Faculty Profiles - FUJIWARA Toshiyoshi

MISC - FUJIWARA Toshiyoshi

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Heparanase expression correlates with invasion and poor prognosis in gastric cancers.

Takaoka, M, Naomoto, Y, Ohkawa, T, Uetsuka, H, Shirakawa, Y, Uno, F, Fujiwara, T, Gunduz, M, Nagatsuka, H, Nakajima, M, Tanaka, N, Haisa, M

Lab. Invest. 2003

アデノウイルスを用いた遺伝子治療

藤原俊義, 田中紀章

Surgery Frontier 10,372-379 2003

制癌剤の新しい視点 1）アデノウイルスベクター

西崎正彦, 藤原俊義, 田中紀章

Surgery Frontier 10,201-207 2003

消化器癌におけるmolecular targeting療法としての遺伝子治療

藤原俊義, 田中紀章

G. I. Research 11,11-18 2003

肺癌の遺伝子治療

香川俊輔, 藤原俊義, 田中紀章

病理と臨床 21,519-522 2003

肺癌に対する遺伝子治療：その現況と展望

藤原俊義, 田中紀章

癌と化学療法 30,460-467 2003

遺伝子治療. 「肺癌：診断・治療の最前線」

藤原俊義, 田中紀章

癌の臨床（臨時増刊号） 49,1127-1136 2003

癌の遺伝子治療

藤原俊義, 田中紀章

医学のあゆみ「先端外科医療の最前線」 205,575-580 2003

遺伝子治療の実際

香川俊輔, 藤原俊義, 田中紀章

癌と化学療法 30,193-197 2003

複製可能ウイルスを用いた遺伝子治療の進歩：制限増殖型アデノウイルス

藤原俊義, 田中紀章

分子細胞治療 2,249-255 2003

肺癌治療と遺伝子多型

藤原俊義, 田中紀章

癌治療と宿主 15,29-34 2003

p53を標的とした治療

藤原俊義, 田中紀章

呼吸器科 4,401-409 2003

p53をターゲットとした肺癌治療

藤原俊義, 田中紀章

肺癌の臨床 5,295-302 2003

アポトーシス誘導遺伝子p53による癌の遺伝子治療

藤原俊義, 田中紀章

細胞 35,558-560 2003

Clinical study of adenoviral mediated p53 gene therapy for non-small cell lung cancer in Japan

Shunsuke Kagawa, Toshiyoshi Fujiwara, Noriaki Tanaka

Gan to kagaku ryoho. Cancer & chemotherapy 30 ( 2 ) 193 - 197 2003

Language：Japanese Publishing type：Book review, literature introduction, etc.

The prognosis in case of non-small cell lung cancer (NSCLC) remains poor, and novel treatment modalities are urgently needed for advanced NSCLC. Backed by advances in the understanding of cancer biology, gene therapy has been developed in recent years. The p53 gene is altered in over 50% of cancers and has been extensively studied as a tumor suppressor gene. Adenoviral-mediated p53 gene transfer is currently under clinical evaluation worldwide for the treatment of cancer. We are now conducting a phase I study of Ad-p53 for advanced NSCLC patients in Japan. As an interim report, we provide a brief summary of the current status of this study, highlighting the safety and clinical efficacy of Ad-p53. As of September 2002, 13 patients were enrolled to this study, and safety and antitumor effects have been noted.

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肺癌に対する遺伝子治療の現状と展望 : 非増殖型ベクターから制限増殖型ベクターへ(肺癌における遺伝子情報とその応用)(ワークショップ8)

藤原俊義, 川嶋健, 香川俊輔, 西崎正彦, 田中紀章

肺癌 42 ( 5 ) 360 - 360 2002.10

非小細胞肺癌に対する集学的治療としてのp53遺伝子治療 : ドセタキセル/放射線療法との併用効果の基礎的検討

西崎正彦, 藤原俊義, 香川俊輔, 田中紀章, Ji Lin, Roth Jack

肺癌 42 ( 5 ) 403 - 403 2002.10

腫よう特異的増殖可能アデノウイルス(TRAD)の開発テロメラーゼ発現ヒト癌細胞における選択的腫よう融解の誘導

川嶋健, 藤原俊義, 梅岡達生, 滝正樹, 京哲, 香川俊輔, 西崎正彦, 田中紀章

日本癌学会総会記事 61st 186 2002.8

蛍光イメージングによる癌特異的GFP遺伝子発現の検出癌特異的増殖可能アデノウイルスを用いた非侵襲的な生体内癌組織診断

梅岡達生, 藤原俊義, 川嶋健, 常光洋輔, 京哲, 香川俊輔, 西崎正彦, 田中紀章

日本癌学会総会記事 61st 404 2002.8

Adenovirus-mediated p14ARF gene transfer cooperates with Ad5CMV-p53 to induce apoptosis in human cancer cells

Yasuhisa Tango, Toshiyoshi Fujiwara, Takahiro Itoshima, Yoshiko Takata, Kou Katsuda, Futoshi Uno, Shoichiro Ohtani, Tohru Tani, Jack A. Roth, Noriaki Tanaka

Human Gene Therapy 13 ( 11 ) 1373 - 1382 2002.7

Language：English

p14ARF, a product of theINK4A/ARF locus, induces p53 upregulation by neutralizing the effects of MDM2, a transcriptional target of p53 that antagonizes its function. Here we report that adenovirus-mediated p14ARF gene transfer leads to the accumulation of ectopically transduced p53 and to apoptosis in human cancer cells. We constructed an adenoviral vector expressing p14ARF (Ad-ARF) and examined its synergistic effect with p53-expressing adenovirus (Ad5CMV-p53 or Ad-p53) in human lung and esophageal cancer cells. Simultaneous Ad-ARF and Ad-p53 infection increased p53 protein levels not only in a wild-type p53-expressing cell line, but also in cell lines with deleted p53. This resulted in a significant in vitro cytotoxicity compared with Ad-p53 infection alone. Coinfection of Ad-ARF and Ad-p53 also resulted in an increase in expression of p53-inducible genes, including p21WAF-1/Cip1, p53R2, and Noxa. In addition, the growth of human lung cancer tumors subcutaneously implanted into nu/nu mice was inhibited significantly by intratumoral injection with Ad-ARF and Ad-p53. Our data demonstrate that overexpression of ectopic p14ARF may render cells more sensitive to p53-mediated apoptosis, an outcome that has important implications for the treatment of human cancers.

DOI： 10.1089/104303402760128595

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