Updated on 2025/12/23

写真a

 
KAWAZU Toshiyuki
 
Organization
Faculty of Medicine, Dentistry and Pharmaceutical Sciences Associate Professor
Position
Associate Professor
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Degree

  • Doctor of Medical Dentistry ( 2002.3   Kyushu University )

Research Interests

  • Oral&Maxillofacial Radiology

  • 歯科放射線学

Research Areas

  • Life Science / Oral pathobiological science

Education

  • Kyushu University    

    - 1995

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  • Kyushu University   歯学部   歯学

    - 1995

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    Country： Japan

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Research History

  • Okayama University   医歯薬学総合研究科 歯科放射線学分野   Associate Professor

    2019.4

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  • Kyushu university hospital   Oral & maxillofacial radiology   Research assistant

    2004.4 - 2019.3

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  • Faculty of dentistry, Kyushu university hospital   Dept.of oral & maxillofacial radiology,   Research Assistant

    1997.4 - 2004.3

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Professional Memberships

Committee Memberships

  • 日本歯科放射線学会   代議員  

    2019.4   

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    Committee type：Academic society

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  • 日本歯科放射線学会   和文誌編集委員  

    2014.4   

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    Committee type：Academic society

    日本口腔腫瘍学会

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Papers

  • Evaluation of CT Findings in Squamous and Non-Squamous Cell Carcinomas of the Maxillary Sinus Reviewed

    Yuka Asaumi, Mamiko Fujikura, Miki Hisatomi, Wlla E. Al-Hammad, Yohei Takeshita, Shunsuke Okada, Toshiyuki Kawazu, Yoshinobu Yanagi, Junichi Asaumi

    Journal of Hard Tissue Biology   34 ( 1 )   35 - 40   2025

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    Publishing type：Research paper (scientific journal)   Publisher：Society for Hard Tissue Regenerative Biology  

    DOI： 10.2485/jhtb.34.35

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  • Central dentinogenic ghost cell tumor of the maxilla: a case report with new imaging findings and review of the literature Reviewed

    Suzuka Yoshida, Yohei Takeshita, Toshiyuki Kawazu, Miki Hisatomi, Shunsuke Okada, Mamiko Fujikura, Kyoichi Obata, Kiyofumi Takabatake, Saori Yoshida, Junichi Asaumi

    Oral Radiology   40 ( 4 )   561 - 568   2024.7

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    A dentinogenic ghost cell tumor (DGCT) is a rare benign odontogenic tumor that commonly shows characteristics of solid proliferation and has a relatively high risk of recurrence after surgical treatment. We herein report a case of a central DGCT that occurred in the maxilla and resulted in bone expansion. This study highlights new imaging findings (particularly magnetic resonance imaging) along with histopathological observations. In addition, we conducted a review of the existing literature on this rare tumor. A 37-year-old man developed swelling around the right cheek. A benign odontogenic tumor such as ameloblastoma was suspected based on the imaging examination findings (including bone expansion and the internal characteristics of the tumor) on panoramic imaging, computed tomography, and magnetic resonance imaging. The lesion was surgically excised from the right maxilla. Postoperative histopathological examination led to a definitive diagnosis of central DGCT. The tumor comprised epithelial neoplastic islands, resembling ameloblastoma, inside tight fibroconnective tissue; masses of ghost cells and formation of dentin were also observed. We had suspected that the minute high-density region around the molars on the imaging examinations represented alveolar bone change; however, it represented dentin formation. This led to difficulty diagnosing the lesion. Although DGCT may present characteristic findings on imaging examinations, its occurrence is infrequent, and in some cases, the findings may include the presence or absence of an impacted tooth without obvious calcification. The present case suggests that we should consider the possibility of an odontogenic tumor with calcification when high-density structures are observed inside the lesion.

    DOI： 10.1007/s11282-024-00764-4

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    Other Link： https://link.springer.com/article/10.1007/s11282-024-00764-4/fulltext.html

  • Imaging characteristics of incidentally detected cosmetic surgery-derived foreign bodies on CT images in the maxillofacial region Reviewed

    Miki Hisatomi, Yohei Takeshita, Yoshinobu Yanagi, Shunsuke Okada, Mamiko Fujikura, Suzuka Yoshida, Toshiyuki Kawazu, Junichi Asaumi

    Oral Radiology   40 ( 2 )   277 - 284   2024.4

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s11282-023-00734-2

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  • Preliminary Study of Dental Caries Detection by Deep Neural Network Applying Domain-Specific Transfer Learning Reviewed

    Toshiyuki Kawazu, Yohei Takeshita, Mamiko Fujikura, Shunsuke Okada, Miki Hisatomi, Junichi Asaumi

    Journal of Medical and Biological Engineering   44   43 - 48   2024.2

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s40846-024-00848-w

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  • Radiological assessment of the dissection area in supraomohyoid neck dissection Reviewed

    Yohei Takeshita, Joe Iwanaga, Yoshio Ohyama, Soichiro Ibaragi, Yuki Matsushita, R. Shane Tubbs, Norio Kitagawa, Toshiyuki Kawazu, Miki Hisatomi, Shunsuke Okada, Mamiko Fujikura, Junichi Asaumi

    Surgical and Radiologic Anatomy   46   1643 - 1652   2024

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00276-024-03453-3

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  • Difficult Diagnosis of Osteosarcoma of the Mandible: ACase Report Comparing Pathology and Imaging Findings Reviewed

    Mamiko Fujikura, Toshiyuki Kawazu, Hotaka Kawai, Shunsuke Okada, Yoshinobu Yanagi, Junichi Asaumi

    The Journal of Okayama Dental Society   42 ( 2 )   45 - 54   2023.12

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (bulletin of university, research institution)  

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  • An imaging‑based diagnostic approach to vascular anomalies of the oral and maxillofacial region Reviewed

    Wlla Al‑Hammad, Mamiko Fujikura, Miki Hisatomi, Shunsuke Okada, Luciana Munhoz, Toshiyuki Kawazu, Yohei Takeshita, Mariko Fujita, Yoshinobu Yanagi, Jun-Ichi Asaumi

    Oncology Letters   26 ( 3 )   2023.7

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Spandidos Publications  

    DOI： 10.3892/ol.2023.13980

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  • 分化度が異なるOSCCにおけるCXCR4阻害剤の有用性

    吉田 沙織, 河合 穂高, 竹下 洋平, 岡田 俊輔, 藤倉 満美子, 久富 美紀, 河津 俊幸, 長塚 仁, 浅海 淳一, 柳 文修

    日本病理学会会誌   112 ( 1 )   290 - 290   2023.3

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    Language：Japanese   Publisher：(一社)日本病理学会  

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  • 分化度の異なる口腔扁平上皮癌におけるシスプラチンとCXCR4阻害剤併用の効果

    吉田 沙織, 河合 穂高, 竹下 洋平, 岡田 俊輔, 藤倉 満美子, 久富 美紀, 河津 俊幸, 長塚 仁, 浅海 淳一, 柳 文修

    日本口腔診断学会雑誌   36 ( 1 )   82 - 82   2023.2

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    Language：Japanese   Publisher：(一社)日本口腔診断学会  

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  • 分化度の異なる口腔扁平上皮癌におけるシスプラチンとCXCR4阻害剤併用の効果

    吉田 沙織, 河合 穂高, 竹下 洋平, 岡田 俊輔, 藤倉 満美子, 久富 美紀, 河津 俊幸, 長塚 仁, 浅海 淳一, 柳 文修

    日本口腔内科学会雑誌   28 ( 2 )   106 - 106   2022.12

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    Language：Japanese   Publisher：(一社)日本口腔内科学会  

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  • Ultrasound procedure for the diagnosis of mass lesions in the oral region. Reviewed

    Yohei Takeshita, Toshiyuki Kawazu, Miki Hisatomi, Shunsuke Okada, Mamiko Fujikura, Saori Yoshida, Yuri Namba, Yudai Shimizu, Yoshinobu Yanagi, Junichi Asaumi

    Oral radiology   2022.3

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    OBJECTIVES: To examine the diagnostic usefulness and procedures of ultrasonography (US) for mass lesions in the soft tissue of the oral region. METHODS: This study involved patients with mass lesions (tumorous lesions and cysts) who had undergone US and histopathological examinations from January 2017 to December 2019. The following points were evaluated by two observers using an evaluation scale: vascularity, echo intensity level, boundary, margin shape, distribution of internal echoes, and capsule. The usefulness of each point for differential diagnosis of tumorous lesions and cysts was statistically analyzed. RESULTS: Forty-five mass lesions in the soft tissue of the oral region (33 tumorous lesions and 12 cysts) were analyzed. There were significant differences in four evaluation points between the tumorous lesions and cysts: vascularity, echo intensity level, boundary, and margin shape. Cysts were almost completely excluded diagnostically, especially when vascularity was observed. There were also significant differences in two evaluation points between nonvascular tumorous lesions and cysts: echo intensity level and boundary. CONCLUSIONS: In US examination for mass lesions in the oral region, it was possible to diagnose tumorous lesions and exclude cysts when vascularity was observed. When vascularity was not observed, however, tumorous lesions and cysts could be identified using two evaluation points: echo intensity level and boundary.

