研究者詳細 - 森實　祐基

論文 - 森實　祐基

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網膜細動脈瘤破裂による黄斑下血腫において網膜内出血の有無が視力予後に及ぼす影響

土居真一郎, 木村修平, 森實祐基, 細川海音, 塩出雄亮, 平野雅幸, 戸島慎二, 高橋耕介, 松前洋, 神崎勇希, 藤原篤之, 岡野内俊雄, 白神史雄

日本眼科学会雑誌 122 ( 臨増 ) 217 - 217 2018年3月

内境界膜剥離を併用した網膜下注入の安全性の検討注入圧の違いが網膜へ及ぼす影響

高橋耕介, 森實祐基, 立花崇, 久冨智朗, 木村修平, 細川海音, 塩出雄亮, 平野雅幸, 土居真一郎, 戸島慎二, 荒木亮一, 園田康平, 白神史雄

日本眼科学会雑誌 122 ( 臨増 ) 219 - 219 2018年3月

健常眼の中心窩無血管領域面積の左右差の検討

藤原篤之, Liu Mengxuan, 森實祐基, 細木三佳, 木村修平, 細川海音, 塩出雄亮, 平野雅幸, 土居真一郎, 戸島慎二, 高橋耕介, 松前洋, 神崎勇希, 白神史雄

日本眼科学会雑誌 122 ( 臨増 ) 298 - 298 2018年3月

実臨床における糖尿病黄斑浮腫治療の実態 VEGF阻害薬治療

村松大弐, 志村雅彦, 内海卓也, 北野滋彦, 福嶋はるみ, 高村佳弘, 松本牧子, 築城英子, 森實祐基, 厚東隆志, 園田祥三, 石川裕人, 五味文, 香留崇, 三田村佳典, 木村和博, 木下貴正, 杉本昌彦, 近藤峰生, 引地泰一, 鷲尾紀章, 佐藤智人, 竹内大, 辻中大生, 緒方奈保子, 楠原仙太郎, 坂本泰二, J-CREST Study Group

日本眼科学会雑誌 122 ( 臨増 ) 240 - 240 2018年3月

実臨床における糖尿病黄斑浮腫治療の実態介入治療開始年度比較

志村雅彦, 内海卓也, 北野滋彦, 福嶋はるみ, 村松大弐, 高村佳宏, 松本牧子, 築城英子, 森實祐基, 厚東隆志, 園田祥三, 石川裕人, 五味文, 香留崇, 三田村佳典, 木村和博, 木下貴正, 杉本昌彦, 近藤峰生, 引地泰一, 鷲尾紀章, 佐藤智人, 竹内大, 辻中大生, 緒方奈保子, 楠原仙太郎, 坂本泰二, J-CREST Group

日本眼科学会雑誌 122 ( 臨増 ) 240 - 240 2018年3月

紫外線受容視物質オプシン5のニワトリ胚線維芽細胞における作用

加藤睦子, 佐藤恵太, 藤田洋史, 板東哲哉, 森實祐基, 中山正, 白神史雄, 大内淑代

日本眼科学会雑誌 122 ( 臨増 ) 185 - 185 2018年3月

黄斑上膜による網膜牽引が視機能に及ぼす影響

平野雅幸, 神崎勇希, 森實祐基, 木村修平, 細川海音, 塩出雄亮, 土居真一郎, 戸島慎二, 高橋耕介, 松前洋, 藤原篤之, 細木三佳, 高須逸平, 白神史雄

日本眼科学会雑誌 122 ( 臨増 ) 220 - 220 2018年3月

Results of a Treat-and-Eextend Regimen of Intravitreal Ranibizumab Injection for Macular Edema due to Branch Retinal Vein Occlusion.

