2021/12/28 更新

写真a

カワヅ トシユキ
河津 俊幸
KAWAZU Toshiyuki
所属
医歯薬学域 准教授
職名
准教授
外部リンク

学位

  • 歯学博士 ( 2002年3月   九州大学 )

研究キーワード

  • Oral&Maxillofacial Radiology

  • 歯科放射線学

研究分野

  • ライフサイエンス / 病態系口腔科学

学歴

  • 九州大学   Faculty of Dentistry  

    - 1995年

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  • 九州大学   School of Dentistry  

    - 1995年

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    国名: 日本国

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経歴

  • 岡山大学   医歯薬学総合研究科 歯科放射線学分野   准教授

    2019年4月 - 現在

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  • 九州大学病院   口腔画像診断科   助教

    2004年4月 - 2019年3月

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  • 九州大学歯学部付属病院   歯科放射線科   助手

    1997年4月 - 2004年3月

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所属学協会

委員歴

  • 日本歯科放射線学会   代議員  

    2019年4月 - 現在   

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    団体区分:学協会

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  • 日本歯科放射線学会   和文誌編集委員  

    2014年4月 - 現在   

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    団体区分:学協会

    日本口腔腫瘍学会

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論文

  • Dynamic contrast-enhanced MRI as a predictor of programmed death ligand-1 expression in patients with oral squamous cell carcinoma

    Nouha Tekiki, Mariko Fujita, Tatsuo Okui, Hotaka Kawai, May Oo, Toshiyuki Kawazu, Miki Hisatomi, Shunsuke Okada, Yohei Takeshita, Majd Barham, Hitoshi Nagatsuka, Yoshinobu Yanagi, Jun-Ichi Asaumi

    ONCOLOGY LETTERS   22 ( 5 )   2021年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPANDIDOS PUBL LTD  

    Immune checkpoint inhibitors (ICIs) targeting programmed death ligand-1 (PD-L1) are highly promising therapies for oral squamous cell carcinoma (OSCC). The assessment of PD-L1 expression may help predicting the therapeutic effect of ICIs and, thus, benefit patient selection. Contrast index (CI) parameters derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) have been proven as efficient to assess microvessel density (MVD) in OSCC. The present study aimed to determine the correlation between DCE-MRI parameters and MVD and between DCE-MRI parameters and PD-L1 expression to determine whether DCE-MRI could be used non-invasively to evaluate PD-L1 expression in patients with OSCC. A total of 21 patients with primary OSCC who had undergone a 3T MRI scan, including DCE-MRI, were included in the present study, and CI curve-derived parameters were examined. The MVD and PD-L1 expression in the surgically resected specimens were analyzed using immunohistochemistry (IHC) staining for CD31 and IHC staining for PD-L1, respectively. The results demonstrated that the expression levels of these markers were correlated with DCE-MRI parameters. PD-L1 expression levels were found to be significantly correlated with the maximum CI (CI-max; P=0.007), peak CI (CI-peak; P=0.007), maximum CI gain (CI-gain; P=0.006) and MVD (P=0.001) values. The mean CI-max, CI-peak, CI-gain and MVD values were significantly higher in tumors with high PD-L1 expression (P<0.05). MVD levels were also significantly correlated with the time of CI-max (T-max; P=0.003) and CI-gain (P=0.037). The mean CI-gain was significantly increased, and the mean T-max was significantly shorter in high MVD tumors (P<0.05 and P<0.01, respectively). In summary, the findings from the present study confirmed the correlation between CI parameters, derived from DCE-MRI, and MVD, and suggested that these parameters may be correlated with PD-L1 expression in OSCC tumor cells.

    DOI: 10.3892/ol.2021.13039

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  • The potential for facial artery injury during mandibular third molar extraction. An anatomical study using contrast-enhanced computed tomography. 国際誌

    Yohei Takeshita, Soichiro Ibaragi, Hirokazu Yutori, Jingo Kusukawa, R Shane Tubbs, Toshiyuki Kawazu, Junichi Asaumi, Joe Iwanaga

    Clinical anatomy (New York, N.Y.)   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The purpose of this study was to evaluate the risk of injury to the facial (FA) and related arteries during mandibular third molar (MTM) extraction using contrast-enhanced computed tomography (CE-CT). CE-CT images of the MTM region were retrospectively reviewed. The area of the MTM was equally divided into three zones in the coronal images from mesial to distal, that is, zone 1, zone 2, and zone 3. The FA, submental artery (SMA), and sublingual artery (SLA) were identified. The distance from the mandible to FA, SMA, and SLA and the diameter of the FA, SMA, and SLA was measured in three zones, respectively. The thickness of the facial soft tissues and width of the mandible were measured at their maximum. The mean distance from the FA to the buccal cortical bone in zone 1, zone 2 and zone 3 was 2.24 mm, 2.39 mm and 1.67 mm, respectively. The SMA and SLA were found to be distal to the mandible. The mean diameter of the FA was 1.26 mm in males and 1.04 mm in females, respectively (p < 0.0001). The distance between the FA and buccal cortical bone of the mandible, and the patients' weight showed moderate correlation in zones 1 and 2. Based on our findings, the FA can be damaged if the surgical invasion reaches the facial soft tissues during MTM surgery. The patients' weight might be a good predictor for FA injury when CE-CT is not available.