    DOI： 10.1007/s11282-022-00605-2

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  • Influence of mesiodens on adjacent teeth and the timing of its safe removal. Reviewed International journal

    Majd Barham, Shunsuke Okada, Miki Hisatomi, Abdullah Khasawneh, Nouha Tekiki, Yohei Takeshita, Toshiyuki Kawazu, Mariko Fujita, Yoshinobu Yanagi, Junichi Asaumi

    Imaging science in dentistry   52 ( 1 )   67 - 74   2022.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    Purpose: To focus on the effects of the presence of mesiodens on adjacent teeth and to investigate the timing of its safe removal. Materials and Methods: Cone-beam computed tomography examinations, obtained at Okayama University Hospital over a three-year period, were inspected. Data were recorded including the number of mesiodens; associated abnormalities; and the relationship with neighboring structures. Depending on multiple factors, the risk of developing complications due to early extraction of a mesiodens was divided into three categories: high, medium, and low risk. Results: A total of 5,958 cone-beam computed tomography exams were obtained, 460 patients aged 3-85 years were diagnosed with a total of 568 mesiodens, 382 (67.3%) of which were discovered in young patients (age <10 years), and 333 (87.2%) of these were associated with abnormalities. Regarding the risk categories, 11 (1.9%) were considered to be in the high-risk, five (0.9%) in the medium-risk and 552 (97.2%) in the low-risk categories. Moreover, eight out of 11 high-risk mesiodens were extracted and no post-operative complications have been seen. Conclusion: As the results showed that no postoperative complications were seen in all the extracted cases of high-risk mesiodens, this indicates the possibility of safe extraction at an early age which could reduce related future complications.

    DOI： 10.5624/isd.20210218

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  • A Case of Odontogenic Myxoma of the Mandible with Expansion to the Alveolar Crest - Comparison of Imaging Findings and Pathological Findings: A Case Report Reviewed

    Saori Yoshida, Yohei Takeshita, Toshiyuki Kawazu, Tatsushi Matsumura, Junichi Asaumi, Hitoshi Nagatsuka, Yoshinobu Yanagi

    OPEN DENTISTRY JOURNAL   16   2022

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2174/18742106-v16-2202140

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  • Dynamic contrast-enhanced MRI as a predictor of programmed death ligand-1 expression in patients with oral squamous cell carcinoma Reviewed

    Nouha Tekiki, Mariko Fujita, Tatsuo Okui, Hotaka Kawai, May Oo, Toshiyuki Kawazu, Miki Hisatomi, Shunsuke Okada, Yohei Takeshita, Majd Barham, Hitoshi Nagatsuka, Yoshinobu Yanagi, Jun-Ichi Asaumi

    ONCOLOGY LETTERS   22 ( 5 )   2021.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3892/ol.2021.13039

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  • The potential for facial artery injury during mandibular third molar extraction. An anatomical study using contrast-enhanced computed tomography. Reviewed International journal

    Yohei Takeshita, Soichiro Ibaragi, Hirokazu Yutori, Jingo Kusukawa, R Shane Tubbs, Toshiyuki Kawazu, Junichi Asaumi, Joe Iwanaga

    Clinical anatomy (New York, N.Y.)   34 ( 8 )   1215 - 1223   2021.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    The purpose of this study was to evaluate the risk of injury to the facial (FA) and related arteries during mandibular third molar (MTM) extraction using contrast-enhanced computed tomography (CE-CT). CE-CT images of the MTM region were retrospectively reviewed. The area of the MTM was equally divided into three zones in the coronal images from mesial to distal, that is, zone 1, zone 2, and zone 3. The FA, submental artery (SMA), and sublingual artery (SLA) were identified. The distance from the mandible to FA, SMA, and SLA and the diameter of the FA, SMA, and SLA was measured in three zones, respectively. The thickness of the facial soft tissues and width of the mandible were measured at their maximum. The mean distance from the FA to the buccal cortical bone in zone 1, zone 2 and zone 3 was 2.24 mm, 2.39 mm and 1.67 mm, respectively. The SMA and SLA were found to be distal to the mandible. The mean diameter of the FA was 1.26 mm in males and 1.04 mm in females, respectively (p < 0.0001). The distance between the FA and buccal cortical bone of the mandible, and the patients' weight showed moderate correlation in zones 1 and 2. Based on our findings, the FA can be damaged if the surgical invasion reaches the facial soft tissues during MTM surgery. The patients' weight might be a good predictor for FA injury when CE-CT is not available.

    DOI： 10.1002/ca.23779

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  • 口腔腫瘤性病変への超音波検査の有用性の検討

    竹下 洋平, 河津 俊幸, 久富 美紀, 岡田 俊輔, 藤倉 満美子, 吉田 沙織, 難波 友里, 清水 雄大, 柳 文修, 浅海 淳一

    日本歯科医師会雑誌   74 ( 4 )   413 - 413   2021.7

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    Language：Japanese   Publisher：(公社)日本歯科医師会  

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  • 上顎正中過剰埋伏歯の抜歯適正時期の検討

    岡田 俊輔, Barham Majd, 久富 美紀, Khasawneh Abdullah, Tekiki Nouha, 竹下 洋平, 河津 俊幸, 藤田 麻里子, 柳 文修, 浅海 淳一

    日本歯科医師会雑誌   74 ( 4 )   411 - 411   2021.7

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  • 美容整形手術2年後に生じた注入剤を原因とする右側頬部膿瘍の1例

    久富 美紀, 河津 俊幸, 岡田 俊輔, 竹下 洋平, 藤田 麻里子, 藤倉 満美子, 吉田 沙織, 柳 文修, 浅海 淳一

    歯科放射線   61 ( 増刊 )   50 - 50   2021.5

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  • 口腔扁平上皮癌におけるシスプラチン-CXCR4阻害剤併用療法の有効性

    吉田 沙織, 河合 穂高, 長塚 仁, 竹下 洋平, 岡田 俊輔, 藤倉 満美子, 久富 美紀, 河津 俊幸, 浅海 淳一, 柳 文修

    日本病理学会会誌   110 ( 1 )   275 - 275   2021.3

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  • Assessment of Hounsfield unit in the differential diagnosis of odontogenic cysts. Reviewed International journal

    Kyonori Uehara, Miki Hisatomi, Luciana Munhoz, Toshiyuki Kawazu, Yoshinobu Yanagi, Shunsuke Okada, Yohei Takeshita, Emiko Arita Saito, Junichi Asaumi

    Dento maxillo facial radiology   50 ( 2 )   20200188 - 20200188   2021.2

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    OBJECTIVES: The purpose of this study was to evaluate the usefulness of Hounsfield unit (HU) assessment with multislice-CT in the differentiation of radicular cysts (RCs), dentigerous cysts (DCs) and odontogenic keratocysts (OKCs). METHODS: In total, 307 odontogenic cysts (RCs, DCs and OKCs) were included in this study. Cysts with lesion diameter <10 mm, cysts with artefacts affecting measurement of HU values, cysts involving infection and recurrent cysts were regarded as exclusion criteria. Images were acquired in three different types of CT scanners: Aquilion ONE, Discovery CT750 HD and SOMATOM Definition Flash. Differences in HU values among scanners and among types of odontogenic cysts were assessed using one-way analysis of variance; multiple comparisons were performed post hoc, using the Tukey-Kramer honestly significant difference test. RESULTS: In total, 164 cysts were analysed in this study (64 RCs, 57 DCs and 43 OKCs). Regardless of the type of lesion, the Aquilion ONE scanner demonstrated a significant difference in HU value, compared with the Discovery CT750 HD scanner. Regardless of CT scanner model, HU values significantly differed between DCs and OKCs (p < 0.0001), as well as between OKCs and RCs (p < 0.0001). CONCLUSIONS: HU values were found to vary among CT scanners and should always be associated with other lesion imaging features while interpreting and elaboration diagnostic hypothesis. Notably, the results suggested that OKCs might be able to be differentiated from DCs and RCs by using HU values.

    DOI： 10.1259/dmfr.20200188

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  • CT値を用いた歯原性嚢胞の鑑別の有用性と適応例の検討

    久富 美紀, 上原 京憲, 河津 俊幸, 岡田 俊輔, 竹下 洋平, 藤倉 満美子, 吉田 沙織, 藤田 麻里子, 柳 文修, 浅海 淳一

    岡山歯学会雑誌   39 ( 2 )   37 - 38   2020.12

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    Language：Japanese   Publisher：岡山歯学会  

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  • 転移学習を応用したディープ・ラーニングによる齲蝕画像診断の実験的研究

    河津 俊幸, 竹下 洋平, 岡田 俊輔, 久富 美紀, 浅海 淳一

    岡山歯学会雑誌   39 ( 2 )   39 - 39   2020.12

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  • Prediction of nodal metastasis based on intraoral sonographic findings of primary lesion in early-stage tongue cancer Reviewed

    Shintaro Kawano, Taichi Hattori, Yurie Mikami, Toru Chikui, Toshiyuki Kawazu, Taiki Sakamoto, Yasuyuki Maruse, Shoichi Tanaka, Eiki Hamada, Megumi Hiwatashi, Yurika Shiraishi, Kazunari Oobu, Tamotsu Kiyoshima, Seiji Nakamura

    International Journal of Oral and Maxillofacial Surgery   in print   2020.6

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  • Incidental findings in the thyroid gland on computed tomography images of the oral and maxillofacial region

    Abdullah Khasawneh, Yohei Takeshita, Miki Hisatomi, Toshiyuki Kawazu, Mariko Fujita, Shunsuke Okada, Yuri Namba, Yudai Shimizu, Yoshinobu Yanagi, Junichi Asaumi

    ONCOLOGY LETTERS   19 ( 3 )   2005 - 2010   2020.3

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    DOI： 10.3892/ol.2020.11298

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  • 鼻咽腔に発生した若年性血管線維腫3例の比較検討

    清水 雄大, 村上 純, 河津 俊幸, 久富 美紀, 藤田 麻里子, 竹下 洋平, 岡田 俊輔, 難波 友里, 柳 文修, 浅海 淳一

    歯科放射線   59 ( 増刊 )   57 - 57   2019.6

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  • 舌エコーの画像所見による潜在的頸部リンパ節転移の予測

    服部 多市, 川野 真太郎, 三上 友里恵, 筑井 徹, 河津 俊幸, 松原 良太, 後藤 雄一, 金子 直樹, 坂本 泰基, 橋口 有真, 神野 哲平, 丸瀬 靖之, 田中 翔一, 大部 一成, 中村 誠司

