Publishing type：Research paper (scientific journal)   Publisher：Walter de Gruyter GmbH  

Abstract

Background

Apolipoprotein E (ApoE) is associated with Alzheimer’s disease (AD) and cognitive dysfunction in elderly individuals. There have been extensive studies on behavioral abnormalities in ApoE-deficient (Apoe^shl) mice, which have been described as AD mouse models. Spontaneously hyperlipidemic mice were discovered in 1999 as ApoE-deficient mice due to ApoE gene mutations. However, behavioral abnormalities in commercially available Apoe^shl mice remain unclear. Accordingly, we aimed to investigate the behavioral abnormalities of Apoe^shl mice.

Results

Apoe^shl mice showed decreased motor skill learning and increased anxiety-like behavior toward heights. Apoe^shl mice did not show abnormal behavior in the Y-maze test, open-field test, light/dark transition test, and passive avoidance test.

Conclusion

Our findings suggest the utility of Apoe^shl mice in investigating the function of ApoE in the central nervous system.

DOI： 10.1515/tnsci-2022-0284

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Other Link： https://www.degruyter.com/document/doi/10.1515/tnsci-2022-0284/pdf

Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.ibneur.2022.06.005

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1038/s41598-022-19713-4

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Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

Abstract

In mouse studies, the results of behavioural experiments are greatly affected by differences in the experimental environment and handling methods. The Porsolt forced swim test and tail suspension test are widely used to evaluate predictive models of depression-like behaviour in mice. It has not been clarified how the results of these tests are affected by testing single or multiple mice simultaneously. Therefore, this study evaluated the differences between testing two mice simultaneously or separately. To investigate the effect of testing multiple mice simultaneously, the Porsolt forced swim test and tail suspension test were performed in three patterns: (1) testing with an opaque partition between two mice, (2) testing without a partition between two mice, and (3) testing a single mouse. In the Porsolt forced swim test, the mice tested simultaneously without a partition demonstrated increased immobility time as compared to mice tested alone. No difference in immobility time was observed between the three groups in the tail suspension test. Our results showed that the environment of behavioural experiments investigating depression-like behaviour in mice can cause a difference in depression-like behaviour. The results of this experiment indicated that it is necessary to describe the method used for behavioural testing in detail.

DOI： 10.1038/s41598-022-12986-9

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Other Link： https://www.nature.com/articles/s41598-022-12986-9

Language：Japanese   Publisher：(一社)日本総合病院精神医学会  

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1155/2020/6856935.

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：De Gruyter Open Ltd  

Hexanal is a 6-carbon aldehyde that smells like green leaves and urine to mammals. However, its physiological effects remain unclear. In particular, the effects of hexanal inhalation on the central nervous system have not been clarified. We investigated hexanal inhalation in mice and conducted a series of behavioral experiments to examine the neuropsychological effects of hexanal. After inhaling hexanal emissions for 30 min, mice were subjected to an open field test, a hot plate test, a grip strength test, an elevated plus maze test, a Y-maze test, a tail suspension test, and a forced swim test to examine the effects of hexanal odor on mouse behavior. Compared to controls, mice that inhaled hexanal exhibited reduced anxiety-like behavior in the elevated plus maze test. In addition, mice that inhaled hexanal displayed significantly improved spatial cognitive ability in the Y-maze test. However, in some behavioral experiments there was no significant difference between control mice and mice that inhaled hexanal. The results of this study suggest that hexanal inhalation causes anxiolytic effects and improves cognitive function in mice. These findings may have implications for safety management procedures and determining the effective use of household goods containing hexanal, though further work is required.

DOI： 10.1515/znc-2019-0215

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Language：Japanese   Publishing type：Research paper (scientific journal)  

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DOI： 10.1080/19932820.2020.1808361

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DOI： 10.1155/2020/4071315.

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DOI： 10.1080/19932820.2020.1767275

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DOI： 10.1038/s41598-020-60530-4

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DOI： 10.1016/j.ibror.2020.07.007

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DOI： 10.1016/j.brainresbull.2020.07.019

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Language：Japanese   Publisher：(一社)日本移植学会  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：John Wiley and Sons Ltd  

Introduction: Empathic behavior is essential for social activities in social animals. Therefore, lack of empathy is a feature of several neuropsychiatric disorders. However, the underlying mechanisms of empathy and which animals possess it remain unclear. In this study, we investigated whether mice show empathic behavior. Methods: We tested mice for empathy-like behaviors toward conspecifics who were distressed. We investigated behavioral changes in cage-mate or stranger mice. Results: When the conspecific mice were in a painful state, subject mice showed preferential approach behavior toward them, presumably recognizing the state. Both visual information and olfactory information are indispensable for this empathic behavior. Conclusions: These results suggest that the mouse recognizes the emotional state of the conspecific and engages in social interaction. The results of this study are useful for the elucidation of the causal mechanisms involved in neuropsychiatric disorders and may contribute in the development of novel treatment targets.

DOI： 10.1002/brb3.986

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Language：Japanese   Publishing type：Research paper (scientific journal)  

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Kokuseido Publishing Co. Ltd  

Worldwide, most vaginoplasties in male-to-female transsexual patients utilize either a reversed penile flap or a penoscrotal flap. In cases in which the preoperative penis is short in length, neither of these methods results in adequate vaginal depth, because the proximal aspects of both penile flaps are utilized not only to construct the vaginal cavity, but also to cover the perineal area. Thus, in such cases, it is the standard to add a skin graft to resurface the depths of the vaginal cavity, although the grafted skin may constrict, resulting in a narrowed and shortened vaginal canal. Ideally, a reconstructed vagina should be fully lined with a hairless flap without a skin graft. The pudendal-thigh flap vaginoplasty was first reported by Joseph and Wee. It is commonly known that this flap contains the posterior pudendal vessels and can be elevated safely. In our pudendal groin flap vaginoplasty, we modified this flap, creating an M-shaped perineal scrotal flap and a more advanced pudendal groin flap. In doing so, this flap is adequate to line the entire cavity of the vagina, while the penile flap is only utilized to cover the perineal region and in creation of the labia minor. Recently, laparo-scopically assisted rectosigmoid colon vaginoplasty was introduced, and its utility has been documented with regard to appearance, lubrication, and sense of touch. Operative time is comparable and duration of hospitalization is less than with the conventional open method. Colon vaginoplasty as a salvage operation for complicated cases could become a first-choice protocol with the use of the laparoscope.