Mika Hosogi, Yuki Morizane, Yusuke Shiode, Shinichiro Doi, Fumiaki Kumase, Shuhei Kimura, Mio Hosokawa, Masayuki Hirano, Shinji Toshima, Kosuke Takahashi, Atsushi Fujiwara, Fumio Shiraga

Acta medica Okayama 72 ( 1 ) 39 - 45 2018年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

To investigate the effectiveness of a treat-and-extend regimen (TAE) of intravitreal ranibizumab injections (IVR) for macular edema (ME) due to branch retinal vein occlusion (BRVO). We retrospectively examined 35 eyes of 35 patients with ME due to BRVO who underwent TAE for 1 year. Patients whose treatment interval extended to 12 weeks were switched to a pro re nata regimen (PRN; TAE to PRN group), while TAE was continued for patients whose treatment interval was less than 12 weeks (continued TAE group). Changes in best-corrected visual acuity (BCVA), central retinal thickness (CRT), and predictive factors for inclusion in the TAE to PRN group were analyzed. BCVA and CRT both improved significantly at 1 year compared with baseline (p<0.001). Sixteen eyes (45.7%) were included in the TAE to PRN group, while 19 eyes (54.3%) were included in the continued TAE group. BCVA in the TAE to PRN group was significantly better than that in the continued TAE group at 1 year (p=0.047). BCVA at baseline and macular BRVO were significant predictive factors for inclusion in the TAE to PRN group. TAE was effective for improving BCVA and CRT. The TAE to PRN group showed significantly better prognosis.

DOI： 10.18926/AMO/55661

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Traumatic Globe Luxation with Complete Optic Nerve Transection Caused by Heavy Object Compression.

Yoshinori Kosaki, Tetsuya Yumoto, Hiromichi Naito, Nobushige Tsuboi, Masahiro Kameda, Masayuki Hirano, Yuki Morizane, Takaya Senoo, Eijirou Tokuyama, Atsunori Nakao

Acta medica Okayama 72 ( 1 ) 85 - 88 2018年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

Traumatic eyeball luxation is a rare clinical condition with a dramatic presentation. Here, we describe a unique case of traumatic globe luxation and complete optic nerve transection caused by heavy object compression. A 45-year-old male automobile mechanic was injured when a truck slipped from its supports, crushing his head and face. On arrival, his right eyeball was obviously displaced anteriorly and he had no light perception. Computed tomography revealed complex frontal bone and facial fractures with underlying brain contusion in addition to complete transection of the right optic nerve. The patient was successfully treated using a multidisciplinary approach.

DOI： 10.18926/AMO/55669

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Issues with the Specificity of Immunological Reagents for NLRP3: Implications for Age-related Macular Degeneration. 国際誌

Cassandra Kosmidou, Nikolaos E Efstathiou, Mien V Hoang, Shoji Notomi, Eleni K Konstantinou, Masayuki Hirano, Kosuke Takahashi, Daniel E Maidana, Pavlina Tsoka, Lucy Young, Evangelos S Gragoudas, Timothy W Olsen, Yuki Morizane, Joan W Miller, Demetrios G Vavvas

Scientific reports 8 ( 1 ) 461 - 461 2018年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

Contradictory data have been presented regarding the implication of the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome in age-related macular degeneration (AMD), the leading cause of vision loss in the Western world. Recognizing that antibody specificity may explain this discrepancy and in line with recent National Institutes of Health (NIH) guidelines requiring authentication of key biological resources, the specificity of anti-NLRP3 antibodies was assessed to elucidate whether non-immune RPE cells express NLRP3. Using validated resources, NLRP3 was not detected in human primary or human established RPE cell lines under multiple inflammasome-priming conditions, including purported NLRP3 stimuli in RPE such as DICER1 deletion and Alu RNA transfection. Furthermore, NLRP3 was below detection limits in ex vivo macular RPE from AMD patients, as well as in human induced pluripotent stem cell (hiPSC)-derived RPE from patients with overactive NLRP3 syndrome (Chronic infantile neurologic cutaneous and articulate, CINCA syndrome). Evidence presented in this study provides new data regarding the interpretation of published results reporting NLRP3 expression and upregulation in RPE and addresses the role that this inflammasome plays in AMD pathogenesis.