    DOI: 10.1002/ca.23779

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  • Assessment of Hounsfield unit in the differential diagnosis of odontogenic cysts. 国際誌

    Kyonori Uehara, Miki Hisatomi, Luciana Munhoz, Toshiyuki Kawazu, Yoshinobu Yanagi, Shunsuke Okada, Yohei Takeshita, Emiko Arita Saito, Junichi Asaumi

    Dento maxillo facial radiology   50 ( 2 )   20200188 - 20200188   2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVES: The purpose of this study was to evaluate the usefulness of Hounsfield unit (HU) assessment with multislice-CT in the differentiation of radicular cysts (RCs), dentigerous cysts (DCs) and odontogenic keratocysts (OKCs). METHODS: In total, 307 odontogenic cysts (RCs, DCs and OKCs) were included in this study. Cysts with lesion diameter <10 mm, cysts with artefacts affecting measurement of HU values, cysts involving infection and recurrent cysts were regarded as exclusion criteria. Images were acquired in three different types of CT scanners: Aquilion ONE, Discovery CT750 HD and SOMATOM Definition Flash. Differences in HU values among scanners and among types of odontogenic cysts were assessed using one-way analysis of variance; multiple comparisons were performed post hoc, using the Tukey-Kramer honestly significant difference test. RESULTS: In total, 164 cysts were analysed in this study (64 RCs, 57 DCs and 43 OKCs). Regardless of the type of lesion, the Aquilion ONE scanner demonstrated a significant difference in HU value, compared with the Discovery CT750 HD scanner. Regardless of CT scanner model, HU values significantly differed between DCs and OKCs (p < 0.0001), as well as between OKCs and RCs (p < 0.0001). CONCLUSIONS: HU values were found to vary among CT scanners and should always be associated with other lesion imaging features while interpreting and elaboration diagnostic hypothesis. Notably, the results suggested that OKCs might be able to be differentiated from DCs and RCs by using HU values.

    DOI: 10.1259/dmfr.20200188

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  • Prediction of nodal metastasis based on intraoral sonographic findings of primary lesion in early-stage tongue cancer

    Shintaro Kawano, Taichi Hattori, Yurie Mikami, Toru Chikui, Toshiyuki Kawazu, Taiki Sakamoto, Yasuyuki Maruse, Shoichi Tanaka, Eiki Hamada, Megumi Hiwatashi, Yurika Shiraishi, Kazunari Oobu, Tamotsu Kiyoshima, Seiji Nakamura

    International Journal of Oral and Maxillofacial Surgery   in print   2020年6月

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  • Incidental findings in the thyroid gland on computed tomography images of the oral and maxillofacial region

    Abdullah Khasawneh, Yohei Takeshita, Miki Hisatomi, Toshiyuki Kawazu, Mariko Fujita, Shunsuke Okada, Yuri Namba, Yudai Shimizu, Yoshinobu Yanagi, Junichi Asaumi

    ONCOLOGY LETTERS   19 ( 3 )   2005 - 2010   2020年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPANDIDOS PUBL LTD  

    The numbers of abnormal findings incidentally detected in adjacent regions are increasing with advances in imaging modalities. The present study aimed to examine the prevalence and characteristics of incidental findings in the thyroid gland on computed tomography (CT) images of the oral and maxillofacial region. CT scans of the oral and maxillofacial region in patients obtained between January 2012 and December 2016 were retrospectively reviewed. Images that revealed incidental findings in the thyroid gland, including nodules, were recorded, together with the sizes and characteristics of the findings. The Japan Association of Breast and Thyroid Sonology (JABTS) guidelines were used for classification. The rate of descriptions of these findings in the radiographic interpretation reports were also examined. Of the 1,135 patients examined, 326 (28.7%) had several types of incidental findings. In particular, 169 (14.9%) of the 1,135 patients had nodules >5 mm in diameter, for which further careful examination is recommended in the JABTS guideline. The description rate for nodules >5 mm in diameter in the radiographic interpretation reports was 30.8% (52/169 patients), of whom 17.3% (9/52 patients) were referred to the endocrinology department for further careful examination. Incidental findings in the thyroid gland were relatively common on CT images of the oral and maxillofacial region. Oral radiologists tend to focus specifically on the oral and maxillofacial region during diagnosis on oral and maxillofacial CT images, but should pay the same careful attention to observe adjacent regions, such as the thyroid gland.

    DOI: 10.3892/ol.2020.11298

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  • 鼻咽腔に発生した若年性血管線維腫3例の比較検討

    清水 雄大, 村上 純, 河津 俊幸, 久富 美紀, 藤田 麻里子, 竹下 洋平, 岡田 俊輔, 難波 友里, 柳 文修, 浅海 淳一

    歯科放射線   59 ( 増刊 )   57 - 57   2019年6月

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    記述言語:日本語   出版者・発行元:(NPO)日本歯科放射線学会  

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  • 舌エコーの画像所見による潜在的頸部リンパ節転移の予測

    服部 多市, 川野 真太郎, 三上 友里恵, 筑井 徹, 河津 俊幸, 松原 良太, 後藤 雄一, 金子 直樹, 坂本 泰基, 橋口 有真, 神野 哲平, 丸瀬 靖之, 田中 翔一, 大部 一成, 中村 誠司

    日本口腔科学会雑誌   67 ( 2 )   200 - 201   2018年7月

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    記述言語:日本語   出版者・発行元:(NPO)日本口腔科学会  

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  • Estimation of prognosis of tongue cancer using tumor depth and margin shape obtained from ultrasonography 査読