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Language：Japanese   Publisher：(公社)日本精神神経学会  

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Language：English   Publishing type：Research paper (scientific journal)  

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Language：Japanese   Publisher：(公社)日本精神神経学会  

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Language：Japanese   Publisher：(公社)日本精神神経学会  

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Language：Japanese   Publisher：(公社)日本精神神経学会  

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Language：English   Publishing type：Research paper (international conference proceedings)  

DOI： 10.1111/j.1528-1157.1996.tb01886.x

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1111/j.1440-1819.1994.tb03071.x

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1111/j.1440-1819.1993.tb02089.x

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Responsible for pages：pp135-151   Language：Japanese

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Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   Publisher：日本喉頭科学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J02852&link_issn=&doc_id=20230111160011&doc_link_id=10.5426%2Flarynx.34.99&url=https%3A%2F%2Fdoi.org%2F10.5426%2Flarynx.34.99&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

Language：Japanese   Publisher：(株)アークメディア  

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Language：Japanese   Publisher：(株)東京医学社  

＜Key Points＞(1)GI児へのPSは自費診療の治療であり,多職種医療チームでの診断,治療適応判定と日本精神神経医学会への報告書の提出が必要である。(2)PS前には治療に関連する副作用,身長予後やホルモン療法や性別適合手術への影響について説明を行うことが望ましい。(3)PSとともに学校での性別取り扱いの調整を行うこともGI児の社会適応改善に重要である。(著者抄録)

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J00648&link_issn=&doc_id=20221115120014&doc_link_id=%2Faq9syond%2F2022%2F005410%2F015%2F1719-1722%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Faq9syond%2F2022%2F005410%2F015%2F1719-1722%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Authorship：Lead author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   Publisher：(株)東京医学社  

＜Key Points＞(1)日本精神神経学会「性同一性障害に関する診断と治療のガイドライン」は,性別適合手術を母体保護法違反としないことを目的の一つとして策定された。(2)evidence based medicine(EBM)の体裁はとっておらず,複数診療科で包括的治療を実施するにあたっての手順書のような役割を果たしている。(3)ガイドラインに沿って実施された乳房切除術,性器に対する性別適合手術は保険診療の対象となっている。しかし,ホルモン療法は保険診療の対象となっておらず,今後の課題である。(4)現在第5版への改訂作業が進行しており,近日中に発表の予定である。(著者抄録)

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J00648&link_issn=&doc_id=20221115120006&doc_link_id=%2Faq9syond%2F2022%2F005410%2F007%2F1681-1685%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Faq9syond%2F2022%2F005410%2F007%2F1681-1685%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese   Publisher：克誠堂出版(株)  

性別違和の患者(27歳、女性から男性への性転換者)に対し、性別適合手術(gender affirming surgery:GAS)の一環として全身麻酔下に尿道延長術を施行後、PONV(術後悪心・嘔吐)の予防目的にメトクロプラミドを用い、さらに不穏の緩和目的にハロペリドールを投与した結果、錐体外路症状の急性症状であるジストニアを発症した症例について報告した。GAS希望者の全身麻酔を伴う治療では、抗精神病薬内服歴や男性ホルモン使用歴などを確認し、錐体外路症状を発症しやすい素因があることを念頭に置いて治療を行う必要があると考えられた。

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Language：Japanese   Publisher：金原出版(株)  

＜文献概要＞わが国において,性別違和をもつ人に対する包括的治療は,日本精神神経学会が公表しているガイドラインに基づいて行われている。精神科はこのなかで,診断と精神科領域の治療,身体的治療の適応に関する意見書作成といった分野での役割を担っている。性別違和感を反映する生物学的指標は存在しないため,診断はもっぱら精神医学的診察に基づくものとなる。診断過程と治療的な介入は不可分の部分があり,生活歴を聴取するなかで本人の性自認を肯定しつつ,望む性別での生活が円滑に送れるようサポートを行うという役割が精神科医に求められている。身体的治療は不可逆的な影響を残すこともあり,2名の精神科医ないし心理専門職の意見の一致が必要とされている。

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Language：Japanese   Publisher：(株)医学書院  

＜文献概要＞日本精神神経学会「性同一性障害に関する診断と治療のガイドライン」は,性別違和を持つ人に対する身体的治療を行う医療機関で標準的に使われている。策定された理由に性別適合手術の違法性を阻却することが含まれていたため,比較的厳密に運用される傾向にある。複数診療科によるチーム医療の実施を一貫して求める一方,臨床の実際や社会的な状況に応じて柔軟に改訂されてきている。2018年4月からガイドラインに沿って行われた性別適合手術は保険診療化されることになった。保険診療化にあたってGID学会認定医が医療チームの中心となることが求められており,ガイドラインに日本精神神経学会以外の学会が認定する医師について記載されるようになった。2019年に採択されたICD-11で性同一性障害はgender incongruenceと改称され精神疾患のカテゴリーから外れることになったこともあり,精神科医の役割は依然として重要であるものの,ガイドラインの策定は他の学会との共同で行うことが望ましい状況となっている。

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Language：Japanese   Publisher：日本性科学会  

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Language：Japanese   Publisher：岡山医学会  

