Organization
Faculty of Environmental, Life, Natural Science and Technology Professor
Position
Professor
External link
KIMURA Yukitaka
Degree
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Doctor of Agriculture ( Kyoto University )
Research Interests
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Slug Flow
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Subcritical Water
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食品工学
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Chemical Process Engineering
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Environmental Process Engineering
Research Areas
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Environmental Science/Agriculture Science / Environmental materials and recycle technology / 環境プロセス工学
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Life Science / Bioorganic chemistry
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Life Science / Food sciences
Education
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Kyoto University 農学研究科 食品工学
- 1990
Country： Japan
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Kyoto University
- 1990
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Kyoto University 農学部 食品工学科
- 1985
Country： Japan
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Kyoto University
- 1985
Research History
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Okayama University 学術研究院環境生命科学学域（工） Professor
2021.4
Country：Japan
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Okayama University The Graduate School of Environmental and Life Science Professor
2012.4 - 2021.3
Country：Japan
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Okayama University 大学院環境学研究科 Professor
2008.10 - 2012.3
Country：Japan
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- 京都大学大学院農学研究科助教授 准教授
2003.11 - 2008.9
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文部省在外研究員としてスウェ－デンウプサラ大学で研究
1995 - 1996
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Kyoto University Faculty of Agriculture
1990 - 2003
Professional Memberships
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生物工学会
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石油学会
2015.6
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日本食品工学会
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化学工学会
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農芸化学会
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日本化学会
Committee Memberships
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生物工学会 編集委員
1998
Papers
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Toshinori Shimanouchi, Daichi Hirota, Masafumi Yoshida, Kazuma Yasuhara, Yukitaka Kimura
Applied Sciences 14 ( 23 ) 11326 - 11326 2024.12
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Toshinori SHIMANOUCHI, Sota SANAGI, Satoko FUJIOKA, Koichi TERASAKA, Yukitaka KIMURA
Solvent Extraction Research and Development, Japan 31 ( 2 ) 67 - 75 2024
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Classification of binding property of amyloid β to lipid membranes: Membranomic research using quartz crystal microbalance combined with the immobilization of lipid planar membranes. Reviewed International journal
Toshinori Shimanouchi, Miki Iwamura, Yasuhiro Sano, Keita Hayashi, Minoru Noda, Yukitaka Kimura
Biochimica et biophysica acta. Proteins and proteomics 1872 ( 3 ) 140987 - 140987 2023.12
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Hydrothermal Preparation of Faceted Vesicles Made of Span 40 and Tween 40 and Their Characterization Reviewed
Toshinori Shimanouchi, Yui Komori, Kazuki Toramoto, Keita Hayashi, Kazuma Yasuhara, Ho Sup Jung, Yukitaka Kimura
Applied Sciences (Switzerland) 13 ( 12 ) 2023.6
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Conversion of Glycerol to Lactic Acid by Using Platinum-supported Catalyst Combined with Phosphatidylcholine Vesicles Reviewed
Toshinori Shimanouchi, Yuki Takahashi, Kazuma Yasuhara, Yukitaka Kimura
Chemistry Letters 52 ( 6 ) 426 - 429 2023
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Toshinori Shimanouchi, Yuki Takahashi, Keita Hayashi, Kazuma Yasuhara, Yukitaka Kimura
Compounds 2 ( 4 ) 321 - 333 2022.11
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Amyloid-β aggregates induced by β-cholesteryl glucose-embedded liposomes Reviewed
Toshinori Shimanouchi, Yasuhiro Sano, Kazuma Yasuhara, Yukitaka Kimura
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1870 ( 8 ) 140816 - 140816 2022.8
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Microfluidic and hydrothermal preparation of vesicles using sorbitan monolaurate/polyoxyethylene (20) sorbitan monolaurate (Span 20/Tween 20) Reviewed
Toshinori Shimanouchi, Tetsuya Hayashi, Kazuki Toramoto, Saki Fukuma, Keita Hayashi, Kazuma Yasuhara, Yukitaka Kimura
Colloids and Surfaces B: Biointerfaces 205 2021.9
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Fibril growth behavior of amyloid β on polymer-based planar membranes: Implications for the entanglement and hydration of polymers Reviewed
Toshinori Shimanouchi, Miki Iwamura, Shintaro Deguchi, Yukitaka Kimura
Applied Sciences (Switzerland) 11 ( 10 ) 2021.5
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Characterization of water/organic biphasic system in liquid-liquid slug flow under hydrothermal conditions: Solvation, vorticity, and hydrophobicity Reviewed
Toshinori Shimanouchi, Satoko Fujioka, Tatsuya Tanifuji, Kenta Yamamoto, Koichi Terasaka, Yukitaka Kimura
Solvent Extraction Research and Development 28 ( 1 ) 21 - 35 2021
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Analysis of the Partitioning Behavior of Horseradish Peroxidase to Phospholipid and Surfactant Membranes Reviewed
Saki Fukuma, Toshinori Shimanouchi, Kazuma Yasuhara, Yukitaka Kimura
Solvent Extraction Research and Development 27 ( 2 ) 113 - 213 2020
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Application of liposome membrane as the reaction field: A case study using the Horner–Wadsworth–Emmons reaction Reviewed
Toshinori Shimanouchi, Yuki Kitagawa, Yukitaka Kimura
Journal of Bioscience and Bioengineering 128 ( 2 ) 198 - 202 2019.8
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Temperature Measurement by Sublimation Rate as a Process Analytical Technology Tool in Lyophilization Reviewed
Hidenori Kawasaki, Toshinori Shimanouchi, Hiroyuki Sawada, Hiroshi Hosomi, Yuta Hamabe, Yukitaka Kimura
Journal of Pharmaceutical Sciences 108 ( 7 ) 2305 - 2314 2019.7
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Recent Development of Optimization of Lyophilization Process Reviewed
Hidenori Kawasaki, Toshinori Shimanouchi, Yukitaka Kimura
Journal of Chemistry 2019 2019
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Kinetic pH Titration to Predict the Acid and Hydrothermal Conditions for the Hydrolysis of Disaccharides: Use of a Microcapillary System Reviewed
Toshinori Shimanouchi, Ryota Mano, Yu Yoshioka, Ayaka Fukuda, Kyung Min Park, Yukitaka Kimura
Journal of Chemistry 2019 2019
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Scale-up procedure for primary drying process in lyophilizer by using the vial heat transfer and the drying resistance Reviewed
Hidenori Kawasaki, Toshinori Shimanouchi, Masaharu Yamamoto, Kanako Takahashi, Yukitaka Kimura
Chemical and Pharmaceutical Bulletin 66 ( 11 ) 1048 - 1056 2018
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Effect of controlled nucleation of ice crystals on the primary drying stage during lyophilization Reviewed
Hidenori Kawasaki, Toshinori Shimanouchi, Kanako Takahashi, Yukitaka Kimura
Chemical and Pharmaceutical Bulletin 66 ( 12 ) 1122 - 1130 2018
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Indocyanine green-laden poly(ethylene glycol)-block-polylactide (PEG-b-PLA) nanocapsules incorporating reverse micelles: Effects of PEG-b-PLA composition on the nanocapsule diameter and encapsulation efficiency Reviewed
Takaichi Watanabe, Yui Sakamoto, Tetsuya Inooka, Yukitaka Kimura, Tsutomu Ono
Colloids and Surfaces A: Physicochemical and Engineering Aspects 520 764 - 770 2017.5
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Effect of wet and dry torrefaction process on fuel properties of solid fuels derived from bamboo and Japanese cedar Reviewed
Wei Yang, Shengji Wu, Hui Wang, Pengyu Ma, Toshiniri Shimanouchi, Yukitaka Kimura, Jie Zhou
BioResources 12 ( 4 ) 8629 - 8640 2017
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Calcein leakage behavior from vesicles induced by proteinvesicle interaction: A study by surface pressurearea isotherms Reviewed
Saki Fukuma, Toshinori Shimanouchi, Keita Hayashi, Yukitaka Kimura
Chemistry Letters 46 ( 7 ) 1036 - 1039 2017
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Chemical conversion and liquid-liquid extraction of 5-hydroxymethylfurfural from fructose by slug flow microreactor Reviewed
Toshinori Shimanouchi, Yoshitaka Kataoka, Tatsuya Tanifuji, Yukitaka Kimura, Satoko Fujioka, Koichi Terasaka
AIChE Journal 62 ( 6 ) 2135 - 2143 2016.6
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Surface properties of woody thin boards composed of commercially available lignin and cellulose: Relationship between the orientation of lignin and water repellency Reviewed
Toshinori Shimanouchi, Tomoya Kamba, Wei Yang, Satoka Aoyagi, Yukitaka Kimura
Applied Surface Science 347 406 - 413 2015.8
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Elevating the fuel properties of Humulus lupulus, Plumeria alba and Calophyllum inophyllum L. through wet torrefaction Reviewed
Wei Yang, Toshinori Shimanouchi, Miki Iwamura, Yuki Takahashi, Ryota Mano, Kohei Takashima, Tatsuya Tanifuji, Yukitaka Kimura
Fuel 146 88 - 94 2015.4
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Characterization of the residue and liquid products produced from husks of nuts from carya cathayensis sarg by hydrothermal carbonization Reviewed
Wei Yang, Toshinori Shimanouchi, Yukitaka Kimura
ACS Sustainable Chemistry and Engineering 3 ( 4 ) 591 - 598 2015.4
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Influence of sugar surfactant structure on the encapsulation of oil droplets in an amorphous sugar matrix during freeze-drying Reviewed
