Faculty Profiles - MATSUMOTO Yosuke

Papers - MATSUMOTO Yosuke

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臓器移植希望者(レシピエント)の心理社会的評価に関する提言

西村勝治, 井上真一郎, 大橋綾子, 岡田剛史, 桂川修一, 木村宏之, 小林清香, 成田尚, 中西健二, 松本洋輔, 日本総合病院精神医学会臓器不全・臓器移植関連委員会

総合病院精神医学 33 ( 3 ) 246 - 285 2021.7

Collective Housing of Mice of Different Age Groups before Maturity Affects Mouse Behavior. Reviewed International journal

Hiroshi Ueno, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yu Takahashi, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara

Behavioural neurology 2020 6856935 - 6856935 2020.11

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Although population housing is recommended by many animal management and ethical guidelines, the effect of collective housing of mice of different age groups on mouse behavior has not been clarified. Since the development of the central nervous system continues to occur before sexual maturation, the stress of social ranking formation among male individuals in mixed housing conditions can affect postmaturation behavior. To assess these effects, sexually immature mice of different ages were housed in the same cage and a series of behavioral tests were performed after maturation. RESULTS: The findings for three groups of mice-junior mice housed with older mice, senior mice housed with younger mice, and mice housed with other mice of the same age-were compared. Junior mice showed higher body weight and activity as well as lower grip strength and anxiety-like behaviors than other mice. In contrast, senior mice showed lower body temperature and increased aggression, antinociceptive effect, and home-cage activity in the dark period in comparison with other mice. CONCLUSIONS: Thus, combined housing of immature mice of different age groups affects mouse behavior after maturation. Appropriate prematuration housing conditions are crucial to eliminate the uncontrollable bias caused by age-related social stratification.

DOI： 10.1155/2020/6856935.

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Hexanal inhalation affects cognition and anxiety-like behavior in mice International journal

Hiroshi Ueno, Atsumi Shimada, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yu Takahashi, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara

Zeitschrift fur Naturforschung - Section C Journal of Biosciences 75 ( 11-12 ) 409 - 415 2020.11

てんかん発作後に精神病症状と生活史健忘を認め、遷延する健忘がてんかん性か解離性かの区別に苦慮した1例. Reviewed

深尾貴志、藤原雅樹、松本洋輔、山田了士

精神神経学雑誌 122 ( 9 ) 703 - 703 2020.9

自閉スペクトラム症を背景にもち断食を試みた自殺企図に対し、治療および社会支援を導入した1例. Reviewed

加藤朱万理、植田真司、藤原雅樹、松本洋輔、山田了士

精神神経学雑誌 122 ( 9 ) 700 - 701 2020.9

Effects of haloperidol inhalation on MK-801- and memantine-induced locomotion in mice. Reviewed International journal

Hiroshi Ueno, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yu Takahashi, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara

The Libyan journal of medicine 15 ( 1 ) 1808361 - 1808361 2020.8

Language：English Publishing type：Research paper (scientific journal)

UNLABELLED: The administration of therapeutic agents is difficult in many patients, such as patients with post-operative delirium or dementia or patients with schizophrenia, who are upset in an emergency room. Therefore, the development of a new method for administering therapeutic agents to the central nervous system is desired. In this study, we investigated if inhalation was an effective route of administration for haloperidol, a commonly used, strong antipsychotic. Dizocilpine, also known as MK-801, is a noncompetitive antagonist of the N-methyl-D-aspartate receptor. MK-801 or memantine-induced motor hyperactivity was evaluated in mice following either intraperitoneal injection or inhalation of haloperidol or the histamine neuroactivator betahistine. Pretreatment with haloperidol inhalation inhibited the MK-801-induced or memantine-induced increase in locomotor activity. This effect was similar to that of the intraperitoneal administration of haloperidol. However, pretreatment with inhaled betahistine or the intraperitoneal administration of betahistine did not suppress the MK-801-induced or memantine-induced increase in locomotor activity. Thus, haloperidol when inhaled acts on the central nervous system of mice and suppresses the MK-801-induced increase in mouse locomotor activity. Our findings suggest that inhalation may be a novel method for administering haloperidol. ABBREVIATIONS: ANOVA: analysis of variance.

