研究者詳細 - 早川　聡

MISC - 早川　聡

分割表示 161 件中 61 - 80 件目／全件表示 >>

Formation of nano- and micrometer-scale hydroxyapatite rod array structure on ca-containing glass

Satoshi Hayakawa, Hiroshi Kazama, Kanji Tsuru, Akiyoshi Osaka, Eiji Fujii, Koji Kawabata

8th World Biomaterials Congress 2008 1 134 2008年12月

Solid state NMR highlights local structures of OXO-anions in hydroxyapatite lattice

A. Osaka, S. Hayakawa, K. Tsuru, T. Kanaya, E. Fujii, K. Kawabata, G. Gasqueres, C. Bonhomme, F. Babonneau, C. Jäger

A Global Road Map for Ceramic Materials and Technologies: Forecasting the Future of Ceramics, International Ceramic Federation - 2nd International Congress on Ceramics, ICC 2008, Final Programme 2008年12月

Carbonate- and Si-involving hydroxyapatite (C-HA, Si-HA) as well as hydroxyapatite (HAp) was prepared through wet chemical processes. Magic angle Spinning (MAS) NMR spectroscopy was applied together with Cross-Polarization (CP) techniques to study chemical environments around the guest oxo-anions. C-HA involved at least four carbonate sites, but the one for ∼168 ppm was left unassigned. In Si-HA, only Q0 (SiO44-) replaced the phosphate ion site but other Si atoms were polymerized and present on the surface or in the grain boundary of the Si-HA particles. The 31P MAS and CP-MAS spectra indicated the absence of HPO42- in the lattice, and suggested the presence of an amorphous phosphate phase on the particle surface.

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Si-eluting gelatin -silicate hybrid scaffolds inspired by bioactive glasses

K. Tsuru, Z. Robertson, B. Annaz, I. R. Gibson, S. M. Best, Y. Shirosaki, S. Hayakawa, A. Osaka

8th World Biomaterials Congress 2008 1 305 2008年12月

骨伝導性の向上を目的としたチタン系インプラント表面の空間デザイン

都留寛治, 杉野篤史, 早川聡, 大槻主税, 石川邦夫, 尾坂明義

歯科材料・器械 27 ( 5 ) 341 - 341 2008年9月

Gap effect on the heterogeneous nucleation of apatite on thermally oxidized titanium substrate

Atsushi Sugino, Keita Jetsuki, Kanji Tsuru, Satoshi Hayakawa, Chikara Ohtsuki, Akiyoshi Osaka

BIOCERAMICS, VOL 20, PTS 1 AND 2 361-363 621 - + 2008年

記述言語：英語出版者・発行元：TRANS TECH PUBLICATIONS LTD

Apatite formation on the surface of materials in body environment is an essential condition to show osteoconduction after implantation in bony defects. This study reports the novel technique for providing the apatite-forming ability to titanium metals by only controlling the spatial gap and thermal oxidation. Two pieces of titanium thermally oxidized at 400 degrees C were set together like Wetter with varied mouth opening. They showed the formation of apatite on both facing surface after exposure to a simulated body fluid (SBF) proposed by Kokubo and his colleagues, when the gap was less than approximately 600 mu m. Moreover, specimens with micro-grooves of 500 mu m in depth and 200-1000 mu m in width was able to form apatite in SBF with in 7 days, after they were thermally oxidized at 400 degrees C. These results indicated that the titanium metals were provided with apatite-forming ability, i.e. osteoconduction, due to controlled gap with thermally oxidized surface. Hence, we conclude that bioactive titanium substrate showing osteoconduction can be produced by designed machining followed by thermal oxidation at an appropriate temperature.