    Sitti Fadhillah Oemar Mattalitti, Toshiyuki Kawazu, Shintaro Kawano, Tatsuya Ikari, Hiroko Wada, Kazunori Yoshiura

    ORAL RADIOLOGY   33 ( 2 )   101 - 107   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    To evaluate the feasibility of using ultrasound-obtained tumor depth (TD) and margin shape (MS) to predict the prognosis of tongue cancer.
    Fifty-two Japanese patients with tongue cancer who underwent ultrasound examination between 2007 and 2012 were retrospectively evaluated. TD was measured at the deepest portion of the tumor. MS was classified as "pressure," "wedge-shaped," or "permeated." Prognosis was assessed by local recurrence, lymph node metastasis, and overall survival rate. We classified the patients into a good prognosis group and poor prognosis group. Relationships among TD, MS, and patient prognosis were evaluated using Spearman rank correlation. A regression formula to predict prognosis using TD and MS was derived.
    The correlation between TD and MS was significant (Spearman rank correlation rho = 0.552, p &lt; 0.01). Using a structure matrix, we identified the contribution of both predictors from an ultrasound image. The contribution of TD was 0.796, while that of MS was better at 0.906. The prognosis could be predicted using the following regression formula: , where D prognosis (risk probability), x = TD (mm), and y = MS (grade). The average value for good risk probability was -0.254 (standard deviation, 0.962), while that for poor risk probability was 0.566 (standard deviation, 1.08) (p &lt; 0.05). The cut-off value for classifying cases was -0.00169. Using the formula above, 73.1 % of patients in the poor prognosis group were correctly classified.
    MS and TD are useful predictors of tongue cancer prognosis.

    DOI: 10.1007/s11282-016-0251-y

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  • 巨舌を呈した舌対称性脂肪腫症の1例

    見立 英史, 川野 真太郎, 清島 保, 三上 友里恵, 後藤 雄一, 河津 俊幸, 池邉 哲郎, 中村 誠司

    日本口腔腫瘍学会誌   28 ( 4 )   293 - 298   2016年12月

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    記述言語:日本語   出版者・発行元:(一社)日本口腔腫瘍学会  

    舌対称性脂肪腫症(SLT)は、成熟した脂肪組織が両側の舌筋内へ浸潤性増殖する疾患と定義される。今回われわれは、巨舌を呈したSLTの症例を経験したので、文献的考察を加えて報告する。患者は、両側舌縁部に無痛性で弾性軟、多発性の腫瘤を認めた71歳の男性である。舌縁部の外向性腫瘤により、患者の舌幅は下顎の歯列弓幅よりも広く、いわゆる巨舌を呈していた。両側舌縁部の腫瘤は、MRIのT1およびT2強調画像で高信号、T2脂肪抑制像で信号低下を示した。生検組織の病理組織学的診断は脂肪腫であった。病変が対称性はないものの、両側の舌縁部にあることから、SLTと診断した。慢性心房細動に対して抗凝固薬を内服しており、術後の出血および腫脹による気道閉塞が懸念されたため、左右2回に分けて全身麻酔下に腫瘍減量術を行った。切除物の病理組織検査では、成熟した脂肪組織が舌筋組織内へ浸潤性増殖している所見がみられ、病理組織学的診断はSLTであった。術後2年経過したが、増大所見は認めない。(著者抄録)

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  • Dentigerous cysts with calcification mimicking odontogenic tumors: differential diagnosis by CT 査読

    Mayumi Shimizu, Dai Ogawa, Kazutoshi Okamura, Toshiyuki Kawazu, Toru Chikui, Kazunori Yoshiura

    ORAL RADIOLOGY   31 ( 1 )   14 - 22   2015年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    This study aimed at clarifying whether we can differentiate dentigerous cysts with calcified substances from other odontogenic tumors that include calcification and the crown of an unerupted tooth by CT findings.
    We retrospectively selected histopathologically confirmed cases that included calcified substances and the crown of an unerupted tooth inside. There were 22 cases with eight pathological categories. Besides seven odontogenic tumors, we included dentigerous cysts, which were usually recognized without calcification within the lesions. We divided the cases into two groups: 14 cases of odontogenic tumors and 8 cases of dentigerous cysts. Cases were analyzed for various CT findings such as continuity with the alveolar crest, bone sclerosis around the lesion, and sizes and shapes of high CT value substances, as well as demographic factors. Comparisons between the groups for each analytical factor were performed.
    Dentigerous cysts with dystrophic calcification showed unique CT findings such as bone sclerosis around the lesion, continuity with the alveolar crest, and small scattered calcified substances near the crown of an unerupted tooth, compared with typical dentigerous cysts and other odontogenic tumors. On the other hand, odontogenic tumors showed various patterns in the location and distribution of high CT value substances, and we could only differentiate odontoma using its very high CT values.
    Although the patterns of calcification were not the main characteristic findings, it may be possible to differentiate dentigerous cysts with dystrophic calcification from odontogenic tumors by their other characteristic CT findings, and unnecessary extensive surgery can also be avoided.

