Post-complexation Functionalization of Cyclometalated Iridium(III) Complexes and Applications to Biomedical and Material Sciences Reviewed

Shin Aoki, Kenta Yokoi, Yosuke Hisamatsu, Chandrasekar Balachandran, Yuichi Tamura, Tomohiro Tanaka

Topics in Current Chemistry   380 ( 5 )   2022.10

Design, Synthesis and Biological Evaluation of Boron‐Containing Macrocyclic Polyamine Dimers and Their Zinc(II) Complexes for Boron Neutron Capture Therapy Reviewed

Hiroki Ueda, Minoru Suzuki, Yoshinori Sakurai, Tomohiro Tanaka, Shin Aoki

European Journal of Inorganic Chemistry   2022 ( 5 )   2022.2

The structure of POMGNT2 provides new insights into the mechanism to determine the functional O ‐mannosylation site on α‐dystroglycan Reviewed

Rieko Imae, Naoyuki Kuwabara, Hiroshi Manya, Tomohiro Tanaka, Masato Tsuyuguchi, Mamoru Mizuno, Tamao Endo, Ryuichi Kato

Genes to Cells   26 ( 7 )   485 - 494   2021.7

Design, Synthesis, and Biological Evaluation of Boron-Containing Macrocyclic Polyamines and Their Zinc(II) Complexes for Boron Neutron Capture Therapy Reviewed

Hiroki Ueda, Minoru Suzuki, Reiko Kuroda, Tomohiro Tanaka, Shin Aoki

Journal of Medicinal Chemistry   64 ( 12 )   8523 - 8544   2021.6

Mefloquine, a Potent Anti-severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Drug as an Entry Inhibitor in vitro Reviewed

Kaho Shionoya, Masako Yamasaki, Shoya Iwanami, Yusuke Ito, Shuetsu Fukushi, Hirofumi Ohashi, Wakana Saso, Tomohiro Tanaka, Shin Aoki, Kouji Kuramochi, Shingo Iwami, Yoshimasa Takahashi, Tadaki Suzuki, Masamichi Muramatsu, Makoto Takeda, Takaji Wakita, Koichi Watashi

Frontiers in Microbiology   12   2021.4

Potential anti-COVID-19 agents, cepharanthine and nelfinavir, and their usage for combination treatment Reviewed

Hirofumi Ohashi, Koichi Watashi, Wakana Saso, Kaho Shionoya, Shoya Iwanami, Takatsugu Hirokawa, Tsuyoshi Shirai, Shigehiko Kanaya, Yusuke Ito, Kwang Su Kim, Takao Nomura, Tateki Suzuki, Kazane Nishioka, Shuji Ando, Keisuke Ejima, Yoshiki Koizumi, Tomohiro Tanaka, Shin Aoki, Kouji Kuramochi, Tadaki Suzuki, Takao Hashiguchi, Katsumi Maenaka, Tetsuro Matano, Masamichi Muramatsu, Masayuki Saijo, Kazuyuki Aihara, Shingo Iwami, Makoto Takeda, Jane A. McKeating, Takaji Wakita

iScience   24 ( 4 )   102367 - 102367   2021.4

Development of metallosupramolecular phosphatases based on the combinatorial self-assembly of metal complexes and organic building blocks for the catalytic hydrolysis of phosphate monoesters Reviewed

Shin Aoki, Akib Bin Rahman, Yosuke Hisamatsu, Yuya Miyazawa, Mohd Zulkefeli, Yutaka Saga, Tomohiro Tanaka

Results in Chemistry   3   100133 - 100133   2021.1

Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy Reviewed

Naoyuki Kuwabara, Rieko Imae, Hiroshi Manya, Tomohiro Tanaka, Mamoru Mizuno, Hiroki Tsumoto, Motoi Kanagawa, Kazuhiro Kobayashi, Tatsushi Toda, Toshiya Senda, Tamao Endo, Ryuichi Kato

Nature Communications   11 ( 1 )   2020.1

Efficient synthesis of N- and O-linked glycopeptides using acid-labile Boc groups for the protection of carbohydrate moieties Reviewed

Tomohiro Tanaka, Mika Shiraishi, Akio Matsuda, Mamoru Mizuno

Tetrahedron Letters   60 ( 40 )   151106 - 151106   2019.10

Design, synthesis and biological evaluation of low molecular weight CXCR4 ligands. Reviewed

