Updated on 2025/02/12

写真a

 
HAYAKAWA Satoshi
 
Organization
Faculty of Interdisciplinary Science and Engineering in Health Systems Professor
Position
Professor
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Degree

  • Master of Science ( Kobe University )

  • Doctor of Engineering ( Kyoto University )

Research Interests

  • 無機素材化学

  • Biomaterials

  • 無機生体材料学

  • 生体素材工学

  • Solid State Chemistry

Research Areas

  • Nanotechnology/Materials / Nanobioscience

  • Nanotechnology/Materials / Nanomaterials

  • Nanotechnology/Materials / Inorganic materials and properties

  • Life Science / Biomaterials

  • Life Science / Biomedical engineering

Education

  • Kyoto University   工学研究科   分子工学専攻

    - 1994

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    Country: Japan

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  • Kyoto University    

    - 1994

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Research History

  • Okayama University   Academic Field of Interdisciplinary Science and Engineering in Health Systems, Academic Research Assembly   Professor

    2021.4

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    Country:Japan

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  • Okayama University   大学院ヘルスシステム統合科学研究科

    2020.4 - 2022.3

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    Country:Japan

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  • Okayama University   Graduate School of Interdisciplinary Science and Engineering in Health Systems   Professor   Professor

    2018.4 - 2021.3

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  • Okayama University   大学院ヘルスシステム統合科学研究科

    2018.4 - 2020.3

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  • Okayama University   The Graduate School of Natural Science and Technology   Professor   Professor

    2013.4 - 2018.3

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Professional Memberships

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Committee Memberships

  • 日本バイオマテリアル学会   評議員  

    2021.4   

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    Committee type:Academic society

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  • 日本セラミックス協会中国四国支部   理事  

    2013.4   

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    Committee type:Academic society

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  • 日本セラミックス協会生体関連材料部会   幹事  

    1997.4   

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    Committee type:Academic society

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Papers

  • Improvement of caffeine adsorption on octacalcium phosphate through suberate ion incorporation

    Takuya Kataoka, Ayumi Koga, Seita Nishiyama, Tomohiko Yoshioka, Satoshi Hayakawa

    Materials Letters   385   138188 - 138188   2025.4

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    Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.matlet.2025.138188

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  • Comparative study of the effects of fluoride treatment with cyclic variations in pH on the structures of stoichiometric, calcium-deficient, and carbonated hydroxyapatites

    Satoshi Hayakawa, Yu Okada, Tomohiko Yoshioka

    Journal of the Ceramic Society of Japan   133 ( 1 )   15 - 24   2025.1

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    Publishing type:Research paper (scientific journal)   Publisher:Ceramic Society of Japan  

    DOI: 10.2109/jcersj2.24094

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  • Electrochemically assisted sol-gel deposition of bioactive gels for biomedical applications Reviewed

    Tomohiko Yoshioka, Naoki Miyamoto, Satoshi Hayakawa

    Journal of Sol-Gel Science and Technology   112 ( 2 )   419 - 424   2024.9

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    Authorship:Last author   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    Abstract

    So far, the sol-gel process has been available to prepare precursor gels of bioactive glasses with various compositions. In this report, we described a novel coating method of bioactive gels on a titanium substrate where the sol-gel transition is controlled by applying external electric fields. The application of a constant current of 10 mA/cm2 in an acidic sol containing pre-hydrolyzed tetraethoxysilane, calcium nitrate, and ammonium dihydrogen phosphate led to the deposition of gels on the titanium cathodes due to the generation of OH by water electrolysis as a catalyst of the sol-gel transition. The obtained gels, which were characterized to be amorphous and consisted of Si, Ca, and P, covered the titanium substrates as a coating. The bioactivity of the gels deposited was confirmed by soaking in a simulated body fluid (SBF) up to 7 days, suggesting that the electrochemically assisted sol-gel process is promising for providing bioactive coatings on metallic implants.