DOI： 10.1038/s41598-017-17634-1

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【黄斑疾患の新しい概念と治療法】黄斑疾患に対する手術手技の新展開内境界膜処理と網膜下注入

森實祐基

日本の眼科 89 ( 1 ) 39 - 44 2018年1月

記述言語：日本語出版者・発行元：(公社)日本眼科医会

近年、黄斑に対する手術手技について、新たな発想に基づいて手技のバリエーションが生まれる、これまで手技の対象ではなかった疾患が対象となる、といった展開がみられている。例えば黄斑円孔に対して、これまでは内境界膜の剥離除去が行われてきた。しかし、特殊な黄斑円孔に対しては、内境界膜を剥離除去するだけでは円孔が閉鎖しないことが明らかになり、内境界膜弁翻転法や内境界膜自家移植が考案され普及してきている。現時点では、このような新しい黄斑手技の方法や適応は厳密には定まっておらず、術者の経験や好みに基づいて施行されている。今後、手技や適応の標準化に向けた検討が必要である。(著者抄録)

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The influence of subretinal injection pressure on the microstructure of the monkey retina. 国際誌

Kosuke Takahashi, Yuki Morizane, Toshio Hisatomi, Takashi Tachibana, Shuhei Kimura, Mio Morizane Hosokawa, Yusuke Shiode, Masayuki Hirano, Shinichiro Doi, Shinji Toshima, Ryoichi Araki, Hiroshi Matsumae, Yuki Kanzaki, Mika Hosogi, Atsushi Yoshida, Koh-Hei Sonoda, Fumio Shiraga

PloS one 13 ( 12 ) e0209996 2018年

記述言語：英語掲載種別：研究論文（学術雑誌）

PURPOSE: To investigate the influence of subretinal injection pressure on the microstructure of the retina in a monkey model. METHODS: After vitrectomy, balanced salt solution was injected subretinally into one eye each of four cynomolgus monkeys while controlling the injection pressure. Initially, a pressure of 2 psi was used, and this was gradually increased to determine the minimum required pressure. Subsequent injections were performed at two pressures: minimum (n = 13) and high (n = 6). To compare the influence of these injection pressures on retinal structure, optical coherence tomography (OCT) was performed before surgery and every week afterwards. The monkeys were euthanized and their eyes were enucleated at 1 or 6 weeks after the injections. The eyes were processed for light microscopy and transmission electron microscopy (TEM) as well as for TdT-mediated dUTP nick end labeling. RESULTS: The minimum pressure required to perform subretinal injection was 6 psi. After injection at this pressure, both OCT and microscopy showed that the retinal structure was well-preserved throughout the experimental period at all injection sites. Conversely, after injection at high pressure (20 psi) OCT images at all injection sites showed disruption of the ellipsoid zone (EZ) after 1 week. Microscopy indicated damage to the photoreceptor outer segment (OS) and stratification of the retinal pigment epithelium (RPE). After 6 weeks, OCT demonstrated that the EZ had become continuous and TEM confirmed that the OS and RPE had recovered. Photoreceptor apoptosis was absent after subretinal injection at both pressures. CONCLUSIONS: The retinal damage caused by subretinal injection increases depending on pressure, indicating that clinicians should perform subretinal injection at pressures as low as possible to ensure safety.

DOI： 10.1371/journal.pone.0209996

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Comparison of success rates in eye drop instillation between sitting position and supine position. 国際誌

Tomoko Naito, Keiji Yoshikawa, Koji Namiguchi, Shiro Mizoue, Atsushi Shiraishi, Yuko Ichikawa, Miyuki Fujiwara, Takako Miki, Ryoichi Araki, Yuzo Umeda, Yuki Morizane, Fumio Shiraga