Sakyiamah MM, Kobayakawa T, Fujino M, Konno M, Narumi T, Tanaka T, Nomura W, Yamamoto N, Murakami T, Tamamura H

Bioorganic & medicinal chemistry   27 ( 6 )   1130 - 1138   2019.3

Design, synthesis and biological evaluation of low molecular weight CXCR4 ligands Reviewed

Sakyiamah MM, Kobayakawa T, Fujino M, KonnoM, Narumi T, Tanaka T, Nomura W, Yamamoto N, Murakami T, Tamamura H

ChemMedChem   8 ( 1 )   118 - 124   2019

Design and synthesis of boron containing monosaccharides by the hydroboration of d-glucal for use in boron neutron capture therapy (BNCT). Reviewed

Itoh T, Tamura K, Ueda H, Tanaka T, Sato K, Kuroda R, Aoki S

Bioorganic & medicinal chemistry   26 ( 22 )   5922 - 5933   2018.12

CDP-glycerol inhibits the synthesis of the functional O-mannosyl glycan of α-dystroglycan Reviewed

Rieko Imae, Hiroshi Manya, Hiroki Tsumoto, Kenji Osumi, Tomohiro Tanaka, Mamoru Mizuno, Motoi Kanagawa, Kazuhiro Kobayashi, Tatsushi Toda, Tamao Endo

Journal of Biological Chemistry   293 ( 31 )   12186 - 12198   2018.8

Bivalent 14-mer peptide ligands of CXCR4 with polyproline linkers with anti-chemotactic activity against Jurkat cells Reviewed

Tomohiro Tanaka, Toru Aoki, Wataru Nomura, Hirokazu Tamamura

JOURNAL OF PEPTIDE SCIENCE   23 ( 7-8 )   574 - 580   2017.7

Concise and Versatile Synthesis of Sulfoquinovosyl Acyl Glycerol Derivatives for Biological Applications Reviewed

Tomohiro Tanaka, Yasuhiro Sawamoto, Shin Aoki

CHEMICAL & PHARMACEUTICAL BULLETIN   65 ( 6 )   566 - 572   2017.6

B-11 NMR Probes of Copper(II): Finding and Implications of the Cu2+-Promoted Decomposition of ortho-Carborane Derivatives Reviewed

Tomohiro Tanaka, Yukiko Nishiura, Rikita Araki, Takaomi Saido, Ryo Abe, Shin Aoki

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY   ( 12 )   1819 - 1834   2016.4

Development of a fluoride-responsive amide bond cleavage device that is potentially applicable to a traceable linker Reviewed

Yamamoto, J, Maeda, N, Komiya, C, Tanaka, T, Denda, M, Ebisuno, K, Nomura, W, Tamamura, H, Sato, Y, Yamauchi, A, Shigenaga, A, Otaka, A

Tetrahedron   70   5122 - 5127   2014

Development of a traceable linker containing a thiol-responsive amino acid for the enrichment and selective labelling of target proteins Reviewed

Jun Yamamoto, Masaya Denda, Nami Maeda, Miku Kita, Chiaki Komiya, Tomohiro Tanaka, Wataru Nomura, Hirokazu Tamamura, Youichi Sato, Aiko Yamauchi, Akira Shigenaga, Akira Otaka

ORGANIC & BIOMOLECULAR CHEMISTRY   12 ( 23 )   3821 - 3826   2014

Cell-permeable stapled peptides based on HIV-1 integrase inhibitors derived from HIV-1 Gene products Reviewed

Wataru Nomura, Haruo Aikawa, Nami Ohashi, Emiko Urano, Mathieu Métifiot, Masayuki Fujino, Kasthuraiah Maddali, Taro Ozaki, Ami Nozue, Tetsuo Narumi, Chie Hashimoto, Tomohiro Tanaka, Yves Pommier, Naoki Yamamoto, Jun A. Komano, Tsutomu Murakami, Hirokazu Tamamura

ACS Chemical Biology   8 ( 10 )   2235 - 2244   2013.10

Expressed protein ligation at methionine: N-terminal attachment of homocysteine, ligation, and masking. Reviewed International journal