S. Nakayama, Y Kimura, S. Miki, J. Oshitani, T. Kobayashi, S. Adachi, T. Matsuura, H. Imanaka, N. Ishida, H. Tada, K. Nakanishi, K. Imamura
Food Research International 70 143 - 149 2015.4
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Characterization of hydrochar prepared from hydrothermal carbonization of peels of Carya cathayensis sarg Reviewed
Wei Yang, Toshinori Shimanouchi, Yukitaka Kimura
Desalination and Water Treatment 53 ( 10 ) 2831 - 2838 2015.3
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Preparation of biodegradable foam from walnut shells treated by subcritical water Reviewed
Wei Yang, Ichiro Shimizu, Tsutomu Ono, Yukitaka Kimura
Journal of Chemical Technology and Biotechnology 90 ( 1 ) 44 - 49 2015.1
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Investigation of the degradation kinetic parameters and structure changes of microcrystalline cellulose in subcritical water Reviewed
Wei Yang, Toshinori Shimanouchi, Shengji Wu, Yukitaka Kimura
Energy and Fuels 28 ( 11 ) 6974 - 6980 2014.11
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Extraction of reducing sugar with anti-oxidative scavengers from peels of Carya cathayensis sarg.: Use of subcritical water Reviewed
Toshinori Shimanouchi, Shohei Ueno, Wei Yang, Yukitaka Kimura
Environmental Engineering Research 19 ( 1 ) 41 - 45 2014.3
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Monodisperse polylactide microcapsules with a single aqueous core prepared via spontaneous emulsification and solvent diffusion Reviewed
Takaichi Watanabe, Yukitaka Kimura, Tsutomu Ono
RSC Advances 4 ( 10 ) 4872 - 4877 2014
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Water / Methyl isobutyl ketone (MIBK) biphasic system in slug flow under high temperature and pressure conditions Reviewed
Toshinori Shimanouchi, Tatsuya Tanifuji, Satoko Fujioka, Koichi Terasaka, Yukitaka Kimura
Solvent Extraction Research and Development 21 ( 2 ) 201 - 209 2014
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Subcritical water-Assisted emulsification of oil/water: The effect of the solubility of the organic solvent and surfactants Reviewed
Toshinori Shimanouchi, Takashi Tange, Yukitaka Kimura
Solvent Extraction Research and Development 21 ( 2 ) 223 - 230 2014
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Subcritical water-assisted emulsification of decane/water: Influence of surfactants Reviewed
Toshinori Shimanouchi, Takashi Tange, Yukitaka Kimura
Solvent Extraction Research and Development 21 ( 1 ) 103 - 110 2014
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Rapid conversion of glycerol to lactic acid under alkaline hydrothermal conditions, by using a continuous flow reaction system Reviewed
Toshinori Shimanouchi, Shouhei Ueno, Kazuki Shidahara, Yukitaka Kimura
Chemistry Letters 43 ( 4 ) 535 - 537 2014
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Microfluidic fabrication of monodisperse polylactide microcapsules with tunable structures through rapid precipitation Reviewed
Takaichi Watanabe, Yukitaka Kimura, Tsutomu Ono
Langmuir 29 ( 46 ) 14082 - 14088 2013.11
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Simplified model for extraction of 5-hydroxymethylfurfural from fructose: Use of water/oil biphasic system under high temperature and pressure conditions Reviewed
Toshinori Shimanouchi, Yoshitaka Kataoka, Masahiro Yasukawa, Tsutomu Ono, Yukitaka Kimura
Solvent Extraction Research and Development 20 205 - 212 2013
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Absorption of the indigestible disaccharide, β-1,4-mannobiose, from coconut by the Rat Portal Vein Reviewed
Hiroyuki Kanatani, Yukitaka Kimura, Masashi Asanoma, Akihiro Nakamura, Motohiko Hirotsuka, Shuji Adachi
Bioscience, Biotechnology and Biochemistry 76 ( 3 ) 575 - 577 2012
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Continuous fabrication of monodisperse polylactide microspheres by droplet-to-particle technology using microfluidic emulsification and emulsion-solvent diffusion Reviewed
Takaichi Watanabe, Tsutomu Ono, Yukitaka Kimura
Soft Matter 7 ( 21 ) 9894 - 9897 2011.11
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Decomposition and discoloration kinetics of L-ascorbic acid powders in superheated steam Reviewed
Yuka Horagai, Lan-hsin Hung, Yukitaka Kimura, Shuji Adachi
LWT-FOOD SCIENCE AND TECHNOLOGY 41 ( 10 ) 2113 - 2117 2008.12
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Synthesis of glyceryl ferulate by immobilized ferulic acid esterase Reviewed
Takemasa Matsuo, Takashi Kobayashi, Yukitaka Kimura, Moriyasu Tsuchiyama, Tadanobu Oh, Tatsuji Sakamoto, Shuji Adachi
BIOTECHNOLOGY LETTERS 30 ( 12 ) 2151 - 2156 2008.12
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Thermal Stability of Immobilized Lipase from Candida antarctica in Glycerols with Various Water Contents at Elevated Temperatures Reviewed
Takashi Kobayashi, Takemasa Matsuo, Yukitaka Kimura, Shuji Adachi
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY 85 ( 11 ) 1041 - 1044 2008.11
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Properties of Extracts from Wheat Bran by Subcritical Water Treatment Reviewed
Kataoka, Masaaki, Wiboonsirikul, Jintana, Kimura, Yukitaka, Adachi, Shuji
FOOD SCIENCE AND TECHNOLOGY RESEARCH 14 ( 6 ) 553 - 556 2008.11
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HUNG Lan‐hsin, KIMURA Yukitaka, ADACHI Shuji
日本食品工学会誌 9 ( 3 ) 135 - 141 2008.9
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Effects of sodium chloride on the degradation of hexoses and the hydrolysis of sucrose in subcritical water Reviewed
Jin Ohshima, Shabnam Haghighat Khajavi, Yukitaka Kimura, Shuji Adachi
EUROPEAN FOOD RESEARCH AND TECHNOLOGY 227 ( 3 ) 799 - 803 2008.7
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Extraction of defatted rice bran by subcritical water treatment Reviewed
Shigeru Hata, Jintana Wiboonsirikul, Atsushi Maeda, Yukitaka Kimura, Shuji Adachi
Biochemical Engineering Journal 40 ( 1 ) 44 - 53 2008.5
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Production and characterization of functional substances from a by-product of rice bran oil and protein production by a compressed hot water treatment Reviewed
Jintana Wiboonsirikul, Yukitaka Kimura, Yumi Kanaya, Takuo Tsuno, Shuji Adachi
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 72 ( 2 ) 384 - 392 2008.2
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Degradation of Pentoses and Hexouronic Acids in Subcritical Water Reviewed
USUKI Chisako, KIMURA Yukitaka, ADACHI Shuji
Chem Eng Technol 31 ( 1 ) 133 - 137 2008.1
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Mutagenicity of the Extract from Defatted Rice Bran by Subcritical Water Treatment Reviewed
Jintana Wiboonsirikul, Yukitaka Kimura, Shuji Adachi, Yukihiro Sakai, Asao Hosoda, Hisaji Taniguchi, Hisahiro Morita, Takuo Tsuno
Japan Journal of Food Engineering 9 ( 1 ) 75 - 78 2008
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Production of functional substances from black rice bran by its treatment in subcritical water Reviewed
Jintana Wiboonsirikul, Shigeru Hata, Takuo Tsuno, Yukitaka Kimura, Shuji Adachi
LWT - Food Science and Technology 40 ( 10 ) 1732 - 1740 2007.12
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Decomposition and discoloration of L-ascorbic acid freeze-dried with saccharides Reviewed
Lan-hsin Hung, Yuka Horagai, Yukitaka Kimura, Shuji Adachi
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES 8 ( 4 ) 500 - 506 2007.12
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Properties of extracts from defatted rice bran by its subcritical water treatment Reviewed
Jintana Wiboonsirikul, Yukitaka Kimura, Megumi Kadota, Hisahiro Morita, Takuo Tsuno, Shuji Adachi
Journal of Agricultural and Food Chemistry 55 ( 21 ) 8759 - 8765 2007.10
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Isomerization of hexoses in subcritical water Reviewed
Chisako Usuki, Yukitaka Kimura, Shuji Adachi
FOOD SCIENCE AND TECHNOLOGY RESEARCH 13 ( 3 ) 205 - 209 2007.8
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Discoloration kinetics of L-ascorbyl 6-palmitate powders with various water contents Reviewed
Lan-Hsin Hung, Yukitaka Kimura, Shuji Adachi
FOOD SCIENCE AND TECHNOLOGY RESEARCH 13 ( 1 ) 7 - 12 2007.2
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Production Optimization of the Extract with High Phenolic Content and Radical Scavenging Activity from Defatted Rice Bran by Subcritical Water Treatment Reviewed
Jintana Wiboonsirikul, Pramote Khuwijitjaru, Yukitaka Kimura, Hisahiro Morita, Takuo Tsuno, Shuji Adachi
NIHON SHOKUHIN KOUGAKUKAISHI (Japan Journal of Food Engineering) 8 ( 4 ) 311 - 315 2007
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Surface activities of monoacyl trehaloses in aqueous solution Reviewed
Jie Chen, Yukitaka Kimura, Shuji Adachi
LWT-FOOD SCIENCE AND TECHNOLOGY 40 ( 3 ) 412 - 417 2007
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Continuous preparation of O/W nano-emulsion by the treatment of a coarse emulsion under subcritical water conditions Reviewed
Seiko Katagi, Yukitaka Kimura, Shuji Adachi
LWT-FOOD SCIENCE AND TECHNOLOGY 40 ( 8 ) 1376 - 1380 2007
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Production of functional materials from defatted rice bran by its subcritical water treatment
Wiboonsirikul Jintana, Kimura Yukitaka, Hisahiro Morita, Tsuno Takuo, Adachi Shuji
2007 772 - 772 2007
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Thermal stability of immobilized lipase in n-alcohol - Abstracts
Yayoi Yoshida, Yukitaka Kimura, Shuji Adachi
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC 42 ( 3-4 ) 120 - 121 2006.11
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Hydrolysis kinetics of trisaccharides consisting of glucose, galactose, and fructose residues in subcritical water Reviewed
Shabnam Haghighat Khajavi, Shuji Ota, Risa Nakazawa, Yukitaka Kimura, Shuji Adachi
BIOTECHNOLOGY PROGRESS 22 ( 5 ) 1321 - 1326 2006.10
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Continuous synthesis of alkyl ferulate by immobilized Candida antarctica lipase at high temperature Reviewed
Yayoi Yoshida, Yukitaka Kimura, Megumi Kadota, Takuo Tsuno, Shuji Adachi
Biotechnology Letters 28 ( 18 ) 1471 - 1474 2006.9
