaki, Mitsuhiro Okano, Shin Kariya, Tazuko Fujiwara, Takenori Haruna, Haruka Hirai, Aya Murai, Minoru Gotoh, Kimihiro Okubo, Shuji Yonekura, Yoshitaka Okamoto, Kazunori Nishizaki

    Allergology international : official journal of the Japanese Society of Allergology   62 ( 4 )   487 - 93   2013.12

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    BACKGROUND: Statistically significant results of medical intervention trials are not always clinically meaningful. We sought to estimate the minimal clinically important difference (MCID) (the smallest change in a given endpoint that is meaningful to a patient) during seasonal alteration of Japanese cedar/cypress pollinosis (JCCP). METHODS: Results of a double-blinded, placebo-controlled trial of JCCP patients conducted between 2008 and 2010 were analyzed using an anchor-based method in which a face scale for Japanese rhinoconjunctivitis quality-of-life questionnaire (JRQLQ) was set as an anchor. MICDs were calculated as changes of average scores, including those for naso-ocular symptoms with 5 items in diary cards (T5SS), naso-ocular symptoms with 6 items (T6SS) and QOL with 17 items on the JRQLQ when face scale scores either improved or deteriorated by one point. RESULTS: In 2009 and 2010, 3,698 and 374, respectively, grains/cm(2) of pollens were dispersed. The MCIDs for T5SS in 2009 and 2010 were 1.426 (0.285 per item) and 1.441 (0.288), respectively. The MCIDs for T6SS were 4.115 (0.686) and 3.183 (0.531) in 2009 and 2010, respectively. The MCIDs for QOL were 10.469 (0.616) and 6.026 (0.354) in 2009 and 2010, respectively. CONCLUSIONS: For T5SS in the diary, T6SS and QOL in JRQLQ, unit differences of 1.5 (0.3 per item), 3.6 (0.6) and 8.2 (0.5), respectively, were considered clinically meaningful by JCCP patients. The MCID for symptoms recorded in the diary was stable irrespective of the dispersed pollen level.

    DOI： 10.2332/allergolint.13-OA-0570

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  • The facial nerve canal in patients with Bell's palsy: an investigation by high-resolution computed tomography with multiplanar reconstruction. International journal

    Aya Murai, Shin Kariya, Kouzou Tamura, Akira Doi, Kenichi Kozakura, Mitsuhiro Okano, Kazunori Nishizaki

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery   270 ( 7 )   2035 - 8   2013.7

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    Facial nerve edema is an important finding in Bell's palsy patients. Inflammation may cause facial nerve edema, and mechanical compression and ischemic change of the facial nerve may occur in the facial nerve canal. A few studies have reported the dimensions of the facial nerve canal using conventional computed tomography or human temporal bone sections. However, the cross-sectional area of the facial nerve canal has not been fully understood. Therefore, the cross-sectional area of the facial nerve canal was measured in patients with unilateral Bell's palsy by computer tomography with multiplanar reconstruction. Sixteen patients with unilateral Bell's palsy were enrolled. Computed tomography of the temporal bone was performed, and perpendicular images to the facial nerve canal were reconstructed by the multiplanar reconstruction technique. The cross-sectional area of the facial nerve canal on the affected and unaffected sides was measured at the labyrinthine segment, the horizontal segment, and the mastoid segment. Both in the labyrinthine and horizontal segments, the mean cross-sectional area of the facial nerve canal was significantly smaller on the affected side than on the unaffected side. There was no significant difference between the affected and unaffected sides in the cross-sectional area of the facial nerve canal in the mastoid segment. The labyrinthine segment was the narrowest segment in the facial nerve canal. These findings suggest that the facial nerve is vulnerable, especially in the labyrinthine segment of the facial nerve canal, and a narrow facial nerve canal may be one of the risk factors for Bell's palsy.

    DOI： 10.1007/s00405-012-2253-7

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  • Transcatheter arterial embolisation for paediatric inflammatory pseudotumour of the maxillary sinus Reviewed

    Aya Murai, Kenji Sugiu, Shin Kariya, Kazunori Nishizaki

    JOURNAL OF LARYNGOLOGY AND OTOLOGY   125 ( 11 )   1189 - 1192   2011.11

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    DOI： 10.1017/S0022215111001848

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  • 206 マンノース結合レクチンのスギ花粉症における役割(自然免疫, 第55回日本アレルギー学会秋季学術大会)

    岡野 光博, 前田 恵, 村井 綾, 藤原 田鶴子, 木村 吉伸, 西崎 和則

    アレルギー   54 ( 8 )   1058 - 1058   2005

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    Language：Japanese   Publisher：一般社団法人 日本アレルギー学会  

    DOI： 10.15036/arerugi.54.1058_2

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  • Distorted coarse axon targeting and reduced dendrite connectivity underlie Dysosmia after olfactory axon injury

    Murai, A.| Iwata, R.| Fujimoto, S.| Aihara, S.| Tsuboi, A.| Muroyama, Y.| Saito, T.| Nishizaki, K.| Imai, T.

    2016

  • Determining minimal clinically important differences in Japanese cedar/cypress pollinosis patients

    Higaki, T.| Okano, M.| Kariya, S.| Fujiwara, T.| Haruna, T.| Hirai, H.| Murai, A.| Gotoh, M.| Okubo, K.| Yonekura, S.| Okamoto, Y.| Nishizaki, K.

    2013

  • The facial nerve canal in patients with Bell's palsy: An investigation by high-resolution computed tomography with multiplanar reconstruction

    Murai, A.| Kariya, S.| Tamura, K.| Doi, A.| Kozakura, K.| Okano, M.| Nishizaki, K.