    DOI: 10.1007/s11282-014-0173-5

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  • Carcinoma ex pleomorphic adenoma of the upper lip: a case of an unusual malignant component of squamous cell carcinoma. 国際誌

    Eiji Mitate, Shintaro Kawano, Tamotsu Kiyoshima, Toshiyuki Kawazu, Toru Chikui, Yuichi Goto, Ryota Matsubara, Seiji Nakamura

    World journal of surgical oncology   11   234 - 234   2013年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Squamous cell carcinoma (SCC) as the malignant component of carcinoma ex pleomorphic adenoma (CXPA) occurring in upper lip is rare. CASE REPORT: A 55-year-old male patient presented with an asymptomatic mass of the upper lip that had noticed 8 years previously. The mass was clinically suspected to be a benign salivary gland tumor based on palpation and magnetic resonance imaging findings. A needle biopsy was then carried out, and the pathological diagnosis was pleomorphic adenoma. The tumor was removed under general anesthesia. Histopathological examination revealed well-demarcated tumor tissues showing typical histologic features of pleomorphic adenoma. However, SCC tissue with several mitotic figures was found in the central area of the tumor tissue. The tumor was finally diagnosed as CXPA. There was no evidence of recurrence or metastasis 6 years postoperatively. CONCLUSION: This is the first report of CXPA of the upper lip with an unusual malignant component of SCC.

    DOI: 10.1186/1477-7819-11-234

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  • Carcinoma ex pleomorphic adenoma of the upper lip: A case of an unusual malignant component of squamous cell carcinoma

    Eiji Mitate, Shintaro Kawano, Tamotsu Kiyoshima, Toshiyuki Kawazu, Toru Chikui, Yuichi Goto, Ryota Matsubara, Seiji Nakamura

    World Journal of Surgical Oncology   11   2013年9月

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    掲載種別:研究論文(学術雑誌)  

    Background: Squamous cell carcinoma (SCC) as the malignant component of carcinoma ex pleomorphic adenoma (CXPA) occurring in upper lip is rare.Case report: A 55-year-old male patient presented with an asymptomatic mass of the upper lip that had noticed 8 years previously. The mass was clinically suspected to be a benign salivary gland tumor based on palpation and magnetic resonance imaging findings. A needle biopsy was then carried out, and the pathological diagnosis was pleomorphic adenoma. The tumor was removed under general anesthesia. Histopathological examination revealed well-demarcated tumor tissues showing typical histologic features of pleomorphic adenoma. However, SCC tissue with several mitotic figures was found in the central area of the tumor tissue. The tumor was finally diagnosed as CXPA. There was no evidence of recurrence or metastasis 6 years postoperatively.Conclusion: This is the first report of CXPA of the upper lip with an unusual malignant component of SCC. © 2013 Mitate et al.; licensee BioMed Central Ltd.

    DOI: 10.1186/1477-7819-11-234

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  • 下顎歯肉に見られた腺扁平上皮癌の1例

    見立 英史, 大部 一成, 吉賀 大午, 川野 真太郎, 河津 俊幸, 清島 保, 豊嶋 健史, 北村 亮二, 中村 誠司

    日本口腔腫瘍学会誌   24 ( 2 )   55 - 61   2012年6月

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    記述言語:日本語   出版者・発行元:(一社)日本口腔腫瘍学会  

    腺扁平上皮癌は口腔領域ではまれな悪性腫瘍である。われわれは下顎歯肉腺扁平上皮癌の1例を経験した。症例は74歳男性。2009年1月初旬、左側下顎歯肉の疼痛と摂食障害を主訴に当科初診。初診時、左側下顎歯肉に55×25mm、弾性軟、暗紫色で易出血性の腫瘤を認めた。また左側オトガイ部に知覚鈍麻を認めた。CT画像では下顎管に達する骨吸収を認めた。頸部超音波検査で2個の左側顎下リンパ節に転移が疑われた。生検組織では扁平上皮癌の要素と、ジアスターゼ処理PAS染色にて粘液産生細胞を認める腺癌要素が見られた。以上より、左側下顎歯肉腺扁平上皮癌(T4N2bM0)と診断した。既往の間質性肺炎の状況から手術が困難であることと本人の希望により、根治的放射線化学療法としてUFT内服と放射線外照射を施行した。その後、両肺野、腹部と腋下部の皮膚に多発遠隔転移を認めた。4月末日呼吸状態悪化により永眠した。(著者抄録)

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  • Prediction and monitoring of the response to chemoradiotherapy in oral squamous cell carcinomas using a pharmacokinetic analysis based on the dynamic contrast-enhanced MR imaging findings 査読

    Toru Chikui, Shintaro Kawano, Toshiyuki Kawazu, Masamitsu Hatakenaka, Syouzou Koga, Masahiro Ohga, Yoshio Matsuo, Syunya Sunami, Tsuyoshi Sugiura, Yoshiyuki Shioyama, Makoto Obara, Kazunori Yoshiura

    EUROPEAN RADIOLOGY   21 ( 8 )   1699 - 1708   2011年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    To evaluate whether a pharmacokinetic analysis is useful for both predicting and monitoring the response to chemoradiotherapy (CRT) in oral cancer.
    Patients with oral squamous cell carcinoma treated with preoperative CRT and surgery were enrolled. They underwent dynamic contrast-enhanced MRI before (n = 23), and after CRT (n = 20). We estimated four parameters: arrival time of contrast medium (TA), exchange rate constant from the extracellular extravascular space (EES) to plasma (k(ep)), elimination of contrast medium from the central compartment (k(el)) and an amplitude scaling constant (AH) using the Brix model. The histological evaluation of the effects of CRT was performed according to Ohboshi and Shimosato's classification. We analysed the correlation between the parameters and the histological evaluation.
    The pre-CRT AH between the responders and non-responders was significantly different (P = 0.046), however, the three parameters (TA, K-ep, K-el) were not significantly different among the groups (P = 0.76, P = 0.60, P = 0.09). As AH decreased, the tumour response improved. The change in the AH between the pre- and post-CRT of responders was significantly higher than that of non-responders (P = 0.043).
    The AH, which is affected by the ratio of the EES, was an important parameter for predicting and monitoring the tumour response to CRT.

