研究者詳細 - 楊　家家

論文 - 楊　家家

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Tactile angle discriminability improvement: contributions of working memory training and continuous attended sensory input 査読

Wu Wang, Jiajia Yang, Yinghua Yu, Huazhi Li, Yulong Liu, Yiyang Yu, Jiabin Yu, Xiaoyu Tang, Jingjing Yang, Satoshi Takahashi, Yoshimichi Ejima, Jinglong Wu

Journal of Neurophysiology 127 ( 5 ) 1398 - 1406 2022年5月

担当区分：責任著者掲載種別：研究論文（学術雑誌）出版者・発行元：American Physiological Society

Perceptual learning is not always specific to the trained task and stimuli. We demonstrate that both continuous attended sensory input and improved WM capacity can be used to enhance tactile angle discrimination (TAD) ability. Moreover, WM capacity improvement is important in generalizing the training effect to the TAD ability. These findings contribute to understanding the mechanism of perceptual learning generalization across tasks.

DOI： 10.1152/jn.00529.2021

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Layer-specific activation in human primary somatosensory cortex during tactile temporal prediction error processing 査読国際誌

Yinghua Yu, Laurentius Huber, Jiajia Yang, Masaki Fukunaga, Yuhui Chai, David C. Jangraw, Gang Chen, Daniel A. Handwerker, Peter J. Molfese, Yoshimichi Ejima, Norihiro Sadato, Jinglong Wu, Peter A. Bandettini

NeuroImage 248 118867 - 118867 2022年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Elsevier BV

The human brain continuously generates predictions of incoming sensory input and calculates corresponding prediction errors from the perceived inputs to update internal predictions. In human primary somatosensory cortex (area 3b), different cortical layers are involved in receiving the sensory input and generation of error signals. It remains unknown, however, how the layers in the human area 3b contribute to the temporal prediction error processing. To investigate prediction error representation in the area 3b across layers, we acquired layer-specific functional magnetic resonance imaging (fMRI) data at 7T from human area 3b during a task of index finger poking with no-delay, short-delay and long-delay touching sequences. We demonstrate that all three tasks increased activity in both superficial and deep layers of area 3b compared to the random sensory input. The fMRI signal was differentially modulated solely in the deep layers rather than the superficial layers of area 3b by the delay time. Compared with the no-delay stimuli, activity was greater in the deep layers of area 3b during the short-delay stimuli but lower during the long-delay stimuli. This difference activity features in the superficial and deep layers suggest distinct functional contributions of area 3b layers to tactile temporal prediction error processing. The functional segregation in area 3b across layers may reflect that the excitatory and inhibitory interplay in the sensory cortex contributions to flexible communication between cortical layers or between cortical areas.

DOI： 10.1016/j.neuroimage.2021.118867

PubMed

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Global surface features contribute to human haptic roughness estimations 査読

Huazhi Li, Jiajia Yang, Yinghua Yu, Wu Wang, Yulong Liu, Mengni Zhou, Qingqing Li, Jingjing Yang, Shiping Shao, Satoshi Takahashi, Yoshimichi Ejima, Jinglong Wu

Experimental Brain Research 240 ( 3 ) 773 - 789 2022年3月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

Abstract

Previous studies have paid special attention to the relationship between local features (e.g., raised dots) and human roughness perception. However, the relationship between global features (e.g., curved surface) and haptic roughness perception is still unclear. In the present study, a series of roughness estimation experiments was performed to investigate how global features affect human roughness perception. In each experiment, participants were asked to estimate the roughness of a series of haptic stimuli that combined local features (raised dots) and global features (sinusoidal-like curves). Experiments were designed to reveal whether global features changed their haptic roughness estimation. Furthermore, the present study tested whether the exploration method (direct, indirect, and static) changed haptic roughness estimations and examined the contribution of global features to roughness estimations. The results showed that sinusoidal-like curved surfaces with small periods were perceived to be rougher than those with large periods, while the direction of finger movement and indirect exploration did not change this phenomenon. Furthermore, the influence of global features on roughness was modulated by local features, regardless of whether raised-dot surfaces or smooth surfaces were used. Taken together, these findings suggested that an object’s global features contribute to haptic roughness perceptions, while local features change the weight of the contribution that global features make to haptic roughness perceptions.