    2013

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Books

  • 知っておきたい歯科における医療安全対策 : 大学病院での医科・歯科双方の視点から

    白井, 肇, 飯田, 征二, 前田, 嘉信, 塚原, 宏一, 窪木, 拓男

    デンタルダイヤモンド社  2025.10  （ ISBN:9784885106347 ）

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    Total pages：239p   Language：Japanese

    CiNii Books

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MISC

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Research Projects

  • 嗅細胞障害による異嗅症の分子学的治療戦略

    Grant number：20K18253  2020.04 - 2025.03

    日本学術振興会  科学研究費助成事業  若手研究

    村井 綾

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    Grant amount：\4290000 （ Direct expense: \3300000 、 Indirect expense：\990000 ）

    嗅覚受容体MOR29AとMOR29Bに蛍光標識した遺伝子組み換えマウス(MOR29ABマウス)に対し、嗅細胞の軸索を物理的に切断(軸索切断)を行い嗅覚障害モデルマウスを作成した。投射異常のおきた嗅細胞軸索は時間経過とともに軸索伸長の距離を伸ばし、本来の投射部位に近づいていく。そこで臨床的に効果の認められている嗅覚刺激療法をマウスに施行し、嗅細胞の回復を促進することが考えられた。しかしながら発生期に確立した嗅球の投射地図上のあるべき投射位置に戻るのは完全には困難である。そこで今軸索伸長を阻害する神経忌避因子Semaphorin3Aに着目した。Semaphorin3Aは発生期に受容体であるNeuropirin1と共同し、嗅細胞軸索の投射地図を形成するのに重要な役割を果たすが、発生期の終了とともにSemaphorin3Aは消失する。しかし、外傷をはじめとする炎症が引き起こされるとSemaphorin3Aは再度放出され、神経再生を阻害する。Semaphorin3A阻害薬を用いて、再生を阻害する炎症因子を取り除き、嗅覚再生にどのような影響を及ぼすか検討を行った。軸索切断後にSemaphorin3A阻害薬を3週間点鼻投与し、嗅細胞の再生、軸索伸長の過程を検討した。生理食塩水を同期間点鼻した対照群と比較して、嗅上皮の厚みは変わらなかった。Semaphorin3A阻害薬は軸索伸長を促進するが嗅細胞のターンオーバー促進にはつながらなかった。今後軸索投射の変化を経時的に検討を行う。

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  • Effect of olfactory training on synapse formation between regenerative olfactory neuron axons and glomeruli in the olfactory bulb

    Grant number：17K11360  2017.04 - 2021.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Nishizaki Kazunori

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    Grant amount：\4290000 （ Direct expense: \3300000 、 Indirect expense：\990000 ）

    We have been studying sensorineural hearing loss for many years, but correct olfactory function requires the restoration of olfactory maps in the olfactory bulb by regenerated olfactory sensory neurons (OSNs). Our previous report showed that after severe damage to OSN, such as axotomy, the olfactory map was distorted and synaptic connections between OSNs and secondary neurons were reduced. To normalize the olfactory map, we attempted sensory training in mice after axotomy. The sensory training group sniffed five odors, and the control mouse sniffed saline. The thickness of the olfactory epithelium makes a significant difference between the olfactory training group and the control group. We believed that olfactory training aids in the regeneration of OSN after axotomy, and that promoting OSN regeneration can normalize the distorted olfactory map of the olfactory bulb.

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  • Axon mistargeting and changes over time of olfactory sensory neurons with dysosmia model mouses.

    Grant number：17K16919  2017.04 - 2020.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    Murai Aya

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    Grant amount：\2860000 （ Direct expense: \2200000 、 Indirect expense：\660000 ）

    We research olfactory disorder and therapy using the mouse injured the olfactory nerve axon. The normal smell sense is required correct olfactory nerve network. But,the olfactory sensory neurons(OSN) damaged severely, the olfactory nerve formed incorrect network even the olfactory sensory neurons recover. We tried the several research, for example, the axons of OSN maintain for guidance of the new axon and administration of axon guidance. But these researches are not going well. So, we observe change over time of OSN axons in the olfactory bulb, the regenerated network is not perfect. But the OSN axons 19 weeks after injury are more promoted than 6 weeks.

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  • Investigation of the effectiveness of intranasal drug administration through the retrograde rostral migration pathway targeting neural stem cells

    Grant number：15K15619  2015.04 - 2018.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

    NISHIZAKI Kazunori

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    Grant amount：\3510000 （ Direct expense: \2700000 、 Indirect expense：\810000 ）

    To investigate the effectiveness of intranasal drug administration, the numbers of mitosis in the subventricular region where neural stem cells are present and of new neurons in the olfactory bulb where new neurons born in the subventricular region distribute through the rostral migration pathway were evaluated immunologically using Ki 67 (a marker of cell division) and DCX (a marker of new neurons), respectively.
    The nasal administration of prolactin or GDF (growth differentiation factor) 11 showed significant increases in cell division in the subventricular region and in neonatal neurons in the olfactory bulb by statistical analysis, respectively. However, as a transfer route of the nasal administration drug, the active evidence of direct transfer from the nasal cavity to brain tissue was not obtained.
    To elucidate brain tissue migration routes of intranasal medicine, further research such as analysis of the blood concentration of drug administered nasally should be necessary.

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Class subject in charge

  • Visio-auditory System （2025academic year） special  - その他

  • Practicals: Otolaryngology （2025academic year） special  - その他

  • Research Projects: Otolaryngology （2025academic year） special  - その他

  • Otorhinolaryngology (Core Clinical Practice) （2025academic year） special  - その他

  • Elective Clinical Practice (Otorhinolaryngology) （2025academic year） special  - その他