性別違和と診断されている患者に対する看護実践は個々のコミュニケーション能力と性差観の影響を受けるという仮説を立て、「看護師の性別違和への関わりにくさについての尺度」を作成した。当院に勤務する全看護師1010人を対象にアンケート調査を実施し、556人から回答を得た。探索的因子分析により、本尺度は「関係性の構築」、「性別違和への陰性感情」の2因子から構成されることが明らかになり、尺度全体で十分な内的整合性を示した。「手術を受けてまで望む性別の身体的特徴を手に入れたいことに共感できない」とコミュニケーション・スキル尺度であるENDCOREsの二つのカテゴリーとの間に統計学的に有意で弱い負の相関が認められ、次いで「性同一性障害/性別違和は心理的錯覚だと思う」と性差観スケールとの間に統計学的に弱い正の相関が認められた。看護師の性別違和への関わりにくさと看護師個人のコミュニケーション能力・性差観との相関は限定的であることが示唆された。

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Other Link： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2022&ichushi_jid=J00175&link_issn=&doc_id=20220415230003&doc_link_id=10.4044%2Fjoma.134.22&url=https%3A%2F%2Fdoi.org%2F10.4044%2Fjoma.134.22&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Language：Japanese   Publisher：医歯薬出版(株)  

日本精神神経学会の「性同一性障害に関する診断と治療のガイドライン」は広く知られており、主要な治療施設ではこのガイドラインに沿って診療が行われている。ガイドラインによる診療は精神科医の関与のもと、複数診療科が包括的な治療を実施するものとなっている。とくに身体的な治療を行うためには、医療チームによる会議を開く必要がある。記載されている身体的治療は、思春期の患者を対象とした二次性徴抑制療法、ホルモン療法と乳房切除、性別適合手術である。2016年に、GID(性同一性障害)学会は認定医制度をスタートさせた。2021年からは心理専門職、看護・助産師、法曹関係者、教員などを対象とした認定コーディネーター制度が追加された。これらはどのような人が性別違和をもつ人の治療や援助に携わるべきかを示す1つの基準である。2018年からガイドラインに沿ってGID学会認定医が認定施設で実施した乳房切除術、性器に対する性別適合手術は保険診療の適応を受けている。(著者抄録)

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Language：Japanese   Publisher：(一社)日本心身医学会  

LGBTQ+と呼ばれるセクシュアルマイノリティのメンタルヘルスは損なわれやすいことがさまざまな研究で明らかになっている。筆者は主にトランスジェンダーの生活史を多数聴取しているが、メンタルヘルスの問題はLGBTQ+に共通するものがあると考えている。それは社会との間で抱える問題であり、LGBTQ+本人の中にはない。学校における種々のジェンダーの規範はトランスジェンダーを苦しめる。学校教育などの中でセクシュアリティの多様性に関して肯定的な情報の提供は乏しい一方、LBGTQ+を揶揄するような否定的な情報はさまざまな場面で繰り返され、それが問題であることもほとんど指摘されることはない。LGBTQ+の割合は20〜30人に1人とされ、医療機関受診者にも多数混じっている。彼らのメンタルヘルスを守るためには、医療者が無自覚にもっているスティグマに気づく必要がある。(著者抄録)

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2021&ichushi_jid=J00677&link_issn=&doc_id=20211005120001&doc_link_id=10.15064%2Fjjpm.61.7_599&url=https%3A%2F%2Fdoi.org%2F10.15064%2Fjjpm.61.7_599&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Language：Japanese   Publisher：(公社)日本精神神経学会  

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Language：Japanese   Publisher：(一社)日本総合病院精神医学会  

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Language：Japanese   Publisher：(一社)日本児童青年精神医学会  

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Language：Japanese   Publisher：(一社)日本児童青年精神医学会  

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Language：Japanese   Publisher：(公社)日本精神神経学会  

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Language：Japanese   Publisher：(株)アークメディア  

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Language：Japanese   Publisher：(株)医学書院  

＜文献概要＞ガイドラインのポイント ・性別違和を訴える者に対する診断と治療のガイドラインである。・1997年に初版が発行された。初版から精神科,産婦人科,泌尿器科,形成外科などの複数診療科が医療チームを結成して行う包括的な治療について記載されている。・エビデンスに基づく治療法の推奨というより,性別違和を持つ当事者に対して法的,倫理的に妥当な医療のあり方を提示しているものである。また,身体的治療を行う際の診療科間の連携手順書のような役割を持つ。・初版から精神科的な診断と治療のアプローチに加えて,ホルモン療法,乳房切除術,性別適合手術について記載されていたが,2012年に改訂された第4版では思春期を迎えた小児への身体的治療である二次性徴抑制療法が追加され,18歳からとされていたホルモン療法開始年齢を一部引き下げた。2018年4月から,このガイドラインに沿ってGID学会の認定施設で行われた手術は保険診療の対象となっている。

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Language：Japanese   Publisher：GID(性同一性障害)学会  

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Language：Japanese   Publisher：(NPO)全国大学メンタルヘルス学会  

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Language：Japanese  

J-GLOBAL

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Language：Japanese  

J-GLOBAL

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Language：English   Publisher：PERGAMON-ELSEVIER SCIENCE LTD  

Many neuropsychiatric disorders show localized dysfunction in specific cortical regions. The mechanisms underlying such region-specific vulnerabilities are unknown. Post-mortem analyses have demonstrated a selective reduction in the expression of parvalbumin (PV) in GABAergic interneurons in the frontal rather than the sensory cortex of patients with neuropsychiatric disorders such as schizophrenia, autism spectrum disorders, and bipolar disorders. PV neurons are surrounded by perineuronal nets (PNNs), and are protected from oxidative stress. Previous studies have shown that the characteristics of PNNs are brain region-specific. Therefore, we hypothesized that PV neurons and PNNs may be targeted in region-specific lesions in the brain. Oxidative stress was induced in mice by rearing them in socially isolated conditions. We systemically examined the distribution of PV neurons and PNNs in the brains of these mice as well as a control group. Our results show that the regions frequently affected in neuropsychiatric disorders show significantly lower PV expression and a lower percentage of PV neurons surrounded by PNNs in the brains of socially isolated mice. These results indicate that PV neurons and PNNs exhibit region-specific vulnerabilities. Our findings may be useful for elucidating the mechanisms underlying region-specific disruption of the brain in neuropsychiatric disorders. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.neuroscience.2017.07.016