DOI： 10.1007/s00221-021-06289-0

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その他リンク： https://link.springer.com/article/10.1007/s00221-021-06289-0/fulltext.html

Linking cortical circuit models to human cognition with laminar fMRI 査読

Jiajia Yang, Laurentius Huber, Yinghua Yu, Peter A. Bandettini

Neuroscience & Biobehavioral Reviews 128 467 - 478 2021年7月

Different activation signatures in the primary sensorimotor and higher-level regions for haptic three-dimensional curved surface exploration 査読

Jiajia Yang, Peter J. Molfese, Yinghua Yu, Daniel A. Handwerker, Gang Chen, Paul A. Taylor, Yoshimichi Ejima, Jinglong Wu, Peter A. Bandettini

NeuroImage 231 117754 - 117754 2021年5月

Functional heterogeneity in the left lateral posterior parietal cortex during visual and haptic crossmodal dot‐surface matching 査読

Jiajia Yang, Yinghua Yu, Hiroaki Shigemasu, Hiroshi Kadota, Kiyoshi Nakahara, Takanori Kochiyama, Yoshimichi Ejima, Jinglong Wu

Brain and Behavior 11 ( 3 ) 2021年3月

Tactile Semiautomatic Passive-Finger Angle Stimulator (TSPAS) 査読国際誌

Wu Wang, Jiajia Yang, Yinghua Yu, Qiong Wu, Satoshi Takahashi, Yoshimichi Ejima, Jinglong Wu

Journal of Visualized Experiments ( 161 ) 2020年7月

Tactile angle discriminability improvement: roles of training time intervals and different types of training tasks 査読

Wu W, Yang J, Yu Y, Wu Q, Yu J, Takahashi S, Ejima Y, Wu J

Journal of Neurophysiology 2019年9月

超高磁場・高精細レイヤーfMRI技術によるヒト大脳皮質の層別活動の可視化招待

楊家家, 于英花

Medical Science Digest 45 ( 7 ) 418 - 421 2019年6月

Layer-specific Activation of Sensory Input and Predictive Feedback in the Human Primary Somatosensory Cortex 査読国際誌

Yu Y, Huber L, Yang J, Jangraw DC, Handwerker DA, Molfese P, Chen G, Ejima Y, Wu J, Bandettini PA

Science Advances 5 ( 5 ) eaav9053 2019年5月

Ultrahigh‐Field MR‐Compatible Mechanical Tactile Stimulator for Investigating Somatosensory Processing in Small‐Bodied Animals 査読

Chenyu Wang, Hirohiko Imai, Masaki Fukunaga, Hiroki Yamamoto, Yinghua Yu, Kazuhiko Seki, Takashi Hanakawa, Tatsuya Umeda, Jiajia Yang

NMR in Biomedicine 38 ( 9 ) 2025年7月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Wiley

ABSTRACT

Common marmosets (Callithrix jacchus), small‐bodied New World primates that share similar sensory processing pathways with human beings, have gained great interests. Their small body size allows imaging of brain activity with high spatial resolution and on a whole‐brain scale using ultrahigh‐field (UHF) magnetic resonance imaging (MRI) scanners. However, the strong magnetic field and the small size of the hand and forearm pose challenges in delivering tactile stimulation during fMRI experiments. In the present study, we developed an MR‐compatible tactile dual‐point stimulator to provide high‐precision mechanical stimulation for exploring somatosensory processing in small‐bodied animals. The study population consisted of a water phantom and three male common marmosets. Cerebral blood volume (CBV) weighted fMRI data were obtained with a gradient echo (GE), echo‐planar imaging (EPI) sequence at 7T scanner. The output performance of the device was tested by a pressure sensor. The MR compatibility of the device was verified by measuring the temporal signal‐to‐noise ratio (tSNR) of a water phantom. To test the effectiveness of tactile stimulation, we conducted block designed tactile stimulation experiments on marmosets. A one‐way repeated measures ANOVA was conducted for comparing the tSNR results. We performed one‐sample t‐tests to investigate the negative response of the forearm and hand stimulation with a threshold of t > 1.96 (p < 0.05). Performance tests revealed that mechanical stimulation (averaged force: 31.69 g) was applied with a delay of 12 ms. Phantom experiments confirmed that there was no significant difference in the tSNR among three (10 Hz, 1 Hz, and no‐stimulus) conditions (F (2, 798) = 0.71, p = 0.49). The CBV activity results showed that the stimulator successfully elicited hand and forearm somatosensory activations in primary somatosensory areas. These results indicated that the device is well suited for small‐bodied animal somatosensory studies.

