Updated on 2025/06/11

写真a

 
MATSUO Toshihiko
 
Organization
Faculty of Interdisciplinary Science and Engineering in Health Systems Professor
Position
Professor
Profile
網膜硝子体手術、ぶどう膜炎(全身疾患)、小児眼科、眼腫瘍を専門領域として診療する眼科専門医です。研究は、光電変換色素結合薄膜型の人工網膜(OUReP)の開発研究、斜視の分子遺伝学、トレハロース点眼薬の開発が主要テーマです。人工網膜開発では、2013年からPMDAと戦略相談を繰り返し医師主導治験を準備しています。斜視の分子遺伝学では、全染色体マッピング、SNP解析を行い、遺伝統計学の手法を使って斜視関連遺伝子を特定しています。トレハロース点眼薬は一般薬としてフランスの製薬会社Theaからヨーロッパ市場で販売されています。
External link

Degree

  • 医学博士

Research Interests

  • vitreoretinal diseases

  • vitrectomy (vitreous surgery)

  • molecular genetics (strabismus)

  • uveitis

  • trehalose

  • retinal prosthesis

  • ophthalmic tumors (neoplasms) and pathology

  • pediatric ophthalmology

  • 硝子体手術

  • ぶどう膜炎

  • 網膜硝子体疾患

  • 人工網膜

  • 分子遺伝学

  • 小児眼科

  • トレハロース

  • 眼腫瘍

Research Areas

  • Life Science / Ophthalmology

Education

  • Okayama University   医学研究科   外科系眼科学

    - 1989

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    Country: Japan

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  • Okayama University    

    - 1989

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  • Okayama University   医学部   医学科

    - 1985

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    Country: Japan

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  • Okayama University    

    - 1985

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Research History

  • - Associate Professor,Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama University

    2004

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  • - 岡山大学医歯薬学総合研究科 准教授

    2004

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  • University of British Columbia, Vancouver, Canada 博士研究員

    1992 - 1994

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  • Postdoctoral fellow (Medical Research Council of Canada),University of British Columbia, Vancouver, Canada

    1992 - 1994

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  • University of British Columbia, Vancouver, Canada 博士研究員

    1990 - 1991

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  • Postdoctoral fellow (Medical Research Council of Canada),University of British Columbia, Vancouver, Canada

    1990 - 1991

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  • - Educational Commission for Foreign Medical Graduates (ECFMG) 外国人医師用のアメリカ医師免許

    1986

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Professional Memberships

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Committee Memberships

  • 日本人工臓器学会   評議員  

    2015   

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    Committee type:Academic society

    日本人工臓器学会

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  • 日本再生医療学会   再生医療認定医  

    2014   

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    Committee type:Academic society

    日本再生医療学会

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  • 日本弱視斜視学会   弱視・斜視を専門とする医師 (学会ホームページ掲載)  

    2013   

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    Committee type:Academic society

    日本弱視斜視学会

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  • 日本小児眼科学会   小児眼科を専門とする医師 (学会ホームページ掲載)  

    2013   

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    日本小児眼科学会

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  • 日本眼科学会   評議員  

    2011   

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    Committee type:Academic society

    日本眼科学会

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  • 日本弱視斜視学会   理事  

    2010 - 2013   

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    Committee type:Academic society

    日本弱視斜視学会

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  • 日本ドライアイ研究会   ドライアイ診療に詳しい医師 (学会ホームページ掲載)  

    2010   

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    Committee type:Academic society

    日本ドライアイ研究会

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  • 日本眼科学会   評議員  

    2003   

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    Committee type:Academic society

    日本眼科学会

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  • 日本眼炎症学会   理事  

    1997 - 2003   

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    日本眼炎症学会

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Papers

  • Whole-Eye Radiation for the Local Control of Choroidal Lymphoma in Primary Central Nervous System Lymphoma: A 14-Year Case Study Reviewed

    Toshihiko Matsuo, Tomofumi Yano, Kotaro Yoshio, Takehiro Tanaka, Hirotake Nishimura, Ken-ichi Matsuoka

    Cureus   17 ( 6 )   e85680   2025.6

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)  

    File: Cureus radiation for intraocular lymphoma.pdf

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  • Detailed Ophthalmic and Pathological Features of Choroidal Metastasis From Breast Cancer: A Case Series of Five Patients. Reviewed

    Toshihiko Matsuo, Takehiro Tanaka, Tadahiko Shien, Atsushi Muraoka, Hiroyoshi Doihara

    Cureus   17 ( 5 )   e83484   2025.5

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    File: Cureus breast cancer choroidal met2025.pdf

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  • Nephronophthisis and Retinitis Pigmentosa (Senior-Loken Syndrome) After Living-Donor Kidney Transplantation: Twelve-Year Follow-Up in a Young Woman Reviewed

    Toshihiko Matsuo, Yasuhiro Onishi, Hiroshi Morinaga, Jun Wada, Takehiro Tanaka, Motoo Araki

    16 ( 5 )   164 - 173   2025.5

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    File: Senior-Loken Matsuo.pdf

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  • Bilateral Scleritis and Neutrophilic Dermatosis With Cytogenetic Chromosomal Aberrancy Related to Pyoderma Gangrenosum: A Case Report of a 20-Year Follow-Up Reviewed

    Toshihiko Matsuo, Takehiro Tanaka, Noboru Asada, Mikako Obika, Ryotaro Omichi, Keiji Iwatsuki

    Cureus   17 ( 4 )   e82348   2025.4

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)  

    File: Cureus2025 pyoderma scleritis.pdf

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  • Presumed Autoimmune Keratitis in Both Eyes Without Systemic Manifestations: A 40-Year Course of a Patient With Corneal Infiltrates and Melt Reviewed

    Toshihiko Matsuo, Takehiro Tanaka

    Cureus   17 ( 2 )   e79852   2025.3

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    File: Cureus2025-autoimmune-keratitis.pdf

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  • A Natural Course From Primary Intraocular Lymphoma to Brain Lymphoma in Four Years According to Patient's Choice Reviewed

    Toshihiko Matsuo, Takehiro Tanaka, Joji Ishida, Shotaro Kondo, Ken-ichi Matsuoka

    Cureus   17 ( 3 )   e81476   2025.3

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)  

    File: Cureus Intraocular lymphoma Matsuo.pdf

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  • Eyelid Spindle Cell Lipoma: Case Report and Review of Three Patients in Literature Reviewed

    Toshihiko Matsuo, Kiyoshi Yamada, Yasumasa Monobe, Takehiro Tanaka

    Clinical Case Reports   13 ( e70097 )   1 - 4   2025.1

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)  

    File: Clin Case Rep Eyelid Spindle Cell Lipoma.pdf

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  • Local Control of Conjunctival Malignant Melanoma by Proton Beam Therapy in a Patient With No Metastasis in Six Years From in Situ to Nodular Lesions. Reviewed

    Toshihiko Matsuo, Takeshi Ogata, Takahiro Waki, Takehiro Tanaka, Kota Tachibana, Tomokazu Fuji, Takuya Adachi, Osamu Yamasaki

    Journal of Medical Cases   16 ( 1 )   28 - 36   2025.1

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)  

    File: jmc4351 melanoma protom beam.pdf

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  • Perspectives of traditional herbal medicines in treating retinitis pigmentosa Reviewed

    Shihui Liu, Toshihiko Matsuo, Chie Matsuo, Takumi Abe, Jinghua Chen, Chi Sun, Qing Zhao

    Frontiers in Medicine   11 ( 1468230 )   2024.12

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    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)  

    File: front Med Kampo Liu2024.pdf

    DOI: 10.3389/fmed.2024.1468230

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  • Axillary Reactive Lymphoid Hyperplasia, Likely Due to Unicentric Castleman Disease, and the Concurrent Presence of Orbital Mucosa- Associated Lymphoid Tissue (MALT) Lymphoma: A Six-Year Follow-Up Study. Reviewed

    Toshihiko Matsuo, Takehiro Tanaka, Tomokazu Fuji, Daisuke Ennishi

    Cureus   16 ( 11 )   e73775   2024.11

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  • Infective Endocarditis With Origin in Orbital Vascular Malformation and Maxillary Sinusitis: A Case Report and Review of Four Patients in the Literature Reviewed

    Toshihiko Matsuo, Yoshitaka Iwamoto, Hironori Okamoto, Daisuke Iguchi

    Cureus   16 ( 11 )   e74873   2024.11

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    File: Cureus infective endocarditis 2024.pdf

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  • Presumed Choroidopathy of IgG4-Related Disease Discovered During 16-Year Follow-Up of a Patient With Polycystic Kidney Disease. Reviewed

    Toshihiko Matsuo, Takehiro Tanaka, Kenji Tsuji

    Cureus   16(10) ( e70865 )   1 - 5   2024.10

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    File: Cureus choroidopathy-of-IgG4.pdf

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  • Intravitreal Fluconazole Injection for Fungal Endophthalmitis as Treatment Option in a Patient With End-Stage Liver and Kidney Diseases. Reviewed

    Toshihiko Matsuo, Yasuyuki Kobayashi, Shingo Nishimura, Naoko Yoshioka, Yasushi Takahashi, Yasutaka Iguchi

    Journal of Medical Cases   15 ( 11 )   359 - 366   2024.10

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    File: Fungal endophthalmitis JMedCases.pdf

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  • Pathological findings in enucleated eyes of patients with neurofibromatosis type 1: report of a case with 15-year follow-up and review of 14 patients in the literature. Reviewed

    Toshihiko Matsuo, Kenji Nishida, Takehiro Tanaka, Takaya Seno, Kiyoshi Yamada, Shigeki Ono

    BMC Ophthalmology   24 ( 341 )   1 - 13   2024.8

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    File: BMC Ophthalmol neurofibromatosis -1.pdf

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  • Anterior Uveitis After Discontinuation of Janus Kinase Inhibitor, Ruxolitinib Reviewed

    Toshihiko Matsuo, Naoto Ikeda, Yasumasa Monobe, Takehiro Tanaka

    Journal of Medical cases   15 ( 8 )   208 - 214   2024.8

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)  

    File: J Med Cases myelofibrosis.pdf

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  • Genome-Wide Association Study with Three Control Cohorts of Japanese Patients with Esotropia and Exotropia of Comitant Strabismus and Idiopathic Superior Oblique Muscle Palsy Reviewed

    Toshihiko Matsuo, Ichiro Hamasaki, Yoichiro Kamatani, Takahisa Kawaguchi, Izumi Yamaguchi, Fumihiko Matsuda, Akira Saito, Kazuyuki Nakazono, Shigeo Kamitsuji

    International Journal of Molecular Sciences   25 ( 6986 )   1 - 25   2024.6

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)  

    File: ijms-25-06986 strabismus GWAS.pdf

    DOI: 10.3390/ijms25136986

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  • Decades of stability of conjunctival vascular malformations in two patients. Reviewed

    Toshihiko Matsuo, Takehiro Tanaka, Yoshihiro Kimata

    Clinical Case Reports   12 ( e8933 )   1 - 7   2024.5

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    File: ClinCaseRep conjunctival vascular malformations.pdf

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  • Spontaneous regression and rare relapse after excisional biopsy in long-term observation of 31 patients with primary conjunctival lymphoma. Reviewed

    Toshihiko Matsuo, Takehiro Tanaka

    Journal of Clinical and Experimental Hematopathology   64 ( 2 )   86 - 96   2024.5

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)  

    File: JCEH conj lymphoma2024.pdf

    DOI: 10.3960/jslrt.24002

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  • Pericardial Effusion in Association With Periodontitis: Case Report and Review of 8 Patients in Literature. Reviewed

    Toshihiko Matsuo, Chie Nakago Matsuo, Nobuhiko Matsuo, Ayano Mori, Masaaki Murakami, Hiroshi Ito

    Journal of Investigative Medicine High Impact Case Reports   12 ( 23247096241239559 )   1 - 8   2024.3

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    File: JIM2024 pericarditis and periodontitis.pdf

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  • Vogt-Koyanagi- Harada disease in pregnancy: Case report and review of 32 patients in the literature. Reviewed

    Toshihiko Matsuo, Kasumi Takahashi, Tsunemasa Kondo

    Clinical Case Reports   12 ( e8643 )   1 - 12   2024.3

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    File: Clinical Case Reports Harada in pregnancy.pdf

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  • sarcoidosis-lymphoma 症候群 Invited

    松尾俊彦

    「別冊日本臨床 血液症候群(第3版)IV その他の血液疾患を含めて   29   413 - 417   2024.2

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    Authorship:Lead author   Publishing type:Part of collection (book)  

    File: 日本臨牀(別冊)血液症候群(第3版)松尾sarcoidosis-lymphoma IVB2402085.pdf

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  • Rare Combination of Abducens Nerve Palsy and Optic Neuritis on the Same Side: Case Report and Review of 8 Patients in Literature. Reviewed

    Toshihiko Matsuo, Daisuke Iguchi

    Journal of Investigative Medicine High Impact Case Reports   12 ( 23247096231225873 )   1 - 7   2024.1

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    File: optic neuritis & abducens palsy.pdf

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  • Morphometric Analysis of the Eye by Magnetic Resonance Imaging in MGST2-Gene-Deficient Mice. Reviewed

    Chaomulige, Toshihiko Matsuo, Kohei Sugimoto, Mary Miyaji, Osamu Hosoya, Masashi Ueda, Ryosuke Kobayashi, Takuro Horii, Izuho Hatada

    Biomedicines   12 ( 370 )   1 - 14   2024.1

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    File: biomedicines-12-00370.pdf

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  • [Relapsed primary central nervous system lymphoma treated with CD19 chimeric antigen receptor T-cell therapy and allogeneic hematopoietic stem cell transplantation]. Reviewed

    Fuminari Fujii, Toshiki Terao, Hisakazu Nishimori, Kentaro Fujii, Toshihiko Matsuo, Tadashi Yoshino, Hiroko Ueda, Tadashi Oyama, Akifumi Matsumura, Kaho Kondo, Chisato Matsubara, Kanako Fujiwara, Keisuke Seike, Hideaki Fujiwara, Noboru Asada, Daisuke Ennishi, Keiko Fujii, Nobuharu Fujii, Ken-Ichi Matsuoka, Yoshinobu Maeda

    [Rinsho ketsueki] The Japanese journal of clinical hematology   65 ( 7 )   622 - 627   2024

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    Relapsed and/or refractory (R/R) primary central nervous system lymphoma (PCNSL) has a poor prognosis. A 57-year-old man diagnosed with PCNSL achieved a complete response by high-dose methotrexate-based chemotherapy followed by autologous hematopoietic stem cell transplantation (ASCT). The disease was not cured, so he was treated with the anti-CD19 chimeric antigen receptor (CAR) T-cell therapy tisagenlecleucel after the third relapse. However, the disease relapsed again 28 days after CAR T-cell therapy. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) was attempted as curative therapy after bridging with second ASCT and tirabrutinib monotherapy. Although a temporary response was achieved, the disease relapsed 98 days after allo-HSCT. While receiving tirabrutinib for relapse after allo-HSCT, the patient developed acute respiratory failure due to transplant-related toxicity and post-transplant thrombotic microangiopathy. He died 175 days after allo-HSCT. Although various treatments for PCNSL have been investigated in recent years, the treatment strategy for R/R PCNSL has not been established. Further studies are warranted to improve the outcomes of patients with R/R PCNSL.

    DOI: 10.11406/rinketsu.65.622

    PubMed

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  • 特集 指定難病 Up to Date 網膜色素変性症 Invited Reviewed

    松尾俊彦

    岡山医学会雑誌   135 ( 3 )   147 - 151   2023.12

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  • Nontuberculous mycobacterial abscess of lacrimal sac and eyelid debridement: Case report Reviewed

    Toshihiko Matsuo, Takehiro Tanaka, Kiyoshi Yamada, Motoko Nose, Yasushi Tanimoto

    Clinical Case Reports   11 ( e8364 )   1 - 6   2023.12

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    File: Clinical Case Reports 2023NTM.pdf

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  • A simple method for culturing Acanthamoeba from soft contact lens at a clinical laboratory of a hospital: Case report of Acanthamoeba keratitis. Reviewed

    Toshihiko Matsuo, Motoko Nose

    Clinical Case Reports   11 ( e8248 )   1 - 5   2023.11

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  • Resection of Orbital Myxoma With Magnetic Resonance Imaging Evidence of Ethmoid Sinus Origin: Case Report and Review of 20 Patients in the Literature. Reviewed

    Toshihiko Matsuo, Takehiro Tanaka

    Journal of Investigative Medicine High Impact Case Reports   11 ( 10.1177/23247096231201013 )   1 - 6   2023.9

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    File: matsuo-tanaka-2023 orbital myxoma.pdf

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  • Bilateral lacrimal gland mantle cell lymphoma in 11-year follow-up: case report and review of 48 cases with ocular adnexal presentation in the literature. Reviewed

    Toshihiko Matsuo, Takehiro Tanaka, Kazuya Okada, Kenji Notohara, Keiko Fujii, Nobuharu Fujii

    Journal of Investigative Medicine High Impact Case Reports   11 ( 23247096231185483 )   2023.7

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)  

    File: matsuo-et-al-2023-lacrimal-gland-mantle-cell-lymphoma.pdf

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  • Bilateral Optic Neuritis and Hypophysitis With Diabetes Insipidus 1 Month After COVID-19 mRNA Vaccine: Case Report and Literature Review Reviewed

    Toshihiko Matsuo, Kohei Okubo, Hirofumi Mifune, Takeshi Imao

    Journal of Investigative Medicine High Impact Case Reports   11 ( 23247096231186046 )   1 - 10   2023.7

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)  

    File: matsuo-et-al-2023-bilateral-optic-neuritis-and-hypophysitis.pdf

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  • ANCA-associated vasculitis with scleritis, corneal melt, and perforation rescued by rituximab: Case report and literature review Reviewed

    Toshihiko Matsuo, Sumie Hiramatsu-Asano, Hiroshi Sawachika, Hirotake Nishimura

    Clinical Case Reports   11 ( e7595 )   1 - 8   2023.6

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    File: Clinical Case Reports 2023 Matsuo ANCA.pdf

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  • 両側涙腺原発マントル細胞リンパ腫に対する末梢血幹細胞移植後10年診た1例

    松尾 俊彦, 田中 健大, 岡田 和也, 能登原 憲司, 藤井 敬子, 藤井 伸治

    日本リンパ網内系学会会誌   63   126 - 126   2023.6

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    Language:Japanese   Publisher:(一社)日本リンパ網内系学会  

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  • Revisitng cyptocyanine dye, NK-4, as an old and new drug: review and future perspectives. Reviewed

    Shuihui Liu, Toshihiko Matsuo, Takumi Abe

    Internnational Journal of Molecular Sciences   24 ( 4411 )   1 - 14   2023.2

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    File: ijms-24-04411-v2 NK-4 review.pdf

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  • Revisiting Cryptocyanine Dye, NK-4, as an Old and New Drug: Review and Future Perspectives

    Shihui Liu, Toshihiko Matsuo, Takumi Abe

    International Journal of Molecular Sciences   2023.2

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijms24054411

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  • Are Prophylactic Systemic Antibiotics Required in Patients with Cataract Surgery at Local Anesthesia? Reviewed

    Toshihiko Matsuo, Masahiro Iguchi, Noriyasu Morisato, Tatsuya Murasako, Hideharu Hagiya

    International Journal of Environmental Research and Public Health   19 ( 15796 )   1 - 8   2022.11

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    File: cataract surgery ijerph-19-15796.pdf

    DOI: 10.3390/ijerph192315796

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  • Temporal association of vitreous hemorrhage and hypertension after COVID- 19 mRNA vaccines. Reviewed

    Toshihiko Matsuo, Hiroshi Noda

    Clinical Case Reports   10 ( e06657 )   1 - 3   2022.11

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    File: Clinical Case Reports - 2022 - Matsuo - Temporal association of vitreous hemorrhage and hypertension after COVID‐19 mRNA.pdf

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  • Traditional Chinese Medicines and Prescriptions Brought from China to Japan by a Monk (Jianzhen, Japanese: Ganjin): A Historical Review Reviewed

    Shihui Liu, Toshihiko Matsuo, Chie Matsuo, Takumi Abe

    Compounds   2 ( 4 )   267 - 284   2022.10

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:MDPI AG  

    (1) Background: Japanese Kampo medicine has its origin in ancient Chinese medicine. In 742, a Tang Dynasty monk named Jianzhen (Ganjin) was invited by Japanese clerics to visit Japan and teach commandments in Buddhism. Because of the dangers of the voyage and also other obstacles, he took 11 years to reach Japan on the sixth voyage and he was blind when he arrived in Japan. He was the first person in China to go to Japan to establish the Buddhism commandments, and he was also the first person in Japan to directly teach traditional Chinese medicine. Until now, there have been few reports in English about the details of the Chinese herbal medicines he brought to Japan, including the types of herbal medicines, pharmacological activities, and formulations. In the review, we systematically and comprehensively summarized Jianzhen’s life from the standpoint of his medical and pharmaceutical knowledge and the types and pharmacological activities of Chinese herbal medicines and prescriptions that were brought to Japan by Jianzhen; (2) Methods: A review was made on the relevant literature written by Chinese, Japanese, and English languages regarding the medical and pharmacological knowledge of Jianzhen, the 36 Chinese herbal medicines brought to Japan by Jianzhen, and the pharmacological and therapeutic effects of these 36 herbal medicines, as well as their formulations; (3) Results: The review of the literature proved that Jianzhen’s prescriptions served as a basis for current herbal medicines (Kampo) in Japan. In the process of the literature search, we found a book entitled Jianshangren (Holy Priest Jianzhen)’s Secret Prescription, which recorded the complete prescription of the 36 traditional Chinese medicines Jianzhen brought to Japan; (4) Conclusions: Jianzhen is one of the ancestors of traditional Chinese medicine/Kampo medicine, and he brought traditional Chinese medicine and medical books to Japan for patients. He made important contributions to the development of traditional Chinese medicine in Japan.

    File: compounds-02-00022.pdf

    DOI: 10.3390/compounds2040022

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  • Diffuse large B-cell lymphoma in the course of systemic sarcoidosis: A case report and review of 30 Japanese patients with sarcoidosis-lymphoma syndrome. Reviewed

    Toshihiko Matsuo, Takehiro Tanaka, Rika Omote, Toshiaki Okada, Kenji Notohara, Kazuya Okada

    Journal of Clinical and Experimental Hematopathology   62 ( 4 )   22 - 237   2022.9

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    File: JCEH sarcoidosis and lymphoma2022.pdf

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  • Candidate Genes in Testing Strategies for Linkage Analysis and Bioinformatic Sorting of Whole Genome Sequencing Data in Three Small Japanese Families with Idiopathic Superior Oblique Muscle Palsy Reviewed

    Toshihiko Matsuo, Chaomulige, Mary Miyaji, Osamu Hosoya, Akira Saito, Kazuyuki Nakazono

    International Journal of Molecular Sciences   23 ( 8626 )   1 - 16   2022.8

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:MDPI AG  

    Idiopathic superior oblique muscle palsy is a major type of paralytic, non-comitant strabismus and presents vertical and cyclo-torsional deviation of one eye against the other eye, with a large vertical fusion range and abnormal head posture such as head tilt. Genetic background is considered to play a role in its development, as patients with idiopathic superior oblique muscle palsy have varying degrees of muscle hypoplasia and, rarely, the complete absence of the muscle, that is, aplasia. In this study, whole genome sequencing was performed, and single nucleotide variations and short insertions/deletions (SNVs/InDels) were annotated in two patients each in three small families (six patients in total) with idiopathic superior oblique muscle palsy, in addition to three normal individuals in one family. At first, linkage analysis was carried out in the three families and SNVs/InDels in chromosomal loci with negative LOD scores were excluded. Next, SNVs/InDels shared by the six patients, but not by the three normal individuals, were chosen. SNVs/InDels were further narrowed down by choosing low-frequency (<1%) or non-registered SNVs/InDels in four databases for the Japanese population, and then by choosing SNVs/InDels with functional influence, leading to one candidate gene, SSTR5-AS1 in chromosome 16. The six patients were heterozygous for 13-nucleotide deletion in SSTR5-AS1, except for one homozygous patient, while the three normal individuals were wild type. Targeted polymerase chain reaction (PCR) and direct sequencing of PCR products confirmed the 13-nucleotide deletion in SSTR5-AS1. In the face of newly-registered SSTR5-AS1 13-nucleotide deletion at a higher frequency in a latest released database for the Japanese population, the skipping of low-frequency and non-registration sorting still resulted in only 13 candidate genes including SSTR5-AS1 as common variants. The skipping of linkage analysis also led to the same set of 13 candidate genes. Different testing strategies that consisted of linkage analysis and simple unintentional bioinformatics could reach candidate genes in three small families with idiopathic superior oblique muscle palsy.

    File: SO palsy WGS final ijms-23-08626.pdf

    DOI: 10.3390/ijms23158626

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  • CD19 immunostaining of a stored paraffin-embedded vitrectomy cell block of intraocular lymphoma contributing to chimera antigen receptor T-cell therapy. Reviewed

    Matsuo T, Tanaka T, Fujii N, Fujii K, Kondo E

    Journal of Clinical and Experimental Hematopathology   62 ( 3 )   187 - 189   2022.8

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    File: JCEH2022 CAR-T.pdf

    DOI: 10.3960/jslrt.22007.