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Oxidation of linoleoyl residue of its trehalose ester in an aqueous solution Reviewed
Jie Chen, Yukitaka Kimura, Shuji Adachi
FOOD SCIENCE AND TECHNOLOGY RESEARCH 12 ( 3 ) 163 - 166 2006.8
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Thermal inactivation of immobilized lipase in 1-alcohols Reviewed
Yayoi Yoshida, Yukitaka Kimura, Shuji Adachi
Journal of Bioscience and Bioengineering 102 ( 1 ) 66 - 68 2006.7
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Oral administration of insulin included in fine W/O/W emulsions to rats Reviewed
M Shima, M Tanaka, T Fujii, K Egawa, Y Kimura, S Adachi, R Matsuno
FOOD HYDROCOLLOIDS 20 ( 4 ) 523 - 531 2006.6
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Conversion of Linoleic Acid to Its Conjugated Isomers in Subcritical Water Reviewed
USUKI Chisako, KIMURA Yukitaka, ADACHI Shuji
Japan Journal of Food Engineering 7 ( 2 ) 147 - 150 2006.6
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Kinetics of maltooligosaccharide hydrolysis in subcritical water Reviewed
Shabnam Haghighat Khajavi, Shuji Ota, Yukitaka Kimura, Shuji Adachi
Journal of Agricultural and Food Chemistry 54 ( 10 ) 3663 - 3667 2006.5
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Decomposition kinetics of monoacyl glycerol and fatty acid in subcritical water under temperature-programmed heating conditions Reviewed
T Fujii, P Khuwijitjaru, Y Kimura, S Adachi
FOOD CHEMISTRY 94 ( 3 ) 341 - 347 2006.2
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Haghighat_Khajavi Shabnam, 大嶌 臣, 中澤 梨沙, 木村 幸敬, 安達 修二
化学工学会 研究発表講演要旨集 2006 414 - 414 2006
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Hydrolysis of oligosaccharides in subcritical water
Shuji Adachi, Shabnam Haghighat Khajavi, Shuji Ota, Risa Nakazawa, Yukitaka Kimura
CHISA 2006 - 17th International Congress of Chemical and Process Engineering 2006
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Condensation reaction between angiotensin II and dicarboxylic acid in water at high temperature without any catalytic agent additive Reviewed
Takamitsu Asano, Atsushi Maeda, Yukitaka Kimura, Taro Takahashi, Akihiro Nakamura, Hirokazu Maeda, Shuji Adachi
Biotechnology Progress 21 ( 4 ) 1169 - 1174 2005.7
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Degradation kinetics of monosaccharides in subcritical water Reviewed
Shabnam Haghighat Khajavi, Yukitaka Kimura, Toshinobu Oomori, Ryuichi Matsuno, Shuji Adachi
Journal of Food Engineering 68 ( 3 ) 309 - 313 2005.6
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Kinetics on sucrose decomposition in subcritical water Reviewed
Shabnam Haghighat Khajavi, Yukitaka Kimura, Toshinobu Oomori, Ryuichi Matsuno, Shuji Adachi
LWT - Food Science and Technology 38 ( 3 ) 297 - 302 2005.5
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Enhancement in transport of a hydrophilic marker through intestinal epithelial cell (Caco-2) monolayer by W/O/W multiple emulsion containing C8TG Reviewed
M Shima, M Tanaka, Y Kimura, S Adachi, R Matsuno
FOOD HYDROCOLLOIDS 19 ( 2 ) 321 - 328 2005.3
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Continuous synthesis of 6-O-linoleoyl hexose using a packed-bed reactor system with immobilized lipase Reviewed
Jie Chen, Yukitaka Kimura, Shuji Adachi
Biochemical Engineering Journal 22 ( 2 ) 145 - 149 2005.1
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Synthesis of linoleoyl disaccharides through lipase-catalyzed condensation and their surface activities Reviewed
Jie Chen, Yukitaka Kimura, Shuji Adachi
Journal of Bioscience and Bioengineering 100 ( 3 ) 274 - 279 2005
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Kinetics of Moisture-induced-discoloration of L-Ascorbic Acid Powders Reviewed
Lan-hsin Hung, Yukitaka Kimura, Shuji Adachi
NIHON SHOKUHIN KOUGAKUKAISHI (Japan Journal of Food Engineering) 6 ( 4 ) 289 - 296 2005
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Preparation of finely dispersed O/W emulsion from fatty acid solubilized in subcritical water
P Khuwijitjaru, Y Kimura, R Matsuno, S Adachi
JOURNAL OF COLLOID AND INTERFACE SCIENCE 278 ( 1 ) 192 - 197 2004.10
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Solubility of oleic and linoleic acids in subcritical water Reviewed
Pramote Khuwijitjaru, Yukitaka Kimura, Ryuichi Matsuno, Shuji Adachi
Food Science and Technology Research 10 ( 3 ) 261 - 263 2004.8
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Solubility of oleic and linoleic acids in subcritical water Reviewed
P Khuwijitjaru, Y Kimura, R Matsuno, S Adachi
FOOD SCIENCE AND TECHNOLOGY RESEARCH 10 ( 3 ) 261 - 263 2004.8
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Kinetics on the hydrolysis of fatty acid esters in subcritical water Reviewed
P Khuwijitjaru, T Fujii, S Adachi, Y Kimura, R Matsuno
CHEMICAL ENGINEERING JOURNAL 99 ( 1 ) 1 - 4 2004.5
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Effect of the hydrophilic surfactants on the preparation and encapsulation efficiency in course and fine W/O/W type emulsions
M Shima, Y Kobayashi, Y Kimura, S Adachi, R Matsuno
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 238 ( 1-3 ) 83 - 90 2004.5
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Hydrolysis of disaccharides containing glucose residue in subcritical water Reviewed
T Oomori, SH Khajavi, Y Kimura, S Adachi, R Matsuno
BIOCHEMICAL ENGINEERING JOURNAL 18 ( 2 ) 143 - 147 2004.5
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Relationship between structure and permeability of dipeptide derivatives containing tryptophan and related compounds across human intestinal epithelial (Caco-2) cells Reviewed
R Ano, Y Kimura, M Urakami, M Shima, R Matsuno, T Ueno, M Akamatsu
BIOORGANIC & MEDICINAL CHEMISTRY 12 ( 1 ) 249 - 255 2004.1
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Preparation of fine W/O/W emulsion through membrane filtration of coarse W/O/W emulsion and disappearance of the inclusion of outer phase solution Reviewed
M Shima, Y Kobayashi, T Fujii, M Tanaka, Y Kimura, S Adachi, R Matsuno
FOOD HYDROCOLLOIDS 18 ( 1 ) 61 - 70 2004.1
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Decomposition kinetics of maltose in subcritical water Reviewed
SH Khajavi, Y Kimura, T Oomori, R Matsuno, S Adachi
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 68 ( 1 ) 91 - 95 2004.1
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Hydrolysis of the oil phase of a W/O/W emulsion by pancreatic lipase Reviewed
M Shima, M Tanaka, Y Kimura, S Adachi, R Matsuno
JOURNAL OF CONTROLLED RELEASE 94 ( 1 ) 53 - 61 2004.1
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Relationships between structure and high-throughput screening permeability of peptide derivatives and related compounds with artificial membranes: application to prediction of Caco-2 cell permeability Reviewed
R Ano, Y Kimura, M Shima, R Matsuno, T Ueno, M Akamatsu
BIOORGANIC & MEDICINAL CHEMISTRY 12 ( 1 ) 257 - 264 2004.1
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Kinetics on Disaccharide Decomposition in Subcritical Water
Kimura Yukitaka, Khajavi Shabnam Haghighat, Oomori Toshinobu, Matsuno Ryuichi, Adachi Shuji
Asian Pacific Confederation of Chemical Engineering congress program and abstracts 2004 374 - 374 2004
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Anti-oxidant activity of acyl ascorbates in intestinal epithelial cells Reviewed
Y Kimura, H Kanatani, M Shima, S Adachi, R Matsuno
BIOTECHNOLOGY LETTERS 25 ( 20 ) 1723 - 1727 2003.10
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Relationship between structure and permeability of tryptophan derivatives across human intestinal epithelial (Caco-2) cells Reviewed
M Urakami, R Ano, Y Kimura, M Shima, R Matsuno, T Ueno, M Akamatsu
ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES 58 ( 1-2 ) 135 - 142 2003.1
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Effects of medium-chain fatty acids on intracellular calcium levels and the cytoskeleton in human intestinal (Caco-2) cell monolayers Reviewed
Y Kimura, Y Hosoda, M Yamaguchi, H Nagano, M Shima, S Adachi, R Matsuno
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 65 ( 4 ) 743 - 751 2001.4
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Recovery of Caco-2 cell monolayers to normal from the transport-enhanced state induced by capric acid sodium salt an its monoacylglycerol Reviewed
M Shima, Y Kimura, S Adachi, R Matsuno
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 63 ( 4 ) 680 - 687 1999.4
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Physico-chemical properties of fatty acids for assessing the threshold concentration to enhance the absorption of a hydrophilic substance Reviewed
Y Kimura, Y Hosoda, M Shima, S Adachi, R Matsuno
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 62 ( 3 ) 443 - 447 1998.3
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Absorption enhancement through intracellular regulation of tight junction permeability by medium chain fatty acids in Caco-2 cells Reviewed
T Lindmark, Y Kimura, P Artursson
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 284 ( 1 ) 362 - 369 1998.1
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The relationship between transport-enhancement effects and cell viability by capric acid sodium salt, monocaprin, and dicaproin Reviewed
M Shima, Y Kimura, S Adachi, R Matsuno
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 62 ( 1 ) 83 - 86 1998.1
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Effects of medium-chain fatty acids and their acylglycerols on the transport of penicillin V across Caco-2 cell monolayers Reviewed
M Shima, K Yohdoh, M Yamaguchi, Y Kimura, S Adachi, R Matsuno
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 61 ( 7 ) 1150 - 1155 1997.7
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EFFECTS OF A PEPTIDE MIXTURE WITH A HIGH FISCHERS RATIO ON SERUM AND CEREBRAL-CORTEX AMINO-ACID LEVELS AND ON CEREBRAL-CORTEX MONOAMINE LEVELS, COMPARED WITH AN AMINO-ACID MIXTURE WITH A HIGH FISCHERS RATIO Reviewed
CH ODAGIMA, Y KIMURA, S ADACHI, R MATSUNO, H YOKOGOSHI
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 59 ( 4 ) 731 - 734 1995.4
