研究者詳細 - 森實　祐基

論文 - 森實　祐基

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木村修平, 森實祐基

眼科 65 ( 8 ) 733 - 740 2023年8月

記述言語：日本語出版者・発行元：金原出版(株)

＜文献概要＞黄斑円孔に対して内境界膜(internal limiting membrane:ILM)剥離とガスタンポナーデを併施した硝子体切除が標準術式として行われるようになり,400μm以下の黄斑円孔であれば,ほぼ100%に近い確率で黄斑円孔を閉鎖できるようになった。しかし標準術式では閉鎖が得られにくい難治性の黄斑円孔も存在する。近年,難治性黄斑円孔に対してILM翻転,ILM自家移植,自家感覚網膜移植などの術式が考案され手術成績が報告されている。そこで本稿では,まず標準術式の歴史と問題点について述べ,その後,難治性黄斑円孔に対する術式とその評価について解説する。

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その他リンク： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J00293&link_issn=&doc_id=20230822130009&doc_link_id=10.18888%2Fga.0000003216&url=https%3A%2F%2Fdoi.org%2F10.18888%2Fga.0000003216&type=%E5%8C%BB%E6%9B%B8.jp_%E3%82%AA%E3%83%BC%E3%83%AB%E3%82%A2%E3%82%AF%E3%82%BB%E3%82%B9&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

眼内炎診療における病院総合医の役割

川口満理奈, 大塚勇輝, 副島佳晃, 安藤航, 高木桃李, 大國皓平, 長谷川功, 本多寛之, 萩谷英大, 小比賀美香子, 森田哲郎, 森實祐基, 大塚文男

日本病院総合診療医学会雑誌 19 ( 臨増2 ) 142 - 142 2023年8月

Analysis of temporal changes in thickness from conjunctiva to sclera after plication of the medial rectus muscle measured by anterior segment optical coherence tomography 査読

Takehiro Shimizu, Ichiro Hamasaki, Kiyo Shibata, Shin Morisawa, Reika Kono, Keisuke Kanenaga, Yuki Morizane

Japanese Journal of Ophthalmology 67 ( 5 ) 612 - 617 2023年6月

OCT En face画像を用いた糖尿病黄斑浮腫の分類と黄斑上膜の合併率

森實祐基, 藤原篤之, 神崎勇希, 木村修平, 細川海音, 塩出雄亮, 土居真一郎, 的場亮

日本糖尿病眼学会誌 27 116 - 116 2023年5月

A factor for predicting simultaneous internal limiting membrane peeling during epiretinal membrane removal: swept-source optical coherence tomography-based evaluation of epiretinal membrane adhesion to the retina.

Ryo Matoba, Yuki Kanzaki, Shuhei Kimura, Mio M Hosokawa, Yusuke Shiode, Tetsuro Morita, Yuki Morizane

Japanese journal of ophthalmology 2023年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

PURPOSE: To investigate preoperative factors associated with simultaneous internal limiting membrane (ILM) peeling during epiretinal membrane (ERM) removal. STUDY DESIGN: Observational cross-sectional study. METHODS: We retrospectively reviewed 60 eyes with idiopathic ERM that underwent vitrectomy. The gap between the ERM and ILM was visualized using en face optical coherence tomography. The depth and width of the ERM-ILM gap at the initiation site of ERM removal were measured, and the relationship between preoperative factors including these parameters and simultaneous ILM peeling during ERM removal was investigated. RESULTS: The ILM was simultaneously peeled during ERM removal in 30 eyes, but not in the other 30 eyes. Age was significantly higher (P = 0.017) and the width of the ERM-ILM gap was significantly smaller (P < 0.001) in the simultaneous ILM peeling (+) group than in the simultaneous ILM peeling (-) group. Multivariate logistic regression analysis confirmed the width of the ERM-ILM gap as a significant negative predictor for simultaneous ILM peeling (odds ratio, 0.992; 95% confidence interval, 0.986-0.997; P = 0.003). Receiver operating characteristic curve analysis of the width of the ERM-ILM gap revealed that the optimal cutoff for predicting simultaneous ILM peeling was 187.1 µm. CONCLUSION: The small width of the ERM-ILM gap at the initiation site of ERM removal was significantly associated with simultaneous ILM peeling, indicating that the adhesion strength between the ERM and ILM at the initial ERM grasping site determines whether simultaneous ILM peeling will occur during ERM removal.

