Faculty Profiles - MATSUMOTO Yosuke

Papers - MATSUMOTO Yosuke

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Helping-Like Behaviour in Mice Towards Conspecifics Constrained Inside Tubes Reviewed International journal

Ueno H, Suemitsu S, Murakami S, Kitamura N, Wani K, Matsumoto Y, Okamoto M, Ishihara T

Scientific Reports 9 ( 5817 ) 5817 - 5817 2019

Language：English Publishing type：Research paper (scientific journal)

Prosocial behaviour, including helping behaviour, benefits others. Recently, helping-like behaviour has been observed in rats, but whether it is oriented towards rescue, social contact with others, or other goals remains unclear. Therefore, we investigated whether helping-like behaviour could be observed in mice similar to that in rats. Because mice are social animals widely used in neuroscience, the discovery of helping-like behaviour in mice would be valuable in clarifying the psychological and biological mechanisms underlying pro-sociability. We constrained mice inside tubes. Subject mice were allowed to move freely in cages with tubes containing constrained conspecifics. The subject mice released both cagemates and stranger mice but did not engage in opening empty tubes. Furthermore, the same behaviour was observed under aversive conditions and with anesthetised conspecifics. Interestingly, hungry mice opened the tubes containing food before engaging in tube-opening behaviour to free constrained conspecifics. Mice showed equal preferences for constrained and freely moving conspecifics. We demonstrated for the first time that mice show tube-opening behaviour. Furthermore, we partly clarified the purpose and motivation of this behaviour. An effective mouse model for helping-like behaviour would facilitate research on the mechanisms underlying prosocial behaviour.

DOI： 10.1038/s41598-019-42290-y

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Alteration of Parvalbumin Expression and Perineuronal Nets Formation in the Cerebral Cortex of Aged Mice Reviewed International journal

Ueno H, Fujii K, Takao K, Suemitsu S, Murakami S, Kitamura N, Wani K, Matsumoto Y, Okamoto M, Ishihara T

Molecular and Cellular Neuroscience 95 31 - 42 2019

Language：English Publishing type：Research paper (scientific journal)

Aging is associated with decline in cognitive function, but the underlying mechanisms have not been elucidated. Normal activity of pyramidal cells and parvalbumin-expressing interneurons (PV neurons) is essential for cognitive function. PV neurons participate in the regulation of pyramidal-cell firing. Abnormal function of PV neurons may occur with aging. We analyzed the density and the percentage of PV neurons surrounded by perineuronal nets (PNNs) in the entire cortex of adult (3-month-old) and aged (24-month-old) mice. PNNs are extracellular matrix molecules that cover PV neurons and control synaptic plasticity. PV-neuron density decreased in some cortical areas of aged compared to adult mice. In particular, in the retrosplenial granular cortex (RSG) of aged mice, pyramidal cells expressed PV protein at high levels. This study suggests that the RSG of aged mice is in an abnormal activated state. RSG function abnormality may be part of the cognitive decline mechanism.

DOI： 10.1016/j.mcn.2018.12.008

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Anti-depressive-like effect of 2-phenylethanol inhalation in mice Reviewed International journal

Ueno H, Shimada A, Suemitsu S, Murakami S, Kitamura N, Wani K, Matsumoto Y, Okamoto M, Ishihara T

Biomedicine & Pharmacotherapy 111 1499 - 1506 2019

Language：English Publishing type：Research paper (scientific journal)

Rose oil has traditionally been used to treat psychiatric disorders, but the scientific basis of this treatment remains poorly understood. The main odor component of rose oil is 2-phenylethanol (2-PE), but the neuropsychological effects of 2-PE have not been investigated in detail. Thus, we aimed to investigate the effects of 2-PE on mouse behavior. We first investigated whether 2-PE is attractive or repulsive to mice. After 2-PE inhalation, the mice underwent a series of behavioral experiments, such as the elevated plus maze, open field, Y-maze, tail-suspension, and Porsolt forced-swim tests. Mice did not have a strong interest in 2-PE but were not repelled by it nor were fearful. In the open field test, mice that had inhaled 2-PE spent less time in the center area, while in the tail suspension test, their immobility time decreased. There was no change in cognitive function, activity level, muscle strength, or aggression in these mice. Our results suggest that 2-PE elicits neuropsychological effects that alter the behavior of mice and may also elicit anti-depressive effects. Inhalation of rose oil containing 2-PE may be effective against depression and stress-related diseases.