    DOI: 10.1007/s00330-011-2102-x

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  • 唾液腺腫瘍の画像診断について 招待 査読

    中山英二, 大内知之, 賀来 亨, 柴田考典, 有末 眞, 永易裕樹, 安彦善裕, 上野 繭美, 河津俊幸, 吉浦一紀, 浅香雄一郎, 上田倫弘, 山下徹郎, 仲盛健治, 平塚博義, 針谷靖史, 関口 隆

    口腔腫瘍   23 ( 3 )   59 - 68   2011年1月

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    記述言語:日本語  

    DOI: 10.5843/jsot.23.59

    CiNii Article

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  • 副耳下腺に生じた多形腺腫の1例

    見立 英史, 大部 一成, 笹栗 正明, 中村 典史, 川野 真太郎, 小林 家吉, 河津 俊幸, 中村 誠司

    日本口腔腫瘍学会誌   20 ( 4 )   291 - 296   2008年12月

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    記述言語:日本語   出版者・発行元:(一社)日本口腔腫瘍学会  

    われわれは副耳下腺の多形腺腫を経験した。2004年3月、20歳代後半の男性が右側頬部の腫瘤を主訴に来院した。MRI、超音波検査により副耳下腺部の腫瘤の存在を認めた。術前の針生検では多形腺腫が最も疑われたが、確定するにはいたらなかったため、同年9月手術により摘出した。腫瘤は耳下腺から独立して咬筋の外側にあり、顔面神経頬骨枝に囲まれていたが、容易に摘出でき、術後に顔面神経障害は認めなかった。摘出物の病理組織学的診断は多形腺腫であった。(著者抄録)

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    その他リンク: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2008&ichushi_jid=J02382&link_issn=&doc_id=20081215300008&doc_link_id=%2Fdy8ortum%2F2008%2F002004%2F008%2F0291-0296%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdy8ortum%2F2008%2F002004%2F008%2F0291-0296%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • 良性腫瘍(臨床) 当科における舌下腺腫瘍の臨床統計的検討

    梅津 健太郎, 川野 真太郎, 中尾 祐, 大部 一成, 中山 英二, 河津 俊幸, 小林 家吉, 清島 保, 中村 誠司

    日本口腔科学会雑誌   57 ( 1 )   120 - 120   2008年1月

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    記述言語:日本語   出版者・発行元:(NPO)日本口腔科学会  

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  • 悪性リンパ腫と小唾液腺癌の画像診断 所見を読み取る 2.節外性悪性リンパ腫

    中山 英二, 岡村 和俊, 大山 順子, 川野 真太郎, 小林 家吉, 清島 保, 筑井 徹, 河津 俊幸, 吉浦 一紀, 中村 誠司, 白砂 兼光

    日本口腔腫瘍学会誌   19 ( 4 )   232 - 232   2007年12月

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    記述言語:日本語   出版者・発行元:(一社)日本口腔腫瘍学会  

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  • 右側副耳下腺に生じた多形性腺腫の1例

    見立 英史, 大部 一成, 笹栗 正明, 中村 典史, 川野 真太郎, 小林 家吉, 河津 俊幸, 中村 誠司

    日本口腔腫瘍学会誌   18 ( 4 )   165 - 165   2006年12月

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    記述言語:日本語   出版者・発行元:(一社)日本口腔腫瘍学会  

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  • Patency assessment of the internal jugular vein after neck dissection

    T. Nagata, K. Matsunaga, T. Kawazu, S. Kawano, K. Oobu, M. Ohishi

    International Journal of Oral and Maxillofacial Surgery   35 ( 5 )   416 - 420   2006年5月

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    掲載種別:研究論文(学術雑誌)  

    Twenty-seven patients with oral malignant tumours, who underwent neck dissection with preservation of the internal jugular vein (IJV), were studied retrospectively to evaluate patency of the IJV. Twenty-three patients underwent ablative surgery of the primary lesion with neck dissection and 4 underwent neck dissection alone. Three patients received simple closure and skin grafting of the primary lesion, and 20 received reconstruction surgery (4 platysma flaps, 3 radial forearm flaps, 3 lateral upper arm flaps, 2 pectoralis major myocutaneous flaps and 8 rectus abdominis myocutaneous flaps). The maximum and minimum diameters of the IJV as measured on computed tomographic (CT) scans were used to assess patency. The cross-sectional area of the IJV and the ratio of its long axis to short axis (L/S ratio) were calculated. The relation between the change in IJV status and the type of flap used for reconstruction was also examined. Occlusion of the IJV was present in 3.7% of the patients, and 'narrowing' was present in 63.6%. The size of the flap significantly correlated with 'narrowing' of the IJV, suggesting that 'narrowing' was caused mainly by compression due to the flap. © 2005 International Association of Oral and Maxillofacial Surgeons.

