Faculty Profiles - KATSUYAMA Takayuki

Papers - KATSUYAMA Takayuki

Division display 1 - 20 of about 88 ／ All the affair displays >>

Implications of serum calcitonin gene-related peptide and type I interferon in systemic lupus erythematosus-associated headaches

Shu Sugimoto, Yasuhiro Shimojima, Dai Kishida, Takanori Ichikawa, Ryota Takamatsu, Nobuyuki Yajima, Kunihiro Ichinose, Toshimasa Shimizu, Ryusuke Yoshimi, Takashi Kida, Takayuki Katsuyama, Yusuke Matsuo, Hiroshi Kajiyama, Ayuko Takatani, Yoshiki Sekijima

Lupus 2025.4

Publishing type：Research paper (scientific journal) Publisher：SAGE Publications

Objective

Headache is a common neurological symptom in patients with systemic lupus erythematosus (SLE). Calcitonin gene-related peptide (CGRP) is a potential chemical mediator of headaches, while type I interferon (IFN) plays a pivotal role in the immune system of SLE. This study investigated the implications of CGRP and type I IFNs as headache biomarkers in patients with SLE.

Methods

We used clinical information and serum samples from 144 patients with SLE from a Japanese multicenter cohort and a biobank. Serum CGRP, IFN-α, and IFN-β levels, which were measured using enzyme-linked immunoassay, were compared among patients with headache, those without headache, and 20 healthy controls (HC). These levels were compared based on the severity of daily disability caused by headaches as determined using the Migraine Disability Assessment.

Results

Of the 144 patients, 60 had headache (median age, 42 years; 56 women) and were significantly younger than patients without headache (median age, 49 years; 77 women) ( p < .005). Both groups had a median SLE Disease Activity Index 2000 score of 4.0, which was not significantly different, whereas photosensitivity was significantly more prevalent in patients with headache than in those without headache ( p < .05). Serum CGRP and IFN-α levels were not significantly different between patients with headache, those without headache, and HC. Serum IFN-β levels were significantly higher in patients with headache than in those without headache ( p < .005), while being significantly lower in both patients with and without headache than in HC ( p < .005). No significant differences in serum CGRP, IFN-α and IFN-β levels were observed based on the severity of daily disability related to headaches.

Conclusion

Serum CGRP and type I IFNs levels may not be involved in SLE-associated headaches.

DOI： 10.1177/09612033251332789

researchmap

Other Link： https://journals.sagepub.com/doi/full-xml/10.1177/09612033251332789

Dyspnea with Hemidiaphragm Elevation in a Patient with Giant Cell Arteritis: A Case Report

Yosuke Asano, Yoshinori Matsumoto, Natsuki Kubota, Yuya Terajima, Kazuya Matsumoto, Kenta Shidahara, Kei Hirose, Takato Nakadoi, Shoichi Nawachi, Yu Katayama, Yoshia Miyawaki, Eri Katsuyama, Takayuki Katsuyama, Mariko Takano-Narazaki, Ken-Ei Sada, Jun Wada

Internal Medicine 2025

Pericardial artery lymphoma in a patient with dermatomyositis: A case report. International journal

Kei Hirose, Takayuki Katsuyama, Natsuki Kubota, Yuya Terajima, Kazuya Matsumoto, Kenta Shidahara, Takato Nakadoi, Shoichi Nawachi, Yu Katayama, Yoshia Miyawaki, Eri Katsuyama, Mariko Narazaki-Takano, Yoshinori Matsumoto, Noboru Asada, Ken-Ei Sada, Jun Wada

Modern rheumatology case reports 2024.11

Language：English Publishing type：Research paper (scientific journal)

A woman in her 60s presented with erythema on both elbows, dyspnea on exertion, discomfort, and swelling of the left upper extremity, followed by swelling and myalgia of the right upper and lower extremities. She was diagnosed with anti-TIF1γ antibody-positive dermatomyositis with interstitial pneumonia. The initial screening tests for malignant diseases including contrast-enhanced CT, upper and lower endoscopy, and gynecological examination did not reveal any obvious abnormalities. The patient experienced two recurrent episodes of muscle weakness and dysphagia during treatment with intravenous glucocorticoids and cyclophosphamide. Five months after diagnosis, a bone marrow biopsy and positron emission tomography- computed tomography (PET-CT) scan revealed a coronary malignant lymphoma with suspected systemic metastasis. Although chemotherapy was initiated, the patient ultimately succumbed to alveolar hemorrhage. Coronary lymphoma is very rare and there has been no report of a cases associated with myositis. PET-CT may be useful for searching malignancy in anti-TIF1γ antibody-positive dermatomyositis cases of recurrent relapse.