DOI： 10.1016/j.biopha.2018.10.073

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Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in mice Reviewed International journal

Ueno H, Shimada A, Suemitsu S, Murakami S, Kitamura N, Wani K, Matsumoto Y, Okamoto M, Fujiwara Y, Ishihara T

Heliyon 5 ( 6 ) e01945 - e01945 2019

Language：English Publishing type：Research paper (scientific journal)

Rosa gallica, a plant of the Rosa genus, has been used widely since the 13th century and is cultivated in many areas as a medicinal plant for the preparation of herbal medicines. However, details of the neuropsychological effects of R. gallica remain unclear; therefore we aimed to investigate the neuropsychological effects of a water-soluble extract of R. gallica in male C57BL/6N mice under normal conditions and under chronic stress. We administered a water-soluble extract of R. gallica to mice and performed a series of behavioral experiments to compare the treated animals with the untreated controls. No significant differences in activity level, anxiety-like behavior, depression-like behavior, body weight, and body temperature were observed between R. gallica-treated mice and control mice. However, in mice subjected to chronic stress, the observed decrease in activity was smaller in the R. gallica-treated mice than in the control mice. The oral administration of R. gallica did not affect the normal behavior of mice. However, when the mice were subjected to stress, R. gallica exerted an anti-stress effect. Therefore, R. gallica has potential as a medicinal plant for the purpose of stress prevention.

DOI： 10.1016/j.heliyon.2019.e01945

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Attenuation Effects of Alpha-Pinene Inhalation on Mice with Dizocilpine-Induced Psychiatric-like Behaviour Reviewed International journal

Ueno H, Shimada A, Suemitsu S, Murakami S, Kitamura N, Wani K, Matsumoto Y, Okamoto M, Ishihara T

Evidence-Based Complementary and Alternative Medicine 2745453 1 - 12 2019

Language：English Publishing type：Research paper (scientific journal)

α-Pinene, an organic terpene compound found in coniferous trees, is used as a safe food additive and is contained in many essential oils. Moreover, some studies have shown that α-pinene suppresses neuronal activity. In this study, we investigated whether inhalation of α-pinene suppresses dizocilpine (MK-801-) induced schizophrenia-like behavioural abnormalities in mice. Mice inhaled α-pinene 1 h before the first MK-801 injection. Thirty minutes after MK-801 injection, the open field, spontaneous locomotor activity, elevated plus maze, Y-maze, tail suspension, hot plate, and grip strength tests were conducted as behavioural experiments. Inhalation of α-pinene suppressed the activity of mice in the spontaneous locomotor activity test and although it did not suppress the MK-801-induced increased locomotor activity in the open field test, it remarkably decreased the time that the mice remained in the central area. Inhalation of α-pinene suppressed the MK-801-induced increased total distance travelled in the Y-maze test, whereas it did not alter the MK-801-induced reduced threshold of antinociception in the hot plate test. In the tail suspension and grip strength tests, there was no effect on mouse behaviour by administration of MK-801 and inhalation of α-pinene. These results suggest that α-pinene acts to reduce MK-801-induced behavioural abnormalities resembling those seen in neuropsychiatric disorders. Therefore, both medicinal plants and essential oils containing α-pinene may have potential for therapeutic treatment of schizophrenia.