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  • Photorefraction with Spot Vision Screener versus Visual Acuity Testing as Community-Based Preschool Vision Screening at the Age of 3.5 Years in Japan

    Toshihiko Matsuo, Chie Matsuo, Masami Kayano, Aya Mitsufuji, Chiyori Satou, Hiroaki Matsuoka

    International Journal of Environmental Research and Public Health   19 ( 8655 )   1 - 15   2022.7

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    File: ijerph-19-08655.pdf

    DOI: 10.3390/ijerph19148655

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  • 人工臓器の最前線vol.3「光電変換色素薄膜型の人工網膜OUReP(オーレップ) Invited

    松尾俊彦, 内田哲也, 石金浩史

    医学のあゆみ   282 ( 4 )   304 - 312   2022.7

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    File: 医学のあゆみ 3光電変換色素薄膜型の人工網膜OUReP(オーレップ)松尾俊彦.pdf

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  • モンゴル伝統医学とその現代的意義

    梶井一暁, 包雪峰, 朝木力格, 松尾俊彦, 白烏日罕

    岡山大学大学院教育学研究科研究集録   180 ( 1 )   1 - 8   2022.6

  • サルコイドーシス経過中にびまん性大細胞B細胞リンパ腫を発症した1例

    松尾 俊彦, 田中 健大, 表 梨華, 岡田 俊明, 能登原 憲司, 岡田 和也

    日本リンパ網内系学会会誌   62   93 - 93   2022.6

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  • Whole exome-sequencing of pooled genomic DNA samples to detect quantitative trait loci in esotropia and exotropia of stra-bismus in Japanese. Reviewed

    Zhang J, Matsuo T, Hamasaki I, Sato K

    Life   12 ( 41 )   1 - 12   2022.1

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    File: life-12-00041.pdf

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  • Proton Beam Therapy Followed by Pembrolizumab for Giant Ocular Surface Conjunctival Malignant Melanoma: Case Report. Reviewed

    Matsuo T, Yamasaki O, Tanaka T, Katsui K, Waki T

    Molecular and Clinical Oncology   16 ( 12 )   1 - 5   2022.1

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    File: Mol Clin Oncol2021 proton beam.pdf

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  • COVID-19 mRNA Vaccine–Associated Uveitis Leading to Diagnosis of Sarcoidosis: Case Report and Review of Literature Reviewed International journal

    Toshihiko Matsuo, Hiroyuki Honda, Takehiro Tanaka, Kensuke Uraguchi, Masaaki Kawahara, Hideharu Hagiya

    Journal of Investigative Medicine High Impact Case Reports   10   232470962210864 - 232470962210864   2022.1

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    A 34-year-old Japanese person with male gender identity who had been taking intramuscular injection of methyltestosterone depot for 11 years after bilateral mastectomy noticed blurred vision 5 days after the second vaccination for COVID-19 (Tozinameran; Pfizer-BioNTech) in the interval of 3 weeks following the first vaccination. The patient was diagnosed as granulomatous iritis with mutton-fat keratic precipitates and small iris nodules at the pupillary margin in the right eye and began to have 0.1% betamethasone eye drops with good response. The patient, however, continued to have fever and malaise and showed a high level of serum soluble interleukin-2 receptor (sIL-2R) even 4 weeks after the second vaccination. Computed tomographic scan disclosed mediastinal and bilateral hilar small lymphadenopathy together with limited granular lesion in the right lung. Gallium-67 scintigraphy demonstrated high uptake not only in mediastinal and hilar lymph nodes but also in bilateral parotid glands. Right parotid gland biopsy revealed noncaseating granulomas and proved pathological diagnosis of sarcoidosis. The systemic symptoms were relieved by oral prednisolone 20 mg daily. Even though the causal relationship remains undetermined, this case is unique at the point that vaccine-associated uveitis led to the detection of pulmonary lesions and lymphadenopathy, resulting in clinical and pathological diagnosis of sarcoidosis. In literature review, 3 patients showed sarcoidosis-like diseases after COVID-19 vaccination: 2 patients were diagnosed clinically as Lofgren syndrome with acute onset of erythema nodosum and ankle swelling, with or without mediastinal and hilar lymphadenopathy, whereas 1 patient with mediastinal lymphadenopathy but no uveitis was diagnosed pathologically by biopsy as sarcoidosis.

    File: JIM High Inpact CaseRep Coronavirus vacciation.pdf

    DOI: 10.1177/23247096221086450

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    Other Link: http://journals.sagepub.com/doi/full-xml/10.1177/23247096221086450

  • Effect of NK-5962 on Gene Expression Profiling of Retina in a Rat Model of Retinitis Pigmentosa Reviewed

    Shihui Liu, Mary Miyaji, Osamu Hosoya, Toshihiko Matsuo

    International Journal of Molecular Sciences   22 ( 13276 )   1 - 16   2021.12

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    File: ijms-22-13276NK-5962.pdf

    DOI: 10.3390/ijms222413276

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  • Diffuse large B-cell lymphoma 18 years after bilateral lacrimal gland IgG4-related disease: case report and literature review. Reviewed

    Matsuo T, Tanaka T, Notohara K, Okada K

    Journal of Investigative Medicine High Impact Case Reports   10 ( DOI:10.1177/23247096211067894 )   1 - 10   2021.12

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  • Bilateral Optic Disc Swelling as a Plausible Common Ocular Sign of Autoinflammatory Diseases: Report of Three Patients with Blau Syndrome or Cryopyrin-Associated Periodic Syndrome. Reviewed International journal

    Toshihiko Matsuo, Masato Yashiro, Osamu Yamasaki, Takehiro Tanaka, Akira Manki

    Life (Basel, Switzerland)   11 ( 1433 )   2021.12

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    The aim of this study is to describe bilateral optic disc swelling in three consecutive patients with Blau syndrome or cryopyrin-associated periodic syndrome at a single institution. Case 1 was a 30-year-old woman receiving 25 mg etanercept twice weekly who had been diagnosed as early-onset sarcoidosis by biopsy of skin rashes at 5 months old and genetically diagnosed with Blau syndrome with CARD15/NOD2 mutation (N670K) at 13 years old. At 10 years old, she began to have uveitis with optic disc swelling in both eyes, resulting in macular degeneration and optic disc atrophy at 17 years old only when etanercept was introduced. Case 2 was a 21-year-old man receiving adalimumab every 2 weeks who had been diagnosed as early-onset sarcoidosis by biopsy of skin rashes at 1.5 years old and genetically diagnosed as Blau syndrome with CARD15/NOD2 mutation (C495Y) at 5 years old. At 8 years old, around the time of adalimumab introduction, he began to show bilateral optic disc swelling which continued until the age of 16 years when the dose of adalimumab was increased. Case 3 was a 20-year-old woman receiving canakinumab every 8 weeks for systemic symptoms such as fever, headache, vomiting, and abdominal pain and later for sensorineural hearing disturbance on both sides. She had been diagnosed genetically with cryopyrin-associated periodic syndrome with NLRP3 mutation (Y859C) at 7 years old. At 5 years old, she was found to have bilateral optic disc swelling, which continued until the age of 10 years when she began receiving canakinumab (IL-1β inhibitor). Bilateral optic disc swelling might be tentatively designated as a plausible common ocular feature, if it occurred, in autoinflammatory diseases to pay more attention to ophthalmic complications in rare diseases.

    File: life-11-01433.pdf

    DOI: 10.3390/life11121433

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  • Whole Exome-Sequencing of Pooled Genomic DNA Samples to Detect Quantitative Trait Loci in Esotropia and Exotropia of Strabismus in Japanese

    Jingjing Zhang, Toshihiko Matsuo, Ichiro Hamasaki, Kazuhiro Sato

    Life   2021.12

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    DOI: 10.3390/life12010041

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  • Clarification of degradation mechanism on retinal prosthesis using photoelectric dyes coupled to polyethylene film by mass spectrometry. Reviewed

    Koichiro Yamashita, Mayu Mitui, Toshihiko Matsuo, Tetsuya Uchida

    Materials Letters   307(2022) ( 130978 )   1 - 4   2021.10

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    File: materials Letters2021Yamashita.pdf

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  • Accuracy of deep learning algorithms for the diagnosis of retinopathy of prematurity by fundus images: systematic review and meta-analysis. Reviewed

    Jingjing Zhang, Yangyang Liu, Toshiharu Mitsuhashi, Toshihiko Matsuo

    Journal of Ophthalmology   2021 ( 8883946 )   1 - 11   2021.8

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    File: ZhangJingjing ROP2021 J Ophthalmol.pdf

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  • Alcohol Consumption and Age related Macular Degeneration: A Systematic Review and Dose response Meta analysis. Reviewed

    Jingjing Zhang, Toshiharu Mitsuhashi, Toshihiko Matsuo, Takashi Yorifuji, Jun Hamada, Yangyang Liu

    Current Eye Research   2021.7

  • The Effect of Cyanine Dye NK-4 on Photoreceptor Degeneration in a Rat Model of Early-Stage Retinitis Pigmentosa Reviewed

    Shihui Liu, Toshihiko Matsuo, Mary Miyaji, Osamu Hosoya

    Pharmaceuticals   14 ( 694 )   1 - 14   2021.7

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    File: pharmaceuticals-14-00694-v3.pdf

    DOI: 10.3390/ph14070694

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  • Photoelectric Dye, NK-5962, as a Potential Drug for Preventing Retinal Neurons from Apoptosis: Pharmacokinetic Studies Based on Review of the Evidence. Reviewed International journal

    Toshihiko Matsuo, Shihui Liu, Tetsuya Uchida, Satomi Onoue, Shinsaku Nakagawa, Mayumi Ishii, Kayoko Kanamitsu

    Life (Basel, Switzerland)   11 ( 591 )   1 - 19   2021.6

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    NK-5962 is a key component of photoelectric dye-based retinal prosthesis (OUReP). In testing the safety and efficacy, NK-5962 was safe in all tests for the biological evaluation of medical devices (ISO 10993) and effective in preventing retinal cells from death even under dark conditions. The long-term implantation of the photoelectric dye-coupled polyethylene film in the subretinal space of hereditary retinal dystrophic (RCS) rats prevented neurons from apoptosis in the adjacent retinal tissue. The intravitreous injection of NK-5962 in the eyes of RCS rats, indeed, reduced the number of apoptotic cells in the retinal outer nuclear layer irrespective of light or dark conditions. In this study, we reviewed the in vitro and in vivo evidence of neuroprotective effect of NK-5962 and designed pharmacokinetic experiments. The in vitro IC50 of 1.7 μM, based on the protective effect on retinal cells in culture, could explain the in vivo EC50 of 3 μM that is calculated from concentrations of intravitreous injection to prevent retinal neurons from apoptosis. Pharmacokinetics of NK-5962 showed that intravenous administration, but not oral administration, led to the effective concentration in the eye of rats. NK-5962 would be a candidate drug for delaying the deterioration of retinal dystrophy, such as retinitis pigmentosa.

    File: life-11-00591.pdf

    DOI: 10.3390/life11060591

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  • Prostate cancer detected by choroidal tumor and complete response to hormonal therapy: Case report and literature review of 24 patients with choroidal metastasis from prostate cancer. Reviewed

    Matsuo T, Tanaka T, Nakamura A, Wada K

    Journal of Investigative Medicine High Impact Case Reports   9 ( 23247096211026471 )   1 - 8   2021.6

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    File: Prostate Ca2021.pdf

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  • 両側涙腺IgG4関連疾患の18年後に発症した全身のびまん性大細胞B細胞リンパ腫

    松尾 俊彦, 田中 健大, 岡田 和也, 能登原 憲司

    日本リンパ網内系学会会誌   61   91 - 91   2021.5

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  • Development and chemical properties of retinal prostheses using photoelectric dyes coupled to polyethylene films with various anions to achieve high durability. Reviewed

    Yamashita K, Tanaka T, Matsuo T, Uchida T

    Polymer Journal   53   719 - 729   2021.4

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    File: PJ2021OUReP.pdf

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  • Modelling the visual response to an OUReP retinal prosthesis with photoelectric dye coupled to polyethylene film. Reviewed

    Koichiro Yamashita, Prathima Sundaram, Tetsuya Uchida, Toshihiko Matsuo, Willy Wong

    Journal of Neural Engineering   18 ( 045006 )   1 - 14   2021.4

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    File: J Neural Eng2021.pdf

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  • Development of highly durable retinal prosthesis using photolectric dyes coupled to polyethylene film and quantitative in vitro evaluation of its durability. Reviewed

    Yamashita K, Tanaka T, Matsuo T, Uchida T

    Biomedical Materials   16 ( 4 )   045001   2021.4

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    File: bmm_16_4_045001.pdf

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  • Television-watching in the early years of life and the association with parents’ concerns about decreased visual acuity in their elementary school-aged child: results of a nationwide population-based longitudinal survey of Japan. Reviewed

    Matsuo T, Yorifuji T

    Japanese Journal of Ophthalmology   65   561 - 568   2021.3

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    File: JJO 21st century final202106.pdf

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  • Follow-up with serum IgG4-monitoring in 8 patients with IgG4-related disease diagnosed by a lacrimal gland mass. Reviewed

    Toshihiko Matsuo, Takehiro Tanaka, Yasuharu Sato, Hitomi Kataoka, Mayu Uka, Daisuke Ennishi, Tomofumi Yano

    Journal of clinical and experimental hematopathology : JCEH   61 ( 1 )   10 - 21   2021.3

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    The diagnostic criteria for IgG4-related disease were previously published and serum IgG4 measurement has been reimbursed by national health insurance in Japan since 2012. Eight patients diagnosed with IgG4-related disease based on lacrimal gland masses were retrospectively reviewed. The 8 patients were 3 men and 5 women ranging in age from 52 to 77 (median, 63) years at the initial visit and their follow-up period ranged from 0.25 to 11 (median, 7) years. Bilateral and unilateral involvement were noted in 4 patients each; 2 on the right side and 2 on the left side in those with unilateral involvement. Serum IgG4 was high in 5 of 8 patients at the initial visit. Five patients with no systemic signs were followed without treatment, whereas oral steroids were administered and tapered in the other 3 patients who exhibited systemic signs. One patient with a history of radiation for MALT lymphoma in bilateral lacrimal glands developed IgG4-related disease in the left lacrimal gland 10 years later and was followed without treatment. Nine years later, her serum IgG4 level increased to 1500 mg/dL and paracardiac lesions, found on positron emission tomography, were confirmed to be MALT lymphoma by needle biopsy, leading to systemic chemotherapy. The other 7 patients had neither local recurrence nor additional systemic signs. Serum IgG4 monitoring may be useful to detect systemic complications in IgG4-related ophthalmic disease and markedly high serum IgG4 levels may indicate new lymphoma at other sites.

    File: JCEH IgG42021.pdf

    DOI: 10.3960/jslrt.20048

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  • 「2-12. 人工網膜」テクノロジー・ロードマップ2021-2030 医療・健康・食農編 Invited

    松尾俊彦, 内田哲也

    テクノロジー・ロードマップ2021-2030 医療・健康・食農編 日経BP   226 - 229   2021.2

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    File: 人工網膜TechnologyRoadMap2021-30.pdf

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  • Photoelectric dye-based retinal prosthesis (OUReP) as a novel type of artificial retina Invited Reviewed

    Toshihiko Matsuo, Tetsuya Unchida

    Internal Medicine Review   7 ( 1(916) )   1 - 17   2021.1

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    File: 916-Photoelectric dye-based retinal prosthesis (1).pdf

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  • Pathologically-proven intraocular infiltration with adult T-cell leukemia/lymphoma: two new cases with either vitreous opacity or aqueous hypopyon and literature review of 16 cases. Reviewed

    Matsuo T, Shimizu T, Tanaka T, Yamamoto A, Takasuka H

    Journal of Investigative Medicine High Inpact Case Reports   8   1 - 8   2020.10

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    File: ATL eye J Invest Med HIgh Inpact Case Rep2020.pdf

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  • Curved-Tip Disposable Injector (OUReP Injector) to Insert Photoelectric Dye-Coupled Polyethylene Film (OUReP) as Retinal Prosthesis into Subretinal Space of Rabbit Eyes. Reviewed

    Toshihiko Matsuo, Chie Matsuo, Tetsuya Uchida, Koichiro Yamashita, Tenu Tanaka, Yusuke Kawakami, Toshiya Hitomi, Kanji Taga, Tatsuya Sanada, Yusuke Yamashita

    Journal of Surgical Techniques and Procedures   4 ( 1040 )   1 - 6   2020.9

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  • Long-term control of macular edema with adalimumab after cataract surgery in a Japanese child with juvenile idiopathic arthritis: case report and review of 26 Japanese patients. Reviewed

    Toshihiko Matsuo, Masato Yashiro

    Journal of Investigative Medicine High Inpact Case Reports   8   1 - 10   2020.8

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    File: JIA case J InvestMed High Impact Case Rep2020.pdf

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  • Step-by-Step Procedure to Test Photoelectric Dye-Coupled Polyethylene Film as Retinal Prosthesis to Induce Light-Evoked Spikes in Isolated Retinal Dystrophic Tissue of rd1 Mice. Reviewed

    Matsuo T, Terada K, Sakurai M, Liu S, Yamashita K, Uchida T

    Clinics in Surgery   5 ( 2903 )   1 - 9   2020.8

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    File: cis-v5-id2903final20200905.pdf

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  • Interview オール岡山の技術が光を取り戻す!-いよいよ最終段階に来た人工網膜とは Invited

    松尾俊彦, 内田哲也

    Optronics   463   124 - 129   2020.7

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  • 涙腺腫脹でIgG4関連疾患と診断された6例の血清IgG4値による長期経過観察

    松尾 俊彦, 田中 健大, 佐藤 康晴, 片岡 仁美, 宇賀 麻由, 遠西 大輔, 矢野 朋文

    日本リンパ網内系学会会誌   60   92 - 92   2020.7

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  • The timing for diagnosis of anisometropia in Japanese children with congenital eyelid ptosis. Reviewed

    Toshihiko Matsuo

    5 ( 2842 )   1 - 3   2020.6

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  • Superior conjunctiva-sparing intraocular lens-suturing technique with straight long suture needles advanced from the opposite side. Reviewed

    Toshihiko Matsuo

    Clinics in Surgery   5 ( 2847 )   1 - 5   2020.6

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  • 特集:人工視覚の現状と展望 「色素結合薄膜型の人工網膜OUReP(オーレップ)」 Invited

    松尾俊彦, 内田哲也

    光アライアンス   31 ( 7 )   13 - 18   2020

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  • Are there primary intraocular lymphomas that do not develop into central nervous system lymphomas? Reviewed

    Toshihiko Matsuo, Takehiro Tanaka

    Journal of clinical and experimental hematopathology : JCEH   59 ( 4 )   168 - 174   2019.12

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    Primary intraocular lymphomas frequently develop into central nervous system lymphomas and vice versa. This study reviewed 22 consecutive patients with primary intraocular lymphoma diagnosed by immunostaining of vitrectomy cell blocks, and examined whether they developed central nervous system lymphoma. Seventeen patients developed central nervous system lymphoma: 3 patients developed intraocular and central nervous system lymphoma simultaneously, 9 patients developed central nervous system lymphoma 1 month to 5 years (median, 3 months) after intraocular lymphoma, and 5 patients developed central nervous system lymphoma preceding the diagnosis of intraocular lymphoma by 3 months to 9 years and 8 months (median, 1.5 years). In contrast, 5 patients did not develop central nervous system lymphoma: 2 patients did not develop local recurrence or central nervous system lymphoma in the follow-up period of 5 years and 11 years, respectively, after vitrectomy alone without additional local or systemic treatment. The remaining 3 patients with intraocular lymphoma had insufficient follow-up periods to determine the prognosis. The results of CD5 immunostaining of vitrectomy specimens were found in pathology reports of 8 patients: 3 patients with CD5-positive large cells and 4 patients with CD5-negative large cells developed central nervous system lymphoma. In summary, only a small number of patients did not develop central nervous system lymphoma based on long-term follow-up after vitrectomy alone. CD5 was not a marker of central nervous system involvement in this study population.

    File: JCEH2019final intraocular lymphma.pdf

    DOI: 10.3960/jslrt.19019

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  • Lacrimal Sac Malignant Melanoma in 15 Japanese Patients: Case Report and Literature Review. Reviewed

    Matsuo T, Tanaka T, Yamasaki O

    Journal of investigative medicine high impact case reports   7   2324709619888052   2019.1

  • Vision evaluation by functional observational battery, operant behavior test, and light/dark box test in retinal dystrophic RCS rats versus normal rats Reviewed

    Toshihiko Matsuo, Tetsuya Uchida, Koichiro Yamashita, Shigiko Takei, Daisuke Ido, Atsushi Fujiwara, Masahiko Iino, Masao Oguchi

    HELIYON   5 ( e01936 )   2019

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    File: Heliyon2019 RCSrat.pdf

    DOI: 10.1016/j.heliyon.2019.e01936

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  • Photoelectric Dye-Coupled Polyethylene Film: Photoresponsive Properties Evaluated by Kelvin Probe and In Vitro Biological Response Detected in Dystrophic Retinal Tissue of Rats Reviewed

    Toshihiko Matsuo, Mikako Sakurai, Keiko Terada, Tetsuya Uchida, Koichiro Yamashita, Tenu Tanaka, Kenichi Takarabe

    ADVANCED BIOMEDICAL ENGINEERING   8   137 - 144   2019

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    File: ABE2019 OUReP.pdf

    DOI: 10.14326/abe.8.137

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  • Long-term outcome in 7 patients with idiopathic orbital myositis. Reviewed

    Matsuo T

    Japanese Clinical Medicine   10   1 - 5   2019

  • Intraocular lymphoma as relapse after chemotherapy for primary breast diffuse large B-cell lymphoma.

    Toshihiko Matsuo, Takehiro Tanaka, Tomofumi Yano

    Journal of clinical and experimental hematopathology : JCEH   58 ( 4 )   180 - 183   2018.12

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    DOI: 10.3960/jslrt.18026

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  • Visual Evoked Potential Recovery by Subretinal Implantation of Photoelectric Dye-Coupled Thin Film Retinal Prosthesis in Monkey Eyes With Macular Degeneration. Reviewed

    Matsuo T, Uchida T, Sakurai J, Yamashita K, Matsuo C, Araki T, Yamashita Y, Kamikawa K

    Artificial organs   42 ( 8 )   E186 - E203   2018.8

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    File: final version Matsuo_et_al-2018-Artificial_Organs.pdf

    DOI: 10.1111/aor.13120

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  • Visual evoked potential in rabbits’ eyes with subretinal implantation by vitrectomy of Okayama university-type retinal prosthesis (OURePTM) Reviewed

    Toshihiko Matsuo, Tetsuya Uchida, Koichiro Yamashita, Shigiko Takei, Daisuke Ido, Mamoru Tanaka, Masao Oguchi, Toshinori Furukawa

    Journal of Veterinary Medical Science   80 ( 2 )   247 - 259   2018.2

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  • MGST2 and WNT2 are candidate genes for comitant strabismus susceptibility in Japanese patients Reviewed

    Jingjing Zhang, Toshihiko Matsuo

    PEERJ   5 ( e3935 )   e3935   2017.10

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  • Visual evoked potential in RCS rats with Okayama University-type retinal prosthesis (OUReP (TM)) implantation Reviewed

    Alamusi, Toshihiko Matsuo, Osamu Hosoya, Tetsuya Uchida

    JOURNAL OF ARTIFICIAL ORGANS   20 ( 2 )   158 - 165   2017.6

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  • Vogt-Koyanagi-Harada disease-like posterior uveitis in the course of nivolumab (anti-PD-1 antibody), interposed by vemurafenib (BRAF inhibitor), for metastatic cutaneous malignant melanoma. Reviewed

    Matsuo T, Yamasaki O

    Clinical case reports   5 ( 5 )   694 - 700   2017.5

  • 眼窩涙腺部腫瘍生検で木村病と確定した後にネフローゼ症候群を発症した1例

    松尾 俊彦, 田中 健大, 木野村 賢

    日本リンパ網内系学会会誌   57   109 - 109   2017.5

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  • Photoelectric Dye Used for Okayama University-Type Retinal Prosthesis Reduces the Apoptosis of Photoreceptor Cells Reviewed

    Shihui Liu, Toshihiko Matsuo, Osamu Hosoya, Tetsuya Uchida

    JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS   33 ( 3 )   149 - 160   2017.4

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  • Positive bacterial culture in conjunctival sac before cataract surgery with night stay is related to diabetes mellitus Reviewed

    Tetsuhiro Kawata, Toshihiko Matsuo

    BMC OPHTHALMOLOGY   17 ( 1 )   14   2017.2

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  • Nephrotic syndrome during the tapering of oral steroids after pathological diagnosis of Kimura disease from a lacrimal gland mass: case report and review of 10 Japanese patients. Reviewed

    Matsuo T, Tanaka T, Kinomura M

    Journal of clinical and experimental hematopathology : JCEH   57 ( 3 )   147 - 152   2017

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    A 42-year-old man with eosinophilia and high serum immunoglobulin E (IgE) developed a lacrimal gland mass on the left side. Excisional biopsy revealed hyperplasia of lymphoid follicles, and infiltration with lymphocytes and eosinophils around lacrimal gland acini, leading to the pathological diagnosis of Kimura disease. IgE-positive cells were mainly found along follicular dendritic cells, and a small number of IgG4-positive cells was present. One month after oral prednisolone was started at 40 mg daily and tapered to 10 mg daily, he developed lower leg edema on both sides and marked proteinuria (10.8 g/day). Renal biopsy showed no glomerular abnormalities, no immunoglobulin deposition, and no tubulointerstitial infiltration with eosinophils, leading to the diagnosis of minimal change nephrotic syndrome. Proteinuria subsided in response to an increased dose of prednisolone to 30 mg daily. Proteinuria relapsed three times in the following 5 years when oral prednisolone was tapered. In conclusion, Kimura disease manifested as an orbital mass and did not relapse. However, nephrotic syndrome relapsed frequently with background eosinophilia and high serum IgE. This study reviewed the clinical features of 10 Japanese patients with Kimura disease associated with proteinuria.