DOI： 10.1002/nbm.70105

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Contralateral Hand and Foot Know the Time Better: Advantages in Temporal Order Judgment and Their Processing Stages 査読

Zimo Li, Luyao Wang, Shintaro Funahashi, Jinglong Wu, Jiajia Yang, Zhilin Zhang

Journal of Cognitive Neuroscience 1 - 16 2025年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：MIT Press

Abstract

In real-world scenarios, coordination between the contralateral hand and foot is often required to accomplish basic motor tasks, such as walking or running. Research on active movement has shown that the contralateral hand and foot perform better than the ipsilateral hand and foot in terms of interlimb coordination. However, whether this contralateral advantage extends to passive temporal perception remains unknown. In this study, the contralateral advantage was investigated via a temporal order judgment task using ERP technology. The participants received two sequential tactile stimuli on one hand and one foot and determined whether the sequence was “hand before foot” or “foot before hand.” The behavioral results revealed a contralateral advantage in temporal order judgment. Responses to stimuli on the contralateral hand and foot had greater accuracy rates, faster RTs, and smaller just-noticeable differences. The advantage of RTs was modulated by crossing the limbs but remained intact for right-hand responses. The ERP results exhibited a similar pattern, with earlier centroparietal positivity latency and reduced centroparietal positivity and P1 peaks for the contralateral hand and foot combinations. The results indicate a temporal judgment advantage for contralateral hand and foot combinations in both the early and late stages of temporal processing. These findings elucidated the behavioral and neural mechanisms underlying the superior interlimb coordination observed for the contralateral hand and foot combination, with implications for future research to improve the treatment of movement disorders in patient populations.

DOI： 10.1162/jocn_a_02340

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Brain network alterations in mobile phone use problem severity: A multimodal neuroimaging analysis

Lichang Yao, Keigo Hikida, Yinping Lu, Luyao Wang, Qi Dai, Morio Aki, Mami Shibata, Halwa Zakia, Jiajia Yang, Naoya Oishi, Shisei Tei, Toshiya Murai, Zhilin Zhang, Hironobu Fujiwara

Journal of Behavioral Addictions 2025年3月

掲載種別：研究論文（学術雑誌）出版者・発行元：Akademiai Kiado Zrt.

Abstract

Background and aims

Problematic mobile phone use can disrupt social interaction and well-being, potentially influencing cognitive processes. This study investigated whether mobile phone use problem severity is associated with alterations in the topological organization of brain networks.

Methods

Rs-fMRI and DTI data were collected from 81 healthy participants. Graph theory analyses were applied. The Mobile Phone Problem Use Scale-10 (MPPUS-10) was used to assess mobile phone use problem severity. Correlation analyses were conducted between each graph metric and questionnaire scores.

Results

MPPUS-10 scores correlated with global fMRI metrics: higher scores linked to longer shortest path length (reduced integration) and lower global efficiency (reduced information transfer). Conversely, higher MPPUS-10 scores were correlated with a greater clustering coefficient and higher local efficiency, which reflect increased local connectivity. Furthermore, higher MPPUS-10 scores were associated with a higher sigma value from DTI, indicating altered structural network properties. Some specific brain regions also showed significant correlations with MPPUS-10 scores.

Discussion and conclusion

These findings indicate that higher mobile phone use problem severity is associated with decreased integration and increased segregation of functional networks, alongside enhanced small-worldness in structural networks. Reduced integration aligns with addiction theories suggesting digital overload worsens network dysfunction, disrupting brain connectivity. Additionally, higher severity was correlated with altered connectivity in multiple regions, such as the precentral gyrus, supplementary motor area, and postcentral gyrus. These regions are associated with motor control, sensorimotor processing, and memory function. Further research is needed to explore whether these findings reflect shifts in the integration and integrity of brain information-processing modules.

DOI： 10.1556/2006.2025.00021

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その他リンク： https://akjournals.com/downloadpdf/journals/2006/aop/article-10.1556-2006.2025.00021/article-10.1556-2006.2025.00021.xml

Audiovisual integration facilitates age-related perceptual decision-making 査読

Xiangfu Yang, Weiping Yang, Ruizhi Li, Jinfei Lin, Jiajia Yang, Yanna Ren

The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences 2025年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford University Press (OUP)

Abstract

Objectives

Aging populations commonly experience a decline in sensory functions, which negatively affects perceptual decision-making. The decline in sensory functions has been shown to be partially compensated by audiovisual integration. Although audiovisual integration may have a positive effect on perception, it remains unclear whether the perceptual improvements observed in older adults during perceptual decision-making are better explained by the early or late integration hypothesis.

Methods

An audiovisual categorization task was used to explore responses to unisensory and audiovisual stimuli in young and older adults. Behavioral drift diffusion model (DDM) and electroencephalography (EEG) were applied to characterize differences in cognitive and neural dynamics across groups.

Results

The DDM showed that older adults exhibited higher drift rates and shorter non-decision times for audiovisual stimuli than for visual or auditory stimuli alone. The EEG results showed that during the early sensory encoding stage (150 to 300 ms), older adults exhibited greater audiovisual integration in beta-band than younger adults. In the late decision formation stage (500 to 700 ms), older adults exhibited greater audiovisual integration in beta-band and greater audiovisual integration in the anterior frontal electrodes than younger adults.