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Cell proliferation and tissue compatibility of organic-inorganic hybrid materials

Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka

Key Engineering Materials 377 167 - 180 2008年

記述言語：英語

Sol-gel preparation of few organic-inorganic hybrids have been reviewed briefly as well as their behaviors under contact with blood plasma using a simulated body fluid (SBF) of the Kokubo recipe mimicking plasma. The starting resources of the hybrids included not only such silanes as poly(dimethylsiloxane) (PDMS), 3-glycidoxypropyltrimethoxysilane (GPTMS), tetraethoxysilane (TEOS), and titanium tetra-isopropoxide, but gelatin and chitosan. Apatite deposition in SBF was examined for the solid hybrids or membranes, and cell compatibility was assessed on proliferating osteoblastic cells (MC3T3E1, MG63). In addition, 3-dimensional interconnected pore structure was established for those hybrids, for which the possibility for scaffold and bioreactor applications was examined in terms of cell proliferation of human hepatocytes or keratinocytes. Gelatin-GPTMS and PDMS-TEOS scaffolds were implanted in brain defects to see no inflammation. Nerve cell tissue regeneration was observed, which was enhanced by the impregnation of growth factors, like bFGF and VEGF. With observing those empirical data, the silane based organic-inorganic hybrids have been considered very promising for tissue regeneration scaffolds. © 2008 Trans Tech Publications.

DOI： 10.4028/0-87849-395-6.167

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The microstructure of bioceramics and its analysis

Satoshi Hayakawa, Kanji Tsuru, Akiyoshi Osaka

Bioceramics and their Clinical Applications 53 - 77 2008年

Hybrid chitosan membranes tested in sheep for guided tissue regeneration

P. P. Cortez, Y. Shirosaki, C. M. Botelho, M. J. Simoes, F. Gartner, R. M. Gil da Costa, K. Tsuru, S. Hayakawa, A. Osaka, M. A. Lopes, J. D. Santos, A. C. Mauricio

BIOCERAMICS, VOL 20, PTS 1 AND 2 361-363 1265 - + 2008年

記述言語：英語出版者・発行元：TRANS TECH PUBLICATIONS LTD

Previous in vitro studies confirmed an improved cytocompatibility of chitosan-silicate hybrid membranes over chitosan membranes. The main goal of this study was to assess the in vivo histocompatibility of both membranes through subcutaneous implantations at different time periods.. I week, 1, 2 and 3 months, using a sheep model. Chitosan membranes elicited an exuberant inflammatory response and were consequently rejected. The hybrid chitosan membranes were not rejected and the degree of inflammatory response decreased gradually until the third month of implantation. Histological evaluation also showed that these membranes can be resorbed in vivo. This study demonstrates that the incorporation of silicate into the chitosan solution improves its histocompatibility, indicating that the hybrid chitosan-silicate membranes are suitable candidates to be used in clinical applications.

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Biodegradable chitosan-silicate porous hybrids for drug delivery

Y. Shirosaki, K. Tsuru, S. Hayakawa, A. Osaka

BIOCERAMICS, VOL 20, PTS 1 AND 2 361-363 1219 - + 2008年

記述言語：英語出版者・発行元：TRANS TECH PUBLICATIONS LTD

Porous chitosan-silicate hybrids were prepared by freeze-drying the precursor sol solutions synthesized from chitosan and 3-glycidoxypropyltrimethoxysilane (GPTMS). Degradability of and the release of cytochrome C in to phosphate buffer saline solution (PBS) were examined as a function of the GPTMS content. The hybrids were less degradable with larger GPTMS contents, and the cytochrome C release profile was so controllable as to give either burst release or slow one due to the GPTMS content. Thus, the present porous chitosan-silicate hybrids were considered applicable to drug delivery systems.

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Sol-gel synthesis and in vitro cell compatibility analysis of silicate-containing biodegradable hybrid gels

K. Tsuru, Z. Robertson, B. Annaz, I. R. Gibson, S. M. Best, Y. Shirosaki, S. Hayakawa, A. Osaka

BIOCERAMICS, VOL 20, PTS 1 AND 2 361-363 447 - + 2008年

記述言語：英語出版者・発行元：TRANS TECH PUBLICATIONS LTD

Novel hybrid gels in the system gelatin-GPTMS-TEOS were prepared via a sol-gel route, and their ability to release Si(IV) was examined using MG63 osteoblast-like cell culture. The amount of Si released and the release rate were controllable by changing the mixing ratio of GPTMS and TEOS. In addition, the hybrids had biocompatible surfaces. It is expected that the hybrids will be utilized for the investigation of the effect of Si on cell differentiation and tissue regeneration.

