2021/08/13 更新

写真a

マツオ トシヒコ
松尾 俊彦
MATSUO Toshihiko
所属
ヘルスシステム統合科学学域 教授
職名
教授
プロフィール
網膜硝子体手術、ぶどう膜炎(全身疾患)、小児眼科、眼腫瘍を専門領域として診療する眼科専門医です。研究は、光電変換色素結合薄膜型の人工網膜(OUReP)の開発研究、斜視の分子遺伝学、トレハロース点眼薬の開発が主要テーマです。人工網膜開発では、2013年からPMDAと戦略相談を繰り返し医師主導治験を準備しています。斜視の分子遺伝学では、全染色体マッピング、SNP解析を行い、遺伝統計学の手法を使って斜視関連遺伝子を特定しています。トレハロース点眼薬は一般薬としてフランスの製薬会社Theaからヨーロッパ市場で販売されています。
外部リンク

学位

  • 医学博士

研究キーワード

  • vitreoretinal diseases

  • vitrectomy (vitreous surgery)

  • molecular genetics (strabismus)

  • uveitis

  • trehalose

  • retinal prosthesis

  • ophthalmic tumors (neoplasms) and pathology

  • pediatric ophthalmology

  • 硝子体手術

  • ぶどう膜炎

  • 網膜硝子体疾患

  • 人工網膜

  • 分子遺伝学

  • 小児眼科

  • トレハロース

  • 眼腫瘍

研究分野

  • ライフサイエンス / 眼科学

学歴

  • 岡山大学   Graduate School, Division of Medicine  

    - 1989年

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  • 岡山大学    

    - 1989年

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    国名: 日本国

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  • 岡山大学   Faculty of Medicine  

    - 1985年

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  • 岡山大学   医学部   医学科

    - 1985年

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    国名: 日本国

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経歴

  • - Associate Professor,Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama University

    2004年

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  • - 岡山大学医歯薬学総合研究科 准教授

    2004年

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  • University of British Columbia, Vancouver, Canada 博士研究員

    1992年 - 1994年

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  • Postdoctoral fellow (Medical Research Council of Canada),University of British Columbia, Vancouver, Canada

    1992年 - 1994年

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  • University of British Columbia, Vancouver, Canada 博士研究員

    1990年 - 1991年

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  • Postdoctoral fellow (Medical Research Council of Canada),University of British Columbia, Vancouver, Canada

    1990年 - 1991年

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  • - Educational Commission for Foreign Medical Graduates (ECFMG) 外国人医師用のアメリカ医師免許

    1986年

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所属学協会

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委員歴

  • 日本人工臓器学会   評議員  

    2015年 - 現在   

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    団体区分:学協会

    日本人工臓器学会

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  • 日本再生医療学会   再生医療認定医  

    2014年 - 現在   

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    団体区分:学協会

    日本再生医療学会

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  • 日本弱視斜視学会   弱視・斜視を専門とする医師 (学会ホームページ掲載)  

    2013年 - 現在   

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    団体区分:学協会

    日本弱視斜視学会

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  • 日本小児眼科学会   小児眼科を専門とする医師 (学会ホームページ掲載)  

    2013年 - 現在   

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    団体区分:学協会

    日本小児眼科学会

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  • 日本眼科学会   評議員  

    2011年   

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    団体区分:学協会

    日本眼科学会

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  • 日本弱視斜視学会   理事  

    2010年 - 2013年   

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    団体区分:学協会

    日本弱視斜視学会

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  • 日本ドライアイ研究会   ドライアイ診療に詳しい医師 (学会ホームページ掲載)  

    2010年   

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    団体区分:学協会

    日本ドライアイ研究会

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  • 日本眼科学会   評議員  

    2003年   

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    団体区分:学協会

    日本眼科学会

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  • 日本眼炎症学会   理事  

    1997年 - 2003年   

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    団体区分:学協会

    日本眼炎症学会

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論文

  • Accuracy of deep learning algorithms for the diagnosis of retinopathy of prematurity by fundus images: systematic review and meta-analysis. 査読

    Jingjing Zhang, Yangyang Liu, Toshiharu Mitsuhashi, Toshihiko Matsuo

    Journal of Ophthalmology   2021 ( 8883946 )   1 - 11   2021年8月

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    担当区分:最終著者   記述言語:英語  

    添付ファイル: ZhangJingjing ROP2021 J Ophthalmol.pdf

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  • Accuracy of deep learning algorithms for the diagnosis of retinopathy of prematurity by fundus images: systematic review and meta-analysis. 査読

    Jingjing Zhang, Yangyang Liu, Toshiharu Mitsuhashi, Toshihiko Matsuo

    Journal of Ophthalmology   2021 ( 8883946 )   1 - 11   2021年8月

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    担当区分:最終著者   記述言語:英語  

    添付ファイル: ZhangJingjing ROP2021 J Ophthalmol.pdf

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  • Alcohol Consumption and Age related Macular Degeneration: A Systematic Review and Dose response Meta analysis. 査読

    Jingjing Zhang, Toshiharu Mitsuhashi, Toshihiko Matsuo, Takashi Yorifuji, Jun Hamada, Yangyang Liu

    Current Eye Research   2021年7月

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  • The effect of cyanine dye NK-4 on photoreceptor degeneration in a rat model of early-stage retinitis pigmentosa. 査読

    Shihui Liu, Toshihiko Matsuo, Mary Miyaji, Osamu Hosoya

    Pharmaceuticals   14 ( 694 )   1 - 14   2021年7月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)  

    添付ファイル: pharmaceuticals-14-00694-v3.pdf

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  • The effect of cyanine dye NK-4 on photoreceptor degeneration in a rat model of early-stage retinitis pigmentosa. 査読

    Shihui Liu, Toshihiko Matsuo, Mary Miyaji, Osamu Hosoya

    Pharmaceuticals   14 ( 694 )   1 - 14   2021年7月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)  

    添付ファイル: pharmaceuticals-14-00694-v3.pdf

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  • Photoelectric dye, NK-5962, as a potential drug for preventing retinal neurons from apoptosis: pharmacokinetic studies based on review of the evidence 査読

    Matsuo T, Liu S, Uchida T, Onoue S, Nakagawa S, Ishii M, Kanamitsu K

    life   11 ( 591 )   1 - 19   2021年6月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    添付ファイル: life-11-00591.pdf

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  • Prostate cancer detected by choroidal tumor and complete response to hormonal therapy: Case report and literature review of 24 patients with choroidal metastasis from prostate cancer. 査読

    Matsuo T, Tanaka T, Nakamura A, Wada K

    Journal of Investigative Medicine High Impact Case Reports   9 ( 23247096211026471 )   1 - 8   2021年6月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    添付ファイル: Prostate Ca2021.pdf

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  • Development and chemical properties of retinal prostheses using photoelectric dyes coupled to polyethylene films with various anions to achieve high durability. 査読

    Yamashita K, Tanaka T, Matsuo T, Uchida T

    Polymer Journal   53   719 - 729   2021年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    添付ファイル: PJ2021OUReP.pdf

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  • Modelling the visual response to an OUReP retinal prosthesis with photoelectric dye coupled to polyethylene film. 査読

    Koichiro Yamashita, Prathima Sundaram, Tetsuya Uchida, Toshihiko Matsuo, Willy Wong

    Journal of Neural Engineering   18 ( 045006 )   1 - 14   2021年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    添付ファイル: J Neural Eng2021.pdf

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  • Development of highly durable retinal prosthesis using photolectric dyes coupled to polyethylene film and quantitative in vitro evaluation of its durability. 査読

    Yamashita K, Tanaka T, Matsuo T, Uchida T

    Biomedical Materials   16 ( 4 )   045001   2021年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    添付ファイル: bmm_16_4_045001.pdf

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  • Television-watching in the early years of life and the association with parents’ concerns about decreased visual acuity in their elementary school-aged child: results of a nationwide population-based longitudinal survey of Japan. 査読

    Matsuo T, Yorifuji T

    Japanese Journal of Ophthalmology   65   561 - 568   2021年3月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    添付ファイル: JJO 21st century final202106.pdf

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  • Follow-up with serum IgG4-monitoring in 8 patients with IgG4-related disease diagnosed by a lacrimal gland mass. 査読

    Matsuo T, Tanaka T, Sato Y, Kataoka H, Uka M, Ennishi D, Yano T

    Journal of Clinical and Experimental Hematopathology   61 ( 1 )   10 - 21   2021年3月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    添付ファイル: JCEH IgG42021.pdf

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  • 「2-12. 人工網膜」テクノロジー・ロードマップ2021-2030 医療・健康・食農編 招待

    松尾俊彦, 内田哲也

    テクノロジー・ロードマップ2021-2030 医療・健康・食農編 日経BP   226 - 229   2021年2月

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    担当区分:筆頭著者   記述言語:日本語  

    添付ファイル: 人工網膜TechnologyRoadMap2021-30.pdf

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  • Photoelectric dye-based retinal prosthesis (OUReP) as a novel type of artificial retina 招待 査読

    Toshihiko Matsuo, Tetsuya Unchida

    Internal Medicine Review   7 ( 1(916) )   1 - 17   2021年1月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    添付ファイル: 916-Photoelectric dye-based retinal prosthesis (1).pdf

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  • Pathologically-proven intraocular infiltration with adult T-cell leukemia/lymphoma: two new cases with either vitreous opacity or aqueous hypopyon and literature review of 16 cases. 査読

    Matsuo T, Shimizu T, Tanaka T, Yamamoto A, Takasuka H

    Journal of Investigative Medicine High Inpact Case Reports   8   1 - 8   2020年10月

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    担当区分:筆頭著者   掲載種別:研究論文(研究会,シンポジウム資料等)  

    添付ファイル: ATL eye J Invest Med HIgh Inpact Case Rep2020.pdf

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  • Curved-Tip Disposable Injector (OUReP Injector) to Insert Photoelectric Dye-Coupled Polyethylene Film (OUReP) as Retinal Prosthesis into Subretinal Space of Rabbit Eyes. 査読

    Toshihiko Matsuo, Chie Matsuo, Tetsuya Uchida, Koichiro Yamashita, Tenu Tanaka, Yusuke Kawakami, Toshiya Hitomi, Kanji Taga, Tatsuya Sanada, Yusuke Yamashita

    Journal of Surgical Techniques and Procedures   4 ( 1040 )   1 - 6   2020年9月

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    担当区分:筆頭著者   掲載種別:研究論文(学術雑誌)  

    添付ファイル: jstp-v4-id1040 final20201003.pdf

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  • Long-term control of macular edema with adalimumab after cataract surgery in a Japanese child with juvenile idiopathic arthritis: case report and review of 26 Japanese patients. 査読

    Toshihiko Matsuo, Masato Yashiro

    Journal of Investigative Medicine High Inpact Case Reports   8   1 - 10   2020年8月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)  

    添付ファイル: JIA case J InvestMed High Impact Case Rep2020.pdf

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  • Step-by-Step Procedure to Test Photoelectric Dye-Coupled Polyethylene Film as Retinal Prosthesis to Induce Light-Evoked Spikes in Isolated Retinal Dystrophic Tissue of rd1 Mice. 査読

    Matsuo T, Terada K, Sakurai M, Liu S, Yamashita K, Uchida T

    Clinics in Surgery   5 ( 2903 )   1 - 9   2020年8月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    添付ファイル: cis-v5-id2903final20200905.pdf

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  • Interview オール岡山の技術が光を取り戻す!-いよいよ最終段階に来た人工網膜とは 招待

    松尾俊彦, 内田哲也

    Optronics   463   124 - 129   2020年7月

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    担当区分:筆頭著者  

    添付ファイル: optronics202007人工網膜.pdf

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  • Superior conjunctiva-sparing intraocular lens-suturing technique with straight long suture needles advanced from the opposite side. 査読

    Toshihiko Matsuo

    Clinics in Surgery   5 ( 2847 )   1 - 5   2020年6月

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    担当区分:筆頭著者  

    添付ファイル: cis-v5-id2847final20200905.pdf

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  • The timing for diagnosis of anisometropia in Japanese children with congenital eyelid ptosis. 査読

    Toshihiko Matsuo

    Clinics in Surgery   5 ( 2842 )   1 - 3   2020年6月

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    担当区分:筆頭著者   掲載種別:研究論文(学術雑誌)  

    添付ファイル: cis-v5-id2842 final20200630.pdf

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  • 特集:人工視覚の現状と展望 「色素結合薄膜型の人工網膜OUReP(オーレップ)」 招待

    松尾俊彦, 内田哲也

    光アライアンス   31 ( 7 )   13 - 18   2020年

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    担当区分:筆頭著者  

    添付ファイル: 光アライアンス2020;31(7)人工網膜.pdf

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  • Are there primary intraocular lymphomas that do not develop into central nervous system lymphomas? 査読

    Matsuo T, Tanaka T

    Journal of Clinical and Experimental hematopathology   59 ( 4 )   168 - 174   2019年12月

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    担当区分:筆頭著者  

    添付ファイル: JCEH2019final intraocular lymphma.pdf

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  • Lacrimal Sac Malignant Melanoma in 15 Japanese Patients: Case Report and Literature Review. 査読

    Matsuo T, Tanaka T, Yamasaki O

    Journal of investigative medicine high impact case reports   7   2324709619888052   2019年1月

  • Long-term outcome in 7 patients with idiopathic orbital myositis. 査読

    Matsuo T

    Japanese Clinical Medicine   10   1 - 5   2019年

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  • Vision evaluation by functional observational battery, operant behavior test, and light/dark box test in retinal dystrophic RCS rats versus normal rats. 査読

    Matsuo T, Uchida T, Yamashita K, Takei S, Ido D, Fujiwara A, Iino M, Oguchi M

    Heliyon   5 ( e01936 )   2019年

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    担当区分:筆頭著者  

    添付ファイル: Heliyon2019 RCSrat.pdf

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  • Photoelectric dye-coupled polyethylene film: photoresponsive properties evaluated by Kelvin probe and in vitro biological response detected in dystrophic retinal tissue of rats. 査読

    Matsuo T, Sakurai M, Terada K, Uchida T, Yamashita K, Tanaka T, Takarabe K

    Advanced Biomedical Engineering   8   137 - 144   2019年

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    担当区分:筆頭著者  

    添付ファイル: ABE2019 OUReP.pdf

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  • Visual Evoked Potential Recovery by Subretinal Implantation of Photoelectric Dye-Coupled Thin Film Retinal Prosthesis in Monkey Eyes With Macular Degeneration. 査読

    Matsuo T, Uchida T, Sakurai J, Yamashita K, Matsuo C, Araki T, Yamashita Y, Kamikawa K

    Artificial organs   42 ( 8 )   E186 - E203   2018年8月

  • Visual evoked potential in rabbits’ eyes with subretinal implantation by vitrectomy of Okayama university-type retinal prosthesis (OURePTM) 査読

    Toshihiko Matsuo, Tetsuya Uchida, Koichiro Yamashita, Shigiko Takei, Daisuke Ido, Mamoru Tanaka, Masao Oguchi, Toshinori Furukawa

    Journal of Veterinary Medical Science   80 ( 2 )   247 - 259   2018年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Japanese Society of Veterinary Science  

    Okayama University-type retinal prosthesis (OURePTM) is a photoelectric dye-coupled polyethylene film which generates electric potential in response to light and stimulates nearby neurons. This study aims to test surgical feasibility for subretinal film implantation and to examine functional durability of films in subretinal space. Dye-coupled films were implanted subretinally by vitrectomy in the right eye of normal white rabbits: 8 rabbits for 1 month and 8 rabbits for 6 months. The implanted films were removed by vitrectomy in 4 of these 8 rabbits in 1-month or 6-month implantation group. The films were also implanted in 4 rhodopsin-transgenic retinal dystrophic rabbits. Visual evoked potential was measured before film implantation as well as 1 or 6 months after film implantation, or 1 month after film removal. The films were successfully implanted in subretinal space of retinal detachment induced by subretinal fluid injection with a 38G polyimide tip. The retina was reattached by fluid-air exchange in vitreous cavity, retinal laser coagulation, and silicone oil injection. The ratios of P2 amplitudes of visual evoked potential in the implanted right eye over control left eye did not show significant changes between pre-implantation and post-implantation or post-removal (paired t-test). In Kelvin probe measurements, 4 pieces each of removed films which were implanted for 1 or 6 months showed proportional increase of surface electric potential in response to increasing light intensity. The film implantation was safe and implanted films were capable of responding to light.

    添付ファイル: JVMS2018 rabbit OUReP.pdf

    DOI: 10.1292/jvms.17-0422

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  • MGST2 and WNT2 are candidate genes for comitant strabismus susceptibility in Japanese patients 査読

    Jingjing Zhang, Toshihiko Matsuo

    PEERJ   5 ( e3935 )   e3935   2017年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PEERJ INC  

    Background/Aim, Strabismus is a common condition with misalignment between two eyes that may lead to decrease of visual acuity, lack of binocularity, and diplopia, It is caused by heterogeneous environmental and genetic risk factors. Our previous research has identified new chromosomal susceptibility loci in 4q28.3 and 7831,2 regions for comitant strabismus in Japanese families, We conducted a verification study by linkage analysis to narrow the chromosomal loci down to a single gene,
    Methods. From Japanese and U.S,databases, 24 rsSNPs and 233 rsSNPs were chosen from the 4828,3 and 7831.2 region, respectively, and were typed in 108 affected subjects and 96 unaffected subjects of 58 families with primary and non-syndromic comitant strabismus. Three major analytical methods were used: transmission disequilibrium test (TDT), TDT allowing for errors (TDTae), and linkage analysis under dominant and recessive inheritance.
    Results. The SNPs with significant P values in TDT and TDTae were located solely at the gene, microsomal glutathione S-transferase 2 (MGST2), on chromosome 4q28.3 locus. In contrast, significant SNPs were dispersed in a few genes, containing wingless-type MMTV integration site family member 2 ( WNT2), on chromosome 7q31.2 locus. The distribution of significant SNPs on the 7q31.2 locus showed that only the ST7 to WNT2 region in the same big haplotype block contained significant SNPs for all three methods of linkage analysis.
    Conclusions. This study suggests that MG ST2 and WNT2 are potential candidates for comitant strabismus in Japanese population.

    添付ファイル: Strabismus SNP PeerJ.pdf

    DOI: 10.7717/peerj.3935

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  • Visual evoked potential in RCS rats with Okayama University-type retinal prosthesis (OUReP™) implantation. 査読

    Alamusi, Matsuo T, Hosoya O, Uchida T

    Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs   20 ( 2 )   158 - 165   2017年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    添付ファイル: Alamusi RCSrat VEP 2017-JAO.pdf

    DOI: 10.1007/s10047-016-0943-4

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  • Vogt-Koyanagi-Harada disease-like posterior uveitis in the course of nivolumab (anti-PD-1 antibody), interposed by vemurafenib (BRAF inhibitor), for metastatic cutaneous malignant melanoma. 査読

    Matsuo T, Yamasaki O

    Clinical case reports   5 ( 5 )   694 - 700   2017年5月

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  • Photoelectric Dye Used for Okayama University-Type Retinal Prosthesis Reduces the Apoptosis of Photoreceptor Cells 査読

    Shihui Liu, Toshihiko Matsuo, Osamu Hosoya, Tetsuya Uchida

    JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS   33 ( 3 )   149 - 160   2017年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MARY ANN LIEBERT, INC  

    Purpose: Our previous study demonstrated that photoelectric dye-coupled polyethylene film (Okayama University-type retinal prosthesis), which was implanted in subretinal space of the eyes of Royal College of Surgeons (RCS) rats, prevented retinal neurons from apoptotic death. In this study, we aimed to examine whether photoelectric dye itself would protect retinal neurons from apoptosis in RCS rats.
    Methods: RCS rats received intravitreous injection of different concentrations of the dye in the left eye and housed under a 12-h light-dark cycle. Saline injection in the right eye served as control. In addition, RCS rats with dye injection were kept in 24-h daily dark condition. Sections were processed for terminal deoxynucleotidyl transferase-mediated fluorescein-conjugated-dUTP nick-end-labeling (TUNEL) assay and immunohistochemical staining of glial fibrillary acidic protein (GFAP) and protein kinase C alpha (PKC alpha).
    Results: The number of TUNEL-positive cells significantly decreased in the retina of dye-injected eyes compared with those in saline-injected eyes (P = 0.0001, 2-factor analysis of variance [ANOVA]), under 12-h light-dark cycle. Significant decrease of TUNEL-positive cells was noted in the retina of rats with dye injection compared with those with saline injection, kept under 24-h dark condition (P = 0.0001, 2-factor ANOVA). Immunoreactive area for GFAP decreased significantly in the retina of dye-injected eyes compared with that in controls (P = 0.0001, 2-factor ANOVA), whereas immunoreactive area for PKCa increased significantly in the retina of dye-injected eyes compared with that in controls (P = 0.01, 2-factor ANOVA).
    Conclusions: Photoelectric dye inhibits apoptotic death of photoreceptor cells in RCS rats and downregulates GFAP expression in retinal Muller cells. Photoelectric dye may be a candidate agent for neuroprotection in retinitis pigmentosa and other retinal diseases.

    添付ファイル: Liu NK5962 final jop.2016.0093.pdf

    DOI: 10.1089/jop.016.0093

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  • Positive bacterial culture in conjunctival sac before cataract surgery with night stay is related to diabetes mellitus 査読

    Tetsuhiro Kawata, Toshihiko Matsuo

    BMC OPHTHALMOLOGY   17 ( 1 )   14   2017年2月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BIOMED CENTRAL LTD  

    Background: The aim of this study is to elucidate background clinical factors in patients with positive bacterial culture for the conjunctival sac before cataract surgery in Japan.
    Methods: Retrospective review was made on medical records of 576 consecutive patients who underwent conjunctival sac culture before cataract surgery with night stay at a hospital in 2 years from January 2013 to December 2014. In the patients with sequential bilateral surgeries, the data were chosen for bacterial culture in the eye which had earlier surgery. The age at surgery ranged from 33 to 100 years (mean, 76.7 years). Clinical factors, analyzed in relation with positive or negative bacterial culture, included the sex, the age, the presence of hypertension or diabetes mellitus, history of cancer, and history of hospital-based surgery at other specialties.
    Results: Bacterial culture of the conjunctival sac was positive in 168 patients while negative in 408 patients. In multiple regression analysis, the positive bacterial culture was related with the older age (P = 0.01), the presence of diabetes mellitus (P = 0.004), and the history of hospital-based surgery at other specialties (P = 0.001).
    Conclusions: Elderly patients with diabetes mellitus or previous hospital-based surgeries at other specialties have a higher rate of positive bacterial culture in the conjunctival sac before cataract surgery. This study would provide a hint for identifying patients at risk for carrying bacterial flora in the conjunctival sac.

    添付ファイル: Conj Sac Culture BMC Ophthalmol2017.pdf

    DOI: 10.1186/s12886-017-0413-7

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  • Orbital MALT Lymphoma after Autologous Stem Cell Transplantation for Follicular Lymphoma as Relapse of Diffuse Large B-Cell Lymphoma. 査読

    Matsuo T, Tanaka T, Fujii N

    Journal of clinical and experimental hematopathology : JCEH   56 ( 3 )   170 - 175   2017年

  • Nephrotic syndrome during the tapering of oral steroids after pathological diagnosis of Kimura disease from a lacrimal gland mass: case report and review of 10 Japanese patients. 査読

    Matsuo T, Tanaka T, Kinomura M

    Journal of clinical and experimental hematopathology : JCEH   57 ( 3 )   147 - 152   2017年

  • Subretinal implantation of Okayama university-type retinal prosthesis (OURepTM) in canine eyes by vitrectomy 査読

    Toshihiko Matsuo, Tetsuya Uchida, Makoto Nitta, Koichiro Yamashita, Shigiko Takei, Daisuke Ido, Mamoru Tanaka, Masao Oguchi, Toshinori Furukawa

    Journal of Veterinary Medical Science   79 ( 12 )   1939 - 1946   2017年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Japanese Society of Veterinary Science  

    Okayama University-type retinal prosthesis (OUReP™) is a photoelectric dye-coupled polyethylene film which generates electric potential in response to light and stimulates nearby neurons. This study aims to test surgical feasibility of subretinal implantation and functional durability of dye-coupled films in the subretinal space. The dye-coupled films were implanted subretinally by 25-gauge vitrectomy in the right eye of 11 normal beagle dogs: 2 dogs served for film removal after 5-month film implantation, 3 dogs for film removal after 3-month film implantation, 3 dogs for 3-month film implantation and pathological examination, and 3 dogs for sham surgery. The surface electric potential of the removed dye-coupled films in response to light was measured by the Kelvin Probe system. At surgery, rolled-up dye-coupled films in 5 × 5 mm square size could be inserted into subretinal space of retinal detachment induced by fluid injection with a 38-gauge polyimide tip. Retinal attachment was maintained by silicone oil injection in vitreous cavity. At autopsy, the retina in all dogs maintained the ganglion cell layer, inner and outer nuclear layers while it lost the outer segments in some part. All 5 sheets of removed dye-coupled films maintained the dye color. One sheet of the 5-month implanted film showed proportional increase of surface potential in response to increasing light intensity. Subretinal implantation of OUReP™ by vitrectomy was technically feasible in canine eyes, and OUReP™ maintained the function of generating light-evoked surface potential after 5 months in subretinal implantation.

    添付ファイル: dog surgeryOUReP2017JVMS.pdf

    DOI: 10.1292/jvms.17-0450

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  • Clinical decision upon resection or observation of ocular surface dermoid lesions with the visual axis unaffected in pediatric patients 査読

    Toshihiko Matsuo

    SPRINGERPLUS   4 ( 1 )   534   2015年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER INTERNATIONAL PUBLISHING AG  

    Ocular surface or epibulbar dermoid lesions may present as limbal dermoids at the corneal limbus or dermolipomas in the conjunctival fornix. The purpose of this study is to review clinical features of ocular surface dermoids (grade I), with the visual axis unaffected, in pediatric patients, in order to find key features for making clinical decision, either resection or observation. The study involved 13 consecutive patients with limbal dermoids or fornix dermolipomas which did not affect the visual axis, seen in 11 years at a referral-based institution. Eight patients underwent surgical resection at the age, ranging from 1 to 18 (median, 4) years, with concurrent preauricular appendage resection in 3 patients. Limbal dermoids in 6 patients presented dome-shaped elevation from the ocular surface, and extended in inferotemporal quadrant for 1-2 clock hours. The remaining 2 patients showed dermolipomas in the temporal conjunctival fornix. Postoperative astigmatism at the final visit ranged from 0 to 7 (median, 2.9) diopters in 6 patients with limbal dermoids while ranged from 0 to 1 diopters in 2 patients with fornix dermolipomas. All patients with meaningful astigmatism wore glasses before and after the surgery, resulting in no apparent ametropic or anisometropic amblyopia. Observation was chosen in 5 patients with the age at initial visit, ranging from 0 to 2 (median, 1) years, and the age at the final visit, ranging from 2 to 6 (median, 3) years. Flat limbal dermoids, extending for 1-2 clock hours, were noted in 3 patients, a dome-shaped limbal dermoid for 1 clock hour in one, and a fornix dermolipoma in one. Three patients had preauricular appendages. No patient, except for one with a dome-shaped limbal dermoid, showed astigmatism, greater than one diopter. In conclusions, dome-shaped limbal dermoids were excised while flat limbal dermoids observed. The age at surgery varied largely in pediatric patients with limbal dermoids (grade I) or fornix dermolipomas which did not affect the visual axis. The surgical timing was influenced by surgical scheduling for preauricular appendage resection, determined by a plastic surgeon. Surgical decision was made for cosmetic purposes, but not for medical needs to avoid amblyopia.

    添付ファイル: Dermoid Springerplus.pdf

    DOI: 10.1186/s40064-015-1326-7

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  • Vision maintenance and retinal apoptosis reduction in RCS rats with Okayama University-type retinal prosthesis (OUReP™) implantation. 査読

    Alamusi, Matsuo T, Hosoya O, Tsutsui KM, Uchida T

    Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs   18 ( 3 )   264 - 271   2015年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    添付ファイル: alamusi J Artif Org2015.pdf

    DOI: 10.1007/s10047-015-0825-1

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  • How far is observation allowed in patients with ectopia lentis? 査読

    Toshihiko Matsuo

    SpringerPlus   4   461   2015年8月

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  • Clinical factors underlying a single surgery or repetitive surgeries to treat superior oblique muscle palsy 査読

    Kana Aoba, Toshihiko Matsuo, Ichiro Hamasaki, Kayoko Hasebe

    SPRINGERPLUS   4 ( 166 )   166   2015年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER INTERNATIONAL PUBLISHING AG  

    The purpose of this study is to know clinical factors underlying either a single surgery or repetitive surgeries, required to treat superior oblique muscle palsy. Retrospective review was made on 246 consecutive patients with idiopathic (n = 212) or acquired (n = 34) superior oblique muscle palsy who underwent surgeries in 8 years at one institution. Idiopathic palsy included congenital and decompensated palsies while acquired palsy included traumatic and ischemic palsies. Clinical factors, compared between groups with a single surgery (n = 203) and two or more surgeries (n = 43), were surgical methods, sex, age at surgery, horizontal, vertical, and cyclotorsional deviations, and stereopsis at near fixation. Inferior oblique muscle recession on paretic side was chosen in about 60% of the single-surgery and repetitive-surgery group as an initial surgery, followed by inferior rectus muscle recession on non-paretic side. The age at surgery was significantly older, vertical and cyclotorsional deviations were significantly larger in the repetitive-surgery group, compared with the single-surgery group (P = 0.01, P < 0.001, P = 0.02, Mann-Whitney U-test, respectively). The 95% confidence interval of vertical deviations was 15-17 prism diopters in the single-surgery group and 23-28 prism diopters in the repetitive surgery group. Significant differences in vertical deviations were replicated also in subgroups of patients with either idiopathic or acquired palsy. In conclusions, the 95% confidence interval of vertical deviations, determined by alternate prism and cover test, would be used as a common benchmark for predicting either a single surgery or repetitive surgeries, required to treat idiopathic and acquired superior oblique muscle palsy, in the process of obtaining the informed consent.

    添付ファイル: Aoba2015_Article_ClinicalFactorsUnderlyingASing.pdf

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  • Intraocular Relapse with Hypopyon and Retinal Infiltrates after Chemotherapy and Peripheral Blood Stem Cell Transplantation for Extranodal NK/T-Cell Lymphoma. 査読

    Matsuo T, Tanaka T, Ichimura K, Meguri Y

    Journal of clinical and experimental hematopathology : JCEH   55 ( 3 )   157 - 161   2015年

  • Oral infection control to assist infliximab therapy in a Behçet's disease patient with severe eye inflammation in response to dental treatment: a case report. 査読

    Kudo C, Wakabayashi H, Shimoe M, Kobayashi H, Ito T, Ohkawa T, Isoshima-Nakamura A, Mineshiba J, Yoshioka N, Nawachi K, Maeda H, Matsuo T, Makino H, Takashiba S

    Clinical case reports   2 ( 6 )   274 - 280   2014年12月

  • Mantle cell lymphoma diagnosed by conjunctival salmon-pink lesion biopsy. 査読

    Matsuo T, Ichimura K, Kubonishi S

    Journal of clinical and experimental hematopathology : JCEH   54 ( 2 )   143 - 147   2014年

  • Erratum: Optical coherence tomographic parameters as objective signs for visual acuity in patients with retinitis pigmentosa, future candidates for retinal prostheses (Journal of Artificial Organs (2011) 14, (140-150) DOI: 10.1007/s10047-011-0557-9) 査読

    Miho Tamaki, Toshihiko Matsuo

    Journal of Artificial Organs   14 ( 4 )   385   2011年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Tokyo  

    DOI: 10.1007/s10047-011-0597-1

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  • Optical coherence tomographic parameters as objective signs for visual acuity in patients with retinitis pigmentosa, future candidates for retinal prostheses 査読

    Miho Tamaki, Toshihiko Matsuo

    Journal of Artificial Organs   14 ( 2 )   140 - 150   2011年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Tokyo  

    To find optical coherence tomographic parameters related with visual acuity, and, thus, which might be used as objective signs to predict visual acuity after future treatment, for example retinal prosthesis implantation, 86 eyes of 45 consecutive patients with retinitis pigmentosa, who showed no macular diseases, underwent optical coherence tomography to measure macular retinal thickness and peripapillary retinal nerve fiber layer (RNFL) thickness, and to obtain horizontal cross-sectional images at the fovea for observation of the inner segment/outer segment (IS/OS) junction line. Best-corrected visual acuity was significantly better either in the right eyes or in the left eyes with greater retinal thickness of all four quadrants of the macular area in the inner ring, encompassing 1-3 mm from the foveal center (P\\0.05, Spearman rank correlation test), and also with the presence of the IS/OS line at the fovea (P\\0.0001, Wilcoxon-Kruskal-Wallis rank sum test). Retinal average thickness in the posterior pole covering the 6 9 6 mm square area was positively correlated with peripapillary RNFLaverage thickness either in the right eyes or in the left eyes (P\\0.05). The average thickness of the peripapillary RNFLbecame significantly less with age (P\\0.05), but was not related with visual acuity. Macular retinal thickness and the presence of the IS/OS line, but not peripapillary RNFLthickness, could serve as objective signs for better visual acuity in retinitis pigmentosa. The macular retinal thickness might be used as an objective predictor to choose patients with retinitis pigmentosa who would be expected to gain vision after retinal prosthesis implantation. © The Japanese Society for Artificial Organs 2011.

    DOI: 10.1007/s10047-011-0557-9

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  • Immunoglobulin G4 (IgG4)-positive or -negative ocular adnexal benign lymphoid lesions in relation to systemic involvement. 査読

    Matsuo T, Ichimura K, Sato Y, Tanimoto Y, Kiura K, Kanazawa S, Okada T, Yoshino T

    Journal of clinical and experimental hematopathology : JCEH   50 ( 2 )   129 - 142   2010年

  • Different histopathological types of orbital lymphoma 16 years after systemic follicular lymphoma: immunohistochemical and immunogenetic analyses of two cases. 査読

    Matsuo T, Ichimura K, Shinagawa K, Yoshino T

    Journal of clinical and experimental hematopathology : JCEH   48 ( 1 )   17 - 24   2008年4月

  • Clinical features, ARIX and PHOX2B nucleotide changes in three families with congenital superior oblique muscle palsy 査読

    Sayuri Imai, Toshihiko Matsuo, Emi Itoshima, Hiroshi Ohtsuki

    ACTA MEDICA OKAYAMA   62 ( 1 )   45 - 53   2008年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    We analyzed nucleotide changes in 3 genes, ARIX, PHOX2B, and KIF21A, in 6 patients of 3 families with congenital superior oblique muscle palsy. Three exons of ARIX, 3 exons of PHOX2B, and exons 8, 20, and 21 of KIF21A were amplified by polymerase chain reaction from genomic DNA isolated from the peripheral blood. The DNA fragments were directly sequenced in both directions. In 2 different families, a heterozygous nucleotide change, ARIX 153G > A, in the 5'-untranslated region was found in common between a father and daughter with muscle palsy and between a mother and daughter with muscle palsy (Family No. I and No. 3). In the other family (Family No. 2), a heterozygous 15-nucleotide deletion, PHOX2B 1124del15, resulting in loss of 5 alanine residues in the alanine repeat of the protein, was found in the daughter with muscle palsy and her father with normal traits, but was not found in the mother with muscle palsy. No KIF21A nucleotide change was found in any patients. The ARIX 153G > A polymorphism might be a genetic risk factor for the development of congenital superior oblique muscle palsy.