DOI： 10.1093/mrcr/rxae065

PubMed

researchmap

Association between discontinuity of care and patient trust in the usual rheumatologist among patients with systemic lupus erythematosus: a cross-sectional study

Yu Katayama, Yoshia Miyawaki, Kenta Shidahara, Shoichi Nawachi, Yosuke Asano, Eri Katsuyama, Takayuki Katsuyama, Mariko Takano-Narazaki, Yoshinori Matsumoto, Nao Oguro, Nobuyuki Yajima, Yuichi Ishikawa, Natsuki Sakurai, Chiharu Hidekawa, Ryusuke Yoshimi, Shigeru Ohno, Takanori Ichikawa, Dai Kishida, Yasuhiro Shimojima, Ken-ei Sada, Jun Wada, David H. Thom, Noriaki Kurita

Arthritis Research & Therapy 26 ( 1 ) 2024.11

Histological differences related to autophagy in the minor salivary gland between primary and secondary types of Sjögren's syndrome. International journal

Hitomi Ono-Minagi, Tsutomu Nohno, Kiyofumi Takabatake, Takehiro Tanaka, Takayuki Katsuyama, Kohta Miyawaki, Jun Wada, Soichiro Ibaragi, Seiji Iida, Tadashi Yoshino, Hitoshi Nagatsuka, Takayoshi Sakai, Hideyo Ohuchi

BMC oral health 24 ( 1 ) 1099 - 1099 2024.9

Language：English Publishing type：Research paper (scientific journal)

Some forms of Sjögren's syndrome (SS) follow a clinical course accompanied by systemic symptoms caused by lymphocyte infiltration and proliferation in the liver, kidneys, and other organs. To better understand the clinical outcomes of SS, here we used minor salivary gland tissues from patients and examine their molecular, biological, and pathological characteristics. A retrospective study was performed, combining clinical data and formalin-fixed paraffin-embedded (FFPE) samples from female patients over 60 years of age who underwent biopsies at Okayama University Hospital. We employed direct digital RNA counting with nCounter® and multiplex immunofluorescence analysis with a PhenoCycler™ on the labial gland biopsies. We compared FFPE samples from SS patients who presented with other connective tissue diseases (secondary SS) with those from stable SS patients with symptoms restricted to the exocrine glands (primary SS). Secondary SS tissues showed enhanced epithelial damage and lymphocytic infiltration accompanied by elevated expression of autophagy marker genes in the immune cells of the labial glands. The close intercellular distance between helper T cells and B cells positive for autophagy-associated molecules suggests accelerated autophagy in these lymphocytes and potential B cell activation by helper T cells. These findings indicate that examination of FFPE samples from labial gland biopsies can be an effective tool for evaluating molecular histological differences between secondary and primary SS through multiplexed analysis of gene expression and tissue imaging.

DOI： 10.1186/s12903-024-04869-4

PubMed

researchmap

不全型Behcet病にみられた好中球浸潤を伴う急性尿細管間質性腎炎の一例

内田成彦, 田中景子, 三宅広将, 久保田菜月, 森本志帆, 志田原健太, 勝山隆行, 田邊克幸, 和田淳

日本腎臓学会誌 66 ( 6-W ) 1119 - 1119 2024.9

Successful treatment for life threatening recurrent non-traumatic rectus sheath hematoma in a case with microscopic polyangiitis with rapidly progressive glomerulonephritis.

Hiroyuki Nakanoh, Hidemi Takeuchi, Morimoto Shiho, Yuya Terajima, Shugo Okamoto, Yasuhiro Onishi, Keiko Tanaka, Takayuki Katsuyama, Kenji Tsuji, Yoshinori Matsumoto, Katsuyuki Tanabe, Hiroshi Morinaga, Mayu Uka, Koji Tomita, Haruhito A Uchida, Takao Hiraki, Jun Wada

Internal medicine (Tokyo, Japan) 2024.4

Language：English Publishing type：Research paper (scientific journal)

A 68-year-old woman was admitted to our hospital because of a rapid progression of renal dysfunction with positive myeloperoxidase antineutrophil cytoplasmic antibody and was diagnosed with rapidly progressive glomerulonephritis associated with microscopic polyangiitis (MPA). Severe right rectus sheath hematoma (RSH) bleeding from the inferior epigastric artery developed after starting hemodialysis, which required 4 transarterial embolizations due to recurrent bleeding. After additional treatment with methylprednisolone pulse therapy and rituximab, no rebleeding occurred. Although the giant hematoma reached the pelvis, it shrank spontaneously without any intervention. Nontraumatic RSH should therefore be considered when treating patients with multiple risk factors.