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EQUILIBRIUM YIELD OF N-ALKYL-BETA-D-GLUCOSIDE THROUGH CONDENSATION OF GLUCOSE AND N-ALCOHOL BY BETA-GLUCOSIDASE IN A BIPHASIC SYSTEM Reviewed
C PANINTRARUX, S ADACHI, Y ARAKI, Y KIMURA, R MATSUNO
ENZYME AND MICROBIAL TECHNOLOGY 17 ( 1 ) 32 - 40 1995.1
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Trypsin-catalyzed synthesis of oligopeptides containing hydrophilic and essential amino acid, L-lysine. Reviewed
Y Kimura, M Shima, T Notsu, S Adachi, R Matsuno
DEVELOPMENTS IN FOOD ENGINEERING, PTS 1 AND 2 582 - 584 1994
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Separation of Alkyl β-D-Glucosides and n-Alcohols by Using a Porous Tnmethylolpropane Trimethacrylate Homopolymer Gel Reviewed
Shuji Adachi, Chaiya Panintrarux, Yoichi Araki, Yukitaka Kimura, Ryuichi Matsuno
Bioscience, Biotechnology, and Biochemistry 58 ( 9 ) 1558 - 1563 1994
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Preperation of peptide mixture with High Fischer ratio from protein hydrolysate by adsorption on activated carbon Reviewed
Bioseparation 3 227 - 232 1993
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FACTORS AFFECTING PERFORMANCE OF A PROTEINASE-CATALYZED BIOREACTOR FOR OLIGOPEPTIDE SYNTHESES Reviewed
R MATSUNO, Y KIMURA, S ADACHI, K NAKANISHI
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 672 363 - 373 1992.11
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FACTORS AFFECTING PERFORMANCE OF A PROTEINASE-CATALYZED BIOREACTOR FOR OLIGOPEPTIDE SYNTHESES Reviewed
R MATSUNO, Y KIMURA, S ADACHI, K NAKANISHI
ENZYME ENGINEERING XI 672 363 - 373 1992
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ENZYMATIC-SYNTHESIS OF PEPTIDES WITH HYDROPHILIC AMINO-ACID IN WATER-MISCIBLE ORGANIC-SOLVENT Reviewed
Y KIMURA, Y TARI, S ADACHI, R MATSUNO
ENZYME ENGINEERING XI 672 458 - 461 1992
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SEPARATION OF PEPTIDE GROUPS WITH DEFINITE CHARACTERISTICS FROM ENZYMATIC PROTEIN HYDROLYSATE Reviewed
S ADACHI, Y KIMURA, K MURAKAMI, R MATSUNO, H YOKOGOSHI
AGRICULTURAL AND BIOLOGICAL CHEMISTRY 55 ( 4 ) 925 - 932 1991.4
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SYNTHESIS OF PEPTIDES CONSISTING OF ESSENTIAL AMINO-ACIDS BY A REACTOR SYSTEM USING 3 PROTEINASES AND AN ORGANIC-SOLVENT Reviewed
Y KIMURA, K MURAYA, Y ARAKI, H MATSUOKA, K NAKANISHI, R MATSUNO
AGRICULTURAL AND BIOLOGICAL CHEMISTRY 54 ( 12 ) 3331 - 3333 1990.12
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CONTINUOUS SYNTHESIS OF A TRIPEPTIDE BY SUCCESSIVE CONDENSATION AND TRANSESTERIFICATION CATALYZED BY 2 IMMOBILIZED PROTEINASES IN ORGANIC-SOLVENT Reviewed
Y KIMURA, T YOSHIDA, K MURAYA, K NAKANISHI, R MATSUNO
AGRICULTURAL AND BIOLOGICAL CHEMISTRY 54 ( 6 ) 1433 - 1440 1990.6
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ENZYMATIC-SYNTHESIS OF THE PRECURSOR OF LEU-ENKEPHALIN IN WATER-IMMISCIBLE ORGANIC-SOLVENT SYSTEMS Reviewed
Y KIMURA, K NAKANISHI, R MATSUNO
ENZYME AND MICROBIAL TECHNOLOGY 12 ( 4 ) 272 - 280 1990.4
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KINETICS AND EQUILIBRIUM OF ENZYMATIC-SYNTHESIS OF PEPTIDES IN AQUEOUS ORGANIC BIPHASIC SYSTEMS - THERMOLYSIN-CATALYZED SYNTHESIS OF N-(BENZYLOXYCARBONYL)-L-ASPARTYL-L-PHENYLALANINE METHYL-ESTER Reviewed
K NAKANISHI, Y KIMURA, R MATSUNO
EUROPEAN JOURNAL OF BIOCHEMISTRY 161 ( 3 ) 541 - 549 1986.12
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Design of proteinase-cataiyzed synthesis of oligopeptides in an aqueous-organic biphasic system Reviewed
Kazuhiro Nakanishi, Yukitaka Kimura, Ryuichi Matsuno
Bio/Technology 4 ( 5 ) 452 - 454 1986
MISC
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島内 寿徳, 木村 幸敬, 藤岡 沙都子, 寺坂 宏一
化学工学 = Chemical engineering of Japan 87 ( 1 ) 22 - 25 2023.1
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Production of a Monomer of a Biomass Plastic from Woody Biomass~Three Chemical Processes Using Water as Key Technology~ Invited
木村幸敬, 島内寿徳
水環境学会誌 44(A) ( 7 ) 2021
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Role of Dynamic Space in Lipid Membranes for the Reaction Field
福間早紀, 島内寿徳, 木村幸敬
膜 45 ( 3 ) 2020
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水素発生を目指したリポソーム/単層カーボンナノチューブ/フラロデンドロン光触媒複合材料の評価
寺井公亮, 島内寿徳, 内藤雅晴, 袴塚響, 田嶋智之, 高口豊, 木村幸敬
化学工学会年会研究発表講演要旨集(CD-ROM) 85th 2020
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Analysis of Microscopic Dynamics of Membrane Interfaces Based on Dielectric Measurement
島内寿徳, 福間早紀, 木村幸敬
表面と真空 62 ( 4 ) 2019
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亜臨界水による木質バイオマスの分解とバイオプラスチックモノマーの生産 Invited
木村幸敬
農薬環境科学研究 ( 27 ) 2019
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Molecular Recognition/Transformation Based on Membrane Dynamics
41 ( 5 ) 244 - 250 2016.9
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Microfluidicsを利用したヒドロゲルカプセル新規調製法の開発
安川政宏, 小野努, 木村幸敬
化学とマイクロ・ナノシステム研究会講演要旨集 25th 2012
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水相をコアテンプレートとした新規ヒドロゲルカプセル調製法の開発
安川政宏, 小野努, 木村幸敬
高分子ゲル研究討論会講演要旨集 22nd 2011
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ハイドロゲル内包マイクロカプセルの膜形成機構に及ぼす因子の検討
谷昌彦, 安川政宏, 小野努, 木村幸敬
化学工学会秋季大会研究発表講演要旨集(CD-ROM) 43rd 2011
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ハイドロゲル粒子を芯物質とした鈴型構造を有する粒子の調製
谷昌彦, 安川政宏, 小野努, 木村幸敬
高分子学会予稿集(CD-ROM) 60 ( 2 Disk1 ) 2011
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マイクロ流体デバイスと液・液相分離を利用した単分散ゲルカプセル調製
安川政宏, 小野努, 木村幸敬
高分子学会予稿集(CD-ROM) 59 ( 2 Disk1 ) 2010
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マイクロ流体デバイスと光重合を利用した単分散ゲル粒子調製に関する検討
安川 政宏, 小野 努, 木村 幸敬
化学工学会 研究発表講演要旨集 2010 ( 0 ) 475 - 475 2010
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マイクロ流路を利用した単分散複合エマルション調製における制御因子の検討
伊東 一行, 安川 政宏, 小野 努, 木村 幸敬
化学工学会 研究発表講演要旨集 2010 ( 0 ) 383 - 383 2010
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2Lp11 Development of high-throughput screening by culture in monodisperse gel particles
WASHIO Naoki, ONO Tsutomu, KIMURA Yukitaka
21 175 - 175 2009
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水性二相系を利用したW/W/Oエマルションの調製とゲルカプセルへの応用
安川政宏, 小野努, 木村幸敬
ポリマー材料フォーラム講演予稿集 18th 2009
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Continuous Synthesis of Glyceryl Ferulate Using Immobilized Candida antarctica Lipase Reviewed
Takemasa Matsuo, Takashi Kobayashi, Yukitaka Kimura, Asao Hosoda, Hisaji Taniguchi, Shuji Adachi
JOURNAL OF OLEO SCIENCE 57 ( 7 ) 375 - 380 2008.7
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Effect of salt on the decomposition of saccharides in subcritical water
2006 147 - 153 2006
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腸管吸収を促進する可食性エマルジョン Invited
バイオサイエンスとインダストリー 60 679 - 682 2002
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Caco-2培養細胞単一層膜を用いた中鎖脂肪酸化合物によるペニシリンV透過促進と細胞生存率への影響の評価 : 食品 Invited
島 元啓, 木村 幸敬, 安達 修二, 松野 隆一
日本農藝化學會誌 70 14 - 14 1996.3
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Regulation of immediate and long term effects of the absorption enhancer sodium caprate in human intestinal epithelial (Caco-2) cells.
Y Kimura, T Lindmark, P Artursson
23RD INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, 1996 PROCEEDINGS 23 423 - 424 1996
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中鎖脂肪酸の有する腸管吸収促進機構の解明 Invited
BRAINテクノニュース 58 30 - 32 1996
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培養細胞を用いた腸管吸収促進剤の評価 Invited
酵素工学ニュース 36 11 - 14 1996
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北欧最古の大学都市スウェーデン ウプサラ -ウプサラ大学薬学部バイオメディカルセンターに留学して- Invited
木村 幸敬
化学と生物 34 ( 7 ) 440 - 443 1996
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緩衝液飽和オクタノール中でのβ-グルコシダーゼによるオクチルグルコシドの合成 : 生物化学工学 Invited
Panintrarux Chaiya, 木村 幸敬, 安達 修二, 松野 隆一
日本農藝化學會誌 69 283 - 283 1995.7
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Caco-2培養細胞単一層膜を用いた中鎖脂肪酸およびそのグリセリドの有する生理活性物質吸収促進能の評価 : 食品 Invited
島 元啓, 踊堂 かおり, 山口 雅世, 木村 幸敬, 安達 修二, 松野 隆一
日本農藝化學會誌 69 363 - 363 1995.7
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Equilibrium study of alkyl-β-D-glucoside synthesis from glucose and alcohol by β-glucosidase Reviewed
Y. Kimura, C. Panintrarux, S. Adachi, R. Matsuno
Annals of the New York Academy of Sciences 750 312 - 316 1995
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ENZYMATIC-SYNTHESIS OF PEPTIDES WITH HYDROPHILIC AMINO-ACID IN WATER-MISCIBLE ORGANIC-SOLVENT
Y KIMURA, Y TARI, S ADACHI, R MATSUNO
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 672 458 - 461 1992.11
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Proteinase-Catalyzed Synthesis of Peptide in Organic Solvent
Yukitaka Kimura, Ryuichi Matsuno
Nippon Nogeikagaku Kaishi 65 ( 7 ) 1111 - 1114 1991
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The separation of a characteristic peptide group from protein hydrolyzate. Invited
安達修二, 木村幸敬, 村上浩二, 松野隆一, 横越英彦
化学工学シンポジウムシリーズ 27 1991
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Continuous Peptide Syntheses with Immobilized Enzymes in Organic Solvent
Nakanishi Kazuhiro, Tanaka Takaaki, Kimura Yukitaka, Matsuno Ryuichi
2 39 - 39 1990
Awards
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井上奨励賞
1992
Research Projects
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Systematization of Reaction Extraction Process Oriented to Implementation of Production of Materials of PLA from Waste Glycerin
Grant number：23K11490 2023.04 - 2026.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
木村 幸敬
Grant amount：\4680000 （ Direct expense: \3600000 、 Indirect expense：\1080000 ）
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Grant number：23658275 2011 - 2012
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research Grant-in-Aid for Challenging Exploratory Research
KIMURA Yukitaka
Grant amount：\3900000 （ Direct expense: \3000000 、 Indirect expense：\900000 ）
The final objective of this study is to expand the utilization of cellulose, which is one of the main compounds ascarbon resource in the earth. For that, I tried to synthesize a linier block co-polymer with cellulose and a hydrophobic/hydrophilic polymer. The co-polymer is expected to dissolve in water or oil and to exhibit molecular orientation although cellulose itself is not. This study established the preparations for glucose whose hydroxyl groups except the first position were protected and for glucose with methoxy polyethylene glycol at the first position.