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  • Subretinal implantation of Okayama university-type retinal prosthesis (OURepTM) in canine eyes by vitrectomy Reviewed

    Toshihiko Matsuo, Tetsuya Uchida, Makoto Nitta, Koichiro Yamashita, Shigiko Takei, Daisuke Ido, Mamoru Tanaka, Masao Oguchi, Toshinori Furukawa

    Journal of Veterinary Medical Science   79 ( 12 )   1939 - 1946   2017

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  • Orbital MALT Lymphoma after Autologous Stem Cell Transplantation for Follicular Lymphoma as Relapse of Diffuse Large B-Cell Lymphoma. Reviewed

    Matsuo T, Tanaka T, Fujii N

    Journal of clinical and experimental hematopathology : JCEH   56 ( 3 )   170 - 175   2017

  • Clinical decision upon resection or observation of ocular surface dermoid lesions with the visual axis unaffected in pediatric patients Reviewed

    Toshihiko Matsuo

    SPRINGERPLUS   4 ( 1 )   534   2015.9

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  • Vision maintenance and retinal apoptosis reduction in RCS rats with Okayama University-type retinal prosthesis (OUReP (TM)) implantation Reviewed

    Alamusi, Toshihiko Matsuo, Osamu Hosoya, Kimiko M. Tsutsui, Tetsuya Uchida

    JOURNAL OF ARTIFICIAL ORGANS   18 ( 3 )   264 - 271   2015.9

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  • How far is observation allowed in patients with ectopia lentis? Reviewed

    Toshihiko Matsuo

    SPRINGERPLUS   4   461   2015.8

  • Clinical factors underlying a single surgery or repetitive surgeries to treat superior oblique muscle palsy Reviewed

    Kana Aoba, Toshihiko Matsuo, Ichiro Hamasaki, Kayoko Hasebe

    SPRINGERPLUS   4 ( 166 )   166   2015.4

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  • Intraocular Relapse with Hypopyon and Retinal Infiltrates after Chemotherapy and Peripheral Blood Stem Cell Transplantation for Extranodal NK/T-Cell Lymphoma. Reviewed

    Matsuo T, Tanaka T, Ichimura K, Meguri Y

    Journal of clinical and experimental hematopathology : JCEH   55 ( 3 )   157 - 161   2015

  • Oral infection control to assist infliximab therapy in a Behçet's disease patient with severe eye inflammation in response to dental treatment: a case report. Reviewed International journal

    Kudo C, Wakabayashi H, Shimoe M, Kobayashi H, Ito T, Ohkawa T, Isoshima-Nakamura A, Mineshiba J, Yoshioka N, Nawachi K, Maeda H, Matsuo T, Makino H, Takashiba S

    Clinical case reports   2 ( 6 )   274 - 280   2014.12

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    KEY CLINICAL MESSAGE: We report a case of Behçet's disease which was aggravated by psychological stress and oral infection. The control of oral infection under medical and dental collaboration is important for providing Behçet's disease patients with the optimal medical care and for facilitating the relief of the primary disease.

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  • Infective Endocarditis With Origin in Orbital Vascular Malformation and Maxillary Sinusitis: A Case Report and Review of Four Patients in the Literature Reviewed

    Toshihiko Matsuo, Yoshitaka Iwamoto, Hironori Okamoto, Daisuke Iguchi

    Cureus   16 ( 11 )   e74873   2014.12

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  • Mantle cell lymphoma diagnosed by conjunctival salmon-pink lesion biopsy. Reviewed

    Matsuo T, Ichimura K, Kubonishi S

    Journal of clinical and experimental hematopathology : JCEH   54 ( 2 )   143 - 147   2014

  • 眼底綿花様白斑を合併した全身性エリテマトーデスの1例 眼合併症と疾患活動性との関連性に関する検討

    杉生 真帆, 青山 裕美, 梶田 藍, 竹島 千夏, 濱田 利久, 松尾 俊彦, 赤塚 俊文, 岩月 啓氏

    臨床皮膚科   66 ( 12 )   960 - 964   2012.11

  • MDSをともない、経過中に涙丘と骨髄浸潤をきたした芽球性形質細胞様樹状細胞腫瘍の1例

    濱田 利久, 鈴木 大介, 竹島 千夏, 三宅 智子, 杉生 真帆, 岩月 啓氏, 松尾 俊彦

    Skin Cancer   26 ( 3 )   387 - 387   2012.2

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  • SLEに発症した網膜症(綿花様白斑)と疾患活動性との比較検討

    杉生 真帆, 梶田 藍, 竹島 千夏, 濱田 利久, 青山 裕美, 岩月 啓氏, 松尾 俊彦, 赤塚 俊文

    日本皮膚科学会雑誌   121 ( 11 )   2278 - 2278   2011.10

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  • MDSをともない、経過中に涙丘と骨髄浸潤をきたした芽球性形質細胞様樹状細胞腫瘍の1例

    濱田 利久, 鈴木 大介, 竹島 千夏, 三宅 智子, 杉生 真帆, 松尾 俊彦, 岩月 啓氏

    日本皮膚悪性腫瘍学会学術大会プログラム・抄録集   27回   121 - 121   2011.6

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  • Optical coherence tomographic parameters as objective signs for visual acuity in patients with retinitis pigmentosa, future candidates for retinal prostheses Reviewed

    Miho Tamaki, Toshihiko Matsuo

    Journal of Artificial Organs   14 ( 2 )   140 - 150   2011

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    DOI: 10.1007/s10047-011-0557-9

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  • Erratum: Optical coherence tomographic parameters as objective signs for visual acuity in patients with retinitis pigmentosa, future candidates for retinal prostheses (Journal of Artificial Organs (2011) 14, (140-150) DOI: 10.1007/s10047-011-0557-9) Reviewed

    Miho Tamaki, Toshihiko Matsuo

    Journal of Artificial Organs   14 ( 4 )   385   2011

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    DOI: 10.1007/s10047-011-0597-1

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  • 脈絡膜黒色腫の病期、再発診断におけるFDG-PET/CTの初期経験

    荻野 裕香, 奥村 能啓, 佐藤 修平, 新家 崇義, 原田 聡介, 檜垣 文代, 宗田 由子, 山本 岳玄, 加藤 勝也, 郷原 英夫, 平木 隆夫, 三村 秀文, 加地 充昌, 松尾 俊彦, 金澤 右

    日本医学放射線学会秋季臨床大会抄録集   46回   S530 - S530   2010.8

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  • Immunoglobulin G4 (IgG4)-positive or -negative ocular adnexal benign lymphoid lesions in relation to systemic involvement. Reviewed

    Matsuo T, Ichimura K, Sato Y, Tanimoto Y, Kiura K, Kanazawa S, Okada T, Yoshino T

    Journal of clinical and experimental hematopathology : JCEH   50 ( 2 )   129 - 142   2010

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    The purpose of this study is to determine the relationship of ocular adnexal benign or reactive lymphoid hyperplasia, including orbital pseudotumor, with immunoglobulin G4 (IgG4)-related diseases. Medical charts of 9 consecutive patients with ocular adnexal benign lymphoid lesions, seen in the Department of Ophthalmology, Okayama University Hospital, were reviewed, and pathological sections were restained immunohistochemically for IgG4-, IgG-, and CD138-positive plasma cells. The diagnosis of IgG4-positive lesions was based on 10 or more IgG4-positive plasma cells in a high-power field and greater than 40% ratios of IgG4-positive plasma cells/CD138-positive plasma cells and IgG4-positive plasma cells/IgG-positive plasma cells. IgG4-positive lesions were determined as absent in 5 patients (4 with bilateral lacrimal/orbital lesions and one with a unilateral conjunctival lesion), none of whom showed systemic manifestations. In contrast, IgG4-positive lesions were present in 4 patients (3 with bilateral lacrimal/orbital lesions and one with a unilateral lacrimal/orbital lesion), who showed systemic manifestations : one with Hashimoto thyroiditis, one with IgG4-positive bilateral interstitial lung disease and hepatic inflammatory pseudotumor, one with bilateral interstitial lung disease, and one with systemic lymphadenopathy and antiphospholipid syndrome. In conclusion, IgG4-positive ocular adnexal benign lymphoid lesions might be used as a benchmark for the probable presence of other systemic lymphoid lesions.

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  • A case of aplasia of inferior rectus muscle

    Tomoko Watanabe, Toshihiko Matsuo, Takashi Furuse, Satoshi Hasebe, Toshihiro Yanagawa, Toshinari Shimizu, Hiroshi Ohtsuki

    Japanese Journal of Clinical Ophthalmology   62 ( 8 )   1309 - 1314   2008.8

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  • Different histopathological types of orbital lymphoma 16 years after systemic follicular lymphoma: immunohistochemical and immunogenetic analyses of two cases. Reviewed

    Matsuo T, Ichimura K, Shinagawa K, Yoshino T

    Journal of clinical and experimental hematopathology : JCEH   48 ( 1 )   17 - 24   2008.4

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    The purpose of this study is to show that the histopathological type of an orbital lymphoma can differ from the systemic follicular lymphoma that precedes it. A 44-year-old man (Patient #1) and a 50-year-old man (Patient #2) presented with generalized lymphadenopathy due to grade 1 follicular lymphoma proven on lymph node biopsy. Patient #1 was followed without treatment for 16 years when he developed a right orbital mass. Patient #2 underwent several courses of combination chemotherapy as well as radiation but relapsed. The second biopsy of the lymph node nine years later showed the same histopathological type of follicular lymphoma. He developed an orbital mass on the right side 16 years after the initial presentation. In Patient #1, excisional biopsy of the orbital masses showed extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). In Patient #2, biopsy revealed the orbital mass to be T-cell/histiocyte-rich diffuse large B-cell lymphoma. In Patient #1, when comparing the original lymph node biopsy to the orbital biopsy obtained years later, no evidence for clonality was noted by polymerase chain reaction. In Patient #2, the amplification by polymerase chain reaction of the immunoglobulin heavy chain gene rearrangement in the lymph node lesion and the orbital lesion gave rise to a single discrete band with the same DNA sequence except for five nucleotide changes, indicating the same clonality in the presence of genomic changes. In conclusion, orbital lymphomas can occur as a second lymphoma with a different histopathological type in the long-term follow-up of systemic lymphomas. The original and subsequent lymphomatous lesions may or may not share neoplastic cell clonality and all genomics. [J Clin Exp Hematopathol 48(1) : 17-24, 2008]

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  • Clinical features, ARIX and PHOX2B nucleotide changes in three families with congenital superior oblique muscle palsy Reviewed

    Sayuri Imai, Toshihiko Matsuo, Emi Itoshima, Hiroshi Ohtsuki

    ACTA MEDICA OKAYAMA   62 ( 1 )   45 - 53   2008.2

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  • [Vision engineering--photoelectric dye-based retinal prostheses: Okayama University model]. Reviewed

    Matsuo T

    Brain and nerve = Shinkei kenkyu no shinpo   59 ( 4 )   331 - 338   2007.4

  • Vision engineering - Photoelectric dye-based retinal prostheses: Okayama university model Reviewed

    Toshihiko Matsuo

    Brain and Nerve   59 ( 4 )   331 - 338   2007.4

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  • A low-vision-care viewpoint of cataract surgery for patients with retinitis pigmentosa

    Noriko Morimoto, Toshihiko Matsuo, Hiroshi Ohtsuki

    Folia Ophthalmologica Japonica   58 ( 3 )   153 - 157   2007.3

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  • Detection of strabismus and amblyopia in 1.5-and 3-year-old children by a preschool vision-screening program in Japan Reviewed

    Toshihiko Matsuo, Chie Matsuo, Hiroaki Matsuoka, Keiko Kio

    ACTA MEDICA OKAYAMA   61 ( 1 )   9 - 16   2007.2

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  • Prostaglandins F-2 alpha and E-2 in aqueous humor of patients with cataract surgery Reviewed

    T Matsuo

    JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS   20 ( 2 )   101 - 106   2004.4

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    DOI: 10.1089/108076804773710768

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  • ARIX gene polymorphisms in patients with congenital superior oblique muscle palsy Reviewed

    Y Jiang, T Matsuo, H Fujiwara, S Hasebe, H Ohtsuki, T Yasuda

    BRITISH JOURNAL OF OPHTHALMOLOGY   88 ( 2 )   263 - 267   2004.2

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    DOI: 10.1136/bjo2003.021527

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  • A Simple Method for Screening Photoelectric Dyes towards Their Use for Retinal Prostheses Reviewed

    Toshihiko Matsuo

    Acta Medica Okayama   57 ( 5 )   257 - 260   2003.10

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  • Clinical correlations of aggrecan in the resected medial rectus muscle of patients with intermittent exotropia Reviewed

    T Yamane, T Matsuo, S Hasebe, H Ohtsuki

    ACTA MEDICA OKAYAMA   57 ( 4 )   199 - 204   2003.8

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  • Genome-wide search for strabismus susceptibility loci Reviewed

    H Fujiwara, T Matsuo, M Sato, T Yamane, M Kitada, S Hasebe, H Ohtsuki

    ACTA MEDICA OKAYAMA   57 ( 3 )   109 - 116   2003.6

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  • Multiple sclerosis-like disease secondary to alpha interferon Reviewed

    T Matsuo, R Takabatake

    OCULAR IMMUNOLOGY AND INFLAMMATION   10 ( 4 )   299 - 304   2002.12

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  • Seropositivity of human herpesvirus-8 in patients with uveitis Reviewed

    T Matsuo, M Itami

    OCULAR IMMUNOLOGY AND INFLAMMATION   10 ( 3 )   197 - 199   2002.9

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  • Submacular exudates with serous retinal detachment caused by cat scratch disease Reviewed

    T Matsuo, M Kato

    OCULAR IMMUNOLOGY AND INFLAMMATION   10 ( 2 )   147 - 150   2002.6

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    DOI: 10.1076/ocii.10.2.147.13979

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  • The incidence and pathology of conjunctival ulceration in Behcet's syndrome Reviewed

    T Matsuo, M Itami, H Nakagawa, M Nagayama

    BRITISH JOURNAL OF OPHTHALMOLOGY   86 ( 2 )   140 - 143   2002.2

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  • Two cases of ocular injury due to air-bag activation

    F. Nonaka, M. Nagayama, T. Matsuo, F. Shiraga, H. Ohtsuki

    Japanese Journal of Clinical Ophthalmology   55 ( 2 )   158 - 162   2001

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  • A novel gene (retinovin) expressed selectively in the early stage of chick retinal development Reviewed

    M Itami, T Matsuo, H Ohtsuki

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   276 ( 1 )   12 - 15   2000.9

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  • Identification of ingrowth site of idiopathic subfoveal choroidal neovascularization by indocyanine green angiography Reviewed

    Fumio Shiraga, Chieko Shiragami, Toshihiko Matsuo, Shiho Yokoe, Ippei Takasu, Hiroshi Ohtsuki

    Ophthalmology   107 ( 3 )   600 - 607   2000.3

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    DOI: 10.1016/S0161-6420(99)00126-8

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  • Risk for ocular attacks following phacoemulsification and intraocular lens implantation in patients of Behcet disease

    M. Takahashi, T. Matsuo, A. Yamaoka, H. Kuwada, H. Ohtsuki, Y. Inoue, K. Egi

    Japanese Journal of Clinical Ophthalmology   54 ( 8 )   1499 - 1502   2000

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  • Surgical treatment of submacular hemorrhage associated with idiopathic polypoidal choroidal vasculopathy Reviewed

    Fumio Shiraga, Toshihiko Matsuo, Shiho Yokoe, Ippei Takasu, Toshio Okanouchi, Hiroshi Ohtsuki, Hans E. Grossniklaus

    American Journal of Ophthalmology   128 ( 2 )   147 - 154   1999.8

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    DOI: 10.1016/S0002-9394(99)00078-1

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  • A novel gene (oculomedin) induced by mechanical stretching in human trabecular cells of the eye Reviewed

    Yukiko Sato, Toshihiko Matsuo, Hiroshi Ohtsuki

    Biochemical and Biophysical Research Communications   259 ( 2 )   349 - 351   1999.6

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    DOI: 10.1006/bbrc.1999.0797

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  • Choroidal abnormalities in Behçet disease observed by simultaneous indocyanine green and fluorescein angiography with scanning laser ophthalmoscopy. Reviewed International journal

    T Matsuo, Y Sato, F Shiraga, C Shiragami, Y Tsuchida

    Ophthalmology   106 ( 2 )   295 - 300   1999.2

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    OBJECTIVE: To examine choroidopathy in patients with Behçet disease. DESIGN: Prospective clinical study. PARTICIPANTS: Thirty-three patients (63 eyes) with Behçet disease. INTERVENTION: Patients underwent simultaneous indocyanine green (ICG) and fluorescein angiography with a double detector of scanning laser ophthalmoscopy. MAIN OUTCOME MEASURES: Angiographic findings recorded on videotapes were evaluated. The relation of angiographic findings with systemic activity and aqueous inflammation was also analyzed. RESULTS: Fluorescein angiography showed leakage in varying degrees from retinal vessels in 30 patients (53 eyes, 84%). The ICG angiographic findings were choroidal vascular wall staining in 16 eyes (25%), hyperfluorescent spots in 42 eyes (66%) and hypofluorescent plaques in 22 eyes (35%), both of which were not evident with fluorescein, leakage from choroidal vessels in 3 eyes (5%), and irregular filling of choriocapillaris in 11 eyes (17%). These findings did not have a statistically significant correlation with the presence or absence of aqueous inflammation or oral aphthous ulcerations. CONCLUSIONS: The patients with Behçet disease showed choroidal abnormalities, which could be revealed only by ICG angiography, but not with funduscopy or fluorescein angiography. Simultaneous ICG and fluorescein angiography would be useful for examining choroidal lesions in Behçet disease.

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  • Choroidal lesions in sarcoidosis evaluated by indocyanine green angiography

    M. Itami, T. Matsuo, C. Shiragami, F. Shiraga, Y. Sato, H. Ohtsuki

    Japanese Journal of Clinical Ophthalmology   53 ( 4 )   641 - 644   1999

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  • Transplanted and repopulated retinal pigment epithelial cells on damaged Bruch's membrane in rabbits. International journal

    C Shiragami, T Matsuo, F Shiraga, N Matsuo

    The British journal of ophthalmology   82 ( 9 )   1056 - 62   1998.9

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    AIMS: The authors studied how artificially damaged Bruch's membrane influenced growth and differentiation of transplanted embryonic retinal pigment epithelial (RPE) cells and of host RPE cells in rabbits. METHODS: Embryonic RPE cells obtained from pigmented rabbits were transplanted into the subretinal space of adult albino rabbits. The host RPE was removed with a silicone cannula, and Bruch's membrane was damaged by scratching with a microhooked 27 gauge needle under the detached retina in closed vitrectomy. The transplantation sites were examined 3, 7, and 14 days after surgery by light and electron microscopy. RESULTS: Varying degrees of damage in Bruch's membrane were observed. Pigmented and hypopigmented RPE cells showed a normal polarity and tight junctions were seen at the sites of mild to moderate damage 3-7 days after the surgery. In contrast, fibroblast-like cells with no such features of RPE cells formed multiple layers at the sites of severe damage involving the full thickness of Bruch's membrane and the choriocapillaris even 14 days after the surgery. Without transplantation, host RPE cells repopulated the damaged areas in the same way as transplanted RPE cells. CONCLUSIONS: Transplanted embryonic RPE cells as well as host RPE cells grew and differentiated on the moderately damaged Bruch's membrane, while the severely damaged Bruch's membrane did not allow differentiation of RPE cells although these cells could grow and cover the damaged areas.

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  • Bovine trabecular cells produce TIMP-1 and MMP-2 in response to mechanical stretching Reviewed

    Y Okada, T Matsuo, H Ohtsuki

    JAPANESE JOURNAL OF OPHTHALMOLOGY   42 ( 2 )   90 - 94   1998.3

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  • Aqueous vascular endothelial growth factor increases in anterior segment ischemia in rabbits Reviewed

    T Tanaka, T Matsuo, H Ohtsuki

    JAPANESE JOURNAL OF OPHTHALMOLOGY   42 ( 2 )   85 - 89   1998.3

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  • Geographic choroiditis and retinal vasculitis in rheumatoid arthritis Reviewed

    Toshihiko Matsuo, Ikuya Masuda, Nobuhiko Matsuo

    Japanese Journal of Ophthalmology   42 ( 1 )   51 - 55   1998.1

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    DOI: 10.1016/S0021-5155(97)00102-0

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  • Metastasis to the iris in squamous cell lung cancer Reviewed

    Akio Hiraki, Hiroshi Ueoka, Toshihiko Matsuo, Tomio Nakagawa, Tadashi Yoshino, Katsuyuki Kiura, Masahiro Tabata, Katsuyoshi Sakae, Yuji Ohtsuki, Yoshio Hiraki, Mine Harada

    International Journal of Clinical Oncology   3 ( 3 )   186 - 190   1998

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    DOI: 10.1007/BF02489914

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  • A case of atypical Treacher-Collins syndrome

    Hirotake Fujiwara, Michio Sugihara, Toshihiko Matsuo, Miki Nouso, Satoshi Hasebe, Hiroshi Ohtsuki

    Folia Ophthalmologica Japonica   48 ( 9 )   1154 - 1157   1997.9

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  • Bilateral iridocyclitis with retinal capillaritis in juveniles Reviewed

    T. Matsuo, N. Matsuo

    Ophthalmology   104 ( 6 )   939 - 944   1997

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    DOI: 10.1016/S0161-6420(97)30203-6

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  • Abducens nerve palsy in a case under treatment with systemic interferon

    M. Hosogi, S. Hasebe, T. Matsuo, H. Ohtsuki

    Japanese Journal of Clinical Ophthalmology   51 ( 7 )   1357 - 1360   1997

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  • Insufficiency of accommodation and convergence in whiplash injuries

    Y. Tsutsui, T. Matsuo, K. Hasebe, H. Ohtsuki, N. Matsuo

    Japanese Journal of Clinical Ophthalmology   49 ( 4 )   775 - 778   1995

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  • ANOMALOUS POSTERIOR INSERTION OF MEDIAL RECTUS MUSCLE SIMULATING CONGENITAL OCULOMOTOR PALSY Reviewed

    M OKANO, T MATSUO, H KONISHI, S HASEBE, Y TADOKORO, H OHTSUKI

    JAPANESE JOURNAL OF OPHTHALMOLOGY   34 ( 3 )   275 - 279   1990

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  • Familial hypo-retinol-binding proteinemia found in a child with keratomalacia Reviewed

    T. Matsuo, N. Matsuo, F. Shiraga, N. Koide

    Journal of Japanese Ophthalmological Society   92 ( 4 )   694 - 698   1988

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  • Mild type acute retinal necrosis syndrome involving both eyes at three-year interval Reviewed

    T. Matsuo, T. Nakayama, T. Koyama, N. Matsuo

    Japanese Journal of Ophthalmology   31 ( 3 )   455 - 460   1987

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Books

  • 「今日の眼疾患治療指針 第4版」 第16章 眼窩疾患 横紋筋肉腫 平滑筋肉腫 骨腫 神経線維腫,神経線維腫症

    松尾俊彦( Role: Joint author)

    医学書院  2022.9 

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  • 「交感性眼炎」 眼科疾患最新の治療2022-2024

    松尾俊彦( Role: Joint author)

    南江堂  2022 

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  • 「2-12. 人工網膜」 テクノロジー・ロードマップ2021-2030 医療・健康・食農編

    松尾俊彦, 内田哲也( Role: Joint author)

    日経BP  2021 

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  • 眼科学 第3版 網膜.網膜の正常構造と機能. 1)網膜の構造

    松尾俊彦( Role: Joint author)

    文光堂  2020 

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  • 「2-8. 人工網膜」 テクノロジー・ロードマップ2019-2028 医療・健康・食農編

    松尾俊彦, 内田哲也, 蔵本孝一( Role: Joint author)

    日経BP  2019 

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  • 「脈絡膜血管腫」 眼科疾患 最新の治療2019-2021

    松尾俊彦( Role: Joint author)

    南江堂  2019 

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  • "Candidate genes for strabismus susceptibility chromosomal loci" Advances in Strabismus, Proceedings of the XIIth Meeting of the International Strabismological Association in Kyoto, Japan, December 1-4, 2014

    Rotatip Publisher, Ankara, Turkey  2016 

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  • サルコイドーシス 「眼科疾患 最新の治療2016-2018」

    南江堂  2016 

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  • 今日の眼疾患治療指針 第3版「横紋筋肉腫,平滑筋肉腫,骨腫,神経線維腫・神経線維腫症」

    医学書院  2016 

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  • 「斜視の病因論について教えてください」 弱視・斜視診療のスタンダード 眼科診療クオリファイ22

    中山書店  2014 

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  • 「眼窩蜂巣炎」 眼救急疾患スクランブル 専門医のための眼科診療クオリファイ21

    中山書店  2014 

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  • 「涙腺腫瘍」 眼科疾患最新の治療2013-2015