    DOI: 10.18926/AMO/30985

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  • [Vision engineering--photoelectric dye-based retinal prostheses: Okayama University model]. 査読

    Matsuo T

    Brain and nerve = Shinkei kenkyu no shinpo   59 ( 4 )   331 - 338   2007年4月

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  • Vision engineering - Photoelectric dye-based retinal prostheses: Okayama university model 査読

    Toshihiko Matsuo

    Brain and Nerve   59 ( 4 )   331 - 338   2007年4月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    Patients with retinitis pigmentosa lose photoreceptor cells by genetic abnormalities and hence become blind. Neurons such as bipolar cells and ganglion cells still remain alive even in the retina of these patients, and ganglion cells send axons to the brain as the optic nerve. The replacement of dead photoreceptor cells with something artificial is the basic concept of retinal prostheses. The remaining retinal neurons can be stimulated by either electric current or electric potential. Photodiode array and electrode array are two main ways to stimulate retinal neurons as retinal prostheses. These retinal prostheses have problems such as low sensitivity and requiring outer electric sources (batteries). To overcome the problems, we are developing photoelectric dye-based retinal prostheses which absorb light and convert photon energy to electric potentials. The prototype, photoelectric dye-coupled polyethylene film, could generate intracellular calcium elevation in photoreceptor-lacking retinal tissues and also in cultured retinal neurons. The photoelectric dye-based retinal prostheses are thin and soft, and therefore, a sheet of the film in a large size, corresponding to wide visual field, can be inserted into the vitreous and then to the subretinal space through a small opening by rolling up the film. After the production control and the quality control have been established, clinical trials of the photoelectric dye-based retinal prostheses would be planned in concordance with the Drugs and Medical Devices Law to prove the safety and the efficacy.

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  • Detection of strabismus and amblyopia in 1.5-and 3-year-old children by a preschool vision-screening program in Japan 査読

    Toshihiko Matsuo, Chie Matsuo, Hiroaki Matsuoka, Keiko Kio

    ACTA MEDICA OKAYAMA   61 ( 1 )   9 - 16   2007年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    All children at the age of 1.5 and 3 years in Japan undergo physical, mental, and developmental checkups including dental, eye, and hearing examinations. The vision-screening program consists of 3 steps: questionnaires and home visual acuity testing as the first step (only for 3-year-old children), visual acuity testing by nurses and inspection by medical officers at regional Health Centers as the second step, and detailed examinations by ophthalmologists as the third step. This study aims to reveal the prevalence of strabismus and amblyopia as obtained from data in the vision-screening program. The final diagnoses made by ophthalmologists and sent back to the Health Centers in Okayama City were reviewed to elucidate the prevalence of strabismus, amblyopia, refractive errors, and other diseases in 1.5- and 3-year-old children in Okayama City in 5 years from 2000 to 2004. Of approximately 6,500-6,900 total children, 83.7-86.8% at 1.5 years old and 77.8-81.9% at 3 years old were brought to the Health Centers. The rates of strabismus were 0.01-0.12% at 1.5 years old and 0.20-0.34% at 3 years old, while the rates of amblyopia were 0% at 1.5 years old and 0.13-0.18 % at 3 years old. The higher rates of strabismus at 3 years old were attributed mainly to the increase of exotropia and intermittent exotropia. In conclusions, the prevalence of strabismus was different between 1.5- and 3-year-old children. The vision-screening program in Japan functions to detect strabismus and amblyopia.

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  • Prostaglandins F-2 alpha and E-2 in aqueous humor of patients with cataract surgery 査読

    T Matsuo

    JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS   20 ( 2 )   101 - 106   2004年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MARY ANN LIEBERT INC PUBL  

    To understand the role of prostaglandins F-2alpha, and E-2 in aqueous humor under the normal condition, their concentrations were measured by enzyme immunoassay in aqueous fluid obtained from either eye of 60 patients during cataract surgery and correlated with clinical factors as the age and intraocular pressure. The concentrations of prostaglandin F-2alpha in the aqueous of all patients were below the level of detection. The concentrations of prostaglandin E-2 in the aqueous were below the level of detection in 37 patients while ranged from 9 to 48 pg/mL (median, 31) in 23 patients. The levels of prostaglandin E-2 did not have correlation with the age of the patients or the intraocular pressure of the eyes. In conclusions, the concentrations of prostaglandin E-2 were apparently higher than the concentrations of prostaglandin F-2alpha in the aqueous. This study could not prove the relationship between prostaglandin levels and the intraocular pressure or the age.

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  • ARIX gene polymorphisms in patients with congenital superior oblique muscle palsy 査読

    Y Jiang, T Matsuo, H Fujiwara, S Hasebe, H Ohtsuki, T Yasuda

    BRITISH JOURNAL OF OPHTHALMOLOGY   88 ( 2 )   263 - 267   2004年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:B M J PUBLISHING GROUP  

    Aim: To identify ARIX gene polymorphisms in patients with congenital superior oblique muscle palsy and to find the relation between the ARIX gene and congenital superior oblique muscle palsy.
    Methods: The three exons of the ARIX gene were sequenced by genomic DNA amplification with polymerase chain reaction (PCR) and direct sequencing in 15 patients with superior oblique muscle palsy (13 with congenital and two with acquired palsy) and 54 normal individuals. PCR products cloned into plasmids were also sequenced. A family with father and a daughter each having congenital superior oblique muscle palsy was also involved in this study.
    Results: Four patients with congenital superior oblique muscle palsy carried heterozygous nucleotide changes in the ARIX gene. One patient with the absence of the superior oblique muscle had T7C in the 5'-UTR of the exon 1 and C-44A in the promoter region, both of which were located on the same strand. Another unrelated patient with congenital superior oblique muscle palsy had C76G in the 5'-UTR of the exon 1 and C-9A in the promoter region on the same strand. G153A in the 5'-UTR of exon 1 was found in common in two affected members of a family with congenital superior oblique muscle palsy. This G153A in the 5'-UTR of exon 1 was also present in four unrelated normal individuals. No other heterozygous nucleotide changes were found in normal individuals.
    Conclusions: The nucleotide change (G153A) in the 5'-UTR of exon 1 co-segregated with congenital superior oblique muscle palsy in one family. Four other nucleotide changes in the exon 1 or the promoter region were found only in patients with congenital superior oblique muscle palsy. These nucleotide polymorphisms may be one of the risk factors for the development of congenital superior oblique muscle palsy.

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  • A Simple Method for Screening Photoelectric Dyes towards Their Use for Retinal Prostheses 査読

    Toshihiko Matsuo

    Acta Medica Okayama   57 ( 5 )   257 - 260   2003年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Photoelectric dyes absorb light and convert photon energy to electric potentials. To test whether these dyes could be used for retinal prostheses, a simple in vitro screening system was developed. Retinal neurons were cultured from the eyes of chick embryos at the 10-day embryonic stage, at which time no retinal photoreceptor cells have yet developed. Intracellular calcium elevation was observed with Fluo-4 in cultured retinal neurons before and after photoelectric dye was applied at varying concentrations to the culture medium. Five of 7 photoelectric dyes tested in this in vitro system induced intracellular calcium elevation in cultured chick retinal neurons. The intracellular calcium elevation generated by the 5 photoelectric dyes was blocked by extracellular calcium depletion in the case of all 5 dyes, and, except for one dye, by the presence of voltage-gated calcium channel blockers. The photoelectric dyes absorbed light under an inverted microscope and stimulated retinal neurons. This simple in vitro system allows the screening of photoelectric dyes which can be used for retinal prostheses.

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  • Clinical correlations of aggrecan in the resected medial rectus muscle of patients with intermittent exotropia 査読

    T Yamane, T Matsuo, S Hasebe, H Ohtsuki

    ACTA MEDICA OKAYAMA   57 ( 4 )   199 - 204   2003年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    The purpose of this study was to elucidate the role of extracellular matrix components such as aggrecan, fibronectin, and laminin in the extraocular muscle of patients with strabismus. Resected tissues of the medial rectus muscle of 47 patients with intermittent exotropia obtained during recession-resection surgery were frozen under liquid nitrogen and pulverized by a Freezer/Mill to solubilize the tissue for enzyme immunoassay. The total amounts of aggrecan, fibronectin, and laminin in the resected tissue were correlated with clinical data of patients such as age, exodeviation, and refractive error. The amount of aggrecan decreased significantly with the advance of age (P < 0.0001, Spearman rank correlation test), while the amount of laminin or fibronectin had no correlation with age. Patients with basic type intermittent exotropia showed larger, although not significantly, amounts of aggrecan than those with convergence insufficiency type (P = 0.0538, Mann-Whitney U-test). The amount of aggrecan may be related to motor aspects of intermittent exotropia.

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  • Genome-wide search for strabismus susceptibility loci 査読

    H Fujiwara, T Matsuo, M Sato, T Yamane, M Kitada, S Hasebe, H Ohtsuki

    ACTA MEDICA OKAYAMA   57 ( 3 )   109 - 116   2003年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    The purpose of this study was to search for chromosomal susceptibility loci for comitant strabismus. Genomic DNA was isolated from 10 mL blood taken from each member of 30 nuclear families in which 2 or more siblings are affected by either esotropia or exotropia. A genome-wide search was performed with amplification by polymerase chain reaction of 400 markers in microsatellite regions with similar to10 cM resolution. For each locus, non-parametric affected sib-pair analysis and nonparametric linkage analysis for multiple pedigrees (Genehunter software, http://linkage. rockefeller.edu/soft/) were used to calculate multipoint lod scores and non-parametric linkage (NPL) scores, respectively. In sib-pair analysis, lod scores showed basically flat lines with several peaks of 0.25 on all chromosomes. In non-parametric linkage analysis for multiple pedigrees, NPL scores showed one peak as high as 1.34 on chromosomes 1, 2, 4, 7, 10, 15, and 16, while 2 such peaks were found on chromosomes 3, 9, 11, 12, 18, and 20. Non-parametric linkage analysis for multiple pedigrees of 30 families with comitant strabismus suggested a number of chromosomal susceptibility loci. Our ongoing study involving a larger number of families will refine the accuracy of statistical analysis to pinpoint susceptibility loci for comitant strabismus.

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  • Multiple sclerosis-like disease secondary to alpha interferon 査読

    T Matsuo, R Takabatake

    OCULAR IMMUNOLOGY AND INFLAMMATION   10 ( 4 )   299 - 304   2002年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SWETS ZEITLINGER PUBLISHERS  

    Purpose: To describe bilateral optic neuritis that occurred as an adverse effect of recombinant and natural interferon a administration. Methods: Report of two cases. Case 1, a 62-year-old woman, developed bilateral optic neuritis with decreased sensation of vibration and increased deep tendon reflex in the lower extremities after a seven-month use of recombinant interferon alpha-2a for chronic active hepatitis C. Case 2, a 29-year-old woman, developed bilateral optic neuritis combined with numbness of the lower extremities as well as bowel and bladder dysfunction after a 22-month use of recombinant interferon alpha-2b for chronic myelogenous leukemia. After a two-month interruption of interferon administration, natural interferon a was given but followed by another episode of the same neurological manifestations. Results: In both cases, magnetic resonance imaging demonstrated multiple small high-intensity areas in the cerebral white matter and spinal cord, while cerebrospinal fluid examination disclosed mononuclear cell increase and protein elevation including myelin basic protein, all of which simulated the features of multiple sclerosis. The two patients underwent several courses of pulse corticosteroid therapy, each course consisting of three days of methylprednisolone 1000 mg daily, resulting in visual recovery to some extent. Conclusions: Optic neuritis in combination with other neurological signs, simulating multiple sclerosis, should be included in the list of adverse effects of recombinant and natural interferon a administration.

    DOI: 10.1076/ocii.10.4.299.15588

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  • Seropositivity of human herpesvirus-8 in patients with uveitis 査読

    T Matsuo, M Itami

    OCULAR IMMUNOLOGY AND INFLAMMATION   10 ( 3 )   197 - 199   2002年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SWETS ZEITLINGER PUBLISHERS  

    Purpose: To explore the role of human herpesvirus-8 (HHV-8) in the pathogenesis of uveitis and other forms of ocular inflammation. Methods: Serum antibody titers to HHV-8 were measured in 76 patients with uveitis from various causes and other types of ocular inflammation in either the acute phase, the convalescent phase, or both. Results: Only one 21-year-old male patient in the convalescent phase of unilateral pars planitis showed a positive titer for HHV-8. His serum was negative for human immunodeficiency virus-I. Conclusions: Although the seropositive rate in the patient population was higher than that in the general population, the increased incidence was not statistically significant. The role of HHV-8 in the pathogenesis of intraocular inflammation appears to be limited.

    DOI: 10.1076/ocii.10.3.197.15602

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  • Submacular exudates with serous retinal detachment caused by cat scratch disease 査読

    T Matsuo, M Kato

    OCULAR IMMUNOLOGY AND INFLAMMATION   10 ( 2 )   147 - 150   2002年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SWETS ZEITLINGER PUBLISHERS  

    Purpose: To present submacular exudates as a manifestation of cat scratch disease. Methods: Report of two cases. Results: The first patient, a 34-year-old man, developed submacular exudates with serous retinal detachment ten days after having axillary lymphadenopathy and fever. The second patient, a 30-year-old woman, developed submacular exudates with serous retinal detachment mimicking central serous chorioretinopathy. Fluorescein angiography revealed late staining of the subretinal lesions in both cases. The lesion resolved spontaneously in the first patient, while sulfamethoxazole and trimethoprim was required for the second patient. Both patients had a positive IgG titer for Bartonella henselae. Conclusions: Submacular exudates with serous retinal detachment can occur in cat scratch disease. Cat scratch disease should be included in the differential diagnosis of submacular exudates with central serous chorioretinopathy.

    DOI: 10.1076/ocii.10.2.147.13979

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  • The incidence and pathology of conjunctival ulceration in Behçet's syndrome. 査読

    Matsuo T, Itami M, Nakagawa H, Nagayama M

    The British journal of ophthalmology   86 ( 2 )   140 - 143   2002年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • A novel gene (retinovin) expressed selectively in the early stage of chick retinal development 査読

    M Itami, T Matsuo, H Ohtsuki

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   276 ( 1 )   12 - 15   2000年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACADEMIC PRESS INC  

    To understand molecular mechanisms of retinal development, genes expressed selectively only in the early stage of retinal development were isolated by subtractive hybridization based on suppression polymerase chain reaction. The retina has no layered structure in 7-day chick embryos, in contrast with the fully developed multilayered structure of neurons in 15-day embryos. The subtraction between cDNA derived from retinal tissues at these different stages, followed by repeat rounds of 5'-RACE (rapid amplification of cDNA ends) and 3'-RACE, led to isolation of a novel gene with an open reading frame encoding a putative protein with 753 amino acids. Its specific expression in the 7-day embryonic retina was confirmed by Northern blot analysis. The gene, named "retinovin," would be used as a marker for identifying retinal stem cells present at the early stage of retinal development. (C) 2000 Academic Press.

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  • Identification of ingrowth site of idiopathic subfoveal choroidal neovascularization by indocyanine green angiography 査読

    Fumio Shiraga, Chieko Shiragami, Toshihiko Matsuo, Shiho Yokoe, Ippei Takasu, Hiroshi Ohtsuki

    Ophthalmology   107 ( 3 )   600 - 607   2000年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Purpose: This study aimed to determine whether indocyanine green (ICG) angiography is useful to identify the ingrowth site of idiopathic choroidal neovascularization (CNV), which can predict visual outcomes after surgical removal of idiopathic CNV. Design: Consecutive, observational case series. Participants: Twenty-six patients with idiopathic subfoveal CNV, of whom six underwent submacular surgery. Intervention: Indocyanine green videoangiography with a scanning laser ophthalmoscope. Main Outcome Measures: We studied ICG videoangiographic images of choroidal neovascular membranes from the early phase to the late phase with special attention to abnormal findings, which can indicate the ingrowth site of CNV. Results: Early ICG angiography demonstrated distinct neovascular vessels in 24 of the 26 patients (92%). Hypofluorescent rims continuously or intermittently surrounded neovascular membranes on late ICG angiograms in 21 of the 26 patients (81%). In 22 of the 26 patients (85%), ICG angiography demonstrated hypofluorescent areas within the CNV. These hypofluorescent areas frequently became ring shaped in the middle to late phase of the ICG angiography. In 14 of 16 patients (88%) with CNV larger than half a disc area, the filling of neovascular vessels appeared from the inside of the hypofluorescent areas and branched out toward the surrounding hyperfluorescent membrane in the early phase. In all six patients who underwent surgical removal of CNV, ICG videoangiography showed these hypofluorescent areas from which neovascular vessels emanated. Three of the four surgical patients, in whom hypofluorescent areas or central fluorescent areas surrounded by ring-shaped hypofluorescence were extrafoveal or juxtafoveal, had a best postoperative visual acuity of 20/60 or better. In contrast, both surgical patients with subfoveal hypofluorescent areas had a best postoperative visual acuity of 20/70 or worse. Conclusions: Although further observations are needed, ICG angiography may be a useful adjunct in the identification of the ingrowth site of idiopathic CNV, which can predict visual outcomes after surgery. (C) 2000 by the American Academy of Ophthalmology.

    DOI: 10.1016/S0161-6420(99)00126-8

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  • Surgical treatment of submacular hemorrhage associated with idiopathic polypoidal choroidal vasculopathy 査読

    Fumio Shiraga, Toshihiko Matsuo, Shiho Yokoe, Ippei Takasu, Toshio Okanouchi, Hiroshi Ohtsuki, Hans E. Grossniklaus

    American Journal of Ophthalmology   128 ( 2 )   147 - 154   1999年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: To report the visual outcome of surgical treatment of submacular hemorrhage associated with idiopathic polypoidal choroidal vasculopathy. METHODS: Eight eyes of eight consecutive patients with thick submacular hemorrhages associated with idiopathic polypoidal choroidal vasculopathy were treated with pars plana vitrectomy and tissue plasminogen activator-assisted removal of subretinal blood (December 1995 to September 1997) or intravitreal 100% sulfur hexafluoride gas injection without tissue plasminogen activator (October 1997 to March 1998). RESULTS: Postoperatively, laser treatment was performed for active polypoidal lesions outside the foveal avascular zone in four eyes. A retinal pigment epithelial tear was seen outside the foveal avascular zone in three eyes, and one eye developed a retinal detachment. The best-corrected visual acuity improved (by 3 or more lines) or stabilized in seven of the eight eyes. Four eyes had a final best- corrected visual acuity of 20/40 or better, and three eyes had a final best- corrected visual acuity of 20/50 to 20/200. In one eye, the visual acuity decreased from 20/100 to 20/500 because of the development of a subfoveal neovascular membrane. The membrane was excised, and histologic examination showed fibrovascular tissue between the retina and retinal pigment epithelium (type 2 pattern). CONCLUSIONS: Surgical intervention may be of benefit in eyes with submacular hemorrhage associated with idiopathic polypoidal choroidal vasculopathy.

    DOI: 10.1016/S0002-9394(99)00078-1

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  • A novel gene (oculomedin) induced by mechanical stretching in human trabecular cells of the eye 査読

    Yukiko Sato, Toshihiko Matsuo, Hiroshi Ohtsuki

    Biochemical and Biophysical Research Communications   259 ( 2 )   349 - 351   1999年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Academic Press Inc.  

    To understand molecular mechanisms underlying the response to pressure in human trabecular cells of the eye, genes induced by cyclic mechanical stretching were isolated by subtractive hybridization assisted by polymerase chain reaction. A novel gene containing an Alu repetitive element in the 5' untranslated region was identified, and its expression was confirmed by Northern blot analysis to be stretch-specific in trabecular cells. The gene was also expressed in the retina, but not in the other tissues, including the brain. The gene encoded a putative small protein with 44 amino acids, which showed homology with neuromedin K. The putative novel protein was named as 'oculomedin,' and would be used as a candidate gene for glaucoma.

    DOI: 10.1006/bbrc.1999.0797

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  • Aqueous vascular endothelial growth factor increases in anterior segment ischemia in rabbits 査読

    T Tanaka, T Matsuo, H Ohtsuki

    JAPANESE JOURNAL OF OPHTHALMOLOGY   42 ( 2 )   85 - 89   1998年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    Both long posterior ciliary arteries were occluded or the three extraocular muscles were tenotomized to produce anterior segment ischemia in rabbits, and the aqueous levels of vascular endothelial growth factor (VEGF) were measured. The occlusion of both long posterior ciliary arteries led to clinical and histological anterior segment ischemia in varying degrees. The aqueous VEGF levels increased significantly compared with controls on all days examined (Mann-Whitney U test: day 1, P = 0.0039; day 4, P = 0.0065; day 7, P = 0.0039; day 14, P = 0.0104), while the levels at days 7 and 14 decreased significantly compared with those at day 4 (Wilcoxon signed-rank test; day 4 to day 7 and day 4 to day 14, P = 0.0464). In contrast, tenotomy of the three extraocular muscles resulted in no histological changes. The VEGF levels increased significantly compared with controls at day 1 and day 4 after surgery (Mann-Whitney U test: day 1 and day 4, P = 0.0104), while the levels at day 14 decreased significantly compared with those at day 1 (Wilcoxon signed-rank test, P = 0.0499). Aqueous VEGF levels represent the severity of anterior segment ischemia and could be used as an indicator for the extent of ischemia. (C) 1998 Japanese Ophthalmological Society.

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  • Bovine trabecular cells produce TIMP-1 and MMP-2 in response to mechanical stretching 査読

    Y Okada, T Matsuo, H Ohtsuki

    JAPANESE JOURNAL OF OPHTHALMOLOGY   42 ( 2 )   90 - 94   1998年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    Bovine trabecular cells in growth phase were exposed to cyclic mechanical stretching of the bottom of a culture dish at a cycle of 30 seconds for 72 hours, The stretched cells produced significantly larger amounts of metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-1 (TIMP-1) after 72 hours, compared with cells in nonstretched control. In contrast, TIMP-2 and MMP-9 levels were not influenced by mechanical stretching. Trabecular cells would modify extracellular matrix in response to such mechanical stimuli as bending of trabecular meshwork or aqueous flow by the production of TIMP-1 and MMP-2. (C) 1998 Japanese Ophthalmological Society.

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  • Geographic choroiditis and retinal vasculitis in rheumatoid arthritis 査読

    Toshihiko Matsuo, Ikuya Masuda, Nobuhiko Matsuo

    Japanese Journal of Ophthalmology   42 ( 1 )   51 - 55   1998年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A 37-year-old man developed geographic choroiditis and retinal vasculitis in the left eye while taking 3.5 mg/day oral prednisolone for rheumatoid arthritis. The choroidal lesions stopped growing when the dose of prednisolone was increased to 60 mg/day, while its tapering resulted in the recurrence and enlargement of the choroidal lesions to the macula. The patient experienced further recurrence twice in the following year. Indocyanine green angiography demonstrated the obstruction of choroidal arteries in addition to the complete obstruction of the choriocapillaris in a fresh lesion. This case was the first to have geographic choroiditis on the background of a systemic inflammatory disease.

    DOI: 10.1016/S0021-5155(97)00102-0

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  • Metastasis to the iris in squamous cell lung cancer 査読

    Akio Hiraki, Hiroshi Ueoka, Toshihiko Matsuo, Tomio Nakagawa, Tadashi Yoshino, Katsuyuki Kiura, Masahiro Tabata, Katsuyoshi Sakae, Yuji Ohtsuki, Yoshio Hiraki, Mine Harada

    International Journal of Clinical Oncology   3 ( 3 )   186 - 190   1998年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A 72-year-old Japanese woman, suffering from squamous cell lung cancer with brain metastasis, underwent 2 courses of combination chemotherapy, consisting of cisplatin and vindesine. Although both the primary tumor and the brain metastasis regressed markedly, she developed left ocular pain with blurred vision. An abnormal mass was found in the left iris, and cytologic examination of the aqueous aspirate revealed a few malignant cells, which, when examined by electron microscopy, were considered to be derived from squamous cell carcinoma of the lung.

    DOI: 10.1007/BF02489914

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  • Bilateral iridocyclitis with retinal capillaritis in juveniles 査読

    T. Matsuo, N. Matsuo

    Ophthalmology   104 ( 6 )   939 - 944   1997年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier Inc.  

    Purpose: The authors present clinical features of 18 juvenile patients with a new type of uveitis termed bilateral iridocyclitis with retinal capillaritis (BIRC). Methods: The authors reviewed medical records of 18 consecutive patients who showed bilateral iridocyclitis with retinal capillary leakage but no systemic manifestations during an 11-year period from January 1985 to December 1995. Results: Twelve of the 18 patients were female and the age at onset ranged from 9 to 17 years old. All patients had many cells in the anterior chamber and anterior vitreous, together with mutton fat keratic precipitates. Fluorescein angiography showed leakage from the optic disc and retinal capillaries, mainly in the midperiphery, which corresponded to retinal cloudiness. Macular edema was minimal, and all patients maintained good vision. The inflammation responded well to topical, oral, and intravenous administration of corticosteroids, the choice of which was based on the extent of retinal inflammation. Human leukocyte antigen (HLA)-DR6 and HLA-Cw7 were associated significantly with the presence of BIRC (chi square test, P &lt
    0.0001). Conclusions: Bilateral retinal capillaritis affecting capillaries in various areas of the retina and overlying retinal cloudiness with no distinct lesions are unique to these patients. Fluorescein angiography is essential for diagnosis of BIRC.

    DOI: 10.1016/S0161-6420(97)30203-6

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  • ANOMALOUS POSTERIOR INSERTION OF MEDIAL RECTUS MUSCLE SIMULATING CONGENITAL OCULOMOTOR PALSY 査読

    M OKANO, T MATSUO, H KONISHI, S HASEBE, Y TADOKORO, H OHTSUKI

    JAPANESE JOURNAL OF OPHTHALMOLOGY   34 ( 3 )   275 - 279   1990年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN J OPHTHALMOL  

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  • Familial hypo-retinol-binding proteinemia found in a child with keratomalacia 査読

    T. Matsuo, N. Matsuo, F. Shiraga, N. Koide

    Journal of Japanese Ophthalmological Society   92 ( 4 )   694 - 698   1988年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    Retinol-binding protein (RBP) is a plasma protein with a molecular weight of 21,000 synthesized in the hepatocytes, binds with retinol (vitamin A), and transports it to peripheral tissues. Keratomalacia is caused by deficiency of vitamin A itself and/or protein-calorie malnutrition in the latter of which production of RBP is inhibited. We found for the first time familial hypo-retinol-binding proteinemia in a child at an age of 19 months who developed keratomalacia during measles infection in spite of good nourishment. The patient, her sister and mother showed persistent low levels, about half the normal levels of retinol and RBP which were unresponsive to oral vitamin A and protein diet. But they had normal liver function tests, normal levels of the other serum proteins, lipids, and fat-soluble vitamins. This hypo-retinol binding proteinemia was thought to predispose the child to develop keratomalacia during measles. The family members involved would be heterozygous for the normal gene and the defective gene of RBP.

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  • Mild type acute retinal necrosis syndrome involving both eyes at three-year interval 査読

    T. Matsuo, T. Nakayama, T. Koyama, N. Matsuo

    Japanese Journal of Ophthalmology   31 ( 3 )   455 - 460   1987年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A 44-year-old man was seen as having acute retinal necrosis syndrome involving both eyes at an interval of 3 years. The cement-like exudates typical to this disease were observed in the fundus of both eyes
    they were self-limiting, finally resulting in retinochoroidal degeneration without retinal detachment before becoming confluent. The patient showed an elevation of the convalescent antibody titer to varicella-zoster virus in the aqueous humor during the second eye involvement. We suggest that there exists a self-limiting mild type of acute retinal necrosis syndrome of which the present case is an example.

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    加持 達弥, 山崎 修, 森実 真, 松尾 俊彦, 田端 雅弘, 勝井 邦彰, 脇 隆博

    日本皮膚科学会雑誌   129 ( 5 )   1177 - 1177   2019年5月

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    記述言語:日本語   出版者・発行元:(公社)日本皮膚科学会  

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  • Okayama Univ. e-Bulletin OU-MRU 2018.06 Vol.53 Okayama University Research: Successful implantation and testing of retinal prosthesis in monkey eyes with retinal degeneration

    Okayama University Medical Research Updates (OU-MRU) Vol. 53   53   1 - 3   2018年

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  • Novel disposable injector (OUReP Injector) tested in rabbits’ eyes for subretinal implantation of Okayama University-type retinal prosthesis (OUReP). 査読

    Matsuo T, Uchida T, Yamashita K, Matsuo C, Kawakami Y, Hitomi T, Taga K, Sanada T, Yamashita Y, Kuramoto K

    Animal Eye Research   37   1 - 12   2018年

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  • Okayama Univ. e-Bulletin OU-MRU 2018.01 Vol.47 Okayama University Research: Candidate genes for eye misalignment identified

    Okayama University Medical Research Updates (OU-MRU) Vol. 47   47   1 - 3   2018年

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  • 岡山県医用工学研究会25周年記念誌「岡山県ものづくり中小企業と連携して進める岡山大学方式人工網膜(OUReP)」

    松尾俊彦

    岡山県医用工学研究会25周年記念誌   38 - 39   2017年

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  • Nephrotic syndrome during the tapering of oral steroids after pathological diagnosis of Kimura disease from a lacrimal gland mass: case report and review of 10 Japanese patients.

    Toshihiko Matsuo, Takehiro Tanaka, Masaru Kinomura

    Journal of Clinical and Experimental Hematopathology   57 ( 3 )   147 - 152   2017年

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  • Orbital MALT lymphoma after autologous stem cell transplantation for follicular lymphoma as relapse of diffuse large B-cell lymphoma.

    Toshihiko Matsuo, Takehiro Tanaka, Nobuharu Fujii

    Journal of Clinical and Experimental Hematopathology   56 ( 3 )   170 - 175   2017年

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  • 日本医師会ドクタラーゼ大学紹介:岡山大学 Research 「これからの医療を目指して」

    松尾俊彦

    日本医師会発行 ドクタラーゼ 医学生がこれからの医療を考えるための情報誌   20   36 - 36   2017年

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  • 特集「高機能フィルム・シートと製造技術 」ポリエチレンフィルムを利用した人工網膜の実用化に向けて<色素固定薄膜型人工網膜(OURePTM)の実用化に向けた医工連携研究>

    内田哲也, 松尾俊彦

    プラスチックス 2017年3月号   2017年

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  • プラスチックス2017年3月号特集「高機能フィルム・シートと製造技術」「ポリエチレンフィルムを利用した人工網膜の実用化に向けて<色素固定薄膜型人工網膜(OUReP)の実用化に向けた医工連携研究>」

    内田哲也, 松尾俊彦

    プラスチックス2017年3月号   ( 3 )   2017年

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  • Okayama Univ. e-Bulletin OU-MRU 2017.04 Vol.39 Okayama University Research: Successful test of retinal prosthesis implanted in rats

    Okayama University Medical Research Updates (OU-MRU) Vol. 39   39   1 - 3   2017年

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  • 抗PD-1抗体治療後BRAF阻害療法中の進行期メラノーマ患者に生じた原田病 抗PD-1投与前後の免疫応答を含めて

    岩月 啓氏, 山崎 修, 加持 達弥, 濱田 利久, 森実 真, 立川 聖子, 松尾 俊彦, 栄川 伸吾, 鵜殿 平一郎

    西日本皮膚科   78 ( 5 )   554 - 554   2016年10月

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    記述言語:日本語   出版者・発行元:日本皮膚科学会-西部支部  

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  • Apoptosis reduction by a photoelectric dye used for Okayama University-type retinal prosthesis (OUReP (TM))

    Shihui Liu, Toshihiko Matsuo, Osamu Hosoya, Tetsuya Uchida

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   57 ( 12 )   2016年9月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:ASSOC RESEARCH VISION OPHTHALMOLOGY INC  

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  • Tadao Nakago, 1933-2016 IN MEMORIAM

    Toshihiko Matsuo, Chie Nakago-Matsuo

    AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS   149 ( 5 )   771 - 772   2016年5月

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    記述言語:英語   出版者・発行元:MOSBY-ELSEVIER  

    DOI: 10.1016/j.ajodo.2016.03.002

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  • いちょう並木 岡山大学広報誌 2016年6月 No.81 岡山大学が誇る!注目の最先端研究「医工連携で、新方式の人工網膜を開発 光を失った患者に、新たな”光”を届ける」

    松尾俊彦, 内田哲也

    いちょう並木   81   5 - 6   2016年

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  • American Journal of Orthodontics and Dentofacial Orthopedics"In Memorium, Tadao Nakago, 1933-2016"

    Toshihiko Matsuo, Chie Nakago-Matsuo

    American Journal of Orthodontics and Dentofacial Orthopedics   149 ( 5 )   771 - 772   2016年

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  • 岡山医学会雑誌「色素結合薄膜型(岡山大学方式)の人工網膜(OUReP)の医師主導治験」

    松尾俊彦, 内田哲也

    岡山医学会雑誌   127 ( 3 )   223 - 229   2015年

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  • Intraocular relapse with hypopyon and retinal infiltrates after chemotherapy and peripheral blood stem cell transplantation for extranodal NK/T-cell lymphoma.

    Toshihiko Matsuo, Takehiro Tanaka, Kouichi Ichimura, Yusuke Meguri

    Journal of Clinical and Experimental Hematopathology   55 ( 3 )   157 - 161   2015年

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  • 人工臓器「第52回日本人工臓器学会大会 論文賞(広領域)受賞レポート」

    阿拉木斯, 松尾俊彦, 細谷修, 筒井公子, 内田哲也

    人工臓器   44 ( 1 )   16 - 17   2015年

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  • Okayama University Medical Research Updates (OU-MRU) Vol. 7 "Researchers at Okayama demonstrate the promise of a new approach for stimulating neurons in the eyes of patients with dead photoreceptor cells."