DOI： 10.1080/19932820.2020.1808361

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Pentylenetetrazol kindling induces cortical astrocytosis and increased expression of extracellular matrix molecules in mice. Reviewed

Ueno H, Suemitsu S, Murakami S, Kitamura N, Wani K, Takahashi Yu, Matsumoto Y, Okamoto M, Ishihara T

Brain Res Bull 163 120 - 134 2020.7

Alpha-pinene and dizocilpine (MK-801) attenuate kindling development and astrocytosis in an experimental mouse model of epilepsy. Reviewed

Ueno H, Suemitsu S, Murakami S, Kitamura N, Wani K, Takahashi Yu, Matsumoto Y, Okamoto M, Ishihara T

IBRO Rep 9 102 - 114 2020.7

Behavioural Changes in Mice after Getting Accustomed to the Mirror Reviewed International journal

Ueno H, Suemitsu S, Murakami S, Kitamura N, Wani K, Takahashi Y, Matsumoto Y, Okamoto M, Ishihara T

Behavioural Neurology 4071315 4071315 - 4071315 2020

Language：English Publishing type：Research paper (scientific journal)

Patients with brain function disorders due to stroke or dementia may show inability to recognize themselves in the mirror. Although the cognitive ability to recognize mirror images has been investigated in many animal species, the animal species that can be used for experimentation and the mechanisms involved in recognition remain unclear. We investigated whether mice have the ability to recognize their mirror images. Demonstrating evidence of this in mice would be useful for researching the psychological and biological mechanisms underlying this ability. We examined whether mice preferred mirrors, whether plastic tapes on their heads increased their interest, and whether mice accustomed to mirrors learnt its physical phenomenon. Mice were significantly more interested in live stranger mice than mirrors. Mice with tape on their heads spent more time before mirrors. Becoming accustomed to mirrors did not change their behaviour. Mice accustomed to mirrors had significantly increased interest in photos of themselves over those of strangers and cage-mates. These results indicated that mice visually recognized plastic tape adherent to reflected individuals. Mice accustomed to mirrors were able to discriminate between their images, cage-mates, and stranger mice. However, it is still unknown whether mice recognize that the reflected images are of themselves.

DOI： 10.1155/2020/4071315.

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Increased anxiety-related behavior in mice following b-citronellol inhalation Reviewed International journal

Ueno H, Shimada A, Suemitsu S, Murakami S, Kitamura N, Wani K, Yu Takahashi, Matsumoto Y, Okamoto M, Ishihara T

Libyan Journal of Medicine in press ( 1 ) 1767275 - 1767275 2020

Language：English Publishing type：Research paper (scientific journal)

β-Citronellol is a monoterpene alcohol found in essential oils of various aromatic plant species. The physiological effects of β-citronellol inhalation on the central nervous system remain unclear. We investigated the effects of β-citronellol inhalation on mouse behavior. First, we examined whether the odor of β-citronellol was attractive or repellent to mice. Then, following 30 minutes of β-citronellol inhalation, a series of behavioral tests (elevated plus maze, open field, Y-maze, tail suspension, and forced swim tests) were performed. Mice were neither attracted to nor repelled by β-citronellol. Mice that inhaled β-citronellol showed an increase in anxiety-like behavior in the elevated plus maze and open field tests. Performance in the Y-maze and forced swim tests was not affected. These results indicate that β-citronellol acts on the central nervous system of mice following inhalation and increases anxiety. Essential oils and cosmetics containing β-citronellol should be used with caution.

DOI： 10.1080/19932820.2020.1767275

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Effects of repetitive gentle handling of male C57BL/6NCrl mice on comparative behavioural test results Reviewed International journal

Ueno H, Takahashi Y, Suemitsu S, Murakami S, Kitamura N, Wani K, Matsumoto Y, Okamoto M, Ishihara T

Scientific Reports 10 ( 3509 ) 3509 - 3509 2020

Language：English Publishing type：Research paper (scientific journal)