DOI： 10.1007/s10384-023-00993-w

PubMed

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A nationwide survey of newly certified visually impaired individuals in Japan for the fiscal year 2019: impact of the revision of criteria for visual impairment certification.

Ryo Matoba, Noriko Morimoto, Ryo Kawasaki, Miyuki Fujiwara, Keisuke Kanenaga, Hidetoshi Yamashita, Taiji Sakamoto, Yuki Morizane

Japanese journal of ophthalmology 2023年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

PURPOSE: To determine the status of visual impairment certification in Japan in the fiscal year 2019 and the impact of revising the criteria for visual impairment certification implemented in 2018. STUDY DESIGN: Observational cross-sectional study. METHODS: We requested welfare offices throughout Japan to submit data of age, sex, causative diseases, and visual impairment grades for newly certified visually impaired individuals aged ≥ 18 years during the fiscal year 2019. The certification was based on criteria of the Act on Welfare of Physically Disabled Persons. RESULTS: Altogether, data were collected for 16,504 newly certified visually impaired individuals. The most common age group was 80-89 years (29.6%), followed by 70-79 (28.2%) and 60-69 (15.3%) years. The most common causative disease was glaucoma (40.7%), followed by retinitis pigmentosa (13.0%), diabetic retinopathy (10.2%), and macular degeneration (9.1%). The most common impairment grade was grade 2 (40.8%), followed by 5 (21.2%) and 1 (17.0%). Compared to the fiscal year 2015, there was a considerable increase in the number of individuals certified with glaucoma in the fiscal year 2019. Moreover, there was a significant increase in the number of individuals with certified grades 1 and 2 visual impairment, with a decrease in the number of individuals with certified grade 6 visual impairment. CONCLUSION: The changes revealed in this study were primarily due to the revised certification criteria implemented in July 2018, indicating that it is important to review the certification criteria and to repeat surveys similar to the present study.

DOI： 10.1007/s10384-023-00986-9

PubMed

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Epiretinal Membrane Impairs the Inner Retinal Layer in a Traction Force-Dependent Manner

Yuki Kanzaki, Ryo Matoba, Shuhei Kimura, Mio M. Hosokawa, Yusuke Shiode, Shinichiro Doi, Tetsuro Morita, Sayumi Kanzaki, Ippei Takasu, Atsuhiro Tanikawa, Yuki Morizane

Ophthalmology Science 100312 - 100312 2023年4月

Quantitative analyses of retinal traction force and metamorphopsia in lamellar macular hole and related diseases

Mai Mino, Ryo Matoba, Yuki Kanzaki, Shuhei Kimura, Mio M. Hosokawa, Yusuke Shiode, Tetsuro Morita, Yuki Morizane

Ophthalmology Science 100305 - 100305 2023年4月

Impact of macular intraretinal hemorrhage and macular hole on the visual prognosis of submacular hemorrhage due to retinal arterial macroaneurysm rupture 査読国際誌

Shinichiro Doi, Shuhei Kimura, Shoko Saito, Makoto Inoue, Toshiya Sakurai, Akira Kobori, Toshio Hisatomi, Hisanori Imai, Shoji Kuriyama, Ippei Takasu, Mio Morizane Hosokawa, Yusuke Shiode, Ryo Matoba, Etsuji Suzuki, Yuki Morizane