    南江堂  2013 

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  • 眼科学第2版 「脈絡膜の正常構造と機能」「網膜の正常構造と機能」

    文光堂  2011 

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  • Ocular Infection Navigator 【猫ひっかき病」

    千寿製薬  2010 

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  • 改訂第5版 新遺伝子工学ハンドブック 「suppression subtractive hybridization」

    羊土社  2010 

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  • 糖尿病透析患者診療・ケアハンドブック 「糖尿病性眼合併症」

    南江堂  2009 

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  • 眼科診療のコツと落とし穴2 手術―

    中山書店,東京  2008 

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  • 眼科診療のコツと落とし穴4 薬物療法

    中山書店,東京  2008 

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  • 眼科インストラクションコース17 眼科診療のスキルアップ 緑内障編

    メジカルビュー社,東京  2008 

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  • 今日の眼疾患治療指針 第2版

    医学書院  2007 

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  • 2007 今日の治療指針 私はこう治療している

    医学書院  2007 

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  • 眼科プラクティス16 眼内炎症診療のこれから

    文光堂  2007 

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  • 基礎からわかるぶどう膜炎

    金原出版,東京  2006 

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  • 眼科プラクティス12 眼底アトラス

    文光堂  2006 

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  • 眼科プラクティス6 眼科臨床に必要な解剖生理 Ⅵ.網膜・脈絡膜 7.網膜色素上皮の機能

    文光堂,東京  2005 

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  • 眼科プラクティス8 いますぐ役立つ眼病理 ・前房水細胞診 化膿性vs腫瘍性vs肉芽腫性 ・前房水細胞診の手順 ・硝子体細胞診の手順

    文光堂,東京  2005 

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  • 眼科診療ガイド

    文光堂,東京  2004 

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  • 眼科当直医・救急ガイド

    文光堂,東京  2004 

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  • 新 遺伝子工学ハンドブック・改訂第4版

    羊土社,東京  2003 

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  • Progress in Strabismology

    Swelts & Zeitlinger,Lisse  2003 

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  • 眼科診療プラクティス90 眼窩疾患の診療

    文光堂,東京  2003 

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  • 眼の事典

    朝倉書店,東京  2003 

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  • 眼科診療Q&A

    六法出版,東京  2002 

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  • 眼科診療プラクティス85 血管閉塞性疾患の診療

    文光堂,東京  2002 

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  • 第5回トレハロースシンポジウム記録集

    東京  2002 

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  • 眼科学

    文光堂,東京  2002 

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  • 眼科診療プラクティス68 所見から診るぶどう膜炎

    文光堂  2001 

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  • 眼科診療プラクティス75 眼科レーザー治療のすべて

    文光堂  2001 

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MISC

  • 結膜リンパ腫 長期の経過あきらかに 追加治療は必要か 経過観察か放射線を

    松尾俊彦

    十勝毎日新聞   22面   2024.10

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    File: 結膜リンパ腫_十勝毎日新聞20241028.pdf

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  • 結膜リンパ腫 長期の経過が明らかに 追加治療は必要か

    松尾俊彦

    八重山毎日新聞   7面   2024.10

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    File: 結膜リンパ腫_八重山毎日新聞20241018.pdf

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  • 有機色素分子を部材とする世界初の医療機器「光電変換色素薄膜型人工網膜(OUReP)」 Invited

    松尾俊彦, 石金浩史, 内田哲也

    眼薬理   37 ( 1 )   38 - 47   2023.9

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    File: OUReP 眼薬理37 38-47,2023.pdf

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  • mRNAの制御機構の解明と治療薬・ワクチンへの応用「網羅的発現解析(RNA-seq)とタンパク質の因果性」 Invited Reviewed

    宮地まり, 松尾俊彦

    mRNAの制御機構の解明と治療薬・ワクチンへの応用 (株)技術情報協会   201 - 211   2023.2

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    Authorship:Corresponding author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    File: mRNAの制御機構の解明と治療薬・ワクチンへの活用 宮地・松尾.pdf

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  • 「みんなの健康Library 」身近で意外? 新しい医療のカタチ「再び光の世界へ 視力を取り戻す「人工網膜」

    松尾俊彦

    みんなの健康Library、保健同人社   2021 ( 11 )   1 - 3   2021.11

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    File: 保健同人社new-medical20211101 OUReP.pdf

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  • 科学新聞 第3837号2021年8月6日「光電変換色素薄膜型人工網膜 神経伝導メカニズム解明 岡山大と加トロント大が共同」

    内田哲也, 山下功一郎, 松尾俊彦

    科学新聞 第3837号2021年8月6日   2021.8

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    File: 科学新聞第3837号20210806.jpg

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  • 人生100年時代を支えるミライの医療技術100「 32 色素結合薄膜型人工網膜: 失われた視覚を人工網膜で取り戻す]

    日経メディカル 2021年4月号   ( 641 )   52 - 52   2021.4

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  • A new knock-out mouse model (MGST2 gene knock-out) of strabismus

    Chaomulige Chaomulige, Toshihiko Matsuo, Shihui Liu, Mari Miyaji, Osamu Hosoya, Hatada Izuho, Horii Takuro

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   61 ( 7 )   2020.6

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  • 陽子線治療後に免疫チェックポイント阻害薬を投与した悪性黒色腫の3例

    加持 達弥, 山崎 修, 森実 真, 松尾 俊彦, 田端 雅弘, 勝井 邦彰, 脇 隆博

    日本皮膚科学会雑誌   129 ( 5 )   1177 - 1177   2019.5

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  • 中枢神経系リンパ腫を発症しない眼内リンパ腫はあるか?

    松尾 俊彦, 田中 健大

    日本リンパ網内系学会会誌   59   125 - 125   2019.5

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  • 乳腺リンパ腫(DLBCL)治療後に眼内リンパ腫として再発した1例

    松尾 俊彦, 田中 健大, 矢野 朋文

    日本リンパ網内系学会会誌   58   115 - 115   2018.5

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  • Okayama Univ. e-Bulletin OU-MRU 2018.06 Vol.53 Okayama University Research: Successful implantation and testing of retinal prosthesis in monkey eyes with retinal degeneration

    Okayama University Medical Research Updates (OU-MRU) Vol. 53   53   1 - 3   2018

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  • Novel disposable injector (OUReP Injector) tested in rabbits’ eyes for subretinal implantation of Okayama University-type retinal prosthesis (OUReP). Reviewed

    Matsuo T, Uchida T, Yamashita K, Matsuo C, Kawakami Y, Hitomi T, Taga K, Sanada T, Yamashita Y, Kuramoto K

    Animal Eye Research   37   1 - 12   2018

  • Okayama Univ. e-Bulletin OU-MRU 2018.01 Vol.47 Okayama University Research: Candidate genes for eye misalignment identified

    Okayama University Medical Research Updates (OU-MRU) Vol. 47   47   1 - 3   2018

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  • 岡山県医用工学研究会25周年記念誌「岡山県ものづくり中小企業と連携して進める岡山大学方式人工網膜(OUReP)」

    松尾俊彦

    岡山県医用工学研究会25周年記念誌   38 - 39   2017

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  • Orbital MALT lymphoma after autologous stem cell transplantation for follicular lymphoma as relapse of diffuse large B-cell lymphoma.

    Toshihiko Matsuo, Takehiro Tanaka, Nobuharu Fujii

    Journal of Clinical and Experimental Hematopathology   56 ( 3 )   170 - 175   2017

  • 日本医師会ドクタラーゼ大学紹介:岡山大学 Research 「これからの医療を目指して」

    松尾俊彦

    日本医師会発行 ドクタラーゼ 医学生がこれからの医療を考えるための情報誌   20   36 - 36   2017

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  • 特集「高機能フィルム・シートと製造技術 」ポリエチレンフィルムを利用した人工網膜の実用化に向けて<色素固定薄膜型人工網膜(OURePTM)の実用化に向けた医工連携研究>

    内田哲也, 松尾俊彦

    プラスチックス 2017年3月号   68 ( 3 )   29 - 34   2017

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  • プラスチックス2017年3月号特集「高機能フィルム・シートと製造技術」「ポリエチレンフィルムを利用した人工網膜の実用化に向けて<色素固定薄膜型人工網膜(OUReP)の実用化に向けた医工連携研究>」

    内田哲也, 松尾俊彦

    プラスチックス2017年3月号   ( 3 )   2017

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  • Okayama Univ. e-Bulletin OU-MRU 2017.04 Vol.39 Okayama University Research: Successful test of retinal prosthesis implanted in rats

    Okayama University Medical Research Updates (OU-MRU) Vol. 39   39   1 - 3   2017

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  • 抗PD-1抗体治療後BRAF阻害療法中の進行期メラノーマ患者に生じた原田病 抗PD-1投与前後の免疫応答を含めて

    岩月 啓氏, 山崎 修, 加持 達弥, 濱田 利久, 森実 真, 立川 聖子, 松尾 俊彦, 栄川 伸吾, 鵜殿 平一郎

    西日本皮膚科   78 ( 5 )   554 - 554   2016.10

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  • Apoptosis reduction by a photoelectric dye used for Okayama University-type retinal prosthesis (OUReP (TM))

    Shihui Liu, Toshihiko Matsuo, Osamu Hosoya, Tetsuya Uchida

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   57 ( 12 )   2016.9

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  • Tadao Nakago, 1933-2016 IN MEMORIAM

    Toshihiko Matsuo, Chie Nakago-Matsuo

    AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS   149 ( 5 )   771 - 772   2016.5

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  • American Journal of Orthodontics and Dentofacial Orthopedics"In Memorium, Tadao Nakago, 1933-2016"

    Toshihiko Matsuo, Chie Nakago-Matsuo

    American Journal of Orthodontics and Dentofacial Orthopedics   149 ( 5 )   771 - 772   2016

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  • いちょう並木 岡山大学広報誌 2016年6月 No.81 岡山大学が誇る!注目の最先端研究「医工連携で、新方式の人工網膜を開発 光を失った患者に、新たな”光”を届ける」

    松尾俊彦, 内田哲也

    いちょう並木   81   5 - 6   2016

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  • 岡山医学会雑誌「色素結合薄膜型(岡山大学方式)の人工網膜(OUReP)の医師主導治験」

    松尾俊彦, 内田哲也

    岡山医学会雑誌   127 ( 3 )   223 - 229   2015

  • Intraocular relapse with hypopyon and retinal infiltrates after chemotherapy and peripheral blood stem cell transplantation for extranodal NK/T-cell lymphoma.

    Toshihiko Matsuo, Takehiro Tanaka, Kouichi Ichimura, Yusuke Meguri

    Journal of Clinical and Experimental Hematopathology   55 ( 3 )   157 - 161   2015

  • 人工臓器「第52回日本人工臓器学会大会 論文賞(広領域)受賞レポート」

    阿拉木斯, 松尾俊彦, 細谷修, 筒井公子, 内田哲也

    人工臓器   44 ( 1 )   16 - 17   2015

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  • Okayama University Medical Research Updates (OU-MRU) Vol. 7 "Researchers at Okayama demonstrate the promise of a new approach for stimulating neurons in the eyes of patients with dead photoreceptor cells."

    Toshihiko Matsuo, Tetsuya Uchida

    Okayama University Medical Research Updates (OU-MRU) Vol. 7   7   2015

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  • 両備てい園記念財団「色素結合薄膜型の人工網膜(OUReP)の医師主導治験を目指して」

    松尾俊彦, 内田哲也

    生物学に関する試験論叢   30   117 - 123   2015

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  • 文部科学省・厚生労働省 革新的医療技術創出拠点プロジェクト平成26年度成果報告会 岡山大学方式の人工網膜の医師主導治験:生物学的安全性評価・製造・品質管理

    松尾俊彦

    臨床評価 別刷   43 ( Suppl XXXV )   144 - 147   2015

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  • Intraocular lens implantation in unilateral congenital cataract with minimal levels of persistent fetal vasculature in the first 18 months of life

    Toshihiko Matsuo

    SPRINGERPLUS   3   361   2014.7

  • Glass transition temperature of dried lens tissue pretreated with trehalose, maltose, or cyclic tetrasaccharide

    Tetsuhiro Kawata, Toshihiko Matsuo, Tetsuya Uchida

    SPRINGERPLUS   3   317   2014.6

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  • Vision recovery and retinal apoptosis reduction in RCS rats with Okayama University-type retinal prosthesis

    Bai Alamusi, Toshihiko Matsuo, Osamu Hosoya, Kimiko M. Tsutsui, Tetsuya Uchida

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   55 ( 13 )   2014.4

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  • Clinicopathological correlation for the role of fluorodeoxyglucose positron emission tomography computed tomography in detection of choroidal malignant melanoma

    Toshihiko Matsuo, Yuka Ogino, Kouichi Ichimura, Takehiro Tanaka, Mitsumasa Kaji

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   19 ( 2 )   230 - 239   2014.4

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  • 人工臓器「色素結合薄膜型の人工網膜(OUReP)の医師主導治験を目指して」

    松尾俊彦, 内田哲也

    人工臓器   43 ( 3 )   189 - 193   2014

  • Mantle cell lymphoma diagnosed by conjunctival salmon-pink lesion biopsy.

    Toshihiko Matsuo, Kouichi Ichimura, Shiro Kubonishi

    Journal of Clinical and Experimental Hematopathology   54 ( 2 )   143 - 147   2014

  • Correlation between depth perception by three-rods test and stereoacuity by distance randot stereotest

    Toshihiko Matsuo, Ryo Negayama, Hiroyuki Sakata, Kayoko Hasebe

    Strabismus   22 ( 3 )   133 - 137   2014

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  • 眼科「眼付属器リンパ腫に対する治療の現状」

    松尾俊彦

    眼科   56 ( 1 )   33 - 40   2014

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  • 人工臓器「第51回日本人工臓器学会大会 Tominaga Award 2012受賞レポート」

    阿拉木斯, 松尾俊彦, 細谷修, 筒井公子, 内田哲也

    人工臓器   43 ( 1 )   31 - 32   2014

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  • Development of a Retinal Prosthesis by Using Photoelectric Dye-coupled Polyethylene Films (Okayama University-type Retinal Prosthesis)

    34 ( 5 )   41 - 47   2014

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  • Okayama University e-Bulletin "Intellectual Property and Enterprise" Photoelectric dye-coupled thin film as a novel type of retinal prosthesis.

    Toshihiko Matsuo, Tetsuya Uchida

    Okayama University e-Bulletin Vol. 8, 2014   8   2014

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  • Behavior tests and immunohistochemical retinal response analyses in RCS rats with subretinal implantation of Okayama-University-type retinal prosthesis

    Alamusi, Toshihiko Matsuo, Osamu Hosoya, Kimiko M. Tsutsui, Tetsuya Uchida

    JOURNAL OF ARTIFICIAL ORGANS   16 ( 3 )   343 - 351   2013.9

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  • Postural stability changes during large vertical diplopia induced by prism wear in normal subjects

    Toshihiko Matsuo, Hanako Yamasaki, Hirotaka Yasuhara, Kayoko Hasebec

    Acta Medica Okayama   67 ( 3 )   177 - 183   2013

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  • 日本臨床 増刊号 ANCA関連血管炎の眼病変 「血管炎 -基礎と臨床のクロストーク-」

    日本臨床 増刊号1   71   341 - 346   2013

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  • Stereoscopic three-dimensional images of an anatomical dissection of the eyeball and orbit for educational purposes

    Toshihiko Matsuo, Yoshimasa Takeda, Aiji Ohtsuka

    Acta Medica Okayama   67 ( 2 )   87 - 91   2013

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  • Timing of Prophylactic and Early Vitrectomy for First-Presenting or Recurrent Acute Retinal Necrosis Syndrome

    Toshihiko Matsuo

    ACTA MEDICA OKAYAMA   66 ( 6 )   493 - 497   2012.12

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  • Conjunctival Lymphoma Can Be Detected by FDG PET

    Toshihiko Matsuo, Kouichi Ichimura, Takehiro Tanaka, Mitsumasa Kaji

    CLINICAL NUCLEAR MEDICINE   37 ( 5 )   516 - 519   2012.5

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  • Immunocytochemical Diagnosis as Inflammation by Vitrectomy Cell Blocks in Patients with Vitreous Opacity

    Toshihiko Matsuo, Kouichi Ichimura

    OPHTHALMOLOGY   119 ( 4 )   827 - 837   2012.4

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  • Phenotype-phenotype and genotype-phenotype correlations in patients with idiopathic superior oblique muscle palsy

    Sayuri Imai Ohkubo, Toshihiko Matsuo, Kayoko Hasebe, Yoshie Hirai Shira, Emi Itoshima, Hiroshi Ohtsuki

    JOURNAL OF HUMAN GENETICS   57 ( 2 )   122 - 129   2012.2

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  • 血液内科「眼科領域の両側性、再発性、全身多発性悪性リンパ腫の臨床病態と細胞起源」

    血液内科   65 ( 1 )   33 - 43   2012

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  • Orbital MALT Lymphoma, Abdominal Hodgkin lymphoma, and Systemic Diffuse Large B-cell Lymphoma Develop Sequentially in One Patient

    MATSUO Toshihiko, ICHIMURA Kouichi, SHINAGAWA Katsuji

    The journal of the Japanese Society of Lymphoreticular Tissue research   52 ( 1 )   41 - 49   2012

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    In February 2002, a 42-year-old woman developed ocular adnexal extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT), MALT lymphoma, in the bilateral orbits involving lacrimal glands. She underwent 30 Gy external beam irradiation to the orbital lesions on both sides. She was well until November 2008 when she developed abdominal lymphadenopathy and transabdominal excisional biopsy showed mixed cellularity classical Hodgkin lymphoma at stage II. She underwent standard combination chemotherapy. In July 2010, she developed systemic lymphadenopathy and was diagnosed with diffuse large B-cell lymphoma (DLBCL) by cervical lymph node biopsy. She underwent rituximab monotherapy and finally allogeneic hematopoietic stem cell transplantation in October 2010, but died of renal failure in February 2011. Amplification by polymerase chain reaction of the immunoglobulin heavy chain gene gave rise to dominant discrete fragments of the same size between the orbital lesion with MALT lymphoma in 2002 and the cervical lymph node lesion with DLBCL in 2010. The sequential development of MALT lymphoma, Hodgkin lymphoma, and DLBCL in the long-term course of this patient suggests the common origin of the neoplastic cells, changing their pathological faces in response to irradiation and combination chemotherapy. [J Clin Exp Hematopathol 52(1) : 41-49, 2012]

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  • アレルギーの臨床「アトピー性皮膚炎の眼合併症:白内障と網膜剥離」

    松尾俊彦

    アレルギーの臨床   32 ( 6 )   510 - 515   2012

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  • Optical coherence tomographic parameters as objective signs for visual acuity in patients with retinitis pigmentosa, future candidates for retinal prostheses (vol 14, pg 140, 2011)

    Miho Tamaki, Toshihiko Matsuo

    JOURNAL OF ARTIFICIAL ORGANS   14 ( 4 )   385 - 385   2011.12

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  • Long-Term Effect of External Beam Radiotherapy of Optic Disc Hemangioma in a Patient with von Hippel-Lindau Disease

    Toshihiko Matsuo, Kengo Himei, Kouichi Ichimura, Hiroyuki Yanai, Soichiro Nose, Tetsushige Mimura, Yasuyuki Miyoshi, Tomoyasu Tsushima

    ACTA MEDICA OKAYAMA   65 ( 2 )   135 - 141   2011.4

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  • Retinal Vasoproliferative Granulomatous Lesion Associated with Hand Pyoderma Caused by Streptococcus pyogenes

    Toshihiko Matsuo, Miho Tamaki, Takashi Oono

    OCULAR IMMUNOLOGY AND INFLAMMATION   19 ( 1 )   58 - 61   2011.2

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  • Denaturation temperature of dried lens tissue rises with trehalose pretreatment

    Jianan Sun, Toshihiko Matsuo, Tetsuya Uchida

    JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY   103 ( 1 )   387 - 391   2011.1

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  • Immunoglobulin G4 (IgG4)-Positive or -Negative Ocular Adnexal Benign Lymphoid Lesions in Relation to Systemic Involvement

    MATSUO Toshihiko, ICHIMURA Kouichi, SATO Yasuharu, TANIMOTO Yasushi, KIURA Katsuyuki, KANAZAWA Sou, OKADA Toshiaki, YOSHINO Tadashi

    The journal of the Japanese Society of Lymphoreticular Tissue research   50 ( 2 )   129 - 142   2011

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    The purpose of this study is to determine the relationship of ocular adnexal benign or reactive lymphoid hyperplasia, including orbital pseudotumor, with immunoglobulin G4 (IgG4)-related diseases. Medical charts of 9 consecutive patients with ocular adnexal benign lymphoid lesions, seen in the Department of Ophthalmology, Okayama University Hospital, were reviewed, and pathological sections were restained immunohistochemically for IgG4-, IgG-, and CD138-positive plasma cells. The diagnosis of IgG4-positive lesions was based on 10 or more IgG4-positive plasma cells in a high-power field and greater than 40% ratios of IgG4-positive plasma cells/CD138-positive plasma cells and IgG4-positive plasma cells/IgG-positive plasma cells. IgG4-positive lesions were determined as absent in 5 patients (4 with bilateral lacrimal/orbital lesions and one with a unilateral conjunctival lesion), none of whom showed systemic manifestations. In contrast, IgG4-positive lesions were present in 4 patients (3 with bilateral lacrimal/orbital lesions and one with a unilateral lacrimal/orbital lesion), who showed systemic manifestations : one with Hashimoto thyroiditis, one with IgG4-positive bilateral interstitial lung disease and hepatic inflammatory pseudotumor, one with bilateral interstitial lung disease, and one with systemic lymphadenopathy and antiphospholipid syndrome. In conclusion, IgG4-positive ocular adnexal benign lymphoid lesions might be used as a benchmark for the probable presence of other systemic lymphoid lesions.

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  • Bilateral conjunctival lesions in blastic plasmacytoid dendritic cell neoplasm.

    Toshihiko Matsuo, Kouichi Ichimura, Takehiro Tanaka, Shin Morizane, Keiji Iwatsuki, Motoharu Eguchi, Tadashi Yoshino

    Journal of clinical and experimental hematopathology : JCEH   51 ( 1 )   49 - 55   2011

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    The purpose of this study is to report on a patient who developed conjunctival lesions of blastic plasmacytoid dendritic cell neoplasm (BPDCN) after radiation to skin lesions of the same pathological type. A 79-year-old man developed salmon-pink lesions in the lower fornix of the conjunctiva of both eyes and biopsy revealed BPDCN. One and a half years previously, he noticed an erythematous plaque with a 30-mm diameter, which later became multiple, on the left chest, and the biopsy revealed BPDCN. The bone marrow was negative for CD56-positive cells, but fluorescence-activated cell sorting analysis of peripheral blood cells revealed a group of cells positive for CD4 and CD56, or CD4 and CD123. The monocyte fraction, in an increased percentage of white blood cell counts, did contain atypical cells positive for the three markers. Whole-body 2-[(18)F]fluoro-2-deoxy-D-glucose positron emission tomography combined with computed tomography demonstrated no abnormal uptake lesions. He received 30 Gy of radiation to the chest lesions, and later, the same dose of radiation to novel skin lesions on the back, waist, and chest, and also to pharyngeal lesions. In conclusion, the conjunctiva could be involved with BPDCN and pathological differential diagnosis by biopsy is mandatory to establish the correct diagnosis.