    日本口腔科学会雑誌   67 ( 2 )   200 - 201   2018.7

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  • Estimation of prognosis of tongue cancer using tumor depth and margin shape obtained from ultrasonography Reviewed

    Sitti Fadhillah Oemar Mattalitti, Toshiyuki Kawazu, Shintaro Kawano, Tatsuya Ikari, Hiroko Wada, Kazunori Yoshiura

    ORAL RADIOLOGY   33 ( 2 )   101 - 107   2017.5

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    DOI： 10.1007/s11282-016-0251-y

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  • 巨舌を呈した舌対称性脂肪腫症の1例 Reviewed

    見立 英史, 川野 真太郎, 清島 保, 三上 友里恵, 後藤 雄一, 河津 俊幸, 池邉 哲郎, 中村 誠司

    日本口腔腫瘍学会誌   28 ( 4 )   293 - 298   2016.12

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  • Dentigerous cysts with calcification mimicking odontogenic tumors: differential diagnosis by CT Reviewed

    Mayumi Shimizu, Dai Ogawa, Kazutoshi Okamura, Toshiyuki Kawazu, Toru Chikui, Kazunori Yoshiura

    ORAL RADIOLOGY   31 ( 1 )   14 - 22   2015.1

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    DOI： 10.1007/s11282-014-0173-5

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  • Carcinoma ex pleomorphic adenoma of the upper lip: a case of an unusual malignant component of squamous cell carcinoma. International journal

    Eiji Mitate, Shintaro Kawano, Tamotsu Kiyoshima, Toshiyuki Kawazu, Toru Chikui, Yuichi Goto, Ryota Matsubara, Seiji Nakamura

    World journal of surgical oncology   11   234 - 234   2013.9

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    BACKGROUND: Squamous cell carcinoma (SCC) as the malignant component of carcinoma ex pleomorphic adenoma (CXPA) occurring in upper lip is rare. CASE REPORT: A 55-year-old male patient presented with an asymptomatic mass of the upper lip that had noticed 8 years previously. The mass was clinically suspected to be a benign salivary gland tumor based on palpation and magnetic resonance imaging findings. A needle biopsy was then carried out, and the pathological diagnosis was pleomorphic adenoma. The tumor was removed under general anesthesia. Histopathological examination revealed well-demarcated tumor tissues showing typical histologic features of pleomorphic adenoma. However, SCC tissue with several mitotic figures was found in the central area of the tumor tissue. The tumor was finally diagnosed as CXPA. There was no evidence of recurrence or metastasis 6 years postoperatively. CONCLUSION: This is the first report of CXPA of the upper lip with an unusual malignant component of SCC.

    DOI： 10.1186/1477-7819-11-234

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  • Carcinoma ex pleomorphic adenoma of the upper lip: A case of an unusual malignant component of squamous cell carcinoma

    Eiji Mitate, Shintaro Kawano, Tamotsu Kiyoshima, Toshiyuki Kawazu, Toru Chikui, Yuichi Goto, Ryota Matsubara, Seiji Nakamura

    World Journal of Surgical Oncology   11   2013.9

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    DOI： 10.1186/1477-7819-11-234

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  • 下顎歯肉に見られた腺扁平上皮癌の1例

    見立 英史, 大部 一成, 吉賀 大午, 川野 真太郎, 河津 俊幸, 清島 保, 豊嶋 健史, 北村 亮二, 中村 誠司

    日本口腔腫瘍学会誌   24 ( 2 )   55 - 61   2012.6

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  • A new method for evaluating perceptible contrast information in digital intraoral radiographic systems Reviewed

    Kazutoshi Okamura, Kazunori Yoshiura, Masato Tatsumi, Toshiyuki Kawazu, Toru Chikui, Mayumi Shimizu, Tazuko K. Goto

    ORAL RADIOLOGY   27 ( 2 )   98 - 101   2011.12

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    DOI： 10.1007/s11282-011-0068-7

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  • Prediction and monitoring of the response to chemoradiotherapy in oral squamous cell carcinomas using a pharmacokinetic analysis based on the dynamic contrast-enhanced MR imaging findings Reviewed

    Toru Chikui, Shintaro Kawano, Toshiyuki Kawazu, Masamitsu Hatakenaka, Syouzou Koga, Masahiro Ohga, Yoshio Matsuo, Syunya Sunami, Tsuyoshi Sugiura, Yoshiyuki Shioyama, Makoto Obara, Kazunori Yoshiura

    EUROPEAN RADIOLOGY   21 ( 8 )   1699 - 1708   2011.8

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  • A case of osteoporotic bone marrow defect in the mandible

    OKA Shoji, KUBOTA Yasutaka, ISHIBASHI Hiroaki, KOBAYASHI Ieyoshi, KAWAZU Toshiyuki, SHIRASUNA Kanemitsu

    Journal of Oral Surgery Society of Japan   57 ( 5 )   264 - 268   2011.5

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    Osteoporotic bone marrow defect （OBMD） is a rare benign jaw lesion consisting of hematopoietic bone marrow, which results in a focal bone defect. The present report describes a case of OBMD in the mandibular molar region of a 53 year-old-woman. A panoramic radiograph showed the presence of an undefined round,thumb-sized radiolucent lesion in the lower left first molar region. The density inside of the lesion was −37.7 Hounsfield units on CT scanning, suggesting fat tissue. The biopsy specimens revealed fat tissue with thin bone trabeculae and hematopoietic cell infiltration. The clinical course has been uneventful without any treatment for 4 years.

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  • Imaging diagnosis of salivary gland tumor Invited Reviewed

    NAKAYAMA Eiji, OHUCHI Tomoyuki, KAKU Tohru, SHIBATA Takanori, ARISUE Makoto, NAGAYASU Hiroki, ABIKO Yoshihiro, UENO Mayumi, KAWAZU Toshiyuki, YOSHIURA Kazunori, ASAKA Yuichiro, UEDA Michihiro, YAMASHITA Tetsuro, NAKAMORI Kenji, HIRATSUKA Hiroyoshi, HARIYA Yasushi, SEKIGUCHI Takashi

    Journal of Japanese Society of Oral Oncology   23 ( 3 )   59 - 68   2011.1

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    The histopathological diagnosis of salivary gland tumors is sometimes difficult, because the tumors have various histologic patterns and manifold tissue components coexist in a histologic pattern. Therefore, the differential imaging diagnosis of a benign and malignant tumor in the salivary gland is also sometimes difficult.<br>A salivary gland lesion in which the border is slightly unclear is sometimes a malignant tumor, even though the borderline looks almost clear on the images. Therefore, in the imaging diagnosis of salivary gland tumors, the clearness of the boundary on the images is very important and its cautious interpretation is essential; the clearness should be judged not by CT but by ultrasonography and MRI. Moreover, the CT and MRI images should be observed by optimal indication on a DICOM Viewer, if possible.<br>Regarding major salivary gland tumors: over 70% of parotid gland tumors are benign, 40% of submandibular gland tumors are malignant, and 80% of sublingual tumors are malignant. These figures are important when interpreting diagnostic images of major salivary gland tumors. A parotid gland tumor in which the border is not always clear should be suspected as malignant. A lesion that is confirmed as a sublingual gland tumor on diagnostic images should be diagnosed as a malignant tumor.<br>Concerning minor salivary gland tumors: when the tumor is small, a borderline is often clear even though the tumor is malignant. Hence, imaging findings of a lesion with a clear boundary are not evidence of a benign tumor in the minor salivary gland. In malignant salivary gland tumors of the palatal region, particular attention should be paid to weak bone invasion, which cannot be detected on imaging findings. In the lip and buccal region, ultrasonography is the most effective imaging modality. It is necessary to remember that mucoepidermoid carcinoma occurs also in the jawbones.

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  • Effect of clenching on T2 and diffusion parameters of the masseter muscle. International journal

    Toru Chikui, Tomoko Shiraishi, Takahiro Ichihara, Toshiyuki Kawazu, Masamitsu Hatakenaka, Yukiko Kami, Kenji Yuasa, Kazunori Yoshiura

    Acta radiologica (Stockholm, Sweden : 1987)   51 ( 1 )   58 - 63   2010.2

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    BACKGROUND: Persistent muscle contractions during clenching are considered to be one reason for temporomandibular disorders. However, no report has evaluated the effect of clenching on the masticatory muscles, as measured by magnetic resonance imaging (MRI). PURPOSE: To investigate whether clenching has an effect on either T(2) or the coefficients for diffusion of the masseter muscles (MM), and to evaluate the effect of the distribution of bite force on such indices. MATERIAL AND METHODS: Twenty-three subjects were examined. Bite force was measured by a pressure-sensitive sheet, and the force of the right and the left sides was calculated. MRI was used to evaluate T(2), the apparent diffusion coefficient (ADC), and the primary (lambda(1)), secondary (lambda(2)), and tertiary eigenvalues (lambda(3)). These indices on the stronger side of the bite force were compared to those on the weaker side. Thereafter, the indices were compared between at rest and during clenching. RESULTS: There was no significant difference in any of the indices (T(2), ADC, lambda(1), lambda(2), and lambda(3)) between the side of stronger bite force and the side with weaker. T(2) increased by clenching, and the difference was significant in the side with stronger bite force (P = 0.006). ADC, lambda(1), lambda(2), and lambda(3) increased significantly by clenching (P <0.01, P <0.01, P <0.01, and P <0.01, respectively) on both sides. The percentage of change of lambda(2) by clenching was 26.2+/-15.7% on the stronger side and 26.9+/-18.6% on the weaker side, which was significantly greater than either that of lambda(1) or lambda(3). CONCLUSION: The coefficients for diffusion of the MM were sensitive to change by clenching, and lambda(2) was the most sensitive. Moreover, the relative distribution of the bite forces had no effect on any of the indices.