Retina 43 ( 4 ) 585 - 593 2023年4月

黄斑下出血を合併したILM下出血に対するILM整復法の術後経過に網膜内出血が及ぼす影響

木村修平, 細川海音, 塩出雄亮, 的場亮, 神崎勇希, 森田哲郎, 森實祐基

日本眼科学会雑誌 127 ( 臨増 ) 256 - 256 2023年3月

OCTを用いた分層黄斑円孔と類縁疾患の多面的解析

的場亮, 神崎勇希, 木村修平, 細川海音, 塩出雄亮, 森實祐基

日本眼科学会雑誌 127 ( 臨増 ) 242 - 242 2023年3月

急速に網膜外層の障害を来した両眼性網膜症の1例

金道寛弥, 塩出雄亮, 木村修平, 細川海音, 的場亮, 森田哲郎, 森實祐基

日本眼科学会雑誌 127 ( 臨増 ) 283 - 283 2023年3月

術後性上顎嚢胞が原因と考えられた前部ぶどう膜炎の1例

今村勇太, 塩出雄亮, 金道寛弥, 木村修平, 細川海音, 的場亮, 森田哲郎, 森實祐基

日本眼科学会雑誌 127 ( 臨増 ) 268 - 268 2023年3月

【日本の眼の難病-何がどこまでわかってきたのか?】視覚身体障害者の疫学

的場亮, 森實祐基

臨床眼科 77 ( 1 ) 86 - 90 2023年1月

記述言語：日本語出版者・発行元：(株)医学書院

＜文献概要＞●視覚障害の原因疾患の第1位が緑内障,第2位が網膜色素変性,第3位が糖尿病網膜症であった。●緑内障を原因とする視覚障害者は高齢であり,障害等級が高かった。●都道府県別の認定者割合は高齢化率および眼科指定医師数と有意に関連した。

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その他リンク： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J01537&link_issn=&doc_id=20221229100015&doc_link_id=10.11477%2Fmf.1410214687&url=https%3A%2F%2Fdoi.org%2F10.11477%2Fmf.1410214687&type=%E5%8C%BB%E6%9B%B8.jp_%E3%82%AA%E3%83%BC%E3%83%AB%E3%82%A2%E3%82%AF%E3%82%BB%E3%82%B9&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

Protrusion of KCNJ13 Gene Knockout Retinal Pigment Epithelium Due to Oxidative Stress-Induced Cell Death. 国際誌

Yuki Kanzaki, Hirofumi Fujita, Keita Sato, Mio Hosokawa, Hiroshi Matsumae, Yuki Morizane, Hideyo Ohuchi

Investigative ophthalmology & visual science 63 ( 12 ) 29 - 29 2022年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

PURPOSE: This study was performed to elucidate the mechanisms of morphological abnormalities in a Leber congenital amaurosis 16 (LCA16) cell model using KCNJ13 knockout (KO) retinal pigment epithelial cells derived from human iPS cells (hiPSC-RPE). METHODS: In KCNJ13 KO and wild-type hiPSC-RPE cells, ZO-1 immunofluorescence was performed, and confocal images were captured. The area and perimeter of each cell were measured. To detect cell death, ethidium homodimer III (EthD-III) staining and LDH assay were used. Scanning electron microscopy (SEM) was used to observe the cell surface. The expression levels of oxidative stress-related genes were examined by quantitative PCR. To explore the effects of oxidative stress, tert-butyl hydroperoxide (t-BHP) was administered to the hiPSC-RPE cells. Cell viability was tested by MTS assay, whereas oxidative damage was monitored by oxidized (GSSG) and reduced glutathione levels. RESULTS: The area and perimeter of KCNJ13-KO hiPSC-RPE cells were enlarged. EthD-III-positive cells were increased with more dead cells in the protruded region. The KO RPE had significantly higher LDH levels in the medium. SEM observations revealed aggregated cells having broken cell surfaces on the KO RPE sheet. The KCNJ13-deficient RPE showed increased expression levels of oxidative stress-related genes and total glutathione levels. Furthermore, t-BHP induced a significant increase in cell death and GSSG levels in the KO RPE. CONCLUSIONS: We suggest that in the absence of the Kir.7.1 potassium channel, human RPE cells are vulnerable to oxidative stress and ultimately die. The dying/dead cells form aggregates and protrude from the surviving KCNJ13-deficient RPE sheet.