    Toshihiko Matsuo, Tetsuya Uchida

    Okayama University Medical Research Updates (OU-MRU) Vol. 7   7   2015年

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  • 両備てい園記念財団「色素結合薄膜型の人工網膜(OUReP)の医師主導治験を目指して」

    松尾俊彦, 内田哲也

    生物学に関する試験論叢   30   117 - 123   2015年

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  • 文部科学省・厚生労働省 革新的医療技術創出拠点プロジェクト平成26年度成果報告会 岡山大学方式の人工網膜の医師主導治験:生物学的安全性評価・製造・品質管理

    松尾俊彦

    臨床評価 別刷   43 ( Suppl XXXV )   144 - 147   2015年

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  • Intraocular lens implantation in unilateral congenital cataract with minimal levels of persistent fetal vasculature in the first 18 months of life

    Toshihiko Matsuo

    SPRINGERPLUS   3   361   2014年7月

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    記述言語:英語   出版者・発行元:SPRINGER INTERNATIONAL PUBLISHING AG  

    Purpose: To describe the incidence of unilateral congenital cataract associated with minimal (ultrasonically undetectable) levels of persistent fetal vasculature in the first 18 months of the life and to report surgical methods for intraocular lens implantation, using 25-gauge vitrectomy system.
    Methods: Retrospective review was made on 16 consecutive patients with bilateral or unilateral congenital cataract in the first 18 months of the life who underwent surgery at Okayama University Hospital after the introduction of the 25-gauge vitrectomy system from October 2005 to March 2013. As the standard of care at this hospital in the study period, intraocular lenses were not implanted in children with bilateral cataract while intraocular lenses were implanted in those with unilateral cataract.
    Results: Ten children with bilateral cataract underwent lensectomy in both eyes with a 25-gauge vitreous cutter under irrigation with a 25-gauge infusion cannula, inserted from two side ports at the corneal limbus. Six children with unilateral cataract underwent intraocular lens implantation and posterior capsulotomy after lens aspiration from limbal side ports. No patient showed vitreous abnormalities on ultrasound examinations before the surgery. At the surgery, all 10 children with bilateral cataract showed no additional abnormalities. In contrast, 3 children with unilateral cataract at the age younger than 12 months showed white fibrous tissue in the anterior vitreous integrated with the posterior lens capsule while the other 3 children with unilateral cataract at the age from 12 to 18 months did not have vitreous abnormalities. The fibrous tissue was cut together in the process of posterior capsulotomy from a 25-gauge trocar inserted at 1.5 mm posterior from the corneal limbus.
    Conclusions: Unilateral congenital cataract in the first 12 months of the life has a high incidence for the association with anterior type of persistent fetal vasculature which could not be detected by preoperative ultrasound examinations. Intraocular lens implantation was technically feasible in unilateral cataract with or without minimal levels of persistent fetal vasculature in the first 18 months of the life.

    添付ファイル: congenital cataract Springerplus.pdf

    DOI: 10.1186/2193-1801-3-361

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  • Glass transition temperature of dried lens tissue pretreated with trehalose, maltose, or cyclic tetrasaccharide

    Tetsuhiro Kawata, Toshihiko Matsuo, Tetsuya Uchida

    SPRINGERPLUS   3   317   2014年6月

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    記述言語:英語   出版者・発行元:SPRINGER INTERNATIONAL PUBLISHING AG  

    Purpose: Glass transition temperature is a main indicator for amorphous polymers and biological macromolecules as materials, and would be a key for understanding the role of trehalose in protecting proteins and cells against desiccation. In this study, we measured the glass transition temperature by differential scanning calorimetry of dried lens tissues as a model of a whole biological tissue to know the effect of pretreatment by trehalose and other sugars.
    Methods: Isolated porcine lenses were incubated with saline, 100 or 1000 mM concentration of trehalose, maltose, or cyclic tetrasaccharide dissolved in saline at room temperature for 150 minutes. The solutions were removed and all samples were dried at room temperature in a desiccator until no weight change. The dried tissues were ground into powder and placed in a measuring pan for differential scanning calorimetry.
    Results: The glass transition temperature of the dried lens tissues, as a mean and standard deviation, was 63.0 +/- 6.4 degrees C (n = 3) with saline pretreatment; 53.0 +/- 0.8 degrees C and 56.3 +/- 2.7 degrees C (n = 3), respectively, with 100 and 1000 mM trehalose pretreatment; 56.0 +/- 1.6 degrees C and 55.8 +/- 1.1 degrees C (n = 3), respectively, with 100 and 1000 mM maltose pretreatment; 60.0 +/- 8.8 degrees C and 59.2 +/- 6.3 degrees C (n = 3), respectively, with 100 and 1000 mM cyclic tetrasaccharide pretreatment. The glass transition temperature appeared lower, although not significantly, with trehalose and maltose pretreatments than with saline and cyclic tetrasaccharide pretreatments (P > 0.05, Kruskal-Wallis test). The glass transition temperature of the dried lens tissues with trehalose pretreatment appeared more noticeable on the thermogram, compared with other pretreatments.
    Conclusions: The glass transition temperature was measured for the first time in the dried lens tissues as an example of a whole biological tissue and might provide a basis for tissue preservation in the dried condition.

    DOI: 10.1186/2193-1801-3-317

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  • Clinicopathological correlation for the role of fluorodeoxyglucose positron emission tomography computed tomography in detection of choroidal malignant melanoma

    Toshihiko Matsuo, Yuka Ogino, Kouichi Ichimura, Takehiro Tanaka, Mitsumasa Kaji

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   19 ( 2 )   230 - 239   2014年4月

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    記述言語:英語   出版者・発行元:SPRINGER JAPAN KK  

    The purpose of this study was to redefine the role of whole-body 2-[F-18]fluoro-2-deoxy-d-glucose (FDG) positron emission tomography fused with computed tomography (PET/CT) in the clinical diagnosis of choroidal malignant melanoma.
    The study design was a retrospective case series involving 7 consecutive patients with choroidal malignant melanoma who underwent enucleation to reach the final pathological diagnosis. FDG-PET/CT was performed together with magnetic resonance imaging and ophthalmological examinations before the surgery. The area, thickness, longest diameter, and circumference of the tumor mass were measured on pathological sections, and were correlated with maximum standardized uptake values (SUVmax) of the tumors on FDG-PET/CT.
    Abnormally high uptake of FDG was noted in the affected eyes of 5 patients, but not in the eyes of 2 patients. The 5 patients with high uptake showed nodular tumors extruding into the vitreous cavity while the 2 patients with absence of uptake showed diffusely infiltrating tumors in the wide area of the choroid with or without a small mushroom-like protrusion. One patient with diffuse infiltration showed concurrent liver metastases with high uptake on PET/CT while another patient with a nodular tumor developed liver metastases a year later. The tumors with higher SUVmax had a tendency to have a wider area and greater thickness on pathological sections (rho = 0.775, P = 0.0557, Spearman rank correlation test).
    FDG-PET/CT showed correlation of the uptake with tumor sizes but was limited in detecting diffusely infiltrating tumors in the choroid without nodular formation.

    DOI: 10.1007/s10147-013-0538-5

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  • 人工臓器「色素結合薄膜型の人工網膜(OUReP)の医師主導治験を目指して」

    松尾俊彦, 内田哲也

    人工臓器   43 ( 3 )   189 - 193   2014年

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  • Mantle cell lymphoma diagnosed by conjunctival salmon-pink lesion biopsy.

    Toshihiko Matsuo, Kouichi Ichimura, Shiro Kubonishi

    Journal of Clinical and Experimental Hematopathology   54 ( 2 )   143 - 147   2014年

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  • Correlation between depth perception by three-rods test and stereoacuity by distance randot stereotest

    Toshihiko Matsuo, Ryo Negayama, Hiroyuki Sakata, Kayoko Hasebe

    Strabismus   22 ( 3 )   133 - 137   2014年

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    記述言語:英語   出版者・発行元:Informa Healthcare  

    Background: The examination of depth perception with three-rods test, in addition to visual acuity testing, is required to obtain motor vehicle license to drive taxies and trucks, according to the Road Traffic Act in Japan. The aim of this study was to examine whether the results of the three-rods test would correlate with the results of static stereopsis tests, used in ophthalmic practice. Methods: This study involved 54 normal subjects, 9 women and 45 men, with ages ranging from 18 to 25 (mean, 20.8) years. All had visual acuity of 0.8 or better with or without glasses or contact lenses correction and had no strabismus at the distant (5m) or near (0.3m) fixation. TNO Stereotest and Titmus Stereotest were examined at 40cm while Distance Randot Stereotest was at 3m. At three-rods test, a central rod was moved at the speed of 50mm/sec forward and backward automatically against two laterally located fixed rods, placed inside the illuminated box. An examinee at the distance of 2.5m observed the rods inside the box from a small viewing window and pushed a button to stop the central rod in alignment with the fixed rods. Erred distance (mm) of the central rod from the fixed rods as a mean of 4 measurements was correlated with stereoacuity in second of arc, measured by three kinds of the stereopsis tests. Results: The erred distance of three-rods test was positively correlated with static stereoacuity at distance measured with Distance Randot Stereotest (ρ=0.418, p=0.0023, Spearman rank correlation test) and also with the other stereopsis tests at near fixation. The stereoacuity at near fixation, measured by TNO Stereotest and Titmus Stereotest, was positively correlated with each other (ρ=0.431, p=0.0017). Conclusion: Three-rods test, examining depth perception, together with the response by eye-hand coordination, gave consistent results with distant static stereoacuity when measured with Distance Randot Stereotest. © 2014 Informa Healthcare USA, Inc.

    DOI: 10.3109/09273972.2014.939766

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  • 眼科「眼付属器リンパ腫に対する治療の現状」

    松尾俊彦

    眼科   56 ( 1 )   33 - 40   2014年

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  • 人工臓器「第51回日本人工臓器学会大会 Tominaga Award 2012受賞レポート」

    阿拉木斯, 松尾俊彦, 細谷修, 筒井公子, 内田哲也

    人工臓器   43 ( 1 )   31 - 32   2014年

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  • 機能材料「色素固定薄膜型人工網膜(岡山大学方式人工網膜)の実用化に向けた医工連携の取り組み」

    内田哲也, 松尾俊彦

    機能材料   34 ( 5 )   41 - 47   2014年

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  • Okayama University e-Bulletin "Intellectual Property and Enterprise" Photoelectric dye-coupled thin film as a novel type of retinal prosthesis.

    Toshihiko Matsuo, Tetsuya Uchida

    Okayama University e-Bulletin Vol. 8, 2014   8   2014年

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  • Behavior tests and immunohistochemical retinal response analyses in RCS rats with subretinal implantation of Okayama-University-type retinal prosthesis

    Alamusi, Toshihiko Matsuo, Osamu Hosoya, Kimiko M. Tsutsui, Tetsuya Uchida

    JOURNAL OF ARTIFICIAL ORGANS   16 ( 3 )   343 - 351   2013年9月

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    記述言語:英語   出版者・発行元:SPRINGER JAPAN KK  

    We have developed a photoelectric dye-coupled polyethylene film as a prototype of retinal prosthesis, which we named Okayama University-type retinal prosthesis. The purposes of this study are to conduct behavior tests to assess vision in Royal College of Surgeons (RCS) rats that underwent subretinal implantation of the dye-coupled film and to reveal retinal response to the dye-coupled film by immunohistochemistry. Polyethylene films were made of polyethylene powder at refined purity, and photoelectric dyes were coupled to the film surface at higher density compared with the prototype. Either dye-coupled film or dye-uncoupled plain film used as a control was implanted subretinally from a scleral incision in both eyes of an RCS rat at 6 weeks of the age. Behavior tests 2, 4, 6, and 8 weeks after implantation were conducted by observing head turning or body turning in the direction consistent with clockwise or counterclockwise rotation of a black-and-white-striped drum around a transparent cage housed with the rat. After the behavior tests at 8 weeks, rats' eyes were enucleated to confirm subretinal implantation of the films and processed for immunohistochemistry. In the behavior tests, the number of head turnings consistent with the direction of the drum rotation was significantly larger in RCS rats with dye-coupled- compared with plain-film implantation [P < 0.05, repeated-measure analysis of variance (ANOVA), n = 7]. The number of apoptotic neurons was significantly smaller in eyes with dye-coupled- compared with plain-film implantation (P < 0.05, Mann-Whitney U test, n = 6). In conclusion, subretinal implantation of photoelectric dye-coupled films restored vision in RCS rats and prevented the remaining retinal neurons from apoptosis.

    DOI: 10.1007/s10047-013-0697-1

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  • Postural stability changes during large vertical diplopia induced by prism wear in normal subjects

    Toshihiko Matsuo, Hanako Yamasaki, Hirotaka Yasuhara, Kayoko Hasebec

    Acta Medica Okayama   67 ( 3 )   177 - 183   2013年

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    記述言語:英語  

    To test the effect of double vision on postural stability, we measured postural stability by electric stabilometry before prism-wearing and immediately, 15, 30, and 60min after continuous prism-wearing with 6 prism diopters in total (a 3-prism-diopter prism placed with the base up in front of one eye and with the base down in front of the other eye) in 20 normal adult individuals with their eyes open or closed. Changes in stabilometric parameters in the time course of 60min were analyzed statistically by repeated-measure analysis of variance. When subjects' eyes were closed, the total linear length (cm) and the unit-time length (cm/sec) of the sway path were significantly shortened during the 60-minute prism-wearing (/0.05). No significant change was noted in any stabilometric parameters obtained with the eyes open during the time course. In conclusion, postural stability did not change with the eyes open in the condition of large vertical diplopia, induced by prism-wearing for 60min, while the stability became better when measured with the eyes closed. A postural control mechanism other than that derived from visual input might be reinforced under abnormal visual input such as non-f usionable diplopia.

    DOI: 10.18926/AMO/50411

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  • 日本臨床 増刊号 ANCA関連血管炎の眼病変 「血管炎 -基礎と臨床のクロストーク-」

    日本臨床 増刊号1   71   341 - 346   2013年

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  • Stereoscopic three-dimensional images of an anatomical dissection of the eyeball and orbit for educational purposes

    Toshihiko Matsuo, Yoshimasa Takeda, Aiji Ohtsuka

    Acta Medica Okayama   67 ( 2 )   87 - 91   2013年

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    記述言語:英語  

    The purpose of this study was to develop a series of stereoscopic anatomical images of the eye and orbit for use in the curricula of medical schools and residency programs in ophthalmology and other specialties. Layer-by-layer dissection of the eyelid, eyeball, and orbit of a cadaver was performed by an ophthalmologist. A stereoscopic camera system was used to capture a series of anatomical views that were scanned in a panoramic three-dimensional manner around the center of the lid fissure. The images could be rotated 360 degrees in the frontal plane and the angle of views could be tilted up to 90 degrees along the anteroposterior axis perpendicular to the frontal plane around the 360 degrees. The skin, orbicularis oculi muscle, and upper and lower tarsus were sequentially observed. The upper and lower eyelids were removed to expose the bulbar conjunctiva and to insert three 25-gauge trocars for vitrectomy at the location of the pars plana. The cornea was cut at the limbus, and the lens with mature cataract was dislocated. The sclera was cut to observe the trocars from inside the eyeball. The sclera was further cut to visualize the superior oblique muscle with the trochlea and the inferior oblique muscle. The eyeball was dissected completely to observe the optic nerve and the ophthalmic artery. The thin bones of the medial and inferior orbital wall were cracked with a forceps to expose the ethmoid and maxillary sinus, respectively. In conclusion, the serial dissection images visualized aspects of the local anatomy specific to various procedures, including the levator muscle and tarsus for blepharoptosis surgery, 25-gauge trocars as viewed from inside the eye globe for vitrectomy, the oblique muscles for strabismus surgery, and the thin medial and inferior orbital bony walls for orbital bone fractures. © 2013 by Okayama University Medical School.

    DOI: 10.18926/AMO/49666

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  • Timing of Prophylactic and Early Vitrectomy for First-Presenting or Recurrent Acute Retinal Necrosis Syndrome

    Toshihiko Matsuo

    ACTA MEDICA OKAYAMA   66 ( 6 )   493 - 497   2012年12月

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    記述言語:英語   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    Acute retinal necrosis syndrome (ARNS) is a herpetic infectious eye disease that presents clinicians with difficult decisions to make about the indication and timing of surgical intervention. Here I report 2 patients who underwent prophylactic and early vitrectomy with good visual outcomes. Case 1, a 72-year-old man, had a second recurrence of ARNS in the left eye in 2011 and underwent early vitrectomy in the acute inflammatory phase to remove previously formed vitreous opacity and vitreoretinal adhesions, in parallel with intravenous acyclovir and oral prednisolone administration. He had experienced ARNS in the right eye in 1983, in the left eye in 1986, and a recurrence in the left eye in 1999. Case 2, a 66-year-old woman, developed ARNS in the right eye. All of the circumferential retinal lesions became degenerative with intravenous acyclovir and prednisolone. She underwent a vitrectomy in the post-inflammatory phase, since epiretinal proliferation was noted through vitreous opacity with complete posterior vitreous detachment. These cases suggest that early vitrectomy in the acute inflammatory phase would be indicated for pre-existing vitreoretinal adhesions, while prophylactic vitrectomy in the post-inflammatory phase would be indicated for epiretinal proliferation.

    DOI: 10.18926/AMO/49046

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  • Conjunctival Lymphoma Can Be Detected by FDG PET

    Toshihiko Matsuo, Kouichi Ichimura, Takehiro Tanaka, Mitsumasa Kaji

    CLINICAL NUCLEAR MEDICINE   37 ( 5 )   516 - 519   2012年5月

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    記述言語:英語   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Four consecutive patients presented with extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in the conjunctiva. After the initial resection, long-term follow-up without additional therapy showed the clinical relapse. Fluorodeoxyglucose positron emission tomography fused with computed tomography (PET/CT) showed abnormal uptake in the conjunctival relapsed lesions, which were, on reresection, again proven as MALT lymphoma. Small and thin lesions of MALT lymphoma in the conjunctiva can be detected by fluorodeoxyglucose PET/CT. The resolution of PET/CT, delineated in this study, could be applied to the other areas of the body to achieve more accurate staging of lymphoma.

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  • Immunocytochemical Diagnosis as Inflammation by Vitrectomy Cell Blocks in Patients with Vitreous Opacity

    Toshihiko Matsuo, Kouichi Ichimura

    OPHTHALMOLOGY   119 ( 4 )   827 - 837   2012年4月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE INC  

    Purpose: To describe the clinical and cytopathologic characteristics in patients with vitreous opacity of unknown cause or preceding inflammation, diagnosed cytopathologically as inflammation.
    Design: Retrospective case series.
    Participants: Forty-three consecutive patients (61 eyes) who underwent vitrectomy for vitreous opacity of unknown cause or preceding inflammation and were diagnosed cytopathologically with inflammation at one institution in 6 years from 2005 to 2010. During the same period, 11 consecutive patients with vitreous opacity of unknown cause were diagnosed cytopathologically with lymphoma (large B-cell lymphoma) and were excluded from the study.
    Methods: Cell blocks were made by centrifugation of vitrectomy fluid and embedded in paraffin for immunocytochemistry.
    Main Outcome Measures: Cytopathologic and immunocytochemical diagnosis using vitrectomy cell blocks.
    Results: Histiocytes (macrophages), small lymphocytes, neutrophils, and eosinophils were predominant cells, with no atypical large cells on hematoxylin-eosin staining. Immunocytochemically, most predominant cells were CD68-positive histiocytes (macrophages), followed by CD3-positive T cells, but CD20- or CD79a-positive B cells were rarely present. Epithelioid cells, positive for CD68, were found in 4 patients with or without an established diagnosis of sarcoidosis, and giant multinucleated cells were found in 2 patients with suspected preceding self-limiting Vogt-Koyanagi-Harada disease, based on the presence of depigmented red fundi. Inflammation was diagnosed in 2 patients with vitreous opacity who had a preceding onset of brain lymphoma or systemic lymphoma.
    Conclusions: The presence of macrophages, combined with small T lymphocytes, was a major sign in intravitreal inflammation, manifesting as vitreous opacity. A simple technique of cytopathology and immunocytochemistry, using vitrectomy cell blocks, can be performed in most pathology laboratories.
    Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. Ophthalmology 2012;119:827-837 (C) 2012 by the American Academy of Ophthalmology.

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  • Phenotype-phenotype and genotype-phenotype correlations in patients with idiopathic superior oblique muscle palsy

    Sayuri Imai Ohkubo, Toshihiko Matsuo, Kayoko Hasebe, Yoshie Hirai Shira, Emi Itoshima, Hiroshi Ohtsuki

    JOURNAL OF HUMAN GENETICS   57 ( 2 )   122 - 129   2012年2月

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    記述言語:英語   出版者・発行元:NATURE PUBLISHING GROUP  

    Idiopathic superior oblique muscle palsy presents, as quantitative phenotypes, vertical deviation and cyclodeviation in eye alignment on clinical testing, and superior oblique muscle hypoplasia on imaging. We determined ARIX and PHOX2B polymorphisms as genotypes, and analyzed phenotype-phenotype and genotype-phenotype correlations in 37 patients with idiopathic superior oblique muscle palsy. Vertical deviations were measured at upright position of the head and head tilt for 30 degrees to either side, and angles of objective excyclodeviations were determined by image analysis on fundus photographs. Cross-sectional areas of the superior oblique muscle near the eye globe-optic nerve junction were measured by image analysis on coronal sections of magnetic resonance imaging to calculate the paretic-side/normal-side ratios. Among the phenotypes, the increase in vertical deviations elicited by head tilt to the paretic side, the decrease in vertical deviations elicited by head tilt to the normal side and the difference of angles of objective excyclodeviations between the paretic side and normal side were significantly correlated inversely with the paretic-side/normal-side ratios of the cross-sectional areas of the muscle (r=-0.43 with P=0.0084, r=-0.34 with P=-0.038, and r=-0.43 with P=0.009, respectively, n=37, Pearson's correlation test). Fifteen patients with ARIX and/or PHOX2B polymorphisms had significantly greater paretic-side/normal-side ratios of the muscle compared with 20 patients without the polymorphisms (P=0.017, n=35, Mann-Whitney U-test). The patients with ARIX and/or PHOX2B polymorphisms had less hypoplastic superior oblique muscles. Journal of Human Genetics (2012) 57, 122-129; doi: 10.1038/jhg. 2011.138; published online 15 December 2011

    DOI: 10.1038/jhg.2011.138

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  • アレルギーの臨床「アトピー性皮膚炎の眼合併症:白内障と網膜剥離」

    松尾俊彦

    アレルギーの臨床   32 ( 6 )   510 - 515   2012年

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  • 血液内科「眼科領域の両側性、再発性、全身多発性悪性リンパ腫の臨床病態と細胞起源」

    血液内科   65 ( 1 )   33 - 43   2012年

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  • Orbital MALT lymphoma, abdominal Hodgkin lymphoma, and systemic diffuse large B-cell lymphoma develop sequentially in one patient.

    Matsuo T, Ichimura K, Shinagawa K

    Journal of Clinical and Experimental Hematopathology   52   41 - 49   2012年

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  • Optical coherence tomographic parameters as objective signs for visual acuity in patients with retinitis pigmentosa, future candidates for retinal prostheses (vol 14, pg 140, 2011)

    Miho Tamaki, Toshihiko Matsuo

    JOURNAL OF ARTIFICIAL ORGANS   14 ( 4 )   385 - 385   2011年12月

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    記述言語:英語   出版者・発行元:SPRINGER TOKYO  

    DOI: 10.1007/s10047-011-0597-1

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  • Long-Term Effect of External Beam Radiotherapy of Optic Disc Hemangioma in a Patient with von Hippel-Lindau Disease

    Toshihiko Matsuo, Kengo Himei, Kouichi Ichimura, Hiroyuki Yanai, Soichiro Nose, Tetsushige Mimura, Yasuyuki Miyoshi, Tomoyasu Tsushima

    ACTA MEDICA OKAYAMA   65 ( 2 )   135 - 141   2011年4月

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    記述言語:英語   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    An 18-year-old woman with a 2-year history of hypertension and headache was diagnosed with noradrenal in-secreting bilateral adrenal pheochromocytomas with paragangliomas in the background of von Hippel-Lindau disease with family histories and a missense mutation, 712C to T (Arg167Trp) in the VHL gene. She had optic disc hemangioma in the left eye which gradually enlarged and caused serous retinal detachment on the macula in one year. Low-dose external beam radiation (20 Gy) was adminisitered to the left eye using a lens-sparing single lateral technique. She underwent craniotomy for cerebellar hemangioblastoma at the age of 22 years and total pancreatectomy for multiple neuroendocrine tumors at the age of 24 years. In the 6-year follow-up period after the radiotherapy, the optic disc hemangioma gradually reduced in size and its activity remained low, allowing good central vision to be maintained. External beam radiation is recommended as a treatment option for the initial therapy for optic disc hemangioma.

    DOI: 10.18926/AMO/45273

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  • Retinal Vasoproliferative Granulomatous Lesion Associated with Hand Pyoderma Caused by Streptococcus pyogenes

    Toshihiko Matsuo, Miho Tamaki, Takashi Oono

    OCULAR IMMUNOLOGY AND INFLAMMATION   19 ( 1 )   58 - 61   2011年2月

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    記述言語:英語   出版者・発行元:TAYLOR & FRANCIS INC  

    Purpose: To report a retinal vasoproliferative granulomatous lesion in association with pyoderma.
    Design: Single case report.
    Methods: A 32-year-old woman had blurred central vision in the right eye, concurrent with pyoderma of the fingers of both hands, 2 days later followed by fever.
    Results: The patient had a granulomatous lesion in the upper retina, which caused leakage, leading to subretinal and intraretinal accumulation of hard exudates in the posterior pole, together with periphlebitis extending over the wider area of the retina. The culture of the pyodermic lesion detected Streptococcus pyogenes. With the 2-month course of amoxicillin-clavulanate, combined with prednisolone tapered from 30 mg daily, the visual acuity (decimal fraction) in the right eye returned from 0.01 (logMAR = 2) to 0.9 (logMAR = 0.1). However, after the discontinuation of the antibiotics and prednisolone, the retinal lesion became more vasoproliferative and caused leakage to reduce the vision again. The leakage was remedied by laser photocoagulation to the retinal lesion.
    Conclusions: The retinal granulomatous lesion was caused by streptococcal infection in pyoderma and later became more vasoproliferative with macroaneurysms and microaneurysms even after the initial subsidence of the lesion with antibiotics treatment.

    DOI: 10.3109/09273948.2010.509531

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  • Denaturation temperature of dried lens tissue rises with trehalose pretreatment

    Jianan Sun, Toshihiko Matsuo, Tetsuya Uchida

    JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY   103 ( 1 )   387 - 391   2011年1月

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    記述言語:英語   出版者・発行元:SPRINGER  

    Trehalose, a non-reducing disaccharide, is known as an exceptional protector against desiccation and heat stress. Differential scanning calorimetry is a simple tool to determine thermodynamic parameters concerning the structural state of proteins. In this study, we measured denaturation temperature (or melting temperature) of dried lenses to know the effect of trehalose pretreatment. Isolated porcine lenses were incubated in wells without any solution or with saline, 100 mM trehalose, or 100 mM cyclic tetrasaccharide in saline at room temperature for 150 min. The solutions were removed, and all lens samples were dried at room temperature and in room humidity until the weight showed no change. The nucleus of each sample was taken out and placed on a measuring platform for differential scanning calorimetry. The denaturation temperature of the dried lenses significantly rose by about 10 degrees C with 100 mM trehalose pretreatment, compared to no pretreatment, pretreatment with saline or 100 mM cyclic tetrasaccharide (P < 0.05, analysis of variance, P < 0.05, Student-Newman-Keuls tests, n = 7). The denaturation temperature showed no difference among the dried lenses with no pretreatment or pretreatment by saline or cyclic tetrasaccharide. In conclusion, pretreatment with trehalose raises denaturation temperature of the dried porcine lens. Trehalose might stabilize the dried tissue structure to get a higher denaturation temperature.

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  • Local recurrence as immunoglobulin G4 (IgG4)-related disease 10 years after radiotherapy to ocular adnexal extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue.

    Toshihiko Matsuo, Kouichi Ichimura, Tadashi Yoshino

    Journal of Clinical and Experimental Hematopathology   51 ( 2 )   125 - 133   2011年

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  • Immunoglobulin G4 (IgG4)-positive or -negative ocular adnexal benign lymphoid lesions in relation to systemic involvement

    Toshihiko Matsuo, Kouichi Ichimura, Yasuharu Sato, Yasushi Tanimoto, Katsuyuki Kiura, Sou Kanazawa, Toshiaki Okada, Tadashi Yoshino

    Journal of Clinical and Experimental Hematopatholgoy   50 ( 2 )   129 - 142   2011年

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  • Bilateral conjunctival lesions in blastic plasmacytoid dendritic cell neoplasm.

    Toshihiko Matsuo, Kouichi Ichimura, Takehiro Tanaka, Shin Morizane, Keiji Iwatsuki, Motoharu Eguchi, Tadashi Yoshino

    Journal of Clinical and Eperimental Hematopathology   51 ( 1 )   49 - 55   2011年

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  • Postural Stability Changes during the Prism Adaptation Test in Patients with Intermittent and Constant Exotropia

    Toshihiko Matsuo, Akiko Yabuki, Kayoko Hasebe, Yoshie Hirai Shira, Sayuri Imai, Hiroshi Ohtsuki

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   51 ( 12 )   6341 - 6347   2010年12月

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    記述言語:英語   出版者・発行元:ASSOC RESEARCH VISION OPHTHALMOLOGY INC  

    PURPOSE. Computerized static stabilometry is a clinical test in neurologic and muscular diseases to assess postural stability or body sway in a quantitative manner. The purpose of this study was to examine whether postural stability would change in the process of the prism adaptation test in patients with intermittent and constant exotropia.
    METHODS. Postural stability was measured before the prism adaptation test and immediately, 15 minutes, and 60 minutes after the prism adaptation test by computerized static stabilometry in 17 consecutive adult patients with exotropia, including 10 patients with intermittent exotropia and seven with constant exotropia. Stabilometric parameters were compared between patients with intermittent and those with constant exotropia for 60 minutes by repeated-measures analysis of variance as statistical analysis.
    RESULTS. The Romberg quotients for the root mean square areas of the sway path (cm(2)), the area in the condition of the patients' eyes open, divided by that in the condition of the patients' eyes closed, increased significantly in the time course of the prism adaptation test and returned to the pretest level in patients with intermittent exotropia and in patients with constant exotropia (P = 0.0173). No significant difference in the Romberg quotients was noted between the patients with intermittent exotropia and those with constant exotropia.
    CONCLUSIONS. Postural instability became more pronounced by the prism adaptation test in the patients with exotropia. Binocular visual and motor perceptional changes induced by the prism adaptation test could lead to postural instability, with adaptation taking place 60 minutes after the start of the test. (Invest Ophthalmol Vis Sci. 2010;51:6341-6347) DOI:10.1167/iovs.105840

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  • Neuroendocrine tumor (carcinoid) metastatic to orbital extraocular muscle: Case report and literature review

    Toshihiko Matsuo, Kouichi Ichimura, Takehiro Tanaka, Tadasu Takenaka, Tadashi Nakayama

    Strabismus   18 ( 4 )   123 - 128   2010年12月

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    記述言語:英語  

    Purpose: To report a patient who showed neuroendocrine tumor (carcinoid) metastasis to the medial rectus muscle and to review patients' characteristics of carcinoid metastases to the extraocular muscles. Case: A 72-year-old woman, who initially presented with spindle-shaped enlargement of the right medial rectus muscle, was followed for 3 years with a diagnosis of orbital myositis. Initial biopsy of the medial rectus muscle showed inflammation only. She showed remission and exacerbation of right proptosis and eyelid swelling, which responded to oral and intravenous steroids. On the occasion of abdominal computed tomography for ischemic colitis, a large retroperitoneal mass was detected and diagnosed as well-differentiated neuroendocrine tumor. The gradual increase of the medial rectus muscle with optic nerve compression, and hence, visual reduction, prompted a second excisional biopsy of the medial rectus mass, which proved to be neuroendocrine tumor metastasis. Whole body 2-[ 18F]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography fused with computed tomography revealed abnormal uptake only in the right orbit (maximum standardized uptake value: SUVmax3.83), and the patient underwent radiation to the right orbit with the subsidence of the residual mass. Results: The literature review found 15 patients, including this patient, with neuroendocrine tumor metastases to the extraocular muscles. Frequent symptoms and signs were diplopia, proptosis, and ocular motility limitation. Conclusions: Neuroendocrine tumor appears to have propensity to extraocular muscle metastases and its slow growth might pose difficulty in differential diagnoses of orbital myositis. © 2010 Informa Healthcare USA, Inc.

    DOI: 10.3109/09273972.2010.525779

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  • Outpatients Flow Management and Ophthalmic Electronic Medical Records System in University Hospital Using Yahgee Document View

    Toshihiko Matsuo, Akira Gochi, Tsuyoshi Hirakawa, Tadashi Ito, Yoshihisa Kohno

    JOURNAL OF MEDICAL SYSTEMS   34 ( 5 )   883 - 889   2010年10月

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    記述言語:英語   出版者・発行元:SPRINGER  

    General electronic medical records systems remain insufficient for ophthalmology outpatient clinics from the viewpoint of dealing with many ophthalmic examinations and images in a large number of patients. Filing systems for documents and images by Yahgee Document View (Yahgee, Inc.) were introduced on the platform of general electronic medical records system (Fujitsu, Inc.). Outpatients flow management system and electronic medical records system for ophthalmology were constructed. All images from ophthalmic appliances were transported to Yahgee Image by the MaxFile gateway system (P4 Medic, Inc.). The flow of outpatients going through examinations such as visual acuity testing were monitored by the list "Ophthalmology Outpatients List" by Yahgee Workflow in addition to the list "Patients Reception List" by Fujitsu. Patients' identification number was scanned with bar code readers attached to ophthalmic appliances. Dual monitors were placed in doctors' rooms to show Fujitsu Medical Records on the left-hand monitor and ophthalmic charts of Yahgee Document on the right-hand monitor. The data of manually-inputted visual acuity, automatically-exported autorefractometry and non-contact tonometry on a new template, MaxFile ED, were again automatically transported to designated boxes on ophthalmic charts of Yahgee Document. Images such as fundus photographs, fluorescein angiograms, optical coherence tomographic and ultrasound scans were viewed by Yahgee Image, and were copy-and-pasted to assigned boxes on the ophthalmic charts. Ordering such as appointments, drug prescription, fees and diagnoses input, central laboratory tests, surgical theater and ward room reservations were placed by functions of the Fujitsu electronic medical records system. The combination of the Fujitsu electronic medical records and Yahgee Document View systems enabled the University Hospital to examine the same number of outpatients as prior to the implementation of the computerized filing system.