Mice are the most commonly used laboratory animals for studying diseases, behaviour, and pharmacology. Behavioural experiment battery aids in evaluating abnormal behaviour in mice. During behavioural experiments, mice frequently experience human contact. However, the effects of repeated handling on mice behaviour remains unclear. To minimise mice stress, methods of moving mice using transparent tunnels or cups have been recommended but are impractical in behavioural tests. To investigate these effects, we used a behavioural test battery to assess differences between mice accustomed to the experimenter's handling versus control mice. Repeatedly handled mice gained slightly more weight than control mice. In behavioural tests, repeatedly handled mice showed improved spatial cognition in the Y-maze test and reduced anxiety-like behaviour in the elevated plus-maze test. However, there was no change in anxiety-like behaviour in the light/dark transition test or open-field test. Grip strength, rotarod, sociability, tail suspension, Porsolt forced swim, and passive avoidance tests revealed no significant differences between repeatedly handled and control mice. Our findings demonstrated that mice repeatedly handled by the experimenter before behavioural tests showed reduced anxiety about high altitudes and improved spatial cognition, suggesting that repeated contact can affect the results of some behavioural tests.

DOI： 10.1038/s41598-020-60530-4

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Hexanal inhalation affects cognition and anxiety-like behavior in mice Reviewed

Ueno H, Shimada A, Suemitsu S, Murakami S, Kitamura N, Wani K, Takahashi Y, Matsumoto Y, Okamoto M, Ishihara T

Zeitschrift für Naturforschung C in press 409 - 415 2020

Caffeine Inhalation Effects on Locomotor Activity in Mice Reviewed International journal

Ueno H, Takahashi Y, Suemitsu S, Murakami S, Kitamura N, Wani K, Matsumoto Y, Okamoto M, Ishihara T

Drug Development and Industrial Pharmacy in press ( 5 ) 778 - 794 2020

Language：English Publishing type：Research paper (scientific journal)

It is estimated that 80% of the world's population consumes caffeine from beverages and food every day. The traditional form of caffeine intake is oral, but more recently people have been inhaling caffeine using nasal sprays. However, the effects of caffeine inhalation are not well understood. The purpose of this study was to determine whether caffeine inhalation affects mouse behavior. To test this, we compared spontaneous activity of mice following inhalation and intraperitoneal administration of caffeine. Next, we investigated whether spontaneous activity changed with the time and/or concentration of caffeine inhaled. We found that mice that inhaled caffeine increased their spontaneous activity similar to mice that were administered caffeine intraperitoneally. Furthermore, spontaneous activity increased in an inhalation time-dependent and concentration-dependent manner. These results show that caffeine-induced stimulation also occurs by inhalation in mice, which suggests that caffeine can reach the brain even by inhalation. This study is useful not only for creating new administration methods of caffeine but also for adjusting caffeine storage and management.

DOI： 10.1080/03639045.2020.1753064

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Conformity-like Behaviour in Mice Observing the Freezing of Other Mice: A Model of Empathy Reviewed International journal

Ueno H, Suemitsu S, Murakami S, Kitamura N, Wani K, Takahashi Y, Matsumoto Y, Okamoto M, Ishihara T

BMC Neuroscience in press ( 1 ) 19 - 19 2020

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Empathy refers to the ability to recognise and share emotions with others. Several research groups have recognised observational fear in mice as a useful behavioural model for assessing their ability to empathise. However, in these observation systems, it remains unclear whether the observer mouse truly recognises the movements of, and empathises with, the demonstrator mouse. We examined changes in the behaviour of an observer mouse when a demonstrator mouse was anaesthetised, when the demonstrator's activity was increased, and when the interval of electrical stimulation was altered. If mice exhibit an ability to empathise, then the observer should display empathic behaviour when the demonstrator experiences pain or discomfort under any circumstances. RESULTS: Relative to low-frequency stimulation, frequent electrical stimulation reduced immobility time among observer mice. Moreover, when demonstrators exhibited excessive activity, the activity of the observers significantly increased. In addition, the proportion of immobility time among observer mice significantly increased when demonstrator mice exhibited fear learning and excessive immobility. CONCLUSION: Although our results indicate that observer mice change their behaviour based on the movements of demonstrator mice, increases in immobility time may reflect conformity-like behaviour rather than emotional empathy. Thus, not only visual but also auditory and odour information additionally influenced the conformity-like behaviour shown by observer mice. Thus, our findings suggest that methods other than the fear observation system should be used to investigate rodent empathy-like behaviour.