    DOI: 10.1016/j.ijom.2005.09.004

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  • 内視鏡下唾石摘出術のためのSialendoscopyの開発とそれを使用した1例

    中山 英二, 河津 俊幸, 中村 典史, 岡村 和俊, 神田 重信, 大石 正道

    日本口腔科学会雑誌   53 ( 2 )   81 - 86   2004年

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    記述言語:日本語   出版者・発行元:Japanese Stomatological Society  

    We developed two types of fine sialendoscope, which could be introduced to the submandibular duct through the opening of sublingual caruncula. One is a sialendoscope of 1.1-mm outer-diameter (POLYDIAGNOST GmbH, Germany) with 6000-pixels optic fibers, and it has a working channel to insert a basket forceps and an irrigation channel. The other is a sialendoscope of 1.2-mm outer-diameter (FiberTech Co., Ltd., Japan) with 1600-pixels optic fibers and a working channel. Using these newly developed sialendoscopy systems and a 1.9F basket forceps (Boston Scientific Corporation, USA), we could successfully remove a sialolith of the submandibular gland of a 9-year-old girl.

    DOI: 10.11277/stomatology1952.53.81

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  • Interventional sialendoscopy: A new procedure for noninvasive insertion and a minimally invasive sialolithectomy 査読

    Eiji Nakayama, Kenji Yuasa, Mahiro Beppu, Toshiyuki Kawazu, Kazutoshi Okamura, Shigenobu Kanda

    Journal of Oral and Maxillofacial Surgery   61 ( 10 )   1233 - 1236   2003年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:W.B. Saunders  

    DOI: 10.1016/S0278-2391(03)00691-8

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  • A new, simple method of making a spacer in interstitial brachytherapy for mobile tongue cancer 査読

    Kenji Yuasa, Toshiyuki Kawazu, Masahiro Morita, Satoru Uehara, Naonobu Kunitake, Shigenobu Kanda

    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics   89 ( 4 )   519 - 521   2000年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVES: This article demonstrates a new method of making a spacer that increases the distance between the mandible and implanted radioactive sources in interstitial brachytherapy for patients with mobile tongue cancer. STUDY DESIGN: Fifty-three patients with mobile tongue cancer underwent interstitial brachytherapy with spacers made by this new technique. RESULTS: Our spacer is not difficult to create or to use. The spacer was made from a plastic splint by using thermoforming techniques and quick self-curing resin, which did not need waxing, wiring, or casting. The surface of the spacer, which comes in contact with the tongue, is smooth because it is covered with tissue-conditioning material. There were no complaints of pain from the patients. Osteoradionecrosis of the mandible developed in only 1 (1.9%) of these patients. CONCLUSIONS: This spacer is simple to make and prevented osteoradionecrosis.

    DOI: 10.1016/S1079-2104(00)70134-X

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  • Sonography for the detection of cervical lymph node metastases among patients with tongue cancer: Criteria for early detection and assessment of follow-up examination intervals 査読

    Kenji Yuasa, Toshiyuki Kawazu, Naonobu Kunitake, Satoru Uehara, Junichi Omagari, Kazunori Yoshiura, Eiji Nakayama, Shigenobu Kanda

    American Journal of Neuroradiology   21 ( 6 )   1127 - 1132   2000年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND AND PURPOSE: Because the presence of cervical metastasis is one of the factors influencing the outcome of patients with carcinoma of the head and neck, its early detection is potentially very important. The purpose of this study was to evaluate the characteristic changes of cervical metastasis revealed by sonography during follow-up and to assess an adequate interval for follow-up sonography of the neck among patients with tongue cancer. METHODS: Forty-three of 44 consecutive patients with squamous cell carcinoma of the tongue, who had undergone interstitial brachytherapy, were examined with sonography of the neck during the posttherapeutic follow-up period. RESULTS: Seventeen cervical lymph node metastases were found in 12 of 43 patients during follow-up. Of these 17 cervical metastases, 16 (94.1%) were accurately diagnosed and one (5.9%) was misdiagnosed as nonmetastatic based on sonographic findings. Sonography of the neck performed in seven patients at an interval of less than 1 month since the last follow-up imaging showed 9 (90.0%) of 10 metastases increased by up to 2 mm in short-axis diameter. Five patients who were followed up at an interval of more than 1 month since the last follow-up imaging had seven metastases increase by 3 to 8 mm in short-axis diameter or a change of echogenicity in the internal structure of lymph nodes or both. Pathologic examinations showed extranodal spread in 3 (4.2.9%) of these 7 metastases. CONCLUSION: Changes both in size and internal echogenicity can occur as quickly as 2 to 4 weeks between sonographic examinations. Therefore, in high-risk patients, or in those with suspicious sonographic findings, short-interval follow-up sonographic examinations are recommended at least during the first posttherapeutic year. Our findings suggest that follow-up sonography of the neck should be performed monthly, at least during the first posttherapeutic year.

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  • ニューラルネットワークを用いた歯原性良性腫瘍と嚢胞の画像診断(一般講演2)

    河津 俊幸, 田中 武昌, 神田 重信

    バイオメディカル・ファジィ・システム学会大会講演論文集   11   27 - 28   1998年

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    記述言語:日本語   出版者・発行元:バイオメディカル・ファジィ・システム学会  

    Aim of this study is to consider the accuracy in differentiating between benign odontogenic tumor (ameloblastoma) and cyst (odontogenic keratocyst) on CT image using neural network. In order to determine the weights and the biases of our neural network system, 53 cases (29 ameloblastomas, and 24 odontogenic keratocysts) were used for the learning mode. Another 20 cases (6 ameloblastomas, and 14 odontogenic keratocysts) were evaluated for determining the accuracy in the test mode. The result showed that the diagnostic accuracy was 85 %. It was suggested that the neural network is useful for differentiating these lesions.