Tomohiro Tanaka, Anne M Wagner, John B Warner, Yanxin J Wang, E James Petersson

Angewandte Chemie (International ed. in English)   52 ( 24 )   6210 - 3   2013.6

Biological Effects of Bivalent-type CXCR4 Ligands with Rigid Linkers Reviewed

Nomura W, Tanaka T, Aoki T, Narumi T, Tamamura H

BIOPOLYMERS   100 ( 3 )   296 - 296   2013.5

腫瘍認識プローブ・HIV阻害剤としてのケモカイン受容体リガンド Reviewed

野村 渉, 田中 智博, 大橋 南美, 玉村 啓和

生体材料工学研究所年報   46   28 - 31   2013.3

Low-Molecular-Weight CXCR4 Ligands with Variable Spacers Reviewed

Tetsuo Narumi, Haruo Aikawa, Tomohiro Tanaka, Chie Hashimoto, Nami Ohashi, Wataru Nomura, Takuya Kobayakawa, Hikaru Takano, Yuki Hirota, Tsutomu Murakami, Naoki Yamamoto, Hirokazu Tamamura

ChemMedChem   8 ( 1 )   118 - 124   2013.1

Bivalent ligands for the chemokine receptor CXCR4 dimer and their function Reviewed

Nomura W, Tanaka T, Aikawa H, Narumi T, Tamamura H

JOURNAL OF PEPTIDE SCIENCE   18   S47 - S47   2012.9

HIV inhibitors targeting entry, fusion, and integrase Reviewed

Narumi Tetsuo, Tanaka Tomohiro, Nomura Wataru, Aikawa Haruo, Tamamura Hirokazu

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY   244   2012.8

Pharmacophore-based small molecule CXCR4 ligands Reviewed

Tetsuo Narumi, Tomohiro Tanaka, Chie Hashimoto, Wataru Nomura, Haruo Aikawa, Akira Sohma, Kyoko Itotani, Miyako Kawamata, Tsutomu Murakami, Naoki Yamamoto, Hirokazu Tamamura

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS   22 ( 12 )   4169 - 4172   2012.6

Conjugation of cell-penetrating peptides leads to identification of anti-HIV peptides from matrix proteins Reviewed

Tetsuo Narumi, Mao Komoriya, Chie Hashimoto, Honggui Wu, Wataru Nomura, Shintaro Suzuki, Tomohiro Tanaka, Joe Chiba, Naoki Yamamoto, Tsutomu Murakami, Hirokazu Tamamura

BIOORGANIC & MEDICINAL CHEMISTRY   20 ( 4 )   1468 - 1474   2012.2

A Synthetic C34 Trimer of HIV-1 gp41 Shows Significant Increase in Inhibition Potency Reviewed

Wataru Nomura, Chie Hashimoto, Aki Ohya, Kosuke Miyauchi, Emiko Urano, Tomohiro Tanaka, Tetsuo Narumi, Toru Nakahara, Jun A. Komano, Naoki Yamamoto, Hirokazu Tamamura

CHEMMEDCHEM   7 ( 2 )   205 - 208   2012.2

The successes and failures of HIV drug discovery Reviewed

Chie Hashimoto, Tomohiro Tanaka, Tetsuo Narumi, Wataru Nomura, Hirokazu Tamamura

EXPERT OPINION ON DRUG DISCOVERY   6 ( 10 )   1067 - 1090   2011.10

Azamacrocyclic Metal Complexes as CXCR4 Antagonists Reviewed

Tomohiro Tanaka, Tetsuo Narumi, Taro Ozaki, Akira Sohma, Nami Ohashi, Chie Hashimoto, Kyoko Itotani, Wataru Nomura, Tsutomu Murakami, Yamamoto B. Naoki, Hirokazu Tamamura

CHEMMEDCHEM   6 ( 5 )   834 - 839   2011.5

Design and Synthesis of Traceable Linker for Efficient Enrichment and Specific Labeling of Target Proteins Reviewed

Yamamoto Jun, Tanaka Tomohiro, Denda Masaya, Shigenaga Akira, Nomura Wataru, Tamamura Hirokazu, Otaka Akira

BIOPOLYMERS   96 ( 4 )   492   2011

Development of Bivalent Ligands for CXCR4 with Rigid Linkers and Application to Detection of Cancer Cells Reviewed