DOI： 10.1155/2019/2745453

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Behavioural Effects of Inhalation Exposure to Dizocilpine (MK-801) in Mice Reviewed International journal

Ueno H, Suemitsu S, Murakami S, Kitamura N, Wani K, Takahashi Y, Matsumoto Y, Okamoto M, Ishihara T

Biomedicine & Pharmacotherapy 117 ( 109038 ) 109038 - 109038 2019

Language：English Publishing type：Research paper (scientific journal)

The complex pathophysiology of brain disorders and the difficulty of delivering therapeutic agents to the brain remain major obstacles in the research and development of new therapeutic methods for brain disorders. Therefore, delivering existing therapeutic agents to the central nervous system is expected to provide benefits in various diseases. In this study, we investigated whether inhaled central nervous system drugs reached the brain and affected mouse behaviour. Dizocilpine (MK-801), which increases locomotor activity in mice, was mainly used to study this hypothesis. First, we administered MK-801, an N-methyl-d-aspartate receptor antagonist, to mice via inhalation and examined whether it induced excessive activity similar to that observed after intraperitoneal administration. We also examined the time- and dose-dependency of drug induced changes in mouse behaviour after MK-801 inhalation. Next, we investigated whether inhalation of scopolamine, pentobarbital, and imipramine also affected mouse behaviour. Mice that inhaled MK-801 showed MK-801-induced hyperactivity similar to that observed following intraperitoneal administration. Furthermore, the extent of activity changed in a time- and dose-dependent manner after MK-801 inhalation. Inhalation of pentobarbital, scopolamine, and imipramine also changed mouse behaviour. These results demonstrate that inhalation of MK-801 exerts effects similar to those achieved with intraperitoneal and oral administration in mice. Thus, central nervous system agonists can reach the brain efficiently via inhalation. This finding may facilitate the development of improved therapies for brain disorders.

DOI： 10.1016/j.biopha.2019.109038

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Comprehensive Behavioral Study of the Effects of Vanillin Inhalation in Mice Reviewed International journal

Ueno H, Shimada A, Suemitsu S, Murakami S, Kitamura N, Wani K, Takahashi Yu, Matsumoto Y, Okamoto M, Fujiwara Y, Ishihara T

Biomedicine & Pharmacotherapy 115 ( 108879 ) 108879 - 108879 2019

Language：English Publishing type：Research paper (scientific journal)

Vanillin is widely used in food and cosmetics, among other substances, for its sweet smell. However, the neuropsychological effects of vanillin inhalation have not been elucidated. In this study, we investigated the effect of vanillin inhalation on mouse behavior. First, we investigated whether the aroma of vanillin was attractive or repulsive for mice. Thereafter, the mice inhaled vanillin for 20 min before each test in a series of behavioral tests (elevated plus maze, open field, Y-maze, tail suspension, cotton bud biting, and Porsolt forced swim tests). In these tests, the mice showed a neutral response to vanillin. Mice that inhaled vanillin had a suppressed pain response in the hot plate test. In addition, the grip strength of the forelimbs of mice that inhaled vanillin was decreased. No significant differences were found between the mice inhaling vanillin and control mice in the open field, Y-maze, tail suspension, forced swimming, and aggression tests. These results show that vanillin inhalation has anti-nociceptive effects, similar to other routes of administration. The results also show that vanillin inhalation does not cause significant behavioral effects.

DOI： 10.1016/j.biopha.2019.108879

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Rescue-like Behaviour in Mice is Mediated by Their Interest in the Restraint Tool Reviewed International journal

Ueno H, Suemitsu S, Murakami S, Kitamura N, Wani K, Takahashi Y, Matsumoto Y, Okamoto M, Ishihara T

Scientific Reports 10648 ( 1 ) 10648 - 10648 2019

Language：English Publishing type：Research paper (scientific journal)

Acting without the expectation of compensation is called prosocial behaviour. Since prosocial behaviour requires high cognitive and social abilities, it has been thought to be only shown by primates. Although prosocial behaviour has been recently reported in rats, there are still questions regarding this finding. We demonstrated rescue-like behaviour in mice in a previous report. In this study, we investigated the motives underlying rescue-like behaviour for constrained cage-mates among mice. We prepared either a tube containing a ball of yarn or an opaque tube and assessed whether mice displayed the same rescue-like behaviour shown in the case of tube-restrained cage-mates. Mice did not open the lid of the tube containing the ball of yarn but opened the opaque tube lid. Mice showed a high interest in the tube in which the cage-mate had been restrained and prioritized staying in this tube rather than rescuing additional cage-mates. Oxytocin, which increases empathy, had no effect on the lid-opening behaviour. Thus, the rescue-like behaviour of mice is not based on empathy but is related to social interest in the cage-mate and the tube itself. These results suggest that rodent lid-opening behaviour may not conclusively prove the presence of prosocial behaviour.