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Perineuronal nets (PNNs) are structures of extra cellular matrix molecules surrounding the cell bodies and proximal dendrites of certain neurons. While PNNs are present throughout the mouse cerebral cortex, recent studies have shown that the components differ among cortical sub-regions and layers, suggesting region-specific functions. Parvalbumin-expressing interneurons (PV neurons) may be important regulators of cortical plasticity during the early "critical period" that is sensitive to sensory input. Here we examined the distribution and developmental functions of PNN components associated with PV neurons in the somatosensory cortex during the critical period. Aggrecan, brevican, neurocan, phosphacan, and tenascin-R were identified as PNN components in the mouse somatosensory cortex. High-magnification analysis revealed that some lectin Wisteria floribunda agglutinin (WFA)-reactive molecules did not co-localize with monoclonal antibody Cat-315 recognition molecules around the cell body. During postnatal development, Cat-315-positive (Cat-315(+)) PNNs appeared later than PNNs binding to the lectin WFA (WFA(+) PNNs). These WFA(+) PNNs changed from granular-like to reticular like structures during normal cortical development, while this transition was delayed by sensory deprivation. This study indicates that the formation of reticular-like WFA(+) PNNs is dependent on sensory experience in the mouse somatosensory cortex. We suggest that Cat-315(+) molecules and WFA expression in PNNs are involved in the early critical period of input-dependent cortical plasticity. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.neuroscience.2017.04.041

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Authorship：Lead author   Language：English   Publisher：PERGAMON-ELSEVIER SCIENCE LTD  

The prefrontal cortex (PFC) plays a key role in cognitive functions, memory, and attention. Alterations in parvalbumin interneurons (PV neurons) and perineuronal nets (PNNs) within the PFC have been implicated in schizophrenia and autism spectrum disorder pathology. However, it remains unclear why PV neurons and PNNs in the PFC are selectively impaired. Here we aimed to clarify if PV neurons and PNNs in the PFC have region-specific features. We found that PV neurons and PNNs were increased in a region-specific manner in the PFC during postnatal development. In the mature PFC, the expression of PV protein is lower than in other parts of the cortex. Furthermore, PNNs in the mature PFC are not typical lattice-like structures and do not have the major components of PNNs and tenascin-R. The present study indicates that PV neurons and PNNs have region-specific features, and our results suggest that PV neurons and PNNs have structural vulnerability within the PFC. (C) 2016 IBRO. Published by Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.neuroscience.2016.11.035

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Other Link： http://search.jamas.or.jp/link/ui/2016076180

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Other Link： http://search.jamas.or.jp/link/ui/2016374645

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Language：Japanese   Publisher：日本評論社  

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Other Link： http://search.jamas.or.jp/link/ui/2016399132

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Early loss of one sensory system can cause improved function of other sensory systems. However, both the time course and neuronal mechanism of cross-modal plasticity remain elusive. Recent study using functional MRI in humans suggests a role of the prefrontal cortex (PFC) in cross-modal plasticity. Since this phenomenon is assumed to be associated with altered GABAergic inhibition in the PFC, we have tested the hypothesis that early postnatal sensory deprivation causes the changes of inhibitory neuronal circuit in different regions of the PFC of the mice. We determined the effects of sensory deprivation from birth to postnatal day 28 (P28) or P58 on the density of parvalbumin (PV), calbindin (CB), and calretinin (CR) neurons in the prelimbic, infralimbic, and dorsal anterior cingulate cortices. The density of PV and CB neurons was significantly increased in layer 5/6 (L5/6). Moreover, the density of CR neurons was higher in L2/3 in sensory deprived mice compared to intact mice. These changes were more prominent at P56 than at P28. These results suggest that long-term sensory deprivation causes the changes of intracortical inhibitory networks in the PFC and the changes of inhibitory networks in the PFC may contribute to cross-modal plasticity.

DOI： 10.1155/2015/753179

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Language：Japanese   Publisher：金原出版  

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Other Link： http://search.jamas.or.jp/link/ui/2014106775

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Other Link： http://search.jamas.or.jp/link/ui/2013260383

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Language：Japanese   Publisher：日本児童青年精神医学会  

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Other Link： http://search.jamas.or.jp/link/ui/2014141467

Language：English   Publisher：ELSEVIER IRELAND LTD  

Persons with gender identity disorder (GID) often suffer from psychiatric co-morbidity, and it is an important prognostic factor for long-term psychosocial adjustment in GID. However, previous research has not addressed the risk factors of psychiatric co-morbidity. In this study, we tried to clarify the risk factors among individuals with GID in Japan. A total of 326 consecutive GID persons were evaluated independently by two senior psychiatrists at the GID clinic using personal clinical interviews and results of examinations. The prevalence of current psychiatric co-morbidity was 17.8% of the total sample. School refusal was significantly associated with psychiatric co-morbidity. Sexual attraction to neither males nor females among GID persons and sexual attraction to females among male-to-female (MtF) GID persons were also significantly related to psychiatric co-morbidity. This is the first report to demonstrate a close relationship between patterns of sexual orientation and psychiatric co-morbidity among GID persons. We should pay more attention to psychiatric co-morbidity, especially among GID persons with non-homosexual sexual orientations. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.psychres.2012.07.018