    Graphical Abstract

    DOI: 10.1007/s10971-024-06530-6

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    Other Link: https://link.springer.com/article/10.1007/s10971-024-06530-6/fulltext.html

  • Synthesis and structural characterization of Sr(II) ion-containing octacalcium phosphate incorporated with both 2,6-pyridinedicarboxylate and succinate ions as a bone defect filler with multiple drug loading capability Reviewed

    Takuya Kataoka, Seita Nishiyama, Eiji Fujii, Tomohiko Yoshioka, Satoshi Hayakawa

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   134001 - 134001   2024.4

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    Authorship:Last author   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.colsurfa.2024.134001

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  • Effect of chitosan content on protein adsorption capacity of Mg(II) ion-containing apatite/chitosan composite particles Reviewed

    Takuya Kataoka, Wataru Nishizaki, Yuhi Yasuhira, Eiji Fujii, Tomohiko Yoshioka, Satoshi Hayakawa

    Journal of the Ceramic Society of Japan   2024

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    Authorship:Last author   Publishing type:Research paper (scientific journal)   Publisher:Ceramic Society of Japan  

    DOI: 10.2109/jcersj2.24085

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Books

  • Hydroxyapatite (HAp) for Biomedical Applications

    Woodhead Publishing  2015  ( ISBN:9781782420

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  • Bioceramcs and their clinical applications

    Woodhead publishing limited, Cambridge, England  2008 

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  • Advances in Bioceramics and Biocomposites II, Ceramic Engineering and Science Proceedings , Volume 27, Issue 6,

    A JOHN WILEY & SONS, INC., PUBLICATION, New Jersey  2007 

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  • HYBRID MATERIALS- Synthesis, Characterization, and Applications

    Wiley-VCH, Verlag GmbH & Co. KGaA, Weinheim  2007 

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  • HANDBOOK OF SOL-GEL SCIENCE AND TECHNOLOGY Processing Characterization and Applications, APPLICATIONS of SOL-GEL TECHNOLOGY

    Kluwer Academic Publishers  2005 

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MISC

  • Molecular Structure Analysis (2) (NMR) -Structural Nalaysis of Inorganic Materials by Solid-state NMR Invited

    Satoshi Hayakawa

    Ceramics Japan (Bulletin of the Ceramics Society of Japan)   59 ( 1 )   36 - 41   2024.1

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

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  • Incorporation of enzyme into silica gels by the sol-gel reaction using AC electrolysis and evaluation of the enzyme activity

    吉岡朋彦, 谷口功治, 片岡卓也, 早川聡

    日本セラミックス協会年会講演予稿集(Web)   2024   2024

  • バイオセラミックスの最新の研究動向と将来展望

    橋本雅美, 澤村武憲, 早川 聡

    セラミックス   51 ( 12 )   836 - 840   2016

  • The State of Art of Research and Development in Bioceramics

    Masami Hashimoto, Takenori Sawamura, Satoshi Hayakawa

    CERAMICS JAPAN BULLETIN OF THE CERAMICS SOCIETY OF JAPAN   51 ( 12 )   836 - 840   2016

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  • In vitro degradation behavior of hydroxyapatite

    S. Hayakawa

    Hydroxyapatite (HAp) for Biomedical Applications   85 - 105   2015.2

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    Language:English   Publisher:Elsevier Ltd  

    This chapter discusses in vitro degradation behaviors of calcium phosphate particles, such as nano-crystalline hydroxyapatite (HAp) and ion-substituted HAp synthesized by the wet-chemical processing method, and how their microstructure affects their initial dissolution profiles and kinetics. The chapter reviews several in vitro evaluation techniques for biodegradability of calcium phosphate ceramics and several models representing dissolution profiles and kinetics. The chapter then discusses the relationship between the heterogeneous structure of nano-crystalline HAp and the initial dissolution behaviors in acidic buffer solution.

    DOI: 10.1016/B978178242033000004-3

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Presentations

  • Chemical structure and biological properties of organic-inorganic composite thin films

    Kazutaka Kumamoto, Toshinari Maeda, Nurul Asyfah Binti Mustapha, Satoshi Hayakawa, Yuki Shirosaki

    2021.1.7 

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    Event date: 2021.1.7 - 2021.1.8

    Language:English   Presentation type:Oral presentation (general)  

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  • キトサン-シロキサン複合体から溶出したケイ素化合物の構造と神経細胞に対する 影響

    服部晃世, 城﨑由紀, 早川聡

    日本セラミックス協会第33 回秋季シンポジウム  2020.9.2 

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    Event date: 2020.9.2 - 2020.9.4

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • バシトラシン亜鉛を担持した有機-無機複合体薄膜の創製

    隈元和貴, 前田憲成, Nurul Asyfah Binti Mustapha, 城﨑由紀, 早川聡

    日本セラミックス協会第33 回秋季シンポジウム  2020.9.2 

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    Event date: 2020.9.2 - 2020.9.4