DOI： 10.1186/s12868-020-00566-4

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Alpha-Pinene and Dizocilpine (MK-801) Attenuate Kindling Development and Astrocytosis in an Experimental Mouse Model of Epilepsy Reviewed International journal

Hiroshi Ueno, Atsumi Shimada, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yu Takahashi, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara

IBRO Reports 9 102 - 114 2020

Language：English Publishing type：Research paper (scientific journal)

Understanding the molecular and cellular mechanisms involved during the onset of epilepsy is crucial for elucidating the overall mechanism of epileptogenesis and therapeutic strategies. Previous studies, using a pentylenetetrazole (PTZ)-induced kindling mouse model, showed that astrocyte activation and an increase in perineuronal nets (PNNs) and extracellular matrix (ECM) molecules occurred within the hippocampus. However, the mechanisms of initiation and suppression of these changes, remain unclear. Herein, we analyzed the attenuation of astrocyte activation caused by dizocilpine (MK-801) administration, as well as the anticonvulsant effect of α-pinene on seizures and production of ECM molecules. Our results showed that MK-801 significantly reduced kindling acquisition, while α-pinene treatment prevented an increase in seizures incidences. Both MK-801 and α-pinene administration attenuated astrocyte activation by PTZ and significantly attenuated the increase in ECM molecules. Our results indicate that astrocyte activation and an increase in ECM may contribute to epileptogenesis and suggest that MK-801 and α-pinene may prevent epileptic seizures by suppressing astrocyte activation and ECM molecule production.

DOI： 10.1016/j.ibror.2020.07.007

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Pentylenetetrazol kindling induces cortical astrocytosis and increased expression of extracellular matrix molecules in mice Reviewed International journal

Ueno H, Suemitsu S, Murakami S, Kitamura N, Wani K, Takahashi Y, Matsumoto Y, Okamoto M, Ishihara T

Brain Research Bulletin 163 120 - 134 2020

Language：English Publishing type：Research paper (scientific journal)

Although epilepsy is one of the most common chronic neurological disorders with a prevalence of approximately 1.0 %, the underlying pathophysiology remains to be elucidated. Understanding the molecular and cellular mechanisms involved in the development of epilepsy is important for the development of appropriate therapeutic strategy. In this study, we investigated the effects of status epilepticus on astrocytes, microglia, and extracellular matrix (ECM) molecules in the somatosensory cortex and piriform cortex of mice. Activation of astrocytes was observed in many cortices except the retrosplenial granular cortex after pentylenetetrazol (PTZ)-induced kindling in mice. Activated astrocytes in the cortex were found in layers 1-3 but not in layers 4-6. In the somatosensory and piriform cortices, no change was observed in the number of parvalbumin (PV)-positive neurons and PV-positive neurons covered with perineuronal nets. However, the amount of ECM in the extracellular space increased. The expression of VGLUT1- and GAD67-positive synapses also increased. Thus, in the PTZ-kindling epilepsy mice model, an increase in the number of ECM molecules and activation of astrocytes were observed in the somatosensory cortex and piriform cortex. These results indicate that PTZ-induced seizures affect not only the hippocampus but also other cortical areas. Our study findings may help to develop new therapeutic approaches to prevent seizures or their sequelae.

DOI： 10.1016/j.brainresbull.2020.07.019

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Region-Specific Reduction of Parvalbumin Neurons and Behavioral Changes in Adult Mice Following Single Exposure to Cranial Irradiation Reviewed International journal

Ueno H, Suemitsu S, Murakami S, Kitamura N, Wani K, Matsumoto Y, Okamoto M, Ishihara T

International journal of radiation biology 95 ( 5 ) 611 - 625 2019.1

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: Ionizing irradiation has several long-term effects including progressive cognitive impairment. Cognitive deterioration generally appears to be caused by abnormalities in the hippocampal dentate gyrus, with abnormal function of parvalbumin-expressing interneurons (PV neurons) in the cerebral cortex. PV neurons are vulnerable to oxidative stress, which can be caused by ionizing irradiation. We speculated that selective impairment of specific brain regions due to ionizing irradiation may alter the degree of cognitive impairment. METHODS: We irradiated mature mouse brains with 20 Gy-ionizing irradiation. Subsequently, we analyzed behavioral abnormalities and changes in the number of PV neurons. RESULTS: PV neuron density was significantly lower in some cortical regions of irradiated mice than in control mice. Within 1 week of irradiation, both body weight and temperature of irradiated mice decreased. In the forced swim test, irradiated mice spent significantly less time immobile than did control mice. However, irradiated mice did not display any abnormalities in the elevated plus maze test, Y-maze test, tail suspension test, and social interaction test between 3 to 6 days after irradiation. CONCLUSIONS: These results suggest that high-dose irradiation is less likely to cause brain dysfunction in the subacute phase. Moreover, the vulnerability of PV neurons appears to be brain-region specific.