DOI： 10.1038/s41598-019-46128-5

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Alteration of extracellular matrix molecules and perineuronal nets in the hippocampus of pentylenetetrazol-kindled mice Reviewed International journal

Ueno H, Suemitsu S, Murakami S, Kitamura N, Wani K, Takahashi Y, Matsumoto Y, Okamoto M, Ishihara T

Neural Plasticity 8924634 1 - 14 2019

Language：English Publishing type：Research paper (scientific journal)

The pathophysiological processes leading to epilepsy are poorly understood. Understanding the molecular and cellular mechanisms involved in the onset of epilepsy is crucial for drug development. Epileptogenicity is thought to be associated with changes in synaptic plasticity; however, whether extracellular matrix molecules-known regulators of synaptic plasticity-are altered during epileptogenesis is unknown. To test this, we used a pentylenetetrazole- (PTZ-) kindling model mouse to investigate changes to hippocampal parvalbumin- (PV-) positive neurons, extracellular matrix molecules, and perineuronal nets (PNNs) after the last kindled seizure. We found an increase in Wisteria floribunda agglutinin- (WFA-) and Cat-315-positive PNNs and a decrease in PV-positive neurons not surrounded by PNNs, in the hippocampus of PTZ-kindled mice compared to control mice. Furthermore, the expression of WFA- and Cat-315-positive molecules increased in the extracellular space of PTZ-kindled mice. In addition, consistent with previous studies, astrocytes were activated in PTZ-kindled mice. We propose that the increase in PNNs after kindling decreases neuroplasticity in the hippocampus and helps maintain the neural circuit for recurrent seizures. This study shows that possibility of changes in extracellular matrix molecules due to astrocyte activation is associated with epilepticus in PTZ-kindled mice.

DOI： 10.1155/2019/8924634

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Hyaluronic Acid is Present on Specific Perineuronal Nets in the Mouse Cerebral Cortex Reviewed International journal

Ueno H, Suemitsu S, Murakami S, Kitamura N, Wani K, Matsumoto Y, Okamoto M, Aoki S, Ishihara T

Brain Research 1698 139 - 150 2018.11

Language：English Publishing type：Research paper (scientific journal)

In the central nervous system (CNS), extracellular matrix (ECM) molecules comprise more than 20% of the volume and are involved in neuronal plasticity, synaptic transmission, and differentiation. Perineuronal nets (PNNs) are ECM molecules that highly accumulate around the soma of neurons. The components of the ECM in the CNS include proteins, proteoglycans, and glycosaminoglycans. Although hyaluronic acid (HA) is considered a constituent element of PNNs, the distribution of HA in the cortex has not been clarified. To elucidate the cortical region-specific distribution of HA, we quantitatively analyzed HA binding protein (HABP)-positive PNNs in the mature mouse cerebral cortex. Our findings revealed that HABP-positive PNNs are present throughout the mouse cortex. The distribution of many HABP-positive PNNs differed from that of Wisteria floribunda agglutinin-positive PNNs. Furthermore, we observed granular-like HABP-positive PNNs in layer 1 of the cortex. These findings indicate that PNNs in the mouse cortex show region-dependent differences in composition. HABP-positive PNNs in layer 1 of the cortex may have different functions such as neuronal differentiation, proliferation, and migration unlike what has been reported for PNNs so far.

