研究者詳細 - 藤原　俊義

論文 - 藤原　俊義

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胃癌の腹膜転移に対する新規の腹腔内ウイルス療法(Novel intraperitoneal virotherapy for the peritoneal metastasis of gastric cancer)

Kikuchi Satoru, Ishikawa Wataru, Ogawa Toshihiro, Kuroda Shinji, Kuwada Kazuya, Nishizaki Masahiko, Kagawa Shunsuke, Fujiwara Toshiyoshi

日本胃癌学会総会記事 91回 337 - 337 2019年2月

観音開き法による食道残胃吻合を行ったLAPGとLATGとの中期および長期成績比較(Mid- and long-term comparison of LAPG with double-flap esophagogastrostomy and LATG)

Kuroda Shinji, Nishizaki Masahiko, Kikuchi Satoru, Tsumura Tomoko, Kuwada Kazuya, Kagawa Shunsuke, Fujiwara Toshiyoshi

日本胃癌学会総会記事 91回 302 - 302 2019年2月

近位胃切除術後のEGJCに対するDFTを使用した弁形成食道胃吻合術(Valvutoplastic esophagogastrostomy using DFT for EGJC after proximal gastrectomy)

Nishizaki Masahiko, Kuroda Shinji, Noma Kazuhiro, Kikuchi Satoru, Kuwada Kazuya, Tanabe Shunsuke, Kagawa Shunsuke, Shirakawa Yasuhiro, Fujiwara Toshiyoshi

日本胃癌学会総会記事 91回 273 - 273 2019年2月

Multicenter retrospective study to evaluate the efficacy and safety of the double-flap technique as antireflux esophagogastrostomy after proximal gastrectomy (rD-FLAP Study).

Shinji Kuroda, Yasuhiro Choda, Shinya Otsuka, Satoshi Ueyama, Norimitsu Tanaka, Atsushi Muraoka, Shinji Hato, Toshikazu Kimura, Kohji Tanakaya, Satoru Kikuchi, Shunsuke Tanabe, Kazuhiro Noma, Masahiko Nishizaki, Shunsuke Kagawa, Yasuhiro Shirakawa, Yasuaki Kamikawa, Toshiyoshi Fujiwara

Annals of gastroenterological surgery 3 ( 1 ) 96 - 103 2019年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

Aim: As a result of the difficulty in effective prevention of gastroesophageal reflux, no standard reconstruction procedure after proximal gastrectomy (PG) has yet been established. The double-flap technique (DFT), or Kamikawa procedure, is an antireflux reconstruction procedure in esophagogastrostomy. The efficacy of DFT has recently been reported in several studies. However, these were all single-center studies with a limited number of cases. Methods: We conducted a multicenter retrospective study in which patients who underwent DFT, irrespective of disease type and reconstruction approach, at each participating institution between 1996 and 2015 were registered. Primary endpoint was incidence of reflux esophagitis at 1-year after surgery, and secondary endpoint was incidence of anastomosis-related complications. Results: Of 546 patients who were eligible for this study, 464 patients who had endoscopic examination at 1-year follow up were evaluated for reflux esophagitis. Incidence of reflux esophagitis of all grades was 10.6% and that of grade B or higher was 6.0%. Male gender and anastomosis located in the mediastinum/intra-thorax were independent risk factors for grade B or higher reflux esophagitis (odds ratio [OR]: 4.21, 95% confidence interval [CI]: 1.44-10.9, P = 0.0109). Total incidence of anastomosis-related complications was 7.2%, including leakage in 1.5%, strictures in 5.5% and bleeding in 0.6% of cases. Laparoscopic reconstruction was the only independent risk factor for anastomosis-related complications (OR: 3.93, 95% CI: 1.93-7.80, P = 0.0003). Conclusion: Double-flap technique might be a feasible option after PG for effective prevention of reflux, although anastomotic stricture is a complication that must be well-prepared for.

DOI： 10.1002/ags3.12216

PubMed

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外科医のトレーニング技術の継承とはカダバートレーニングにおける技術の継承

近藤喜太, 信岡大輔, 黒田新士, 前田直見, 西崎正彦, 白川靖博, 藤原俊義

日本外科学会雑誌 120 ( 1 ) 105 - 107 2019年1月

【腹腔鏡下胃切除後体腔内再建のKnack & Pitfalls】腹腔鏡下噴門側胃切除術観音開き法(上川法)による再建

西崎正彦, 黒田新士, 野間和広, 菊地覚次, 白川靖博, 藤原俊義

手術 73 ( 1 ) 55 - 59 2019年1月

Photoimmunotherapy for cancer-associated fibroblasts targeting fibroblast activation protein in human esophageal squamous cell carcinoma. 査読国際誌

Watanabe S, Noma K, Ohara T, Kashima H, Sato H, Kato T, Urano S, Katsube R, Hashimoto Y, Tazawa H, Kagawa S, Shirakawa Y, Kobayashi H, Fujiwara T