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 様々なアパタイトの析出機序と微細構造に関する考察

    早川 聡

    第8 回 日本バイオマテリアル学会 中四国ブロック シンポジウム  2020.2.6 

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    Event date: 2020.2.6

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 抗菌薬担持有機-無機複合体薄膜の創製

    隈元和貴, 前田憲成, Nurul Asyifah Binti Mustapha, 城﨑由紀, 早川聡

    日本女性科学者の会2019 年度例会新春シンポジウム  2020.1.12 

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    Event date: 2020.1.12

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Works

  • マイクロ空間デザインによるチタン系医用金属への骨伝導性付与

    2008

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    Work type:Artistic work  

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Awards

  • ACTA BIOMATERIALIA 2016 Reviewer Award

    2017  

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  • アメリカ材料学会Ribbon award

    2005  

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    Country:Japan

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  • 日本セラミックス協会2004 JCerSJ優秀論文賞

    2005  

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    Country:Japan

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  • 岡山工学振興会 科学技術賞

    2003  

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    Country:Japan

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  • 第52回日本セラミックス協会賞進歩賞(第652号)

    1998  

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    Country:Japan

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Research Projects

  • 酸化ジルコニウムナノ粒子層によるジルコニウム系インプラント材料の高生体機能化

    Grant number:24K08202  2024.04 - 2027.03

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    早川 聡

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    Grant amount:\4680000 ( Direct expense: \3600000 、 Indirect expense:\1080000 )

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  • Specification of Si(IV) species structure to cellular response for new tissue engineering scaffolds

    Grant number:19H04471  2019.04 - 2022.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    SHIROSAKI YUKI

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    Grant amount:\16380000 ( Direct expense: \12600000 、 Indirect expense:\3780000 )

    Many studies have been reported on osteoblast compatibility and bone regeneration using composites and hybrids, including silica or siloxane units. However, it is not clear the structure of molecules involving silicon atoms that has a more effective role in the cell activity and their mechanisms of cell activation. In this study, we prepared hybrid materials from chitosan and different types of alkoxysilane and investigated the structures of the silicon-containing species dissolved from each hybrid and their effect on the proliferation of nerve cells.

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  • 階層構造制御型セラミック基生医材料の創製と生医機能の複合的発現

    2012.04 - 2016.03

    日本学術振興会  科学研究費補助金 基盤研究B 

    早川 聡

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    Authorship:Principal investigator  Grant type:Competitive

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  • 隙間空間を利用したチタン系医用インプラント材料の設計と評価方法の開発

    2012.04 - 2014.03

    日本学術振興会  科学研究費補助金 挑戦的萌芽研究 

    早川 聡

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    Authorship:Principal investigator  Grant type:Competitive

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  • A multifunctional implant which can achieve the site-specific tissue regeneration

    Grant number:22390366  2010.04 - 2014.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    MAEKAWA Kenji, HAYAKAWA Satoshi, SONOYAMA Wataru, KUBOKI Takuo, ITOH Yoshihiro

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    Grant amount:\19240000 ( Direct expense: \14800000 、 Indirect expense:\4440000 )

    Our previous technique for apatite deposition onto the titanium surface after insertion in human body, can be only applied to the pure titanium surface. However, in order to apply this surface modification technique to clinically used implants, improvement of the technique is necessary, because all the commercially available titanium implants are made from titanium alloy. For this purpose, we developed liquid phase deposition (LPD) technique, which can induce the apatite formation onto the titanium alloy surface after insertion in human body. We found that rat bone marrow stromal cells (rBMSC) can be attached to this modified titanium alloy surface (treated by LPD technique) and the osseogenesis of rBMSC tended to be accelerated. Recently, the investigation of the bioactivity of this surface modification technique using rat model is still ongoing.

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Class subject in charge

  • General Biotechnology and Drug Discovery Technology (2024academic year) Prophase  - 木1~2

  • Advanced Internship for Interdisciplinary Medical Sciences and Engineering (2024academic year) Year-round  - その他

  • Internship for Interdisciplinary Medical Sciences and Engineering (2024academic year) Year-round  - その他

  • Technical English for Interdisciplinary Medical Sciences and Engineering (2024academic year) Late  - その他

  • Introduction to Interdisciplinary Science and Engineering in Health Systems (2024academic year) Prophase  - 火1~2

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