    DOI: 10.1007/s10916-009-9303-8

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  • Two cases of corneal perforation after oral administration of nonsteroidal anti-inflammatory drugs: oral NSAID-induced corneal damage

    Ikuya Masuda, Toshihiko Matsuo, Kazuo Okamoto, Kyoko Matsushita, Hiroshi Ohtsuki

    EUROPEAN JOURNAL OF OPHTHALMOLOGY   20 ( 2 )   454 - 456   2010年3月

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    記述言語:英語   出版者・発行元:WICHTIG EDITORE  

    PURPOSE. To report 2 cases of corneal perforation associated with the use of oral nonsteroidal anti-inflammatory drugs (NSAIDs).
    METHODS. In a 62-year-old woman and a 79-year-old woman, corneal perforation occurred after 7 days and 5 months of oral NSAIDs administration, respectively.
    RESULTS. After NSAIDs were discontinued, the cornea epithelialized and the anterior chamber formed within 14 and 10 days, respectively.
    CONCLUSIONS. It is well known that topical NSAIDs cause corneal perforation. Observations in the present cases suggest that the oral administration of NSAIDs may also cause corneal damage, and hence, medical professionals should consider the risk of damage to the cornea when administering these drugs orally. (Eur J Ophthalmol 2010; 20: 454-6)

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  • Paretic Side/Normal Side Ratios of Cross-Sectional Areas of the Superior Oblique Muscle Vary Largely in Idiopathic Superior Oblique Palsy

    Eriko Uchiyama, Toshihiko Matsuo, Sayuri Imai, Emi Itoshima

    AMERICAN JOURNAL OF OPHTHALMOLOGY   149 ( 3 )   508 - 512   2010年3月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE INC  

    PURPOSE: To search for a new definition of muscle hypoplasia in congenital or idiopathic superior oblique muscle palsy.
    DESIGN: Retrospective case-control study.
    METHODS: Cross-sectional areas of the superior oblique and 4 rectus muscles near the eye globe-optic nerve junction were measured by an image analysis software on magnetic resonance images of 50 patients with congenital or idiopathic superior oblique muscle palsy and 45 patients with other disease conditions serving as a control. The paretic side/contralateral normal side ratios of the cross-sectional areas and the left side/right side ratios were calculated for the superior oblique muscle palsy patients and the control patients, respectively.
    RESULTS: The 95% confidence intervals in paretic side/contralateral side ratios of cross-sectional areas of the superior oblique muscle were 0.55 to 0.80 in the right-side superior oblique muscle palsy, and 0.48 to 0.75 in the left-side palsy, while the 95% confidence interval in the left side/right side ratios was 0.99 to 1.00 in the control. The 95% confidence intervals in the left side/right side ratios of the 4 rectus muscles were 1.00, both in the superior oblique muscle palsy and in the control.
    CONCLUSIONS: The muscle hypoplasia could be defined as such when the paretic side/contralateral side ratios of cross-sectional areas of the superior oblique muscle on magnetic resonance images fell outside the 95% confidence interval of the ratios in normal controls. (Am J Ophthalmol 2010;149:508-512. (C) 2010 by Elsevier Inc. All rights reserved.)

    DOI: 10.1016/j.ajo.2009.09.022

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  • Clonal analysis of bilateral, recurrent, or systemically multifocal ocular adnexal lymphoma

    Toshihiko Matsuo, Kouichi Ichimura, Hiroyuki Okada, Katsuji Shinagawa, Kunihiro Fukushima, Mitsuhiro Okano, Masaki Otsuka, Tadashi Yoshino

    Journal of Clinical and Experimental Hematopathology   50 ( 1 )   27 - 38   2010年

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  • Safety, efficacy, and quality control of a photoelectric dye-based retinal prosthesis (Okayama University-type retinal prosthesis) as a medical device

    Toshihiko Matsuo, Tetsuya Uchida, Kenichi Takarabe

    JOURNAL OF ARTIFICIAL ORGANS   12 ( 4 )   213 - 225   2009年12月

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    記述言語:英語   掲載種別:書評論文,書評,文献紹介等   出版者・発行元:SPRINGER TOKYO  

    Patients with retinitis pigmentosa lose photoreceptor cells as a result of genetic abnormalities and hence become blind. Neurons such as bipolar cells and ganglion cells remain alive even in the retina of these patients, and ganglion cells send axons to the brain as the optic nerve. The basic concept of retinal prostheses is to replace dead photoreceptor cells with artificial devices to stimulate the remaining neurons with electric currents or potentials. Photodiode arrays and digital camera-type electrode arrays are the two main approaches for retinal prostheses to stimulate retinal neurons, but these arrays have the problems of poor biocompatibility, low sensitivity, and low output of electric currents, and hence have a requirement for external electric sources (batteries). To overcome these problems, we are developing photoelectric dye-based retinal prostheses that absorb light and convert photon energy to generate electric potentials. The prototype, using a photoelectric dye-coupled polyethylene film, could induce intracellular calcium elevation in photoreceptor-lacking embryonic retinal tissues and cultured retinal neurons. The subretinal implantation of the prototype in the eyes of Royal College of Surgeons (RCS) rats led to vision recovery as proved by a behavior test. The photoelectric dye that was chosen for the prototype did not exhibit any cytotoxicity. The surface potentials of the photoelectric dye-coupled film showed a rapid on-and-off response to illumination with a threshold for light intensity as measured by a Kelvin probe system. Photoelectric dye-based retinal prostheses are thin and soft, and therefore, a sheet of the film of large size, corresponding to a large visual field, could be inserted into the vitreous and then to the subretinal space through a small opening by rolling up the film. Clinical studies of photoelectric dye-based retinal prostheses in patients with retinitis pigmentosa who lose sight will be planned after the manufacturing control and the quality control had been established for the medical device.

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  • Is Refraction with a Hand-Held Autorefractometer Useful in Addition to Visual Acuity Testing and Questionnaires in Preschool Vision Screening at 3.5 Years in Japan?

    Toshihiko Matsuo, Chie Matsuo, Keiko Kio, Naofumi Ichiba, Hiroaki Matsuoka

    ACTA MEDICA OKAYAMA   63 ( 4 )   195 - 202   2009年8月

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    記述言語:英語   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    The vision-screening program for 3.5-year-old children in Japan consists of 3 steps: questionnaires and home visual acuity testing, visual acuity testing by nurses and inspection by medical officers at regional Public Health Centers, and examinations by ophthalmologists. In this study, we tested refraction with a hand-held autorefractometer in addition to visual acuity testing and inspection to reveal whether or not autorefraction leads to better detection of eye problems. Autorefraction was performed in 6 consecutive sessions by a single examiner in 265 children at 3.5 years of age who all visited the same center. The children were sent to the third step of examinations by ophthalmologists based on refractive error criteria: > 3 diopters myopia or > 1 diopter hyperopia, and/or > 2 diopters astigmatism in either eye, in addition to the current criteria: 1) failure in either eye for 0.5 visual acuity at the center, 2) eye-related symptoms revealed by the questionnaires, or 3) eye problems detected by medical officers. Notices to visit ophthalmologists were issued for 64 children (24%), and 37 of those (58%) made the visits, so that documents containing final diagnoses were sent back to the Public Health Office. Of the 64 children, 12 were sent to ophthalmologists based on the current criteria only, 10 based on both the current criteria and the refractive error criteria, and 42 based on the refractive error criteria only. Twelve of the 13 children visiting ophthalmologists by the current criteria had diagnoses such as amblyopia and strabismus. In contrast, 15 of 24 children visiting ophthalmologists by only the refractive error criteria had mainly diagnoses of refractive errors, with no serious problems. In conclusion, autorefraction in addition to visual acuity testing and inspection led to detection of only one additional case of an eye disease at 3.5 years, while tripling the number of children sending to the third-step examination by an ophthalmologist. Thus, from a cost-effectiveness standpoint, autorefraction is not recommended as an additional test when the current system is conducted as designed.

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  • Investigation of parent-of-origin effect in comitant strabismus using MOD score analysis

    Sherin Shaaban, Toshihiko Matsuo, Konstantin Strauch, Hiroshi Ohtsuki

    MOLECULAR VISION   15 ( 141-42 )   1351 - 1358   2009年7月

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    記述言語:英語   出版者・発行元:MOLECULAR VISION  

    Purpose: Comitant strabismus is a common pediatric ophthalmic disorder with both genetic and non-genetic factors contributing to its etiology. The aim of the current study is to investigate the phenomenon of a parent-of-origin effect, genomic imprinting, as a possible mode of inheritance in comitant strabismus.
    Methods: We performed parametric genome-wide MOD score (model-maximizedLOD score) linkage analysis, incorporating imprinting effects, for 382 microsatellite markers in a sample of 258 individuals (117 males and 141 females) from 55 Japanese families with comitant strabismus. We included individuals as affected patients if they presented with comitant esotropia or exotropia based on ophthalmic examination, history taking, or analysis of medical records.
    Results: Significant or suggestive linkage to comitant strabismus with evidence of maternal or paternal imprinting was detected at D4S1575 (4q28.3), D7S486 (7q31.2), D11S1320 (11q24.2), D12S324 (12q24.32), and D19S420 (19q13.11). Using the MOD score approach, we found new evidence of linkage to comitant strabismus at three loci on chromosomes 6q26 (MOD(imp)=MOD(reg)=3.75), 12q24.32 (MOD(imp)=3.36), and 19q13.11 (MOD(imp)=3.79).
    Conclusions: The results suggest that the parent-of-origin effect may play a role in the etiology of comitant strabismus.

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  • Case report and literature review of inferior rectus muscle aplasia in 16 japanese patients

    Toshihiko Matsuo, Tomoko Watanabe, Takashi Furuse, Satoshi Hasebe, Hiroshi Ohtsuki

    Strabismus   17 ( 2 )   66 - 74   2009年6月

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    記述言語:英語  

    Purpose: To describe clinical features of inferior rectus muscle aplasia in Japanese patients and to gain insight into its pathogenesis. Methods: Case presentation and literature review of 16 Japanese patients with inferior rectus muscle aplasia. Results: The age at presentation of 16 patients (9 females, 4 males, and 3 with unknown gender) varied from 7 months to 73 years (mean, 21.8 years). The inferior rectus muscle was absent on the right side in 10 patients, on the left side in 4 patients, and on both sides in 2 patients. Structural anomalies of the eye globe, such as microphthalmos, microcornea, and coloboma of varying degrees, were present on the ipsilateral side of the inferior rectus muscle aplasia in 4 patients and on the contralateral side in 1 patient. As surgical findings, anomalous inferiorly located insertion of the medial rectus muscle was discovered in 5 patients: 1 patient in association with microcornea and iris coloboma. Frequent surgical procedures were recession or tenotomy of the superior rectus muscle, combined with downward transposition of the entire or partial tendons of the medial rectus and lateral rectus muscle to the medial and lateral end, respectively, of the putative inferior rectus muscle insertion. Conclusions: The association of coloboma with inferior rectus muscle aplasia suggests that abnormal optic fissure closure during embryogenesis might underlie the muscle aplasia.

    DOI: 10.1080/09273970802687504

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  • Ophthalmic Artery Embolization as Pretreatment of Orbital Exenteration for Conjunctival Squamous Cell Carcinoma

    Toshihiko Matsuo, Nobuya Ohara, Yuzaburo Namba, Isao Koshima, Kentaro Ida, Susumu Kanazawa

    CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY   32 ( 3 )   554 - 557   2009年5月

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    記述言語:英語   出版者・発行元:SPRINGER  

    The aim of this study is to describe the effect of transarterial embolization from the ophthalmic artery as a pretreatment for orbital exenteration. A 75-year-old Chinese man with a 7-year history of gradual increase of the left eye swelling showed a massive conjunctival tumor growing outwardly from the interpalpebral fissure and had no light perception in the left eye. Magnetic resonance imaging showed orbital invasion of the tumor around the left eyeglobe. The initial surgery for the planned orbital exenteration was discontinued after skin incision around the orbital margin due to massive hemorrhage. The patient underwent transarterial embolization with gelatin sponge (Spongel) of the feeding arteries from the left ophthalmic artery and, the next day, had orbital exenteration with well-controllable bleeding and reconstruction with free vascularized anterolateral thigh cutaneous flap transfer. Pathologically, well-differentiated squamous cell carcinoma proliferated in exophytic, papillary, and nested fashions, arising from the bulbar conjunctiva. Tumor cells were also found in the conjunctival stroma around the vessels. The sclera at the equator had a perforated site with tumor cell invasion, but no intraocular invasion was found. Hematoxylin-positive gelatin sponges were found inside the orbital vessels and large choroidal vessels. In conclusion, transarterial embolization of feeding arteries arising from the ophthalmic artery is a useful pretreatment to control bleeding at orbital exenteration for malignancy.

    DOI: 10.1007/s00270-008-9413-6

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  • Central Retinal and Posterior Ciliary Artery Occlusion After Intralesional Injection of Sclerosant to Glabellar Subcutaneous Hemangioma

    Toshihiko Matsuo, Hiroyasu Fujiwara, Hideo Gobara, Hidefumi Mimura, Susumu Kanazawa

    CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY   32 ( 2 )   341 - 346   2009年3月

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    記述言語:英語   出版者・発行元:SPRINGER  

    The aim of this study is to describe vision loss caused by central retinal artery and posterior ciliary artery occlusion as a consequence of sclerotherapy with a polidocanol injection to a glabellar hemangioma. An 18-year-old man underwent direct injection with a 23-gauge needle of 1 mL of a polidocanol-carbon dioxide emulsion into the glabellar subcutaneous hemangioma under ultrasound visualization of the needle tip by radiologists. He developed lid swelling the next day, and 3 days later at referral, the visual acuity in the left eye was no light perception. Funduscopy revealed central retinal artery occlusion and fluorescein angiography disclosed no perfusion at all in the left fundus, indicating concurrent posterior ciliary artery occlusion. The patient also showed mydriasis, blepharoptosis, and total external ophthalmoplegia on the left side. Magnetic resonance imaging demonstrated the swollen medial rectus muscle. In a month, blepharoptosis and ophthalmoplegia resolved but the visual acuity remained no light perception. Sclerosing therapy for facial hemangioma may develop a severe complication such as permanent visual loss.

    DOI: 10.1007/s00270-008-9382-9

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  • Chromosomes 4q28.3 and 7q31.2 as New Susceptibility Loci for Comitant Strabismus

    Sherin Shaaban, Toshihiko Matsuo, Hirotake Fujiwara, Emi Itoshima, Takashi Furuse, Satoshi Hasebe, Qingrun Zhang, Jurg Ott, Hiroshi Ohtsuki

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   50 ( 2 )   654 - 661   2009年2月

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    記述言語:英語   出版者・発行元:ASSOC RESEARCH VISION OPHTHALMOLOGY INC  

    PURPOSE. This study was designed to localize chromosomal susceptibility loci for comitant strabismus among Japanese families by genome-wide linkage analyses.
    METHODS. Fifty-five Japanese families, with at least two members with comitant strabismus (esotropia and/or exotropia), were subject to full ophthalmic examination, careful ocular history, and review of medical records. DNA was obtained and genotyping was performed with PCR amplification of 400 microsatellite markers. Parametric and nonparametric linkage (NPL) analyses scores were calculated. Linkage analysis was performed for the whole set of families (55 families), and then a second analysis was performed for two subgroups with the phenotypes, esotropia and exotropia.
    RESULTS. A multipoint parametric heterogeneity logarithm of the odds (HLOD) score of 3.62 was obtained at marker D4S1575 under a dominant model, with a NPL score of 2.68 (P = 0.001). Testing under different penetrances and disease allele frequencies revealed two other susceptibility loci at 7q31.2 under a recessive model (HLOD scores = 3.93 and 4.40 at 125.2 cM and 107.28 cM, respectively). Analysis of the subgroups revealed new susceptibility loci for esotropia; one locus at 8q24.21 is worthy of further investigation.
    CONCLUSIONS. This study suggests multiple susceptibility loci for comitant strabismus. The loci at chromosomes 4q28.3 and 7q31.2 show a significant evidence of linkage. (Invest Ophthalmol Vis Sci. 2009;50:654-661) DOI:10.1167/iovs.08-2437

    DOI: 10.1167/iovs.08-2437

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  • Positron emission tomography/computed tomography after immunocytochemical and clonal diagnosis of intraocular lymphoma with vitrectomy cell blocks

    Toshihiko Matsuo, Kouichi Ichimura, Tomotsugu Ichikawa, Yoshihiro Okumura, Mitsumasa Kaji, Tadashi Yoshino

    Journal of Clinical and Experimental Hematopathology   49 ( 2 )   77 - 87   2009年

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  • 大学病院でのヤギー文書・画像による眼科診療管理と専用電子カルテの構築

    松尾俊彦, 合地明, 平川毅, 伊藤忠司, 甲野義久

    臨床眼科   63 ( 4 )   471 - 477   2009年

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  • Orbital exenteration after transarterial embolization in a patient with Wyburn-Mason syndrome: Pathological findings

    Toshihiko Matsuo, Hiroyuki Yanai, Kenji Sugiu, Susumu Tominaga, Yoshihiro Kimata

    JAPANESE JOURNAL OF OPHTHALMOLOGY   52 ( 4 )   308 - 313   2008年7月

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    記述言語:英語   出版者・発行元:SPRINGER TOKYO  

    Background: We present the pathological findings at orbital exenteration in a patient with Wyburn-Mason syndrome who underwent transarterial embolization.
    Case: A 31-year-old man with a 10-year history of gradual exacerbation of left exophthalmos and left cheek swelling was found to have facial and orbital arteriovenous malformations on the left side. There was no vascular malformation in the brain. The feeding arteries derived from the left internal maxillary artery, facial artery, and ophthalmic artery. He underwent several courses of transarterial embolization of the feeding arteries from the left internal maxillary artery and then from the facial artery, resulting in no reduction of the arteriovenous malformation. He finally elected to undergo ophthalmic artery embolization in the expectation of a reduction and with the understanding that he would lose sight in his left eye. Two years later, he requested lid-sparing orbital exenteration and reconstruction with cutaneous flap transfer and prosthesis for cosmetic reasons.
    Observations: Pathologically, orbital vascular channels of varying sizes were filled with embolizing glue and had degenerating vascular wall cells surrounded by inflammatory cell infiltration. The central retinal artery in the optic nerve was also filled with the embolizing glue, and the retina lost the ganglion cell layer and inner nuclear layer but maintained the outer nuclear layer and outer segments.
    Conclusions: Marked anastomoses and hence incomplete embolization among the feeding arteries of facial and orbital vascular malformations in Wyburn-Mason syndrome do not respond well to attempts at feeding vessel embolization, which result in unsuccessful closure of the malformation.

    DOI: 10.1007/s10384-008-0563-5

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  • Short-term biological safety of a photoelectric dye used as a component of retinal prostheses

    Kazuo Okamoto, Toshihiko Matsuo, Takayuki Tamaki, Akihito Uji, Hiroshi Ohtsuki

    JOURNAL OF ARTIFICIAL ORGANS   11 ( 1 )   45 - 51   2008年4月

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    記述言語:英語   出版者・発行元:SPRINGER TOKYO  

    We have designed a new type of retinal prosthesis with a photoelectric dye that transfers photon energy to generate electric potentials. The purpose of this study was to test the safety of a photoelectric dye, 2-[2-[4-(dibutylami no)phenyl]ethenyl]-3-carboxymethylbenzothiazolium bromide (NK-5962), used for retinal prostheses. The retinal cells, derived from chick neurosensory retinas at the 12-day embryonic stage, were a mixed population of retinal neurons and glial cells, and were cultured for 2 days either under protection from light or under continuous light exposure at 230 lux for 9 h daily in the presence of the photoelectric dye at varying concentrations (1.6 x 10(-5), 1.6 x 10(-6), and 1.6 x 10(-7) M) to assess cell viability by staining live cells and dead cells. Dispersed retinal pigment epithelial cells at the same embryonic stage were incubated with the photoelectric dye at varying concentrations (6.6 x 10(-5), 6.6 x 10(-6), and 6.6 x 10(-)7 M) for 4 h under protection from light or under continuous light exposure at 320 lux to assess cytotoxicity by measuring the activity of lactate dehydrogenase leaking from cells. The majority of retinal cells were alive with only a small percentage of dead cells under the dark condition or the light condition in the presence or the absence of the photoelectric dye. The percentage of dead cells was significantly smaller at higher concentrations of the photoelectric dye (P = 0.0183, two-factor analysis of variance), while the percentage of dead cells was not significantly different between the dark condition and the light condition (P = 0.3102). Percent cytotoxicity values were negative, indicating protective effects in all groups of retinal pigment epithelial cells incubated with varying concentrations of the photoelectric dye. The photoelectric dye showed no cytotoxicity to chick retinal cells or retinal pigment epithelial cells on short-term exposure. In addition, this photoelectric dye might have protective effects on both types of cells.

    DOI: 10.1007/s10047-008-0403-x

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  • Lacrimal sac vascular leiomyoma

    Toshihiko Matsuo, Kouichi Ichimura

    JAPANESE JOURNAL OF OPHTHALMOLOGY   52 ( 2 )   130 - 131   2008年4月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)   出版者・発行元:SPRINGER TOKYO  

    DOI: 10.1007/s10384-007-0502-x

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  • Glial reaction to photoelectric dye-based retinal prostheses implanted in the subretinal space of rats

    Takayuki Tamaki, Toshihiko Matsuo, Osamu Hosoya, Kimiko M. Tsutsui, Tetsuya Uchida, Kazuo Okamoto, Akihito Uji, Hiroshi Ohtsuki

    JOURNAL OF ARTIFICIAL ORGANS   11 ( 1 )   38 - 44   2008年4月

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    記述言語:英語   出版者・発行元:SPRINGER TOKYO  

    We have designed a new type of retinal prosthesis using polyethylene films coupled with photoelectric dye molecules that absorb light and convert photon energy to electric potentials. An extruded-blown film of high-density polyethylene was used as the original polyethylene film. Recrystallized film was made by recrystallization from the melting of the original polyethylene film. A photoelectric dye,2-[2-[4-(dibutylamino)phenyl]ethenyl]-3-carboxymethylbenzothiazolium bromide, was coupled to the two types of polyethylene films through amide linkages. Samples of the original dye-coupled film, the dye-coupled recrystallized film, and the dye-uncoupled plain film were implanted in the subretinal space of normal adult rats. Frozen sections were cut from the eyes enucleated at 1 week or 1 month and were either stained with hematoxylin and eosin, stained immunohistochemically for glial fibrillary acidic protein (GFAP), or processed for in situ apoptosis detection. The results revealed that retinal tissue damage was negligible with no inflammatory cells and few apoptotic cells. GFAP was significantly up-regulated in retinal sites with the implantation of all types of polyethylene films at 1 week, compared with the adjacent retinal sites (P < 0.005, analysis of variance). The GFAP up-regulation was also present at 1 month for the plain film and dye-coupled recrystallized film (P < 0.05). Glial cell encirclement around the films increased significantly between 1 week and 1 month (P = 0.023, two-factor analysis of variance) but was not significantly different among the three types of polyethylene films (P = 0.4531). These results showed evidence of glial reactions to the photoelectric dye-coupled polyethylene films implanted into the subretinal space of rat eyes and also proved their basic biological safety.

    DOI: 10.1007/s10047-007-0398-8

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  • Clinical features, ARIX and PHOX2B nucleotide changes in three families with congenital superior oblique muscle palsy

    Sayuri Imai, Toshihiko Matsuo, Emi Itoshima, Hiroshi Ohtsuki

    ACTA MEDICA OKAYAMA   62 ( 1 )   45 - 53   2008年2月

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    記述言語:英語   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    We analyzed nucleotide changes in 3 genes, ARIX, PHOX2B, and KIF21A, in 6 patients of 3 families with congenital superior oblique muscle palsy. Three exons of ARIX, 3 exons of PHOX2B, and exons 8, 20, and 21 of KIF21A were amplified by polymerase chain reaction from genomic DNA isolated from the peripheral blood. The DNA fragments were directly sequenced in both directions. In 2 different families, a heterozygous nucleotide change, ARIX 153G > A, in the 5'-untranslated region was found in common between a father and daughter with muscle palsy and between a mother and daughter with muscle palsy (Family No. I and No. 3). In the other family (Family No. 2), a heterozygous 15-nucleotide deletion, PHOX2B 1124del15, resulting in loss of 5 alanine residues in the alanine repeat of the protein, was found in the daughter with muscle palsy and her father with normal traits, but was not found in the mother with muscle palsy. No KIF21A nucleotide change was found in any patients. The ARIX 153G > A polymorphism might be a genetic risk factor for the development of congenital superior oblique muscle palsy.

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  • 眼科「Schwartz症候群」

    松尾俊彦

    眼科   50   1428 - 1429   2008年

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  • 下直筋欠損の1例

    渡辺智子, 松尾俊彦, 古瀬尚, 長谷部聡, 柳川俊博, 清水敏成, 大月洋

    臨床眼科   62   1309 - 1314   2008年

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  • 斜視患者のプリズム矯正前後の重心動揺と重心位置(予報)

    矢吹明子, 長谷部佳世子, 平井美恵, 松尾俊彦, 大月 洋

    眼科臨床紀要   1   144 - 147   2008年

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  • Different histopathological types of orbital lymphoma 16 years after systematic follicular lymphoma: Immunohistochemical and immunogenetic analysis of two cases.

    Matsuo T, Ichimura K, Shinagawa K, Yoshino T

    J Clin Exp Hematopathol   48   17 - 24   2008年

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  • Schwartz症候群

    松尾俊彦

    眼科   50   1428 - 1429   2008年

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  • Comparison of prevalence rates of strabismus and amblyopia in Japanese elementary school children between the years 2003 and 2005

    Toshihiko Matsuo, Chie Matsuo

    ACTA MEDICA OKAYAMA   61 ( 6 )   329 - 334   2007年12月

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    記述言語:英語   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    We previously revealed the prevalence of strabismus and amblyopia in elementary school children between 6 and 12 years of age in Japan in the year 2003. Questionnaires asking the number of children with different types of strabismus and amblyopia were sent to all elementary schools in Okayama Prefecture in the year 2005, and the results in the year 2005 were compared with those obtained in the year 2003. The number of children covered by the return of questionnaires was 84,619 (74%) of 113,763 total pupils, including grades I to 6, in Okayama Prefecture in the year 2005. The total numbers of children with strabismus and amblyopia, including grades I to 6, were 844 (0.99%, 95% confidence interval: 0.94-1.06%) and 173 (0.20%, 95% confidence interval: 0.17-0.23%), respectively. The numbers of children with any type of exotropia and any type of esotropia were 524 (0.62%) and 187 (0.22%), respectively. In the previous survey conducted in 2003, the number of children covered by the return of questionnaires was 86,531 (76%) of 113,254 total pupils. The total numbers of children with strabismus and amblyopia, were 1,112 (1.28%, 95% confidence interval: 1.24-1.36%) and 125 (0.14%, 95% confidence interval: 0.12-0.17%), respectively. The numbers of children with any types of exotropia and esotropia were 602 (0.69%) and 245 (0.28%), respectively. The prevalence of strabismus in this large population of Japanese elementary school children was significantly different between the years 2003 and 2005, while the prevalence of amblyopia was similar between the years.

    DOI: 10.18926/AMO/32877

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  • Vogt-koyanagi-harada syndrome in two patients with immunoglobulin a nephropathy

    Toshihiko Matsuo, Ikuya Masuda, Kosuke Ota, Ichiro Yamadori, Reiko Sunami, Soichiro Nose

    ACTA MEDICA OKAYAMA   61 ( 5 )   305 - 309   2007年10月

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    記述言語:英語   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    We describe herein 2 patients who developed Vogt-Koyanagi-Harada syndrome in the course of renal biopsy-proven immunoglobulin A (IgA) nephropathy. A 61-year-old man with an 11-year history of IgA nephropathy and a 16-year history of thyroiditis, and a 56-year-old man with a 5-year history of IgA nephropathy developed Vogt-Koyanagi-Harada syndrome. At the time of the eye disease presentation, IgA nephropathy was stable without corticosteroids in both patients. Vogt-Koyanagi-Harada syndrome was successfully treated with intravenous administration of prednisolone tapered from 200 mg daily. Vogt-Koyanagi-Harada syndrome is associated with IgA nephropathy, suggesting a similar autoimmune mechanism for both diseases.

    DOI: 10.18926/AMO/32898

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  • Visual acuity and perimacular retinal layers detected by optical coherence tomography in patients with retinitis pigmentosa

    Toshihiko Matsuo, Noriko Morimoto

    BRITISH JOURNAL OF OPHTHALMOLOGY   91 ( 7 )   888 - 890   2007年7月

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    記述言語:英語   出版者・発行元:B M J PUBLISHING GROUP  

    Background: The remaining retinal neurones or layered structure in the degenerating retina have been the prerequisite for epiretinal or subretinal retinal prostheses.
    Aim: To detect the layered structure in the eyes of patients with retinitis pigmentosa by optical coherence tomography.
    Methods: In a prospective non- comparative study, 115 eyes of 58 consecutive patients with retinitis pigmentosa underwent optical coherence tomography to obtain horizontal and vertical retinal cross- section images at the centre of the macula. The number of high- reflectance retinal layers, one, two or three layers, was tested to determine whether it correlates with best-corrected visual acuity.
    Results: The best- corrected visual acuity was significantly better in the eyes in which more retinal layers were detected ( p < 0.001, Kruskal - Wallis test, p < 0.05, Tukey - Kramer test). The best- corrected visual acuity in the right eye and in the left eye was correlated with each other ( p < 0.001, Spearman rank correlation test) and decreased with age.
    Conclusions: Optical coherence tomography can be used to obtain information regarding the retinal layer structure in patients with retinitis pigmentosa, and may be used as a clinical test to assess the feasibility of retinal prostheses in future.

    DOI: 10.1136/bjo.2007.114538

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  • Eye manifestations in patients with perinuclear antineutrophil cytoplasmic antibody-associated vasculitis: Case series and literature review

    Toshihiko Matsuo

    JAPANESE JOURNAL OF OPHTHALMOLOGY   51 ( 2 )   131 - 138   2007年3月

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    記述言語:英語   出版者・発行元:SPRINGER TOKYO  

    Purpose: To report and summarize eye manifestations of patients with perinuclear pattern antineutrophil cytoplasmic antibody [pANCA, myeloperoxidase (MPO)-ANCA]-associated vasculitis.
    Methods: The medical records of four consecutive patients with pANCA (MPO-ANCA) vasculitis who showed eye manifestations were retrospectively reviewed. In addition, the medical literature databases, PubMed and Japana Centra Revuo Medicina for Japanese literature, were searched for pANCA vasculitis patients with eye manifestations.
    Results: Three of the four patients treated at the Okayama University Hospital showed unilateral or bilateral scleritis. In the literature review, eight of the 27 patients showed ocular surface manifestations such as scleritis and peripheral keratitis. Other frequent eye presentations were posterior segment manifestations such as central or branch retinal vein occlusion, optic neuropathy, and acute posterior multifocal placoid pigment epitheliopathy (APMPPE). Systemically, the most frequent manifestations were glomerulonephritis in the present patients as well as in the patients reported in the past studies.
    Conclusoins: Ocular surface manifestations and posterior segment manifestations were major eye presentations in patients with pANCA-associated vasculitis. ANCA testing including both pANCA and cytoplasmic pattern antineutrophil cytoplasmic antibody would help establish a systemic diagnosis in patients with eye manifestations such as scleritis, retinal vein occlusion, optic neuropathy, or APMPPE.

    DOI: 10.1007/s10384-006-0408-z

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  • Detection of strabismus and amblyopia in 1.5-and 3-year-old children by a preschool vision-screening program in Japan

    Toshihiko Matsuo, Chie Matsuo, Hiroaki Matsuoka, Keiko Kio

    ACTA MEDICA OKAYAMA   61 ( 1 )   9 - 16   2007年2月

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    記述言語:英語   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    All children at the age of 1.5 and 3 years in Japan undergo physical, mental, and developmental checkups including dental, eye, and hearing examinations. The vision-screening program consists of 3 steps: questionnaires and home visual acuity testing as the first step (only for 3-year-old children), visual acuity testing by nurses and inspection by medical officers at regional Health Centers as the second step, and detailed examinations by ophthalmologists as the third step. This study aims to reveal the prevalence of strabismus and amblyopia as obtained from data in the vision-screening program. The final diagnoses made by ophthalmologists and sent back to the Health Centers in Okayama City were reviewed to elucidate the prevalence of strabismus, amblyopia, refractive errors, and other diseases in 1.5- and 3-year-old children in Okayama City in 5 years from 2000 to 2004. Of approximately 6,500-6,900 total children, 83.7-86.8% at 1.5 years old and 77.8-81.9% at 3 years old were brought to the Health Centers. The rates of strabismus were 0.01-0.12% at 1.5 years old and 0.20-0.34% at 3 years old, while the rates of amblyopia were 0% at 1.5 years old and 0.13-0.18 % at 3 years old. The higher rates of strabismus at 3 years old were attributed mainly to the increase of exotropia and intermittent exotropia. In conclusions, the prevalence of strabismus was different between 1.5- and 3-year-old children. The vision-screening program in Japan functions to detect strabismus and amblyopia.

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  • 岡山県医師会報「角膜移植へのご理解を! 善意とボランティアの輪で成り立つ臓器移植」

    松尾俊彦

    岡山県医師会報   ( 1218 )   421 - 422   2007年

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  • 非ステロイド性抗炎症薬内服中の結合組織病患者2例に発生した角膜融解穿孔

    増田郁也, 松尾俊彦, 松下恭子, 岡本和夫, 大月 洋

    臨床眼科   61   1861 - 1866   2007年

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  • 網膜色素変性の白内障手術結果と患者の満足度 ―ロービジョンケアの立場からの考察―

    守本典子, 松尾俊彦, 大月 洋

    日本眼科紀要   58   153 - 157   2007年

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  • Spontaneous regression of bilateral conjunctival extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue.