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  • A QUANTITATIVE ANALYSIS OF SONOGRAPHIC IMAGES OF THE SALIVARY GLAND: A COMPARISON BETWEEN SONOGRAPHIC AND SIALOGRAPHIC FINDINGS Reviewed

    Toru Chikui, Mayumi Shimizu, Toshiyuki Kawazu, Kazutoshi Okamura, Tomoko Shiraishi, Kazunori Yoshiura

    ULTRASOUND IN MEDICINE AND BIOLOGY   35 ( 8 )   1257 - 1264   2009.8

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  • 副耳下腺に生じた多形腺腫の1例 Reviewed

    見立 英史, 大部 一成, 笹栗 正明, 中村 典史, 川野 真太郎, 小林 家吉, 河津 俊幸, 中村 誠司

    日本口腔腫瘍学会誌   20 ( 4 )   291 - 296   2008.12

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  • 良性腫瘍(臨床) 当科における舌下腺腫瘍の臨床統計的検討

    梅津 健太郎, 川野 真太郎, 中尾 祐, 大部 一成, 中山 英二, 河津 俊幸, 小林 家吉, 清島 保, 中村 誠司

    日本口腔科学会雑誌   57 ( 1 )   120 - 120   2008.1

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  • 悪性リンパ腫と小唾液腺癌の画像診断 所見を読み取る 2.節外性悪性リンパ腫

    中山 英二, 岡村 和俊, 大山 順子, 川野 真太郎, 小林 家吉, 清島 保, 筑井 徹, 河津 俊幸, 吉浦 一紀, 中村 誠司, 白砂 兼光

    日本口腔腫瘍学会誌   19 ( 4 )   232 - 232   2007.12

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  • A newly developed interventional sialendoscope for a completely nonsurgical sialolithectomy using intracorpereal electrohydraulic lithotripsy Reviewed

    Eiji Nakayama, Kazutoshi Okamura, Takeshi Mitsuyasu, Toshiyuki Kawazu, Norifumi Nakamura, Seiji Nakamura, Kazunori Yoshiura

    JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY   65 ( 7 )   1402 - 1405   2007.7

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  • 体内電気水圧衝撃波を利用した非観血的内視鏡下唾石破砕摘出システムの開発

    中山 英二, 岡村 和俊, 光安 岳志, 河津 俊幸, 中村 典史, 中村 誠司, 吉浦 一紀

    日本口腔科学会雑誌   56 ( 1 )   186 - 186   2007.1

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  • 右側副耳下腺に生じた多形性腺腫の1例

    見立 英史, 大部 一成, 笹栗 正明, 中村 典史, 川野 真太郎, 小林 家吉, 河津 俊幸, 中村 誠司

    日本口腔腫瘍学会誌   18 ( 4 )   165 - 165   2006.12

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  • Long-term functional outcome of brachytherapy for carcinoma of the mobile tongue: focus on the atrophic change of irradiated tongue. International journal

    Yusuke Urashima, Katsumasa Nakamura, Yoshiyuki Shioyama, Tomonari Sasaki, Saiji Ohga, Takashi Toba, Naonobu Kunitake, Tooru Chikui, Toshiyuki Kawazu, Tomomi Yamada, Hiromi Terashima, Hiroshi Honda

    Japanese journal of clinical oncology   36 ( 11 )   681 - 7   2006.11

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    OBJECTIVE: To assess tongue atrophy and long-term functional outcome of mobile tongue cancer patients after interstitial radiotherapy. METHODS: Of 493 patients whose squamous cell carcinoma of the mobile tongue had been treated with low dose rate brachytherapy, there were 57 patients evaluated between July 2002 and April 2004 whose tongue had not been modified by surgical procedures and who had no primary recurrence. The median time from treatment to evaluation was 96 months (range: 9-214 months). Almost all of the patients belonged to the early stage tongue cancer (T1/T2/T3/T4=30:24:3:0), and all had received interstitial radiotherapy with a single-plane implant. To evaluate the deformity of the tongue, we used a grading system that classified the atrophic changes of the tongue into four categories (G0-G3). RESULTS: Thirty-nine patients (70%) showed mild tongue hemiatrophy (G1 or G2) in the irradiated side. However, no patients showed severe atrophy where the tongue cannot be made to protrude beyond the incisors (G3). The length of time after brachytherapy was >72 months and the age of the patients at brachytherapy had the same statistical significance (P=0.0366). As for functional outcome, understandability of speech and a normal diet were preserved for almost all patients. CONCLUSION: The progression of atrophic change in the irradiated tongue occurred over a long term after brachytherapy. However, most patients could maintain their activities of daily life without severe restriction.

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  • Patency assessment of the internal jugular vein after neck dissection

    T. Nagata, K. Matsunaga, T. Kawazu, S. Kawano, K. Oobu, M. Ohishi

    International Journal of Oral and Maxillofacial Surgery   35 ( 5 )   416 - 420   2006.5

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  • Correlation between diagnostic accuracy and perceptibility

    K Yoshiura, K Okamura, K Tokumori, E Nakayama, T Chikui, TK Goto, M Shimizu, T Kawazu

    DENTOMAXILLOFACIAL RADIOLOGY   34 ( 6 )   350 - 352   2005.11

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  • Effects of the automatic exposure compensation on the proximal caries diagnosis

    K Yoshiura, E Nakayama, M Shimizu, TK Goto, T Chikui, T Kawazu, K Okamura

    DENTOMAXILLOFACIAL RADIOLOGY   34 ( 3 )   140 - 144   2005.5

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  • コンピュータ診断支援(CAD)を利用した学生教育用教材の開発

    河津 俊幸, 徳森 謙二, 吉浦 一紀

    歯科放射線   45 ( 1 )   31 - 31   2005.3

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  • 当科における口腔扁平上皮癌頸部リンパ節転移の診断および治療方法の変遷と治療成績の向上

    中村 誠司, 蔵原 慎一, 筑井 徹, 河津 俊幸, 杉浦 剛, 豊嶋 健史, 林田 淳之將, 白砂 兼光

    日本口腔科学会雑誌   54 ( 1 )   84 - 85   2005.1

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  • Imaging and diagnostic accuracy of cervical lymph node metastasis with oral cancer

    KANDA Shigenobu, CHIKUI Toru, KAWAZU Toshiyuki, YUASA Kenji

    Journal of Japanese Society of Oral Oncology   16 ( 3 )   75 - 84   2004.9

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    Imag ineprocedures such as computed tomography (CT), ultrasonography (US) are examined for predicting cervical lymphnode metastasis in head and neck cancer patients. We reviewed the criteria for metastasis and diagnostic accuracy (sensitivity, specificity and accuracy) of these diagnostic procedures in previous reports. We then discussed the efficiency of these diagnostic procedures for predicting cervical metastasis. Furthermore, our criteria and its positive predict value (PPV) and negative predict value (NPV) with CT, B-mode US and power Doppler US, and the methods of CT and US examinations in our department werere ported.<BR>With CT, sensitivity and specificity were 49%-100%, 38%-100%, respectively. With B-mode US, sensitivity and specificity were 58%-95%, 37%-96%, respectively. With Doppler US, sensitivity and specificity were 55%-98%, 77%-100%, respectively. In the results of our study, PPV for predicting metastasis with CT was 91%. PPV for predicting metastasis with B-mode US were 97%. PPV for predicting metastasis with power Doppler US were 87%.

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  • Development of new sialendoscopy systems for endoscopic sialolithectomy and their clinical application

    NAKAYAMA Eiji, KAWAZU Toshiyuki, NAKAMURA Norifumi, OKAMURA Kazutoshi, KANDA Shigenobu, OHISHI Masamichi

    J.Jpn.Stomatol.Soc   53 ( 2 )   81 - 86   2004

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    We developed two types of fine sialendoscope, which could be introduced to the submandibular duct through the opening of sublingual caruncula. One is a sialendoscope of 1.1-mm outer-diameter (POLYDIAGNOST GmbH, Germany) with 6000-pixels optic fibers, and it has a working channel to insert a basket forceps and an irrigation channel. The other is a sialendoscope of 1.2-mm outer-diameter (FiberTech Co., Ltd., Japan) with 1600-pixels optic fibers and a working channel. Using these newly developed sialendoscopy systems and a 1.9F basket forceps (Boston Scientific Corporation, USA), we could successfully remove a sialolith of the submandibular gland of a 9-year-old girl.

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  • Interventional sialendoscopy: A new procedure for noninvasive insertion and a minimally invasive sialolithectomy Reviewed

    Eiji Nakayama, Kenji Yuasa, Mahiro Beppu, Toshiyuki Kawazu, Kazutoshi Okamura, Shigenobu Kanda

    Journal of Oral and Maxillofacial Surgery   61 ( 10 )   1233 - 1236   2003.10

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    DOI： 10.1016/S0278-2391(03)00691-8

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  • Computer-Assisted Diagnostic System Applied with ANFIS

    Tanaka Takemasa, Kawazu Toshiyuki, Kanda Shigenobu

    Journal of Biomedical Fuzzy Systems Association   5 ( 1 )   49 - 54   2003

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    Although some computer-assisted diagnostic systems have been reported recently, they have not been so much spread in clinical field yet. The principles of fuzzy or neural network are so complicated to the general clinicians and they do not have the skills or techniques, which are necessary to develop the computer-assisted diagnostic system. The authors herein propose the new method, which automatically optimize the system only by setting the simple inferences. Because the method can be utilized with an ordinary application on a standard personal computer, even the users who cannot make programs can develop the system. The method applies the adaptive neuro-fuzzy inference system (ANFIS), which is combined with fuzzy and neural network. In this method, membership functions, which are set temporally at first, can be optimized automatically by back propagation procedure of neural network. Consequently, the performance of the diagnostic system can be improved. The authors describes the outline of the method with the preliminary applied case to the ultrasonographic dignosis.