Nomura Wataru, Tomohiro Tanaka, Akemi Masuda, Tetsuo Narumi, Hirokazu Tamamura

BIOPOLYMERS   96 ( 4 )   510 - 511   2011

Synthesis and Application of Fluorescent-labeled Bivalent-type CXCR4 Ligands

Aikawa Haruo, Nomura Wataru, Narumi Tetsuo, Tanaka Tomohiro, Tamamura Hirokazu

Proceedings of the Symposium on Progress in Organic Reactions and Syntheses   37   109 - 109   2011

Bivalent Ligands of CXCR4 with Rigid Linkers for Elucidation of the Dimerization State in Cells Reviewed

Tomohiro Tanaka, Wataru Nomura, Tetsuo Narumi, Akemi Masuda, Hirokazu Tamamura

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   132 ( 45 )   15899 - 15901   2010.11

HIV-1遺伝子産物由来のインテグラーゼ阻害剤の創出 Reviewed

橋本 知恵, 田中 智博, 浦野 恵美子, 尾崎 太郎, 新井 啓之, 鳴海 哲夫, 野村 渉, Maddali Kasthuraiah, Pommier Yves, 山本 直樹, 駒野 淳, 玉村 啓和

日本エイズ学会誌   12 ( 4 )   370 - 370   2010.11

gp120のCD4結合サイトを模倣した新規抗原分子の創製 Reviewed

尾崎 太郎, 田中 智博, 宮内 浩典, 橋本 知恵, 鳴海 哲夫, 野村 渉, 山本 直樹, 駒野 淳, 玉村 啓和

日本エイズ学会誌   12 ( 4 )   484 - 484   2010.11

HIV-1侵入過程の動的超分子機構を基にした新規エイズワクチンの創製 Reviewed

橋本 知恵, 鳴海 哲夫, 野村 渉, 中原 徹, 田中 智博, 大庭 賢二, 相馬 晃, 長谷山 正樹, 村上 努, 山本 直樹, 玉村 啓和

日本エイズ学会誌   12 ( 4 )   483 - 483   2010.11

CD4 mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist Reviewed

Tetsuo Narumi, Chihiro Ochiai, Kazuhisa Yoshimura, Shigeyoshi Harada, Tomohiro Tanaka, Wataru Nomura, Hiroshi Arai, Taro Ozaki, Nami Ohashi, Shuzo Matsushita, Hirokazu Tamamura

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS   20 ( 19 )   5853 - 5858   2010.10

Peptidic HIV integrase inhibitors derived from HIV gene products: Structure-activity relationship studies Reviewed

Shintaro Suzuki, Kasthuraiah Maddali, Chie Hashimoto, Emiko Urano, Nami Ohashi, Tomohiro Tanaka, Taro Ozaki, Hiroshi Arai, Hiroshi Tsutsumi, Tetsuo Narumi, Wataru Nomura, Naoki Yamamoto, Yves Pommier, Jun A. Komano, Hirokazu Tamamura

BIOORGANIC & MEDICINAL CHEMISTRY   18 ( 18 )   6771 - 6775   2010.9

Peptide HIV-1 integrase inhibitors from HIV-1 gene products. Reviewed

Suzuki S, Urano E, Hashimoto C, Tsutsumi H, Nakahara T, Tanaka T, Nakanishi Y, Maddali K, Han Y, Hamatake M, Miyauchi K, Pommier Y, Beutler JA, Sugiura W, Fuji H, Hoshino T, Itotani K, Nomura W, Narumi T, Yamamoto N, Komano JA, Tamamura H

Journal of medicinal chemistry   53 ( 14 )   5356 - 5360   2010.7

Remodeling of Dynamic Structures of HIV-1 Envelope Proteins Leads to Synthetic Antigen Molecules Inducing Neutralizing Antibodies Reviewed

Toru Nakahara, Wataru Nomura, Kenji Ohba, Aki Ohya, Tomohiro Tanaka, Chie Hashimoto, Tetsuo Narumi, Tsutomu Murakami, Naoki Yamamoto, Hirokazu Tamamura