    Matsuo T, Ichimura K, Yoshino T

    J Clin Exp Hematopathol   47   79 - 81   2007年

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  • 臨床眼科「眼科専門医に必要な「全身疾患と眼」のすべて 8.血液・造血器疾患および悪性腫瘍 白血病、悪性リンパ腫」

    松尾俊彦

    臨床眼科   61 増刊号   146 - 156   2007年

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  • BRAIN and NERVE 特集 最近注目される脳神経疾患治療の研究 視機能再生工学 ―光電変換色素をポリエチレン・フィルムに固定した人工網膜(岡山大学方式人工網膜)の開発―

    松尾俊彦

    BRAIN and NERVE   59   331 - 338   2007年

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  • 岡山県眼科医会会報「学校眼科検診と学校眼科医」

    松尾俊彦

    岡山県眼科医会会報   145   27 - 31   2007年

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  • Intracellular calcium response and adhesiveness of chick embryonic retinal neurons to photoelectric dye-coupled polyethylene films as prototypes of retinal prostheses

    Akihito Uji, Toshihiko Matsuo, Tetsuya Uchida, Kaoru Shimamura, Hiroshi Ohtsuki

    ARTIFICIAL ORGANS   30 ( 9 )   695 - 703   2006年9月

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    記述言語:英語   出版者・発行元:BLACKWELL PUBLISHING  

    Photoelectric dyes, which absorb light and convert photon energy to electric potentials, were shown to stimulate retinal neurons in culture. One of these dyes coupled with polyethylene film surface, as a prototype of retinal prostheses, could induce intracellular calcium elevation in chick embryonic retinal tissues. In this study, we used retinal cells from chick embryos in which no photoreceptor outer segments yet developed, and assessed cell adhesiveness and response to the original and modified types of our retinal prostheses. Extruded-blown film of high density polyethylene was used as the original polyethylene film. Polyethylene film surface was modified either by coupling with type 1 collagen or by crystallization from the melt of the original polyethylene film. A photoelectric dye, 2-[2-[4-(dibutylamino)phenyl]ethenyl]-3-carboxymethylbenzothiazolium bromide, was coupled to these different types of polyethylene films through amide linkage. Retinal cells from chick embryos at the 12-day embryonic stage were cultured on the surface of dye-coupled films. The response of retinal cells to the dye-coupled films was observed by calcium imaging. Cell types, either neurons or glial cells, were detected by immunocytochemical staining and also observed by scanning electron microscopy (SEM). Intracellular calcium elevation was observed in cells, including both neurons and glial cells, on the surface of the original dye-coupled film, collagen-coated dye-coupled film, and dye-coupled recrystallized film, in contrast with no response of cells cultured on the dye-uncoupled plain film. Retinal neurons grew upon colonies of glial cells settling on the surface of all different types of the films. The number of retinal neurons on the collagen-coated dye-coupled film and dye-coupled recrystallized film was significantly larger than the number of neurons on the dye-uncoupled plain film (P = 0.0004, analysis of variance; P < 0.05, Tukey-Kramer test). With SEM, Muller cell-like large cells covered the original dye-coupled film and collagen-coated dye-coupled film, while neuron-like small cells settled directly on the dye-coupled recrystallized film and also formed large colonies on Muller-like cells. Retinal neurons and glial cells were cultured directly on the different types of dye-coupled polyethylene films. Photoelectric dye-coupled polyethylene films could be used as prototypes of retinal prostheses.

    DOI: 10.1111/j.1525-1594.2006.00286.x

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  • Disappearance of diabetic macular hard exudates after hemodialysis introduction

    Toshihiko Matsuo

    ACTA MEDICA OKAYAMA   60 ( 3 )   201 - 205   2006年6月

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    記述言語:英語   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    We report herein the disappearance of macular hard exudates after the introduction of hemodialysis in diabetic patients. A 62-year-old woman and a 52-year-old man with diabetes mellitus showed hard exudates in the macula of the left eyes. Both patients had previously undergone panretinal photocoagulation in both eyes. During the follow-up, hemodialysis was introduced for deteriorating chronic renal failure caused by diabetic nephropathy. Half a year later, macular hard exudates in the left eyes disappeared dramatically in both patients, but the visual acuity remained the same. No additional laser treatment was done during the observation period. Hemodialysis is considered to have accelerated the resolution of macular hard exudates in both patients. The deposition of macular hard exudates in diabetic patients is due in part to concurrent poor renal function.

    DOI: 10.18926/AMO/30746

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  • Body sway increases immediately after Strabismus surgery

    T Matsuo, A Narita, M Senda, S Hasebe, H Ohtsuki

    ACTA MEDICA OKAYAMA   60 ( 1 )   13 - 24   2006年2月

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    記述言語:英語   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    The purposes of this study were to examine whether body sway is altered immediately after strabismus surgery in children and to find preoperative clinical factors associated with body sway. In a prospective study, body sway was measured on 1-3 days before surgery and on the third day after surgery; for the measurements, computerized static stabilometry was carried out on 28 consecutive patients with strabismus (age range: 3 to 12 years old; mean: 7.4) who underwent strabismus surgery under general anesthesia. The linear length of the sway path (cm), the linear length of the sway path in a particular unit of time (cm/second), and the area of the sway path (cm(2)), indicative of the extent of body sway, all increased significantly among a total of 28 patients in both conditions of the patient's eyes open and closed, as well as among those in a subgroup of 16 patients with exotropia, after they had undergone strabismus surgery (p < 0.05, Wilcoxon signed ranks test). The center of pressure along the Y axis of orientation from the toe to the heel was found to deviate significantly toward the heel postoperatively, as compared with the preoperative center in the subgroup of 16 patients with exotropia (p < 0.05). Before surgery, 15 patients with no stereoacuity exhibited a greater amount of body sway when their eyes were open than did 13 patients with measurable stereoacuity (p < 0.05, Mann-Whitney U-test). In the subgroup of 16 patients with exotropia when their eyes open, 3 patients with abnormal head posture exhibited more extensive body sway than did 13 patients without abnormal head posture (p < 0.05). Body sway was found to significantly increase immediately after strabismus surgery in children with strabismus. Stereoacuity and abnormal head posture are 2 clinical factors associated with preoperative postural instability.

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  • Bartonella henselae bacilli detected in vitrectomy aspirates in a patient with massive vitreous opacity with total retinal detachment

    T Matsuo, K Notohara

    OCULAR IMMUNOLOGY AND INFLAMMATION   14 ( 1 )   47 - 49   2006年2月

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    記述言語:英語   出版者・発行元:TAYLOR & FRANCIS INC  

    Purpose: To present endophthalmitis-like massive vitreous opacity as a manifestation of cat-scratch disease. Methods: Report of a case. Results: A 47-year-old man developed massive vitreous opacity and total retinal detachment in his right eye after a four-month period of uveitis, which was controlled with oral prednisolone. During the diagnostic vitrectomy, a massive fluffy white opacity adhering to the detached retina was shaved using a vitreous cutter. Further surgical procedures to reattach the retina were not pursued because of the poor state of the infected retina. Pathological examination of the vitreous aspirates revealed pleomorphic bacilli. The serological testing done at referral revealed an IgG titer positive for Bartonella henselae and culture of the vitreous proved the infection a month later. With a mixture of oral sulfamethoxazole (1600 mg daily) and trimethoprim (320 mg daily), the intraocular inflammation subsided. Conclusion: Rapid progression of massive vitreous opacity with total retinal detachment, mimicking endophthalmitis, can occur in cat-scratch disease.

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  • アイバンクだより 岡山県アイバンク「アイバンクあれこれ」

    松尾俊彦

    アイバンクだより 岡山県アイバンク   第13号 2-3   2006年

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  • Atomic force microscopic observation of trehalose-treated and dried corneal epithelial surface

    Yuko Izawa, Toshihiko Matsuo, Tetsuya Uchida, Kaoru Shimamura, Hiroshi Ohtsuki

    Cell Preservation Technology   4 ( 2 )   117 - 122   2006年

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    記述言語:英語  

    To search for the mechanism of the effect of trehalose on the ocular surface applied as eye drops, we observed trehalose-treated and dried corneal epithelial surfaces of porcine eyes with atomic force microscopy. Full-thickness corneal pieces, 5 × 5 mm in size, were cut out from enucleated porcine eyes. Three kinds of disaccharides, trehalose, maltose, and sucrose, dissolved in saline at 100 mM concentration, and saline as a control, were applied to the epithelial surface of the full-thickness corneal pieces for 1 min. Excess fluid was then absorbed by cotton tips at the epithelial edge of the pieces, and the corneal pieces were dried naturally at room temperature and in room humidity for 72 h. The dried corneal epithelial surfaces were observed first with a dissecting microscope and then fixed on the observation platform for atomic force microscopy. With dissecting microscopy, trehalose-treated corneal epithelial surfaces appeared smoother than saline-, maltose-, or sucrose-treated surfaces. With atomic force microscopy in a tapping mode, saline-, maltose-, and sucrose-treated corneal epithelial surfaces had a larger number of pits in greater sizes than trehalose-treated surfaces. The number of pits measuring 0.14 μm or larger was significantly less in trehalose-treated corneal epithelial surfaces than in saline-treated surfaces (p = 0.0326, analysis of variance [ANOVA], p &lt
    0.05, Tukey-Kramer test). No significant difference was found in the number of pits between maltose- or sucrose-treated surfaces and saline-treated surfaces. Mean roughness, an indicator for surface roughness, was significantly lower in trehalose-treated surfaces than in sucrose-treated surfaces (p = 0.0181, ANOVA, p &lt
    0.05, Tukey-Kramer test). Trehalose-treated corneal epithelial surfaces are smoother than saline-, maltose-, or sucrose-treated surfaces. One effect of trehalose on the ocular surface is to keep the corneal epithelial surface smooth in drying condition. © Mary Ann Liebert, Inc.

    DOI: 10.1089/cpt.2006.4.117

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  • 岡山医学会雑誌「眼科領域のアレルギー性疾患とアトピー性皮膚炎の眼合併症」

    松尾俊彦

    岡山医学会雑誌   118,131-137   2006年

  • 学校保健おかやま「岡山県内の小学校児童における斜視および弱視の頻度の再調査」

    松尾俊彦

    学校保健おかやま   37,1-4?   2006年

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  • 画像ラボ「岡山大学方式の人工網膜の試作品 光電変換色素をポリエチレン・フィルムに固定した人工網膜の開発」

    松尾俊彦

    画像ラボ   17,36-34   2006年

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  • Aspergillosis causing bilateral optic neuritis and later orbital apex syndrome

    T Matsuo, K Notohara, Yamadori, I

    JAPANESE JOURNAL OF OPHTHALMOLOGY   49 ( 5 )   430 - 431   2005年9月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

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  • Predictive factors for long-term outcome of stereoacuity in Japanese patients with pure accommodative esotropia

    Toshihiko Matsuo, Takashi Yamane, Hirotake Fujiwara, Hiroshi Ohtsuki, Yoshimasa Watanabe

    Strabismus   13 ( 2 )   79 - 84   2005年6月

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    記述言語:英語   掲載種別:書評論文,書評,文献紹介等  

    Purpose: To find clinical factors related to the long-term outcome of stereoacuity in Japanese patients with pure accommodative esotropia, including both the refractive type and the nonrefractive type. Methods: The medical charts of 19 Japanese patients (8 boys and 11 girls) with pure accommodative esotropia who were followed for 10 years or more at Okayama University Hospital were reviewed retrospectively. Refractive accommodative esotropia was diagnosed in 8 patients while nonrefractive accommodative esotropia was diagnosed in 11 patients. The patients were divided into two groups, based on a stereoacuity of 120 seconds of arc or better versus 240 seconds of arc or worse as measured by the TNO test at the final visit, and the clinical factors were compared between the two groups. Results: Clinical factors related to a stereoacuity of 240 seconds of arc or worse at the final visit were higher accommodative convergence to accommodation (AC/A) ratios at 6 years of age (p = 0.05), larger residual esodeviations at distance under full correction with glasses at 8 years of age (p = 0.03), and larger residual esodeviations at near at 6 years of age (p = 0.01, Mann-Whitney U-test). Overall, patients with nonrefractive accommodative esotropia tended to show poor levels of stereoacuity at the final visit compared to those with refractive accommodative esotropia (p = 0.059, Fisher exact probability test). Conclusion: This is the first study of the long-term visual outcome in Japanese patients with pure accommodative esotropia including both refractive and nonrefractive types. To obtain better levels of stereoacuity, the residual esodeviations at near and at distance should be kept as small as possible under full correction with glasses, including bifocals, especially at the ages of 6 and 8 years. Copyright © 2005 Taylor &amp
    Francis Inc.

    DOI: 10.1080/09273970590935084

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  • ARIX and PHOX2B polymorphisms in patients with congenital superior oblique muscle palsy

    Y Jiang, T Matsuo, H Fujiwara, S Hasebe, H Ohtsuki, T Yasuda

    ACTA MEDICA OKAYAMA   59 ( 2 )   55 - 62   2005年4月

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    記述言語:英語   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    To identify ARIX gene and PHOX2B gene polymorphisms in patients with congenital superior oblique muscle palsy, 3 exons of the ARIX gene and PHOX2B gene were sequenced by genomic DNA amplification with polymerase chain reaction (PCR) and direct sequencing in 31 patients with congenital superior oblique muscle palsy and in 54 normal individuals. A family with a father and one daughter each having congenital superior oblique muscle palsy was also included in this study. Eleven patients with congenital superior oblique muscle palsy had heterozygous nucleotide changes in the ARIX gene, including 4 patients reported on previously. One patient with atrophy of the superior oblique muscle had a new change of T-4G in the promoter region of the ARIX gene. The other 6 patients had a heterozygous nucleotide change of G153A in the 5'-untranslated region (UTR) of the exon 1 of the ARIX gene. These nucleotide changes of the ARIX gene, taken together, had a significant association with congenital superior oblique muscle palsy (P = 0.0022). One patient and 5 patients had heterozygous nucleotide changes of A1106 C and A1121 C in exon 3 of the PHOX2B gene, respectively, while these changes were absent in the normal individuals,. Two patients had both the G153A change in the 5'-UTR of exon 1 of the ARIX gene and the A1121 C change in exon 3 of the PHOX2B gene. In conclusion, the polymorphisms of the ARIX gene and PHOX2B gene may be genetic risk factors for the development of congenital superior oblique muscle palsy.

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  • First presenting signs or symptoms of sarcoidosis in a Japanese population

    T Matsuo, N Fujiwara, Y Nakata

    JAPANESE JOURNAL OF OPHTHALMOLOGY   49 ( 2 )   149 - 152   2005年3月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE INC  

    Purpose: To determine the first presenting signs or symptoms or other reasons leading to the diagnosis of sarcoidosis.
    Methods: A retrospective review was made of the records of 123 consecutive Japanese patients with histopathological diagnosis of sarcoidosis seen at a referral-based university hospital.
    Results: At the first presentation. eye symptoms in 32 patients. abnormal chest X-ray findings in 52 patients. common cold-like symptoms in 12 patients, lymphadenopathy in 6 patients, skin lesions in 14 patients. and examinations for other diseases in 4 patients led to the final diagnosis. Overall. uveitis was detected in 60 patients (50%) during the follow-up.
    Conclusions: Mass screening programs of chest X-rays are the major way sarcoidosis is detected in Japan. Uveitis is seen in about half the patients during the course of sarcoidosis, and eye symptoms are frequent first presentations of sarcoidosis. These facts emphasize the role of ophthalmologists in the diagnosis and management of sarcoidosis.

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  • Recurrent versus non-recurrent or no eye involvement in Behcet's disease

    T Matsuo, M Itami

    OCULAR IMMUNOLOGY AND INFLAMMATION   13 ( 1 )   73 - 77   2005年2月

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    記述言語:英語   出版者・発行元:TAYLOR & FRANCIS INC  

    Purpose: The aim of this study was to note the clinical features of patients with Behcet's disease who did not show recurrent episodes of eye involvement during long-term follow-up. Methods: A retrospective review was made of 70 Japanese patients with Behcet's disease who were seen during a 23-year period from 1974 to 1996 and followed for five or more years at Okayama University Hospital. The 70 patients were divided into three groups: 36 patients with recurrent episodes of eye involvement; 13 patients with non-recurrent one-time only eye involvement; and 21 patients with no eye involvement at all during a follow-up period of five or more years. Clinical features were compared between these three groups. Results: Female sex (p = 0.0263, chi-square test), young age at the onset (p = 0.0322, Kruskal-Wallis test), and genital ulceration (p = 0.0003, chi-square test) were significantly associated with the non-recurrent or no eye involvement patients. Conclusions: Female patients with onset at a young age and who show the three signs of skin lesions and oral and genital ulcerations may have non-recurrent one-time only or no eye involvement at follow-up. A better visual prognosis can be expected for these patients.

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  • Neutrophil and lymphocyte responses to oral Streptococcus in Adamantiades-Behcet’s disease.

    Kurauchi T, Yokota K, Matsuo T, Fujinami Y, Isogai E, Isogai F, Ohtsuki H, Oguma K

    FEMS Immunol Med Microbiol   43 ( 2 )   125 - 131   2005年2月

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  • The prevalence of strabismus and amblyopia in Japanese elementary school children

    T Matsuo, C Matsuo

    OPHTHALMIC EPIDEMIOLOGY   12 ( 1 )   31 - 36   2005年2月

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    記述言語:英語   出版者・発行元:TAYLOR & FRANCIS INC  

    Background: The purpose of this study is to elucidate the prevalence of strabismus and amblyopia in a large population of Japanese elementary school children, from Grade 1 to Grade 6, ages ranging from 6 to 12 years. The School Health Law requires that all pupils in Grade 1 to Grade 6 be examined for vision and eye problems. Visual acuity testing is done by school teachers and eye disease screening by school ophthalmologists. Pupils with suspected ocular diseases are further examined by extramural ophthalmologists and the results reported back to the schools. The schools then summarize and send uncorrected visual acuity and ocular disease incidence, together with other health statistics, to the municipal education committees. The data are forwarded to the Prefecture Governments and finally submitted to the Education Ministry of the Central Government. Both the Prefecture Governments and the Education Ministry publicize the school health statistics on their websites. The prevalence of strabismus and amblyopia remains unknown from these data because both diagnoses are included under the heading, eye diseases.
    Methods: Questionnaires asking about the numbers of children with different types of strabismus and amblyopia were sent to all elementary schools in Okayama Prefecture and the results were summarized.
    Results: The number of children covered by the return of questionnaires was 86,531 (76.4%) of 113,254 total pupils in Grade 1 to Grade 6 in Okayama Prefecture in the year 2003. The total numbers of children with strabismus and amblyopia were 1,112 (1.28%) and 125 (0.14%), respectively. The numbers of children with any type of exotropia and any type of esotropia were 602 (0.69%) and 245 (0.28%), respectively. The major types of strabismus and amblyopia were intermittent exotropia in 109 children (0.12%) accommodative esotropia in 19 children (0.02%), anisometropic amblyopia in 23 children (0.03%), and ametropic amblyopia in 12 children (0.01%). The number of children with strabismus of unknown type was 245 (0.28%) while the number of children with amblyopia of unknown type was 81 (0.09%).
    Conclusions: The prevalence rates of strabismus and amblyopia in this population of Japanese elementary school children were lower than those reported in Western countries. The exotropia/esotropia ratio were increased in comparison with past studies in Japan. The school eye doctors need to be more diligent in identifying and diagnosing various types of strabismus and amblyopia in order to contribute to the school vision screening program already in place in Japan.

    DOI: 10.1080/092865804909007805

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  • Vitrectomy and silicone oil tamponade as an initial surgery for retinal detachment after acute retinal necrosis syndrome

    T Matsuo

    OCULAR IMMUNOLOGY AND INFLAMMATION   13 ( 1 )   91 - 94   2005年2月

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    記述言語:英語   出版者・発行元:TAYLOR & FRANCIS INC  

    Purpose: To show the feasibility of vitrectomy and silicone oil tamponade as an initial surgical procedure for retinal detachments with multiple tears that develop after the fulminant type of acute retinal necrosis syndrome. Methods: In a prospective noncomparative interventional case series, vitrectomy, silicone oil tamponade, and encircling scleral buckling with a solid silicone, combined with phacoemulsification and intraocular lens implantation (except for one pseudophakic patient [Case 2]), were performed in three consecutive patients during the four-year period from 1999 to 2002. These patients had developed retinal detachment with multiple retinal tears after the resolution of acute retinal necrosis syndrome. As an initial standard treatment for acute retinal necrosis syndrome, all patients received maximum-dose intravenous acyclovir (1500 mg daily) for two weeks combined with intravenous prednisolone tapered from 200 mg daily. Results: Case 1 was a 65-year-old woman who developed retinal detachment 44 days after the onset of acute retinal necrosis syndrome; Case 2, a 79-year-old man, developed retinal detachment 51 days after the onset; and Case 3, a 59-year-old man, developed retinal detachment 70 days after the onset. Before surgery, all patients showed multiple tears scattered on the detached atrophic retina extending over the entire midperipheral fundus with vitreoretinal adhesions and vitreous opacity. The retina was reattached during the initial surgery. The patients showed no recurrence of retinal detachment and maintained a visual acuity of 20/200 or 20/100 during the one- to three-year follow-up period. Conclusions: Vitrectomy and silicone oil tamponade could be a treatment option as the initial surgical procedure for retinal detachments that develop after the fulminant type of acute retinal necrosis syndrome.

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  • Photoelectric dye-coupled polyethylene film as a prototype of retinal prostheses

    A Uji, T Matsuo, S Ishimaru, A Kajiura, K Shimamura, H Ohtsuki, Y Dan-oh, S Suga

    ARTIFICIAL ORGANS   29 ( 1 )   53 - 57   2005年1月

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    記述言語:英語   出版者・発行元:BLACKWELL PUBLISHING INC  

    Photoelectric dyes, which absorb light and convert photon energy to electric potentials, have been previously shown to stimulate retinal neurons in culture. In this study, a photoelectric dye was coupled to a polyethylene film surface and tested in vitro using retinal tissues from chick embryos at the 12-day embryonic stage, at which time outer segments of retinal photoreceptor cells have not yet developed. Carboxyl moieties were introduced to a polyethylene film surface by fuming nitric acid, and then a photoelectric dye, 2-[2-[4-(dibutylamino)phenyl]ethenyl]-3-carboxymethylbenzothiazolium bromide, was coupled to the film through amide linkage. Intracellular calcium elevation was observed with Fluo-4 in retinal tissues placed on the dye-coupled polyethylene film, in contrast to retinal tissues which had no contact with the film. The response was inhibited by calcicludine, a voltage-gated calcium channel blocker, and also by extracellular calcium depletion. The photoelectric dye, coupled to the polyethylene film surface, absorbed light under a dissecting microscope and stimulated neurons in retinal tissues, showing that the dye-coupled film could be used as a prototype of retinal prostheses.

    DOI: 10.1111/j.1525-1594.2004.29010.x

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  • 血液・腫瘍科「眼科付属器に発生するリンパ腫の管理と長期予後」

    松尾俊彦

    血液・腫瘍科   51,485-496   2005年

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  • Cyclic tetrasaccharide delays cataract formation in the lens in vitro

    Toshihiko Matsuo

    Cell Preservation Technology   3 ( 4 )   238 - 243   2005年

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    記述言語:英語  

    The aim of this study was to test whether cyclic tetrasaccharide could prevent cataract formation in isolated porcine lenses in vitro. Porcine eyes were cut at the midperiphery with a razor blade and pressure was applied to the globe to eject the lens without touching. The isolated lenses were then washed with saline and transferred with a spoon to wells of a 24-well multidish with a lid. The lenses were incubated in saline, 1, 10, 20, 50, 75, and 100 mM trehalose or cyclic tetrasaccharide in saline for 40 days at room temperature and in room humidity. Solution change or aeration was not done during the period. The lenses were observed with a dissecting microscope with transmitting light source and the images of the lenses were captured through a CCD camera into a computer. The lens opacity was measured as mean density in a circle area placed inside the lens. Cyclic tetrasaccharide at 75 mM and 100 mM concentrations significantly delayed the development of lens opacity compared with saline, trehalose at any concentrations, and cyclic tetrasaccharide at 50 mM or lower concentrations over the course of 40 days. The lenses in 100 mM cyclic tetrasaccharide showed transient surface opacity on the initial phase of incubation up to 5 days and then became transparent. In conclusion, cyclic tetrasaccharide delays the development of lens opacity in vitro. Cyclic tetrasaccharide might be used as a cataract-delaying agent. © Mary Ann Liebert, Inc.

    DOI: 10.1089/cpt.2005.3.238

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  • 臨床眼科「眼科における最新医工学 Ⅱ.視機能再生工学(3) 光電変換色素を使った人工網膜試作品の開発 -岡山大学方式の人工網膜ー」

    松尾俊彦

    臨床眼科   59,118-122   2005年

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  • 消化器と臨床「難治性クローン病の合併症と対応 眼科領域合併症:虹彩炎などへの対策」

    松尾俊彦

    消化器と臨床   8,443-449   2005年

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  • Systemic malignant lymphoma 17 years after bilateral orbital pseudotumor

    T Matsuo, Y Sato, R Kuroda, N Matsuo, T Yoshino

    JAPANESE JOURNAL OF OPHTHALMOLOGY   48 ( 5 )   503 - 506   2004年9月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE INC  

    Purpose: To report a patient who developed systemic malignant lymphoma 17 years after bilateral orbital pseudotumor.
    Case: A 24-year-old man developed bilateral orbital pseudotumor. He was stable until 17 years later, when he was afflicted with systemic malignant lymphoma, a diffuse large B-cell lymphoma, and he died of the disease. He showed no new orbital lesion at the presentation of systemic lymphoma. Pathological diagnosis at autopsy was systemic malignant lymphoma with bilateral orbital pseudotumor.
    Methods: Immunohistochemical reexamination of the paraffin-embedded tissue and polymerase chain reaction of paraffin sections.
    Results: Histopathologically, the orbital masses resected on different occasions consisted of small lymphocytes and plasma cells. Immunohistochemical staining revealed an immunoglobulin light chain K and lambda bitype of B-cell lymphocytes and plasma cells. In contrast, the cervical lymph node showed large lymphoma cells that were positive only for lambda light chain, indicative of a lambda monotype. Amplification by polymerase chain reaction of the immunoglobulin heavy chain gene from paraffin sections demonstrated clonal rearrangement in the cervical lymph node but showed no clonality in the orbital tumor, supporting altogether the diagnosis of orbital pseudotumor.
    Conclusion: Orbital pseudotumor should be carefully followed for possible development of systemic malignant lymphoma. (C) Japanese Ophthalmological Society 2004.

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  • Trehalose versus hyaluronan or cellulose in eyedrops for the treatment of dry eye

    T Matsuo

    JAPANESE JOURNAL OF OPHTHALMOLOGY   48 ( 4 )   321 - 327   2004年7月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE INC  

    Purpose: Trehalose eyedrops were found by a previous study to be safe and effective compared with saline in the treatment of moderate-to-severe dry eye syndrome. The present study was designed to compare the efficacy of trehalose eyedrops with that of the commercially available eyedrops containing hyaluronan or cellulose now used in the treatment of moderate-to-severe dry eye syndrome.
    Methods: In a randomized, double-masked, 4-week crossover, controlled clinical trial, 36 patients with moderate-to-severe dry eye syndrome were divided into two groups: the hyaluronan (Hyalein)comparison group (18 patients) and the hydroxyethylcellulose (Mytear)-comparison group (18 patients). Each group used either trehalose or one of the commercially available medications contained in a masked eyedrop container for the first 4 weeks, and then for the second 4 weeks, switched to either trehalose or the commercial eyedrop not used for the first 4 weeks. Symptoms and signs in both eyes were recorded at the baseline, at 4 weeks, and at 8 weeks.
    Results: At 4 weeks after the treatment, fluorescein and rose bengal staining scores of the ocular surface as well as the tear film breakup time had improved significantly with trehalose eyedrops compared with the commercially available eyedrops containing either hyaluronan or hydroxyethyleellulose (P < 0.001, Wilcoxon signed ranks test). In addition, all the objective signs were significantly better in patients who finished with trehalose at the end of the 8-week trial compared with those who finished with either of the two commercially available drugs. A larger number of patients evaluated trehalose as a better treatment than the commercially available eyedrops.
    Conclusions: Trehalose solution was a better treatment for moderate-to-severe dry eye syndrome in comparison with two commercially available eyedrops containing hyaluronan or hydroxyethylcellulose. (C) Japanese Ophthalmological Society 2004

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  • Long-term follow-up results of observation or radiation for conjunctival malignant lymphoma

    T Matsuo, T Yoshino

    OPHTHALMOLOGY   111 ( 6 )   1233 - 1237   2004年6月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE INC  

    Purpose: To elucidate the long-term prognosis of biopsy-proven malignant lymphoma of conjunctival origin after a treatment option of observation or radiation.
    Design: Prospective noncomparative interventional case series.
    Participants: Thirteen patients with extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) of conjunctival origin.
    Methods: In the 11-year period from 1992 to 2002, 13 consecutive patients (7 female and 6 male) with ages ranging from 32 to 68 years (mean, 57) who showed malignant lymphoma of conjunctival origin were enrolled in the study. Histopathological and immunohistochemical studies of biopsy specimens of the conjunctival lesions proved extranodal marginal zone B-cell lymphoma of MALT in all patients. At the initial visit, magnetic resonance imaging (MRI) showed no orbital tumors, and gallium scintigraphy demonstrated no systemic involvement. The patients chose observation or radiation after the biopsy.
    Main Outcome Measures: Clinical disappearance of the conjunctival lymphoma lesions.
    Results: Five patients chose 30-Gy radiation to the remaining conjunctival lesions after the biopsy, whereas the other 8 patients were simply observed without administration of any medication. During the follow-up, ranging from 1 to 11 years (mean, 5.4), 7 of these 8 patients without radiation showed spontaneous regression of the conjunctival lesions 1 to 5 years after the biopsy. Yearly MRI of the orbit and gallium scintigraphy disclosed no lesions in any of the patients.
    Conclusions: A large fraction of patients with MALT lymphoma of conjunctival origin had spontaneous regression after the biopsy. Follow-up without radiation is an option for patients with MALT lymphoma of conjunctival origin after the pathologic diagnosis by biopsy. (C) 2004 by the American Academy of Ophthalmology.

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  • Clinical relevance of optineurin sequence alterations in Japanese glaucoma patients

    Tomoko Umeda, Toshihiko Matsuo, Mikio Nagayama, Naoyuki Tamura, Yuko Tanabe, Hiroshi Ohtsuki

    Ophthalmic Genetics   25 ( 2 )   91 - 99   2004年6月

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    記述言語:英語  

    Purpose: To study the clinical relevance of sequence alterations in the optineurin gene (OPTN) among Japanese patients with open-angle glaucoma, including both primary open-angle glaucoma (POAG) and normal tension glaucoma (NTG). Methods: Genomic DNA was isolated from 83 patients with open-angle glaucoma (55 with POAG and 28 with NTG) and 58 control subjects. The 13 exons of OPTN corresponding to the coding region were amplified by polymerase chain reaction and directly sequenced. Clinical factors were compared between glaucoma patients with and without a certain nucleotide change. Results: The reported heterozygous mutations, c.458G &gt
    A(Glu50Lys) in exon 4 and c.691_692insAG in exon 6, were not found in any glaucoma patients or control subjects. The reported c.603T &gt
    A(Met98Lys) in exon 5 was significantly more prevalent in the POAG (8/55, 14.5%, p = 0-0147) and NTG (4/28, 14.2%, p = 0-0369) patients, and even in both the POAG and NTG patients combined (12/83, 14-4%, p = 0.0149, Fisher exact probability test), than in the control subjects (1/58, 1.7%). The rates of the reported c.1944G &gt
    A(Arg545Gln) in exon 16 were not significantly different between open-angle glaucoma patients (3/83, 3.6%) and control subjects (4/58, 6.8%). In addition, a heterozygous change, c.412G &gt
    A(Thr34Thr) in exon 4 was found in 18 (21.6%) open-angle glaucoma patients and seven (12.0%) control subjects. Another heterozygous change, c.457C &gt
    T(Thr49Thr), in exon 4 was found only in three POAG patients. The 18 open-angle glaucoma patients with c.412G &gt
    A showed significantly larger cup-to-disc ratios (p = 0-0178, Mann-Whitney U test), significantly more deteriorated mean deviations of the visual field in the left eye at the final visit (p = 0.0076), and a significantly higher rate of surgery and/or laser history (p = 0.0321, Fisher exact probability test) than the 65 open-angle glaucoma patients without the nucleotide change. Conclusions: Met98Lys is a risk-associated alteration for open-angle glaucoma, including POAG and NTG, in the Japanese population as initially reported. The amino acid-preserving polymorphism, c.412G &gt
    A, may be a genetic risk factor for the progression of open-angle glaucoma in this Japanese population.

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  • ARIX gene polymorphisms in patients with congenital superior oblique muscle palsy

    T Matsuo, Y Jiang, H Fujiwara, S Hasebe, H Ohtsuki, T Yasuda

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   45   U560 - U560   2004年4月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:ASSOC RESEARCH VISION OPHTHALMOLOGY INC  

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  • 岡山県内の小学校児童における斜視および弱視の頻度

    松尾俊彦

    学校保健おかやま   31,1-4   2004年

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  • Prostaglamdins F2α and E2 in aqueous humor of patients with cataract surgery

    Matsuo T

    J Ocular Phamacology and Therapeutics   2004年

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  • 臨床眼科「白内障手術の傾向と対策 ―術中・術後合併症と難治症例Ⅲ.ハイリスク症例 ―私はこうするアトピー性白内障」

    松尾俊彦

    臨床眼科   58,250-253   2004年

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  • 梅毒による続発緑内障

    松尾俊彦

    Frontiers in Glaucoma   5,48-49   2004年

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  • 交感性眼炎

    松尾俊彦

    臨牀看護   30,857-859   2004年

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  • Different levels of TIMPs and MMPs in human lateral and medial rectus muscle tissue excised from strabismic patients

    Mizue Kitada, Toshihiko Matsuo, Takashi Yamane, Satoshi Hasebe, Hiroshi Ohtsuki

    Strabismus   11 ( 3 )   145 - 155   2003年9月

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    記述言語:英語  

    PURPOSE: To arrive at an understanding of the differences in gene and protein expression between human lateral and medial rectus muscle tissue excised from strabismic patients. METHODS: Resected fragments of the lateral and medial rectus muscles obtained during strabismus surgery were frozen under liquid nitrogen and pulverized by a Freezer/Mill system. Radiolabelled cDNA was synthesized from polyA+ RNA and hybridized with a gene array nylon membrane (Atlas Human 1.2 Array) to detect the difference in gene expression between the lateral and medial rectus muscles. Based on the gene array results, tissue inhibitor of metalloproteinases (TIMP)-1 and 2, matrix metalloproteinase (MMP)-2, and bone morphogenetic protein (BMP)-4 were measured in solubilized muscle tissues by enzyme immunoassay and normalized by unit length of resection. RESULTS: The resected lateral rectus muscle had significantly smaller amounts of TIMP-1,TIMP-2 and BMP-4 but larger amounts of MMP-2 compared to the medial rectus muscle (P &lt
    0.001, Mann-Whitney U test).The amounts of TIMP-1 in the muscle when the lateral and medial rectus were combined were positively correlated with TIMP-2 and BMP-4, while the amounts of TIMP-2 positively correlated with BMP-4 (P &lt
    0.001, Spearman rank correlation test). The amounts of BMP-4 in both muscles increased significantly with age (P = 0.0003). CONCLUSIONS: Resected tissue from the lateral and medial rectus muscles had different levels of expression of TIMP-1 and 2, MMP-2, and BMP-4. These molecular differences may underlie different characteristics of the two extraocular muscles and may also influence the process of wound healing after strabismus surgery.