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Objective: The accumulating evidence suggests that school refusal behavior is associated with severe negative outcomes. However, previous research has not addressed school refusal by patients with gender identity disorder (GID). In this study, we tried to clarify the prevalence of school refusal among GID patients and the relationship of school refusal to demographic characteristics.
Methods: A total of 579 consecutive Japanese GID patients at the outpatient GID Clinic of Okayama University Hospital between April 1997 and October 2005 were evaluated.
Results: The prevalence of school refusal was 29.2% of the total sample. School refusal was more frequent among GID patients with divorced parents than those with intact families. Multiple logistic regression analysis showed that younger age at consultation and divorce of parents were significantly associated with school refusal among the male-to-female GID patients.
Conclusion: The rate of school refusal among GID patients is high, and school refusal is closely related with a low level of education and current unemployment. We should pay more attention to GID patients of school age to prevent their school refusal, which results in low educational achievement. (C) 2012 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.genhosppsych.2011.11.008

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Language：English   Publisher：OKAYAMA UNIV MED SCHOOL  

Recent studies have demonstrated the important role of immune molecules in the development of neuronal circuitry and synaptic plasticity. We have detected the presence of Fc gamma RIIB protein in parvalbumin-containing inhibitory interneurons (PV neurons). In the present study, we examined the appearance of PV neurons in the barrel cortex and the effect of sensory deprivation in Fc gamma RIIB-deficient mice (Fc gamma RIIB-/-) and wild-type mice. There was no substantial difference in the appearance of PV neurons in the developing barrel cortex between Fc gamma RIIB-/- and wild-type mice. Sensory deprivation from immediately after birth (PO) or P7 to P12-P14 induced an increase in PV neurons. In contrast, sensory deprivation from P7 or P14 to P28, but not from P21 to P28, decreased PV neurons in wild-type mice. However, sensory deprivation from PO or P7 to P12-P14 did not increase PV neurons and sensory deprivation from P7 or P14 to P28 did not decrease or only modestly decreased PV neurons in Fc gamma RIIB-/- mice. The results indicate that expression of PV is regulated by sensory experience and the second and third postnatal weeks are a sensitive period for sensory deprivation, and suggest that Fc gamma RIIB contributes to sensory experience-regulated expression of PV.

DOI： 10.18926/AMO/48264

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Language：Japanese   Publisher：(公社)日本精神神経学会  

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Other Link： https://projects.repo.nii.ac.jp/?action=repository_uri&item_id=449596

Language：Japanese   Publisher：(一社)日本移植学会  

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In this study, we tried to clarify the prevalence of suicidal ideation and self-mutilation including suicide attempts among patients with gender identity disorder (GID) and the relationship of those behaviors to demographic characteristics. A total of 500 consecutive Japanese GID patients without any other psychiatric comorbidity were evaluated at the outpatient GID Clinic of Okayama University Hospital. The lifetime rate of suicidal ideation was 72.0% of the total sample. There were no significant differences in the prevalence of suicidal ideation among groups divided by sex, age, age at onset or education. The lifetime prevalence of self-mutilation including suicide attempts was 31.8% of the total sample. Low level of education was significantly related to self-mutilation among both male-to-female and female-to-male GID patients. Younger age at onset was a significant factor affecting self-mutilation only among MTF GID patients. A lack of strategies to cope with severe distress among persons with lower education might induce a high frequency of self-mutilation including suicidal attempt. GID patients with a low level education might be at high risk of self-mutilation and should be watched with special attention to self-mutilation. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.psychres.2011.04.024

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Language：Japanese   Publisher：GID(性同一性障害)学会  

高知県内の55の精神科・心療内科施設に所属する医師に、性同一性障害を疑う受診者に対する対応状況や、過去10年間での受診者数などについて自記式調査票を用い調査した。高知県近隣の専門施設にも、高知県在住の受診者数について問い合わせた。県内の30施設と51人(重複回答を除くと46人)の医師、県外の6施設から回答を得た。過去10年間における高知県内の精神科・心療内科への性同一性障害が疑われる患者ののべ受診者数はおよそ40名であった。県外施設での高知県からの患者の受診者数は60人であった。県内医師の対応状況は「県外他院を紹介」がもっとも多く、「自院で精神療法」は、ほぼなかった。高知県内に患者は相当数いるが、診療施設が不足しており、越境受診をしていることが明らかになった。

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DOI： 10.11477/mf.1405101941

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Other Link： http://search.jamas.or.jp/link/ui/2011339611

DOI： 10.11477/mf.1413102540

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Language：English   Publisher：WILEY-BLACKWELL  

Aims:
Psychiatric comorbidity and mental instability seem to be important unfavorable prognostic factors for long-term psychosocial adjustment in gender identity disorder (GID). However, psychiatric comorbidity in patients with GID has rarely been assessed. In this study, we investigated the psychiatric comorbidity and life events of patients with GID in Japan.
Methods:
A total of 603 consecutive patients were evaluated independently by at least two senior psychiatrists at the GID clinic using clinical information and results of examinations.
Results:
Using DSM-IV criteria, 579 patients (96.0%) were diagnosed with GID. Among the GID patients, 349 (60.3%) were the female-to-male (FTM) type, and 230 (39.7%) were the male-to-female (MTF) type. Current psychiatric comorbidity was 19.1% (44/230) among MTF patients and 12.0% (42/349) among FTM patients. The lifetime positive history of suicidal ideation and self mutilation was 76.1% and 31.7% among MTF patients, and 71.9% and 32.7% among FTM patients. Among current psychiatric diagnoses, adjustment disorder (6.7%, 38/579) and anxiety disorder (3.6%, 21/579) were relatively frequent. Mood disorder was the third most frequent (1.4%, 8/579).
Conclusions:
Comparison with previous reports on the psychiatric comorbidity among GID patients revealed that the majority of GID patients had no psychiatric comorbidity. GID is a diagnostic entity in its own right, not necessarily associated with severe comorbid psychological findings.