BIOCONJUGATE CHEMISTRY   21 ( 4 )   709 - 714   2010.4

合成抗原ペプチドによるHIV-1 gp41の三量体構造を認識する抗体の誘導 Reviewed

野村 渉, 中原 徹, 大矢 亜紀, 大庭 賢二, 田中 智博, 橋本 知恵, 鳴海 哲夫, 村上 努, 山本 直樹, 玉村 啓和

日本薬学会年会要旨集   130年会 ( 2 )   114 - 114   2010.3

エイズワクチンを指向した宿主受容体CXCR4由来抗原分子の創製 Reviewed

橋本 知恵, 野村 渉, 田中 智博, 中原 徹, 鳴海 哲夫, 大庭 賢二, 村上 努, 山本 直樹, 玉村 啓和

日本薬学会年会要旨集   130年会 ( 2 )   71 - 71   2010.3

CD4 mimics targeting the mechanism of HIV entry. Reviewed

Yamada Y, Ochiai C, Yoshimura K, Tanaka T, Ohashi N, Narumi T, Nomura W, Harada S, Matsushita S, Tamamura H

Bioorganic & medicinal chemistry letters   20 ( 1 )   354 - 358   2010.1

Beyond antibodyという研究領域 ペプチドミメティクを基盤とした阻害剤と新規概念によるワクチン Reviewed

玉村 啓和, 野村 渉, 鳴海 哲夫, 田中 智博, 駒野 淳, 山本 直樹

日本生化学会大会プログラム・講演要旨集   82回   1S4a - 4   2009.9

センシングバイオロジーを指向した蛍光性CXCR4プローブの創出とリガンドスクリーニング法の開発 Reviewed

堤 浩, 野村 渉, 田中 智博, 田部 泰章, 糸谷 恭子, 玉村 啓和

生体材料工学研究所年報   42   3 - 7   2009.3

Fluorogenically Active Leucine Zipper Peptides as Tag-Probe Pairs for Protein Imaging in Living Cells Reviewed

Hiroshi Tsutsumi, Wataru Nomura, Seiichiro Abe, Tomoaki Mino, Akemi Masuda, Nami Ohashi, Tomohiro Tanaka, Kenji Ohba, Naoki Yamamoto, Kazunari Akiyoshi, Hirokazu Tamamura

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   48 ( 48 )   9164 - 9166   2009

Development of chemokine receptor CXCR4 antagonists using bio-mimetic strategy. Reviewed

Tamamura H, Tanaka T, Tsutsumi H, Ohashi N, Hiramatsu K, Araki T, Ojida A, Hamachi I, Wang Z, Peiper SC, Trent JO, Ueda S, Oishi S, Fujii N

Advances in experimental medicine and biology   611   145 - 146   2009

Stereoselective synthesis of peptidomimetics based on acid-catalyzed ring-opening of beta-aziridinyl-alpha,beta-enoates. Reviewed

Tamamura H, Tanaka T, Tsutsumi H, Nemoto K, Mizokami S, Ohashi N, Oishi S, Fujii N

Advances in experimental medicine and biology   611   149 - 150   2009

Structure-activity relationship study on artificial CXCR4 ligands possessing the cyclic pentapeptide scaffold: the exploration of amino acid residues of pentapeptides by substitutions of several aromatic amino acids Reviewed

Tomohiro Tanaka, Wataru Nomura, Tetsuo Narumi, Ai Esaka, Shinya Oishi, Nami Ohashi, Kyoko Itotani, Barry J. Evans, Zi-xuan Wang, Stephen C. Peiper, Nobutaka Fujii, Hirokazu Tamamura

ORGANIC & BIOMOLECULAR CHEMISTRY   7 ( 18 )   3805 - 3809   2009

A future perspective on the development of chemokine receptor CXCR4 antagonists Reviewed

Hirokazu Tamamura, Hiroshi Tsutsumi, Wataru Nomura, Tomohiro Tanaka, Nobutaka Fujii

EXPERT OPINION ON DRUG DISCOVERY   3 ( 10 )   1155 - 1166   2008.10

Fluorophore labeling enables imaging and evaluation of specific CXCR4-ligand interaction at the cell membrane for fluorescence-based screening Reviewed

Wataru Nomura, Yasuaki Tanabe, Hiroshi Tsutsumi, Tomohiro Tanaka, Kenji Ohba, Naoki Yamamoto, Hirokazu Tamamura

BIOCONJUGATE CHEMISTRY   19 ( 9 )   1917 - 1920   2008.9

HIV侵入の動的超分子機構を標的としたCD4 mimic small moleculeの創製 Reviewed

山田 裕子, 吉村 和久, 田中 智博, 堤 浩, 野村 渉, 糸谷 恭子, 増野 弘幸, 柴田 潤二, 畑田 万紀子, 松下 修三, 玉村 啓和

日本薬学会年会要旨集   128年会 ( 2 )   84 - 84   2008.3

Structure-activity relationship study of CXCR4 antagonists bearing the cyclic pentapeptide scaffold: identification of the new pharmacophore Reviewed