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  • Protein expression, genomic structure, and polymorphisms of oculomedin

    Nagako Fujiwara, Toshihiko Matsuo, Hiroshi Ohtsuki

    Ophthalmic Genetics   24 ( 3 )   141 - 151   2003年9月

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    記述言語:英語  

    Purpose: To elucidate protein expression, genomic structure, and genomic polymorphisms of a novel gene, 'oculomedin', that has been cloned as a mechanical stretch-response gene from human trabecular cells in culture. Methods: Polyclonal antibody was prepared by immunizing rabbits with a chemically synthesized 15-mer peptide of oculomedin. Protein expression was revealed by Western blot analysis after polyacrylamide gel electrophoresis of extracts of mechanically stretched trabecular cells and control trabecular cells in culture as well as retinal tissue. Protein localization was studied immunohistochemically in the human eye section. Genomic structure was determined by searching the GenBank database. Genomic polymorphisms of the coding region in 163 glaucoma patients and 50 normal subjects were detected by PCR amplification and direct sequencing. Results: Western blot analysis showed that oculomedin protein was expressed only in stretched trabecular cells, not in control trabecular cells in culture. Immunohistochemically, oculomedin protein was localized to the trabecular meshwork, Schlemm's canal endothelium, retinal photoreceptor cells, and corneal and conjunctival epithelium. The oculomedin gene (OCLM) consists of two exons which are located inside an intron of a different gene of unknown function (C1orf27) on chromosome 1q25, near and telomeric to myocilin (MYOC). Two types of heterozygous nucleotide substitutions resulting in amino acid changes were found in two of 75 patients with primary open-angle glaucoma, but not at all in patients with other types of glaucoma or in normal subjects. Conclusions: Oculomedin may play a role in the function of the trabecular meshwork and also in the development of primary open-angle glaucoma.

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  • Clinical correlations of aggrecan in the resected medial rectus muscle of patients with intermittent exotropia

    T Yamane, T Matsuo, S Hasebe, H Ohtsuki

    ACTA MEDICA OKAYAMA   57 ( 4 )   199 - 204   2003年8月

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    記述言語:英語   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    The purpose of this study was to elucidate the role of extracellular matrix components such as aggrecan, fibronectin, and laminin in the extraocular muscle of patients with strabismus. Resected tissues of the medial rectus muscle of 47 patients with intermittent exotropia obtained during recession-resection surgery were frozen under liquid nitrogen and pulverized by a Freezer/Mill to solubilize the tissue for enzyme immunoassay. The total amounts of aggrecan, fibronectin, and laminin in the resected tissue were correlated with clinical data of patients such as age, exodeviation, and refractive error. The amount of aggrecan decreased significantly with the advance of age (P < 0.0001, Spearman rank correlation test), while the amount of laminin or fibronectin had no correlation with age. Patients with basic type intermittent exotropia showed larger, although not significantly, amounts of aggrecan than those with convergence insufficiency type (P = 0.0538, Mann-Whitney U-test). The amount of aggrecan may be related to motor aspects of intermittent exotropia.

    DOI: 10.18926/AMO/32803

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  • A simple method for screening photoelectric dyes towards the use for retinal prosthesis

    T Matsuo

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   44   U701 - U701   2003年5月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:ASSOC RESEARCH VISION OPHTHALMOLOGY INC  

    DOI: 10.18926/AMO/32824

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  • Genome-wide search for comitant strabismus susceptibility loci

    H Fujiwara, T Matsuo, M Sato, T Yamane, M Kitada, S Hasebe, H Ohtsuki

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   44   U44 - U44   2003年5月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:ASSOC RESEARCH VISION OPHTHALMOLOGY INC  

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  • Clinical features of comitant strabismus related to family history of strabismus or abnormalities in pregnancy and delivery

    Y Taira, T Matsuo, T Yamane, S Hasebe, H Ohtsuki

    JAPANESE JOURNAL OF OPHTHALMOLOGY   47 ( 2 )   208 - 213   2003年3月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE INC  

    Purpose: To elucidate the genetic or environmental background for clinical features in the three major types of comitant strabismus.
    Methods: Interview based on a questionnaire asking background factors such as family history of strabismus and abnormalities in pregnancy and delivery was conducted with 101 consecutive patients with infantile esotropia (5-180 months of age), 83 with accommodative or partially accommodative esotropia (6-201 months of age), and 143 with intermittent exotropia (3-216 months of age) seen during 7 months from May to November 1998. The clinical features of strabismus obtained from medical records were analyzed statistically by logistic regression to determine their relation with these background factors.
    Results: In infantile esotropia, patients with family history of strabismus had a significantly higher chance of showing latent nystagmus (odds ratio, 3.553; 95% confidence interval [CI], 1.077-11.717; P=.0373, logistic regression analysis). In a subgroup of 40 patients with infantile esotropia whose birth followed no abnormalities in pregnancy or delivery, patients with family history of strabismus had a significantly higher chance of showing inferior oblique muscle overaction (odds ratio, 7.714; 95% CI, 1.246-47.761; P=.0280), dissociated vertical deviation (odds ratio, 6.667; 95% CI, 1.176-37.787; P=.0321), and latent nystagmus (odds ratio, 7.333; 95% CI, 1.168-46.060; P=.0336). In accommodative or partially accommodative esotropia and intermittent exotropia, no relation was found between the clinical features and the background factors.
    Conclusions: Inferior oblique muscle overaction, dissociated vertical deviation, and latent nystagmus in infantile esotropia might have a genetic background.

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  • 眼感染症診療ガイド Ⅱ.診断治療のポイント ぶどう膜・網膜 梅毒性ぶどう膜炎

    松尾俊彦

    臨床眼科   57,191-194   2003年

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  • Long-term visual outcome in primary microtropia

    T Matsuo, Y Kawaishi, R Kuroda, H Ohtsuki, Y Watanabe

    PROGRESS IN STRABISMOLOGY   169 - 171   2003年

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    記述言語:英語   出版者・発行元:SWETS AND ZEITLINGER B V  

    To elucidate the long-term visual outcome of primary microtropia, a retrospective review was made on 31 patients with 5 years or more (5-16 years, mean: 9.2 years) follow-up. All patients showed anomalous retinal correspondence, peripheral fusion, 10 prism diopters or smaller esodeviation at the initial and final visit. At the initial visit, TNO stereoacuity was absent in 25 patients, 480 seconds in 2, and 240 seconds in 4. The visual acuity was 20/20 or better in both eyes of 16 patients, but 20/30 or worse in either eye or both eyes of 15 patients. At the final visit, the 25 patients with no stereoacuity still showed no stereoacuity while stereoacuity remained unchanged or got better in the 6 patients with initial stereoacuity of 480 seconds or better. The visual acuity in 7 of the 15 patients with 20/30 or worse became 20/20 or better while remained 20/30 or worse in the other 8 patients. No relation was found between no TNO stereoacuity and poor visual acuity. Patients with primary microtropia could be largely classified into those with no stereoacuity throughout the course and those with some levels of stereoacuity which had a chance to get better during the follow-up.

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  • 眼感染症診療ガイド Ⅱ.診断治療のポイント ぶどう膜・網膜 HTLV-Ⅰ関連ぶどう膜炎

    寺石友美子, 松尾俊彦

    臨床眼科   57,226-229   2003年

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  • Multiple sclerosis-like disease secondary to alpha interferon

    Toshihiko Matsuo, Ryu Takabatake

    Ocular Immunology and Inflammation   10 ( 4 )   299 - 304   2002年12月

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    記述言語:英語  

    Purpose: To describe bilateral optic neuritis that occurred as an adverse effect of recombinant and natural interferon α administration. Methods: Report of two cases. Case 1, a 62-year-old woman, developed bilateral optic neuritis with decreased sensation of vibration and increased deep tendon reflex in the lower extremities after a seven-month use of recombinant interferon α-2a for chronic active hepatitis C. Case 2, a 29-year-old woman, developed bilateral optic neuritis combined with numbness of the lower extremities as well as bowel and bladder dysfunction after a 22-month use of recombinant interferon α-2b for chronic myelogenous leukemia. After a two-month interruption of interferon administration, natural interferon α was given but followed by another episode of the same neurological manifestations. Results: In both cases, magnetic resonance imaging demonstrated multiple small high-intensity areas in the cerebral white matter and spinal cord, while cerebrospinal fluid examination disclosed mononuclear cell increase and protein elevation including myelin basic protein, all of which simulated the features of multiple sclerosis. The two patients underwent several courses of pulse corticosteroid therapy, each course consisting of three days of methylprednisolone 1000 mg daily, resulting in visual recovery to some extent. Conclusions: Optic neuritis in combination with other neurological signs, simulating multiple sclerosis, should be included in the list of adverse effects of recombinant and natural interferon α administration.

    DOI: 10.1076/ocii.10.4.299.15588

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  • Trehalose eye drops in the treatment of dry eye syndrome

    T Matsuo, Y Tsuchida, N Morimoto

    OPHTHALMOLOGY   109 ( 11 )   2024 - 2029   2002年11月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE INC  

    Objective: Trehalose can protect human corneal epithelial cells in culture from death from desiccation. This study was designed to test the efficacy and safety of trehalose eyedrops in the treatment of moderate to severe dry eye syndrome.
    Design: A randomized, double-masked, dose-ranging, fellow eye-controlled clinical trial.
    Participants: Thirty-four patients with moderate to severe dry eye syndrome.
    Methods: The patients used either 100 or 200 mM trehalose dissolved in saline six times daily in one eye and control saline in the other eye for 4 weeks.
    Main Outcome Measures: Symptoms and signs in both eyes were recorded separately at baseline, 2 weeks, and 4 weeks.
    Results: Fluorescein and rose bengal staining scores of the ocular surface improved at both 2 weeks and 4 weeks in the eyes with 100 and 200 mM trehalose, compared with eyes with control saline (P = 0.0030 to P < 0.0001, respectively, Mann-Whitney U test). Tear film breakup time became significantly longer at 2 weeks and 4 weeks with 100 mM trehalose (P = 0.0024 and P < 0.0001, respectively), but not with 200 mM trehalose. No adverse effect attributable to trehalose solution was noted.
    Conclusions: Trehalose solution was an effective and safe eyedrop for the treatment of moderate to severe dry eye syndrome in this group of patients. (C) 2002 by the American Academy of Ophthalmology, Inc.

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  • Frosted branch angiitis associated with Harada disease-like manifestations recurs 10 years later

    T Matsuo, N Kanata, M Itami

    JAPANESE JOURNAL OF OPHTHALMOLOGY   46 ( 6 )   682 - 684   2002年11月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE INC  

    Purpose: To describe a case with frosted branch angiitis occurring in association with manifestations of Harada disease.
    Case: A 41-year-old man developed marked iridocyclitis, frosted branch angiitis and retinal white dots, together with serous detachment of the sensory retina in the posterior pole of both eyes.
    Observations: Fluorescein angiography demonstrated multiple retinal pigment epithelial leakage points in the early phase followed by late dye pooling in the serous detachment, consistent with the manifestations of Harada disease. The patient experienced recurrence of the same combination of manifestations 10 years later. On both occasions, he showed mononuclear cell increase and protein elevation in the cerebrospinal fluid on spinal tap.
    Conclusion: Fluorescein angiography and spinal tap supported the diagnosis of Harada disease in the patient. The present patient could be diagnosed as having either Harada disease with frosted branch-like response or frosted branch angiitis with serous retinal detachment as occurs in Harada disease. (C) 2000 Japanese Ophthalmological Society.

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  • Seropositivity of human herpesvirus-8 in patients with uveitis

    Toshihiko Matsuo, Masako Itami

    Ocular Immunology and Inflammation   10 ( 3 )   197 - 199   2002年9月

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    記述言語:英語  

    Purpose: To explore the role of human herpesvirus-8 (HHV-8) in the pathogenesis of uveitis and other forms of ocular inflammation. Methods: Serum antibody titers to HHV-8 were measured in 76 patients with uveitis from various causes and other types of ocular inflammation in either the acute phase, the convalescent phase, or both. Results: Only one 21-year-old male patient in the convalescent phase of unilateral pars planitis showed a positive titer for HHV-8. His serum was negative for human immunodeficiency virus-1. Conclusions: Although the seropositive rate in the patient population was higher than that in the general population, the increased incidence was not statistically significant. The role of HHV-8 in the pathogenesis of intraocular inflammation appears to be limited.

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  • Choroidal Neovascularization occurring concurrently in myopic eyes of monozygotic twins

    T Matsuo, J Seguchi, F Shiraga, Y Takesue, N Sakaguchi

    OPHTHALMOLOGICA   216 ( 4 )   281 - 283   2002年7月

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    記述言語:英語   出版者・発行元:KARGER  

    Purpose: To present young monozygotic twins both of whom developed choroidal neovascularization at the same time. Case/Observations: Monozygotic twins, 22-year-old women, who lived in the same house, developed choroidal neovascularization in the left eye at the same time. The degree of myopia was higher in the left eye (-7.75 and -8.5 dpt in spherical equivalent) than in the right eye (-6.75 and -4.5 dpt) of both patients. The choroidal neovascularization regressed in a different time course and the visual acuity returned to normal in both patients. Conclusion: This pair of monozygotic twins suggests that both genetic and environmental factors underlie the development of choroidal neovascularization in myopic eyes. Copyright (C) 2002 S. Karger AG, Basel.

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  • Risk factors for diabetic choroidopathy in patients with diabetic retinopathy

    C Shiragami, F Shiraga, T Matsuo, Y Tsuchida, H Ohtsuki

    GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY   240 ( 6 )   436 - 442   2002年6月

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    記述言語:英語   出版者・発行元:SPRINGER-VERLAG  

    Purpose: To identify risk factors for diabetic choroidopathy in patients with type 2 diabetes. Methods: Forty-five consecutive patients with diabetic retinopathy underwent simultaneous indocyanine green angiography (ICG) and fluorescein angiography using a double detector and confocal scanning laser ophthalmoscopy in both eyes. Choroidal vascular abnormalities were evaluated by comparing the angiographic findings derived from the two methods. We analyzed the association between the presence of abnormal choroidal lesions evident on ICG angiography and several risk factors. Results: Choroidal abnormalities evident on ICG angiography but not on fluorescein angiography included hypofluorescent spots in 72 eyes (80%) of 40 patients (89%), small hyperfluorescent spots in 61 eyes (68%) of 35 patients (78%), and large hyperfluorescent spots in 32 eyes (36%) of 21 patients (47%). The severity of diabetic retinopathy was significantly associated with the presence of hypofluorescent spots (P=0.002, Cochran-Armitage test) in both eyes and with the small hyperfluorescent spots in the right eyes (P=0.047, Cochran-Armitage test). Glycosylated hemoglobin levels were significantly associated with the large hyperfluorescent spots in the right eyes (P=0.003, Fisher's exact probability test), and the treatment regimen was significantly associated with the small hyperfluorescent spots in the left eyes (P=0.048, chi-square test). Conclusion: These data suggest that risk factors influencing the prevalence of diabetic choroidopathy in patients with type 2 diabetes mellitus may include severity of diabetic retinopathy, degree of diabetic control and treatment regimen.

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  • Submacular exudates with serous retinal detachment caused by cat scratch disease

    Toshihiko Matsuo, Mutsuko Kato

    Ocular Immunology and Inflammation   10 ( 2 )   147 - 150   2002年6月

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    記述言語:英語  

    Purpose: To present submacular exudates as a manifestation of cat scratch disease. Methods: Report of two cases. Results: The first patient, a 34-year-old man, developed submacular exudates with serous retinal detachment ten days after having axillary lymphadenopathy and fever. The second patient, a 30-year-old woman, developed submacular exudates with serous retinal detachment mimicking central serous chorioretinopathy. Fluorescein angiography revealed late staining of the subretinal lesions in both cases. The lesion resolved spontaneously in the first patient, while sulfamethoxazole and trimethoprim was required for the second patient. Both patients had a positive IgG titer for Bartonella henselae. Conclusions: Submacular exudates with serous retinal detachment can occur in cat scratch disease. Cat scratch disease should be included in the differential diagnosis of submacular exudates with central serous chorioretinopathy.

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  • Acute posterior Multifocal placoid pigment epitheliopathy and scleritis in a patient with pANCA-positive systemic vasculitis

    T Matsuo, T Horikoshi, C Nagai

    AMERICAN JOURNAL OF OPHTHALMOLOGY   133 ( 4 )   566 - 568   2002年4月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE INC  

    PURPOSE: To present acute posterior multifocal placoid pigment epitheliopathy and scleritis occurring in association with pANCA (perinuclear antineutrophil cytoplasm mic antibody),positive systemic vasculitis.
    DESIGN: Interventional case report.
    METHODS: A 69-year old woman developed bilateral acute posterior multifocal placoid pigment epitheliopathy concurrent with rapidly progressive glomerulonephritis and bronchioalveolitis in both lungs.
    RESULTS: The patient showed a high titer of pANCA (myeloperoxidase,ANCA). She then developed scleritis in the left eye and multiple gastric ulcers.
    CONCLUSION: Acute posterior multifocal placoid pigment epitheliopathy and scleritis in this patient are manifestations that are part of pANCA-positive systemic vasculitis. This association further supports that acute posterior multifocal placoid pigment epitheliopathy is caused by vasculitic inflammation of the choriocapillaris. (C) 2002 by Elsevier Science Inc. All rights reserved.

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  • The incidence and pathology of conjunctival ulceration in Behcet's syndrome

    T Matsuo, M Itami, H Nakagawa, M Nagayama

    BRITISH JOURNAL OF OPHTHALMOLOGY   86 ( 2 )   140 - 143   2002年2月

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    記述言語:英語   出版者・発行元:BRITISH MED JOURNAL PUBL GROUP  

    Aims: To describe the results of a study of the incidence of conjunctival ulceration and its pathology as a manifestation of Behcet's syndrome.
    Methods: The authors reviewed retrospectively medical charts of 152 patients with Behcet's syndrome seen at the uveitis service of Okayama University Hospital from January 1995 to December 1999. Criteria used to diagnose Behcet's syndrome in this study required the presence of oral aphthous ulceration plus any two of three other manifestations-genital ulceration, eye lesions such as iridocyclitis uveoretinitis, or skin lesions such as erythema nodosum. The presence of conjunctival ulceration was determined in patients with Behcet's syndrome through standardised ophthalmological examinations. A biopsy of the conjunctival ulceration was performed in one patient. The incidence of conjunctival ulceration in patients with Behcet's syndrome was calculated and the clinical and pathological features of this ulceration were examined.
    Results: Four of 152 patients (2.6%) developed conjunctival ulceration in concordance with exacerbation of their systemic symptoms. Histopathological examinations of a conjunctival biopsy specimen in one patient revealed intraepithelial and perivascular infiltration with neutrophils and lymphocytes consistent with Behcet's syndrome. The conjunctival ulcerations of the study patients showed good response to topical corticosteroids or topical steroids plus oral colchicine.
    Conclusions: Conjunctival ulceration should be noted as an uncommon but possible manifestation of Behcet's syndrome. Accordingly, routine examination of the conjunctival is recommended in patients with Behcet's syndrome, and Behcet's syndrome should be included in a list of differential diagnoses for patients with conjunctival ulcerations.

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  • Fluorescein angiographic features of tubulointerstitial nephritis and uveitis syndrome

    T Matsuo

    OPHTHALMOLOGY   109 ( 1 )   132 - 136   2002年1月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE INC  

    Objective: To explain fluorescein angiographic features in patients with tubulointerstitial nephritis and uveitis syndrome.
    Design: Retrospective observational case series.
    Participants: Four consecutive patients with tubulointerstitial nephritis and uveitis syndrome seen at Uveitis Service of Okayama University Hospital from 1995 to 2000.
    Methods: Patients' characteristics obtained from medical records were analyzed. In addition, characteristics of 15 patients reported previously as case reports in the Japanese literature were reviewed.
    Main Outcome Measures: Clinical and fluorescein angiographic features.
    Results: The present four patients showed varying degrees of retinal capillary leakage on fluorescein angiography, ranging from capillary leakage limited to the peripheral fundus to cystoid macular edema. The same angiographic features were found in 15 patients reported previously in the Japanese literature.
    Conclusions: Retinal capillary leakage of varying degrees was a common fluorescein angiographic feature in patients with tubulointerstitial nephritis and uveitis syndrome. Fluorescein angiography is valuable in assessing the extent of retinal involvement. (C) 2002 by the American Academy of Ophthalmology.

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  • Concordance of strabismic phenotypes in monozygotic versus multizygotic twins and other multiple births

    T Matsuo, M Hayashi, H Fujiwara, T Yamane, H Ohtsuki

    JAPANESE JOURNAL OF OPHTHALMOLOGY   46 ( 1 )   59 - 64   2002年1月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE INC  

    Purpose: The concordance of strabismic phenotypes was examined in monozygotic versus multizygotic twins and other multiple births to study the role of genetic background in different types of comitant strabismus.
    Methods: Medical charts of 45 consecutive pairs of twins (16 monozygotic and 18 dizygotic twins, and 11 with unknown zygosity), 3 sets of triplets (one monozygotic and 2 trizygotic triplets), and one set of quadruzygotic quadruplets examined at 6 institutions between 1973 and 1999 were reviewed retrospectively. The concordance was defined as both or all members having either esotropia or exotropia in common.
    Results: The concordance of strabismic phenotypes was noted in 33 of 49 pairs or sets (67.3%): 14 of 17 monozygotic twins or triplets (82.4%), 10 of 21 multizygotic twins, triplets, or quadruplets (47.6%), and 9 of 11 twins with unknown zygosity (81.8%). The concordance rate was significantly higher in monozygosity than in multizygosity (P = .043, Fisher exact probability test). The predominant concordant phenotypes in monozygosity were accommodative esotropia and intermittent exotropia.
    Conclusion: A high concordance rate of strabismic phenotypes, predominantly of accommodative esotropia and intermittent exotropia in monozygosity, suggests the genetic background for these types of strabismus. (C) 2002 Japanese Ophthalmological Society.

    DOI: 10.1016/S0021-5155(01)00465-8

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  • Multiple occlusive retinal arteritis in both eyes of a patient with rheumatoid arthritis

    T Matsuo

    JAPANESE JOURNAL OF OPHTHALMOLOGY   45 ( 6 )   662 - 664   2001年11月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE INC  

    Purpose: To report multiple occlusive retinal arteritis as a complication of rheumatoid arthritis.
    Case: A 67-year-old woman developed superotemporal branch retinal artery occlusion in both eyes, together with arterial sheathing and large cotton wool patches around the optic disc, in the course of rheumatoid arthritis with moderate activity.
    Observations: Fluorescein angiography disclosed delayed filling of the superotemporal retinal artery in the right eye and no filling of the superotemporal artery in the left eye, In addition, segmental absence of filling was found in peripheral branches of the other major retinal arteries in both eyes. After hyperbaric oxygen therapy and intravenous administration of prostaglandin E1 and urokinase for 2 weeks, there was improvement in her vision.
    Conclusion: Multiple occlusive retinal arteritis in rheumatoid arthritis can manifest as retinal artery occlusion. Rheumatoid arthritis should be included in the differential diagnosis of bilateral retinal artery occlusion. (C) 2001 Japanese Ophthalmological Society.

    DOI: 10.1016/S0021-5155(01)00410-5

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  • Planned two-step vitrectomy for extremely large and thick subretinal hematoma

    T Matsuo, F Shiraga, Takasu, I

    ACTA OPHTHALMOLOGICA SCANDINAVICA   79 ( 5 )   533 - 537   2001年10月

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    記述言語:英語   出版者・発行元:MUNKSGAARD INT PUBL LTD  

    Purpose: To describe a new surgical strategy, planned two-step vitrectomy, for a large and thick subretinal hematoma involving 3 or more quadrants of the fundus.
    Surgical Methods: In a first-step vitrectomy, a retinotomy was made in the posterior pole, after any vitreous hemorrhage had been removed. Following fluid-gas exchange with no laser photocoagulation around the retinotomy, patients took a face-down position for a few days to a week to facilitate subretinal hemorrhage movement to the vitreous cavity and anterior chamber. In a second-step surgery, the hemorrhage in the vitreous cavity and anterior chamber was washed out. The remaining subretinal hemorrhage was aspirated, and the retina was reattached with fluid-gas exchange and laser photocoagulation around the retinotomy.
    Results: The planned two-step vitrectomy was performed in 4 consecutive patients with large and thick subretinal hematomas involving 3 or more quadrants seen during a 3-year period. By a face-down position after the first-step vitrectomy, subretinal hemorrhage moved to the vitreous cavity and anterior chamber. The remaining subretinal hemorrhage in a smaller quantity could be easily removed, leading to retinal reattachment in the second-step surgery.
    Conclusions: The planned two-step vitrectomy is a safer and more effective procedure for removing a large quantity of subretinal hemorrhage in a shorter period of surgical time, compared with hemorrhage removal in a single vitrectomy.

    DOI: 10.1034/j.1600-0420.2001.790522.x

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  • TIMP-1 production by bovine retinal pigment epithelial cells increases in response to cyclic mechanical stretch

    K Yamaguchi, T Matsuo, F Shiraga, H Ohtsuki

    JAPANESE JOURNAL OF OPHTHALMOLOGY   45 ( 5 )   470 - 474   2001年9月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE INC  

    Purpose: The effect of mechanical stretch was examined on cultured retinal pigment epithelial (RPE) cells in order to observe changes in their production of tissue inhibitor of metalloprotemase-1 (TIMP-1) and vascular endothelial growth factor (VEGF) in response to physiological strain.
    Methods: Bovine RPE cells in near-confluent culture were exposed to mechanical stretch of the bottom of a 6-cm petri dish at the maximum magnitude of 4500 microstrain and at a cycle of 30 seconds for 72 hours. TIMP-1 and VEGF levels in the medium following 24,48, and 72 hours of cyclic stretch were measured by enzyme immunoassay.
    Results: The growth of RPE cells during the 72-hour period of stretching did not show a significant difference from that of nonstretched control cells. RPE cells in the stretched group produced a significantly larger amount of TIMP-1 at 48 and 72 hours after stretch. compared with nonstretched control (P =.044 and P =.027, respectively, Student t-test). The levels of VEGF produced by RPE cells were not significantly different between the stretched group and nonstretched control group.
    Conclusions: The secretion of TIMP-1 by bovine RPE cells was enhanced by cyclic mechanical stretch. Mechanical strain is one factor in regulating the secretion of TIMP-1 by RPE cells. Jpn J Ophthalmol 2001;45:470-474 (C) 2001 Japanese Ophthalmological Society.

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  • Scleral infolding combined with vitrectomy and gas tamponade for retinal detachment with macular holes in highly myopic eyes

    T Matsuo, F Shiraga, Takasu, I, T Okanouchi

    JAPANESE JOURNAL OF OPHTHALMOLOGY   45 ( 4 )   403 - 408   2001年7月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE INC  

    Purpose: To describe the effectiveness of a surgical procedure, scleral infolding combined with vitrectomy and gas tamponade, for retinal detachment caused by macular holes in highly myopic eyes.
    Methods: In a pilot study, scleral infolding was performed in 5 patients with macular holes, who were selected from 10 consecutive highly myopic patients with retinal detachment caused by macular holes (8 patients) or extramacular posterior-pole holes (2 patients), treated during 1 year at Okayama University Hospital. The patients were all women, 48-77 years of age (mean = 63.4 years), who had been followed-up for 1-2 years. Selection criteria for scleral infolding were either second surgeries for reopening of macular holes (2 patients) or residual retinal detachment around macular holes after complete fluid-air exchange with drainage of subretinal fluid at the initial surgery (3 patients). Following vitrectomy and complete epiretinal membrane removal in the posterior pole, the sclera was shortened by infolding on the temporal side. Three mattress sutures with 5-0 Dacron in each quadrant, 6 sutures in total, were placed at a 7-mm anteroposterior interval with posterior sutures located as deep as possible, near vortex veins. Fluid-gas exchange was then done, with or without endophotocoagulation applied around macular holes.
    Results: After scleral infolding, macular holes were closed, and the retina was totally attached in all 5 patients. The final visual acuity ranged from 20/2000 to 20/70.
    Conclusion: Scleral infolding is a simple and effective procedure for treating retinal detachment with macular holes in highly myopic eyes and could be used as an optional procedure of reoperation for a failed initial vitrectomy. Jpn J Ophthalmol 2001;45:403-408 (C) 2001 Japanese Ophthalmological Society.

    DOI: 10.1016/S0021-5155(01)00341-0

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  • Corneal marginal infiltration with ulcerative colitis: A case report

    T Matsuo

    CORNEA   20 ( 4 )   436 - 437   2001年5月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    DOI: 10.1097/00003226-200105000-00022

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  • Trehalose protects corneal epithelial cells from death by drying

    T Matsuo

    BRITISH JOURNAL OF OPHTHALMOLOGY   85 ( 5 )   610 - 612   2001年5月

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    記述言語:英語   出版者・発行元:BRITISH MED JOURNAL PUBL GROUP  

    Aim-This study was designed to examine whether trehalose could protect corneal epithelial cells in culture from death by desiccation in order to test trehalose as a potential new eye drop for dry eye syndrome.
    Methods-Human corneal epithelial cells in near confluent culture in wells of a 96 well multidish were preincubated for 15 minutes with 2, 20, 50, 100, or 200 mM trehalose or maltose in phosphate buffered saline (PBS), PBS alone, or three kinds of commercially available artificial tear substitutes tone with berate buffered saline and the other two containing either hydroxyethylcellulose or hyaluronan). The medium was aspirated completely and cells were left dry for 30 minutes at room temperature in room humidity. Live cells and dead cells were visualised by fluorescent dyes and counted for statistical analysis.
    Results-The percentage of dead corneal epithelial cells after desiccation was significantly lower in preincubation with 50, 100, and 200 mM trehalose, compared with preincubation with PBS alone (p <0.0001, Kruskal-Wallis test, and p <0.05, Tukey-Kramer test). Trehalose at the concentration of 20 mM or lower, maltose at any concentrations, and commercially available artificial tear substitutes did not protect corneal epithelial cells from death by desiccation.
    Conclusions-Trehalose at 50, 100, and 200 mM protected corneal epithelial cells in culture from death by desiccation. Trehalose could be used as a potential new eye drop for dry eye syndrome.

    DOI: 10.1136/bjo.85.5.610

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  • Same eye recurrence of acute retinal necrosis syndrome

    T Matsuo, T Nakayama, T Baba

    AMERICAN JOURNAL OF OPHTHALMOLOGY   131 ( 5 )   659 - 661   2001年5月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE INC  

    PURPOSE: To report same eye recurrence of acute retinal necrosis syndrome.
    METHODS: Two case reports,
    RESULTS: Acute retinal necrosis syndrome recurred in the left eye of a 60-year-old man 13 years after the initial episode, and recurred in the right eye of a 49-year-old woman 8 years after the initial episode, The recurrent necrotic lesions developed in normal appearing retina, unrelated to the location of the previous lesions. The recurrent lesions were successfully treated with acyclovir,
    CONCLUSION: Patients with acute retinal necrosis syndrome should be followed because of possible recurrence not only in the other eye but also in the same eye. (C) 2001 by Elsevier Science Inc, All rights reserved.

    DOI: 10.1016/S0002-9394(00)00847-3

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  • Retinal cells produce TIMP-1 and TIMP-2 in response to cyclic mechanical stretching

    M Namba, T Matsuo, F Shiraga, H Ohtsuki

    OPHTHALMIC RESEARCH   33 ( 3 )   163 - 169   2001年5月

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    記述言語:英語   出版者・発行元:KARGER  

    Purpose: Tissue inhibitors of metalloproteinases (TIMPs) are crucial for the maintenance of retinal extracellular matrix such as interphotoreceptor matrix and internal limiting membrane. This study is to examine whether retinal cells respond to mechanical stretching and produce TIMPs. Methods: Chick retinal adherent cells in near confluency were exposed to mechanical stretching of the bottom of a 6-cm Petri dish at the maximum magnitude of 4,500 microstrain and at a cycle of 30 a for 72 h. TIMP-1 and TIMP-2 levels in the medium at 24, 48 and 72 h after the beginning of stretching were measured by enzyme immunoassay, and their expression was examined by immunohistochemistry. Results: The number of retinal cells during the 72-hour period of stretching did not change significantly both in the stretched group and in the nonstretched control group. Retinal cells in the stretched group produced significantly larger amounts of TIMP-1 and TIMP-2 at 48 h after stretching, compared with nonstretched controls (p = 0.0163 and p = 0.047, respectively, Mann-Whitney U test). Immunohistochemically, a large part of retinal cells in nonstretched Petri dishes was positive for glial fibrillary acidic protein, indicative of glial cells, while some small foci of cells were positive for neuron-specific enolase, indicative of neurons. Fluorescent double labeling demonstrated that both glial cells and neurons were positive for TIMP-1 and TIMP-2, Conclusion: Chick retinal cells, most of which were glial cells mixed with a small number of neurons, produced TIMP-1 and TIMP-2. Their production was enhanced by cyclic mechanical stretching. Copyright (C) 2001 S. Karger AG, Basel.

    DOI: 10.1159/000055664

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  • Ocular attacks after phacoemulsification and intraocular lens implantation in patients with Behcet disease

    T Matsuo, M Takahashi, Y Inoue, K Egi, Y Kuwata, A Yamaoka

    OPHTHALMOLOGICA   215 ( 3 )   179 - 182   2001年5月

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    記述言語:英語   出版者・発行元:KARGER  

    Purpose: To elucidate factors related to ocular inflammatory attacks after cataract surgery, limited to a single procedure of phacoemulsification and intraocular lens implantation, in patients with Behcet disease, Methods: This retrospective study included 12 consecutive patients (16 eyes) with Behcet disease, who underwent phacoemulsification and intraocular lens implantation during 4 years from January 1995 to December 1998 at three institutions, Their medical records were reviewed, and factors related to the ocular attacks were analyzed, Results: Four eyes of 3 patients experienced ocular attacks during 1 year before cataract surgery, while 4 eyes of 4 patients developed ocular attacks during 1 year after the surgery, The development of ocular attacks after cataract surgery was significantly related with the presence of ocular attacks during 1 year before the surgery (p = 0.0286, chi (2) test), The patients' age or gender, the duration of Behcet disease or oral medications for Behcet disease did not show any relationship with the presence or absence of ocular attacks after cataract surgery, The visual acuity improved in all patients after the surgery, including those who developed ocular attacks, Conclusions: The experience of ocular attacks during 1 year before cataract surgery is related to postoperative ocular attacks, Despite postoperative ocular attacks, phacoemulsification with intraocular lens implantation is a safe procedure to expect a good visual outcome in patients with Behcet disease, Copyright (C) 2001 S.Karger AG, Basel.