Cancer biology & therapy 20 ( 9 ) 1234 - 1248 2019年

Intraperitoneal cancer-immune microenvironment promotes peritoneal dissemination of gastric cancer. 査読国際誌

Sakamoto S, Kagawa S, Kuwada K, Ito A, Kajioka H, Kakiuchi Y, Watanabe M, Kagawa T, Yoshida R, Kikuchi S, Kuroda S, Tazawa H, Fujiwara T

Oncoimmunology 8 ( 12 ) e1671760 2019年

Forefront of perioperative team medicine for esophageal cancer surgery

Yasuhiro Shirakawa, Shunsuke Tanabe, Toshiyoshi Fujiwara

Journal of Japanese Society of Gastroenterology 116 ( 2 ) 138 - 144 2019年

The epithelial-to-mesenchymal transition induced by tumor-associated macrophages confers chemoresistance in peritoneally disseminated pancreatic cancer. 査読国際誌

Kuwada K, Kagawa S, Yoshida R, Sakamoto S, Ito A, Watanabe M, Ieda T, Kuroda S, Kikuchi S, Tazawa H, Fujiwara T

Journal of experimental & clinical cancer research : CR 37 ( 1 ) 307 - 307 2018年12月

上腹部開腹歴を有する腹腔鏡下胃切除術における安全性の検討

津村朋子, 黒田新士, 桑田和也, 菊池覚次, 西崎正彦, 香川俊輔, 白川靖博, 藤原俊義

日本内視鏡外科学会雑誌 23 ( 7 ) OS115 - 5 2018年12月

taTMEを安全に導入、普及させるためのcadaver surgical trainingの役割

戸嶋俊明, 近藤喜太, 信岡大輔, 黒田新士, 前田直見, 寺石文則, 白川靖博, 香川俊輔, 藤原俊義

日本内視鏡外科学会雑誌 23 ( 7 ) OS78 - 7 2018年12月

Closed-LECS手技の確立と今後の可能性早期胃癌、十二指腸病変への応用

菊地覚次, 西崎正彦, 黒田新士, 桑田和也, 津村朋子, 香川俊輔, 白川靖博, 藤原俊義

日本内視鏡外科学会雑誌 23 ( 7 ) OS23 - 2 2018年12月

上部胃癌に対する再建法を考える腹腔鏡下噴門側胃切除術における観音開き法再建の中長期成績

西崎正彦, 黒田新士, 菊地覚次, 桑田和也, 津村朋子, 田邊俊介, 野間和広, 香川俊輔, 白川靖博, 藤原俊義

日本内視鏡外科学会雑誌 23 ( 7 ) WS12 - 7 2018年12月

内視鏡外科におけるCadaver教育が果たすべき役割と未来

近藤喜太, 前田直見, 黒田新士, 信岡大輔, 西崎正彦, 白川靖博, 藤原俊義

日本内視鏡外科学会雑誌 23 ( 7 ) EDS - 2 2018年12月

Prognostic Factors for Pediatric Living Donor Liver Transplantation: Impact of Zero-mortality Transplant for Cholestatic Diseases.

Takahito Yagi, Kosei Takagi, Yuzo Umeda, Ryuichi Yoshida, Daisuke Nobuoka, Takashi Kuise, Toshiyoshi Fujiwara

Acta medica Okayama 72 ( 6 ) 567 - 576 2018年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

Living donor liver transplantation (LDLT) is the final therapeutic arm for pediatric end-stage liver diseases. Toward the goal of achieving further improvement in LDLT survival, we investigated factors affecting recipient survival. We evaluated the prognostic factors of 60 pediatric recipients (< 16 years old) who underwent LDLT between 1997 and 2015. In a univariate analysis, non-cholestatic (NCS) disease, graft/recipient body weight ratio, cold and warm ischemic times, and intraoperative blood loss were significant factors impacting survival. In a multivariate analysis, NCS disease was the only significant factor worsening survival (p=0.0021). One-and 5-year survival rates for the cholestatic disease (CS, n=43) and NCS (n=17) groups were 100% vs. 70.6% and 97.4% vs. 58.8% (p=0.004, log-rank). Intergroup comparisons revealed that CS was significantly associated with operation time, cold ischemia, hepatomegaly of the native liver, and portal plasty. These data suggest that a cirrhotic, swollen, artery-dominant liver did not increase graft size-related risks despite the surgical complexity of preceding operations. The NCS group's poorer survival originated from recurrence of the primary disease and liver manifestation of systemic disease untreatable by transplantation. Improving the survival of pediatric recipients requires intensive efforts to prevent primary disease relapse and more rapid diagnoses to exclude contraindications from NCS disease.

DOI： 10.18926/AMO/56374

PubMed

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手術既往を有する炎症性腸疾患に対する腹腔鏡手術完遂のための工夫

小松泰浩, 近藤喜太, 三村直毅, 戸嶋俊明, 寺石文則, 藤原俊義

日本内視鏡外科学会雑誌 23 ( 7 ) OS53 - 1 2018年12月