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Preparation and characterization of boron-containing hydroxyapatite

Satoshi Hayakawa, Akihito Sakai, Kanji Tsuru, Akiyoshi Osaka, Eiji Fujii, Koji Kawabata, Christian Jaeger

BIOCERAMICS, VOL 20, PTS 1 AND 2 361-363 191 - + 2008年

記述言語：英語出版者・発行元：TRANS TECH PUBLICATIONS LTD

Boron-containing hydroxyapatite (BHAp) particles were synthesized by the wet chemical processing method and subsequent thermal treatment at the temperature ranging from 700-1200 degrees C, and examined the effect of boron introduction on the microstructure of BHAp. The local structure around boron and phosphorus in the BHAp was analyzed by solid-state magic-angle spinning (MAS) nuclear magnetic resonance (NMR) spectroscopy. The heat-treatment above 700 degrees C induced the thermal decomposition of HAp to beta-TCP and then the chemical reaction between HAp and B(OH)3 was induced above 900 degrees C, resulting in the formation of boron-substituted HAp particles accompanied by the formation of beta-TCP and its transformation to alpha-TCP above 1200 degrees C.

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生体用結晶化ガラス

尾坂明義, 早川聡, 都留, 寛治, 城﨑由紀

セラミックス 43 ( 12 ) 1055 - 1061 2008年

Structure and in vitro solubility of silicon-substituted hydroxyapatite

Tomoko Kanaya, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka, Eiji Fujii, Koji Kawabata, Georgiana Gasqueresc, Christian Bonhornme, Florence Babonneau

BIOCERAMICS, VOL 20, PTS 1 AND 2 361-363 63 - + 2008年

記述言語：英語出版者・発行元：TRANS TECH PUBLICATIONS LTD

Hydroxyapatite (HAp) and Si-containing hydroxyapatite (SiHAp) particles were of synthesized by a wet chemical method. Local structures around Si, P and H in the hydroxyapatites were analyzed by solid-state magic-angle spinning nuclear magnetic resonance spectroscopy. In vitro solubility of those SiHAp particles was evaluated by soaking them in acetic acid/acetate buffer IF solution (pH=4.0) at 36.5 degrees C. As the Si content increased, the in vitro solubility of the SiHAp particles increased, while their crystallite size changed little.

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Synthesis and characterization of Mg-containing nano-apatite

Satoshi Hayakawa, Akiyoshi Osaka, Kanji Tsuru, Eiji Fujiid, Kouji Kawabata, Kanae Ando, Christian Bonhomme, Florence Babonneau

BIOCERAMICS, VOL 20, PTS 1 AND 2 361-363 47 - + 2008年

記述言語：英語出版者・発行元：TRANS TECH PUBLICATIONS LTD

Nano-crystalline Mg-containing hydroxyapatite (Mg.HAp) were prepared by a wet chemical method, for which selective adsorption of proteins was examined, taking bovine serum albumin (BSA) and a pathogenic protein beta(2)-microglobulin (beta(2)-MG) as the model proteins. Increase in the Mg content led to smaller crystallites and larger specific surface area (SA) of Mg.HAps as well as zeta potential, while the amount both of BSA and beta(2)-MG adsorption on Mg.HAp particles. It is thus concluded that the adsorption of BSA and beta(2)-MG on Mg.HAp was associated with surface charges.