    DOI: 10.24466/pacbfsa.11.0_27

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  • ファジィc-meansクラスタリングによる歯科用デジタル画像診断システムの濃度の最適化と被曝線量軽減の検討(一般講演2)

    田中 武昌, 河津 俊幸, 神田 重信

    バイオメディカル・ファジィ・システム学会大会講演論文集   11   29 - 30   1998年

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    記述言語:日本語   出版者・発行元:バイオメディカル・ファジィ・システム学会  

    Recently the digital dental imaging system (DDIS) has been developed and spread widely. The density distribution of DDIS images, however, are insufficient or inadequate. Therefore, the authors considered the density optimization of DDIS images, and applied the fuzzy reasoning and fuzzy c-means clustering algorithm for this purpose. According to our method, density distribution of most DDIS images could be improved appropriately. Moreover, this method could be applied to the dose reduction of the patients. Consequently, it was suggested that the absorbed dose could be decreased 38.3%.

    DOI: 10.24466/pacbfsa.11.0_29

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  • Morphologic analysis of odontogenic cysts with computed tomography 査読

    Kazunori Yoshiura, Yoshinori Higuchi, Kazuyuki Araki, Masanori Shinohara, Toshiyuki Kawazu, Kenji Yuasa, Osamu Tabata, Shigenobu Kanda

    Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics   83 ( 6 )   712 - 718   1997年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Mosby Inc.  

    Purpose. The purpose of this study was to analyze the effects of lesion site and epithelial keratinization on the morphologic characteristics of odontogenic cysts and clarify determinate factors for cyst morphology. Material and methods. Computed tomographic images of 92 odontogenic cysts were analyzed: 31 primordial, 31 dentigerous and 30 radicular. Thirty-four cysts were located in the maxilla (6 primordial, 10 dentigerous, and 18 radicular) and 58 in the mandible (25 primordial, 21 dentigerous, and 12 radicular). Histologically, 31 cysts showed epithelial keratinization (18 primordial and 13 dentigerous). No keratinization was seen in radicular cysts. The morphologic features of cysts were assessed by measuring long length parallel to dental arch and short length vertical to it and calculating the long/short ratio. In addition, the computed tomography pattern of the cyst was classified into unilocular, lobulated, and multilocular patterns. Appearance of the sclerotic rim and surrounding cortex were classified into three and four patterns respectively to evaluate the developmental features of the cyst. Results. As a whole, the long length of the primordial cysts was statistically larger than the other two cyst groups and resulted in a larger long/short ratio. Statistical differences of CT pattern were also seen among cyst groups. There was no preference in any cyst group for the appearance of the sclerotic rim and cortex. There were statistical differences between maxilla and mandible in short axis and long/short ratio. The maxillary cysts generally showed round shapes irrespective of their histologic characteristics. A multilocular pattern was more frequent in the keratinized group of mandibular primordial cysts. In dentigerous cysts, a multilocular pattern was seen only in the keratinized group and the long/short ratio was statistically larger
    cyst shape was elliptical along the long axis. Conclusion. Our results demonstrated morphologic differences of odontogenic cysts caused by lesion site and keratinization. The dentigerous cyst with predominant keratinization should be included in the primordial cyst (odontogenic keratocyst) group.

    DOI: 10.1016/S1079-2104(97)90325-5

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書籍等出版物

  • 解説と例題でわかる 歯科放射線テキスト

    ( 担当: 分担執筆 ,  範囲: 唾液腺)

    2021年1月 

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  • 口腔・歯・顎・顔面ポケット画像解剖

    中山 英二, 森本 泰宏( 範囲: CBCT、顎関節撮影)

    医学情報社  2019年2月  ( ISBN:9784903553764

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    総ページ数:249p   記述言語:日本語

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  • CT・MRIアトラス Update-正常解剖と読影のポイント

    ( 担当: 分担執筆 ,  範囲: 頸部リンパ節)

    医学書院  2009年11月 

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  • Computer-aided diagnosis of the jaw bone diseases

    Oral and Maxillofacial Radiology Today  2000年 

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MISC

  • 鼻咽腔に発生した若年性血管線維腫3例の比較検討

    清水雄大, 村上純, 河津俊幸, 久富美紀, 藤田麻里子, 竹下洋平, 岡田俊輔, 難波友里, 柳文修, 浅海淳一, 浅海淳一, 浅海淳一

    歯科放射線   59   2019年

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  • Intraoral sonographic features of tongue cancer after radical radiotherapy

    Toru Chikui, Toshiyuki Kawazu, Katsumasa Nakamura, Yuusuke Urashima, Kenji Yuasa, Shigenobu Kanda

    European Journal of Radiology   52 ( 3 )   246 - 256   2004年12月

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    記述言語:英語   掲載種別:書評論文,書評,文献紹介等  

    Purpose: The purpose was to illustrate the sonographic changes of tongue cancer after radical radiotherapy. Materials and methods: In 24 patients with tongue cancer treated by interstitial brachytherapy (BRT) (uneventful recovery n=16, recurrence n=5, severe soft tissue complication n=3), follow-up examination were performed and both the margin and the vascular pattern were retrospectively assessed. We basically performed US examination at least once every 3 months after BRT within 1 year during follow-up period. Results: In the healing process, intraoral sonography shows an unclear margin immediately after brachytherapy and a transient increase of the vascularity lasted within 6 months after BRT, followed by a decrease in the vascularity. The large difference in echogenicity between the primary site and the surrounding tissue and the increased difference suggested the possibility of either radiation ulceration or recurrence. Conclusion: Intraoral sonography could depict the sequence changes of the tongue after BRT, and it was thus useful to confirm the clinical findings of either radiation ulcers or recurrence. © 2004 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.ejrad.2004.01.012