Tomohiro Tanaka, Hiroshi Tsutsumi, Wataru Nomura, Yasuaki Tanabe, Nami Ohashi, Ai Esaka, Chihiro Ochiai, Jun Sato, Kyoko Itotani, Tsutomu Murakami, Kenji Ohba, Naoki Yamamoto, Nobutaka Fujii, Hirokazu Tamamura

ORGANIC & BIOMOLECULAR CHEMISTRY   6 ( 23 )   4374 - 4377   2008

Versatile use of acid-catalyzed ring-opening of beta-aziridinyl-alpha,beta-enoates to stereoselective synthesis of peptidomimetics Reviewed

Hirokazu Tamamura, Tomohiro Tanaka, Hiroshi Tsutsumi, Koji Nemoto, Satoko Mizokami, Nami Ohashi, Shinya Oishi, Nobutaka Fujii

TETRAHEDRON   63 ( 37 )   9243 - 9254   2007.9

Therapeutic potential of the chemokine receptor CXCR4 antagonists as multifunctional agents Invited Reviewed

Hiroshi Tsutsumi, Tomohiro Tanaka, Nami Ohashi, Hiroyuki Masuno, Hirokazu Tamamura, Kenichi Hiramatsu, Takanobu Araki, Satoshi Ueda, Shinya Oishi, Nobutaka Fujii

BIOPOLYMERS   88 ( 2 )   279 - 289   2007

Development of Designed Bivalent Ligands for CXCR4 and Their Function on Receptor Binding

NOMURA Wataru, TANAKA Tomohiro, AOKI Toru, SOHMA Akira, AIKAWA Haruo, NARUMI Tetsuo, TAMAMURA Hirokazu