DOI： 10.1080/09553002.2019.1564081

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Layer-Specific Expression of Extracellular Matrix Molecules in the Mouse Somatosensory and Piriform Cortices Reviewed International journal

Ueno H, Suemitsu S, Murakami S, Kitamura N, Wani K, Matsumoto Y, Okamoto M, Ishihara T

IBRO Reports 6 1 - 17 2019

Language：English Publishing type：Research paper (scientific journal)

In the developing central nervous system (CNS), extracellular matrix (ECM) molecules have regulating roles such as in brain development, neural-circuit maturation, and synaptic-function control. However, excluding the perineuronal net (PNN) area, the distribution, constituent elements, and expression level of granular ECM molecules (diffuse ECM) present in the mature CNS remain unclear. Diffuse ECM molecules in the CNS share the components of PNNs and are likely functional. As cortical functions are greatly region-dependent, we hypothesized that ECM molecules would differ in distribution, expression level, and components in a region- and layer-dependent manner. We examined the layer-specific expression of several chondroitin sulfate proteoglycans (aggrecan, neurocan, and brevican), tenascin-R, Wisteria floribunda agglutinin (WFA)-positive molecules, hyaluronic acid, and link protein in the somatosensory and piriform cortices of mature mice. Furthermore, we investigated expression changes in WFA-positive molecules due to aging. In the somatosensory cortex, PNN density was particularly high at layer 4 (L4), but not all diffuse ECM molecules were highly expressed at L4 compared to the other layers. There was almost no change in tenascin-R and hyaluronic acid in any somatosensory-cortex layer. Neurocan showed high expression in L1 of the somatosensory cortex. In the piriform cortex, many ECM molecules showed higher expression in L1 than in the other layers. However, hyaluronic acid showed high expression in deep layers. Here, we clarified that ECM molecules differ in constituent elements and expression in a region- and layer-dependent manner. Region-specific expression of ECM molecules is possibly related to functions such as region-specific plasticity and vulnerability.

DOI： 10.1016/j.ibror.2018.11.006

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Feeding Behavior of Mice Under Different Food Allocation Regimens Reviewed International journal

Ueno H, Suemitsu S, Murakami S, Kitamura N, Wani K, Takahashi Y, Matsumoto Y, Okamoto M, Ishihara T

Behavioural Neurology 1581304 1 - 10 2019

Language：English Publishing type：Research paper (scientific journal)

Social interaction, a basic survival strategy for many animal species, helps maintain a social environment that has limited conflict. Social dominance has a dramatic effect on motivation. Recent evidence suggests that some primate and nonprimate species display aversive behavior toward food allocation regimens that differ from their peers. Thus, we examined the behaviors displayed by mice under different food allocation regimens. We analyzed changes in food intake using several parameters. In the same food condition, the mice received the same food; in the quality different condition, the mice received different foods; in the quantity different condition, one mouse did not receive food; and in the no food condition, none of the mice received food. To test differences based on food quality, one mouse received normal solid food as a less preferred reward, and the other received chocolate chips as a high-level reward. No behavioral change was observed in comparison to the same food condition. To test differences based on food quantity, one mouse received chocolate chips while the other received nothing. Mice who received nothing spent more time on the other side of the reward throughout the experiment. Interestingly, highly rewarded mice required more time to consume the chocolate chips. Thus, under different food allocation regimens, mice changed their behavior by being more hesitant. Moreover, mice alter food intake behavior according to the social environment. The findings help elucidate potential evolutionary aspects that help maintain social cohesion while providing insights into potential mechanisms underlying socially anxious behavior.

DOI： 10.1155/2019/1581304

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Region-Specific Reduction of Parvalbumin Neurons and Behavioral Changes in Adult Mice Following Single Exposure to Cranial Irradiation Reviewed

Ueno H, Suemitsu S, Murakami S, Kitamura N, Wani K, Matsumoto Y, Okamoto M, Ishihara T

International Journal of Radiation Biology 2 1 - 17 2019

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Papers - MATSUMOTO Yosuke