PloS one 13 ( 9 ) e0204363 2018年

記述言語：英語掲載種別：研究論文（学術雑誌）

PURPOSE: To compare the success rates of eye drop instillation in the sitting position and supine position among Japanese patients with ocular diseases (cataract, glaucoma, or retinal and vitreous diseases). METHODS: Patients who were hospitalized in Okayama University Hospital for eye surgery were studied. Instillation procedures of each patient in both the sitting and supine positions were recorded using a video camera at the time of instillation. We defined "success" when one drop fell accurately onto the ocular surface at the first attempt. Instillation of two or more drops, drops delivered to a site other than the eye surface, and touching the eyelashes, eyelids, or conjunctiva with the tip of the eye drop bottle were regarded as "failure". We excluded patients with vision below counting finger. RESULTS: One-hundred and two patients (54 males and 58 females, aged 70.2 ± 12.3 years) with ocular disease who were hospitalized for surgery (cataract: 61.8%, glaucoma: 15.7%, retinal and vitreous diseases: 22.5%) were included in this prospective observational study. The mean duration of eye drop use was 3.1 ± 5.2 years. The success rate of eye drop instillation was significantly higher in the supine position than in the sitting position (64.7% vs. 50%, P = 0.0039). The mean age was significantly higher in the failure group than in the success group (74.0 ± 11.5 vs. 67.7 ± 12.4 years, P = 0.0085) for the sitting position, but not significantly different for the supine position (72.3 ± 12.9 vs. 70.1 ± 12.0 years, P = 0.3849). No significant differences in mean duration of drop use, mean corrected VA, and mean spherical equivalent refraction were observed between success and failure groups, for both sitting and supine positions. CONCLUSIONS: In the present study, the success rate of eye drop instillation was significantly higher when applied in the supine position than in the sitting position.

DOI： 10.1371/journal.pone.0204363

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【網膜硝子体手術アップデート】難治性の黄斑円孔・糖尿病黄斑浮腫に対する手術

塩出雄亮, 森實祐基

眼科グラフィック 6 ( 6 ) 566 - 575 2017年12月

Retinal Nerve Fiber Layer Defect and Paracentral Scotoma after Internal Limiting Membrane Peeling with a Nitinol Loop.

Ryo Matoba, Yuki Morizane, Shuhei Kimura, Shinji Toshima, Fumio Shiraga

Acta medica Okayama 71 ( 6 ) 539 - 542 2017年12月

記述言語：英語

Internal limiting membrane (ILM) peeling is an important maneuver in vitrectomy for macular holes (MHs). A nitinol loop is a surgical instrument designed to create an edge on the ILM and peel the ILM safely and consistently. The effect of using a nitinol loop for ILM peeling on the retina is not clear. We report here on a case of an idiopathic full-thickness MH in an adult woman, in whom retinal damage was revealed after her ILM was peeled using a nitinol loop.

DOI： 10.18926/AMO/55592

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Retinal sensitivity after displacement of submacular hemorrhage due to polypoidal choroidal vasculopathy: effectiveness and safety of subretinal tissue plasminogen activator.

Shuhei Kimura, Yuki Morizane, Ryo Matoba, Mio Hosokawa, Yusuke Shiode, Masayuki Hirano, Shinichiro Doi, Shinji Toshima, Kosuke Takahashi, Mika Hosogi, Atsushi Fujiwara, Fumio Shiraga

Japanese journal of ophthalmology 61 ( 6 ) 472 - 478 2017年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

PURPOSE: To investigate the effectiveness of displacement of submacular hemorrhage (SMH) caused by polypoidal choroidal vasculopathy (PCV) by assessing retinal sensitivity using microperimetry. METHODS: We retrospectively reviewed the medical records of 11 consecutive PCV patients with SMH. All patients underwent vitrectomy, subretinal injection of tissue plasminogen activator, and fluid-air exchange, followed by antivascular endothelial growth factor therapy using a pro re nata regimen. The retinal sensitivity was measured by use of microperimetry before and after surgery. RESULTS: The mean (SD) age of the patients was 74.1 ± 9.4 years. The mean SMH diameter was 6.8 ± 5.2 disc diameters. The best-corrected visual acuity (BCVA), mean retinal sensitivity, and mean number of measure points with a sensitivity ≥10 dB before the surgery were 0.94 ± 0.49, 4.2 ± 4.5 dB, and 15.6 ± 15.1 points, respectively. These had significantly improved 6 months after surgery (0.39 ± 0.37, 15.6 ± 7.3 dB, and 50.9 ± 22.2 points, respectively; P < 0.05 for all outcome measures). The mean number of measure points with an absolute scotoma before surgery had decreased significantly 6 months after surgery (from 40.5 ± 15.0 to 9.4 ± 16.0 points; P < 0.001). CONCLUSIONS: Displacement of SMH effectively improves retinal sensitivity as well as BCVA.