DOI： 10.2169/internalmedicine.3239-23

PubMed

researchmap

Discontinuity of care and trust in usual physician among patients with systemic lupus erythematosus

Katayama Yu, Miyawaki Yoshia, Shidahara Kenta, Nawachi Shoichi, Asano Yosuke, Katsuyama Eri, Katsuyama Takayuki, Takano-Narazaki Mariko, Matsumoto Yoshinori, Oguro Nao, Ishikawa Yuichi, Sakurai Natsuki, Hidekawa Chiharu, Ohno Shigeru, Ichikawa Takanori, Kishida Dai, Shimojima Yasuhiro, Sada Ken-ei, Wada Jun, Thom David, Kurita Noriaki† (†last author)

medRxiv 2024.03.13.24304255 2024.3

婦人科悪性腫瘍の摘出後,速やかにCKが正常化したHMGCR抗体陽性壊死性ミオパチーの一例

古山怜奈, 勝山恵理, 久保田菜月, 寺嶋悠也, 松本和也, 廣瀬啓, 志田原健太, 縄稚翔一, 中土井崇人, 片山祐, 宮脇義亜, 勝山隆行, 楢崎真理子, 松本佳則, 和田淳

日本リウマチ学会総会・学術集会プログラム・抄録集 68回 915 - 915 2024.3

Pseudo pseudo Meigs syndromeを呈したSLEの1例

中山菜々子, 片山祐, 久保田菜月, 寺嶋悠也, 松本和也, 廣瀬啓, 志田原健太, 縄稚翔一, 中土井崇人, 宮脇義亜, 勝山恵理, 勝山隆行, 楢崎真理子, 松本佳則, 和田淳

日本リウマチ学会総会・学術集会プログラム・抄録集 68回 914 - 914 2024.3

TAFRO症候群に緩徐進行1型糖尿病を合併した1例

喜舎場朝基, 片山祐, 久保田菜月, 寺嶋悠也, 松本和也, 廣瀬啓, 志田原健太, 縄稚翔一, 中土井崇人, 宮脇義亜, 勝山恵理, 勝山隆行, 楢崎真理子, 松本佳則, 和田淳

日本リウマチ学会総会・学術集会プログラム・抄録集 68回 914 - 914 2024.3

漿液性網膜剥離と蛋白漏出胃腸症を合併した全身性エリテマトーデスの一例

都明希, 勝山隆行, 久保田菜月, 寺嶋悠也, 松本和也, 廣瀬啓, 志田原健太, 縄稚翔一, 中土井崇人, 片山祐, 宮脇義亜, 勝山恵理, 楢崎真理子, 松本佳則, 和田淳

日本リウマチ学会総会・学術集会プログラム・抄録集 68回 914 - 914 2024.3

不全型ベーチェット病に急性尿細管間質性腎炎を合併した一例

有地萌音, 勝山恵理, 久保田菜月, 寺嶋悠也, 松本和也, 廣瀬啓, 志田原健太, 縄稚翔一, 中土井崇人, 片山祐, 宮脇義亜, 勝山隆行, 楢崎真理子, 松本佳則, 和田淳

日本リウマチ学会総会・学術集会プログラム・抄録集 68回 909 - 909 2024.3

好酸球性多発血管炎性肉芽腫症(EGPA)との鑑別に苦慮した好酸球性大腸炎(EoC)の一例

寺嶋悠也, 宮脇義亜, 久保田菜月, 松本和也, 廣瀬啓, 志田原健太, 中土井崇人, 縄稚翔一, 片山祐, 勝山恵理, 勝山隆行, 楢崎真理子, 松本佳則, 和田淳

日本リウマチ学会総会・学術集会プログラム・抄録集 68回 889 - 889 2024.3

重症感染症を合併した難治性中小型血管炎に対してアバコパンとγグロブリン大量静注療法(IVIG)で寛解導入に至った1例

小松原悠, 松本佳則, 久保田菜月, 寺嶋悠也, 松本和也, 廣瀬啓, 志田原健太, 縄稚翔一, 中土井崇人, 片山祐, 宮脇義亜, 勝山恵理, 勝山隆行, 楢崎真理子, 和田淳