DOI： 10.1111/j.1440-1819.2010.02118.x

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Language：Japanese   Publisher：(公社)日本精神神経学会  

性同一性障害495例を対象に、日本語版ストレスコーピングインベントリー(SCI)により、ストレスコーピング戦略について検討した。その結果、FTM(female to male)群で肯定評価型と隔離型のスコアが、MTF(male to female)群に比べて高かった。年齢別では、25〜29歳のグループで隔離型のスコアが、24歳以下および35歳以上に比べて有意に高く、30〜34歳のグループに比べても高い傾向があった。その他のストレスコーピングのスコアに差異はなかった。当ジェンダークリニックの受診者は20歳代のFTM患者の割合が突出しており、その多くは最初から性別適合手術を受けたいという明確な意思をもって来院している。FTM患者で肯定評価型のコーピング戦略が多く見られたのは、特定の受診行動患者が集まったことかもしれないと考えられた。

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DOI： 10.1016/j.neuroscience.2010.01.004

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Language：English   Publishing type：Book review, literature introduction, etc.   Publisher：PERGAMON-ELSEVIER SCIENCE LTD  

To investigate the biological mechanism of gender identity disorder (GID), five candidate sex hormone-related genes, encoding androgen receptor (AR), estrogen receptors alpha (ER alpha) and beta (ER beta), aromatase (CYP19), and progesterone receptor (PGR) were analyzed by a case-control association study. Subjects were 242 transsexuals (74 male-to-female patients (MTF) and 168 female-to-male patients (FTM)), and 275 healthy age- and geographical origin-matched controls (106 males and 169 females). The distributions of CAG repeat numbers in exon 1 of AR, TA repeat numbers in the promoter region of ER alpha CA repeat numbers in intron 5 of ER beta, TTTA repeat numbers in intron 4 of CYP19, and six polymorphisms (rs2008112, rs508653, V660L, H770H, rs572698 and PROGINS) of PGR were analyzed. No significant difference in allelic or genotypic distribution of any gene examined was found between MTFs and control males or between FTMs and control females. The present findings do not provide any evidence that genetic variants of sex hormone-related genes confer individual susceptibility to MTF or FTM transsexualism. (C) 2009 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.pnpbp.2009.07.008

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Language：English   Publishing type：Book review, literature introduction, etc.   Publisher：PERGAMON-ELSEVIER SCIENCE LTD  

To investigate the biological mechanism of gender identity disorder (GID), five candidate sex hormone-related genes, encoding androgen receptor (AR), estrogen receptors alpha (ER alpha) and beta (ER beta), aromatase (CYP19), and progesterone receptor (PGR) were analyzed by a case-control association study. Subjects were 242 transsexuals (74 male-to-female patients (MTF) and 168 female-to-male patients (FTM)), and 275 healthy age- and geographical origin-matched controls (106 males and 169 females). The distributions of CAG repeat numbers in exon 1 of AR, TA repeat numbers in the promoter region of ER alpha CA repeat numbers in intron 5 of ER beta, TTTA repeat numbers in intron 4 of CYP19, and six polymorphisms (rs2008112, rs508653, V660L, H770H, rs572698 and PROGINS) of PGR were analyzed. No significant difference in allelic or genotypic distribution of any gene examined was found between MTFs and control males or between FTMs and control females. The present findings do not provide any evidence that genetic variants of sex hormone-related genes confer individual susceptibility to MTF or FTM transsexualism. (C) 2009 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.pnpbp.2009.07.008

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Language：English   Publisher：WILEY-BLACKWELL PUBLISHING, INC  

Aims:
Previous research has not addressed gender differences in coping strategies among patients with gender identity disorder (GID). Nor has the relationship of coping strategies to other demographic characteristics ever been clarified in GID. In this study, we tried to clarify the relationship between stress-coping strategies and demographic characteristics among patients with GID.
Methods:
The coping strategies of 344 patients with GID [227 female-to-male (FTM) and 117 male-to-female (MTF)] were assessed using the Japanese version of the Ways of Coping Questionnaires, Lazarus Stress-coping Inventory.
Results:
Comparison of the stress-coping inventory between MTF and FTM GID patients revealed that FTM GID patients were significantly more reliant on positive reappraisal strategies in stressful situations than MTF GID patients (P = 0.007).
Conclusions:
The difference in the usage of positive reappraisal strategies between MTF and FTM type GID patients was not explained by other demographic characteristics, and we suppose that the gender difference in GID patients might influence the usage of positive reappraisal strategies. The ratio of FTM GID patients might be higher at our center because MTF GID patients can obtain vaginoplasty easily, whereas phalloplasty surgery for FTM GID patients is performed at only a few centers, including our clinic, in Japan. As a result, more FTM GID patients come to our clinic with a clear intention to undergo sexual rearrangement surgery, which might influence the gender difference in using positive reappraisal.

DOI： 10.1111/j.1440-1819.2009.02017.x

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Language：English   Publisher：ELSEVIER IRELAND LTD  

The aim of this study was to examine the clinical characteristics of patients with gender identity disorder (GID) at a GID clinic in Japan. A total of 603 consecutive patients were evaluated at the GID clinic using clinical information and results of physical and neurological examinations. Using DSM-IV criteria, 579 patients (96.0%) were diagnosed with GID. Four patients were excluded for transvestic fetishism, eight for homosexuality, five for schizophrenia, three for personality disorders, and four for other psychiatric disorders. Among the GID patients, 349 (60.3%) were the female-to-male (FTM) type, and 230 (39.7%) were the male-to-female (MTF) type. Almost all FTM-type GID patients started to feel discomfort with their sex before puberty and were sexually attracted to females. The proportion of FTM patients who had experienced marriage as a female was very low, and very few had children. Therefore, FTM-type GID patients seem to be highly homogeneous. On the other hand, various patterns of age at onset and sexual attraction existed among MTF patients. Among the MTF-type GID patients, 28.3% had married as males and 18.7% had sired children. Thus, MTF-type GID patients seem to be more heterogeneous. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.psychres.2007.07.022

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Language：Japanese   Publisher：Japan Epilepsy Society  

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We examined antiepileptogenic and anticonvulsant effects of [2,3-dioxo-7-(1H-imidazol-1-yl)-6-niti-o-1,2,3,4-tetrahydro-1-quinoxalinyl]-acetic acid monohydrate (YM872), a potent and highly water-soluble alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor antagonist, in the rat amygdala kindling model of epilepsy. Administration of YM872 significantly suppressed fully kindled seizures. Daily pretreatment with YM872 markedly retarded development of kindling during drug sessions. We also used the rekindling method to investigate the antiepileptogenic effect of YM872 in an attempt to differentiate between true and false effects in the conventional method of daily administration. The results using the rekindling method suggested that the effect of YMS72 was truly antiepileptogenic, indicating its possible clinical usefulness as an antiepileptogenic drug. We also affirmed the importance of AMPA receptors in the seizure expression mechanism and development of kindling-induced epileptogenesis. (c) 2005 Elsevier B.V. All rights reserved.