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  • Local Recurrence as Immunoglobulin G4 (IgG4)-Related Disease 10 Years after Radiotherapy to Ocular Adnexal Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue

    MATSUO Toshihiko, ICHIMURA Kouichi, YOSHINO Tadashi

    The journal of the Japanese Society of Lymphoreticular Tissue research   51 ( 2 )   125 - 133   2011

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    In 2000, a 48-year-old woman developed a left orbital mass with lacrimal gland involvement and then, in 2003, a right orbital mass with lacrimal gland involvement, both of which were diagnosed as extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). She underwent 30 Gy external beam radiation to bilateral orbital lesions. The lymphoma cells in both lesions did not share the same clonality, as shown by amplification by polymerase chain reaction of the immunoglobulin heavy chain gene. Immunoglobulin light chain analysis by immunohistochemistry and messenger RNA in situ hybridization showed λ chain monotype in the left orbital lesion but κ chain monotype in the right orbital lesion. She developed recurrent left orbital mass with high uptake on fluorodeoxyglucose positron emission tomography fused with computed tomography in 2010, and excisional biopsy disclosed the formation of follicles and infiltration with immunoglobulin G4 (IgG4)-positive plasma cells mainly in interfollicular areas. The immunoglobulin light chain analysis showed the λ chain and κ chain bitype. With the immunohistopathological diagnosis of IgG4-related disease, the serum IgG4 level was found to show elevation at 376 mg/dL, and the patient chose observation. This is the first reported case of development of IgG4-related disease after bilataral orbital MALT lymphoma with external beam radiotherapy. [J Clin Exp Hematopathol 51(2) : 125-133, 2011]

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  • Postural Stability Changes during the Prism Adaptation Test in Patients with Intermittent and Constant Exotropia

    Toshihiko Matsuo, Akiko Yabuki, Kayoko Hasebe, Yoshie Hirai Shira, Sayuri Imai, Hiroshi Ohtsuki

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   51 ( 12 )   6341 - 6347   2010.12

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  • Neuroendocrine tumor (carcinoid) metastatic to orbital extraocular muscle: Case report and literature review

    Toshihiko Matsuo, Kouichi Ichimura, Takehiro Tanaka, Tadasu Takenaka, Tadashi Nakayama

    Strabismus   18 ( 4 )   123 - 128   2010.12

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  • Outpatients Flow Management and Ophthalmic Electronic Medical Records System in University Hospital Using Yahgee Document View

    Toshihiko Matsuo, Akira Gochi, Tsuyoshi Hirakawa, Tadashi Ito, Yoshihisa Kohno

    JOURNAL OF MEDICAL SYSTEMS   34 ( 5 )   883 - 889   2010.10

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  • Two cases of corneal perforation after oral administration of nonsteroidal anti-inflammatory drugs: oral NSAID-induced corneal damage

    Ikuya Masuda, Toshihiko Matsuo, Kazuo Okamoto, Kyoko Matsushita, Hiroshi Ohtsuki

    EUROPEAN JOURNAL OF OPHTHALMOLOGY   20 ( 2 )   454 - 456   2010.3

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  • Paretic Side/Normal Side Ratios of Cross-Sectional Areas of the Superior Oblique Muscle Vary Largely in Idiopathic Superior Oblique Palsy

    Eriko Uchiyama, Toshihiko Matsuo, Sayuri Imai, Emi Itoshima

    AMERICAN JOURNAL OF OPHTHALMOLOGY   149 ( 3 )   508 - 512   2010.3

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  • Clonal Analysis of Bilateral, Recurrent, or Systemically Multifocal Ocular Adnexal Lymphoma

    MATSUO Toshihiko, ICHIMURA Kouichi, OKADA Hiroyuki, SHINAGAWA Katsuji, FUKUSHIMA Kunihiro, OKANO Mitsuhiro, OTSUKA Masaki, YOSHINO Tadashi

    The journal of the Japanese Society of Lymphoreticular Tissue research   50 ( 1 )   27 - 38   2010

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    The purpose of this study is to determine the same or different clonality between bilateral or recurrent lesions, or between or among ocular adnexal lesions and systemically multifocal lesions in 10 consecutive patients with ocular adnexal lymphoma : 8 had extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) and 2 had mantle cell lymphoma, observed from 1995 to 2008 at Okayama University Hospital. A discrete DNA fragment was generated by polymerase chain reaction amplification of the immunoglobulin heavy chain gene from all samples except for two samples of bilateral orbital mantle cell lymphoma lesions and one sample of the scalp skin MALT lymphoma lesion. The size of DNA fragments were the same between bilateral orbital or conjunctival lesions of 5 patients, between original and recurrent conjunctival lesions of one patient, between the orbital lesion and the oral cavity lesion in one patient, and among bilateral orbital lesions, buccal, rectum, and stomach lesions of one patient. Sequencing of the DNA fragments showed the same sequence between bilateral or recurrent or multifocal lesions in 8 patients except for one : the bilateral orbital lesions, rectum, and stomach lesions shared the same sequence while the buccal lesion had one nucleotide difference compared to the sequence shared by the other 4 lesions. In conclusion, bilateral, recurrent, or systemically multifocal lesions of ocular adnexal lymphoma shared the clonality between or among the lesions. [J Clin Exp Hematopathol 50(1) : 27-38, 2010]

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  • Safety, efficacy, and quality control of a photoelectric dye-based retinal prosthesis (Okayama University-type retinal prosthesis) as a medical device

    Toshihiko Matsuo, Tetsuya Uchida, Kenichi Takarabe

    JOURNAL OF ARTIFICIAL ORGANS   12 ( 4 )   213 - 225   2009.12

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  • Is Refraction with a Hand-Held Autorefractometer Useful in Addition to Visual Acuity Testing and Questionnaires in Preschool Vision Screening at 3.5 Years in Japan?

    Toshihiko Matsuo, Chie Matsuo, Keiko Kio, Naofumi Ichiba, Hiroaki Matsuoka

    ACTA MEDICA OKAYAMA   63 ( 4 )   195 - 202   2009.8

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  • Investigation of parent-of-origin effect in comitant strabismus using MOD score analysis

    Sherin Shaaban, Toshihiko Matsuo, Konstantin Strauch, Hiroshi Ohtsuki

    MOLECULAR VISION   15 ( 141-42 )   1351 - 1358   2009.7

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  • Case report and literature review of inferior rectus muscle aplasia in 16 japanese patients

    Toshihiko Matsuo, Tomoko Watanabe, Takashi Furuse, Satoshi Hasebe, Hiroshi Ohtsuki

    Strabismus   17 ( 2 )   66 - 74   2009.6

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  • Ophthalmic Artery Embolization as Pretreatment of Orbital Exenteration for Conjunctival Squamous Cell Carcinoma

    Toshihiko Matsuo, Nobuya Ohara, Yuzaburo Namba, Isao Koshima, Kentaro Ida, Susumu Kanazawa

    CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY   32 ( 3 )   554 - 557   2009.5

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  • Central Retinal and Posterior Ciliary Artery Occlusion After Intralesional Injection of Sclerosant to Glabellar Subcutaneous Hemangioma

    Toshihiko Matsuo, Hiroyasu Fujiwara, Hideo Gobara, Hidefumi Mimura, Susumu Kanazawa

    CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY   32 ( 2 )   341 - 346   2009.3

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  • Chromosomes 4q28.3 and 7q31.2 as New Susceptibility Loci for Comitant Strabismus

    Sherin Shaaban, Toshihiko Matsuo, Hirotake Fujiwara, Emi Itoshima, Takashi Furuse, Satoshi Hasebe, Qingrun Zhang, Jurg Ott, Hiroshi Ohtsuki

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   50 ( 2 )   654 - 661   2009.2

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  • Positron Emission Tomography/Computed Tomography after Immunocytochemical and Clonal Diagnosis of Intraocular Lymphoma with Vitrectomy Cell Blocks

    MATSUO Toshihiko, ICHIMURA Kouichi, ICHIKAWA Tomotsugu, OKUMURA Yoshihiro, KAJI Mitsumasa, YOSHINO Tadashi

    The journal of the Japanese Society of Lymphoreticular Tissue research   49 ( 2 )   77 - 87   2009

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    The purpose of this study is to report the role of whole-body 2-[18F] fluoro-2-deoxy-D-glucose (FDG) positron emission tomography fused with computed tomography (PET/CT) after immunocytochemical and clonal diagnosis of intraocular lymphoma with vitrectomy cell blocks. Eleven patients with intraocular lymphoma were involved in this study : 6 patients presented with vitreous opacity in both eyes and 5 patients presented with unilateral involvement. The concurrent retinal lesions were present in 6 eyes of 5 patients. Brain lymphoma was diagnosed in 7 of the 11 patients : simultaneous with eye lesions in one patient, following the eye lesions in 3, and prior to the eye lesions in 3. Vitrectomy was done in 17 eyes of the 11 patients, and vitrectomy cell blocks were processed for immunocytochemical staining and clonality analysis by polymerase chain reaction amplification of the immunoglobulin heavy chain gene. The 7 most recent patients were evaluated with fluorodeoxyglucose whole-body PET/CT. Immunocytochemical staining of vitrectomy cell blocks in all patients showed large cells which were positive for CD20 and Ki-67 but negative for CD3, consistent with diffuse large B-cell lymphoma. The size and sequence of amplified fragments of the immunoglobulin heavy chain gene were different between the lesions of both eyes in one patient while they were the same in another patient. PET/CT after the diagnosis by vitrectomy revealed abnormal uptake in the cerebellum of two patients, in the eye as a recurrent lesion of one patient, and in both eyes as residual retinal lesions of one patient. In conclusion, PET/CT could be considered as a method to confirm brain lymphoma or as a reference for initiating additional therapy in the case of eye recurrence or residual lesions after vitrectomy. The clonality of lymphoma cells was variable between the lesions in both eyes. [J Clin Exp Hematopathol 49(2) : 77-87, 2009]

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  • Electronic medical records and management of patients for ophthalmology in a university hospital using Yahgee Document/View

    63 ( 4 )   471 - 477   2009

  • Orbital exenteration after transarterial embolization in a patient with Wyburn-Mason syndrome: Pathological findings

    Toshihiko Matsuo, Hiroyuki Yanai, Kenji Sugiu, Susumu Tominaga, Yoshihiro Kimata

    JAPANESE JOURNAL OF OPHTHALMOLOGY   52 ( 4 )   308 - 313   2008.7

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  • Short-term biological safety of a photoelectric dye used as a component of retinal prostheses

    Kazuo Okamoto, Toshihiko Matsuo, Takayuki Tamaki, Akihito Uji, Hiroshi Ohtsuki

    JOURNAL OF ARTIFICIAL ORGANS   11 ( 1 )   45 - 51   2008.4

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  • Lacrimal sac vascular leiomyoma

    Toshihiko Matsuo, Kouichi Ichimura

    JAPANESE JOURNAL OF OPHTHALMOLOGY   52 ( 2 )   130 - 131   2008.4

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  • Glial reaction to photoelectric dye-based retinal prostheses implanted in the subretinal space of rats

    Takayuki Tamaki, Toshihiko Matsuo, Osamu Hosoya, Kimiko M. Tsutsui, Tetsuya Uchida, Kazuo Okamoto, Akihito Uji, Hiroshi Ohtsuki

    JOURNAL OF ARTIFICIAL ORGANS   11 ( 1 )   38 - 44   2008.4

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  • Clinical features, ARIX and PHOX2B nucleotide changes in three families with congenital superior oblique muscle palsy

    Sayuri Imai, Toshihiko Matsuo, Emi Itoshima, Hiroshi Ohtsuki

    ACTA MEDICA OKAYAMA   62 ( 1 )   45 - 53   2008.2

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  • 眼科「Schwartz症候群」

    松尾俊彦

    眼科   50   1428 - 1429   2008

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  • 下直筋欠損の1例

    渡辺智子, 松尾俊彦, 古瀬尚, 長谷部聡, 柳川俊博, 清水敏成, 大月洋

    臨床眼科   62   1309 - 1314   2008

  • Body sway and body center changes after prism adaptation in exotropic patients : preliminary report

    YABUKI Akiko, HASEBE Kayoko, HIRAI Yoshie, MATSUO Toshihiko, OTSUKI Hiroshi

    Folia japonica de ophthalmologica clinica   1 ( 2 )   144 - 147   2008

  • Different Histopathological Types of Orbital Lymphoma 16 Years after Systemic Follicular Lymphoma : Immunohistochemical and Immunogenetic Analyses of Two Cases

    MATSUO Toshihiko, ICHIMURA Kouichi, SHINAGAWA Katsuji, YOSHINO Tadashi

    The journal of the Japanese Society of Lymphoreticular Tissue research   48 ( 1 )   17 - 24   2008

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    The purpose of this study is to show that the histopathological type of an orbital lymphoma can differ from the systemic follicular lymphoma that precedes it. A 44-year-old man (Patient #1) and a 50-year-old man (Patient #2) presented with generalized lymphadenopathy due to grade 1 follicular lymphoma proven on lymph node biopsy. Patient #1 was followed without treatment for 16 years when he developed a right orbital mass. Patient #2 underwent several courses of combination chemotherapy as well as radiation but relapsed. The second biopsy of the lymph node nine years later showed the same histopathological type of follicular lymphoma. He developed an orbital mass on the right side 16 years after the initial presentation. In Patient #1, excisional biopsy of the orbital masses showed extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). In Patient #2, biopsy revealed the orbital mass to be T-cell/histiocyte-rich diffuse large B-cell lymphoma. In Patient #1, when comparing the original lymph node biopsy to the orbital biopsy obtained years later, no evidence for clonality was noted by polymerase chain reaction. In Patient #2, the amplification by polymerase chain reaction of the immunoglobulin heavy chain gene rearrangement in the lymph node lesion and the orbital lesion gave rise to a single discrete band with the same DNA sequence except for five nucleotide changes, indicating the same clonality in the presence of genomic changes. In conclusion, orbital lymphomas can occur as a second lymphoma with a different histopathological type in the long-term follow-up of systemic lymphomas. The original and subsequent lymphomatous lesions may or may not share neoplastic cell clonality and all genomics. [J Clin Exp Hematopathol 48(1) : 17-24, 2008]

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  • Schwartz症候群

    松尾俊彦

    眼科   50   1428 - 1429   2008

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  • Comparison of prevalence rates of strabismus and amblyopia in Japanese elementary school children between the years 2003 and 2005

    Toshihiko Matsuo, Chie Matsuo

    ACTA MEDICA OKAYAMA   61 ( 6 )   329 - 334   2007.12

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  • Vogt-koyanagi-harada syndrome in two patients with immunoglobulin a nephropathy

    Toshihiko Matsuo, Ikuya Masuda, Kosuke Ota, Ichiro Yamadori, Reiko Sunami, Soichiro Nose

    ACTA MEDICA OKAYAMA   61 ( 5 )   305 - 309   2007.10

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  • Visual acuity and perimacular retinal layers detected by optical coherence tomography in patients with retinitis pigmentosa

    Toshihiko Matsuo, Noriko Morimoto

    BRITISH JOURNAL OF OPHTHALMOLOGY   91 ( 7 )   888 - 890   2007.7

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  • Eye manifestations in patients with perinuclear antineutrophil cytoplasmic antibody-associated vasculitis: Case series and literature review

    Toshihiko Matsuo

    JAPANESE JOURNAL OF OPHTHALMOLOGY   51 ( 2 )   131 - 138   2007.3

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  • Detection of strabismus and amblyopia in 1.5-and 3-year-old children by a preschool vision-screening program in Japan

    Toshihiko Matsuo, Chie Matsuo, Hiroaki Matsuoka, Keiko Kio

    ACTA MEDICA OKAYAMA   61 ( 1 )   9 - 16   2007.2

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  • 岡山県医師会報「角膜移植へのご理解を! 善意とボランティアの輪で成り立つ臓器移植」

    松尾俊彦

    岡山県医師会報   ( 1218 )   421 - 422   2007

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  • 非ステロイド性抗炎症薬内服中の結合組織病患者2例に発生した角膜融解穿孔

    増田郁也, 松尾俊彦, 松下恭子, 岡本和夫, 大月 洋

    臨床眼科   61   1861 - 1866   2007

  • 網膜色素変性の白内障手術結果と患者の満足度 ―ロービジョンケアの立場からの考察―

    守本典子, 松尾俊彦, 大月 洋

    日本眼科紀要   58   153 - 157   2007

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  • Spontaneous Regression of Bilateral Conjunctival Extranodal Marginal Zone B-cell Lymphoma of Mucosa-Associated Lymphoid Tissue

    MATSUO Toshihiko, ICHIMURA Kouichi, YOSHINO Tadashi

    The journal of the Japanese Society of Lymphoreticular Tissue research   47 ( 2 )   79 - 81   2007

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    We report the case of a patient who showed spontaneous regression of bilateral conjunctival extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). A 72-year-old man underwent excisional biopsy for salmon-pink lesions involving the whole circumference of the conjunctiva in the right eye and the lower fornix in the left eye. Histopathology and immunohistochemistry showed MALT lymphoma with immunoglobulin kappa monotype shared by the lesions in both eyes. Because the patient had recurrent pulmonary tuberculosis, radiation initially planned for the large residual lesion in the right eye was postponed. Over two years, including 6 mon with anti-tuberculous treatment, the large lesion in the right eye showed spontaneous regression. The spontaneous regression of conjunctival MALT lymphoma observed in this patient suggests that following excisional biopsy for histopathological diagnosis, observation is a treatment option. [J Clin Exp Hematopathol 47(2) : 79-81, 2007]

    DOI: 10.3960/jslrt.47.79

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  • 臨床眼科「眼科専門医に必要な「全身疾患と眼」のすべて 8.血液・造血器疾患および悪性腫瘍 白血病、悪性リンパ腫」

    松尾俊彦

    臨床眼科   61 増刊号   146 - 156   2007

  • BRAIN and NERVE 特集 最近注目される脳神経疾患治療の研究 視機能再生工学 ―光電変換色素をポリエチレン・フィルムに固定した人工網膜(岡山大学方式人工網膜)の開発―

    松尾俊彦

    BRAIN and NERVE   59   331 - 338   2007

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  • 岡山県眼科医会会報「学校眼科検診と学校眼科医」

    松尾俊彦

    岡山県眼科医会会報   145   27 - 31   2007

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  • Corneal perforation in two cases of connective tissue disease during treatment with peroral nonsteroidal anti-inflammatory drug

    Ikuya Masuda, Toshihiko Matsuo, Kyoko Matsushita, Kazuo Okamoto, Hiroshi Ohtsuki

    Japanese Journal of Clinical Ophthalmology   61 ( 10 )   1931 - 1934   2007

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  • Intracellular calcium response and adhesiveness of chick embryonic retinal neurons to photoelectric dye-coupled polyethylene films as prototypes of retinal prostheses

    Akihito Uji, Toshihiko Matsuo, Tetsuya Uchida, Kaoru Shimamura, Hiroshi Ohtsuki

    ARTIFICIAL ORGANS   30 ( 9 )   695 - 703   2006.9

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  • Disappearance of diabetic macular hard exudates after hemodialysis introduction

    Toshihiko Matsuo

    ACTA MEDICA OKAYAMA   60 ( 3 )   201 - 205   2006.6

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  • Bartonella henselae bacilli detected in vitrectomy aspirates in a patient with massive vitreous opacity with total retinal detachment

    T Matsuo, K Notohara

    OCULAR IMMUNOLOGY AND INFLAMMATION   14 ( 1 )   47 - 49   2006.2

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  • Body sway increases immediately after Strabismus surgery

    T Matsuo, A Narita, M Senda, S Hasebe, H Ohtsuki

    ACTA MEDICA OKAYAMA   60 ( 1 )   13 - 24   2006.2

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  • Atomic force microscopic observation of trehalose-treated and dried corneal epithelial surface

    Yuko Izawa, Toshihiko Matsuo, Tetsuya Uchida, Kaoru Shimamura, Hiroshi Ohtsuki

    Cell Preservation Technology   4 ( 2 )   117 - 122   2006

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  • 岡山医学会雑誌「眼科領域のアレルギー性疾患とアトピー性皮膚炎の眼合併症」

    松尾俊彦

    岡山医学会雑誌   118,131-137   2006

  • 学校保健おかやま「岡山県内の小学校児童における斜視および弱視の頻度の再調査」

    松尾俊彦

    学校保健おかやま   37,1-4?   2006

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  • 画像ラボ「岡山大学方式の人工網膜の試作品 光電変換色素をポリエチレン・フィルムに固定した人工網膜の開発」

    松尾俊彦

    画像ラボ   17,36-34 ( 9 )   36 - 40   2006

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  • アイバンクだより 岡山県アイバンク「アイバンクあれこれ」

    松尾俊彦

    アイバンクだより 岡山県アイバンク   第13号 2-3   2006

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  • Aspergillosis causing bilateral optic neuritis and later orbital apex syndrome

    T Matsuo, K Notohara, Yamadori, I

    JAPANESE JOURNAL OF OPHTHALMOLOGY   49 ( 5 )   430 - 431   2005.9

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    DOI: 10.1007/s10384-004-0217-1

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  • Predictive factors for long-term outcome of stereoacuity in Japanese patients with pure accommodative esotropia

    Toshihiko Matsuo, Takashi Yamane, Hirotake Fujiwara, Hiroshi Ohtsuki, Yoshimasa Watanabe

    Strabismus   13 ( 2 )   79 - 84   2005.6

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    DOI: 10.1080/09273970590935084

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  • ARIX and PHOX2B polymorphisms in patients with congenital superior oblique muscle palsy

    Y Jiang, T Matsuo, H Fujiwara, S Hasebe, H Ohtsuki, T Yasuda

    ACTA MEDICA OKAYAMA   59 ( 2 )   55 - 62   2005.4

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  • First presenting signs or symptoms of sarcoidosis in a Japanese population

    T Matsuo, N Fujiwara, Y Nakata

    JAPANESE JOURNAL OF OPHTHALMOLOGY   49 ( 2 )   149 - 152   2005.3

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  • Recurrent versus non-recurrent or no eye involvement in Behcet's disease

    T Matsuo, M Itami

    OCULAR IMMUNOLOGY AND INFLAMMATION   13 ( 1 )   73 - 77   2005.2

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  • Neutrophil and lymphocyte responses to oral Streptococcus in Adamantiades-Behcet's disease

    T Kurauchi, K Yokota, T Matsuo, Y Fujinami, E Isogai, H Isogai, H Ohtsuki, K Oguma

    FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY   43 ( 2 )   125 - 131   2005.2

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  • The prevalence of strabismus and amblyopia in Japanese elementary school children

    T Matsuo, C Matsuo

    OPHTHALMIC EPIDEMIOLOGY   12 ( 1 )   31 - 36   2005.2

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  • Vitrectomy and silicone oil tamponade as an initial surgery for retinal detachment after acute retinal necrosis syndrome

    T Matsuo

    OCULAR IMMUNOLOGY AND INFLAMMATION   13 ( 1 )   91 - 94   2005.2

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  • Photoelectric dye-coupled polyethylene film as a prototype of retinal prostheses

    A Uji, T Matsuo, S Ishimaru, A Kajiura, K Shimamura, H Ohtsuki, Y Dan-oh, S Suga

    ARTIFICIAL ORGANS   29 ( 1 )   53 - 57   2005.1

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  • 血液・腫瘍科「眼科付属器に発生するリンパ腫の管理と長期予後」

    松尾俊彦

    血液・腫瘍科   51,485-496   2005

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  • Cyclic tetrasaccharide delays cataract formation in the lens in vitro

    Toshihiko Matsuo

    Cell Preservation Technology   3 ( 4 )   238 - 243   2005

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  • 臨床眼科「眼科における最新医工学 Ⅱ.視機能再生工学(3) 光電変換色素を使った人工網膜試作品の開発 -岡山大学方式の人工網膜ー」

    松尾俊彦

    臨床眼科   59,118-122   2005

  • 消化器と臨床「難治性クローン病の合併症と対応 眼科領域合併症:虹彩炎などへの対策」

    松尾俊彦

    消化器と臨床   8,443-449   2005

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  • Systemic malignant lymphoma 17 years after bilateral orbital pseudotumor

    T Matsuo, Y Sato, R Kuroda, N Matsuo, T Yoshino

    JAPANESE JOURNAL OF OPHTHALMOLOGY   48 ( 5 )   503 - 506   2004.9

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  • Trehalose versus hyaluronan or cellulose in eyedrops for the treatment of dry eye

    T Matsuo

    JAPANESE JOURNAL OF OPHTHALMOLOGY   48 ( 4 )   321 - 327   2004.7

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  • Long-term follow-up results of observation or radiation for conjunctival malignant lymphoma

    T Matsuo, T Yoshino

    OPHTHALMOLOGY   111 ( 6 )   1233 - 1237   2004.6

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  • Clinical relevance of optineurin sequence alterations in Japanese glaucoma patients

    Tomoko Umeda, Toshihiko Matsuo, Mikio Nagayama, Naoyuki Tamura, Yuko Tanabe, Hiroshi Ohtsuki

    Ophthalmic Genetics   25 ( 2 )   91 - 99   2004.6

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  • ARIX gene polymorphisms in patients with congenital superior oblique muscle palsy

    T Matsuo, Y Jiang, H Fujiwara, S Hasebe, H Ohtsuki, T Yasuda

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   45   U560 - U560   2004.4

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    DOI: 10.1136/bjo.2003.021527

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  • 岡山県内の小学校児童における斜視および弱視の頻度

    松尾俊彦

    学校保健おかやま   31,1-4   2004

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  • Prostaglamdins F2α and E2 in aqueous humor of patients with cataract surgery

    Matsuo T

    J Ocular Phamacology and Therapeutics   2004

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  • 臨床眼科「白内障手術の傾向と対策 ―術中・術後合併症と難治症例Ⅲ.ハイリスク症例 ―私はこうするアトピー性白内障」

    松尾俊彦

    臨床眼科   58,250-253   2004

  • 梅毒による続発緑内障

    松尾俊彦

    Frontiers in Glaucoma   5,48-49   2004

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  • 交感性眼炎

    松尾俊彦

    臨牀看護   30,857-859   2004

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  • Different levels of TIMPs and MMPs in human lateral and medial rectus muscle tissue excised from strabismic patients

    Mizue Kitada, Toshihiko Matsuo, Takashi Yamane, Satoshi Hasebe, Hiroshi Ohtsuki

    Strabismus   11 ( 3 )   145 - 155   2003.9

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  • Protein expression, genomic structure, and polymorphisms of oculomedin

    Nagako Fujiwara, Toshihiko Matsuo, Hiroshi Ohtsuki

    Ophthalmic Genetics   24 ( 3 )   141 - 151   2003.9

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  • Clinical correlations of aggrecan in the resected medial rectus muscle of patients with intermittent exotropia

    T Yamane, T Matsuo, S Hasebe, H Ohtsuki

    ACTA MEDICA OKAYAMA   57 ( 4 )   199 - 204   2003.8

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  • A simple method for screening photoelectric dyes towards the use for retinal prosthesis

    T Matsuo

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   44   U701 - U701   2003.5

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    DOI: 10.18926/AMO/32824

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  • Genome-wide search for comitant strabismus susceptibility loci

    H Fujiwara, T Matsuo, M Sato, T Yamane, M Kitada, S Hasebe, H Ohtsuki

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   44   U44 - U44   2003.5

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    DOI: 10.18926/AMO/32833

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  • Clinical features of comitant strabismus related to family history of strabismus or abnormalities in pregnancy and delivery