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  • The combined use of US and MR imaging for the diagnosis of masses in the parotid region

    TK Goto, K Yoshiura, E Nakayama, K Yuasa, O Tabata, T Nakano, T Kawazu, T Tanaka, K Miwa, M Shimizu, T Chikui, K Okamura, S Kanda

    ACTA RADIOLOGICA   42 ( 1 )   88 - 95   2001.1

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  • Computed tomography and ultrasonography of metastatic cervical lymph nodes in oral squamous cell carcinoma Reviewed

    K Yuasa, T Kawazu, T Nagata, S Kanda, M Ohishi, K Shirasuna

    DENTOMAXILLOFACIAL RADIOLOGY   29 ( 4 )   238 - 244   2000.7

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  • Medical Imaging of Cervical Lymph Node Metastasis in Patients With Oral Cancer.

    KANDA Shigenobu, YUASA Kenji, NAKAYAMA Eiji, KAWAZU Toshiyuki

    Shika Hoshasen   40 ( 2 )   109 - 121   2000

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    Palpation and imaging procedures such as computed tomography (CT), ultrasonography (US), magnetic resonance imaging (MR), radioisotope imaging (RI) and lymphography are examined for predicting cervical lymph node metastasis in head and neck cancer patients. We reviewed the criteria for metastasis and diagnostic accuracy (sensitivity, specificity and accuracy) of these diagnostic procedures in previous reports. We then discussed the efficiency of these diagnostic procedures for predicting cervical metastasis. Furthermore, our criteria and its positive predictive value (PPV) and negative predictive value (NPV) with CT, B-mode US and power Doppler US, and the methods of CT and US examinations in our department were reported. In previous reports, it was reported that sensitivity was 47%-97%, specificity was 38-92%, accuracy was 69-88% with palpation. The diagnostic efficiency of lympography was considered to be low. Now this procedure is not used in diagnosing cervical metastasis. 18FDG-PET was preformed mainly. Its sensitivity and specificity were 50-93% and 77-100%, respectively. With CT, sensitivity and specificity were 49%-100%, 38%-100%, respectively. With MR, sensitivity and specificity were 47%-100%, 48%-100%, respectively. With B-mode US, sensitivity and specificity were 58%-95%, 37%-96%, respectively. With Doppler US, sensitivity and specificity were 55%-98%, 77%-100%, respectively. In the results of our study, PPV for predicting metastasis with CT was 91%. PPV for predicting metastasis with B-mode US were 97%. PPV for predicting metastasis with power Doppler US were 87%.

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  • Clinical evaluation of "veraviewpocs" digital panoramic X-ray system.

    M. Tatsumi, K. Yoshiura, K. Yuasa, O. Tabata, E. Nakayama, T. Kawazu, T. Chikui, M. Katoh, S. Kanda

    International journal of computerized dentistry   3 ( 3 )   183 - 195   2000

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  • A new, simple method of making a spacer in interstitial brachytherapy for mobile tongue cancer Reviewed

    Kenji Yuasa, Toshiyuki Kawazu, Masahiro Morita, Satoru Uehara, Naonobu Kunitake, Shigenobu Kanda

    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics   89 ( 4 )   519 - 521   2000

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  • Sonography for the detection of cervical lymph node metastases among patients with tongue cancer: Criteria for early detection and assessment of follow-up examination intervals Reviewed

    Kenji Yuasa, Toshiyuki Kawazu, Naonobu Kunitake, Satoru Uehara, Junichi Omagari, Kazunori Yoshiura, Eiji Nakayama, Shigenobu Kanda

    American Journal of Neuroradiology   21 ( 6 )   1127 - 1132   2000

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  • Assessment of image quality in dental radiography, part 2 - Optimum exposure conditions for detection of small mass changes in 6 intraoral radiography systems Reviewed

    K Yoshiura, T Kawazu, T Chikui, M Tatsumi, K Tokumori, T Tanaka, S Kanda

    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS   87 ( 1 )   123 - 129   1999.1

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  • Assessment of image quality in dental radiography, part 1 - Phantom validity Reviewed

    K Yoshiura, T Kawazu, T Chikui, M Tatsumi, K Tokumori, T Tanaka, S Kanda

    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS   87 ( 1 )   115 - 122   1999.1

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  • Computer-assisted Diagnostic System for Ultrasonography Using Fuzzy Reasoning : -Consideration of Defuzzification Procedure-

    Tanaka Takemasa, Kawazu Toshiyuki, Kanda Shigenobu

    Journal of Biomedical Fuzzy Systems Association   1 ( 1 )   1 - 6   1999

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    The authors have developed a computer-assisted diagnostic system for ultrasonograpny using fuzzy reasoning. In this system, we adopted the centroid method of defuzzification for fuzzy reasoning. There have been reported, however, several methods for defuzzidication. Although the computer-assisted diagnosis obtained from fuzzy reasoning might varies with different defuzzification methods, there were few literatures concerning this subject. Hence, the authors considered other defuzzidcation methods;centroid(Cent), bisector(Bis), middle of maximum(MOM), largest of maximum(LOM)and smallest of maximum(SOM)methods. Diagnostic accuracy, sensivity and specificity acquired from these defuzzifications were compared each other. Consequently, Cent, Bis and MOM are adequate procedures. On the other hand, diagnostic accuracy acquired by LOM or SOM is worse than other procedures. However, sensitivity of LOM and specificity of SOM are better than others. Therefore, these methods are useful when sensitivity or specificity is clinically important.

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  • Consideration for Density Optimization and Dose Reduction of Digital Dental Imaging System Using Fuzzy C-Means Clustering

    Tanaka Takemasa, Kawazu Toshiyuki, Kanda Shigenobu

    International Journal of Biomedical Soft Computing and Human Sciences: the official journal of the Biomedical Fuzzy Systems Association   5 ( 1 )   33 - 38   1999

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    Recently the digital dental imaging system (DDIS) has been developed and its use has spread widely. Although it has several advantages, the image quality is not better than that of conventional dental radiographs. Particularly, the density distributions of DDIS images are often insufficient and inadequate. Therefore, the authors considered the density optimization of DDIS images. For this aim, we applied a fuzzy c-means clustering algorithm because the pattern of DDIS images has an extensive variety. Using our method, the denstity distribution of most DDIS images can be improved appropriately. In addition, this method provides a dose reduction for the patients. Consequently, 38.3% of the absorbed dose was decreased.

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  • Diagnostic accuracy of CT and US for cervical lymph node metastasis of oral cancer patients.

    Yuasa Kenji, Kawazu Toshiyuki, Kanda Shigenobu

    Journal of Japanese Society of Oral Oncology   10 ( 4 )   288 - 296   1998

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    Purpose: The purposes of this study were to show our protocol of diagnostic imaging using CT and ultrasonography and to evaluate the diagnostic accuracy for cervical lymph node metastasis in oral squamous cell carcinoma.<BR>Material and Methods: CT and/or ultrasonography of 147 patients were evaluated retrospectively. Lymph nodes were confirmed pathologically whether metastasis or non-metastasis. The detection ratio, enhanced pattern and short diameter of lymphadenopathy were analyzed on CT. Internal echoes such as hilus and parenchymal echoes, the short diameter, long diameter and the long to short diameter ratio (S/L ratio) were evaluated on ultrasonography.<BR>Results: Ten percent of lymphadenopathy, which was confirmed pathologically as metastasis, was not found on CT. Heterogeneous or rim-enhanced pattern was presented in 50.9% of metastasis and only 4.5% of non-metastasis cases on CT. Strong parenchymal echo pattern was shown in 56.9% of metastasis cases. On the other hand, 66.5% of non-metastasis cases showed a hilus but strong parenchymal echoes. Under the circumstances where lymph nodes had neither hilus nor strong parenchymal echoes, but were 10 mm or more in short diameter, 27.4% were shown in metastasis and only 3.0% in non-metastasis cases. Futhermore, under the circumstances where lymph nodes had neither hilus nor strong parenchymal echoes, but were 3.5 or more in S/L ratio, only 1.5% were shown in metastasis and 13.5% in non-metastasis cases.<BR>Conclusion: On basis of the results of this study, it was suggested that criteria for cervical metastasis using CT and ultrasonography in which"Questionable only on diagnostic imagings"be included. It was considered that this criteria is clinically useful.

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  • Imaging Diagnosis Between Benign Odontogenic Tumor And Cyst Using Neural Network

    Kawazu Toshiyuki, Tanaka Takemasa, Kanda Shigenobu

    Proceedings of the Annual Conference of Biomedical Fuzzy Systems Association   11   27 - 28   1998

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    Aim of this study is to consider the accuracy in differentiating between benign odontogenic tumor (ameloblastoma) and cyst (odontogenic keratocyst) on CT image using neural network. In order to determine the weights and the biases of our neural network system, 53 cases (29 ameloblastomas, and 24 odontogenic keratocysts) were used for the learning mode. Another 20 cases (6 ameloblastomas, and 14 odontogenic keratocysts) were evaluated for determining the accuracy in the test mode. The result showed that the diagnostic accuracy was 85 %. It was suggested that the neural network is useful for differentiating these lesions.

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  • Consideration for Density Optimization and Dose Reduction of Digital Dental Imaging System Using Fuzzy C-Means Clustering

    Tanaka Takemasa, Kawazu Toshiyuki, Kanda Shigenobu

    Proceedings of the Annual Conference of Biomedical Fuzzy Systems Association   11   29 - 30   1998

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    Recently the digital dental imaging system (DDIS) has been developed and spread widely. The density distribution of DDIS images, however, are insufficient or inadequate. Therefore, the authors considered the density optimization of DDIS images, and applied the fuzzy reasoning and fuzzy c-means clustering algorithm for this purpose. According to our method, density distribution of most DDIS images could be improved appropriately. Moreover, this method could be applied to the dose reduction of the patients. Consequently, it was suggested that the absorbed dose could be decreased 38.3%.