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Grant number：19580136 2007 - 2008
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)
KIMURA Yukitaka
Grant amount：\4680000 （ Direct expense: \3600000 、 Indirect expense：\1080000 ）
100℃以上で臨界点(374℃)以下の温度領域で, 液体状態が保たれた亜臨界水は常温常圧の水に比べて, 比誘電率が低く, またイオン積が500~1000倍程度大きい。これらの性質によって, 亜臨界水は疎水性物質の抽出への利用や酸または塩基触媒としての利用が可能である。本研究では, 亜臨界水中での食品成分の分解速度がpH変化および電気伝導度に影響する塩に影響を受ける現象に関して, 亜臨界水中での五単糖, ウロン酸, アミノ酸分解を試み, そのpHと分解動力学について反応機構を検討した。また, 糖の加水分解について, 塩が分解速度に影響することを見出した。
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Non-catalytic synthesis of food components in subcritical water
Grant number：16580098 2004 - 2006
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)
KIMURA Yukitaka, SHIMA Motohiro
Grant amount：\3700000 （ Direct expense: \3700000 ）
Water which is maintained in its liquid state at 100-374℃ and a high pressure is called as subcritical water. In subcritical water, the ion product of H^+ and OH^-increases about a thousand times higher than that in an ambient water. It makes non-catalytic reaction proceed in subcritical water. The non-catalytic reaction is good for environment in the earth and is available to construct a good food processing system. So, I investigated non-catalytic reaction to synthesize food components in subcritical water. Firstly, converted reaction from monosaccharides to 5-hydroxy-2-methyl furfural (HMF) was studied during hydrolysis of monosaccharides in subcritical water. The kinetics of hydrolysis of four kinds of monosaccharides obeys to Weibull equation. Fructose gave the highest conversion, 48%, of HMF among fructose, galactose, glucose, and mannose. Secondly, we confirmed that condensation reaction between a peptide and a dicarboxylic acid proceeded without any catalytic agent additive in subcritical water (100-140℃) by analysis of the product via LC-MS and MALDI-TOF. The higher temperature and the lesser number of OH residue in the dicarboxylic acids gave a higher yield of the condensation product. Finally, isomerization from linoleic acid to its conjugated isomers in subcritical water (200-260℃) was investigated. Elongation of reaction time and higher temperature gave a higher yield of the conjugated linoleic acids (CLA). However, the conversion was very low, 1%, even in the maximum value. The ratio of trans-10, cis-12 CLA to cis-9, trans-11 CLA was constantly 0.6 in any conditions of the reactions. As mentioned above, it became clear that hydrolysis, synthesis, and isomerization proceed without any catalytic reagent additive in subcritical water and that food components can be produced through these reactions.
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亜臨界条件下における水・有機溶媒混合液を用いた食品素材物質の合成の可能性
Grant number：15658043 2003 - 2004
日本学術振興会 科学研究費助成事業 萌芽研究 萌芽研究
安達 修二, 木村 幸敬
Grant amount：\3800000 （ Direct expense: \3800000 ）
常温の水に比べてイオン積が大きく,水自体が酸または塩基触媒として作用すると期待される亜臨界水を用いた食品素材物質の合成の可能性を,オクタペプチドであるアンジオテンシンIIとジカルボン酸,および糖アルコールであるエリスリトールとオクタン酸の縮合反応について検討した.前年度に,100℃〜130℃という比較的低温の亜臨界水中で前者の反応が進行することを見出していた.そこで本年度はまず,有機溶媒の添加効果について検討したところ,理由は不明であるが,水濃度の低下は縮合生成物の収率に顕著な影響を及ぼさなかった.次に,アンジオテンシンIIの各種類縁ペプチドおよび水酸基数の異なる各種ジカルボン酸の亜臨界水中での反応性の差異について検討したところ,ほとんどの組み合わせで対応する縮合物が生成することをLC-MSを用いて確認した.検討した炭素数4のジカルボン酸では水酸基の数が少ないほど,アンジオテンシンIIとの縮合物の収率が高かった.また,アンジオテンシンII類縁ペプチドの大半はジカルボン酸と反応して対応する縮合物を与えた.また,アミノ酸でも縮合物を生成する場合があり,これらの反応にアルギニンまたはアスパラギン酸残基が関与する可能性が示されたが,確証を得るには至っていない.また,水の濃度を極限的に低下した系に相当する無溶媒系(185℃)でエリスリトールとオクタン酸の縮合の可否について検討したところ,HPLC分析において溶出時間の異なる2または3種のエステルと思われる生成物が認められた,生成物の同定には至っていないが,無溶媒・無触媒系で食品素材物質が合成できる可能性が示唆された.
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亜臨界水を用いた食品加工に関する研究
2002
Grant type：Competitive
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Study on Food Enjineering using Subcritical Water
2002
Grant type：Competitive
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Design of the in vitro model with a cultured intestinal cell monolayer and pseudo lymph and blood streams for assessment of the absorption of a hydrophobic substance
Grant number：12460057 2000 - 2002
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B) Grant-in-Aid for Scientific Research (B)
MATSUNO Ryuichi, SHIMA Moohiro, KIMURA Yukitaka
Grant amount：\15500000 （ Direct expense: \15500000 ）
The hydrophobic substance is absorbed from the intestinal tract into the blood or lymph in vivo. This project intended to design the simple in vitro model which can be compared with the absorption process in vivo and independently control the blood stream and the lymph stream making use of the cultured cell layer which differentiates.
Most part of this research was analysis of absorption of the hydrophobic substance to the cells and through the cell layer. It was found that the hydrophobic substances accumulated into the cell layer and that there was a possibility to improve the absorption of a hydrophobic substance, which is easily decomposed by digestive enzymes and possesses an electric charge, by adding another hydrophobic substance which possesses the counter electric charge because the electrostatic interaction between both substances prevented enzymatic hydrolysis of the substance and accelerated the absorption rate. And the absorption of acyl ascorbates, which possess an anti-oxidation property, to the cell layer was also analyzed in detail including the non-enzymatically hydrolytic process. Furthermore, it was found that the acyl ascorbates granted a strong anti-oxidation property against the oxidant from the lumen side to the intestinal tract absorption cell, Caco-2.
The various conditions necessary for model construction were examined. Tricaprylin was one of the good compounds as a pseudo lymph component. A membrane filter was selected for the easy transmit of a hydrophobic substance from the hydrophilic solution (suitable to the blood) to the hydrophobic solution (suitable to the lymph). In addition, it was verified that the influx outflow of the solution to the compartment of blood side can be controlled with an infusion pump and was decided the churning condition for complete mixing of the small compartment. These findings would enable the construction of the in vitro model for assessment of the absorption of a hydrophobic substance. -
難吸収生理活性物質の腸管吸収速度を制御するための培養細胞を用いたモデリング
Grant number：10750575 1998 - 1999
日本学術振興会 科学研究費助成事業 奨励研究(A) 奨励研究(A)
木村 幸敬
Grant amount：\2100000 （ Direct expense: \2100000 ）
本年度は以下の項目について研究を実施した。
1)吸収促進能の発現と中鎖脂肪酸の蓄積・透過過程の解析
プラスティックウェル上に生育させたCaco-2細胞層への侵入蓄積過程をラジオアイソトープラベルしたオクタン酸(C8)、デカン酸(C10)、ドデカン酸(C12)を用いて実験し、解析した。細胞層への浸入係数は、pH7.3でそれぞれ3.4×10^<-5>(C8)、3.4×10^<-5>(C10)、1.6×10^<-4>(C12)(cm/s)であり、疎水度の高いC12が最も速く浸入した。溶液のpHを変化させてもこれらの係数はほとんど変化しなかった。また、細胞層への分配係数も4.4×10^2(C8)、5.9×10^2(C10)、2.9×10^3(C12)という値が得られ、中鎖脂肪酸が示す吸収促進能発現機構のシミュレートモデルの基礎因子を解明した。
2)腸溶性カプセルの作製と試験
親水性難吸収性物質の吸収促進に必要な濃度という因子や良好なカプセル化という因子などを考察し、中鎖脂肪酸を封入した腸溶性ゼラチンカプセルを調製した。
3)実用化の安全性試験
奇数鎖の脂肪酸を含むC8〜C12をCaco-2細胞層に一定時間さらした後に、細胞ミトコンドリアデヒドロゲナーゼ活性をMTT法で、細胞骨格への影響をアクチンフィラメント染色で測定した。親水性物質透過の促進効果が同程度であるとき、MTT活性を最も下げたのがC10であり、C12はMTT活性を保持させることが明らかになった。C10のみがアクチンフィラメントを大きく変化させることが明らかになった。これらの手法の、細胞安全性試験の第1次スクリーニングとしての可能性を示した。 -
Enzymatic acylation of vitamin C with medium-chain fatty acids and estimation of intestinal absorbability of the products
Grant number：09650874 1997 - 1998
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)
ADACHI Shuji, KIMURA Yukitaka
Grant amount：\3300000 （ Direct expense: \3300000 ）
The absorbability of vitamin C (ascorbic acid) in the intestine is low because of its hydrophilicity. It has been known that medium-chain fatty acids enhance the intestinal absorption of hydrophilic substances. In this context, this projects intended to improve the absorbability of vitamin C by its enzymatic acylation with medium-chain fatty acid. The products are also expected to be oil-soluble reducing agent and surfactant with reducing ability. It was found that immobilized lipase from Candida antarctic could catalyze the condensation of ascorbic acid and lauric acid in acetonitrile, and that the equilibrium yield of the condensation became higher at the lower water content of the solvent. The chain length of acyl residue of fatty acids scarcely affected the equilibrium yield of the products. Because acetonitrile would not be adequate for application to food, some water-miscible organic solvents were tested for the reaction medium of the condensation to find more adequate solvent. Acetone, which could be easily removed in the purification step of the products due to its high volatility, was also a good solvent for the condensation, and the equilibrium yield was higher at the lower water content in the solvent. The mechanism on the absorption of hydrophilic substances at the intestine was examined by using the cultured Caco-2 cell. Surfactant property of medium-chain fatty acids was concerned in the adsorption enhancement. Ascorbic acid acylated with medium-chain fatty acid was fairly strongly surface active. Thus, the method for enzymatic acylation of ascorbic acid has been established, and the basic knowledge on the improvement of absorption of ascorbic acid in the intestine has been obtained.