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  • ニューラルネットワークを用いた口腔癌頸部リンパ節転移の画像診断 査読

    河津俊幸, 荒木和之, 吉浦一紀, 中山英二, 神田重信

    Oral Radiology   19 ( 2 )   137 - 142   2003年4月

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    担当区分:筆頭著者   記述言語:英語  

    DOI: 10.1007/BF02493239

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  • 下顎歯肉癌原発巣における腫瘍進展のCT所見による診断能

    中山 英二, 湯浅 賢治, 田畑 修, 河津 俊幸, 筑井 徹, 神田 重信, 中村 誠司, 吉川 博政, 大部 一成, 池邊 哲郎, 大石 正道, 白砂 兼光

    日本口腔腫瘍学会誌   13 ( 4 )   253 - 256   2001年12月

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  • ニューラルネットワークの画像診断への応用

    日本医用画像工学会   18(5), 698-702   2000年

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  • The change of CT and US findings of cervical lymphadenopathy in oral squamous cell carcinoma before and after preoperative chemoradiotherapy

    Toshiyuki Kawazu, Kenji Yuasa, Shigenobu Kanda, Satoru Ozeki, Masanori Shinohara

    Japan Society for Oral Tumors   11 ( 3 )   135 - 142   1999年

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  • 口腔癌の術前治療前後における頸部転移リンパ節の画像診断

    河津 俊幸, 湯浅 賢治, 神田 重信, 大関 悟, 篠原 正徳

    日本口腔腫瘍学会誌   11 ( 3 )   135 - 142   1999年

  • エナメル上皮腫と歯原性角化嚢胞のCTによる画像診断学的比較

    河津 俊幸, 荒木 和之, 吉浦 一紀, 湯浅 賢治, 神田 重信, 樋口 勝規, 大関 悟, 篠原 正徳

    歯科放射線   37 ( 3 )   211 - 218   1997年

  • Differential Diagnosis between Ameloblastoma and Odontogenic Keratocyst using Computed Tomography

    Toshiyuki KAWAZU, Kazuyuki ARAKI, Kazunori YOSHIURA, Kenji YUASA, Shigenobu KANDA, Yoshinori HIGUCHI, Satoru OHZEKI, Masanori SHINOHARA

    Dental Radiology   37 ( 3 )   211 - 218   1997年

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共同研究・競争的資金等の研究

  • Real-time Tissue Elastography of masseter muscle

    2007年

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    資金種別:競争的資金

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  • エラストグラフィを利用した咬筋内部性状の評価

    2007年

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    資金種別:競争的資金

    エラストグラフィを用いて咬筋の弾性評価を行う

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  • Interventional Radiology of Salivary gland

    2005年

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    資金種別:競争的資金

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  • 唾液腺のInterventioal Radiology

    2005年

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    資金種別:競争的資金

    種々のカテーテルを利用した唾液腺の各種疾患に対する治療

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  • CADを用いた頚部リンパ節転移の画像診断

    1995年 - 2005年

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    資金種別:競争的資金

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  • Imaging diagnosis of cervical lymph node metastasis using Computer Aided Diagnosis

    1995年 - 2005年

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    資金種別:競争的資金

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  • Differential Diagnosis between Ameloblastoma and Odontogenic Keratocyst Using Computed Tomography

    1995年 - 2000年

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    資金種別:競争的資金

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  • エナメル上皮腫と歯原性角化嚢胞のCTによる画像診断学的比較

    1995年 - 2000年

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    資金種別:競争的資金

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担当授業科目

  • 口腔診断学(実習(臨床実習)) (2021年度) 特別  - その他

  • 口腔診断学(講義・演習) (2021年度) 特別  - その他

  • 口腔顎顔面領域の画像検査 (2021年度) 第2学期  - 火2,火3

  • 放射線の発生と撮影機器 (2021年度) 第1学期  - 水2

  • 歯科医療情報管理学(実習(臨床実習)) (2021年度) 特別  - その他

  • 歯科医療情報管理学(講義・演習) (2021年度) 特別  - その他

  • 歯科放射線学I(演習・実習) (2021年度) 特別  - その他

  • 歯科放射線学I(講義・演習) (2021年度) 特別  - その他

  • 歯科放射線学II(演習・実習) (2021年度) 特別  - その他

  • 歯科放射線学II(講義・演習) (2021年度) 特別  - その他

  • 口腔診断学(実習(臨床実習)) (2020年度) 特別  - その他

  • 口腔診断学(講義・演習) (2020年度) 特別  - その他

  • 口腔顎顔面領域の画像検査 (2020年度) 第2学期  - 火2,火3

  • 歯科医療情報管理学(実習(臨床実習)) (2020年度) 特別  - その他

  • 歯科医療情報管理学(講義・演習) (2020年度) 特別  - その他

  • 歯科放射線学I(演習・実習) (2020年度) 特別  - その他

  • 歯科放射線学I(講義・演習) (2020年度) 特別  - その他

  • 歯科放射線学II(演習・実習) (2020年度) 特別  - その他

  • 歯科放射線学II(講義・演習) (2020年度) 特別  - その他

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