DOI： 10.1016/j.brainres.2018.08.011

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精神疾患併存が肝移植レシピエントの生存に与える影響

木村宏之, 岸辰一, 岡田剛史, 成田尚, 田中輝明, 町野彰彦, 松本洋輔, 藤澤大介, 大橋綾子, 光安博志, 野間俊一, 西村勝治, 川嵜弘詔, 小倉靖弘, 尾崎紀夫

移植 53 ( 総会臨時 ) 531 - 531 2018.9

Empathic behavior according to the state of others in mice International journal

Hiroshi Ueno, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Motoi Okamoto, Yosuke Matsumoto, Shozo Aoki, Takeshi Ishihara

Brain and Behavior 8 ( 7 ) e00986 2018.7

戸籍の性別の「変更」ではなく「訂正」が認められた46、XX副腎皮質過形成症の2例. Reviewed

大島義孝、松本洋輔、佐藤俊樹、山田了士

GID(性同一性障害)学会雑誌 10 ( 1 ) 41 - 48 2018.3

Juvenile stress induces behavioral change and affects perineuronal net formation in juvenile mice Reviewed International journal

Ueno H, Suemitsu S, Murakami S, Kitamura N, Wani K, Matsumoto Y, Okamoto M, Aoki S, Ishihara T

BMC Neuroscience 19 ( 41 ) 41 - 41 2018

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Many neuropsychiatric disorders develop in early life. Although the mechanisms involved have not been elucidated, it is possible that functional abnormalities of parvalbumin-positive interneurons (PV neurons) are present. Several previous studies have shown that juvenile stress is implicated in the development of neuropsychiatric disorders. We aimed to clarify the effects of juvenile stress on behavior and on the central nervous system. We investigated behavioral abnormalities of chronically-stressed mice during juvenilehood and the effect of juvenile stress on PV neurons and WFA-positive perineuronal nets (PNNs), which are associated with vulnerability and plasticity in the mouse brain. RESULTS: Due to juvenile stress, mice showed neurodevelopmental disorder-like behavior. Juvenile stressed mice did not show depressive-like behaviors, but on the contrary, they showed increased activity and decreased anxiety-like behavior. In the central nervous system of juvenile stressed mice, the fluorescence intensity of WFA-positive PNNs decreased, which may signify increased vulnerability. CONCLUSION: This study suggested that juvenile stressed mice showed behavioral abnormalities, resembling those seen in neuropsychiatric disorders, and increased brain vulnerability.

DOI： 10.1186/s12868-018-0442-z

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Empathic Behaviour According to the State of Others in Mice Reviewed

Ueno H, Suemitsu S, Murakami S, Kitamura N, Wani K, Okamoto M, Matsumoto Y, Aoki S, Ishihara T

Brain and Behavior 8 ( e00986 ) e00986 - e00986 2018

Vaginoplasty in gender identity disorder male-to-female transsexuals

Yuzaburv Namba, Yoshihiro Kimala, Yosuke Matsumoto, Morito Sugimoto, Mikiya Nakatsuka

Japanese Journal of Plastic Surgery 57 ( 8 ) 867 - 873 2014

非けいれん性てんかん発作重積を呈した1例

千田真友子, 松本洋輔, 水木寛, 高木学, 岡部伸幸, 内富庸介

精神神経学雑誌 115 ( 6 ) 681 - 682 2013.6

Factors predicting psychiatric co-morbidity in gender-dysphoric adults. Reviewed

Terada S, Matsumoto Y, Sato T, Okabe N, Kishimoto Y, Uchitomi Y

Psychiatry Res 200 ( 2-3 ) 469 - 474 2012.12

A Case of Adult-onset Adrenoleukodystrophy with Frontal Lobe Dysfunction：A Novel Point Mutation in the ABCD1 Gene Reviewed

Inoue S, Terada S, Matsumoto T, Ujike H, Uchitomi Y

Intern Medicine 51 ( 11 ) 1403 - 1406 2012.1

岡山大学病院ジェンダークリニックにおける性同一性障害治療の現状と一般精神科臨床と同障害の関わりについて

松本洋輔, 岡部伸幸, 佐藤俊樹, 山本文子, 太田順一郎, 中島豊爾, 横山茂生, 大西勝, 井戸由美子, 黒田重利

精神神経学雑誌 111 ( 6 ) 711 - 711 2009.6

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Papers - MATSUMOTO Yosuke