2011   79 - 80   2012.3

最新ペプチド合成技術とその創薬研究への応用. Invited

野村 渉, 田中智博, 相川春夫, 玉村啓和

多価結合型GPCRリガンドの合成とがん細胞イメージングへの応用（株式会社 メディカルドゥ   267 - 273   2012

フッ化物イオン応答型アミノ酸の開発と標的タンパク質精製ツールへの応用

山本純, 田中智博, 傳田将也, 戎野紘司, 重永章, 野村渉, 玉村啓和, 大高章

日本薬学会年会要旨集   132nd ( 2 )   2012

長さの調節が可能な二価結合型CXCR4リガンドの創製・蛍光ラベル化と応用

相川春夫, 野村渉, 鳴海哲夫, 田中智博, 玉村啓和

日本化学会講演予稿集   92nd ( 3 )   2012

ジピコリルアミンおよびアザマクロサイクル環を有する二核亜鉛錯体型CXCR4アンタゴニストの構造活性相関研究

紺野誠, 野村渉, 鳴海哲夫, 相川春夫, 玉村啓和, 田中智博, 橋本知恵, 大橋南美, 尾崎太郎, 相馬晃, 糸谷恭子, 村上努, 山本直樹

日本化学会講演予稿集   92nd ( 4 )   2012

標的タンパク質の効率的濃縮と同定を指向したトレーサブルリンカーの開発

山本純, 前田奈美, 田中智博, 傳田将也, 重永章, 野村渉, 玉村啓和, 大高章

日本薬学会年会要旨集   131st ( 2 )   2011

CXCR4二量化状態解析のための2価結合型リガンドの合成

相馬晃, 野村渉, 田中智博, 鳴海哲夫, 相川春夫, 玉村啓和

日本薬学会関東支部大会講演要旨集   55th   2011

蛍光ラベル化した二価結合型CXCR4リガンドの創製と応用

相川春夫, 野村渉, 鳴海哲夫, 田中智博, 玉村啓和

反応と合成の進歩シンポジウム講演要旨集   37th   2011

HIV-gp41の三量体構造に特異的な中和抗体を誘導する人工抗原ペプチド

野村渉, 相馬晃, 中原徹, 中原徹, 大庭賢二, 田中智博, 橋本知恵, 橋本知恵, 鳴海哲夫, 山本直樹, 玉村啓和, 玉村啓和

日本薬学会関東支部大会講演要旨集   54th   2010

HIV侵入の動的超分子機構を模倣した立体構造特異的人工抗原分子の創製

野村渉, 中原徹, 橋本知恵, 相馬晃, 田中智博, 鳴海哲夫, 玉村啓和, 大庭賢二, 山本直樹

反応と合成の進歩シンポジウム講演要旨集   36th   2010

HIV-1コレセプターCXCR4を基にした人工設計型抗原分子の開発

橋本知恵, 橋本知恵, 堤浩, 田中智博, 中原徹, 中原徹, 野村渉, 大庭賢二, 村上努, 山本直樹, 玉村啓和, 玉村啓和

日本薬学会年会要旨集   129th ( 2 )   2009

HIV-1コレセプターCXCR4を基にした人工設計型抗原分子の開発

橋本知恵, 橋本知恵, 野村渉, 田中智博, 中原徹, 中原徹, 鳴海哲夫, 大庭賢二, 村上努, 山本直樹, 玉村啓和, 玉村啓和

日本薬理学会関東部会プログラム・要旨集   120th   2009

HIV-gp41の三量体構造に特異的な中和抗体を誘導する人工抗原ペプチド

大矢亜紀, 中原徹, 中原徹, 野村渉, 大庭賢二, 田中智博, 橋本知恵, 橋本知恵, 鳴海哲夫, 村上努, 山本直樹, 玉村啓和, 玉村啓和

メディシナルケミストリーシンポジウム講演要旨集   28th   2009

HIV-1第二受容体CXCR4を基にした合成抗原分子の開発

橋本知恵, 橋本知恵, 野村渉, 田中智博, 鳴海哲夫, 大庭賢二, 山本直樹, 玉村啓和, 玉村啓和

メディシナルケミストリーシンポジウム講演要旨集   28th   2009

CXCR4特異的蛍光プローブの開発と薬剤スクリーニングへの応用

田中智博, 野村渉, 田部泰明, 田部泰明, 鳴海哲夫, 糸谷恭子, 大庭賢二, 山本直樹, 玉村啓和, 玉村啓和

日本薬理学会関東部会プログラム・要旨集   120th   2009

蛍光性CXCR4特異的リガンドの開発:スクリーニング及びイメージングへの展開

田中智博, 野村渉, 田部泰章, 田部泰章, 堤浩, 糸谷恭子, 大庭賢二, 村上努, 山本直樹, 玉村啓和, 玉村啓和

日本薬学会年会要旨集   129th ( 2 )   2009

蛍光標識PKCおよび光制御型ケージドジアシルグリセロール誘導体の合成と機能評価

大橋南美, 芹澤雄樹, 野村渉, 堤浩, 松本洋典, 奥田善章, 田中智博, 古田寿昭, 玉村啓和

反応と合成の進歩シンポジウム講演要旨集   34th   190 - 191   2008.10

新規pharmacophoreを有するCXCR4アンタゴニストの構造活性相関研究

TANAKA TOMOHIRO, TABE YASUAKI, OHASHI NAMI, HASEYAMA MASAKI, TSUTSUMI HIROSHI, NOMURA WATARU, ITOYA KYOKO, ESAKA AI, OISHI SHIN'YA, FUJII NOBUTAKA, WANG Z, PEIPER S C, EVANS B, TAMAMURA HIROKAZU

日本薬学会年会要旨集   128th ( 2 )   84   2008.3

蛍光性アンタゴニストを用いたCXCR4のイメージングと阻害剤のスクリーニング法の確立

田部泰章, 野村渉, 堤浩, 田中智博, 大庭賢二, 駒野淳, 山本直樹, 藤井信孝, 玉村啓和

日本化学会講演予稿集   88th ( 2 )   2008

標的タンパク質を特異的に蛍光検出する新規タグ‐プローブシステムの開発

堤浩, 大橋南美, 田中智博, 田部泰章, 阿部清一朗, 蓑友明, 玉村啓和

反応と合成の進歩シンポジウム講演要旨集   33rd   306 - 307   2007.10

Stereoselective synthesis of peptidomimetics based on acid-catalyzed ring-opening of beta-aziridinyl-alpha, beta-enoates