    Y Taira, T Matsuo, T Yamane, S Hasebe, H Ohtsuki

    JAPANESE JOURNAL OF OPHTHALMOLOGY   47 ( 2 )   208 - 213   2003.3

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  • 眼感染症診療ガイド Ⅱ.診断治療のポイント ぶどう膜・網膜 梅毒性ぶどう膜炎

    松尾俊彦

    臨床眼科   57,191-194   2003

  • Long-term visual outcome in primary microtropia

    T Matsuo, Y Kawaishi, R Kuroda, H Ohtsuki, Y Watanabe

    PROGRESS IN STRABISMOLOGY   169 - 171   2003

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  • 眼感染症診療ガイド Ⅱ.診断治療のポイント ぶどう膜・網膜 HTLV-Ⅰ関連ぶどう膜炎

    寺石友美子, 松尾俊彦

    臨床眼科   57,226-229   2003

  • Multiple sclerosis-like disease secondary to alpha interferon

    Toshihiko Matsuo, Ryu Takabatake

    Ocular Immunology and Inflammation   10 ( 4 )   299 - 304   2002.12

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  • Trehalose eye drops in the treatment of dry eye syndrome

    T Matsuo, Y Tsuchida, N Morimoto

    OPHTHALMOLOGY   109 ( 11 )   2024 - 2029   2002.11

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  • Frosted branch angiitis associated with Harada disease-like manifestations recurs 10 years later

    T Matsuo, N Kanata, M Itami

    JAPANESE JOURNAL OF OPHTHALMOLOGY   46 ( 6 )   682 - 684   2002.11

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  • Seropositivity of human herpesvirus-8 in patients with uveitis

    Toshihiko Matsuo, Masako Itami

    Ocular Immunology and Inflammation   10 ( 3 )   197 - 199   2002.9

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  • Choroidal Neovascularization occurring concurrently in myopic eyes of monozygotic twins

    T Matsuo, J Seguchi, F Shiraga, Y Takesue, N Sakaguchi

    OPHTHALMOLOGICA   216 ( 4 )   281 - 283   2002.7

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  • Risk factors for diabetic choroidopathy in patients with diabetic retinopathy

    C Shiragami, F Shiraga, T Matsuo, Y Tsuchida, H Ohtsuki

    GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY   240 ( 6 )   436 - 442   2002.6

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  • Submacular exudates with serous retinal detachment caused by cat scratch disease

    Toshihiko Matsuo, Mutsuko Kato

    Ocular Immunology and Inflammation   10 ( 2 )   147 - 150   2002.6

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  • Acute posterior Multifocal placoid pigment epitheliopathy and scleritis in a patient with pANCA-positive systemic vasculitis

    T Matsuo, T Horikoshi, C Nagai

    AMERICAN JOURNAL OF OPHTHALMOLOGY   133 ( 4 )   566 - 568   2002.4

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  • The incidence and pathology of conjunctival ulceration in Behcet's syndrome

    T Matsuo, M Itami, H Nakagawa, M Nagayama

    BRITISH JOURNAL OF OPHTHALMOLOGY   86 ( 2 )   140 - 143   2002.2

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  • Fluorescein angiographic features of tubulointerstitial nephritis and uveitis syndrome

    T Matsuo

    OPHTHALMOLOGY   109 ( 1 )   132 - 136   2002.1

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  • Concordance of strabismic phenotypes in monozygotic versus multizygotic twins and other multiple births

    T Matsuo, M Hayashi, H Fujiwara, T Yamane, H Ohtsuki

    JAPANESE JOURNAL OF OPHTHALMOLOGY   46 ( 1 )   59 - 64   2002.1

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  • Multiple occlusive retinal arteritis in both eyes of a patient with rheumatoid arthritis

    T Matsuo

    JAPANESE JOURNAL OF OPHTHALMOLOGY   45 ( 6 )   662 - 664   2001.11

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  • Planned two-step vitrectomy for extremely large and thick subretinal hematoma

    T Matsuo, F Shiraga, Takasu, I

    ACTA OPHTHALMOLOGICA SCANDINAVICA   79 ( 5 )   533 - 537   2001.10

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  • TIMP-1 production by bovine retinal pigment epithelial cells increases in response to cyclic mechanical stretch

    K Yamaguchi, T Matsuo, F Shiraga, H Ohtsuki

    JAPANESE JOURNAL OF OPHTHALMOLOGY   45 ( 5 )   470 - 474   2001.9

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  • Scleral infolding combined with vitrectomy and gas tamponade for retinal detachment with macular holes in highly myopic eyes

    T Matsuo, F Shiraga, Takasu, I, T Okanouchi

    JAPANESE JOURNAL OF OPHTHALMOLOGY   45 ( 4 )   403 - 408   2001.7

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  • Corneal marginal infiltration with ulcerative colitis: A case report

    T Matsuo

    CORNEA   20 ( 4 )   436 - 437   2001.5

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    DOI: 10.1097/00003226-200105000-00022

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  • Trehalose protects corneal epithelial cells from death by drying

    T Matsuo

    BRITISH JOURNAL OF OPHTHALMOLOGY   85 ( 5 )   610 - 612   2001.5

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  • Same eye recurrence of acute retinal necrosis syndrome

    T Matsuo, T Nakayama, T Baba

    AMERICAN JOURNAL OF OPHTHALMOLOGY   131 ( 5 )   659 - 661   2001.5

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  • Retinal cells produce TIMP-1 and TIMP-2 in response to cyclic mechanical stretching

    M Namba, T Matsuo, F Shiraga, H Ohtsuki

    OPHTHALMIC RESEARCH   33 ( 3 )   163 - 169   2001.5

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  • Ocular attacks after phacoemulsification and intraocular lens implantation in patients with Behcet disease

    T Matsuo, M Takahashi, Y Inoue, K Egi, Y Kuwata, A Yamaoka

    OPHTHALMOLOGICA   215 ( 3 )   179 - 182   2001.5

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  • TIMP-1 production by human scleral fibroblast decreases in response to cyclic mechanical stretching

    A Yamaoka, T Matsuo, F Shiraga, H Ohtsuki

    OPHTHALMIC RESEARCH   33 ( 2 )   98 - 101   2001.3

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  • Heredity versus abnormalities in pregnancy and delivery as risk factors for different types of comitant strabismus

    T Matsuo, T Yamane, H Ohtsuki

    JOURNAL OF PEDIATRIC OPHTHALMOLOGY & STRABISMUS   38 ( 2 )   78 - 82   2001.3

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  • 斜視の原因.

    松尾俊彦

    眼科臨床医報   95,40-44   2001

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  • アトピー白内障の原因:ある眼科医の印象から.

    松尾俊彦

    白内障学会誌   13,32-34   2001

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  • 緑内障と遺伝子診療.

    松尾俊彦

    Frontiers in Glaucoma   2,30-33   2001

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  • 両涙腺、両眼外筋肥大がみられた悪性リンパ腫の1例.

    清水敏成, 河野玲華, 松尾俊彦, 大月 洋, 品川克至, 藤原隆行, 吉野 正

    眼紀   2001

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  • 共同性内斜視の所見と背景因子との関係.

    平 由起, 松尾俊彦, 山根貴司, 河野玲華, 長谷部 聡, 大月 洋

    眼科臨床医報   2001

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  • 双生児における斜視の表現型の一致について.

    林 瑞恵, 松尾俊彦, 大月 洋, 宮川公博, 横町文子, 豊田英治, 西崎秋子, 馬場哲也, 市川理恵

    眼科臨床医報   95   423 - 427   2001

  • 両眼涙腺、両眼外眼筋肥大がみられた悪性リンパ腫の1例.

    清水敏成, 河野玲華, 松尾俊彦, 大月 洋, 品川克至, 藤原隆行, 吉野 正

    日本眼科紀要   2001

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  • Endogenous amoebic endophthalmitis

    Toshihiko Matsuo, Kenji Notohara, Fumio Shiraga, Shinya Yumiyama

    Archives of Ophthalmology   119 ( 1 )   125 - 128   2001

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  • ミヤンマー見聞緑(松尾組の雑記帳 その2)ー病院視察報告ー

    松尾俊彦

    瞳青   2001

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  • エアバック眼外傷の2例.

    野中文貴, 永山幹夫, 松尾俊彦, 白神史雄, 大月 洋

    臨床眼科   2001

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  • Isolation of cDNA clones specific to the extraocular muscle of infantile esotropia

    T Yamane, T Matsuo, H Ohtsuki

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   41 ( 4 )   S418 - S418   2000.3

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  • Retinal Vasculitis Revealed by Fluorescein Angiography in Patients With Inflammatory Bowel Disease

    MATSUO Toshihiko, YAMAOKA Akihiro

    Jpn J Ophthalmol   42 ( 5 )   398 - 400   1998.9

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  • In situ visualization of messenger RNA for basic fibroblast growth factor in living cells

    Toshihiko Matsuo

    Biochimica et Biophysica Acta - General Subjects   1379 ( 2 )   178 - 184   1998.2

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    DOI: 10.1016/S0304-4165(97)00090-1

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  • The effects of growth factors on multicellular spheroids formed by chick embryonic retinal cells

    MATSUO T

    Acta Med Okayama   51 ( 5 )   251 - 260   1997

  • Gene transfer to the retina of rat by liposome eye drops

    Toshihiko Matsuo, Ikuya Masuda, Tatsuji Yasuda, Nobuhiko Matsuo

    Biochemical and Biophysical Research Communications   219 ( 3 )   947 - 950   1996.2

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    DOI: 10.1006/bbrc.1996.0326

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  • Intracellular calcium response to hydraulic pressure in human trabecular cells

    Toshihiko Matsuo, Nobuhiko Matsuo

    British Journal of Ophthalmology   80 ( 6 )   561 - 566   1996

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    DOI: 10.1136/bjo.80.6.561

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  • Apoptosis regulated by growth factors in multicellular spheroids of trabecular cells

    T Matsuo, N Matsuo

    JAPANESE JOURNAL OF OPHTHALMOLOGY   40 ( 3 )   356 - 366   1996

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  • Bovine and porcine trabecular cells produce prostaglandin F-2 alpha in response to cyclic mechanical stretching

    T Matsuo, H Uchida, N Matsuo

    JAPANESE JOURNAL OF OPHTHALMOLOGY   40 ( 3 )   289 - 296   1996

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  • Inflammation after cataract extraction and intraocular lens implantation in patients with rheumatoid arthritis

    T. Matsuo, M. Fujiwara, N. Matsuo

    British Journal of Ophthalmology   79 ( 6 )   549 - 553   1995

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  • INTRAOPERATIVE OBSERVATION OF THE VITREOUS BASE IN PATIENTS WITH ATOPIC-DERMATITIS AND RETINAL-DETACHMENT

    T MATSUO, F SHIRAGA, N MATSUO

    RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES   15 ( 4 )   286 - 290   1995

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  • Intraoperative observation of the vitreous base in patients with atopic dermatitis and retinal detachment

    Toshihiko Matsuo, Fumio Shiraga, Nobuhiko Matsuo

    Retina   15 ( 4 )   286 - 290   1995

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  • Endogenous Aspergillus endophthalmitis associated with periodontitis

    MATSUO T

    Ophthalmologica   209   109 - 111   1995

  • EXPRESSION PATTERNS OF 2 FIBROBLAST GROWTH-FACTOR RECEPTOR GENES DURING EARLY CHICK EYE DEVELOPMENT

    H OHUCHI, E KOYAMA, F MYOKAI, T NOHNO, F SHIRAGA, T MATSUO, N MATSUO, S TANIGUCHI, S NOJI

    EXPERIMENTAL EYE RESEARCH   58 ( 6 )   649 - 658   1994.6

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  • Correspondence

    Toshihiko Matsuo

    Retina   14 ( 2 )   192   1994

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    Language:English   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)  

    DOI: 10.1097/00006982-199414020-00021

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  • Photoreceptor outer segments in aqueous humor: Key to understanding a new syndrome

    Toshihiko Matsuo

    Survey of Ophthalmology   39 ( 3 )   211 - 233   1994

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    Language:English   Publishing type:Book review, literature introduction, etc.  

    DOI: 10.1016/0039-6257(94)90195-3

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  • A mutation in the Pax-6 gene in rat small eye is associated with impaired migration of midbrain crest cells

    T. Matsuo, N. Osumi-Yamashita, S. Noji, H. Ohuchi, E. Koyama, F. Myokai, N. Matsuo, S. Taniguchi, H. Doi, S. Iseki, Y. Ninomiya, M. Fujiwara, T. Watanabe, K. Eto

    Nature Genetics   3 ( 4 )   299 - 304   1993

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  • Photoreceptor outer segments in the aqueous humor of patients with atopic dermatitis and retinal detachment

    N. Matsuo, T. Matsuo, F. Shiraga, A. Hosoda, Y. Kawanishi, S. Watanabe, H. Ohtsuki

    American Journal of Ophthalmology   115 ( 1 )   21 - 25   1993

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  • The EP_2 receptor is the predominant prostanoid receptor in the human ciliary muscle

    MATSUO T.

    Br J Ophthalmol   77,110-114   110 - 114   1993

  • Localisation of prostaglandin F_2alpha and E_2 binding sites in the human eye

    MATSUO T.

    Br J Ophthalmol   76 ( 4 )   210 - 213   1992

  • HLA-DR9 ASSOCIATED WITH THE SEVERITY OF ACUTE RETINAL NECROSIS SYNDROME

    T MATSUO, N MATSUO

    OPHTHALMOLOGICA   203 ( 3 )   133 - 137   1991

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  • EXPRESSION PATTERN OF ACIDIC AND BASIC FIBROBLAST GROWTH-FACTOR GENES IN ADULT-RAT EYES

    S NOJI, T MATSUO, E KOYAMA, T YAMAAI, T NOHNO, N MATSUO, S TANIGUCHI

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   168 ( 1 )   343 - 349   1990.4

  • RETINAL-PIGMENT EPITHELIAL TEAR IN REACTIVE LYMPHOID HYPERPLASIA OF UVEA

    T MATSUO, N MATSUO, F SHIRAGA, K TAKEUCHI

    OPHTHALMOLOGICA   200 ( 1 )   46 - &   1990

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  • RETINAL VASCULITIS AS A COMPLICATION OF RHEUMATOID-ARTHRITIS

    T MATSUO, T KOYAMA, N MORIMOTO, H UMEZU, N MATSUO

    OPHTHALMOLOGICA   201 ( 4 )   196 - 200   1990

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  • NO MAJOR DEFECT DETECTED IN THE GENE OF FAMILIAL HYPO-RETINOL-BINDING PROTEINEMIA

    T MATSUO, S NOJI, S TANIGUCHI, N MATSUO

    JAPANESE JOURNAL OF OPHTHALMOLOGY   34 ( 3 )   320 - 324   1990

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  • Retinal pigment epithelial tear in reactive lymphoid hyperplasia of uvea

    Toshihiko Matsuo, Nobuhiko Matsuo, Fumio Shiraga, Kyoko Takeuchi

    Ophthalmologica   200 ( 1 )   46 - 54   1990

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  • Acute retinal necrosis as a novel complication of chickenpox in adults

    T. Matsuo, M. Koyama, N. Matsuo

    British Journal of Ophthalmology   74 ( 7 )   443 - 444   1990

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    DOI: 10.1136/bjo.74.7.443

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  • Unusual exudative retinal detachment 9 months after scleral buckling surgery

    Toshihiko Matsuo, Koji Eguchi, Nobuhiko Matsuo

    Ophthalmologica   201 ( 2 )   79 - 82   1990

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  • KERATOMALACIA IN A CHILD WITH FAMILIAL HYPO-RETINOL-BINDING PROTEINEMIA

    T MATSUO, N MATSUO, F SHIRAGA, N KOIDE

    JAPANESE JOURNAL OF OPHTHALMOLOGY   32 ( 3 )   249 - 254   1988

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  • CHARACTERIZATION OF RETINOL-BINDING PROTEIN IN FAMILIAL HYPO-RETINOL-BINDING PROTEINEMIA

    T MATSUO, N MATSUO

    JAPANESE JOURNAL OF OPHTHALMOLOGY   32 ( 4 )   379 - 384   1988

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  • ACUTE RETINAL NECROSIS SYNDROME FOLLOWING CHICKENPOX IN PREGNANT WOMAN

    T MATSUO, A OHNO, N MATSUO

    JAPANESE JOURNAL OF OPHTHALMOLOGY   32 ( 1 )   70 - 74   1988

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  • CYTOLOGICAL AND IMMUNOLOGICAL STUDY OF THE AQUEOUS-HUMOR IN ACUTE RETINAL NECROSIS SYNDROME

    T MATSUO, T NAKAYAMA, T KOYAMA, N MATSUO

    OPHTHALMOLOGICA   195 ( 1 )   38 - 44   1987

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  • IMMUNOLOGICAL STUDIES OF UVEITIS .3. CELL-MEDIATED-IMMUNITY TO INTERPHOTO-RECEPTOR RETINOID-BINDING PROTEIN

    T MATSUO, T NAKAYAMA, T KOYAMA, M KOYAMA, S FUJIMOTO, N MATSUO

    JAPANESE JOURNAL OF OPHTHALMOLOGY   30 ( 4 )   487 - 494   1986

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  • IMMUNOLOGICAL STUDIES OF UVEITIS .2. IMMUNE-COMPLEX CONTAINING RETINAL-S-ANTIGEN IN PATIENT WITH CHRONIC INTRACTABLE UVEITIS

    T MATSUO, T NAKAYAMA, T TSUJI, T KOYAMA, N MATSUO, N KOIDE

    JAPANESE JOURNAL OF OPHTHALMOLOGY   30 ( 4 )   480 - 486   1986

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  • IMMUNOLOGICAL STUDIES OF UVEITIS .1. IMMUNE-COMPLEX CONTAINING HERPESVIRUS ANTIGENS IN 4 PATIENTS WITH ACUTE RETINAL NECROSIS SYNDROME

    T MATSUO, T NAKAYAMA, N MATSUO, N KOIDE

    JAPANESE JOURNAL OF OPHTHALMOLOGY   30 ( 4 )   472 - 479   1986

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  • Immune complex containing herpes virus antigen in a patient with acute retinal necrosis

    MATSUO T

    Am J Ophthalmol   101 ( 3 )   368 - 371   1986

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Presentations

  • 腋窩単中心性Castleman病と眼窩MALTリンパ腫併存症例:6年の経過

    松尾俊彦, 田中健大, 藤智和, 遠西大輔

    第65回日本リンパ網内系学会学術集会  2025.7.5 

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    Event date: 2025.7.3 - 2025.7.5

    Presentation type:Poster presentation  

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  • シンポジウム1.「長年の研究から見えてくる斜視研究の未来」「斜視の遺伝子研究」 Invited

    松尾俊彦

    第81回日本弱視斜視学会総会・第50回日本小児眼科学会総会  2025.6.7 

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    Event date: 2025.6.6 - 2025.6.7

    Presentation type:Symposium, workshop panel (nominated)  

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  • 脈絡膜転移をきたした乳がん5症例の病理型と臨床的特徴

    松尾俊彦, 田中健大, 土井原博義, 枝園忠彦

    第129回日本眼科学会総会  2025.4.20 

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    Event date: 2025.4.17 - 2025.4.20

    Presentation type:Oral presentation (general)  

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  • 3つの日本人対照コホートを使った内斜視、外斜視、特発性上斜筋麻痺のGWAS (genome-wide association study)

    松尾俊彦

    第17回RRM (Retina Research Meeting)  2024.11.2 

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    Event date: 2024.11.2

    Presentation type:Oral presentation (general)  

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  • 結膜原発リンパ腫の連続31症例の長期予後

    松尾俊彦, 田中健大

    第64回日本リンパ網内系学会学術集会  2024.6.29 

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    Event date: 2024.6.27 - 2024.6.29

    Presentation type:Poster presentation  

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  • Morphometric Analysis of the Eye by Magnetic Resonance Imaging in MGST2 Gene-Deficient Mice.

    Chaomulige, Toshihiko Matsuo, Kohei Sugimoto, Mary Miyaji, Osamu Hosoya, Masashi Ueda, Ryosuke Kobayashi, Takuro Horii, Izuho Hatada

    2024 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO)  2024.5.5 

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    Event date: 2024.5.5 - 2024.5.9

    Presentation type:Poster presentation  

    File: ARVO2024 Abstract Chaomulige.docx

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  • 3つの異なる対照集団に基づく斜視ゲノムワイド関連解析

    松尾 俊彦, 濱崎 一郎, 鎌谷 洋一郎, 川口 喬久, 山口 泉, 松田 文彦, 斎藤 聡, 中園 一幸, 上辻 茂男

    第128回日本眼科学会総会  2024.4.19 

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    Event date: 2024.4.18 - 2024.4.21

    Presentation type:Oral presentation (general)  

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  • 小児ぶどう膜炎 Bilateral iridocyclitis with retinal capillaritis (BIRC) 追加18症例

    松尾俊彦

    第78回日本臨床眼科学会  2024.11.14 

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    Event date: 2024

    Presentation type:Oral presentation (general)  

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  • 人工網膜(OUReP)治験に向けた非臨床有効性評価試験「マウス摘出網膜組織の活動電位誘発試験」の評価基準

    松尾俊彦, 石金浩史, 内田哲也

    第61回日本人工臓器学会大会  2023.11.10 

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    Event date: 2023.11.9 - 2023.11.11

    Presentation type:Oral presentation (general)  

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  • 岡山市三歳児健康診査でのスポットビジョンスクリーナ(SVS)屈折検査の導入効果の検証

    松尾俊彦,松尾智江,別所孝子,佐藤千従,松岡宏明

    第77回日本臨床眼科学会  2023.10.6 

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    Event date: 2023.10.6 - 2023.10.9

    Presentation type:Oral presentation (general)  

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  • シンポジウム「網膜疾患の次世代治療」有機色素分子を部材とする世界初の医療機器「光電変換色素薄膜型人工網膜(OUReP)」と視細胞保護薬の候補

    松尾俊彦, 内田哲也, 石金浩史

    第42回比較眼科学会年次大会  2023.8.26 

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    Event date: 2023.8.26 - 2023.8.27

    Presentation type:Symposium, workshop panel (nominated)  

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  • 両側涙腺原発マントル細胞リンパ腫に対する末梢血幹細胞移植後10年診た1例

    松尾 俊彦, 田中 健大, 岡田 和也, 能登原 憲司, 藤井 敬子, 藤井 伸治

    第63回日本リンパ網内系学会学術集会  2023.6.24 

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    Event date: 2023.6.22 - 2023.6.24

    Presentation type:Poster presentation  

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  • アレイが異なる対照集団によって結果が異なる斜視ゲノムワイド関連解析

    松尾俊彦, 濱崎一郎, 鎌谷洋一郎, 川口喬久, 山口泉, 松田文彦, 斎藤聡, 中園一幸, 上辻茂男

    第127回日本眼科学会総会  2023.4.7 

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    Event date: 2023.4.6 - 2023.4.9

    Presentation type:Oral presentation (general)  

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  • 岡山大学方式人工網膜:有機色素分子を部材とする世界初の医療機器「光電変換色素薄膜型人工網膜 (OUReP) Invited

    松尾俊彦, 内田哲也

    網膜色素変性症協会JRPS岡山 20周年記念行事 医療講演会  2022.11.26 

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    Event date: 2022.11.26

    Presentation type:Public lecture, seminar, tutorial, course, or other speech  

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  • シンポジウム2 次世代の人工臓器を実現するためのテクノロジー「光電変換色素薄膜型人工網膜 (OUReP) の治験に向けた有効性評価試験としてのマウス摘出網膜組織の活動電位誘発試験」

    松尾俊彦, 石金浩史, 内田哲也

    第60回日本人工臓器学会大会  2022.11.4 

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    Event date: 2022.11.3 - 2022.11.5

    Presentation type:Symposium, workshop panel (public)  

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  • シンポジウム1「視覚再生/オプトジェネティクスと創薬」有機色素分子を部材とする世界初の医療機器「光電変換色素薄膜型人工網膜 (OUReP)」 Invited

    松尾俊彦, 石金浩史, 内田哲也

    第42回日本眼薬理学会  2022.10.29 

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    Event date: 2022.10.30

    Presentation type:Symposium, workshop panel (nominated)  

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  • 白内障術後に予防的抗菌薬の全身投与は必要かを明らかにする後ろ向き観察研究

    松尾俊彦, 井口真宏, 森里典康, 村﨏辰也, 萩谷英大

    第76回日本臨床眼科学会  2022.10.15 

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    Event date: 2022.10.13 - 2022.10.16

    Presentation type:Oral presentation (general)  

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  • 有機色素分子を部材とする世界初の医療機器「光電変換色素薄膜型人工網膜 (OUReP) Invited

    松尾俊彦

    令和4年度 中国・四国地区盲学校教育研究大会(岡山大会)記念講演  2022.8.18 

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    Event date: 2022.8.18 - 2022.8.19

    Presentation type:Public lecture, seminar, tutorial, course, or other speech  

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  • サルコイドーシス経過中にびまん性大細胞B細胞リンパ腫を発症した1例

    松尾俊彦, 田中健大, 表梨華, 岡田俊明, 能登原憲司, 岡田和也

    第62回日本リンパ網内系学会学術集会  2022.6.23 

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    Event date: 2022.6.25

    Presentation type:Poster presentation  

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  • 岡山市三歳児健康診査でのスポットビジョンスクリーナ(SVS)による屈折検査導入の効果

    松尾俊彦, 松尾智江, 柏野公美, 佐藤千従, 松岡宏明

    第78回日本弱視斜視学会総会  2022.6.17 

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    Event date: 2022.6.17 - 2022.6.18