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中鎖脂肪酸グリセリド分解物の有する腸管からの吸収促進機構の解明
Grant number：08760133 1996
日本学術振興会 科学研究費助成事業 奨励研究(A) 奨励研究(A)
木村 幸敬
Grant amount：\1000000 （ Direct expense: \1000000 ）
1.中鎖脂肪酸グリセリド分解物が与える腸管吸収促進の経路の特定
メンブレンフィルター上に培養したヒト結腸癌由来のCaco-2を用いて、中鎖脂肪酸グリセリド分解物が与える腸管吸収促進の経路について以下の結果を得た。腸管側に促進物質を加えると、細胞間隙を通過する経路のマーカーとして用いた親水性薬物・ペニシリンVの透過が促進された。また細胞間隙経路の指標である細胞層を隔てた電気抵抗が低下し、促進される経路が細胞間隙であることが示された。さらに、透過経路のモデルをたて、細胞のミトコンンドリアでのデヒドロゲナーゼ活性を指標とした実験(MTT法)で得られた細胞の障害率とその時の透過係数の値から、細胞間隙を透過するモデルが障害率と透過係数の関係をよく説明することを明らかにした。なお、このモデルを96年9月の化学工学会シンポジウムにおいて発表した(Shima M.et a1.)。
2.細胞内シグナル伝達系阻害剤を用いたC10脂肪酸の作用機構の解明
細胞内情報伝達経賂の内phospholipase Cを介する経路の様々な段階での阻害剤を用いてC10脂肪酸の作用機構への細胞情報伝達系の関与について研究をした。diacylglycerolのアナログがC10の促進効果を阻害し、inositol trisphosphateが関与する経路の阻害剤のいくつかがC10の促進効果を阻害した。C10はこれらの経路に相反する様式で影響して、吸収促進効果を与えることが示唆された。これらの結果は、97年1月の日本薬学会関東支部シンポジウムで発表し、Proc.Int.Symp.Control.Release Bioact.Mater.にも発表した. -
Solvent Engineering on Enzymatic Synthesis of Edible Surfactants
Grant number：06453175 1994 - 1996
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B) Grant-in-Aid for Scientific Research (B)
MATSUNO Ryuichi, KIMURA Yukitaka, ADACHI Shuji
Grant amount：\7300000 （ Direct expense: \7300000 ）
Enzymatic synthesis of edible surfactants from hydrophilic and hydrophobic ingredients in food was invesigated. In the first stage of this investigation, b-glucosidase-catalyzed synthesis of alkyl glucosides was made to understand phenomena occuring in such synthetic reaction, although the glucosides are not edible but have a wide range of industrial use. We proposed the equations to predict the yields of desired product and by-products in a conventional aqueous-organic biphasic system, where one of substrates, alcohol, itself was an organic phase. It was found that the equilibrium constant for condensation of glucose and alcohol was independent of the alkyl chain length of alcohol. We proposed a novel reaction system where solid enzyme and glucose were added to alcohol saturated with a buffer. The equilibrium yield of alkyl glucoside in the proposed system was much higher than that in the conventional two-phase system. High stability of the enzyme in the system allowed its reuse in subsequent condensation. It was also found in the system that both of (R) -and (S) -isomers of secondary alcohol could be condensed with glucose by the enzyme to give corresponding glucosides in high yield. A packing material for effective liquid-chromatographic separation of alkyl glucoside and alcohol was found out. A model was proposed to explain the dependence of elution times of solutes on the composition of eluent. Simple methods were proposed for estimation of adsorption isotherm of a solute on an adesorbent from only a pulse response curve ofthe solute. Acylation of erythritol and ascorbic acid by immobilized lipase was also examined. The acylation proceeded stereoselectively in acetonitril with extremely low content of water. The products were identified to be desired products by NMR analysis.
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中鎖脂肪酸トリグリセリドを利用した生理活性物質吸収促進機能を有する食品の構築
Grant number：06856019 1994
日本学術振興会 科学研究費助成事業 奨励研究(A) 奨励研究(A)
木村 幸敬
Grant amount：\800000 （ Direct expense: \800000 ）
1.培養細胞系の確立
小腸上皮吸収細胞様の機能を発現するヒト結腸ガン細胞Caco-2を使用した培養系の確立を目指した。tight junctionの形成度の指標として細胞層を隔てた電気抵抗を測定した。培養2日目以降に高い抵抗値が得られた。電子顕微鏡による観察で、17-19日程度培養した細胞では、micro villiも観察され、吸収実験を行うのに最適である培養系(培養後17-19日)が確立された。
2.促進能とトリグリセリドの分解度との相関関係の解析
トリグリセリドやその分解物である各成分について、吸収促進能を上記培養細胞系で測定した。すなわち、炭素鎖長6,8,10の脂肪酸(FA)やそれからなるモノ・ジ・トリグリセリド(MG,DG,TG)存在下(10mM)での生理活性モデル物質ペニシリンVの細胞層透過速度を測定した。測定には、拡散チャンバーを用いた。各成分のうちC6-DG,C8-MG,C10-MG,C10FA存在下の透過速度がそれぞれコントロールの197倍、220倍、190倍、13倍であった。その他の成分はコントロールと差が見られなかった。これらの促進能がそれぞれの成分の界面活性と正の相関があることを明らかにした。これらの成分を混合して使用した際の促進能力については、現在検討中である。
本年度で得られた知見を、1995年度の農芸化学会本大会で発表する予定である。また、近く論文として投稿する。 -
アミノアシラーゼによる脂肪酸とアミノ酸からの天然界面活性剤の合成に関する研究
Grant number：03856032 1991
日本学術振興会 科学研究費助成事業 奨励研究(A) 奨励研究(A)
木村 幸敬
Grant amount：\800000 （ Direct expense: \800000 ）
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Enzymatic synthesis of physiologically functional oligopeptides consisting of essential amino acids
Grant number：02453131 1990 - 1992
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for General Scientific Research (B) Grant-in-Aid for General Scientific Research (B)
MATSUNO Ryuichi, NAKANISHI Kazuhiro, KIMURA Yukitaka, ADACHI Shuji
Grant amount：\7700000 （ Direct expense: \7700000 ）
Oligopeptides possess some physiologically superior functionalities such as higher assimilation rate at the brush boader membrane of the intestine, compared with their constituent amino acids. In this study,enzymatic syntheses of oligopeptides including of essential amino acids have been successfully realized. Thermolysin (TL), alpha-chymotrypsin (CT), and papain (PP) were used in organic solvent or in organic/aqueous biphasic system to synthesize di- and tripeptides by their condensation or transfer action. An example of tripeptide synthesized is Z-GFLNH_2. The tripeptide was continuously synthesized by using two columns packed with immobilized TL and CT, which were connected in series, at an yield of more than 80% for 220 h. The oligopeptides synthesized, which included essential amino acids and histidine, were as follows: Z-K(Z)IOMe (TL;condensation, ca. 100%), Z-TWOEt (PP; transfer, 73%), Z-TWVNH_2 (CT; condensation, ca. 100%), Z-LFOMe (TL; condensation, ca. 100%), Z-MLFOMe (TL; condensation, ca. 100%), Boc-H(Tos)VOEt (PP; condensation, 91%). The water content in the reaction system, in some cases, significantly affected the mass transfer rates of substrates into immobilized enzymes. An increase of the content resulted in a large mass transfer resistance. We proposed a novel enzymatic method to synthesize the precursor of an opioid peptide, Leu-enkephalin, Z-YGGFLOEt from its constituent amino acid derivatives by using CT, TL, and PP. The validity of the method was demonstrated experimentally. Some peptides including a basic essential amino acid, K were synthesized by trypsin in a mixture of acetonitrile and buffer solution. Examinations were focused on the synthesis of di- or tripeptides consisting of only K. We found the conditions where a high yield of objective could be realized and maintained for a long period. This study showed that a variety of oligopeptides could be synthesized in high yields using only four proteinases, and constructed the system to produce many kinds of products in a relatively small amount, which is directed in bioprocess development.
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プロテアーゼによるペプチド合成反応に関する研究
Grant number：01790456 1989
日本学術振興会 科学研究費助成事業 奨励研究(A) 奨励研究(A)
木村 幸敬
Grant amount：\1000000 （ Direct expense: \1000000 ）
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加水分解酵素を用いた有用物質合成に関する研究
1984
Grant type：Competitive
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Study on synthesis of availably biochemical materials by hydrolytic enzyme
1984
Grant type：Competitive
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小腸上皮吸収細胞における機能性食品の吸収過程の解析
Grant type：Competitive
-
Study on absorption of physiologically functional foods through absorbtive cells in intestine.