    DOI： 10.24466/pacbfsa.11.0_29

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  • Density Optimization for Digital Dental Imaging System Using Fuzzy Reasoning and C-Means Clustering

    Tanaka Takemasa, Kawazu Toshiyuki, Kanda Shigenobu

    Proceedings of the Annual Conference of Biomedical Fuzzy Systems Association   10   75 - 76   1997

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    The digital dental imaging system (DDIS) has been developed and spread widely in recent years. The images of DDIS, however, aren't always so good, because of insufficient density distribution. Therefore, it seems that DDIS requires density optimization in an appropriate way. The authors applied the fuzzy reasoning and fuzzy c-means clustering algorithm for this purpose. According to our method, density distribution of most DDIS images could be improved better than the conventional histogram equalization method.

    DOI： 10.24466/pacbfsa.10.0_75

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  • Morphologic analysis of odontogenic cysts with computed tomography Reviewed

    Kazunori Yoshiura, Yoshinori Higuchi, Kazuyuki Araki, Masanori Shinohara, Toshiyuki Kawazu, Kenji Yuasa, Osamu Tabata, Shigenobu Kanda

    Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics   83 ( 6 )   712 - 718   1997

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Mosby Inc.  

    DOI： 10.1016/S1079-2104(97)90325-5

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Books

  • 解説と例題でわかる 歯科放射線テキスト

    （ Role： Contributor ,  唾液腺）

    2021.1 

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  • 口腔・歯・顎・顔面ポケット画像解剖

    中山 英二, 森本 泰宏（CBCT、顎関節撮影）

    医学情報社  2019.2  （ ISBN:9784903553764 ）

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    Total pages：249p   Language：Japanese

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  • CT・MRIアトラス Update-正常解剖と読影のポイント

    （ Role： Contributor ,  頸部リンパ節）

    医学書院  2009.11 

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  • Computer-aided diagnosis of the jaw bone diseases

    Oral and Maxillofacial Radiology Today  2000 

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MISC

  • A case of multiple neurogenic tumors discovered with buccal mucosa schwannoma

    久富美紀, 竹下洋平, 河合穂高, 岡田俊輔, 藤倉満美子, 吉田沙織, 河津俊幸, 長塚仁, 柳文修, 柳文修, 浅海淳一, 浅海淳一

    日本口腔腫瘍学会総会・学術大会プログラム・抄録集   41st   2023

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  • 口腔顎顔面領域の臨床解剖と画像診断

    竹下洋平, 河津俊幸, 久富美紀, 岡田俊輔, 藤倉満美子, 伊原木聰一郎, 岩永譲, 岩永譲, 影山幾男, 松下祐樹, TUBBS R. Shane, 浅海淳一, 浅海淳一, 浅海淳一

    日本解剖学会総会・全国学術集会講演プログラム・抄録集   127th (CD-ROM)   2022

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  • 鼻咽腔に発生した若年性血管線維腫3例の比較検討

    清水雄大, 村上純, 河津俊幸, 久富美紀, 藤田麻里子, 竹下洋平, 岡田俊輔, 難波友里, 柳文修, 浅海淳一, 浅海淳一, 浅海淳一

    歯科放射線   59   2019

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  • 口腔扁平上皮癌術後の再発検出に対するTSE DWIの有用性

    筑井徹, WANNAKAMON Panyarak, 河津俊幸, 山下泰生, 武村濃, 吉浦一紀, 吉浦一紀

    歯科放射線   57   2017

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  • 下顎歯肉に認められた腺扁平上皮癌の1例

    見立英史, 大部一成, 吉賀大午, 河津俊幸, 小林家吉, 川野真太郎, 中村誠司

    日本口腔腫瘍学会総会・学術大会プログラム・抄録集   28th   2010

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  • Sonographic diagnosis for Mikulicz disease

    Mayumi Shimizu, Masafumi Moriyama, Kazutoshi Okamura, Toshiyuki Kawazu, Toru Chikui, Tazuko K. Goto, Yukiko Ohyama, Seiji Nakamura, Kazunori Yoshiura

    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY   108 ( 1 )   105 - 113   2009.7

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  • Treatment of early tongue carcinoma with brachytherapy: Results over a 25-year period

    Yusuke Urashima, Katsumasa Nakamura, Yoshiyuki Shioyama, Satoru Nomoto, Sair Ohga, Takashi Toba, Tadamasa Yoshitake, Toru Chikui, Toshiyuki Kawazu, Kenichi Jingu, Hiromi Terashima, Hiroshi Honda

    ANTICANCER RESEARCH   27 ( 5B )   3519 - 3523   2007.9

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  • Is glossectomy necessary for late nodal metastases without clinical local recurrence after initial brachytherapy for N0 tongue cancer? A retrospective experience in 111 patients who received salvage therapy for cervical failure

    Y Urashima, K Nakamura, N Kunitake, Y Shioyama, T Sasaki, S Ooga, Y Kuratomi, T Yamamoto, T Kawazu, T Chikui, K Jingu, H Terashima, H Honda

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   36 ( 1 )   3 - 6   2006.1

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  • Intraoral sonographic features of tongue cancer after radical radiotherapy

    Toru Chikui, Toshiyuki Kawazu, Katsumasa Nakamura, Yuusuke Urashima, Kenji Yuasa, Shigenobu Kanda

    European Journal of Radiology   52 ( 3 )   246 - 256   2004.12

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    Language：English   Publishing type：Book review, literature introduction, etc.  

    DOI： 10.1016/j.ejrad.2004.01.012

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  • Quantitative analysis of radiological changes in alveolar bone around connected osseo-integrated dental implants and natural abutment teeth

    TAKASHIMA Akihiro, YOSHIURA Kazunori, TOKUMORI Kenji, KAWAZU Toshiyuki, KANDA Shigenobu

    19 ( 1 )   28 - 37   2003.6

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  • Analysis of different approaches to constructing perceptibility curves

    YOSHIURA Kazunori, WELANDER Ulf, LI Gang, SHI Xie-Qi, MCDAVID William D., KAWAZU Toshiyuki, TATSUMI Masato, OKAMURA Kazutoshi, KANDA Shigenobu

    Oral Radiol   19 ( 1 )   38 - 48   2003.6

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  • Perceptibility curves for the Digora system

    K Yoshiura, U Welander, WD McDavid, G Li, XQ Shi, T Kawazu, M Tatsumi, T Matsuo, S Kanda

    DENTOMAXILLOFACIAL RADIOLOGY   32 ( 3 )   191 - 197   2003.5

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  • Value of computed tomography findings in differentiating between intraosseous malignant tumors and osteomyelitis of the mandible affecting the masticator space Reviewed

    Y Hariya, K Yuasa, E Nakayama, T Kawazu, K Okamura, S Kanda

    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS   95 ( 4 )   503 - 509   2003.4

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    Language：English   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

    DOI： 10.1067/moe.2003.134

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  • Application of Neural Networks to the Prediction of Lymph node Metastasis in Oral Cancer Reviewed

    Toshiyuki Kawazu, Kazuyuki Araki, Kazunori Yoshiura, Eiji Nakayama, Shigenobu Kanda

    Oral Radiology   19 ( 2 )   137 - 142   2003.4

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    Authorship：Lead author   Language：English  

    DOI： 10.1007/BF02493239

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  • Diagnostic accuracy of CT in detecting the extent of tumor invasion into the surrounding soft tissue by squamous cell carcinoma of the mandibular gingiva

    NAKAYAMA Eiji, YUASA Kenji, TABATA Osamu, KAWAZU Toshiyuki, CHIKUI Toru, KANDA Shigenobu, NAKAMURA Seiji, YOSHIKAWA Hiromasa, OOBU Kazunari, IKEBE Tetsuro, OHISHI Masamichi, SHIRASUNA Kanemitsu

    Journal of Japanese Society of Oral Oncology   13 ( 4 )   253 - 256   2001.12

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    Objective: To clarify the diagnostic accuracy of CT in detecting the extent of tumor invasion into the surrounding soft tissues by squamous cell carcinoma of the mandibular gingiva.<BR>Method: Axial CT scans of 77 patients with carcinoma of the mandibular gingiva were evaluated by three Oral and maxillof acial radiologists for the tumor invasion into the surrounding soft tissues. All patients underwent excision of the tumor in Kyushu University Dental Hospital from 1992 to 1999, and the presence and the extent of tumor invasion were confirmed by the macroscopic or histopahological findings following surgery. The observers rated their level of confidence for the presence of tumor invasion into genioglossus muscle (GGM), mylohyoid muscle (MHM), intrinsic lingual muscles (ILM), internal pterygoid muscle (IPM), masseter muscle (MM), labiobuccal tissues (LBT), and platysma muscle (PM) on the following five-point scale : 1, negative ; 2, probably negative ; 3, unsure ; 4, probably positive; 5, positive. The mean ROC curve area (Az) of each observer for tumor invasion into each tissue was obtained, and used as the index of diagnostic accuracy.<BR>Results : The mean Az values for the detection of tumor invasion on CT was 0.86 for GGM and IPM, 0.82 for MHM, 0.80 for MM, 0.76 for ILM, 0.71 for LBT, and 0.65 for PM.<BR>Conclusion : We should carefully interpret the tumor invasion into ILM, LBT and PM on CT images referring to the various clinical information, including inspection or palpation.