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Enhanced in vitro apatite-forming ability of sol-gel derived titania films by ultraviolet irradiation

T. Shozui, K. Tsuru, S. Hayakawa, A. Osaka

BIOCERAMICS, VOL 20, PTS 1 AND 2 361-363 601 - 604 2008年

記述言語：英語出版者・発行元：TRANS TECH PUBLICATIONS LTD

Ultraviolet (UV) light was irradiated in air for 1 h on titania (anatase) films sol-gel derived on Ti, stainless steel, alumina, and glass slide substrates, coded as C5Ti, C5SUS, C5Al(2)O(3) and C5GS, respectively. They were then soaked in a simulated body fluid (SBF, Kokubo solution) and their apatite-forming ability (bioactivity) was evaluated. UV light irradiated C5SUS deposited bone-like apatite within 7 days whereas C5SUS did not within 7 days. Moreover, the apatite was deposited faster on UV light irradiated C5Ti than on C5Ti without UV light irradiation, whereas UV light irradiated C5GS, C5Al(2)O(3) and C5GS did not apatite within 7 days. Therefore, the ultraviolet light irradiation was confirmed to enhance in vitro apatite-forming ability of the sol-gel derived titania films on various substrates, but the effect depended on substrates.

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UV irradiation enhanced in vitro apatite-forming ability of the sol-gel derived titania on Ti, SUS, alumina, and Na-Ca glass substrates

Tetsuya Shozui, Kanji Tsuru, Satoshi Hayakawa, Yuki Shirosaki, Akiyoshi Osaka

Archieves of Bio Ceramics Research 8 85 - 88 2008年

Solid state NMR characterization of nano-crystalline hydroxy-carbonate apatite using 1H-31P-13C triple resonance experiments

Florence Babonneau, Christian Bonhomme, Satoshi Hayakawa, Akiyoshi Osaka

Materials Research Society Symposium Proceedings 984 39 - 44 2007年12月

The local structure around hydrogen atoms, phosphate ions and carbonate ions in nano-crystalline nonstoichiometric hydroxy-carbonate apatite was investigated in this study. The use of C enriched precursors allowed to perform 1D and 2D CP MAS HETCOR (HETeronuclear CORrelation) experiments with 13C as a target spin. 2D triple resonance experiments involving the 1H/13C/31P spins were also performed. All these experiments led to the partial editing of the corresponding projection spectra and revealed fine structural details for the corresponding material. At least four 13C peaks, corresponding to carbonate ions in A-sites (OH) and B-sites (PO43-) were evidenced. © 2007 Materials Research Society.

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硫酸チタンの加水分解により合成されたルチル及びアナターゼ型酸化チタンの擬似体液中におけるアパタイト析出

尾坂明義, 早川聡, 都留寛治

硫酸と工業 60 ( 3 ) 44 - 50 2007年3月

Medical Applications of Hybrid Materials

Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka

Hybrid Materials: Synthesis, Characterization, and Applications 301 - 335 2007年2月

より豊かな生活に貢献する医療技術に関する研究歯周炎と人工歯根周囲炎に罹患した歯周組織再生のための局所的遺伝子・細胞治療用人工素材の開発

高柴正悟, 鈴木一臣, 尾坂明義, 早川聡, 明貝文夫

医科学応用研究財団研究報告 24 74 - 79 2007年2月

記述言語：日本語出版者・発行元：(公財)鈴木謙三記念医科学応用研究財団

臨床応用可能な歯周組織再生のための人工素材を開発するため、新規の歯周組織再生素材を開発し、その組織再生誘導能をin vitroおよびin vivoの実験系で検証し、抗菌物質の適応によって口腔内の細菌感染のコントロールを評価した。MC3T3-E1細胞の増殖能は、CAの濃度依存的に有意に抑制された。低濃度のヒドロキシアパタイト(HA)および歯科用骨補填材ボーンジェクト(BJ)は細胞を刺激しない場合と比較して、有意に細胞増殖活性を亢進し、高濃度のHAおよびBJの添加によって細胞増殖活性の程度に有意な変化はなかった。SDラットの口蓋骨欠損部にCAを填人した後、2週間経過したラット口蓋骨欠損部の新生骨形成量は、BJを填入した群と比較して明らかに増加傾向を示した。hb42を唾液腺に遺伝子導入したラットの口腔内細菌量は、対照ラットと比較して有意に減少した。

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