Grant type：Competitive
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Heat and Mass Balances （2023academic year） 1st semester - 月7～8
-
SDGs:Energy and Entropy （2023academic year） Third semester - 月7～8
-
Advanced Course of Innovation （2023academic year） Prophase - その他
-
Advanced Course of Innovation （2023academic year） Prophase - その他
-
Energy and Entropy （2023academic year） Third semester - 月7～8
-
Design of Chemical Process Ⅱ （2023academic year） Summer concentration - その他
-
Design of Chemical Process I （2023academic year） Third semester - 木5～8
-
Functional Ceramics Chemistry （2023academic year） Second semester - 火3～4,金1～2
-
Low-carbon and Resource Circulation Process Engineering （2023academic year） Prophase - 月3～4
-
Chemical Process Engineering （2023academic year） Third semester - 金3～4
-
Chemical Process Engineering Ⅱ （2023academic year） Second semester - その他
-
Chemical Process Engineering I （2023academic year） Summer concentration - その他
-
Basic of Applied Chemistry and Biotechnology （2023academic year） 1st semester - 金1～2
-
Introduction to Applied Chemistry and Biotechnology Program （2023academic year） Third semester - 水1～2
-
Introduction to Applied Chemistry and Biotechnology Program （2023academic year） Third semester - 水1～2
-
Introduction to Applied Chemistry and Biotechnology Program （2023academic year） Third semester - 水1～2
-
Introduction to Applied Chemistry and Biotechnology Program （2023academic year） Third semester - 水1～2
-
Safety for Chemistry Experiments （2023academic year） 1st semester - 火1～2
-
Lecture and Exercises for Safety in Chemical Experiments （2023academic year） 1st semester - 火1～2
-
Chemical Engineering 3 （2023academic year） Third semester - 金3～4
-
Chemical Engineering 4 （2023academic year） Fourth semester - 金1～2
-
Chemical Engineering I （2023academic year） Fourth semester - 水1～2
-
Chemical Reaction Engineering Ⅱ （2023academic year） Fourth semester - 金1～2
-
Chemical Reaction Engineering I （2023academic year） 1st semester - 火4,金2
-
Chemical Reactions and Its Dynamics （2023academic year） Third semester - 火1～2
-
Fundamental of Chemical Engineering （2023academic year） Second semester - その他
-
Fundamentals of Organic Chemistry （2023academic year） 1st semester - 金3～4
-
Fundamental Inorganic Chemistry （2023academic year） Second semester - 月2,木4
-
Exercise in Basic English （2023academic year） 1st semester - その他
-
Exercise in Basic English （2023academic year） Second semester - その他
-
Exercise in Basic English （2023academic year） Second semester - その他
-
Exercise in Basic English （2023academic year） 1st semester - その他
-
Exercise for Reading English Articles A （2023academic year） 1st semester - 水3～4
-
Exercise for Reading English Articles B （2023academic year） Second semester - 水3～4
-
Differential Equation （2023academic year） 3rd and 4th semester - 火3～4
-
Differential Equation （2023academic year） 3rd and 4th semester - 火3～4
-
Differential Equation 1 （2023academic year） Third semester - 火3～4
-
Differential Equation 2 （2023academic year） Fourth semester - 火3～4
-
Calculus （2023academic year） 1st and 2nd semester - 火1～2
-
Calculus （2023academic year） 1st and 2nd semester - 火1～2
-
Calculus （2023academic year） 1st and 2nd semester - 火1～2
-
Analysis （2023academic year） 1st and 2nd semester - 火1～2
-
Analysis （2023academic year） 1st and 2nd semester - 火1～2
-
Analysis （2023academic year） 1st and 2nd semester - 火1～2
-
Analysis 1 （2023academic year） 1st semester - 火1～2
-
Analysis 1 （2023academic year） 1st semester - 火1～2
-
Analysis 1 （2023academic year） 1st semester - 火1～2
-
Analysis 2 （2023academic year） Second semester - 火1～2
-
Analysis 2 （2023academic year） Second semester - 火1～2
-
Analysis 2 （2023academic year） Second semester - 火1～2
-
Seminar in Advanced Chemistry （2023academic year） Other - その他
-
Seminar in Advanced Chemistry （2023academic year） Other - その他
-
Mathematical and Data Sciences（Advanced） （2023academic year） Fourth semester - 火1～2
-
Organic Chemistry Ⅱ （2023academic year） 1st semester - 月1,木3
-
Organic Chemistry Ⅲ （2023academic year） 1st semester - 月2,木4
-
Organic Chemistry Ⅳ （2023academic year） Third semester - 月1,木5
-
Organic Chemistry Ⅴ （2023academic year） Third semester - 月2,木6
-
Organic Chemistry I （2023academic year） Second semester - 金3～4
-
Materials Process Engineering 1 （2023academic year） Prophase - その他
-
Materials Process Engineering 2 （2023academic year） Prophase - その他
-
Materials and Reaction Process Engineering （2023academic year） Late - 火1～2
-
Instrumental Analysis for Chemistry Ⅱ （2023academic year） Fourth semester - 水3～4
-
Instrumental Analysis for Chemistry I （2023academic year） Third semester - 水3～4
-
Thermodynamic Description of Mixtures （2023academic year） 1st semester - 月4,木2
-
Inorganic Chemistry II （2023academic year） Fourth semester - 水3～4
-
Inorganic Chemistry I （2023academic year） Third semester - 水3～4
-
Inorganic Materials Chemistry （2023academic year） Third semester - 火4,金2
-
Inorganic Crystal Chemistry （2023academic year） Third semester - 火3,金1
-
Heat and Mass Balances （2023academic year） 1st semester - 月7～8
-
Thermodynamics II （2023academic year） Second semester - 水3～4
-
Thermodynamics III （2023academic year） 1st semester - 月3,木1
-
Physical Chemistry 1 （2023academic year） 1st and 2nd semester - [第１学期]水1～2, [第２学期]水3～4
-
Physical Chemistry 1 （2023academic year） 1st and 2nd semester - [第１学期]水1～2, [第２学期]水3～4
-
Advanced Study （2023academic year） Other - その他
-
Special Research （2023academic year） Year-round - その他
-
Environmental Process Engineering （2023academic year） Prophase - その他
-
Process Engineering for Environmental Science （2023academic year） Late - 木3～4
-
Seminar in Environmental Process Engineering （2023academic year） Prophase - その他
-
Seminar in Environmental Process Engineering （2023academic year） Late - その他
-
Seminar in Environmental Process Engineering （2023academic year） Late - その他
-
Seminar in Environmental Process Engineering （2023academic year） Prophase - その他
-
Seminar in Environmental Process Engineering （2023academic year） Year-round - その他
-
Process Design for Environment （2023academic year） Prophase - その他
-
Analytical Chemistry in Environmental Fields Ⅱ （2023academic year） Second semester - 水1～2
-
Basic Experiments in Analytical Chemistry （2023academic year） 1st and 2nd semester - 月5～8,木5～8
-
Analytical Chemistry in Environmental Fields I （2023academic year） 1st semester - 水1～2
-
Experiments and Exercises in Environmental Chemistry A （2023academic year） 1-3 semesters - [第１学期]月5～6,木5～6, [第２学期]その他, [第３学期]火5～6,金5～6
-
Experiments and Exercises in Environmental Chemistry B （2023academic year） 1-3 semesters - [第１学期]月7～8,木7～8, [第２学期]その他, [第３学期]火7～8,金7～8
-
Experiments and Exercises in Environmental Chemistry C （2023academic year） 1-3 semesters - その他
-
Chemical Technology to Solve Environmental Problems （2023academic year） 1st semester - 月3～4
-
Environmental Organic Chemistry Ⅱ （2023academic year） Second semester - 火1～2,金3～4
-
Environmental Organic Chemistry I （2023academic year） Fourth semester - 木5～6
-
Topics in Environmental Chemistry and Materials C （2023academic year） Summer concentration - その他
-
Biochemiacl Engineering （2023academic year） Late - その他
-
Biointerface Engineering （2023academic year） Late - その他
-
Phase Equilibria （2023academic year） Third semester - 月3,木1
-
Seminar on Laboratory Work （2023academic year） 1st-4th semester - その他
-
Seminar on Laboratory Work （2023academic year） Other - その他
-
Probability and Statistics 2 （2023academic year） Fourth semester - 火1～2
-
Statistics I （2023academic year） Fourth semester - 火1～2
-
Linear Algebra （2023academic year） 1st and 2nd semester - 金5～6
-
Linear Algebra （2023academic year） 1st and 2nd semester - 金5～6
-
Linear Algebra （2023academic year） 1st and 2nd semester - 金5～6
-
Linear Algebra （2023academic year） 1st and 2nd semester - 金5～6
-
Linear Algebra 1 （2023academic year） 1st semester - 金5～6
-
Linear Algebra 1 （2023academic year） 1st semester - 金5～6
-
Linear Algebra 2 （2023academic year） Second semester - 金5～6
-
Linear Algebra 2 （2023academic year） Second semester - 金5～6
-
Electrochemistry II （2023academic year） Third semester - 月4,木2
-
Electrochemistry I （2023academic year） Second semester - 月1,木3
-
Polymer Chemistry I （2023academic year） 1st semester - 月1,木3
-
Solid State Science of Polymer （2023academic year） Fourth semester - 木1～2
-
Thermodynamics of Polymer Solution （2023academic year） Third semester - 木1～2
-
Advances in Material and Energy Science （2022academic year） special - その他
-
Environmental Process Engineering （2022academic year） 1st semester - 月7～8
-
SDGs:Energy and Entropy （2022academic year） Third semester - 月7～8
-
Energy and Entropy （2022academic year） Third semester - 月7～8
-
Design of Chemical Process Ⅱ （2022academic year） Third semester - その他
-
Design of Chemical Process I （2022academic year） Third semester - その他
-
Chemical Process Engineering Ⅱ （2022academic year） Fourth semester - 月3～4
-
Chemical Process Engineering I （2022academic year） Third semester - 月3～4
-
Safety for Chemistry Experiments （2022academic year） 1st semester - 火1～2
-
Lecture and Exercises for Safety in Chemical Experiments （2022academic year） 1st semester - 火1～2
-
Chemical Engineering I （2022academic year） Fourth semester - 水1～2
-
Chemical Reaction Engineering I （2022academic year） Third semester - 金1～2
-
Chemical Reactions and Its Dynamics （2022academic year） Third semester - 火1～2
-
Fundamental of Chemical Engineering （2022academic year） Third semester - 水1～2
-
Fundamentals of Organic Chemistry （2022academic year） 1st semester - 金3～4
-
Fundamental Inorganic Chemistry （2022academic year） Second semester - 月2,木4
-
Fundamental of Physical Chemistry （2022academic year） 1st semester - 金1～2
-
Exercise in Basic English （2022academic year） Second semester - 水4
-
Exercise in Basic English （2022academic year） 1st semester - 水4
-
Exercise in Basic English （2022academic year） 1st semester - 水8
-
Exercise in Basic English （2022academic year） Third semester - 水4
