研究者詳細 - 早川　聡

MISC - 早川　聡

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チタン系インプラントの表面改質—酸化チタン層への紫外線照射による生体親和性の向上

早川聡, 尾坂明義, 城﨑由紀

チタン 58 ( 2 ) 54 - 56 2010年

105 GRAPE^<[○!R]> Technology : チタンに骨組織親和性を与える空間デザインと熱処理(生体・医療材料I,生体・医療材料,オーガナイスドセッション10)

杉野篤史, 土居憲司, 藏本孝一, 都留寛治, 大槻主税, 早川聡, 城崎由紀, 尾坂明義

学術講演会講演論文集 59 9 - 10 2010年

In vitro cytocompatibility of injectable chitosan-silicate hydrogel

Yuki Shirosaki, Masashi Hirai, Satoshi Hayakawa, Maria A. Lopes, José D. Santos, Akiyoshi Osaka

Archives of Bio Ceramics Research 10 14 - 17 2010年

Effect of UV-irradiation environment on induction time for apatite nucleation on TiO2 layer

Keita Uetsuki, Shinsuke Nakai, Yuki Shirosaki, Satoshi Hayakawa, Akiyoshi Osaka

Archives of Bio Ceramics Research 10 50 - 53 2010年

リン酸エステル系機能性モノマーによる歯質接着界面の形成メカニズムの解明

吉原久美子, 早川聡, 長岡紀幸, 吉田靖弘, 鈴木一臣, 皆木省吾

歯科材料・器械 28 ( 2 ) 51 - 51 2009年3月

医用金属チタンの生体親和性の制御

早川聡, 城﨑由紀, 尾坂明義

未来材料（株）エヌ・ティー・エス 9 ( 5 ) 38 - 44 2009年

Viscoelastic Property of collagen gels with aligned fibril structure

Y. LiN, Hirota, M.Okuda, S.Chen, M.Tagaya, Y.Shirosaki, S.Hayakawa, A.Osaka, N.Hanagata, T. Ikoma

Bioceramics 22 661 - 664 2009年

A NMR Investigation of Borate Incorporation in Apatitic Biomaterials

S. Barheine, S. Hayakawa, A. Osaka, C. Jaeger

BIOCERAMICS 21 396-398 205 - 208 2009年

記述言語：英語出版者・発行元：TRANS TECH PUBLICATIONS LTD

The incorporation of ions in the lattice of hydroxyapatite alters significantly its structure. Particularly, if anions such as trigonal borate units are accommodated in the lattice severe distortions must occur around the substitution site because of different geometric shape, electric charge and anion size. Solid-state NMR has been used to investigate this problem in detail for a hydroxyapatite sample synthesized by high temperature solid state reaction. The results clearly verify the existence of network distortions. Indeed, only about 1/3 of the total phosphate content forms crystalline hydroxyapatite (also found in XRD) whereas the residual amount is contained in two different phosphate sites with 31 p chemical shifts of 5.5 ppm and 2.3 ppm, but broad resonances lines suggesting disorder. Furthermore, a novel proton signal at -0.6 ppm was found which is directly associated with the borate incorporation. No specific correlation of the two structurally different berate units with the two phosphate groups is found.

DOI： 10.4028/0-87849-353-0.205

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Effect of Si(IV) released from chitosan-silicate hybrids on proliferation and differentiation of MG63 osteoblastic cells

Y. Shirosaki, K. Tsuru, S. Hayakawa, Y. NakamuraI, R. Gibson, A. Osaka

Bioceramics 22 217 - 220 2009年

A Novel Method of Preparing a Nano-meter Rod Array of Hydroxyapatite Crystals

S. HayakawaY. LiY, ShirosakiA, OsakaE, FujiiK. Kawabata

Bioceramics 22 89 - 92 2009年

Apatite-forming ability on spatial design enhanced by autoclaving

Yoko Nakao, Atsushi Sugino, Kanji Tsuru, Keita Uetsuki, Yuki Shirosaki, Satoshi Hayakawa, Akiyoshi Osaka

Archives of Bio Ceramics Research 9 387 - 390 2009年

ULTRAVIOLET IRRADIATION HAD LIMITED EFFECTS ON ENHANCING IN VITRO APATITE FORMATION ON SOL-GEL DERIVED TITANIA FILMS 査読

Akiyoshi Osaka, Tetsuya Shozui, Kanji Tsuru, Satoshi Hayakawa

ADVANCES IN BIOCERAMICS AND POROUS CERAMICS 29 ( 7 ) 199 - 210 2009年

記述言語：英語出版者・発行元：AMER CERAMIC SOC

As UV irradiation on titania causes several effects, such as decomposing organic substances and attaining super-hydrophilic surfaces. the present study explored the UV irradiation effects on apatite deposition on titania gel films (anatase) that were developed on a few substrates: pure titanium (Ti), stainless-steel (SUS316L), alumina (Al(2)O(3)) and glass slide (GS). Those substrates were dip-coated with a precursor sot (Ti(OC(2)H(5))(4) : C(2)H(5)OH : H(2)O : HNO(3) = 1 : 50 : 2 : 0.2) and heated at 500 degrees C for 10 min before irradiated with UV light (365 nm, 170 mW/cm(2)) in air for 1 h. They were subsequently soaked in simulated body fluid (SBF. Kokubo solution) and their in vitro apatite formation was evaluated by X-ray diffractometry and scanning electron micrograph. It was found that the UV irradiation enhanced apatite formation on the titania gel film on Ti and SUS by shortening the induction time. However, least effects were found for the titania gel films on Al(2)O(3) and GS as they did not deposit apatite within 7 days, even with the UV irradiation. These results indicated that UV irradiation had limited effects to enhance in vitro apatite formation on the titania films, i.e., it depended on the substrates.