    DOI: 10.1159/000050854

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  • TIMP-1 production by human scleral fibroblast decreases in response to cyclic mechanical stretching

    A Yamaoka, T Matsuo, F Shiraga, H Ohtsuki

    OPHTHALMIC RESEARCH   33 ( 2 )   98 - 101   2001年3月

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    記述言語:英語   出版者・発行元:KARGER  

    Purpose: The effect of mechanical stretching was examined on cultured scleral fibroblasts of the human eye in order to observe changes in their production of TIMP (tissue inhibitor of metalloproteinase)-1, MMP (matrix metalloproteinase)-1 and -2 in response to physiological strain. Methods: Human scleral fibroblasts were cultured from scleral tissue resected during foveal translocation surgery. The fibroblasts in near confluency were exposed to mechanical stretching of the bottom of a 6-cm Petri dish at the maximum magnitude of 4500 microstrain and at a cycle of 30 s for 72 h, TIMP-1, MMP-1 and MMP-2 levels in the medium following 24, 48 and 72 h of cyclic stretching were measured by enzyme immunoassay. Results: The growth of scleral fibroblasts during the 72-hour period of stretching did not show a significant difference from that of non-stretched control fibroblasts, Scleral fibroblasts in the stretched group produced a significantly smaller amount of TIMP-1 at 72 h after stretching, compared with nonstretched control (p = 0.0353, Student t-test). The levels of MMP-1 and MMP-2 produced by scleral fibroblasts were not significantly different between the stretched group and nonstretched group. Conclusion: The production of TIMP-1 by human scleral fibroblasts was suppressed by cyclic mechanical stretching. Mechanical strain would be one factor to regulate the homeostasis of extracellular matrix in the sclera, Copyright (C) 2001 S. Karger AG, Basel.

    DOI: 10.1159/000055651

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  • Heredity versus abnormalities in pregnancy and delivery as risk factors for different types of comitant strabismus

    T Matsuo, T Yamane, H Ohtsuki

    JOURNAL OF PEDIATRIC OPHTHALMOLOGY & STRABISMUS   38 ( 2 )   78 - 82   2001年3月

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    記述言語:英語   出版者・発行元:SLACK INC  

    Purpose: To elucidate risk factors for different types of comitant strabismus, the incidence of heredity and abnormalities in pregnancy and delivery was compared among different types of strabismus.
    Methods: Between May 1998 and January 1999, a prospective clinical study of 500 consecutive patients with comitant strabismus at a referral-based university hospital was performed using data collected from questionnaires and interviews. Inclusion criteria were infantile esotropia (168 patients) accommodative and partially accommodative esotropia (97 patients), micro-esotropia (15 patients), acquired esotropia (12 patients), intermittent or constant exotropia (205 patients), and congenital exotropia (3 patients). Exclusion criteria were strabismus associated with systemic and central nervous system abnormalities and organic eye diseases.
    Results: Family history was significantly more prevalent in intermittent or constant exotropia and accommodative or partially accommodative esotropia than in infantile esotropia (P<.0001 and P=.0267, respectively, Fisher's exact test). In contrast, abnormalities in pregnancy and delivery were noted at a significantly higher rate in infantile esotropia than in accommodative or partially accommodative and in intermittent or constant exotropia (P=.003 and P=.0215, respectively). Patients with infantile esotropia were significantly younger at the survey than those with the other two types of strabismus (P=.0004 and P<.0001). No significant difference was found in the number of siblings, birthweight, maternal age at delivery, or maternal cigarette smoking or alcohol drinking among these three types of strabismus.
    Conclusion: Heredity and abnormalities in pregnancy and delivery are two major risk factors for comitant strabismus and contribute at different levels to the development of infantile esotropia, accommodative or partially accommodative esotropia, and intermittent or constant exotropia.

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  • 斜視の原因.

    松尾俊彦

    眼科臨床医報   95,40-44   2001年

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  • アトピー白内障の原因:ある眼科医の印象から.

    松尾俊彦

    白内障学会誌   13,32-34   2001年

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  • 緑内障と遺伝子診療.

    松尾俊彦

    Frontiers in Glaucoma   2,30-33   2001年

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  • 両涙腺、両眼外筋肥大がみられた悪性リンパ腫の1例.

    清水敏成, 河野玲華, 松尾俊彦, 大月 洋, 品川克至, 藤原隆行, 吉野 正

    眼紀   2001年

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  • 共同性内斜視の所見と背景因子との関係.

    平 由起, 松尾俊彦, 山根貴司, 河野玲華, 長谷部 聡, 大月 洋

    眼科臨床医報   2001年

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  • 双生児における斜視の表現型の一致について.

    林 瑞恵, 松尾俊彦, 大月 洋, 宮川公博, 横町文子, 豊田英治, 西崎秋子, 馬場哲也, 市川理恵

    眼科臨床医報   2001年

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  • 両眼涙腺、両眼外眼筋肥大がみられた悪性リンパ腫の1例.

    清水敏成, 河野玲華, 松尾俊彦, 大月 洋, 品川克至, 藤原隆行, 吉野 正

    日本眼科紀要   2001年

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  • Endogenous amoebic endophthalmitis

    Toshihiko Matsuo, Kenji Notohara, Fumio Shiraga, Shinya Yumiyama

    Archives of Ophthalmology   119 ( 1 )   125 - 128   2001年

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    記述言語:英語  

    A 42-year-old man experienced abrupt reduction of vision in the left eye and had vitreous opacity and hypopyon on initial examination. He underwent an emergency vitrectomy and phacoemulsification with posterior capsulectomy, followed by a 2-week course of intravenous fluconazole and antibiotics. The final visual acuity was 20/20 OS, Amoebas, together with polymorphonuclear cells, were observed on examination of specimens of the aqueous humor and vitreous fluid obtained during the surgery. Staphylococcus epidermidis was also cultured from the vitreous fluid. The amoebas had a crescent-shaped periphery of the cytoplasm and ambiguous nuclei. Ultrastructurally, the cytoplasm was surrounded by a thick electron-dense coating. The early vitrectomy and combined use of antibiotics and antifungals might have led to the good visual outcome in this patient.

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  • ミヤンマー見聞緑(松尾組の雑記帳 その2)ー病院視察報告ー

    松尾俊彦

    瞳青   2001年

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  • エアバック眼外傷の2例.

    野中文貴, 永山幹夫, 松尾俊彦, 白神史雄, 大月 洋

    臨床眼科   2001年

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  • Isolation of cDNA clones specific to the extraocular muscle of infantile esotropia

    T Yamane, T Matsuo, H Ohtsuki

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   41 ( 4 )   S418 - S418   2000年3月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:ASSOC RESEARCH VISION OPHTHALMOLOGY INC  

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  • In situ visualization of messenger RNA for basic fibroblast growth factor in living cells

    Toshihiko Matsuo

    Biochimica et Biophysica Acta - General Subjects   1379 ( 2 )   178 - 184   1998年2月

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    記述言語:英語   出版者・発行元:Elsevier  

    We examined whether meSsenger RNA for basic fibroblast growth factor (bFGF) could be visualized specifically by a fluorescent probe in living cells. A 15-nucleotide-long antisense or sense sequence for human bFGF was sandwiched between two complementary 5-nucleotide-long arm sequences. A fluorophore, 5-(2'-aminoethyl)aminonaphthalene-1-sulfonic acid (EDANS), was joined to the 5'-terminal phosphate, while 4-(4'- dimethylaminophenylazo)benzoic acid, quencher for EDANS, was joined to the 3'-terminal hydroxyl group. The probe emitted blue fluorescence only upon hybridization with the complementary 18-nucleotide-long sequence under ultraviolet light. The antisense or sense probe carried with liposome was delivered to human cells, trabecular cells of the eye, in a glass-bottom culture dish placed on the stage of an inverted microscope. Cells with the antisense probe did, but not with the sense probe, show blue fluorescense under ultraviolet light. The present study opens a way to measure the changing levels of a specific messenger RNA in living cells.

    DOI: 10.1016/S0304-4165(97)00090-1

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  • Gene transfer to the retina of rat by liposome eye drops

    Toshihiko Matsuo, Ikuya Masuda, Tatsuji Yasuda, Nobuhiko Matsuo

    Biochemical and Biophysical Research Communications   219 ( 3 )   947 - 950   1996年2月

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    記述言語:英語   出版者・発行元:Academic Press Inc.  

    Gene delivery to the intraocular tissues of the retina is hampered by complicated surgical interventions to administer the gene. Here we showed that instillation as eye drops of an expression plasmid vector for beta-galactosidase gene carried by the specific kinds of liposomes could transfer the gene to the retinal ganglion cells of rat, without causing any inflammation. This non-surgical, convenient way for gene delivery to the retina would facilitate the development of treatment for various intraocular diseases.

    DOI: 10.1006/bbrc.1996.0326

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  • Gene transfer to the retina of rat by liposome eye drops

    Toshihiko Matsuo, Ikuya Masuda, Tatsuji Yasuda, Nobuhiko Matsuo

    Biochemical and Biophysical Research Communications   219 ( 3 )   947 - 950   1996年2月

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    記述言語:英語   出版者・発行元:Academic Press Inc.  

    Gene delivery to the intraocular tissues of the retina is hampered by complicated surgical interventions to administer the gene. Here we showed that instillation as eye drops of an expression plasmid vector for beta-galactosidase gene carried by the specific kinds of liposomes could transfer the gene to the retinal ganglion cells of rat, without causing any inflammation. This non-surgical, convenient way for gene delivery to the retina would facilitate the development of treatment for various intraocular diseases.

    DOI: 10.1006/bbrc.1996.0326

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  • Apoptosis regulated by growth factors in multicellular spheroids of trabecular cells

    T Matsuo, N Matsuo

    JAPANESE JOURNAL OF OPHTHALMOLOGY   40 ( 3 )   356 - 366   1996年

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    記述言語:英語   出版者・発行元:JAPAN J OPHTHALMOL  

    Bovine and porcine trabecular cells were incubated up to one month in a polystyrene dish nonadherent environment for suspension culture, and their morphological changes were examined by light and electron microscopy, The trabecular cells formed multicellular spheroids during the first day, Apoptosis occurred selectively and continuously in the spheroids, which had initially been filled with cells, After one month, the final structure of the spheroids had become a meshwork of cells separated by large extracellular spaces, Epidermal and basic fibroblast growth factors prevented apoptosis of the trabecular cells in the spheroids which remained filled with cells for the entire observation period, The trabecular multicellular spheroids may represent the in vitro process of trabecular meshwork formation and can be used as a system for identifying regulatory factors involved in this process.

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  • Apoptosis regulated by growth factors in multicellular spheroids of trabecular cells

    T Matsuo, N Matsuo

    JAPANESE JOURNAL OF OPHTHALMOLOGY   40 ( 3 )   356 - 366   1996年

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    記述言語:英語   出版者・発行元:JAPAN J OPHTHALMOL  

    Bovine and porcine trabecular cells were incubated up to one month in a polystyrene dish nonadherent environment for suspension culture, and their morphological changes were examined by light and electron microscopy, The trabecular cells formed multicellular spheroids during the first day, Apoptosis occurred selectively and continuously in the spheroids, which had initially been filled with cells, After one month, the final structure of the spheroids had become a meshwork of cells separated by large extracellular spaces, Epidermal and basic fibroblast growth factors prevented apoptosis of the trabecular cells in the spheroids which remained filled with cells for the entire observation period, The trabecular multicellular spheroids may represent the in vitro process of trabecular meshwork formation and can be used as a system for identifying regulatory factors involved in this process.

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  • BOVINE AND PORCINE TRABECULAR CELLS PRODUCE PROSTAGLANDIN F2α IN RESPONSE TO CYCLIC MECHANICAL STRETCHING

    Japanese Journal of Ophthalmology   40 ( 3 )   289 - 296   1996年

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    記述言語:英語  

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  • Intracellular calcium response to hydraulic pressure in human trabecular cells

    Toshihiko Matsuo, Nobuhiko Matsuo

    British Journal of Ophthalmology   80 ( 6 )   561 - 566   1996年

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    記述言語:英語   出版者・発行元:BMJ Publishing Group  

    Aims - To understand the mechanism for regulation of intraocular pressure, human trabecular cells were examined to determine whether they could respond to the change in hydraulic pressure. Methods - Human trabecular cells were cultured from trabeculum tissue fragments excised during trabeculectomy in four eyes of three patients with primary open angle glaucoma and exposed to the change of hydraulic pressure in a tissue culture flask connected to a glass syringe. The pressure was exerted by automatic infusion of the piston of the syringe and monitored by a pressure gauge. The intracellular calcium concentration was measured in real time with a calcium binding fluorescent dye, fluo-3. Results - A small number (about 10%) of cells appearing morphologically to be trabecular cells showed transient elevations or oscillations of the intracellular calcium concentration in response to the elevation of hydraulic pressure to 20-30 mm Hg, indicating that a part of the human trabecular cells could sense the change in hydraulic pressure. Conclusion - Some cells in the human trabecular tissue seem to sense the change in intraocular pressure and might play a role in its regulation.

    DOI: 10.1136/bjo.80.6.561

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  • Inflammation after cataract extraction and intraocular lens implantation in patients with rheumatoid arthritis

    T. Matsuo, M. Fujiwara, N. Matsuo

    British Journal of Ophthalmology   79 ( 6 )   549 - 553   1995年

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    Aims - The purpose of this study was to examine whether preoperative activity of rheumatoid arthritis influences the extent of anterior chamber inflammation after cataract extraction and intraocular lens implantation. Methods - The medical records of 23 consecutive patients (33 eyes) with rheumatoid arthritis, who underwent cataract extraction with intraocular lens implantation, were reviewed during a 4 year period from April 1990 to March 1994. Results - Eleven patients who still showed a 1+ level of aqueous cells 1 month after the surgery had significantly higher titres of rheumatoid factor preoperatively, compared with the other 12 patients who showed no aqueous cells (p = 0.0019, Mann-Whitney U test). The persistence of aqueous cells also had a significant correlation with extracapsular cataract extraction compared with phacoemulsification (p = 0.0391, χ2 test). Multivariate analysis showed that the titre of rheumatoid factor was the more significant element to determine the persistent aqueous inflammation. All the eyes, except for four which had a macular hole, optic disc atrophy, or retinitis pigmentosa gained visual acuity of 20/30 or better. The aqueous cells cleared 3 months after the surgery and left no complications in any of the eyes. Conclusion - Intraocular lens implantation is basically a safe procedure for patients with rheumatoid arthritis, although postoperative aqueous inflammation tends to be persistent in patients with high titres of rheumatoid factor.

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  • INTRAOPERATIVE OBSERVATION OF THE VITREOUS BASE IN PATIENTS WITH ATOPIC-DERMATITIS AND RETINAL-DETACHMENT

    T MATSUO, F SHIRAGA, N MATSUO

    RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES   15 ( 4 )   286 - 290   1995年

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    記述言語:英語   出版者・発行元:LIPPINCOTT-RAVEN PUBL  

    Purpose: Patients with atopic dermatitis often develop tears around the vitreous base. An attempt was made to determine whether these patients had any abnormalities of the vitreous base that would lead to formation of such tears.
    Methods: The medical records and intraoperative videotape recordings of 12 patients with atopic dermatitis and retinal detachment who underwent vitrectomy were reviewed.
    Results: Tears were located at the ora serrata or in the nonpigmented epithelium of the pars plana or plicata of the ciliary body. The vitreous gel at its base was condensed like fluffy cotton in all of the patients, whereas the retina and the continuing nonpigmented epithelium around the ora serrata were wrinkled by contraction of the overlying abnormal gel.
    Conclusion: Frequent occurrence of oral dialyses and tears of the nonpigmented epithelium of the ciliary body in patients with atopic dermatitis could be attributed to the abnormal vitreous gel at its base.

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  • Intraoperative observation of the vitreous base in patients with atopic dermatitis and retinal detachment

    Toshihiko Matsuo, Fumio Shiraga, Nobuhiko Matsuo

    Retina   15 ( 4 )   286 - 290   1995年

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    記述言語:英語  

    Purpose: Patients with atopic dermatitis often develop tears around the vitreous base. An attempt was made to determine whether these patients had any abnormalities of the vitreous base that would lead to formation of such tears. Methods: The medical records and intraoperative videotape recordings of 12 patients with atopic dermatitis and retinal detachment who underwent vitrectomy were reviewed. Results: Tears were located at the ora serrata or in the nonpigmented epithelium of the pars plana or plicata of the ciliary body. The vitreous gel at its base was condensed like fluffy cotton in all of the patients, whereas the retina and the continuing nonpigmented epithelium around the ora serrata were wrinkled by contraction of the overlying abnormal gel. Conclusion: Frequent occurrence of oral dialyses and tears of the nonpigmented epithelium of the ciliary body in patients with atopic dermatitis could be attributed to the abnormal vitreous gel at its base. © The Ophthalmic Communications Society, Inc.

    DOI: 10.1097/00006982-199515040-00003

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  • Photoreceptor outer segments in aqueous humor: Key to understanding a new syndrome

    Toshihiko Matsuo

    Survey of Ophthalmology   39 ( 3 )   211 - 233   1994年

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    記述言語:英語   掲載種別:書評論文,書評,文献紹介等  

    Retinal detachment with oral dialyses and tears of the nonpigmented epithelium of the ciliary body sometimes accompanies aqueous cells and high intraocular pressure with its marked fluctuation. The aqueous cells consist predominantly of photoreceptor outer segments which obstruct aqueous outflow at the trabecular meshwork and induce high intraocular pressure as ghost cells do in ghost cell glaucoma. A new clinical entity with the combination of these signs, namely, rhegmatogenous retinal detachment with "photoreceptor outer segment glaucoma" is designated as Schwartz-Matsuo syndrome in this report. The detection of photoreceptor outer segments in the anterior chamber indicates that a communication between subretinal space and aqueous humor has been established by some mechanism. The new syndrome should be included in differential diagnoses of iritis and glaucoma. © 1994.

    DOI: 10.1016/0039-6257(94)90195-3

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  • Correspondence

    Toshihiko Matsuo

    Retina   14 ( 2 )   192   1994年

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)  

    DOI: 10.1097/00006982-199414020-00021

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  • A mutation in the Pax-6 gene in rat small eye is associated with impaired migration of midbrain crest cells

    T. Matsuo, N. Osumi-Yamashita, S. Noji, H. Ohuchi, E. Koyama, F. Myokai, N. Matsuo, S. Taniguchi, H. Doi, S. Iseki, Y. Ninomiya, M. Fujiwara, T. Watanabe, K. Eto

    Nature Genetics   3 ( 4 )   299 - 304   1993年

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    The rat small eye strain (rSey) lacks eyes and nose in the homozygote, and is similar to the mouse Sey strain with mutations in the Pax-6 gene. We isolated Pax-6 cDNA clones from an rSey homozygote library, and found an internal deletion of about 600 basepairs in the serine/threonine-rich domain. At the genomic level, a single base (G) insertion in an exon generates an abnormal 5′ donor splice site, thereby producing the truncated mRNA. Anterior midbrain crest cells in the homozygous rSey embryos reached the eye rudiments but did not migrate any further to the nasal rudiments, suggesting that the Pax-6 gene is involved in conducting migration of neural crest cells from the anterior midbrain. © 1993 Nature Publishing Group.

    DOI: 10.1038/ng0493-299

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  • Photoreceptor outer segments in the aqueous humor of patients with atopic dermatitis and retinal detachment

    N. Matsuo, T. Matsuo, F. Shiraga, A. Hosoda, Y. Kawanishi, S. Watanabe, H. Ohtsuki

    American Journal of Ophthalmology   115 ( 1 )   21 - 25   1993年

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    We examined the aqueous humor by electron microscopy of four patients with atopic dermatitis and retinal detachment. All the patients had a moderate number of cells in the aqueous humor. Cataract impaired fundus visualization except for one patient with aphakia. A flat retinal detachment involved a wide area detected by echography. The intraocular pressure in the eyes with retinal detachment demonstrated a marked diurnal fluctuation compared with that of the fellow eye. The aqueous cells consisted predominantly of photoreceptor outer segments. This finding does not support the theory that aqueous cells in atopic dermatitis are of inflammatory origin. Photoreceptor outer segments in aqueous humor are indicative of rhegmatogenous retinal detachment in patients with atopic dermatitis.

    DOI: 10.1016/S0002-9394(14)73519-6

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  • Photoreceptor outer segments in the aqueous humor of patients with atopic dermatitis and retinal detachment

    N. Matsuo, T. Matsuo, F. Shiraga, A. Hosoda, Y. Kawanishi, S. Watanabe, H. Ohtsuki

    American Journal of Ophthalmology   115 ( 1 )   21 - 25   1993年

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    We examined the aqueous humor by electron microscopy of four patients with atopic dermatitis and retinal detachment. All the patients had a moderate number of cells in the aqueous humor. Cataract impaired fundus visualization except for one patient with aphakia. A flat retinal detachment involved a wide area detected by echography. The intraocular pressure in the eyes with retinal detachment demonstrated a marked diurnal fluctuation compared with that of the fellow eye. The aqueous cells consisted predominantly of photoreceptor outer segments. This finding does not support the theory that aqueous cells in atopic dermatitis are of inflammatory origin. Photoreceptor outer segments in aqueous humor are indicative of rhegmatogenous retinal detachment in patients with atopic dermatitis.

    DOI: 10.1016/S0002-9394(14)73519-6

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  • HLA-DR9 ASSOCIATED WITH THE SEVERITY OF ACUTE RETINAL NECROSIS SYNDROME

    T MATSUO, N MATSUO

    OPHTHALMOLOGICA   203 ( 3 )   133 - 137   1991年

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    記述言語:英語   出版者・発行元:KARGER  

    We divided 22 patients with acute retinal necrosis syndrome into two groups depending on whether they had its mild (10 patients) or fulminant type (12 patients) and analyzed human leukocyte antigens, HLA-A, -B, -C and -DR loci, to elucidate immunogenetic differences between these two groups. The frequency of HLA-DR9 was found to be high in patients with the fulminant type (50.0%) compared with that in the patients with the mild type (0.0%), which was significant (p < 0.05) in a chi-2 test with Yates' correction but did not remain significant when the probability was corrected by the number of antigens tested. The result suggests that immunogenetic predisposition plays a role in aggravation of acute retinal necrosis syndrome.

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  • RETINAL-PIGMENT EPITHELIAL TEAR IN REACTIVE LYMPHOID HYPERPLASIA OF UVEA

    T MATSUO, N MATSUO, F SHIRAGA, K TAKEUCHI

    OPHTHALMOLOGICA   200 ( 1 )   46 - &   1990年

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  • RETINAL VASCULITIS AS A COMPLICATION OF RHEUMATOID-ARTHRITIS

    T MATSUO, T KOYAMA, N MORIMOTO, H UMEZU, N MATSUO

    OPHTHALMOLOGICA   201 ( 4 )   196 - 200   1990年

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  • NO MAJOR DEFECT DETECTED IN THE GENE OF FAMILIAL HYPO-RETINOL-BINDING PROTEINEMIA

    T MATSUO, S NOJI, S TANIGUCHI, N MATSUO

    JAPANESE JOURNAL OF OPHTHALMOLOGY   34 ( 3 )   320 - 324   1990年

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    記述言語:英語   出版者・発行元:JAPAN J OPHTHALMOL  

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  • NO MAJOR DEFECT DETECTED IN THE GENE OF FAMILIAL HYPO-RETINOL-BINDING PROTEINEMIA

    T MATSUO, S NOJI, S TANIGUCHI, N MATSUO

    JAPANESE JOURNAL OF OPHTHALMOLOGY   34 ( 3 )   320 - 324   1990年

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  • Retinal pigment epithelial tear in reactive lymphoid hyperplasia of uvea

    Toshihiko Matsuo, Nobuhiko Matsuo, Fumio Shiraga, Kyoko Takeuchi

    Ophthalmologica   200 ( 1 )   46 - 54   1990年

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    記述言語:英語  

    A 76-year-old patient developed cystic exudative retinal detachment with many yellowish subretinal precipitates and a large retinal pigment epithelial (RPE) tear in midperiphery of the right eye in the course of polyclonal hypergammaglobulinemia. The left eye showed localized RPE detachment in the posterior pole which gradually extended. Systemic steroid administration reduced the subretinal precipitates to some extent, but suspicion of malignancy led to enucleation of the right eye after unsuccessful diagnostic vitrectomy. A histopathological study revealed massive infiltration of the uvea with plasma cells and small lymphocytes but no abnormal cells. This is the first report to show the association of an RPE tear with reactive lymphoid hyperplasia of the uvea. © 1990 S. Karger AG, Basel.

    DOI: 10.1159/000310076

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  • Acute retinal necrosis as a novel complication of chickenpox in adults

    T. Matsuo, M. Koyama, N. Matsuo

    British Journal of Ophthalmology   74 ( 7 )   443 - 444   1990年

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    記述言語:英語   出版者・発行元:BMJ Publishing Group  

    Three patients in their 20s suffered from chickenpox while in an immunocompromised state: one in pregnancy, one during a long course of corticosteroid for severe nephrotic syndrome, and the third with repeated upper airway infection due to bronchiectasis. They developed acute retinal necrosis about three weeks after the onset of chickenpox. Since acute retinal necrosis threatens sight, this unusual complication of chickenpox in adults needs serious consideration.

    DOI: 10.1136/bjo.74.7.443

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  • RETINAL VASCULITIS AS A COMPLICATION OF RHEUMATOID-ARTHRITIS

    T MATSUO, T KOYAMA, N MORIMOTO, H UMEZU, N MATSUO

    OPHTHALMOLOGICA   201 ( 4 )   196 - 200   1990年

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  • Unusual exudative retinal detachment 9 months after scleral buckling surgery

    Toshihiko Matsuo, Koji Eguchi, Nobuhiko Matsuo

    Ophthalmologica   201 ( 2 )   79 - 82   1990年

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    記述言語:英語  

    A 49-year-old man developed exudative retinal detachment 9 months after uncomplicated scleral buckling surgery in the left eye. The subretinal exudates were strictly localized along the buckle and showed remarkable response to steroid. The cause would be nonin- fectious inflammation like posterior scleritis, triggered by the buckle itself or its associated factors. It is important to note that subretinal exudates long after scleral buckling can occur in consequence of steroid-responsive inflammation as well as insidious bacterial or fungal infection described previously. © 1990 S. Karger AG, Basel.

    DOI: 10.1159/000310131

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  • KERATOMALACIA IN A CHILD WITH FAMILIAL HYPO-RETINOL-BINDING PROTEINEMIA

    T MATSUO, N MATSUO, F SHIRAGA, N KOIDE

    JAPANESE JOURNAL OF OPHTHALMOLOGY   32 ( 3 )   249 - 254   1988年

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    記述言語:英語   出版者・発行元:JAPAN J OPHTHALMOL  

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  • CHARACTERIZATION OF RETINOL-BINDING PROTEIN IN FAMILIAL HYPO-RETINOL-BINDING PROTEINEMIA

    T MATSUO, N MATSUO

    JAPANESE JOURNAL OF OPHTHALMOLOGY   32 ( 4 )   379 - 384   1988年

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    記述言語:英語   出版者・発行元:JAPAN J OPHTHALMOL  

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  • ACUTE RETINAL NECROSIS SYNDROME FOLLOWING CHICKENPOX IN PREGNANT WOMAN

    T MATSUO, A OHNO, N MATSUO

    JAPANESE JOURNAL OF OPHTHALMOLOGY   32 ( 1 )   70 - 74   1988年

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    記述言語:英語   出版者・発行元:JAPAN J OPHTHALMOL  

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  • KERATOMALACIA IN A CHILD WITH FAMILIAL HYPO-RETINOL-BINDING PROTEINEMIA

    T MATSUO, N MATSUO, F SHIRAGA, N KOIDE

    JAPANESE JOURNAL OF OPHTHALMOLOGY   32 ( 3 )   249 - 254   1988年

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    記述言語:英語   出版者・発行元:JAPAN J OPHTHALMOL  

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  • ACUTE RETINAL NECROSIS SYNDROME FOLLOWING CHICKENPOX IN PREGNANT WOMAN

    T MATSUO, A OHNO, N MATSUO

    JAPANESE JOURNAL OF OPHTHALMOLOGY   32 ( 1 )   70 - 74   1988年

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  • CYTOLOGICAL AND IMMUNOLOGICAL STUDY OF THE AQUEOUS-HUMOR IN ACUTE RETINAL NECROSIS SYNDROME

    T MATSUO, T NAKAYAMA, T KOYAMA, N MATSUO

    OPHTHALMOLOGICA   195 ( 1 )   38 - 44   1987年

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  • CYTOLOGICAL AND IMMUNOLOGICAL STUDY OF THE AQUEOUS-HUMOR IN ACUTE RETINAL NECROSIS SYNDROME

    T MATSUO, T NAKAYAMA, T KOYAMA, N MATSUO

    OPHTHALMOLOGICA   195 ( 1 )   38 - 44   1987年

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  • IMMUNOLOGICAL STUDIES OF UVEITIS .2. IMMUNE-COMPLEX CONTAINING RETINAL-S-ANTIGEN IN PATIENT WITH CHRONIC INTRACTABLE UVEITIS

    T MATSUO, T NAKAYAMA, T TSUJI, T KOYAMA, N MATSUO, N KOIDE

    JAPANESE JOURNAL OF OPHTHALMOLOGY   30 ( 4 )   480 - 486   1986年

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    記述言語:英語   出版者・発行元:JAPAN J OPHTHALMOL  

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  • IMMUNOLOGICAL STUDIES OF UVEITIS .2. IMMUNE-COMPLEX CONTAINING RETINAL-S-ANTIGEN IN PATIENT WITH CHRONIC INTRACTABLE UVEITIS

    T MATSUO, T NAKAYAMA, T TSUJI, T KOYAMA, N MATSUO, N KOIDE

    JAPANESE JOURNAL OF OPHTHALMOLOGY   30 ( 4 )   480 - 486   1986年

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    記述言語:英語   出版者・発行元:JAPAN J OPHTHALMOL  

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  • IMMUNOLOGICAL STUDIES OF UVEITIS .1. IMMUNE-COMPLEX CONTAINING HERPESVIRUS ANTIGENS IN 4 PATIENTS WITH ACUTE RETINAL NECROSIS SYNDROME

    T MATSUO, T NAKAYAMA, N MATSUO, N KOIDE

    JAPANESE JOURNAL OF OPHTHALMOLOGY   30 ( 4 )   472 - 479   1986年

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    記述言語:英語   出版者・発行元:JAPAN J OPHTHALMOL  

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  • IMMUNOLOGICAL STUDIES OF UVEITIS .1. IMMUNE-COMPLEX CONTAINING HERPESVIRUS ANTIGENS IN 4 PATIENTS WITH ACUTE RETINAL NECROSIS SYNDROME

    T MATSUO, T NAKAYAMA, N MATSUO, N KOIDE

    JAPANESE JOURNAL OF OPHTHALMOLOGY   30 ( 4 )   472 - 479   1986年

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    記述言語:英語   出版者・発行元:JAPAN J OPHTHALMOL  

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  • IMMUNOLOGICAL STUDIES OF UVEITIS .3. CELL-MEDIATED-IMMUNITY TO INTERPHOTO-RECEPTOR RETINOID-BINDING PROTEIN

    T MATSUO, T NAKAYAMA, T KOYAMA, M KOYAMA, S FUJIMOTO, N MATSUO

    JAPANESE JOURNAL OF OPHTHALMOLOGY   30 ( 4 )   487 - 494   1986年

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    記述言語:英語   出版者・発行元:JAPAN J OPHTHALMOL  

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  • IMMUNOLOGICAL STUDIES OF UVEITIS .3. CELL-MEDIATED-IMMUNITY TO INTERPHOTO-RECEPTOR RETINOID-BINDING PROTEIN

    T MATSUO, T NAKAYAMA, T KOYAMA, M KOYAMA, S FUJIMOTO, N MATSUO

    JAPANESE JOURNAL OF OPHTHALMOLOGY   30 ( 4 )   487 - 494   1986年

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    記述言語:英語   出版者・発行元:JAPAN J OPHTHALMOL  

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▼全件表示

講演・口頭発表等

  • 第75回日本臨床眼科学会「眼表面の巨大な悪性黒色腫に対する陽子線治療」

    松尾俊彦, 山崎修, 田中 健大, 勝井邦彰, 脇隆博

    第75回日本臨床眼科学会  2021年10月28日 

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    開催年月日: 2021年10月28日 - 2021年10月31日

    会議種別:ポスター発表  

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  • 第77回日本弱視斜視学会総会「内斜視と外斜視の遺伝的背景の違い」

    松尾俊彦, 張青々, 濱崎一郎, 佐藤和広

    第77回日本弱視斜視学会総会  2021年7月2日 

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    開催年月日: 2021年7月2日 - 2021年7月3日

    会議種別:口頭発表(一般)  

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  • 第61回日本リンパ網内系学会総会「両側涙腺IgG4関連疾患の18年後に発症した全身のびまん性大細胞B細胞リンパ腫」

    松尾俊彦, 田中健大, 岡田和也, 能登原憲司

    第61回日本リンパ網内系学会総会  2021年6月25日 

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    開催年月日: 2021年6月24日 - 2021年6月27日

    会議種別:口頭発表(一般)  

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  • 第125回日本眼科学会総会「Pooled DNAの全エクソーム解析による内斜視と外斜視の量的形質遺伝子座解析」

    松尾俊彦, 張青々, 濱崎一郎, 佐藤和広

    第125回日本眼科学会総会  2021年4月9日 

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    開催年月日: 2021年4月8日 - 2021年4月11日

    会議種別:口頭発表(一般)  

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  • 第58回日本人工臓器学会大会「光電変換色素結合薄膜型人工網膜(OUReP)の治験に向けたマウス変性網膜の神経スパイク誘発試験と人工網膜注入器の開発」

    松尾俊彦, 内田哲也

    第58回日本人工臓器学会大会  2020年11月13日 

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    開催年月日: 2020年11月12日 - 2020年11月14日

    会議種別:口頭発表(一般)  

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  • 2020年度繊維学会秋季研究発表会「光電変換色素を用いた高分子薄膜型人工網膜の長期耐久性の向上」

    山下功一郎, 田中天羽, 内田哲也, 松尾俊彦

    2020年度繊維学会秋季研究発表会  2020年11月5日 

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    開催年月日: 2020年11月5日 - 2020年11月6日

    会議種別:口頭発表(一般)  

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  • 第74回日本臨床眼科学会「涙腺腫脹を契機に診断したIgG4関連疾患の血清IgG4値による経過観察」

    松尾俊彦, 田中 健大, 佐藤 康晴, 片岡 仁美, 宇賀 麻由, 遠西 大輔, 矢野 朋文

    第74回日本臨床眼科学会  2020年10月16日 

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    開催年月日: 2020年10月15日 - 2020年10月18日

    会議種別:口頭発表(一般)  

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  • 第45回日本小児眼科学会総会「若年性特発性関節炎の難治性ぶどう膜炎に対してヒュミラを導入し5年経過観察した1例」

    松尾俊彦, 八代将登

    第76回日本弱視斜視学会総会・第45回日本商機眼科学会総会合同学会  2020年6月26日 

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    開催年月日: 2020年6月26日 - 2020年6月27日

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  • 第60回日本リンパ網内系学会総会「涙腺腫脹でIgG4関連疾患と診断された6例の血清IgG4値による長期経過観察」

    松尾俊彦, 田中健大, 佐藤康晴, 片岡仁美, 宇賀麻由, 遠西大輔, 矢野朋文

    第60回日本リンパ網内系学会総会  2020年5月28日 

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    開催年月日: 2020年5月29日 - 2020年5月30日

    会議種別:ポスター発表  

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  • 第59回日本生体医工学会大会「光電変換色素結合薄膜型人工網膜によって誘起されるrd1マウス摘出変性網膜組織の活動電位スパイク」

    松尾俊彦, 内田哲也

    第59回日本生体医工学会大会  2020年5月26日 

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    開催年月日: 2020年5月25日 - 2020年5月27日

    会議種別:口頭発表(一般)  

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  • 2020 ARVO Annual Meeting "A new knock-out mouse model (MGST2 gene knock-out) of strabismus."