DOI： 10.1016/j.ejphar.2005.11.044

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The aim of the present study was to determine the change of serum uric acid (UA) levels in male adolescents and to characterize the relationship between UA levels and obesity or its related factors. This study was conducted in 17,155 students at enrollment in Okayama University from 1991 through 2002, in which the mean serum UA level as a whole was 5.64 +/- 0.009 mg/dL (mean +/- SEM) and the incidence of hyperuricemia (greater than or equal to7.6 mg/dL) was 4.13%. Serum UA levels were correlated with obesity-related indicators, including body mass index (BMI; r = 0.282, P < .0001) and skin-fold thickness (r = 0.286, P < .0001). The incidence of hyperuricemia was increased in parallel with BMI. In the last 4 years (1999 through 2002) of the study period, serum UA levels (5.76 mg/dL) and the incidence of hyperuricemia (4.5%) were significantly increased compared with those in the earlier period (1991 through 1994: 5.50 mg/dL and 3.5%, respectively). However, BMI has been rather gradually decreased throughout 12-year observation in all the subjects. Hyperuricemia was related to the presence of other risk factors, including hypercholesterolemia, liver function abnormality, and hypertension. The frequencies of such abnormalities were higher than euuricemic subjects and this trend was notable in the most recent students enrolled from 1999 through 2002. Hyperuricemia was even found in the group of non-obese male adolescents. Taking into consideration that hyperuricemia is associated with a high prevalence of lifestyle-related diseases in adults, it is of great importance to prevent hyperuricemia at the early stage in Japanese adolescents. (C) 2004 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.metabol.2003.11.017

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Language：English   Publishing type：Research paper, summary (international conference)   Publisher：BLACKWELL PUBLISHING INC  

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Language：English   Publishing type：Research paper, summary (international conference)   Publisher：BLACKWELL PUBLISHING INC  

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The perirhinal cortex (PRC) has recently been reported that the excitatory role of this area is important for the generation and the propagation of kindled seizures. In the present study, we investigated the extracellular electrophysiological properties of the circuitry which contribute to the propagation of seizures in the PRC, and examined the hypothesis that amygdala-kindling changes the electrophysiological nature of the rat PRC slice in vitro. Field potentials elicited in the PRC had extended duration (&gt
200 ms, most ≃ 1 s) with overlying spike components. The potentials showed strong synchronizing effect governed by an all-or-none rule. Although spontaneous epileptiform discharges that were equivalent in appearance to synaptically-activated field potentials were observed in the PRC of both amygdala-kindled and control rats, the number of slices showing spontaneous activity was significantly larger in the kindled group than in the control group (χ2-test, P &lt
0.01). The occurrence of tetanus-induced afterdischarges in kindled rats was significantly higher than in control rats (χ2-test, P &lt
0.01). The afterdischarge durations of control slices were generally short and the afterdischarges did not consist of the typical 'tonic-clonic' phases. However, the occurrence of the electrographical seizure in the high K+ ACSF were not affected by amygdala-kindling operation. These results indicate that amygdala-kindling lowers the threshold for transsynaptic excitability and enhances the synchronized activity of the PRC induced by episodic proconvulsive manipulations such as tetanus stimulation.

DOI： 10.1016/S0006-8993(96)00878-5

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A comparative study of the anticonvulsant effect of GABA agonists on amygdala or hippocampal kindled seizures was performed in cats. Progabide (GABA receptor agonist, 25-100mg/kg) significantly reduced both the kindled seizure stage and afterdischarge (AD) duration in a dose-dependent manner. SKF89976A (GABA re-uptake inhibitor, 0.25-2mg/kg) also significantly reduced kindled seizures. At a toxic dose of SKF89976A, induction of the AD in the kindled focus was completely suppressed, although it caused EEG spike and myoclonus. Furthermore, γ-vinyl GABA (GVG: inhibitor of GABA transaminase, 50-200mg/kg) significantly reduced only the kindled seizure stage with the prolonged duration of ADs. In contrast, baclofen (selective GABA-B receptor agonist, 1 and 5mg/kg) did not show any anticonvulsant effects either on the seizure stage or on the AD duration. It is concluded that these GABA agonists, which potentiate the inhibitory function of the GABA-A system, have potent anticonvulsant effects on kindled seizures from the lymbic focus as well as secondary generalization in cats.

DOI： 10.3805/jjes.10.268

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Event date： 2024.2.10

Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Event date： 2023.12.18

Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Event date： 2023.11.17

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

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Event date： 2023.11.8

Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Event date： 2023.11.4

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

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Event date： 2023.10.8

Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Event date： 2023.9.28

Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Event date： 2023.8.31

Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Event date： 2023.7.29 - 2023.7.30

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

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Event date： 2023.4.9

Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Event date： 2023.3.25 - 2023.3.26

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

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Event date： 2023.2.11

Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Event date： 2022.5.29

Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

Event date： 2022.3.10 - 2022.3.11

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Event date： 2021.9.19 - 2021.9.21

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

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Event date： 2021.7.4

Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Event date： 2021.4.3

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

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Event date： 2020.10.25

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

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Event date： 2020.10.22 - 2020.10.24

Language：Japanese   Presentation type：Oral presentation (invited, special)  

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Event date： 2020.9.28 - 2020.9.30