    DOI： 10.5843/jsot.13.Suppliment_253

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  • DIAGNOSIS OF CERVICAL LYMPH NODE METASTASIS USING POWER DOPPLER ULTRASONOGRAPHY

    YUASA Kenji, CHIKUI Toru, KAWAZU Toshiyuki, NAKANO Toshiaki, KUNITAKE Naonobu, NAKAMURA Katsumasa, KANDA Shigenobu

    27 ( 3 )   727 - 731   2001.11

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  • Effects of the automatic exposure compensation on the proximal caries diagnosis

    YOSHIURA K, KAWAZU T, TATSUMI M, NAKAYAMA E, SHIMIZU M, GOTO TK, CHIKUI T, OKAMURA K, KANDA S

    41   24 - 24   2001.9

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  • Computer-Aided Diagnosis for cervical lymph node metastasis

    KAWAZU T, ARAKI K, YUASA K, YOSHIURA K, KANDA S

    41   45 - 45   2001.9

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  • Newly Contrived Computer-aided Diagnostic System Using Fuzzy Inference Combined with Neural Network Algorism : An Attempt to the Sonographic Diagnosis

    TANAKA T, KAWAZU T, KANDA S

    41   79 - 79   2001.9

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  • Conventional and predicted Perceptibility Curves for contrast-enhanced direct digital intraoral radiographs

    K Yoshiura, U Welander, XQ Shi, G Li, T Kawazu, M Tatsumi, K Okamura, WD McDavid, S Kanda

    DENTOMAXILLOFACIAL RADIOLOGY   30 ( 4 )   219 - 225   2001.7

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  • 超音波パワードプラ法を用いたリンパ節内血流像による診断

    湯浅 賢治, 筑井 徹, 河津 俊幸, 中野 敏昭, 國武 直信, 中村 和正, 神田 重信

    頭頚部腫瘍   27 ( 2 )   326 - 326   2001.5

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  • 口腔顎顔面領域のInterventional Radiology 各種のIVRとその有効性

    中山 英二, 湯浅 賢治, 河津 俊幸

    映像情報medical   33 ( 1 )   63 - 69   2001.1

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    Other Link： http://search.jamas.or.jp/link/ui/2001123650

  • CT and US findings of cervical lymph node in each location

    YUASA K, KAWAZU T, CHIKUI T, KANDA S

    40   68 - 68   2000.10

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  • Number of cervical lymph node

    YUASA K, KAWAZU T, CHIKUI T, KANDA S

    40   85 - 85   2000.10

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  • Clinical evaluation of high-speed digital panoramic X-ray system

    TATSUMI M, YOSHIURA K, CHIKUI T, NAKAYAMA E, YUASA K, KAWAZU T, GOTO T, KATO M, KANDA S

    40   33 - 33   2000.10

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  • ニューラルネットワークの画像診断への応用

    日本医用画像工学会   18(5), 698-702   2000

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  • Development and accuracy of imaging diagnoses for lymph node metastasis with oral cancer

    KANDA S, YUASA K, NAKAYAMA E, KAWAZU T, MAEMURA S, ONIZUKA S

    39   67 - 67   1999.10

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  • US of the masses in parotid region

    GOTO T, YOSHIURA K, NAKAYAMA E, YUASA K, TABATA O, NAKANO T, KAWADU T, TANAKA T, MIWA K, SHIMIZU M, CHIKUI T, OKAMURA K, KANDA S

    39   99 - 99   1999.10

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  • Perceptibility curves of direct digital intraoral radiographic systems : Effects of the contrast enhancement

    YOSHIURA K, KAWAZU T, CHIKUI T, KANDA S, WELANDER Ulf

    39   117 - 117   1999.10

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  • MR imaging of the masses in parotid region

    GOTO T, YOSHIURA K, NAKAYAMA E, YUASA K, TABATA O, NAKANO T, KAWADU T, TANAKA T, MIWA K, SHIMIZU M, CHIKUI T, OKAMURA K, KANDA S

    39   100 - 100   1999.10

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  • Value of contrast-enhanced magnetic resonance imaging in differentiation of hemangiomas front lymphangiomas in the oral and maxillofacial region Reviewed

    K Yonetsu, E Nakayama, T Kawazu, S Kanda, S Ozeki, M Shinohara

    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS   88 ( 4 )   496 - 500   1999.10

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  • ニューラルネットワークによる頸部リンパ節転移診断支援の有効性の検討 ROC曲線をもちいた支援効果の検討

    荒木 和之, 三輪 邦弘, 花澤 智美, 松田 幸子, 山本 実佳, 田谷 あつ子, 河津 俊幸, 岡野 友宏

    歯科放射線   39 ( 3 )   179 - 180   1999.9

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  • Physical evaluation of a system for direct digital intra-oral radiography based on a charge-coupled device

    K Yoshiura, HC Stamatakis, U Welander, WD McDavid, XQ Shi, S Ban, T Kawazu, M Tatsumi, S Kanda

    DENTOMAXILLOFACIAL RADIOLOGY   28 ( 5 )   277 - 283   1999.9

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  • Prediction of Perceptibility Curves of direct digital intraoral radiographic systems

    K Yoshiura, HC Stamatakis, U Welander, WD McDavid, XQ Shi, S Ban, T Kawazu, T Chikui, S Kanda

    DENTOMAXILLOFACIAL RADIOLOGY   28 ( 4 )   224 - 231   1999.7

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  • シリーズ・顎・顔面領域における最新の超音波診断法--頸部リンパ節転移に対する超音波診断

    湯浅 賢治, 河津 俊幸, 中野 敏昭

    映像情報   31 ( 8 )   463 - 466   1999.4

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  • The change of CT and US findings of cervical lymphadenopathy in oral squamous cell carcinoma before and after preoperative chemoradiotherapy

    Toshiyuki Kawazu, Kenji Yuasa, Shigenobu Kanda, Satoru Ozeki, Masanori Shinohara

    Japan Society for Oral Tumors   11 ( 3 )   135 - 142   1999

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  • The change of CT and US findings of cervical lymphadenopathy in oral squamous cell carcinoma before and after preoperative chemoradiotherapy

    KAWAZU Toshiyuki, YUASA Kenji, KANDA Shigenobu, OZEKI Satoru, SHINOHARA Masanori

    11 ( 3 )   135 - 142   1999

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  • ニューラルネットワークによるエナメル上皮腫と歯原性角化嚢胞の画像診断への応用

    河津 俊幸, 荒木 和之, 吉浦 一紀, 大関 悟, 篠原 正徳, 神田 重信

    日本口腔科学会雑誌   47 ( 5 )   661 - 661   1998.12

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  • エナメル上皮腫と歯原性角化嚢胞の画像診断学的特徴 CT-axial像の皮質骨所見

    河津 俊幸, 吉浦 一紀, 荒木 和之, 神田 重信

    歯科放射線   38 ( 増刊 )   57 - 57   1998.9

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  • Mucoepidermoid carcinoma in the mandible - Findings of panoramic radiography and computed tomography

    M Inagaki, K Yuasa, E Nakayama, T Kawazu, T Chikui, S Kanda, H Yoshikawa, S Nakamura, M Shinohara

    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS   85 ( 5 )   613 - 618   1998.5

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  • Submandibular gland duct endoscopy - Diagnostic value for salivary duct disorders in comparison to conventional radiography, sialography, and ultrasonography. Reviewed

    K Yuasa, E Nakhyama, SG Ban, T Kawazu, T Chikui, M Shimizu, S Kanda

    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS   84 ( 5 )   578 - 581   1997.11

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  • Differential diagnosis between Ameloblastoma and Odontogenic keratocyst using Neural Network

    KAWAZU Toshiyuki, ARAKI Kazuyuki, YOSHIURA Kazunori, KANDA Shigenobu

    37   96 - 96   1997.9

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  • Dopplar ultrasonography of cervical lymph nodes : Change of findings depending on velocity scale

    YUASA K., MIWA K., KAWAZU T., SHIMIZU M., NAKANO T., KAGE W., KANDA S.

    37   90 - 90   1997.9

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  • Differential Diagnosis between Ameloblastoma and Odontogenic Keratocyst using Computed Tomography

    KAWAZU Toshiyuki, ARAKI Kazuyuki, YOSHIURA Kazunori, YUASA Kenji, KANDA Shigenobu, HIGUCHI Yoshinori, OHZEKI Satoru, SHINOHARA Masanori

    37 ( 3 )   211 - 218   1997

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  • Differential Diagnosis between Ameloblastoma and Odontogenic Keratocyst using Computed Tomography

    Toshiyuki KAWAZU, Kazuyuki ARAKI, Kazunori YOSHIURA, Kenji YUASA, Shigenobu KANDA, Yoshinori HIGUCHI, Satoru OHZEKI, Masanori SHINOHARA

    Dental Radiology   37 ( 3 )   211 - 218   1997

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  • Study on the Computer-Assisted Image Diagnosis Using Neural Network : Diagnosis of the swelling at the parotid region

    ARAKI Kazuyuki, YUASA Kenji, MIWA Kunihiro, YOSHIURA Kazunori, KAWAZU Toshiyuki, KANDA Shigenobu

    36   41 - 41   1996.9

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  • Construction of An Internet Film Conference System

    TOKUMORI Kenji, YUASA Kenji, TANAKA Takemasa, KAWAZU Toshiyuki, KANDA Shigenobu, TOYOFUKU Fukai

    36   128 - 128   1996.9

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  • Imaging Diagnosis for Mass lesions of the Buccomasseteric region

    YONETSU Koichi, YUASA Kenji, YOSHIURA Kazunori, CHIKUI Tohru, KAWAZU Toshiyuki, KANDA Shigenobu

    36   119 - 119   1996.9

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  • Cervical lymph nodes in oral cancer : CT and US findings

    YUASA K., KAWAZU T., NAGATA T., MIWA K., YOSHIURA K., TABATA O., NAKAYAMA E., SHIMIZU M., BAN S., ARAKI K., CHIKUI T., GOTO T., INAGAKI M., KANDA S., SHINOHARA M., OZEKI S.

    36   58 - 58   1996.9

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  • Diagnostic accuracy of CT and US for cervical lymph node metastasis

    KAWAZU T., YUASA K., NAGATA T., MIWA K., YOSHIURA K., TABATA O., NAKAYAMA E., SHIMIZU M., BAN S., ARAKI K., CHIKUI T., GOTO T., INAGAKI M., KANDA S., SHINOHARA M., OZEKI S.