    Presentation type:Oral presentation (general)  

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  • 先天上斜筋麻痺の3家系の全ゲノム配列を使った連鎖解析と疾患関連候補遺伝子の絞込み

    松尾俊彦

    第126回日本眼科学会総会  2022.4.14 

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    Event date: 2022.4.14 - 2022.4.17

    Presentation type:Oral presentation (general)  

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  • 光電変換色素薄膜型人工網膜(OUReP) とOUReP Injectorの製造品質管理

    松尾俊彦, 内田哲也

    第26回岡山リサーチパーク研究・展示発表会~産学官連携推進セミナー~  2021.12.16 

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    Event date: 2021.12.16

    Presentation type:Public lecture, seminar, tutorial, course, or other speech  

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  • 全ゲノム配列データを使った特発性上斜筋麻痺3家系の連鎖解析による疾患関連候補遺伝子の絞込み

    松尾俊彦, 斎藤聡,中園一幸

    第14回 Retina Research Meeting  2021.12.11 

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    Event date: 2021.12.11

    Presentation type:Oral presentation (general)  

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  • 第59回日本人工臓器学会大会「光電変換色素薄膜型人工網膜(OUReP)の光誘起表面電位による網膜神経組織刺激のシミュレーション」

    松尾俊彦, 内田哲也, 山下功一郎

    第59回日本人工臓器学会大会  2021.11.27 

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    Event date: 2021.11.25 - 2021.11.27

    Presentation type:Oral presentation (general)  

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  • 第75回日本臨床眼科学会「眼表面の巨大な悪性黒色腫に対する陽子線治療」

    松尾俊彦, 山崎修, 田中 健大, 勝井邦彰, 脇隆博

    第75回日本臨床眼科学会  2021.10.28 

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    Event date: 2021.10.28 - 2021.10.31

    Presentation type:Poster presentation  

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  • JICA Knowledge Co-Creation Program (Online): Short-term Program of Innovative Asia: Okayama University IT and RT Training Program for Supporting Health Systems "Social Systems for Healthcare in Japan"

    Toshihiko Matsuo

    JICA Knowledge Co-Creation Program (Online)  2021.10.19 

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    Event date: 2021.10.18 - 2021.10.29

    Language:English   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    File: JICA combined 3yo and OUReP 20211018.pdf

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  • 第77回日本弱視斜視学会総会「内斜視と外斜視の遺伝的背景の違い」

    松尾俊彦, 張青々, 濱崎一郎, 佐藤和広

    第77回日本弱視斜視学会総会  2021.7.2 

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    Event date: 2021.7.2 - 2021.7.3

    Presentation type:Oral presentation (general)  

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  • 第61回日本リンパ網内系学会総会「両側涙腺IgG4関連疾患の18年後に発症した全身のびまん性大細胞B細胞リンパ腫」

    松尾俊彦, 田中健大, 岡田和也, 能登原憲司

    第61回日本リンパ網内系学会総会  2021.6.25 

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    Event date: 2021.6.24 - 2021.6.27

    Presentation type:Oral presentation (general)  

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  • 第125回日本眼科学会総会「Pooled DNAの全エクソーム解析による内斜視と外斜視の量的形質遺伝子座解析」

    松尾俊彦, 張青々, 濱崎一郎, 佐藤和広

    第125回日本眼科学会総会  2021.4.9 

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    Event date: 2021.4.8 - 2021.4.11

    Presentation type:Oral presentation (general)  

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  • 第58回日本人工臓器学会大会「光電変換色素結合薄膜型人工網膜(OUReP)の治験に向けたマウス変性網膜の神経スパイク誘発試験と人工網膜注入器の開発」

    松尾俊彦, 内田哲也

    第58回日本人工臓器学会大会  2020.11.13 

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    Event date: 2020.11.12 - 2020.11.14

    Presentation type:Oral presentation (general)  

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  • 2020年度繊維学会秋季研究発表会「光電変換色素を用いた高分子薄膜型人工網膜の長期耐久性の向上」

    山下功一郎, 田中天羽, 内田哲也, 松尾俊彦

    2020年度繊維学会秋季研究発表会  2020.11.5 

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    Event date: 2020.11.5 - 2020.11.6

    Presentation type:Oral presentation (general)  

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  • 第74回日本臨床眼科学会「涙腺腫脹を契機に診断したIgG4関連疾患の血清IgG4値による経過観察」

    松尾俊彦, 田中 健大, 佐藤 康晴, 片岡 仁美, 宇賀 麻由, 遠西 大輔, 矢野 朋文

    第74回日本臨床眼科学会  2020.10.16 

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    Event date: 2020.10.15 - 2020.10.18

    Presentation type:Oral presentation (general)  

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  • 第45回日本小児眼科学会総会「若年性特発性関節炎の難治性ぶどう膜炎に対してヒュミラを導入し5年経過観察した1例」

    松尾俊彦, 八代将登

    第76回日本弱視斜視学会総会・第45回日本商機眼科学会総会合同学会  2020.6.26 

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    Event date: 2020.6.26 - 2020.6.27

    Presentation type:Oral presentation (general)  

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  • 第60回日本リンパ網内系学会総会「涙腺腫脹でIgG4関連疾患と診断された6例の血清IgG4値による長期経過観察」

    松尾俊彦, 田中健大, 佐藤康晴, 片岡仁美, 宇賀麻由, 遠西大輔, 矢野朋文

    第60回日本リンパ網内系学会総会  2020.5.28 

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    Event date: 2020.5.29 - 2020.5.30

    Presentation type:Poster presentation  

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  • 第59回日本生体医工学会大会「光電変換色素結合薄膜型人工網膜によって誘起されるrd1マウス摘出変性網膜組織の活動電位スパイク」

    松尾俊彦, 内田哲也

    第59回日本生体医工学会大会  2020.5.26 

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    Event date: 2020.5.25 - 2020.5.27

    Presentation type:Oral presentation (general)  

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  • 2020 ARVO Annual Meeting "A new knock-out mouse model (MGST2 gene knock-out) of strabismus."

    Chaomulige, Toshihiko Matsuo, Shihui Liu, Mary Miyaji, Osamu Hosoya, Izuho Hatada, Takuro Horii

    2020 Annual Meeting of Association for Research in Vision and Ophthalmology (ARVO)  2020.5.5 

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    Event date: 2020.5.3 - 2020.5.7

    Presentation type:Poster presentation  

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  • 2020 ARVO Annual Meeting "Prevent photoreceptor cells from apoptosis by a cryptocyanine drug (Nk-4), in RCS rats."

    Shihui Liu, Toshihiko Matsuo, Mary Miyaji, Osamu Hosoya

    2020 Annual Meeting of Association for Research in Vision and Ophthalmology (ARVO)  2020.5.4 

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    Event date: 2020.5.3 - 2020.5.7

    Presentation type:Poster presentation  

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  • 第124回日本眼科学会総会「21世紀出生時縦断調査における幼少時のテレビ視聴と学童期の視力低下の関連」

    松尾俊彦, 頼藤貴志

    第124回日本眼科学会総会  2020.4.17 

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    Event date: 2020.4.16 - 2020.4.19

    Presentation type:Oral presentation (general)  

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  • (2019年度難治性疾患実用化研究事業・免疫アレルギー疾患実用化研究事業合同成果報告会「岡山大学方式人工網膜(OUReP)の製造品質管理とfirst-in-human医師主導治験」

    松尾俊彦, 内田哲也, 櫻井淳, 蔵本孝一, 細谷修, 正岡英治, 劉詩卉

    (2019年度難治性疾患実用化研究事業・免疫アレルギー疾患実用化研究事業合同成果報告会)日本医療研究開発機構  2020.2.7 

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    Event date: 2020.2.7 - 2020.2.8

    Presentation type:Poster presentation  

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  • 第12回Retina Research Meeting「光電変換色素結合薄膜型人工網膜OURePによって誘起されるrd1マウス摘出変性網膜組織の活動電位スパイクの検出」

    松尾俊彦

    第12回Retina Research Meeting  2019.11.30 

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    Event date: 2019.11.30 - 2019.12.30

    Presentation type:Oral presentation (general)  

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  • 第41回日本バイオマテリアル学会「光電変換色素固定高分子薄膜型人工網膜から生じる電気刺激るが網膜細胞へ与える影響の解明」

    山下功一郎, 田中天羽, 内田哲也, 松尾俊彦, Willy Wong

    第41回日本バイオマテリアル学会  2019.11.24 

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    Event date: 2019.11.24 - 2019.11.26

    Presentation type:Oral presentation (general)  

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  • The 8th Meeting of the International Federation for Artificial Organs (IFAO2019) IFAO-APSAO Joint Symposium "Photoelectric dye-coupled polyethylene film: photoreseponsive properties evaluated by Kelvin probe and in vitro biological response detected in dystrophc retinal tissue"

    Toshihiko Matsuo, Tetsuya Uchida

    The 8th Meeting of the International Federation for Artificial Organs (IFAO2019)  2019.11.14 

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    Event date: 2019.11.13 - 2019.11.15

    Presentation type:Symposium, workshop panel (public)  

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  • 第27回プラスチック成形加工学会秋季大会「高分子結晶で被覆したナノセルロースのスケールアップ作製~作製条件と構造および分散性の関係~」

    藪根亮太, 松尾俊彦, 内田哲也

    第27回プラスチック成形加工学会秋季大会  2019.11.13 

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    Event date: 2019.11.12 - 2019.11.13

    Presentation type:Oral presentation (general)  

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  • 第27回プラスチック成形加工学会秋季大会「ポリエチレンを基板とした光電変換色素固定薄膜型人工網膜のアニオン交換と耐久性向上評価」

    田中天羽, 山下功一郎, 内田哲也, 松尾俊彦

    第27回プラスチック成形加工学会秋季大会  2019.11.12 

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    Event date: 2019.11.12 - 2019.11.13

    Presentation type:Oral presentation (general)  

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  • 2019年度繊維学会秋季研究発表会「光電変換色素固定高分子薄膜型人工網膜と双極細胞間における神経伝達機構の原理解明」

    山下功一郎, 田中天羽, 内田哲也, 松尾俊彦, Willy Wong

    2019年度繊維学会秋季研究発表会  2019.11.9 

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    Event date: 2019.11.9 - 2019.11.10

    Presentation type:Oral presentation (general)  

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  • 2019年度繊維学会秋季研究発表会「光電変換色素固定高分子薄膜型人工網膜の構造と物性評価」

    田中天羽, 山下功一郎, 内田哲也, 松尾俊彦

    2019年度繊維学会秋季研究発表会  2019.11.9 

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    Event date: 2019.11.9 - 2019.11.10

    Presentation type:Oral presentation (general)  

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  • 2019年度繊維学会秋季研究発表会「高分子結晶で被覆したセルロースナノファイバーの作製~作製条件と構造および分散性の関係~」

    藪根亮太, 松尾俊彦, 内田哲也

    2019年度繊維学会秋季研究発表会  2019.11.9 

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    Event date: 2019.11.9 - 2019.11.10

    Presentation type:Oral presentation (general)  

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  • 第34回中国四国地区高分子若手研究会「ポリエチレンを基板とした光電変換色素固定薄膜型人工網膜のアニオン交換と耐久性向上評価」

    田中天羽, 山下功一郎, 内田哲也, 松尾俊彦

    第34回中国四国地区高分子若手研究会  2019.10.31 

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    Event date: 2019.10.31 - 2019.11.1

    Presentation type:Oral presentation (general)  

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  • 第34回中国四国地区高分子若手研究会「高分子結晶で被覆したナノセルロースのスケールアップ作製と作製条件による構造および分散性の関係」

    藪根亮太, 松尾俊彦, 内田哲也

    第34回中国四国地区高分子若手研究会  2019.10.31 

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    Event date: 2019.10.31 - 2019.11.1

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  • 第73回日本臨床眼科学会「先天眼瞼下垂における不同視の発生時期」

    松尾俊彦

    第73回日本臨床眼科学会  2019.10.24 

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    Event date: 2019.10.24 - 2019.10.27

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  • 材料学会 第5回材料WEEK「高分子結晶で被覆したナノセルロースのスケールアップ作製~作製条件が構造および分散性に及ぼす影響~」

    藪根亮太, 松尾俊彦, 内田哲也

    材料学会 第5回材料WEEK  2019.10.15 

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    Event date: 2019.10.15 - 2019.10.18

    Presentation type:Oral presentation (general)  

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  • 第68回高分子討論会「高分子結晶で被覆したセルロースナノファイバーの作製~作製条件による構造と分散性の関係~」

    藪根亮太, 松尾俊彦, 内田哲也

    第68回高分子討論会  2019.9.26 

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    Event date: 2019.9.25 - 2019.9.27

    Presentation type:Oral presentation (general)  

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  • 第68回高分子討論会「光電変換色素固定高分子薄膜型人工網膜から生じる電気刺激と網膜細胞間における神経伝達機構の原理解明」

    山下功一郎, 田中天羽, 内田哲也, 松尾俊彦, Willy Wong

    第68回高分子討論会  2019.9.26 

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    Event date: 2019.9.25 - 2019.9.27

    Presentation type:Oral presentation (general)  

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  • セルロース学会第26回年次大会「高分子結晶で被覆したTEMPO酸化セルロースナノファイバーの分散性と吸着特性」

    藪根亮太, 松尾俊彦, 北村武大, 森田祐子, 内田哲也

    セルロース学会第26回年次大会  2019.7.11 

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    Event date: 2019.7.11 - 2019.7.12

    Presentation type:Oral presentation (general)  

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  • 第59回日本リンパ網内系学会総会「中枢神経系リンパ腫を発症しない眼内リンパ腫はあるか?」

    松尾俊彦, 田中健大

    第59回日本リンパ網内系学会総会  2019.6.28 

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    Event date: 2019.6.29

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  • 第75回日本弱視斜視学会総会「三桿法、静的立体視検査での基底外方、上方プリズム装用の影響」

    松尾俊彦, 細木良祐

    第75回日本弱視斜視学会総会  2019.6.14 

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    Event date: 2019.6.14 - 2019.6.15

    Presentation type:Oral presentation (general)  

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  • 第123回日本眼科学会総会「岡山大学方式人工網膜(OUReP)によるラット/マウス変性網膜の活動電位スパイク誘発」

    松尾俊彦, 寺田慧子, 櫻井省花子, 内田哲也

    第123回日本眼科学会総会  2019.4.19 

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    Event date: 2019.4.18 - 2019.4.21

    Presentation type:Poster presentation  

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  • The Future for Japanese Science: Vision towards achieving the sustainable development goals. Nature 150 Anniversary Symposium’s poster session. Photoelectric dye-coupled thin film as retinal prosthesis for the blind to gain the sight again.

    Toshihiko Matsuo, Tetsuya Uchida

    The Future for Japanese Science: Vision towards achieving the sustainable development goals. Nature 150 Anniversary Symposium’s poster session.  2019.4.4 

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    Event date: 2019.4.4

    Presentation type:Poster presentation  

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  • 疾患克服の挑戦2018(2018年度6事業合同成果報告会)「岡山大学方式人工網膜(OUReP)の製造品質管理とfirst-in-human医師主導治験」

    松尾俊彦, 内田哲也, 櫻井淳, 蔵本孝一, 細谷修, 正岡英治, 劉詩卉

    疾患克服の挑戦2018(2018年度6事業合同成果報告会)日本医療研究開発機構  2019.2.7 

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    Event date: 2019.2.7 - 2019.2.8

    Presentation type:Oral presentation (invited, special)  

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  • 招待講演「眼科領域の新薬の可能性:欧州で市販されている一般用医薬品トレハロース点眼薬」 Invited

    松尾俊彦

    令和6年度岡山県薬業協会講演会  2025.3.12 

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    Presentation type:Oral presentation (invited, special)  

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  • 「分子を使って何ができるでしょうか?」「分子を使って神経細胞を刺激しよう~光電変換色素薄膜型人工網膜の開発~ Invited

    松尾俊彦

    岡山大学大学院ヘルスシステム統合科学研究科「サイエンス・カフェ 2024」  2024.11.9 

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    Presentation type:Oral presentation (keynote)  

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  • 総合診療医(総合内科医)のための眼疾患

    松尾俊彦

    岡山県保険医協会 第343回プライマリケア懇話会  2023.6.25 

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    Presentation type:Public lecture, seminar, tutorial, course, or other speech  

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  • 岡山大学方式人工網膜:有機色素分子を部材とする世界初の医療機器「光電変換色素薄膜型人工網膜(OUReP)」:治験責任医師と治験機器提供者(予定)からの紹介

    松尾俊彦, 内田哲也

    日本網膜色素変性症協会(JRPS)徳島県支部 第19回定期総会 医療講演会  2023.5.28 

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  • 有機色素分子を素子とする世界初の医療機器「光電変換色素薄膜型人工網膜(OUReP)」:治験責任医師と治験機器提供者(予定)からの紹介

    松尾俊彦, 内田哲也

    日本網膜色素変性症協会(JRPS)新潟県支部定期総会 新潟県協会設立20周年記念医療講演会  2023.5.21 

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  • Visual evoked spike discharges of retinal ganglion cells with photoelectric dye-coupled polyethylene film.

    Hiroshi Ishikane, Jun Umemoto, Toshihiko Matsuo, Tetsuya Uchida

    2023 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO)  2023.4.26 

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    File: ARVO2023_abstract_handoputs.pdf

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  • 高分子結晶や光電変換色素での被覆によるナノセルロースの表面改質と工業材料および医用材料への応用(グループ研究)

    内田哲也, 松尾俊彦

    令和4年(2023年)度大学等シーズ発表会  2023.3.15 

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  • 「光電変換色素薄膜型人工網膜(OUReP)とOUReP Injectorの製造品質管理:医師主導治験に向けて

    松尾俊彦, 内田哲也

    第27回岡山リサーチパーク研究・展示発表会  2023.1.20 

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  • 光電変換色素薄膜型人工網膜 神経伝導メカニズム解明 岡山大と加トロント大が共同

    内田哲也, 山下功一郎, 松尾俊彦

    科学新聞 第3837号  2021.8.6 

  • 第74回日本弱視斜視学会総会「三桿法と実用視力との相関」

    第73回日本弱視斜視学会総会  2018 

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  • 第72回日本臨床眼科学会「上方結膜温存・耳側切開創からの水平方向対面通糸法による眼内レンズ縫着」

    第72回日本臨床眼科学会  2018 

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  • 第56回日本人工臓器学会大会パネルディスカッション人工臓器開発における非臨床試験「岡山大学方式人工網膜(OUReP)によるラット変性網膜の網膜電図誘発」

    第56回日本人工臓器学会大会  2018 

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  • 平成29年度「橋渡し研究戦略的プログラム」成果活用支援事業「網膜疾患」光電変換色素結合薄膜型人工網膜(OUReP)による網膜色素変性視覚喪失の改善法

    疾患克服戦略会議―網膜色素変性症ー 「光電変換色素結合薄膜型人工網膜(OUReP)による網膜色素変性視覚喪失の改善法」  2018 

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  • 第122回日本眼科学会総会「黄斑変性サル眼への岡山大学方式人工網膜(OUReP)植込みと視覚誘発電位の回復」

    第122回日本眼科学会総会  2018 

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  • 2018 ARVO Annual Meeting "Key pathways and genes influenced by a drug, NK-4(Lumin), in human neurons and Royal College Surgeon Rats."

    2018 Annual Meeting of Association for Research in Vision and Ophthalmology (ARVO)  2018 

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  • 2018年度繊維学会年次大会「光電変換色素固定ポリエチレン薄膜型人工網膜表面に結合した色素の均一性および安定性評価

    2018年度繊維学会年次大会  2018 

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  • 第57回日本リンパ網内系学会総会「乳腺リンパ腫(DLBCL)治療後に眼内リンパ腫として再発した1例」

    第58回日本リンパ網内系学会総会  2018 

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  • 平成29年度岡山大学研究シーズ発信会「光電変換色素NK-5962(林原)の視細胞保護効果~変性疾患での内服・サプリメントを目指して」

    平成29年度 岡山大学研究シーズ発信会  2017 

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  • 日本医療研究開発機構 革新的医療技術創出拠点プロジェクト 平成28年度成果報告会【シーズ発表・医療機器】岡山大学方式の人工網膜の医師主導治験の準備と実施:生物学的安全性評価・製造・品質管理・第I相・II相試験

    日本医療研究開発機構 革新的医療技術創出拠点プロジェクト 平成28年度成果報告会「岡山大学方式の人工網膜の医師主導治験の準備と実施:生物学的安全性評価・製造・品質管理・第I相・II相試験」  2017 

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  • 第121回日本眼科学会総会「共同性斜視関連遺伝子座の家系内SNP解析による遺伝子の絞り込み」

    第121回日本眼科学会総会  2017 

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  • 2017 ARVO Annual Meeting "NK-4 dye reduces the apoptosis of photoreceptor cells."

    2017 Annual Meeting of Association for Research in Vision and Ophthalmology (ARVO)  2017 

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  • 第73回日本弱視斜視学会総会「遺伝統計学によって辿り着いた共同性斜視に関連する遺伝子」

    第73回日本弱視斜視学会総会  2017 

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  • 第57回日本リンパ網内系学会総会「眼窩涙腺部腫瘍生検で木村病と確定した後にネフローゼ症候群を発症した1例」

    第57回日本リンパ網内系学会総会  2017 

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  • CNS 2017 "Retinal prostheses from stimulation to seeing."

    CNS 2017, 26th Annual Computational Neuroscience Meeting  2017 

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  • 第55回日本人工臓器学会大会「黄斑変性サル眼への岡山大学方式人工網膜(OUReP)植込みと視覚誘発電位の回復」

    第55回日本人工臓器学会大会  2017 

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  • 第71回日本臨床眼科学会シンポジウム「眼内腫瘍の最新画像診断学」「眼内腫瘍の眼底自発蛍光と広角眼底カメラ」

    第71回日本臨床眼科学会  2017 

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  • 第62回日本人類遺伝学会大会「連鎖解析と家系内相関解析によって辿り着いた共同性斜視に関連する遺伝子」

    第62回日本人類遺伝学会大会  2017 

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  • 第10回Retina Research Meeting特別講演 "Non-clinical tests and investigator-initiated clinical trial of photoelectric dye-coupled thin film retinal prosthesis (OUReP)"「光電変換色素結合薄膜型人工網膜(OUReP)の非臨床試験と医師主導治験」

    第10回Retina Research Meeting特別講演 "Non-clinical tests and investigator-initiated clinical trial of photoelectric dye-coupled thin film retinal prosthesis (OUReP)"「光電変換色素結合薄膜型人工網膜(OUReP)の非臨床試験と医師主導治験」  2017 

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  • 平成29年度岡山大学研究シーズ発信会「光電変換色素NK-5962(林原)の視細胞保護効果~変性疾患での内服・サプリメントを目指して~」

    平成29年度 岡山大学 研究シーズ発信会  2017 

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  • 第54回日本人工臓器学会大会「硝子体手術によるイヌでの岡山大学方式人工網膜(OUReP)植込みと摘出手術、摘出品の物性評価」

    第54回日本人工臓器学会大会  2016 

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  • 科学技術振興機構JST岡山大学新技術説明会「網膜神経細胞のアポトーシスを抑制する光電変換色素分子」

    科学技術振興機構JST岡山大学新技術説明会  2016 

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  • 日本医療研究開発機構AMEDプロジェクト連携シンポジウム(オールジャパンでの医療機器開発)「岡山大学方式の人工網膜の医師主導治験の準備と実施:生物学的安全性評価・製造・品質管理・第I相・II相試験」

    日本医療研究開発機構AMEDプロジェクト連携シンポジウム(オールジャパンでの医療機器開発)「岡山大学方式の人工網膜の医師主導治験の準備と実施:生物学的安全性評価・製造・品質管理・第I相・II相試験」  2016 

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  • 文部科学省・厚生労働省 革新的医療技術創出拠点プロジェクト 平成27年度成果報告会【シーズ発表・医療機器】岡山大学方式の人工網膜の医師主導治験の準備と実施:生物学的安全性評価・製造・品質管理・第I相・II相試験

    文部科学省・厚生労働省 革新的医療技術創出拠点プロジェクト 平成27年度成果報告会  2016 

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  • The 13th International Congress of Human Genetics (ICHG2016) "Candidate genes for strabismus (esotropia and exotropia) susceptibility chromosomal loci."

    The 13th International Congress of Human Genetics (ICHG2016) April 3-7, 2016, Kyoto, Japan  2016 

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  • 第120回日本眼科学会総会「岡山大学方式人工網膜(OUReP)植込み網膜色素変性(RCS)ラットでの視覚誘発電位の記録」

    第120回日本眼科学会総会  2016 

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  • 第72回日本弱視斜視学会総会「動的奥行知覚検査としての三稈法測定の再現性(続報)」

    第72回日本弱視斜視学会総会  2016 

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  • 第56回日本リンパ網内系学会総会「びまん性大細胞B細胞リンパ腫に対する自己末梢血幹細胞移植後の涙腺MALTリンパ腫」

    第56回日本リンパ網内系学会総会  2016 

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  • 「次世代AIを考える」意見交換会:新方式人工網膜「光電変換色素結合薄膜型」

    「次世代AIを考える」意見交換会  2016 

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  • LES 2016 Annual Meeting "Photoelectric dye-coupled thin film as a novel type of retinal prosthesis."