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

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Event date： 2019.12.5 - 2019.12.7

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：沖縄  

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Event date： 2019.11.21 - 2019.11.22

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：松江  

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Event date： 2019.11.21 - 2019.11.22

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：松江  

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Event date： 2019.10.31 - 2019.11.2

Language：Japanese   Presentation type：Poster presentation  

Venue：神戸  

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Event date： 2019.10.5

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：鹿児島  

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Event date： 2019.9.7

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Venue：岡山  

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Event date： 2019.6.20 - 2019.6.22

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Venue：新潟  

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Event date： 2019.6.20 - 2019.6.22

Language：Japanese   Presentation type：Poster presentation  

Venue：新潟  

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Event date： 2019.3.23

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：岡山  

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Event date： 2019.2.16

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：下関  

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Event date： 2018.12.6 - 2018.12.7

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：岡山  

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Event date： 2018.9.14

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Venue：神戸  

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Event date： 2018.3.24 - 2018.3.25

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Venue：東京  

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Event date： 2018.3.24 - 2018.3.25

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：東京  

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Event date： 2018.2.17

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：高松  

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Event date： 2017.11.17 - 2017.11.18

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Venue：富山  

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Event date： 2017.6.29

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：岡山  

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Event date： 2017.6.10

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：岡山  

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Event date： 2017.3.18 - 2017.3.19

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：札幌  

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Event date： 2016.12.1

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：岡山  

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Event date： 2016.10.27 - 2016.10.29

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：岡山  

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Event date： 2016.6.4

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Venue：千葉  

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Event date： 2016.3.20

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Venue：東京  

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Event date： 2016.2.13

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：岡山  

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Event date： 2015.11.14

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：広島  

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Event date： 2015.3.3 - 2015.3.6

Language：English   Presentation type：Symposium, workshop panel (public)  

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Event date： 2014.10.11 - 2014.10.12

Language：Japanese   Presentation type：Symposium, workshop panel (public)  

Venue：岡山  

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Event date： 2014.6.26 - 2014.6.28

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：横浜  

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Event date： 2014.6.26 - 2014.6.28

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Venue：横浜  

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Event date： 2014.2.14 - 2014.2.18

Language：English   Presentation type：Symposium, workshop panel (nominated)  

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Event date： 2013.11.29 - 2013.11.30

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Venue：京都  

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Event date： 2013.10.10 - 2013.10.12

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Venue：札幌  

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Event date： 2013.6.13

Language：Japanese   Presentation type：Poster presentation  

Venue：岡山  

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Event date： 2013.5.23 - 2013.5.25

Language：Japanese   Presentation type：Symposium, workshop panel (public)  

Venue：福岡  

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Event date： 2013.5.23 - 2013.5.25

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Venue：福岡  

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Event date： 2012.11.30 - 2012.12.1

Language：Japanese   Presentation type：Poster presentation  

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Event date： 2012.11.30 - 2012.12.1

Language：Japanese   Presentation type：Poster presentation  

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Event date： 2012.11.15 - 2012.11.16

Language：Japanese   Presentation type：Oral presentation (general)  

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Event date： 2012.10.31 - 2012.11.2

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Venue：東京  

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Event date： 2012.10.31 - 2012.11.2

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Venue：東京  

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Event date： 2012.9.27 - 2012.9.29

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Venue：岡山  

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Event date： 2012.9.7 - 2012.9.9

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：北海道  

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Event date： 2012.8.2 - 2012.8.5

Language：English   Presentation type：Oral presentation (general)  

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Event date： 2012.6.28

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：岡山  

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Event date： 2012.6.9

Language：Japanese  

Venue：岡山  

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Event date： 2012.5.24 - 2012.5.26

Language：Japanese   Presentation type：Poster presentation  

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Event date： 2012.4.13 - 2012.4.15

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Venue：兵庫  

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Event date： 2012.3.17 - 2012.3.18

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：岡山  

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Event date： 2012.3.17 - 2012.3.18

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：岡山  

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Event date： 2011.9.20 - 2011.9.22

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：名古屋市  

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Event date： 2011.8.25

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：岡山大学五十周年記念館  

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Event date： 2011.7.22 - 2011.7.23

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：仙台市  

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Event date： 2011.6.23

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：岡山  

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Event date： 2010.11.20 - 2010.11.21

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：岡山市三木記念ホール  

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Event date： 2010.10.16 - 2010.10.17

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：倉敷市  

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Event date： 2010.10.14 - 2010.10.15

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：岡山  

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Event date： 2010.2.20

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：岡山市  

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Event date： 2009.11

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：松江  

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Event date： 2009.8.21 - 2009.8.23

Language：Japanese   Presentation type：Poster presentation  

Venue：神戸  

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Event date： 2009.8.21 - 2009.8.23

Language：Japanese   Presentation type：Poster presentation  

Venue：神戸  

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Event date： 2008.11.22

Presentation type：Oral presentation (general)  

Venue：徳島市  

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Event date： 2008.6.14

Presentation type：Oral presentation (general)  

Venue：岡山市  

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Event date： 2008.3.16

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Venue：高槻市  

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Event date： 2005.11.10

Venue：岡山市  

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Event date： 2003.10.1 - 2003.10.2

Venue：金沢  

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Event date： 2003.10

Venue：Lisbon  

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Event date： 2003.10

Venue：Lisbon  

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Event date： 2003.8.28 - 2003.8.29

Venue：松山  

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Event date： 2002.9.12 - 2002.9.13

Venue：軽井沢  

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Event date： 2001.11.25

Venue：福山  

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Event date： 2001.11.19

Venue：倉敷  

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Event date： 2001.10.2

Venue：岡山  

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Event date： 2001.9.28

Venue：東京  

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Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

Venue：岡山市（WEB配信）  

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Type：Lecture

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Audience： Teachers

Type：Lecture

Audience： Teachers

Type：Lecture

Audience： Teachers

Type：Lecture

Audience： Teachers

Type：Lecture