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PREPARATION AND BIOMINERALIZATION OF SILICA-BASED ORGANIC-INORGANIC HYBRID HOLLOW NANOPARTICLES FOR BONE TISSUE GENERATION 査読

Song Chen, Akiyoshi Osaka, Kanji Tsuru, Satoshi Hayakawa

ADVANCES IN BIOCERAMICS AND POROUS CERAMICS 29 ( 7 ) 19 - 26 2009年

記述言語：英語出版者・発行元：AMER CERAMIC SOC

Novel bioactive silica-based organic-inorganic hollow hybrid particles involving Ca(2+) ions for stimulating and inducing bone generation were prepared via a templating synthesis route. The solid hybrid nanoparticles were first derived from the core-silica particles and natural polymer shell layers that were composed of chitosan and calcium alginate. They were then soaked in a concentrated NaOH solution and subjected to controlled dissolution of the core-silica, which led to yielding the hollow hybrid particles. The resultant particles were spherical in shape, with the porous surface. The polymer shells suppressed the dissolution behavior of the core-silica, and thus a partially void structure was formed inside the hybrid particles. An Energy Dispersion Spectroscopic analysis indicated that the polymer shells retained much silica and offered a matrix to maintain the spherical shape of the partially hollow particles. When soaked in the Kokubo's simulated body fluid (SBF), the hollow particles deposited apatite crystals within one week, that is, they exhibited strong bioactivity. In contrast, it took one month or longer for the apatite to be deposited on the naked silica particles without the polymer shell coatings layers. Thus, Ca in the hollow particles significantly accelerated apatite formation. Therefore, the present organic-inorganic hollow particles could be a promising candidate for bone regeneration drug or factor carriers.

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Nerve regeneration guided by chitosan hybrid membranes

Yuki Shirosaki, Maria A. Lopes, José D. Santos, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka, Ana C. Maurício, Stefano Geuna

Archives of Bio Ceramics Research 9 147 - 150 2009年

GRAPE® technology improves apatite-formation on thermally derived titania layer

Atsushi Sugino, Keita Uetsuki, Yuki Shirosaki, Satoshi Hayakawa, Kanji Tsuru, Chikara Ohtsuki, Akiyoshi Osaka

Archives of Bio Ceramics Research 9 175 - 178 2009年

骨分化を促進するキトサンハイブリッド膜の創製

城崎由紀, 盛林洋史, 中村有里, 都留寛治, 早川聡, 尾坂明義

キチン・キトサン研究 15 ( 2 ) 2009年

Study of biomaterials by solid-state NMR: HAp layer on active bioglass

F. Pourpoint, C. Bonhomme, C. Gervais, G. Gasqueres, A. J. Salinas, S. Hayakawa, A. Osaka

8th World Biomaterials Congress 2008 2 865 2008年12月

Preparation, characterization and biological assessment of bioactive and mesoporous silica nanoparticle coatings for bone regeneration

Song Chen, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka

A Global Road Map for Ceramic Materials and Technologies: Forecasting the Future of Ceramics, International Ceramic Federation - 2nd International Congress on Ceramics, ICC 2008, Final Programme 2008年12月

Bioactive porous silica particle coatings were fabricated on the stainless steel substrates as bone repairing implants to enhance the apatite deposition. The particles were prepared from tetraethoxysilane (TEOS) and cetyltrimethylammonium bromide (CTAB) via the sol-gel method and then calcined at 600°C for 2 h to produce the porous structure. Subsequently, the clean substrates were sequentially soaked in the chitosan, silica and calcium alginate solutions to obtain the chitosan/silica/calcium alginate coatings via the charged layer-by-layer deposition technique. The treated substrates deposited bioactive apatite when soaked in the Kokubo's simulated body fluid (SBF) and exhibited bioactivity. Thus, such bioactive porous silica coatings are applicable to the reservoirs for storing and releasing the bone factors.

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Preparation of silica-natural polymer hybrid nanoparticles for clinical applications

Song Chen, Kanji Tsuru, Satoshi Hayakawa, Lei Ren, Qiqing Zhang, Akiyoshi Osaka

8th World Biomaterials Congress 2008 1 338 2008年12月

Structure of substituted hydroxyapatite: The solid state nmr (nuclear magnetic resonance) point of view.

C. Bonhomme, F. Babonneau, C. Gervais, F. Pourpoint, G. Gasqueres, S. Hayakawa, A. Osaka

8th World Biomaterials Congress 2008 2 920 2008年12月

We have shown that the combination of advanced solid state NMR experiments [7] and ab initio calculations of NMR parameters can lead to a novel description of substituted HAp structures. In the case of silicate substitution, the anions located within the structure are unambiguously characterized by selective 1H → 29Si CP transfer and 31P → 29Si experiments can edit the 29Si MAS spectra in terms of 31P/29Si dipolar interaction. 2D heteronuclear interactions will be performed in a near future. In the case of carbonate substituted HAp, the study of the 1H → 13C dynamics allowed to fully characterize the various 13C sites. By combining NMR calculations starting from DFT models and experiments, distributions of A-, B- and A/B sites were clearly characterized.

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