Discussion

These findings highlight the crucial role of audiovisual integration in both the early and late stages of perceptual decision-making in older adults. The results suggest that enhanced audiovisual integration in older adults compared with younger adults may serve as a specific mechanism to mitigate the negative effects of aging on perceptual decision-making.

DOI： 10.1093/geronb/gbaf037

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Weaker top-down cognitive control and stronger bottom-up signaling transmission as a pathogenesis of schizophrenia 査読

Xiaodan Lyu, Tiantian Liu, Yunxiao Ma, Li Wang, Jinglong Wu, Tianyi Yan, Miaomiao Liu, Jiajia Yang

Schizophrenia 11 ( 1 ) 2025年2月

Beyond facilitating unisensory processing: Crossmodal associative memory training further modulates sensory integration 査読

Zimo Li, Weiping Yang, Ruizhi Li, Rui Luo, Jiajia Yang, Yanna Ren

Biological Psychology 195 108995 - 108995 2025年2月

The role of sleep quality in mediating the relationship between habenula volume and resilience

Qi Dai, Yusuke Kyuragi, Halwa Zakia, Naoya Oishi, Lichang Yao, Morio Aki, Mami Shibata, Zhilin Zhang, Luyao Wang, Jiajia Yang, Toshiya Murai, Hironobu Fujiwara

Psychiatry Research 344 116358 - 116358 2025年2月

Electrophysiological evidence for the effect of tactile temporal prediction 査読

Rongxia Ren, Yinghua Yu, Xiaoyu Tang, Shinnosuke Suzumura, Yoshimichi Ejima, Jinglong Wu, Jiajia Yang

Neuropsychologia 210 109095 - 109095 2025年2月

The Impact of Task Context on Pleasantness and Softness Estimations: A Study Based on Three Touch Strategies

Binyue Gao, Yinghua Yu, Yoshimichi Ejima, Jinglong Wu, Jiajia Yang

Behavioral Sciences 15 ( 1 ) 63 - 63 2025年1月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：MDPI AG

This study investigated the two distinct perceptions (pleasantness and softness) of deformable stimuli with different degrees of compliance under conditions with and without a contextual task. Three tactile strategies—grasping, pinching, and pressing—were used to perceive the stimuli. In Experiment 1 (without a contextual task), participants estimated the perceived intensity of softness or pleasantness for each stimulus. In Experiment 2 (with a contextual task), the participants sequentially perceived two stimuli with different compliance levels and indicated which stimulus they perceived as softer and pleasant. The results showed that the psychophysical relationship between compliance and perceived softness was consistent across all tactile strategies in both experiments, with softness estimates increasing as compliance increased. However, the relationship between compliance and pleasantness differed between the two experiments. In Experiment 1, pleasantness estimates increased monotonically with increased compliance. However, in Experiment 2, across all tactile strategies, pleasantness began to decrease within the compliance range of 0.25–2.0 cm2/N, exhibiting an inverted U-shaped trend. These findings indicate that the relationship between compliance and pleasantness is task-dependent, particularly demonstrating significantly different trends when a contextual task is introduced. In contrast, the relationship between compliance and softness remained consistently monotonic.

DOI： 10.3390/bs15010063

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The Impact of Selective Spatial Attention on Auditory–Tactile Integration: An Event-Related Potential Study 査読

Weichao An, Nan Zhang, Shengnan Li, Yinghua Yu, Jinglong Wu, Jiajia Yang

Brain Sciences 14 ( 12 ) 1258 - 1258 2024年12月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：MDPI AG

Background: Auditory–tactile integration is an important research area in multisensory integration. Especially in special environments (e.g., traffic noise and complex work environments), auditory–tactile integration is crucial for human response and decision making. We investigated the influence of attention on the temporal course and spatial distribution of auditory–tactile integration. Methods: Participants received auditory stimuli alone, tactile stimuli alone, and simultaneous auditory and tactile stimuli, which were randomly presented on the left or right side. For each block, participants attended to all stimuli on the designated side and detected uncommon target stimuli while ignoring all stimuli on the other side. Event-related potentials (ERPs) were recorded via 64 scalp electrodes. Integration was quantified by comparing the response to the combined stimulus to the sum of the responses to the auditory and tactile stimuli presented separately. Results: The results demonstrated that compared to the unattended condition, integration occurred earlier and involved more brain regions in the attended condition when the stimulus was presented in the left hemispace. The unattended condition involved a more extensive range of brain regions and occurred earlier than the attended condition when the stimulus was presented in the right hemispace. Conclusions: Attention can modulate auditory–tactile integration and show systematic differences between the left and right hemispaces. These findings contribute to the understanding of the mechanisms of auditory–tactile information processing in the human brain.

DOI： 10.3390/brainsci14121258

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