日本リウマチ学会総会・学術集会プログラム・抄録集 68回 913 - 913 2024.3

骨免疫制御蛋白に着目した関節リウマチ病態形成メカニズムの解明

三前英恵, 松本佳則, 松本和也, 浅野洋介, 久保田菜月, 寺嶋悠也, 廣瀬啓, 縄稚翔一, 志田原健太, 中土井崇人, 片山祐, 宮脇義亜, 勝山恵理, 勝山隆行, 楢崎真理子, 和田淳

日本リウマチ学会総会・学術集会プログラム・抄録集 68回 910 - 910 2024.3

中小型血管炎:治療3 リツキシマブ1000mgの2回投与により寛解導入を行なった初発の顕微鏡的多発血管炎および多発血管炎性肉芽腫症の8例に関する記述研究

松本和也, 宮脇義亜, 久保田菜月, 寺嶋悠也, 廣瀬啓, 志田原健太, 中土井崇人, 縄稚翔一, 片山祐, 勝山隆行, 勝山恵理, 楢崎真理子, 松本佳則, 佐田憲映, 和田淳

日本リウマチ学会総会・学術集会プログラム・抄録集 68回 581 - 581 2024.3

上腸間膜動脈周囲軟部影から血管炎が疑われたが膵癌と判明した一例

志田原健太, 片山祐, 久保田菜月, 寺嶋悠也, 松本和也, 廣瀬啓, 中土井崇人, 縄稚翔一, 宮脇義亜, 勝山恵理, 勝山隆行, 楢崎真理子, 松本佳則, 和田淳

日本リウマチ学会総会・学術集会プログラム・抄録集 68回 881 - 881 2024.3

二次性の結節性多発動脈炎の発症したびまん性大細胞型B細胞性リンパ腫の一例

久保田菜月, 宮脇義亜, 寺嶋悠也, 松本和也, 廣瀬啓, 志田原健太, 中土井崇人, 縄稚翔一, 片山祐, 勝山隆行, 勝山恵理, 楢崎真理子, 松本佳則, 和田淳

日本リウマチ学会総会・学術集会プログラム・抄録集 68回 821 - 821 2024.3

The first presentation of a case of nail-patella syndrome newly diagnosed at the onset of rheumatoid arthritis: a case report. International journal

Kazuya Matsumoto, Yoshinori Matsumoto, Shoichi Nawachi, Yosuke Asano, Yu Katayama, Yoshia Miyawaki, Takayuki Katsuyama, Eri Katsuyama, Yoshihisa Nasu, Ken-Ei Sada, Jun Wada

BMC musculoskeletal disorders 25 ( 1 ) 139 - 139 2024.2

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Nail-patella syndrome (NPS) is a rare autosomal dominant disorder that is characterized by dysplasia of the nails, hypoplasia and/or dislocation of the patella and the presence of iliac horns. Using the CARE guidelines, we present the first reported case of NPS that was newly diagnosed at the onset of rheumatoid arthritis (RA). CASE PRESENTATION: A 74-year-old man was admitted to our hospital due to an 8-month history of arthralgia in bilateral wrists, elbows and fingers. He had a past history of glaucoma and left patella dislocation that had been operatively recentered at the age of 15 years. Laboratory data showed elevated levels of serum C-reactive protein and rheumatoid factor and an elevated titer of anti-SS-A antibodies, while estimated glomerular filtration rate (eGFR), titers of other antibodies and the results of a urinary test were normal. An X-ray showed deformity of bilateral radial heads and the right elbow, and magnetic resonance imaging (MRI) of his hands showed synovitis and erosion in the multiple swollen joints of the wrists and fingers. In addition to these typical features of RA, he had bilateral thumb nail dysplasia with mild hypoplasia of bilateral patellae and iliac horns as shown by the X-ray. He was diagnosed as having autosomal dominant disorder NPS co-existing with RA and he was treated with methotrexate in combination with an oral Janus kinase (JAK) inhibitor, leading to induction of remission. CONCLUSIONS: We have presented a rare case of NPS that was newly diagnosed at the onset of RA. Clinical and radiographic findings of NPS are highlighted in this case report for diagnosing NPS on the basis of typical manifestations.

DOI： 10.1186/s12891-024-07242-2

PubMed

researchmap

　 PREV - NEXT 　

< KATSUYAMA Takayuki >

Papers - KATSUYAMA Takayuki