-
Exercise in Basic English （2022academic year） Fourth semester - 水4
-
Analysis （2022academic year） 1st and 2nd semester - 金5～6
-
Calculus （2022academic year） 1st and 2nd semester - 金5～6
-
Analysis 1 （2022academic year） 1st semester - 金5～6
-
Analysis 2 （2022academic year） Second semester - 金5～6
-
Mathematical and Data Sciences（Advanced） （2022academic year） Fourth semester - 火1～2
-
Organic Chemistry Ⅱ （2022academic year） 1st semester - 月1,木3
-
Organic Chemistry Ⅲ （2022academic year） 1st semester - 月2,木4
-
Organic Chemistry I （2022academic year） Second semester - 金3～4
-
Thermodynamic Description of Mixtures （2022academic year） 1st semester - 月4,木2
-
Thermodynamics II （2022academic year） Second semester - 水3～4
-
Thermodynamics III （2022academic year） 1st semester - 月3,木1
-
Thermodynamics I （2022academic year） 1st semester - 水3～4
-
Physical Chemistry 1 （2022academic year） 1st and 2nd semester - 水3～4
-
Physical Chemistry 1 （2022academic year） 1st and 2nd semester - 水3～4
-
Special Research （2022academic year） Year-round - その他
-
Environmental Process Engineering （2022academic year） 1st semester - 月7～8
-
Process Engineering for Environmental Science （2022academic year） Late - 木3～4
-
Seminar in Environmental Process Engineering （2022academic year） Late - その他
-
Seminar in Environmental Process Engineering （2022academic year） Prophase - その他
-
Seminar in Environmental Process Engineering （2022academic year） Prophase - その他
-
Seminar in Environmental Process Engineering （2022academic year） Late - その他
-
Process Design for Environment （2022academic year） Prophase - その他
-
Analytical Chemistry in Environmental Fields Ⅱ （2022academic year） Second semester - 水1～2
-
Analytical Chemistry in Environmental Fields I （2022academic year） 1st semester - 水1～2
-
Chemical Technology to Solve Environmental Problems （2022academic year） 1st semester - 月3～4
-
Topics in Environmental Chemistry and Materials C （2022academic year） Summer concentration - その他
-
Seminar on Laboratory Work （2022academic year） 1st-4th semester - その他
-
Seminar on Laboratory Work （2022academic year） Other - その他
-
Probability and Statistics 2 （2022academic year） Fourth semester - 火1～2
-
Statistics I （2022academic year） Fourth semester - 火1～2
-
Heat and Mass Balances （2021academic year） 1st semester - 火7,火8
-
SDGs:Energy and Entropy （2021academic year） Third semester - 月7～8
-
Energy and Entropy （2021academic year） Third semester - 月7～8
-
Energy and Entropy （2021academic year） Third semester - 月7～8
-
Design of Chemical Process （2021academic year） Third semester - その他
-
Design of Chemical Process Ⅱ （2021academic year） Third semester - その他
-
Design of Chemical Process I （2021academic year） Third semester - その他
-
Chemical Process Engineering （2021academic year） 3rd and 4th semester - 月3～4
-
Chemical Process Engineering Ⅱ （2021academic year） Fourth semester - 月3～4
-
Chemical Process Engineering I （2021academic year） Third semester - 月3～4
-
Basic of Applied Chemistry and Biotechnology （2021academic year） 1st semester - 金1～2
-
Safety for Chemistry Experiments （2021academic year） 1st semester - 火1～2
-
Lecture and Exercises for Safety in Chemical Experiments （2021academic year） 1st semester - 火1～2
-
Chemical Engineering A （2021academic year） 1st-4th semester - [第１学期]木5～6, [第２学期]その他, [第３学期]その他, [第４学期]金7～8
-
Chemical Engineering A （2021academic year） 1st-4th semester - [第１学期]木5～6, [第２学期]その他, [第３学期]その他, [第４学期]金7～8
-
Chemical Engineering I （2021academic year） 1st semester - 木5～6
-
Chemical Reaction Engineering （2021academic year） 3rd and 4th semester - [第３学期]金1～2, [第４学期]金3～4
-
Chemical Reaction Engineering I （2021academic year） Third semester - 金1～2
-
Fundamental of Chemical Engineering （2021academic year） Fourth semester - 金7～8
-
Fundamentals of Organic Chemistry （2021academic year） 1st semester - 金3～4
-
Fundamental of Physical Chemistry （2021academic year） 1st semester - 金7～8
-
Fundamental of Physical Chemistry （2021academic year） 1st semester - 金7～8
-
Fundamental of Physical Chemistry （2021academic year） 1st semester - 金1～2
-
Exercise in Basic English （2021academic year） Fourth semester - 水4
-
Exercise in Basic English （2021academic year） Third semester - 水4
-
Exercise in Basic English （2021academic year） Second semester - 水8
-
Exercise in Basic English （2021academic year） Second semester - 水4
-
Exercise in Basic English （2021academic year） 1st semester - 水8
-
Exercise in Basic English （2021academic year） 1st semester - 水4
-
Mathematical and Data Sciences（Advanced） （2021academic year） Fourth semester - 火1,火2
-
Heat and Mass Balances （2021academic year） 1st semester - 火7～8
-
Thermodynamics I （2021academic year） 1st semester - 水3～4
-
Physical Chemistry 1 （2021academic year） 1st and 2nd semester - 水3,水4
-
Special Research （2021academic year） Year-round - その他
-
International internship for manufacturing in consideration of environment （2021academic year） Summer concentration - その他
-
Process Engineering for Environmental Science （2021academic year） Late - 木3～4
-
Seminar in Environmental Process Engineering （2021academic year） Prophase - その他
-
Seminar in Environmental Process Engineering （2021academic year） Late - その他
-
Seminar in Environmental Process Engineering （2021academic year） Late - その他
-
Seminar in Environmental Process Engineering （2021academic year） Prophase - その他
-
Process Design for Environment （2021academic year） Prophase - その他
-
Chemical Technology to Solve Environmental Problems （2021academic year） 1st semester - 月3～4
-
Seminar on Laboratory Work （2021academic year） 1st-4th semester - その他
-
Seminar on Laboratory Work （2021academic year） Other - その他
-
Probability and Statistics 2 （2021academic year） Fourth semester - 火1,火2
-
Liberal Arts and Practice in Natural and Environmental Sciences （2021academic year） Late - 木7,木8
-
Experimental learning of environmental problems and English in New Zealand （2021academic year） Summer concentration - その他
-
Foundation of SDGs and ESD （2021academic year） Summer concentration - その他
-
Advances in Material and Energy Science （2020academic year） Summer concentration - その他
-
Environmental Process Engineering （2020academic year） 1st semester - 火7,火8
-
Energy and Entropy （2020academic year） Fourth semester - 火3,金1,金2
-
Energy and Entropy （2020academic year） Fourth semester - 火3,金1,金2
-
Energy and Entropy （2020academic year） Fourth semester - 火3,金1,金2
-
Design of Chemical Process （2020academic year） Third semester - その他
-
Design of Chemical Process Ⅱ （2020academic year） Third semester - その他
-
Design of Chemical Process I （2020academic year） Third semester - その他
-
Chemical Process Engineering （2020academic year） 3rd and 4th semester - 月4,月5
-
Chemical Process Engineering Ⅱ （2020academic year） Fourth semester - 月4,月5
-
Chemical Process Engineering I （2020academic year） Third semester - 月4,月5
-
Chemical Engineering A （2020academic year） 1st-4th semester - [第１学期]木4,木5, [第２学期]その他, [第３学期]その他, [第４学期]金6,金7
-
Chemical Engineering I （2020academic year） 1st semester - 木4,木5
-
Chemical Reaction Engineering （2020academic year） 3rd and 4th semester - 金1,金2
-
Chemical Reaction Engineering I （2020academic year） Third semester - 金1,金2
-
Fundamental of Chemical Engineering （2020academic year） Fourth semester - 金6,金7
-
Fundamental of Physical Chemistry （2020academic year） 1st semester - 金4,金5
-
Fundamental of Physical Chemistry （2020academic year） 1st semester - 金4,金5
-
Fundamental of Physical Chemistry （2020academic year） 1st semester - 金4,金5
-
Exercise in Basic English （2020academic year） 1st semester - 水4
-
Exercise in Basic English （2020academic year） Fourth semester - 水4
-
Exercise in Basic English （2020academic year） Third semester - 水5
-
Exercise in Basic English （2020academic year） Third semester - 水4
-
Exercise in Basic English （2020academic year） Second semester - 水4
-
Thermodynamics （2020academic year） 3rd and 4th semester - 火4,火5
-
Thermodynamics II （2020academic year） Third semester - 火4,火5
-
Thermodynamics III （2020academic year） Fourth semester - 火4,火5
-
Special Research （2020academic year） Year-round - その他
-
Present Environmental Problems, Science and Technology （2020academic year） Fourth semester - 木5,木6
-
International internship for manufacturing in consideration of environment （2020academic year） Summer concentration - その他
-
Process Engineering for Environmental Science （2020academic year） Late - 木2,木3
-
Environmental Process Engineering （2020academic year） 1st semester - 火7,火8
-
Seminar in Environmental Process Engineering （2020academic year） Prophase - その他
-
Seminar in Environmental Process Engineering （2020academic year） Late - その他
-
Seminar in Environmental Process Engineering （2020academic year） Late - その他
-
Seminar in Environmental Process Engineering （2020academic year） Prophase - その他
-
Process Design for Environment （2020academic year） Prophase - その他
-
Environmental analytical Chemistry （2020academic year） 3rd and 4th semester - 火6,火7
-
Analytical Chemistry in Environmental Fields Ⅱ （2020academic year） Fourth semester - 火6,火7
-
Analytical Chemistry in Environmental Fields I （2020academic year） Third semester - 火6,火7
-
Chemical Technology to Solve Environmental Problems （2020academic year） 1st semester - 月3,月4
-
Topics in Environmental Chemistry and Materials C （2020academic year） Summer concentration - その他
-
Topics in Environmental Chemistry and Materials I （2020academic year） Summer concentration - その他
-
Seminar on Laboratory Work （2020academic year） 1st-4th semester - その他
-
Seminar on Laboratory Work （2020academic year） Other - その他
-
Liberal Arts and Practice in Natural and Environmental Sciences （2020academic year） Late - 木7,木8
-
Experimental learning of environmental problems and English in New Zealand （2020academic year） Summer concentration - その他
-
Foundation of SDGs and ESD （2020academic year） Spring concentration - その他
Social Activities
-
赤磐市地球温暖化対策実行計画推進協議会委員
Role(s)：Organizing member
赤磐市 2024.9.12 - 2026.9.11
-
岡山県環境審議会委員
岡山県 2024.9.1 - 2026.8.31