DOI： 10.1007/s10384-017-0530-0

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En face optical coherence tomography画像を用いた分層黄斑円孔の解析

平野雅幸, 森實祐基, 木村修平, 熊瀬文明, 細川海音, 塩出雄亮, 土居真一郎, 戸島慎二, 高橋耕輔, 細木三佳, 藤原篤之, 高須一平, 白神史雄

眼科臨床紀要 10 ( 10 ) 841 - 841 2017年10月

網膜静脈分枝閉塞症の患眼と僚眼にみられる周辺部網膜血管異常と血管閉塞領域との関連

熊瀬文明, 森實祐基, 細木三佳, 木村修平, 細川海音, 塩出雄亮, 平野雅幸, 土居真一郎, 戸島慎二, 高橋耕介, 藤原篤之, 白神史雄

眼科臨床紀要 10 ( 10 ) 855 - 855 2017年10月

中心性漿液性脈絡網膜症の治療前後の脈絡膜厚および脈絡膜血管密度の検討

塩出雄亮, 森實祐基, 木村修平, 熊瀬文明, 細川海音, 平野雅幸, 土居真一郎, 戸島慎二, 高橋耕介, 細木三佳, 藤原篤之, 白神史雄

眼科臨床紀要 10 ( 10 ) 859 - 859 2017年10月

The Role of Inverted Internal Limiting Membrane Flap in Macular Hole Closure. 国際誌

Yusuke Shiode, Yuki Morizane, Ryo Matoba, Masayuki Hirano, Shinichiro Doi, Shinji Toshima, Kosuke Takahashi, Ryoichi Araki, Yuki Kanzaki, Mika Hosogi, Tomoko Yonezawa, Atsushi Yoshida, Fumio Shiraga

Investigative ophthalmology & visual science 58 ( 11 ) 4847 - 4855 2017年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

Purpose: To investigate the mechanism of macular hole (MH) closure following the inverted internal limiting membrane (ILM) technique. Methods: We performed the inverted ILM flap surgical technique as an experimental MH model in monkeys, and investigated the process of MH closure immunohistochemically. We then investigated the effects of type IV collagen, fibronectin, and laminin, which are constituent proteins of the ILM, on the proliferation and migration of cultivated Müller cells (MIO-M1). We also investigated the expression of neurotrophic factors and basic fibroblast growth factor (bFGF) in human ILM and MIO-M1 cells, and the effect of MIO-M1 migration on the expression of these factors, via immunohistochemical staining and the real-time reverse transcription polymerase chain reaction. Results: Ten days after inverted ILM flap surgery, the MH had closed and proliferating glial fibrillary acidic protein (GFAP)-positive cells surrounded the ILM. Type IV collagen, fibronectin, and laminin all enhanced the proliferation of MIO-M1 cells, and type IV collagen and fibronectin enhanced the migration of MIO-M1 cells. Neurotrophic factors and bFGF were present on the surface of the human ILM, and MIO-M1 cells produced these factors. Neurotrophic factors and bFGF were expressed to a significantly greater extent by migrating MIO-M1 cells than by these cells in their static state. Conclusions: During MH closure, the ILM functioned as a scaffold for the proliferation and migration of Müller cells, and may promote Müller cell activation. Neurotrophic factors and bFGF produced by activated Müller cells and present on the surface of the ILM may contribute to MH closure.

DOI： 10.1167/iovs.17-21756

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