    LES (Licensing Executives Society) (USA and Canada) 2016 Annual Meeting  2016 

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  • 第70回日本臨床眼科学会シンポジウム12「眼部腫瘍診断の最前線~微量検体からわかること~」「生化学検査」

    第70回日本臨床眼科学会  2016 

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  • 第3回弘前医療技術イノベーションシンポジウム セッション2「網膜疾患に対する新規デバイスの開発」光電変換色素結合薄膜型(岡山大学方式)人工網膜OURePの医師主導治験

    第3回弘前医療技術イノベーションシンポジウム 6th World Centenarian Initiative「光をもういちどー要介護0社会を目指してー」  2016 

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  • 第53回日本人工臓器学会大会「岡山大学方式の人工網膜(OUReP)を植込んだ網膜色素変性(RCS)ラットの視覚誘発電位」

    第53回日本人工臓器学会大会  2015 

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  • 文部科学省・厚生労働省 革新的医療技術創出拠点プロジェクト 平成26年度成果報告会【シーズ発表・医療機器】岡山大学方式の人工網膜の医師主導治験:生物学的安全性評価・製造・品質管理

    文部科学省・厚生労働省 革新的医療技術創出拠点プロジェクト 平成26年度成果報告会「医療イノベーション創出ネットワークの現状と展望~新しいフェーズに入ったアカデミアのシーズ開発」  2015 

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  • 第119回日本眼科学会総会シンポジウム「神経眼科疾患における遺伝子異常ー新たな発見ー」外眼筋麻痺と原因遺伝子

    第119回日本眼科学会総会  2015 

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  • 第71回日本弱視斜視学会総会「動的奥行知覚検査としての三稈法測定の再現性」

    第71回日本弱視斜視学会総会  2015 

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  • 第55回日本リンパ網内系学会総会「網膜黄白色斑と前房蓄膿で再発した節外性NK/T細胞リンパ腫の1例」

    第55回日本リンパ網内系学会総会  2015 

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  • Bio-Japan 2015 日本医療研究開発機構AMEDブース「岡山大学方式の人工網膜の医師主導治験の準備と実施」

    Bio-Japan 2015 日本医療研究開発機構AMEDブース  2015 

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  • 第69回日本臨床眼科学会「特発性外眼筋炎7症例の長期経過」

    第69回日本臨床眼科学会  2015 

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  • 結膜デルモイドの手術例と非手術例の臨床的特徴

    第68回日本臨床眼科学会  2014 

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  • 上斜筋麻痺の手術回数に影響を与える因子

    第70回日本弱視斜視学会総会  2014 

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  • AAPOS (American Assoication for Pediatric Ophthalmology and Strabismus) and JAPO 2014 Joint Meeting "Benchmark for clinical decision-making of observation or lensectomy in patients with ectopia lentis."

    AAPOS (American Assoication for Pediatric Ophthalmology and Strabismus), JAPO (Japanese Association for Pediatric Ophthalmology), and JASA (Japanese Association for Strabismus and Ambyopia) 2014 Joint Meeting  2014 

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  • XIIth ISA (International Strabismological Association) 2014 Meeting "Candidate genes for strabismus susceptibility locus.”

    XIIth ISA (International Strabismological Association) 2014 Meeting  2014 

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  • 1歳未満児の片眼性先天白内障の第一次硝子体過形成遺残(前部型)合併と眼内レンズ挿入

    第118回日本眼科学会総会  2014 

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  • Vision recovery and retinal apoptosis reduction in RCS rats with Okayama University-type retinal prosthesis.

    2014 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2014 Annual Meeting)  2014 

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  • 慢性リンパ性白血病経過中に結膜病変生検でマントル細胞リンパ腫と診断された1例

    第54回日本リンパ網内系学会総会  2014 

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  • LES 2014 Annual Meeting "Photoelectric dye-coupled thin film as a novel type of retinal prosthesis."

    LES (Licensing Executives Society) (USA and Canada) 2014 Annual Meeting  2014 

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  • 網膜色素変性RCSラットでの岡山大学方式人工網膜の長期埋め込み効果

    第52回日本人工臓器学会大会  2014 

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  • 共同性斜視関連遺伝子座の家計内SNP解析による絞り込み

    日本人類遺伝学会 第58回大会  2013 

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  • 岡山大学方式人工網膜を埋め込んだRCSラットの行動実験による視覚と網膜神経保護

    第117回日本眼科学会総会  2013 

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  • 三稈法と静的立体視検査との相関

    第69回日本弱視斜視学会総会  2013 

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  • 岡山大学方式の人工網膜

    平成25年度 医工連携推進シンポジウム  2013 

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  • 岡山大学方式の人工網膜の医師主導治験に向けた生物学的安全性試験の実施

    第35回公益財団法人両備てい園記念財団 助成金贈呈式  2013 

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  • 小児における先天性水晶体亜脱臼の手術時期

    第67回日本臨床眼科学会  2013 

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  • 岡山大学方式の人工網膜を埋め込んだRCSラット網膜の変化

    第50回日本人工臓器学会大会  2012 

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  • 岡山大学方式の人工網膜(光電変換色素結合ポリエチレン・フィルム)の品質

    第116回日本眼科学会総会  2012 

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  • 複視が重心動揺と重心位置に及ぼす影響の再検証

    第68回日本弱視斜視学会総会  2012 

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  • 脈絡膜悪性黒色腫のPET/CTによる検出

    第66回日本臨床眼科学会  2012 

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  • 特発性(先天性)上斜筋麻痺の遺伝型と表現型との関係

    第65回 日本臨床眼科学会  2011 

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  • 結膜MALTリンパ腫のPET/CTでの評価

    戴65回日本臨床眼科学会  2011 

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  • 特発性(先天性)上斜筋麻痺の遺伝型と表現型との関係

    日本人類遺伝学会 第56回大会  2011 

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  • 岡山大学方式の人工網膜(光電変換色素結合ポリエチレン・フィルム)の感度改良

    第49回日本人工臓器学会大会  2011 

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  • 特別講演「眼科医に必要な全身疾患の知識」

    第255回広島眼科症例検討会  2011 

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  • ベーチェット病

    ベーチェット病友の会岡山県支部医療講演  2011 

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  • 炎症と病理診断された硝子体混濁の免疫染色特徴

    第115回 日本眼科学会総会  2011 

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  • 網膜色素変性

    岡山県難病相談・支援センター医療講演  2011 

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  • ケルビンプローブによる岡山大学方式人工網膜の光誘起表面電位測定

    第114回日本眼科学会総会  2010 

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  • 神経内分泌腫瘍(カルチノイド)外眼筋転移の臨床的特長

    第66回日本弱視斜視学会総会  2010 

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  • 眼付属器の良性リンパ性病変におけるIgG4陽性と全身合併症との関連

    第64回日本臨床眼科学会  2010 

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  • 人工網膜埋め込み手術前の網膜評価に光干渉断層計は使えるか?

    第48回日本人工臓器学会大会  2010 

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  • 両側、再発、全身多発性眼付属器リンパ腫のクローン解析

    第63回日本臨床眼科学会  2009 

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  • シンポジウム6「感覚系・運動系人工臓器の最近の進歩」光電変換色素結合ポリエチレン・フィルム(岡山大学方式人工網膜)のケルビンプローブによる表面電位測定

    第47回日本人工臓器学会大会  2009 

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  • シンポジウム9「網膜を材料にした多角的アプローチによる組織細胞の姿を知る」人工網膜からみた網膜神経細胞の機能

    第114回日本解剖学会総会  2009 

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  • 眼内悪性リンパ腫の病理診断確定後におけるPET/CTの役割

    台113会日本眼科学会総会  2009 

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  • 眼・中枢神経系悪性リンパ腫のクローン解析

    第112回日本眼科学会総会  2009 

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  • 視力、問診、小児科医診察の3歳児健康診査における屈折検査導入の是非

    第65回日本弱視斜視学会総会  2009 

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  • 眼内悪性リンパ腫の硝子体手術セルブロックによる病理診断とPET/CTによる評価

    第49回日本リンパ網内系学会総会  2009 

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  • 共同性斜視家系におけるインプリンティングを考慮したMODスコア解析による遺伝子座の同定

    日本人類遺伝学会第54回大会  2009 

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  • オーガナイズドセッション「ニューロエンジニアリング」 光電変換色素をつかった人工網膜(岡山大学方式人工網膜)の安全性および機能性評価

    第47回生体医工学会大会  2008 

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  • 日本で報告された先天下直筋欠損16例の特徴と発症機序

    第64回日本弱視斜視学会総会  2008 

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  • 斜視家系における斜視関連遺伝子座の全ゲノム連鎖解析

    日本人類遺伝学会第53回大会  2008 

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  • 大学病院でのヤギー文書・画像による眼科診療管理と専用電子カルテの構築

    第62回日本臨床眼科学会  2008 

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  • スペシャルセッション 日本発 人工臓器 光電変換色素を使った人工網膜(岡山大学方式人工網膜)の評価方法

    第46回日本人工臓器学会大会  2008 

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  • Safety of photoelectric dye and dye-coupled polyethylene films as prototypes of Okayama University-type retinal prostheses

    2008 Annual Meeting of the Association for Research in Vision and Ophthalmology  2008 

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  • Biological safety of photoelectric dye-coupled polyethylene films as prototypes of Okayama University-type retinal prostheses

    The 2nd Meeting of the International Federation for Artificial Organs  2007 

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  • 硝子体切除物の遠心細胞塊によって診断した眼内悪性リンパ腫

    第111回日本眼科学会総会  2007 

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  • The feasibility of photoelectric dye-coupled polyethylene films as retinal prostheses based on neuronal adn glial cell adhesion

    2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO)  2007 

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  • Reprodicibility of prevalence rates of strabismus and amblyopia in Japanese elementary school children between the year 2003 and 2005 survey

    2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO)  2007 

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  • 岡山県内の小学校児童における斜視および弱視の頻度調査の再現性

    第63回日本弱視斜視学会総会  2007 

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  • 内眼炎における硝子体手術の適応と硝子体細胞診

    平成19年度 中国四国ブロック講習会  2007 

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  • 全身濾胞性リンパ腫の16年後に発症した組織型が異なる眼かリンパ腫の2症例

    第61回日本臨床眼科学会総会  2007 

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  • 網膜色素変性症患者における網膜層構造の光干渉断層計による観察

    第60回 日本臨床眼科学会  2006 

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  • イブニングセニナー1「眼の一生」眼の再生医療に向けて考えてみよう これからの人工物 人工網膜は再生医療への橋渡しか?

    第5回日本再生医療学会総会  2006 

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  • Duane症候群におけるSALL4遺伝子多型

    第110回日本眼科学会総会  2006 

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  • The prevalence of strabismus at 1.5 and 3-year-old children in Okayama City, Japan, from 2000 to 2004

    The 2006 annual meeting of the Association for Research in Vision and Ophthalmology (ARVO)  2006 

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  • SALL4 gene polymorphisms in patients with Duane syndrome

    The 2006 annual meeting of the Association for Research in Vision and Ophthalmology (ARVO)  2006 

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  • Mixed neuronal and glial colony formation on the surface of photoelectric dye-coupled polyethylene (Okayama University type retinal prosthesis)

    The 2006 annual meeting of the Association for Research in Vision and Ophthalmology (ARVO)  2006 

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  • Atomic force microscopic observation of treahalose-treated and dried corneal surface

    The 2006 annual meeting of the Association for Research in Vision and Ophthalmology (ARVO)  2006 

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  • 岡山市の1歳6ヵ月児および3歳児健康診査における弱視・斜視の頻度

    第62回日本弱視斜視学会総会  2006 

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  • 光電変換色素を使った人工網膜

    日本人工視覚研究会 第2回人工視覚研究会  2006 

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  • pANCA(MPO-ANCA)関連血管炎でみられる眼所見

    2005年 第59回日本臨床眼科学会  2005 

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  • 人工神経・人工感覚器研究の新しい潮流 光電変換色素を使った人工網膜(岡山大学方式人工網膜)の試作品の開発

    第43回日本人工臓器学会大会  2005 

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  • 先天上斜筋麻痺の患者におけるARIX遺伝子およびPHOX2B遺伝子の多型

    第109回日本眼科学会総会  2005 

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  • Cell adhesiveness and the response of chick embryonic retinal neurons to photoelectric dye-coupled polyethylene films as a prototype of retinal prostheses

    The 2005 annual meeting of the Association for Research in Vision and Ophthalmology (ARVO)  2005 

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  • The prevalence of strabismus at 1.5 and 3-year-old children in Okayama City, Japan

    The 2005 annual meeting of the Association for Research in Vision and Ophthalmology (ARVO)  2005 

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  • Evaluation of a strabismus susceptibility locus on chromosome 7p in Japanese pedigrees

    The 2005 annual meeting of the Association for Research in Vision and Ophthalmology (ARVO)  2005 

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  • Cyclic tetrasaccharide prevents cataract formation in the lens in vitro

    The 2005 annual meeting of the Association for Research in Vision and Ophthalmology (ARVO)  2005 

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  • 外斜視手術直後の重心位置および重心動揺度の変化

    第61回日本弱視斜視学会総会  2005 

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  • Trehalose protects corneal epithelial cells from death by desiccation

    Association for Research in Vision and Ophthalmology  2001 

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  • Trehalose eyedrops in the treatment of dry eye syndrome

    105th Annual Meeting of the American Academy of Ophthalmology  2001 

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Works

  • 岡山大学方式人工網膜の開発の現況と今後の展開

    2007

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    Work type:Artistic work  

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Awards

  • 日本人工臓器学会 2014年度論文賞(広領域)

    2014  

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    Country:Japan

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  • 2013年度 日本弱視斜視学会賞(弓削賞)

    2013  

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    Country:Japan

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  • 日本眼科学会評議員会賞

    2007  

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    Country:Japan

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  • 平成17年11月22日 岡山県ベンチャー・ビジネスプランコンテスト審査員特別賞

    2005  

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    Country:Japan

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  • 平成8年度公益信託須田賞(日本緑内障学会賞)

    1997  

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    Country:Japan

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  • 結城賞

    1994  

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    Country:Japan

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  • 日本弱視斜視学会賞(弓削賞)

    1989  

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    Country:Japan

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  • 日本人工臓器学会 第50回大会論文中の最優秀論文Tominaga Award2013

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    Country:Japan

    2103

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Research Projects

  • Narrowing of strabismus susceptibility loci by SNP analysis using family members

    Grant number:23659811  2011

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

    MATSUO Toshihiko

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    Grant amount:\3120000 ( Direct expense: \2400000 、 Indirect expense:\720000 )

    We analyzed 400 SNPs in two chromosomal loci, 4q28. 3 and 7q31. 2, which were discovered by our previous studies. The SNPs were typed with mass array in the Central Research Laboratories of Okayama University Medical School. We divided families members into two groups : patients with strabismus and other members with no diseases and compared the SNPs to find the significant difference between the two groups.

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  • Safety and efficacy of photoelectric dye-coupled polyethylene films (Okayama University-type retinal prostheses)

    Grant number:18591922  2006 - 2008

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    MATSUO Toshihiko, UCHIDA Tetuya

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    Grant amount:\3880000 ( Direct expense: \3400000 、 Indirect expense:\480000 )

    光電変換色素をポリエチレン・フィルムに結合した人工網膜(岡山大学方式人工網膜)の試作品は、網膜神経細胞や網膜組織を刺激し、人工網膜として機能することを示してきた。この研究では、人工網膜の機能と安全性について検討した。人工網膜表面に培養した網膜神経細胞は、光刺激に反応して、細胞内カルシウムイオンの上昇をきたすことを明らかにした。また、素材として、ポリエチレン・フィルムの結晶状態を変えると、グリア細胞が付着しにくい人工網膜を作成することが可能になった。安全性としては、人工網膜の素材として使っている光電変換色素は、光照射下でも網膜神経細胞や網膜色素上皮細胞に対して毒性がないことを証明した。また、人工網膜をラット眼球の網膜下へ埋め込む手術方法を開発し、その組織反応を調べた。その結果、グリアの増殖反応はみられるが、網膜神経細胞に対しては悪影響を及ぼさないことが判明した。網膜色素変性症のモデルラット(RCSラット)の眼球内の網膜下に人工網膜を埋め込むと、失明状態から視覚を回復させることを、ラットの行動実験から明らかにした。

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  • Immobilization of Photoelectric Dye on the Polyethylene Film Surface -A Prototype Retinal Prosthesis-

    Grant number:17560605  2005 - 2006

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    UCHIDA Tetsuya, SHIMAMURA Kaoru, MATSUO Toshihiko

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    Grant amount:\3600000 ( Direct expense: \3600000 )

    Polyethylene (PE) film was treated with fuming nitric acid at 80°C for 20 min, resulting in introduction of COOH moieties on the film surface. The COOH's were reacted with ethylenediamine, whose amino groups were used for linking with (2-[4-(dibutylamino)phenyl]ethenyl)-3-carboxy-methylbenzo-thiazolium, photoelectric dye (NK-5962), which absorbs visible light and converts the photon energy to electric potentials. The dye molecules were immobilized on the PE film surface and they were able to stimulate chick retinal tissues on incidence of visible light. These facts hopefully lead to development of an artificial retinal prosthesis.

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  • ARIX gene polymorphisms in patients with congenital superior oblique muscle palsy

    Grant number:15591858  2003 - 2005

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    MATSUO Toshihiko, OHTSUKI Hiroshi

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    Grant amount:\1900000 ( Direct expense: \1900000 )

    To identify ARIX gene and PHOX2B gene polymorphisms in patients with congenital superior oblique muscle palsy, 3 exons of the ARIX gene and PHOX2B gene were sequenced by genomic DNA amplification with polymerase chain reaction (PCR) and direct sequencing in 31 patients with congenital superior oblique muscle palsy and in 54 normal individuals. A family with a father and one daughter each having congenital superior oblique muscle palsy was also included in this study. Eleven patients with congenital superior oblique muscle palsy had heterozygous nucleotide changes in the ARIX gene, including 4 patients reported on previously. One patient with atrophy of the superior oblique muscle had a new change of T-4G in the promoter region of the ARIX gene. The other 6 patients had a heterozygous nucleotide change of G153A in the 5'-untranslated region (UTR) of the exon 1 of the ARIX gene. These nucleotide changes of the ARIX gene, taken together, had a significant association with congenital superior oblique muscle palsy (P=0.0022). One patient and 5 patients had heterozygous nucleotide changes of A1106C and A1121C in exon 3 of the PHOX2B gene, respectively, while these changes were absent in the normal individuals. Two patients had both the G153A change in the 5'-UTR of exon 1 of the ARIX gene and the A1121C change in exon 3 of the PHOX2B gene. In conclusion, the polymorphisms of the ARIX gene and PHOX2B gene may be genetic risk factors for the development of congenital superior oblique muscle palsy.

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  • Genetic studies of strabismus

    Grant number:13671840  2001 - 2003

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    OHTSUKI Hiroshi, MATSUO Toshihiko

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    Grant amount:\3600000 ( Direct expense: \3600000 )

    To elucidate the role of extracelluar matrix components such as aggrecan, fibronectin and laminin in the extraocular muscle of patients with strabismus, this study underwent. Resected tissues of the medial rectos muscle of 47 patients with intermittent exotropia obtained during strabismus surgery, were frozen under liquid nitrogen and pulverized by a Freezer/Mill to solubilize the tissue for enzyme immunoassay. Aggrecan was measured with Human aggrecan Kit, and for fibronectin and laminin measurements, competitive biding assay was applied by using Quanti Matrix Human Fibronectin Elisa Kit and Quanti Matrix Human Laminin Elisa. The amounts in unit length (mm) of aggrecan, fibronectin, and laminin in the resected tissue were used for statistical analysis to find the relationship with clinical data of patients, such as age, exodeviation, refractive error, pre and postoperative eye position, binocular function, type of intermittent exotropia, family history, abnormalities in pregnancy and delivery. The amount of aggrecan decreased significantly with the advance of age (p<0.0001, Spearman rank correlation test), while the amount of laminin or fibronectin had no correlation with age. Patients with basic type intertmittent exotropia showed larger, although not significantly, amounts of aggrecan than those with convergence insufficiency type (p=0.0538, Mann-Whitney U-test). From these results we concluded that the amounts of aggrecan possibly be related to motor aspecis of intermittent exotropia.

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  • Isolation of cDNA Clones Specific to the Estraocular Muscle of the Infantile Esotropia

    Grant number:10671644  1998 - 1999

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    OHTSUKI Hiroshi, HASEBE Satoshi, MATSUO Toshihiko

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    Grant amount:\3000000 ( Direct expense: \3000000 )

    To elucidate the underlying mechanism of infantile esotropia, we tried to determine mRNA which was expressed specifically in the extraocular muscle in patients with infantile esotropia. Fragments of the extraocular muscle excised during strabismus surgery in patients with infantile esotropia or intermittent exotropia were immediately frozen in liquid nitrogen and stored at -135C until use. The excised fragments were from the lateral rectus muscle in patients with infantile esotropia, while from the medial rectus muscle in patients with intermittent exotropia. The muscle fragments were pulverized in liquid nitrogen, and mRNA was isolated, followed by synthesis of cDNA. Subtractive hybridization based on suppression polymerase chain reaction (PCR) was used to isolate cDNAs which were expressed selectively in muscle fragments of infantile esotropia, compared with muscle fragments of intermittent exotropia. The cDNA were cloned into pCRII-TOPO vector. Dot-blot morthern blot analysis was used to examine the expression of isolated cDNA clones in muscle fragments of infantile esotropia or intermittent exotropia. We found that DNA smear, extending from 100 to 500 base pairs, was amplified by nested PCR from suppression PCR products after two rounds of hybridization. The smear DNA was cloned, and 240 plasmic clones were obtained. Dot-blot northern blot analysis confirmed that 10 clones were selectively expressed in muscle fragments of infantile esotropia, compared with muscle fragments of intermittent exotropia. Sequencing of these clones and GenBAnk search revealed that the sequence had no match to the known cDNA.

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  • Molecular biological and biochemical study of intraocular pressure-sensing mechanism

    Grant number:09470380  1997 - 1999

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    MATSUO Toshihiko, NAKAGAWA Hideki

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    Grant amount:\10300000 ( Direct expense: \10300000 )

    We demonstrated that cultured bovine trabecular cells produced tissue inhibitor of metalloproteinase-1 (TIMP-1) and matrix metalloproteinase-2 (MMP-2) in response to cyclic mechanical stretching for 72 hours. Cyclic mechanical stretching was applied to cultured cells in 6-cm petri dishes at the magnitude of 4500 microstrain and at a cycle of 30 seconds. Human trabecular cells also expressed a novel gene in response to cyclic mechanical stretching for 24 hours. This new gene was isolated by subtractive hybridization based on suppression polymerase chain reaction. Messenger RNA was isolated from stretched trabecular cells and control trabecular cells, and cDNA was synthesized. Control cell-derived cDNA was subtracted from stretched cell-derived cDNA. The subtracted cDNA fragments were cloned into a plasmid vector. The expression of each clone in stretched cells and in control cells was examined by Northern blot hybridization. The corresponding full-length cDNA was then isolated by screening of human eye cDNA LIBRARY. These facts suggest that trabeuclar cells respond to mechanical stimuli and that an intraocular-sensing mechanism is present in trabecular cells.

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  • Basic and Clinical Studies on Choroidal Circulation and its Disorders

    Grant number:04404068  1992 - 1994

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for General Scientific Research (A)

    MATSUO Nobuhiko, KAWANISHI Yojiro, SHIRAGA Fumio, OHSHIMA Kohichi, NAKAGAWA Hideki, MATSUO Toshihiko

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    Grant amount:\26000000 ( Direct expense: \26000000 )

    1. Studies on nerve factors and endothelial factors which regulate choroidal circulation. (1) Nerve factors - Both nor - adrenergic and acetylcholin - esterage positive nerve fibers were distributed around smooth muscle cells of choroidal arterioles of rabbits. Adrenergic nerve endings were also recognized close to choroidal melanocytes of monkeys. Choroidal blood flow increased significantly after cutting the cervical sympathetic nerve in rabbits, and decreased after stimulating it. (2) Prostaglandins - Choroidal blood flow of rabbits increased significantly after administrating a small dose of prostaglandin IィイD22ィエD2 - derivative and EィイD21ィエD2. (3) It was suggested that the renin - angiotensin system was involved in choroidal circulation. (4) Choroidal blood flow of rabbits decreased significantly after intravenous or intravitreal injection of endothelin (ET) - 1. An endothelin A - receptor anatagonist improved choroidal circulatory disorders of rats when ET - 1 participated in the disorder.
    (5) Choroidal blood flow of rabbits decreased significantly after intravenous administration of specific inhibitor of an endothelium - derived relaxing factor. (6) Choroidal blood flow decreased significantly in rabbits with selective damage of the retinal layer. The structure of choriocapillaris was thought to be regulated by the retinal pigment epithelium. From above results, choroidal circulation was regulated by both nerve and endothelial factors, and also by choroidal melanocytes and the retinal outer layer. There also seemed to be a possibility of autoregulation of choroidal circulation.
    2. Basic and clinical studies on indocyanine green video angiography using the scanning laser ophthalmoloscope. (1) The diameters of choroidal vessels were measured digitally by using the scanning laser ophthalmoscope and image analysis system. This digital technique was useful for measuring how the diameters of choroidal vessels of experimental animals were changed especially after medical treatment. (2) This technique was also useful for the clinical detection of the choroidal circulatory disorder in various fundus diseases, especially the early detection of feeder vessels into subfoveal choroidal neovascularization of age - related macular degeneration. And selective localized laser photocoagulation for the feeder vessels were effective to age - related macular degeneration.

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