    Chaomulige, Toshihiko Matsuo, Shihui Liu, Mary Miyaji, Osamu Hosoya, Izuho Hatada, Takuro Horii

    2020 Annual Meeting of Association for Research in Vision and Ophthalmology (ARVO)  2020年5月5日 

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    開催年月日: 2020年5月3日 - 2020年5月7日

    会議種別:ポスター発表  

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  • 2020 ARVO Annual Meeting "Prevent photoreceptor cells from apoptosis by a cryptocyanine drug (Nk-4), in RCS rats."

    Shihui Liu, Toshihiko Matsuo, Mary Miyaji, Osamu Hosoya

    2020 Annual Meeting of Association for Research in Vision and Ophthalmology (ARVO)  2020年5月4日 

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    開催年月日: 2020年5月3日 - 2020年5月7日

    会議種別:ポスター発表  

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  • 第124回日本眼科学会総会「21世紀出生時縦断調査における幼少時のテレビ視聴と学童期の視力低下の関連」

    松尾俊彦, 頼藤貴志

    第124回日本眼科学会総会  2020年4月17日 

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    開催年月日: 2020年4月16日 - 2020年4月19日

    会議種別:口頭発表(一般)  

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  • (2019年度難治性疾患実用化研究事業・免疫アレルギー疾患実用化研究事業合同成果報告会「岡山大学方式人工網膜(OUReP)の製造品質管理とfirst-in-human医師主導治験」

    松尾俊彦, 内田哲也, 櫻井淳, 蔵本孝一, 細谷修, 正岡英治, 劉詩卉

    (2019年度難治性疾患実用化研究事業・免疫アレルギー疾患実用化研究事業合同成果報告会)日本医療研究開発機構  2020年2月7日 

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    開催年月日: 2020年2月7日 - 2020年2月8日

    会議種別:ポスター発表  

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  • 第12回Retina Research Meeting「光電変換色素結合薄膜型人工網膜OURePによって誘起されるrd1マウス摘出変性網膜組織の活動電位スパイクの検出」

    松尾俊彦

    第12回Retina Research Meeting  2019年11月30日 

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    開催年月日: 2019年11月30日 - 2019年12月30日

    会議種別:口頭発表(一般)  

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  • 第41回日本バイオマテリアル学会「光電変換色素固定高分子薄膜型人工網膜から生じる電気刺激るが網膜細胞へ与える影響の解明」

    山下功一郎, 田中天羽, 内田哲也, 松尾俊彦, Willy Wong

    第41回日本バイオマテリアル学会  2019年11月24日 

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    開催年月日: 2019年11月24日 - 2019年11月26日

    会議種別:口頭発表(一般)  

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  • The 8th Meeting of the International Federation for Artificial Organs (IFAO2019) IFAO-APSAO Joint Symposium "Photoelectric dye-coupled polyethylene film: photoreseponsive properties evaluated by Kelvin probe and in vitro biological response detected in dystrophc retinal tissue"

    Toshihiko Matsuo, Tetsuya Uchida

    The 8th Meeting of the International Federation for Artificial Organs (IFAO2019)  2019年11月14日 

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    開催年月日: 2019年11月13日 - 2019年11月15日

    会議種別:シンポジウム・ワークショップ パネル(公募)  

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  • 第27回プラスチック成形加工学会秋季大会「高分子結晶で被覆したナノセルロースのスケールアップ作製~作製条件と構造および分散性の関係~」

    藪根亮太, 松尾俊彦, 内田哲也

    第27回プラスチック成形加工学会秋季大会  2019年11月13日 

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    開催年月日: 2019年11月12日 - 2019年11月13日

    会議種別:口頭発表(一般)  

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  • 第27回プラスチック成形加工学会秋季大会「ポリエチレンを基板とした光電変換色素固定薄膜型人工網膜のアニオン交換と耐久性向上評価」

    田中天羽, 山下功一郎, 内田哲也, 松尾俊彦

    第27回プラスチック成形加工学会秋季大会  2019年11月12日 

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    開催年月日: 2019年11月12日 - 2019年11月13日

    会議種別:口頭発表(一般)  

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  • 2019年度繊維学会秋季研究発表会「光電変換色素固定高分子薄膜型人工網膜と双極細胞間における神経伝達機構の原理解明」

    山下功一郎, 田中天羽, 内田哲也, 松尾俊彦, Willy Wong

    2019年度繊維学会秋季研究発表会  2019年11月9日 

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    開催年月日: 2019年11月9日 - 2019年11月10日

    会議種別:口頭発表(一般)  

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  • 2019年度繊維学会秋季研究発表会「光電変換色素固定高分子薄膜型人工網膜の構造と物性評価」

    田中天羽, 山下功一郎, 内田哲也, 松尾俊彦

    2019年度繊維学会秋季研究発表会  2019年11月9日 

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    開催年月日: 2019年11月9日 - 2019年11月10日

    会議種別:口頭発表(一般)  

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  • 2019年度繊維学会秋季研究発表会「高分子結晶で被覆したセルロースナノファイバーの作製~作製条件と構造および分散性の関係~」

    藪根亮太, 松尾俊彦, 内田哲也

    2019年度繊維学会秋季研究発表会  2019年11月9日 

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    開催年月日: 2019年11月9日 - 2019年11月10日

    会議種別:口頭発表(一般)  

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  • 第34回中国四国地区高分子若手研究会「ポリエチレンを基板とした光電変換色素固定薄膜型人工網膜のアニオン交換と耐久性向上評価」

    田中天羽, 山下功一郎, 内田哲也, 松尾俊彦

    第34回中国四国地区高分子若手研究会  2019年10月31日 

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    開催年月日: 2019年10月31日 - 2019年11月1日

    会議種別:口頭発表(一般)  

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  • 第34回中国四国地区高分子若手研究会「高分子結晶で被覆したナノセルロースのスケールアップ作製と作製条件による構造および分散性の関係」

    藪根亮太, 松尾俊彦, 内田哲也

    第34回中国四国地区高分子若手研究会  2019年10月31日 

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    開催年月日: 2019年10月31日 - 2019年11月1日

    会議種別:口頭発表(一般)  

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  • 第73回日本臨床眼科学会「先天眼瞼下垂における不同視の発生時期」

    松尾俊彦

    第73回日本臨床眼科学会  2019年10月24日 

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    開催年月日: 2019年10月24日 - 2019年10月27日

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  • 材料学会 第5回材料WEEK「高分子結晶で被覆したナノセルロースのスケールアップ作製~作製条件が構造および分散性に及ぼす影響~」

    藪根亮太, 松尾俊彦, 内田哲也

    材料学会 第5回材料WEEK  2019年10月15日 

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    開催年月日: 2019年10月15日 - 2019年10月18日

    会議種別:口頭発表(一般)  

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  • 第68回高分子討論会「高分子結晶で被覆したセルロースナノファイバーの作製~作製条件による構造と分散性の関係~」

    藪根亮太, 松尾俊彦, 内田哲也

    第68回高分子討論会  2019年9月26日 

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    開催年月日: 2019年9月25日 - 2019年9月27日

    会議種別:口頭発表(一般)  

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  • 第68回高分子討論会「光電変換色素固定高分子薄膜型人工網膜から生じる電気刺激と網膜細胞間における神経伝達機構の原理解明」

    山下功一郎, 田中天羽, 内田哲也, 松尾俊彦, Willy Wong

    第68回高分子討論会  2019年9月26日 

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    開催年月日: 2019年9月25日 - 2019年9月27日

    会議種別:口頭発表(一般)  

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  • セルロース学会第26回年次大会「高分子結晶で被覆したTEMPO酸化セルロースナノファイバーの分散性と吸着特性」

    藪根亮太, 松尾俊彦, 北村武大, 森田祐子, 内田哲也

    セルロース学会第26回年次大会  2019年7月11日 

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    開催年月日: 2019年7月11日 - 2019年7月12日

    会議種別:口頭発表(一般)  

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  • 第59回日本リンパ網内系学会総会「中枢神経系リンパ腫を発症しない眼内リンパ腫はあるか?」

    松尾俊彦, 田中健大

    第59回日本リンパ網内系学会総会  2019年6月28日 

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    開催年月日: 2019年6月29日

    会議種別:ポスター発表  

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  • 第75回日本弱視斜視学会総会「三桿法、静的立体視検査での基底外方、上方プリズム装用の影響」

    松尾俊彦, 細木良祐

    第75回日本弱視斜視学会総会  2019年6月14日 

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    開催年月日: 2019年6月14日 - 2019年6月15日

    会議種別:口頭発表(一般)  

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  • 第123回日本眼科学会総会「岡山大学方式人工網膜(OUReP)によるラット/マウス変性網膜の活動電位スパイク誘発」

    松尾俊彦, 寺田慧子, 櫻井省花子, 内田哲也

    第123回日本眼科学会総会  2019年4月19日 

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    開催年月日: 2019年4月18日 - 2019年4月21日

    会議種別:ポスター発表  

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  • The Future for Japanese Science: Vision towards achieving the sustainable development goals. Nature 150 Anniversary Symposium’s poster session. Photoelectric dye-coupled thin film as retinal prosthesis for the blind to gain the sight again.

    Toshihiko Matsuo, Tetsuya Uchida

    The Future for Japanese Science: Vision towards achieving the sustainable development goals. Nature 150 Anniversary Symposium’s poster session.  2019年4月4日 

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    開催年月日: 2019年4月4日

    会議種別:ポスター発表  

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  • 疾患克服の挑戦2018(2018年度6事業合同成果報告会)「岡山大学方式人工網膜(OUReP)の製造品質管理とfirst-in-human医師主導治験」

    松尾俊彦, 内田哲也, 櫻井淳, 蔵本孝一, 細谷修, 正岡英治, 劉詩卉

    疾患克服の挑戦2018(2018年度6事業合同成果報告会)日本医療研究開発機構  2019年2月7日 

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    開催年月日: 2019年2月7日 - 2019年2月8日

    会議種別:口頭発表(招待・特別)  

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  • 光電変換色素薄膜型人工網膜 神経伝導メカニズム解明 岡山大と加トロント大が共同

    内田哲也, 山下功一郎, 松尾俊彦

    科学新聞 第3837号  2021年8月6日 

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  • 第74回日本弱視斜視学会総会「三桿法と実用視力との相関」

    第73回日本弱視斜視学会総会  2018年 

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  • 第72回日本臨床眼科学会「上方結膜温存・耳側切開創からの水平方向対面通糸法による眼内レンズ縫着」

    第72回日本臨床眼科学会  2018年 

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  • 第56回日本人工臓器学会大会パネルディスカッション人工臓器開発における非臨床試験「岡山大学方式人工網膜(OUReP)によるラット変性網膜の網膜電図誘発」

    第56回日本人工臓器学会大会  2018年 

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  • 平成29年度「橋渡し研究戦略的プログラム」成果活用支援事業「網膜疾患」光電変換色素結合薄膜型人工網膜(OUReP)による網膜色素変性視覚喪失の改善法

    疾患克服戦略会議―網膜色素変性症ー 「光電変換色素結合薄膜型人工網膜(OUReP)による網膜色素変性視覚喪失の改善法」  2018年 

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  • 第122回日本眼科学会総会「黄斑変性サル眼への岡山大学方式人工網膜(OUReP)植込みと視覚誘発電位の回復」

    第122回日本眼科学会総会  2018年 

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  • 2018 ARVO Annual Meeting "Key pathways and genes influenced by a drug, NK-4(Lumin), in human neurons and Royal College Surgeon Rats."

    2018 Annual Meeting of Association for Research in Vision and Ophthalmology (ARVO)  2018年 

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  • 2018年度繊維学会年次大会「光電変換色素固定ポリエチレン薄膜型人工網膜表面に結合した色素の均一性および安定性評価

    2018年度繊維学会年次大会  2018年 

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  • 第57回日本リンパ網内系学会総会「乳腺リンパ腫(DLBCL)治療後に眼内リンパ腫として再発した1例」

    第58回日本リンパ網内系学会総会  2018年 

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  • 平成29年度岡山大学研究シーズ発信会「光電変換色素NK-5962(林原)の視細胞保護効果~変性疾患での内服・サプリメントを目指して」

    平成29年度 岡山大学研究シーズ発信会  2017年 

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  • 日本医療研究開発機構 革新的医療技術創出拠点プロジェクト 平成28年度成果報告会【シーズ発表・医療機器】岡山大学方式の人工網膜の医師主導治験の準備と実施:生物学的安全性評価・製造・品質管理・第I相・II相試験

    日本医療研究開発機構 革新的医療技術創出拠点プロジェクト 平成28年度成果報告会「岡山大学方式の人工網膜の医師主導治験の準備と実施:生物学的安全性評価・製造・品質管理・第I相・II相試験」  2017年 

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  • 第121回日本眼科学会総会「共同性斜視関連遺伝子座の家系内SNP解析による遺伝子の絞り込み」

    第121回日本眼科学会総会  2017年 

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  • 2017 ARVO Annual Meeting "NK-4 dye reduces the apoptosis of photoreceptor cells."

    2017 Annual Meeting of Association for Research in Vision and Ophthalmology (ARVO)  2017年 

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  • 第73回日本弱視斜視学会総会「遺伝統計学によって辿り着いた共同性斜視に関連する遺伝子」

    第73回日本弱視斜視学会総会  2017年 

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  • 第57回日本リンパ網内系学会総会「眼窩涙腺部腫瘍生検で木村病と確定した後にネフローゼ症候群を発症した1例」

    第57回日本リンパ網内系学会総会  2017年 

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  • CNS 2017 "Retinal prostheses from stimulation to seeing."

    CNS 2017, 26th Annual Computational Neuroscience Meeting  2017年 

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  • 第55回日本人工臓器学会大会「黄斑変性サル眼への岡山大学方式人工網膜(OUReP)植込みと視覚誘発電位の回復」

    第55回日本人工臓器学会大会  2017年 

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  • 第71回日本臨床眼科学会シンポジウム「眼内腫瘍の最新画像診断学」「眼内腫瘍の眼底自発蛍光と広角眼底カメラ」

    第71回日本臨床眼科学会  2017年 

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  • 第62回日本人類遺伝学会大会「連鎖解析と家系内相関解析によって辿り着いた共同性斜視に関連する遺伝子」

    第62回日本人類遺伝学会大会  2017年 

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  • 第10回Retina Research Meeting特別講演 "Non-clinical tests and investigator-initiated clinical trial of photoelectric dye-coupled thin film retinal prosthesis (OUReP)"「光電変換色素結合薄膜型人工網膜(OUReP)の非臨床試験と医師主導治験」

    第10回Retina Research Meeting特別講演 "Non-clinical tests and investigator-initiated clinical trial of photoelectric dye-coupled thin film retinal prosthesis (OUReP)"「光電変換色素結合薄膜型人工網膜(OUReP)の非臨床試験と医師主導治験」  2017年 

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  • 平成29年度岡山大学研究シーズ発信会「光電変換色素NK-5962(林原)の視細胞保護効果~変性疾患での内服・サプリメントを目指して~」

    平成29年度 岡山大学 研究シーズ発信会  2017年 

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  • 第54回日本人工臓器学会大会「硝子体手術によるイヌでの岡山大学方式人工網膜(OUReP)植込みと摘出手術、摘出品の物性評価」

    第54回日本人工臓器学会大会  2016年 

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  • 科学技術振興機構JST岡山大学新技術説明会「網膜神経細胞のアポトーシスを抑制する光電変換色素分子」

    科学技術振興機構JST岡山大学新技術説明会  2016年 

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  • 日本医療研究開発機構AMEDプロジェクト連携シンポジウム(オールジャパンでの医療機器開発)「岡山大学方式の人工網膜の医師主導治験の準備と実施:生物学的安全性評価・製造・品質管理・第I相・II相試験」

    日本医療研究開発機構AMEDプロジェクト連携シンポジウム(オールジャパンでの医療機器開発)「岡山大学方式の人工網膜の医師主導治験の準備と実施:生物学的安全性評価・製造・品質管理・第I相・II相試験」  2016年 

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  • 文部科学省・厚生労働省 革新的医療技術創出拠点プロジェクト 平成27年度成果報告会【シーズ発表・医療機器】岡山大学方式の人工網膜の医師主導治験の準備と実施:生物学的安全性評価・製造・品質管理・第I相・II相試験

    文部科学省・厚生労働省 革新的医療技術創出拠点プロジェクト 平成27年度成果報告会  2016年 

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  • The 13th International Congress of Human Genetics (ICHG2016) "Candidate genes for strabismus (esotropia and exotropia) susceptibility chromosomal loci."

    The 13th International Congress of Human Genetics (ICHG2016) April 3-7, 2016, Kyoto, Japan  2016年 

     詳細を見る

  • 第120回日本眼科学会総会「岡山大学方式人工網膜(OUReP)植込み網膜色素変性(RCS)ラットでの視覚誘発電位の記録」

    第120回日本眼科学会総会  2016年 

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  • 第72回日本弱視斜視学会総会「動的奥行知覚検査としての三稈法測定の再現性(続報)」

    第72回日本弱視斜視学会総会  2016年 

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  • 第56回日本リンパ網内系学会総会「びまん性大細胞B細胞リンパ腫に対する自己末梢血幹細胞移植後の涙腺MALTリンパ腫」

    第56回日本リンパ網内系学会総会  2016年 

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  • 「次世代AIを考える」意見交換会:新方式人工網膜「光電変換色素結合薄膜型」

    「次世代AIを考える」意見交換会  2016年 

     詳細を見る

  • LES 2016 Annual Meeting "Photoelectric dye-coupled thin film as a novel type of retinal prosthesis."

    LES (Licensing Executives Society) (USA and Canada) 2016 Annual Meeting  2016年 

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  • 第70回日本臨床眼科学会シンポジウム12「眼部腫瘍診断の最前線~微量検体からわかること~」「生化学検査」

    第70回日本臨床眼科学会  2016年 

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  • 第3回弘前医療技術イノベーションシンポジウム セッション2「網膜疾患に対する新規デバイスの開発」光電変換色素結合薄膜型(岡山大学方式)人工網膜OURePの医師主導治験

    第3回弘前医療技術イノベーションシンポジウム 6th World Centenarian Initiative「光をもういちどー要介護0社会を目指してー」  2016年 

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  • 第53回日本人工臓器学会大会「岡山大学方式の人工網膜(OUReP)を植込んだ網膜色素変性(RCS)ラットの視覚誘発電位」

    第53回日本人工臓器学会大会  2015年 

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  • 文部科学省・厚生労働省 革新的医療技術創出拠点プロジェクト 平成26年度成果報告会【シーズ発表・医療機器】岡山大学方式の人工網膜の医師主導治験:生物学的安全性評価・製造・品質管理

    文部科学省・厚生労働省 革新的医療技術創出拠点プロジェクト 平成26年度成果報告会「医療イノベーション創出ネットワークの現状と展望~新しいフェーズに入ったアカデミアのシーズ開発」  2015年 

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  • 第119回日本眼科学会総会シンポジウム「神経眼科疾患における遺伝子異常ー新たな発見ー」外眼筋麻痺と原因遺伝子

    第119回日本眼科学会総会  2015年 

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  • 第71回日本弱視斜視学会総会「動的奥行知覚検査としての三稈法測定の再現性」

    第71回日本弱視斜視学会総会  2015年 

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  • 第55回日本リンパ網内系学会総会「網膜黄白色斑と前房蓄膿で再発した節外性NK/T細胞リンパ腫の1例」

    第55回日本リンパ網内系学会総会  2015年 

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  • Bio-Japan 2015 日本医療研究開発機構AMEDブース「岡山大学方式の人工網膜の医師主導治験の準備と実施」

    Bio-Japan 2015 日本医療研究開発機構AMEDブース  2015年 

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  • 第69回日本臨床眼科学会「特発性外眼筋炎7症例の長期経過」

    第69回日本臨床眼科学会  2015年 

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  • 結膜デルモイドの手術例と非手術例の臨床的特徴

    第68回日本臨床眼科学会  2014年 

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  • 上斜筋麻痺の手術回数に影響を与える因子

    第70回日本弱視斜視学会総会  2014年 

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  • AAPOS (American Assoication for Pediatric Ophthalmology and Strabismus) and JAPO 2014 Joint Meeting "Benchmark for clinical decision-making of observation or lensectomy in patients with ectopia lentis."

    AAPOS (American Assoication for Pediatric Ophthalmology and Strabismus), JAPO (Japanese Association for Pediatric Ophthalmology), and JASA (Japanese Association for Strabismus and Ambyopia) 2014 Joint Meeting  2014年 

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  • XIIth ISA (International Strabismological Association) 2014 Meeting "Candidate genes for strabismus susceptibility locus.”

    XIIth ISA (International Strabismological Association) 2014 Meeting  2014年 

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  • 1歳未満児の片眼性先天白内障の第一次硝子体過形成遺残(前部型)合併と眼内レンズ挿入

    第118回日本眼科学会総会  2014年 

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  • Vision recovery and retinal apoptosis reduction in RCS rats with Okayama University-type retinal prosthesis.

    2014 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2014 Annual Meeting)  2014年 

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  • 慢性リンパ性白血病経過中に結膜病変生検でマントル細胞リンパ腫と診断された1例

    第54回日本リンパ網内系学会総会  2014年 

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  • LES 2014 Annual Meeting "Photoelectric dye-coupled thin film as a novel type of retinal prosthesis."

    LES (Licensing Executives Society) (USA and Canada) 2014 Annual Meeting  2014年 

     詳細を見る

  • 網膜色素変性RCSラットでの岡山大学方式人工網膜の長期埋め込み効果

    第52回日本人工臓器学会大会  2014年 

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  • 共同性斜視関連遺伝子座の家計内SNP解析による絞り込み

    日本人類遺伝学会 第58回大会  2013年 

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  • 岡山大学方式人工網膜を埋め込んだRCSラットの行動実験による視覚と網膜神経保護

    第117回日本眼科学会総会  2013年 

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  • 三稈法と静的立体視検査との相関

    第69回日本弱視斜視学会総会  2013年 

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  • 岡山大学方式の人工網膜

    平成25年度 医工連携推進シンポジウム  2013年 

     詳細を見る

  • 岡山大学方式の人工網膜の医師主導治験に向けた生物学的安全性試験の実施

    第35回公益財団法人両備てい園記念財団 助成金贈呈式  2013年 

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  • 小児における先天性水晶体亜脱臼の手術時期

    第67回日本臨床眼科学会  2013年 

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  • 岡山大学方式の人工網膜を埋め込んだRCSラット網膜の変化

    第50回日本人工臓器学会大会  2012年 

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  • 岡山大学方式の人工網膜(光電変換色素結合ポリエチレン・フィルム)の品質

    第116回日本眼科学会総会  2012年 

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  • 複視が重心動揺と重心位置に及ぼす影響の再検証

    第68回日本弱視斜視学会総会  2012年 

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  • 脈絡膜悪性黒色腫のPET/CTによる検出

    第66回日本臨床眼科学会  2012年 

     詳細を見る

  • 網膜色素変性

    岡山県難病相談・支援センター医療講演  2011年 

     詳細を見る

  • 特発性(先天性)上斜筋麻痺の遺伝型と表現型との関係

    第65回 日本臨床眼科学会  2011年 

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  • 結膜MALTリンパ腫のPET/CTでの評価

    戴65回日本臨床眼科学会  2011年 

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  • 特発性(先天性)上斜筋麻痺の遺伝型と表現型との関係

    日本人類遺伝学会 第56回大会  2011年 

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  • 岡山大学方式の人工網膜(光電変換色素結合ポリエチレン・フィルム)の感度改良

    第49回日本人工臓器学会大会  2011年 

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  • 特別講演「眼科医に必要な全身疾患の知識」

    第255回広島眼科症例検討会  2011年 

     詳細を見る

  • ベーチェット病

    ベーチェット病友の会岡山県支部医療講演  2011年 

     詳細を見る

  • 炎症と病理診断された硝子体混濁の免疫染色特徴

    第115回 日本眼科学会総会  2011年 

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  • 人工網膜埋め込み手術前の網膜評価に光干渉断層計は使えるか?

    第48回日本人工臓器学会大会  2010年 

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  • ケルビンプローブによる岡山大学方式人工網膜の光誘起表面電位測定

    第114回日本眼科学会総会  2010年 

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  • 神経内分泌腫瘍(カルチノイド)外眼筋転移の臨床的特長

    第66回日本弱視斜視学会総会  2010年 

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  • 眼付属器の良性リンパ性病変におけるIgG4陽性と全身合併症との関連

    第64回日本臨床眼科学会  2010年 

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  • シンポジウム9「網膜を材料にした多角的アプローチによる組織細胞の姿を知る」人工網膜からみた網膜神経細胞の機能

    第114回日本解剖学会総会  2009年 

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  • 眼内悪性リンパ腫の病理診断確定後におけるPET/CTの役割

    台113会日本眼科学会総会  2009年 

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  • 眼・中枢神経系悪性リンパ腫のクローン解析

    第112回日本眼科学会総会  2009年 

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  • 視力、問診、小児科医診察の3歳児健康診査における屈折検査導入の是非

    第65回日本弱視斜視学会総会  2009年 

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  • 眼内悪性リンパ腫の硝子体手術セルブロックによる病理診断とPET/CTによる評価

    第49回日本リンパ網内系学会総会  2009年 

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  • 共同性斜視家系におけるインプリンティングを考慮したMODスコア解析による遺伝子座の同定

    日本人類遺伝学会第54回大会  2009年 

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  • シンポジウム6「感覚系・運動系人工臓器の最近の進歩」光電変換色素結合ポリエチレン・フィルム(岡山大学方式人工網膜)のケルビンプローブによる表面電位測定

    第47回日本人工臓器学会大会  2009年 

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  • 両側、再発、全身多発性眼付属器リンパ腫のクローン解析

    第63回日本臨床眼科学会  2009年 

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  • オーガナイズドセッション「ニューロエンジニアリング」 光電変換色素をつかった人工網膜(岡山大学方式人工網膜)の安全性および機能性評価

    第47回生体医工学会大会  2008年 

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  • 日本で報告された先天下直筋欠損16例の特徴と発症機序

    第64回日本弱視斜視学会総会  2008年 

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  • 斜視家系における斜視関連遺伝子座の全ゲノム連鎖解析

    日本人類遺伝学会第53回大会  2008年 

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  • 大学病院でのヤギー文書・画像による眼科診療管理と専用電子カルテの構築

    第62回日本臨床眼科学会  2008年 

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  • スペシャルセッション 日本発 人工臓器 光電変換色素を使った人工網膜(岡山大学方式人工網膜)の評価方法

    第46回日本人工臓器学会大会  2008年 

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  • Safety of photoelectric dye and dye-coupled polyethylene films as prototypes of Okayama University-type retinal prostheses

    2008 Annual Meeting of the Association for Research in Vision and Ophthalmology  2008年 

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  • Biological safety of photoelectric dye-coupled polyethylene films as prototypes of Okayama University-type retinal prostheses

    The 2nd Meeting of the International Federation for Artificial Organs  2007年 

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  • 硝子体切除物の遠心細胞塊によって診断した眼内悪性リンパ腫

    第111回日本眼科学会総会  2007年 

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  • The feasibility of photoelectric dye-coupled polyethylene films as retinal prostheses based on neuronal adn glial cell adhesion

    2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO)  2007年 

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  • Reprodicibility of prevalence rates of strabismus and amblyopia in Japanese elementary school children between the year 2003 and 2005 survey

    2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO)  2007年 

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  • 岡山県内の小学校児童における斜視および弱視の頻度調査の再現性

    第63回日本弱視斜視学会総会  2007年 

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  • 内眼炎における硝子体手術の適応と硝子体細胞診

    平成19年度 中国四国ブロック講習会  2007年 

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  • 全身濾胞性リンパ腫の16年後に発症した組織型が異なる眼かリンパ腫の2症例

    第61回日本臨床眼科学会総会  2007年 

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  • 網膜色素変性症患者における網膜層構造の光干渉断層計による観察

    第60回 日本臨床眼科学会  2006年 

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  • 光電変換色素を使った人工網膜

    日本人工視覚研究会 第2回人工視覚研究会  2006年 

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  • イブニングセニナー1「眼の一生」眼の再生医療に向けて考えてみよう これからの人工物 人工網膜は再生医療への橋渡しか?

    第5回日本再生医療学会総会  2006年 

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  • Duane症候群におけるSALL4遺伝子多型

    第110回日本眼科学会総会  2006年 

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  • The prevalence of strabismus at 1.5 and 3-year-old children in Okayama City, Japan, from 2000 to 2004

    The 2006 annual meeting of the Association for Research in Vision and Ophthalmology (ARVO)  2006年 

     詳細を見る

  • SALL4 gene polymorphisms in patients with Duane syndrome

    The 2006 annual meeting of the Association for Research in Vision and Ophthalmology (ARVO)  2006年 

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  • Mixed neuronal and glial colony formation on the surface of photoelectric dye-coupled polyethylene (Okayama University type retinal prosthesis)

    The 2006 annual meeting of the Association for Research in Vision and Ophthalmology (ARVO)  2006年 

     詳細を見る

  • Atomic force microscopic observation of treahalose-treated and dried corneal surface

    The 2006 annual meeting of the Association for Research in Vision and Ophthalmology (ARVO)  2006年 

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  • 岡山市の1歳6ヵ月児および3歳児健康診査における弱視・斜視の頻度

    第62回日本弱視斜視学会総会  2006年 

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  • 外斜視手術直後の重心位置および重心動揺度の変化

    第61回日本弱視斜視学会総会  2005年 

     詳細を見る

  • Cyclic tetrasaccharide prevents cataract formation in the lens in vitro

    The 2005 annual meeting of the Association for Research in Vision and Ophthalmology (ARVO)  2005年 

     詳細を見る

  • Evaluation of a strabismus susceptibility locus on chromosome 7p in Japanese pedigrees

    The 2005 annual meeting of the Association for Research in Vision and Ophthalmology (ARVO)  2005年 

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  • pANCA(MPO-ANCA)関連血管炎でみられる眼所見

    2005年 第59回日本臨床眼科学会  2005年 

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  • 人工神経・人工感覚器研究の新しい潮流 光電変換色素を使った人工網膜(岡山大学方式人工網膜)の試作品の開発

    第43回日本人工臓器学会大会  2005年 

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  • 先天上斜筋麻痺の患者におけるARIX遺伝子およびPHOX2B遺伝子の多型

    第109回日本眼科学会総会  2005年 

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  • Cell adhesiveness and the response of chick embryonic retinal neurons to photoelectric dye-coupled polyethylene films as a prototype of retinal prostheses

    The 2005 annual meeting of the Association for Research in Vision and Ophthalmology (ARVO)  2005年 

     詳細を見る

  • The prevalence of strabismus at 1.5 and 3-year-old children in Okayama City, Japan

    The 2005 annual meeting of the Association for Research in Vision and Ophthalmology (ARVO)  2005年 

     詳細を見る

  • Trehalose eyedrops in the treatment of dry eye syndrome

    105th Annual Meeting of the American Academy of Ophthalmology  2001年 

     詳細を見る

  • Trehalose protects corneal epithelial cells from death by desiccation

    Association for Research in Vision and Ophthalmology  2001年 

     詳細を見る

▼全件表示

Works(作品等)

  • 岡山大学方式人工網膜の開発の現況と今後の展開

    2007年

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    作品分類:芸術活動  

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受賞

  • 日本人工臓器学会 2014年度論文賞(広領域)

    2014年  

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    受賞国:日本国

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  • 2013年度 日本弱視斜視学会賞(弓削賞)

    2013年  

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    受賞国:日本国

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  • 日本眼科学会評議員会賞

    2007年  

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    受賞国:日本国

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  • 平成17年11月22日 岡山県ベンチャー・ビジネスプランコンテスト審査員特別賞

    2005年  

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    受賞国:日本国

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  • 平成8年度公益信託須田賞(日本緑内障学会賞)

    1997年  

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    受賞国:日本国

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  • 結城賞

    1994年  

     詳細を見る

    受賞国:日本国

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  • 日本弱視斜視学会賞(弓削賞)

    1989年  

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    受賞国:日本国

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  • 日本人工臓器学会 第50回大会論文中の最優秀論文Tominaga Award2013

     詳細を見る

    受賞国:日本国

    2103

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▼全件表示

 

担当授業科目

  • ヒューマンイノベーション・ヘルスケア科学概論 (2021年度) 前期  - その他

  • ヘルスケアサイエンス概論 (2021年度) 前期  - 金7~8

  • ヘルスシステム統合科学アドバンストインターンシップ (2021年度) 通年  - その他

  • ヘルスシステム統合科学専門英語 (2021年度) 後期  - その他

  • ヘルスシステム統合科学序論 (2021年度) 前期  - 金3~4

  • ヘルスシステム統合科学特別研究 (2021年度) 通年  - その他

  • ヘルスシステム統合科学総論I (2021年度) 前期  - その他

  • 技術表現発表学 (2021年度) 後期  - その他

  • 技術表現発表学 (2021年度) 後期  - その他

  • 機能修復医学 (2021年度) 前期  - その他

  • 機能修復医学特論 (2021年度) 前期  - 水7~8

  • 眼科学 (2021年度) 第1学期  - 火8,水1,水8,木8

  • ヒューマンイノベーション・ヘルスケア科学概論 (2020年度) 前期  - 金5,金6

  • ヘルスシステム統合科学アドバンストインターンシップ (2020年度) 通年  - その他

  • ヘルスシステム統合科学専門英語 (2020年度) 後期  - その他

  • ヘルスシステム統合科学特別研究 (2020年度) 通年  - その他

  • ヘルスシステム統合科学総論I (2020年度) 前期  - 金3,金4

  • 技術表現発表学 (2020年度) 後期  - その他

  • 機能修復医学 (2020年度) 前期  - その他

  • 機能修復医学特論 (2020年度) 前期  - 水7,水8

  • 眼科学 (2020年度) 第1学期  - 火8,水1,水8,木8

  • 眼科学I(演習・実習) (2020年度) 特別  - その他

  • 眼科学I(講義・演習) (2020年度) 特別  - その他

  • 眼科学II(演習・実習) (2020年度) 特別  - その他

  • 眼科学II(講義・演習) (2020年度) 特別  - その他

▼全件表示