DOI： 10.1167/iovs.63.12.29

PubMed

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【いま知っておくべき注目の病態名】Epiretinal proliferation(EP)

的場亮, 森實祐基

Retina Medicine 11 ( 2 ) 131 - 135 2022年10月

記述言語：日本語出版者・発行元：(株)先端医学社

Epiretinal proliferation(EP)は網膜表面にみられる牽引力に乏しい黄白色の膜状組織であり,おもに網膜内層から遊走したMueller細胞からなる.EPは分層黄斑円孔で高率に認められるが,黄斑円孔,黄斑上膜などにおいてもみられる.近年,分層黄斑円孔に対してEPを埋め込む術式の有効性が報告されている.(著者抄録)

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強膜バックリング後に形成された黄斑上膜の検討:OCT en face画像を用いた解析

的場亮, 神崎勇希, 木村修平, 細川海音, 塩出雄亮, 土居真一郎, 森實祐基

眼科臨床紀要 15 ( 10 ) 691 - 692 2022年10月

Graft Size and Double Scroll Formation Rate in Descemet Membrane Endothelial Keratoplasty. 国際誌

Hiroshi Matsumae, Takefumi Yamaguchi, Yuki Kusano, Shigeto Shimmura, Akira Kobayashi, Yuki Morizane, Jun Shimazaki

Current eye research 47 ( 9 ) 1246 - 1251 2022年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

PURPOSE: This study aimed to evaluate the usefulness of intentional double scroll formation of donor Descemet membrane (DM) inside a glass tube inserter (the Fogla technique) in DM endothelial keratoplasty (DMEK) for controlled insertion and unfolding of grafts. METHODS: Eleven consecutive patients who underwent DMEK were included in this study. We sought to specify graft characteristics in which double scroll configuration was successfully formed using the Fogla technique. We compared donor age, graft size, surgical time, unfolding time, and visual outcomes between patients with and without double scroll configuration. The ability to form double scroll formation of DM grafts of various diameters and unfolding time of DM grafts was evaluated using total seven eye-bank eyes in ex vivo experiments. RESULTS: A double scroll configuration inside a glass tube was successfully obtained in six DMEK grafts (54.5%). When comparing clinical features between those with and without double scroll configuration, only graft size was significantly larger in those with double scroll configuration (7.9 ± 0.2 mm) than in those without (7.4 ± 0.4, P = 0.03). There were no significant differences in other features and clinical outcomes, although unfolding-time was shorter in eyes with double scroll configuration (4.6 ± 2.0 min) compared to those without (8.6 ± 8.1, P = 0.21). Ex vivo experiments showed that unfolding time was significantly shorter in double scroll configuration (2.71 ± 0.49 min) than in single scroll (5.02 ± 0.79, P = 0.01). CONCLUSIONS: A double scroll configuration within a glass tube can be obtained more frequently in larger DMEK grafts (8.0 mm in diameter), which may result in easier and faster DMEK procedures.

DOI： 10.1080/02713683.2022.2104318

PubMed

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糖尿病黄斑浮腫に対する抗VEGF薬の治療効果に黄斑上膜の合併が及ぼす影響

神崎勇希, 細川海音, 木村修平, 塩出雄亮, 的場亮, 森田哲郎, 森實祐基

糖尿病合併症 36 ( Suppl.1 ) 238 - 238 2022年9月

糖尿病黄斑浮腫に対する抗VEGF薬の治療効果に黄斑上膜の合併が及ぼす影響

神崎勇希, 細川海音, 木村修平, 塩出雄亮, 的場亮, 森田哲郎, 森實祐基

糖尿病合併症 36 ( Suppl.1 ) 238 - 238 2022年9月

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