H. Tamamura, T. Tanaka, H. Tsutsumi, K. Nemoto, S. Mizokami, N. Ohashi

BIOPOLYMERS   88 ( 4 )   580 - 580   2007

Development of chemokine receptor CXCR4 antagonists using bio-mimetic strategy

H. Tamamura, T. Tanaka, H. Tsutsumi, N. Ohashi, K. Hiramatsu, T. Araki, A. Ojida, I. Hamachi, Z. Wang, S. C. Pelper, J. O. Trent, S. Ueda, S. Oishi, N. Fujii

BIOPOLYMERS   88 ( 4 )   577 - 577   2007

大環状ポリアミン型のホウ素中性子捕捉療法（BNCT）用含ホウ素薬剤の設計と合成

青木伸, 上田大貴, 田中智博, 鈴木実, 櫻井良憲

第39回メディシナルケミストリーシンポジウム  2022.11.23 

Design and Synthesis of Boron-Containing Macrocyclic Polyamines as Boron Neutron Capture Therapy (BNCT) Agents Invited

International Congress on Pure & Applied Chemistry Kona Kitabalu  2022.11.25 

ホウ素中性子捕捉療法のためのDNA標的型ホウ素薬剤の開発

上田大貴, 鈴木実, 櫻井良憲, 田中智博, 青木伸

第18回日本中性子捕捉療法学会学術大会  2022.10.18 

Analytical Sciences C （2024academic year） 1st semester  - 木3～4

Advanced Seminars in Drug Discovery and Drug Development (Biofuctional Analysis and Molecular Imaging) （2024academic year） special  - その他

Basic Physics （2024academic year） 1st semester  - 火1～2,金3～4

Basic Physics （2024academic year） 1st semester  - 火1～2,金3～4

Radiopharmaceuticals 1 （2024academic year） Third semester  - 月3～4

Next Generation Drugs （2024academic year） Third semester  - 木1～2

Inorganic・Radiopharmaceuticals （2024academic year） 3rd and 4th semester  - 月3～4

Inorganic・Radiopharmaceuticals （2024academic year） 3rd and 4th semester  - 月3～4

Inorganic・Radiopharmaceuticals （2024academic year） 3rd and 4th semester  - 月3～4

Inorganic・Radiopharmaceuticals （2024academic year） 3rd and 4th semester  - 月3～4

Experimental Physical Chemistry （2024academic year） 1st semester  - その他5～9

Experimental Physical Chemistry （2024academic year） 1st semester  - その他5～9

Biofuctional Analysis and Molecular Imaging （2024academic year） special  - その他

Advanced Lectures: Biofunctional Analysis and Molecular Imaging （2024academic year） special  - その他

Practice in Fundamental Pharmaceutical Sciences I （2024academic year） 1st semester  - その他5～9

Practice in Fundamental Pharmaceutical Sciences I （2024academic year） 1st semester  - その他5～9

Practice in Fundamental Pharmaceutical Sciences I （2024academic year） 1st semester  - その他5～9

Practice in Fundamental Pharmaceutical Sciences I （2024academic year） 1st semester  - その他5～9

Mechanism and diagnosis of human body （2023academic year） 1st semester  - 月3～4

Analytical Sciences and Physical Chemistry （2023academic year） special  - その他

Analytical Sciences 4 （2023academic year） 1st semester  - 木3～4

Analytical Sciences 4 （2023academic year） 1st semester  - 木3～4

Analytical Sciences C （2023academic year） 1st semester  - 木3～4

Analytical Sciences C （2023academic year） 1st semester  - 木3～4

Advanced Seminars in Drug Discovery and Drug Development (Biofuctional Analysis and Molecular Imaging) （2023academic year） special  - その他

Basic Physics （2023academic year） 1st semester  - 火5～6,金3～4

Basic Physics （2023academic year） 1st semester  - 火5～6,金3～4

Radiopharmaceuticals 1 （2023academic year） Third semester  - 月3～4

Inorganic・Radiopharmaceuticals （2023academic year） 3rd and 4th semester  - 月3～4

Inorganic・Radiopharmaceuticals （2023academic year） 3rd and 4th semester  - 月3～4

Experimental Physical Chemistry （2023academic year） 1st semester  - その他5～9

Experimental Physical Chemistry （2023academic year） 1st semester  - その他5～9

Biofuctional Analysis and Molecular Imaging （2023academic year） special  - その他

Advanced Lectures: Biofunctional Analysis and Molecular Imaging （2023academic year） special  - その他