    36   59 - 59   1996.9

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Presentations

  • 舌腫瘍における超音波エラストグラフィの診断的有用性の検討

    中村吉秀, 河津俊幸, 竹下洋平, 岡田俊輔, 藤倉満美子, 久富美紀, 飯田征二, 伊原木聰一郎, 柳文修

    日本歯科放射線学会第65回学術大会  2025.5.30 

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  • 咀嚼筋間隙に発生し特異な石灰化を呈した腫瘍性病変の１例

    河津俊幸, 竹下洋平, 藤倉満美子, 岡田俊輔, 久富美紀, 吉田沙織, 中野敬介, 柳 文修

    第43回関西・九州合同地方会（第66回関西・第62回九州地方会）  2025.2.8 

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  • Preliminary study for classifying dental caries using deep neural network with transfer-learning

    Toshiyuki Kawazu, Yohei Takeshita, Mamiko Fujikura, Shunsuke Okada, Miki Hisatomi, Junichi Asaumi

    The 13th Asian Congress of Oral and Maxillo-Facial Radiology  2022.6.3 

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  • MRI Findings of Odontogenic tumor and cyst

    2020.12.5 

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Research Projects

  • A Multicenter Study for the Introduction of Ultrasonography into the Diagnostic Criteria of IgG4-Related Dacryoadenitis and Sialadenitis

    Grant number：21K10075  2021.04 - 2024.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    清水 真弓, 岡村 和俊, 森山 雅文, 大山 順子, 徳森 謙二, 荒木 和之, 河津 俊幸, 木瀬 祥貴, 高木 幸則, 筑井 朋子, 林 孝文

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    Grant amount：\4290000 （ Direct expense: \3300000 、 Indirect expense：\990000 ）

    我々はIgG4 関連疾患のひとつである両側涙腺・顎下腺の腫脹を主徴候とするIgG4関連涙腺・唾液腺炎（ IgG4関連ミクリッツ病, IgG4-DS）でその顎下腺に特徴的な超音波像が認められること、血清IgG4値に顎下腺超音波検査を加えると高い正診率が得られることなどを報告してきた。IgG4-DSに特徴的な顎下腺超音波像はシェーグレン症候群の微細な像と異なり、比較的容易に検出される像ではあるが、この項目をIgG4-DSの診断基準の1項目として採用するには、1.診断者の標準化の必要性の有無、2.エラストグラフィによる診断の簡便化の成否、3.AI診断の導入による診断の簡便化の成否、4.パワードプラ法での血流の多寡による予後判定の成否 の更なる検討が必要であると考える。
    本研究では顎下腺超音波検査に精通した歯科放射線科中心の多施設で上記4点について検討し、顎下腺超音波診断の正診率をより一層向上させ、本邦のみならず、国際的なIgG4-DSの診断基準に非侵襲的な顎下腺超音波検査を導入する基盤を確立することを目的としている。
    令和3年度は圧力センサの開発に着手した。エラストグラフィの画像や計測値は加えた圧力によって変化することが知られている。本研究では撮像時に圧力センサを用いることで、画像撮像時にかかる圧力を一定の範囲にすることを試みる。表在臓器のエラストグラフィ撮影時においては予想以上に力をかけられない事がわかり、バネ定数の小さなものを使用し、小さな圧力を測定する装置の開発を試みた。

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  • Application of Amide proton transfer imaging to the orofacial region

    Grant number：15K11073  2015.04 - 2019.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Toru Chikui

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    Grant amount：\4030000 （ Direct expense: \3100000 、 Indirect expense：\930000 ）

    We applied amide proton transfer imaging (APT imaging) to the orofacial region. Subsequently, we compared the parameter by APT image (MTR asymmetry) and the parameters obtained by the diffusion-weighted image. The MTR asymmetry of the malignant tumors was likely to be higher than those of the benign tumors, however, there were some overlap between them. Both in squamous cell carcinoma and malignant lymphoma, there was positive correlation between MR asymmetry and the apparent diffusion coefficient (ADC), which suggest the MR asymmetry reflect the production of ATP in the cell. However, such tendency was not found in the benign tumor.

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  • Establishment of non-invasive image diagnosis of Sjogren's syndrome using near-infrared spectrometer, MRI and sonography

    Grant number：24592835  2012.04 - 2015.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    YOSHINO (SHIMIZU) Mayumi, KAWAZU Toshiyuki, OKAMURA Kazutoshi, OHYAMA Yukiko, MORIYAMA Masafumi, ABE Koichiro, BABA Shingo

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    Grant amount：\5330000 （ Direct expense: \4100000 、 Indirect expense：\1230000 ）

    We performed an experimental study for establishing non-invasive image diagnosis of Sjogren’s syndrome (SS). The tendency of an elevation of oxy-hemoglobin after acid stimulation was observed using near-infrared spectrometer in the parotid glands. However, it did not correlate with the degree of gland damage. Moreover, we could not obtain similar results even in the same patients. Motion sensitized driven equilibrium (MSDE) method on MRI could not offer better images. Dynamic curve analysis on the conventional salivary gland scintigraphy showed significant differences between SS and non-SS in every calculated value in the submandibular glands. Therefore, diagnostic criteria on salivary gland scintigraphy should be established based on the values in the submandibular glands.

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  • The evaluation of head and neck lesions using permeability and perfusion MRI

    Grant number：24592834  2012.04 - 2015.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    CHIKUI Toru, TOKUMORI Kenji, KAWAZU Toshiyuki, YOSHIURA Takashi, HIWATASHI Akio, KAMI Yukiko, KAWANO Shintarou, YOSHIURA Kazunori

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    Grant amount：\4420000 （ Direct expense: \3400000 、 Indirect expense：\1020000 ）

    We performed compartment model analysis on the basis of the DCE-MRI. The arterial input function was estimated using phase images. We obtained the influx forward volume transfer constant (Ktrans), the fractional volume of extravascular extracellular space (ve) and the fractional volume of plasma (vp).The pleomorphic adenoma had lower Ktrans than malignant tumors. The ve was characteristic parameters among the tumors. Pleomorphic adenoma has a characteristic large ve value, while malignant lymphoma has characteristically small ve. In the oral squamous cell carcinoma, a decrease in the Ktrans at the primary site was found in advanced N stage cases, which might indicate that the hypoxic status cause a high possibility of the metastasis.
    For the evaluation of arterial spin labeling, we estimated the relative blood flow (r BF). There was significant correlation between r BF and Ktrans and between r BF and Ktrans. However, some lesions could not identified on r BF map.

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  • Sonographic sialography-trial for a new diagnostic method for salivary gland diseases

    Grant number：21592390  2009 - 2011

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    YOSHINO Mayumi, KAWAZU Toshiyuki, OKAMURA Kazutoshi

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    Grant amount：\4420000 （ Direct expense: \3400000 、 Indirect expense：\1020000 ）

    We performed an experimental study for“sonographic sialography", sonography after injecting sonographic contrast medium through ducts. Sonazoid was acceptable in manipulation capability and osmotic pressure, and caused no inflammatory reaction to rat parotid glands. We could obtain enough signals of contrast medium in our phantom experiments. Supposed problems when it is applied in a clinical setting are difficulty in measuring duct diameter by enhancing effect, and inferior depiction of deeper parts when the imposed parts above are enhanced.

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  • The evaluation of the effect of the occlusion on the masticatory muscle using H-MRI and P-MRS.

    Grant number：21592389  2009 - 2011

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    CHIKUI Toru, OKAMURA Kazutoshi, KAWAZU Toshiyuki, T0KUM0RI Ken. ji, YOSHIURA Kazunori

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    Grant amount：\4160000 （ Direct expense: \3200000 、 Indirect expense：\960000 ）

    We evaluated the effects of various task like jaw opening, jaw closure and tooth contact on the masseter muscle by using both MRI and MRS. The eigenvalues of the diffusion tenser were affected by the jaw position. Moreover, recruitment of the specific muscle fibers within the masseter muscle was reflected in differing changes at the different position. The T 2 of the masseter muscle was expected to decrease with contraction because the increased intramuscular pressure caused the decrease of per fusion and to increase rapidly after the contraction, because of the reactive hyperemia. After the rapid increase, it decreased gradually. Finally, we evaluated the Pi/PCr ratio, which was indicative of the concentration of ADP by using 31P-MRS. It increase during tooth contact, however, it decrease immediately after tooth contact, and after 5 minutes, it declined to the same level as at rest.

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  • Experimental study of the non-surgical sialendoscopic sialolithectomy using holmium YAG laser

    Grant number：19592301  2007 - 2008

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    AKAYAMA Eiji, KAWAZU Toshiyuki, OKAMURA Kazutoshi, NAKAMURA Seiji, SASAKI Masanori, TOKUMORI Kenji, GOTO Tazuko, YOSHIURA Kazunori, KAWAZU Toshiyuki, OKAMURA Kazutoshi, NAKAMURA Seiji, SASAKI Masanori, TOKUMORI Kenji, GOTO Tazuko, YOSHIURA Kazunori

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    Grant amount：\4550000 （ Direct expense: \3500000 、 Indirect expense：\1050000 ）

    唾液腺造影検査を行い、かつ手術により摘出された唾石を収集した。そのために唾液腺カテーテルを購入した。さらに唾石の微細構造を把握するために走査型電子顕微鏡で観察した。唾石は板状で結晶構造が密なものと、疎で球状、桿状の微生物様構造が優位なものの2種類が観察された。一方、ホルミウム・ヤグレーザー照射実験は環境整備が整わなかった。それまでの成果を第62回日本口腔科学会学術集会(2008年4月)で発表した。

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  • Real-time Tissue Elastography of masseter muscle

    2007

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    Grant type：Competitive

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  • エラストグラフィを利用した咬筋内部性状の評価

    2007

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    Grant type：Competitive

    エラストグラフィを用いて咬筋の弾性評価を行う

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  • Attempt for kinetic analysis in head and neck region using enhanced MRI

    Grant number：18592063  2006 - 2008

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    YOSHIURA Kazunori, CHIKUI Toru, TOKUMORI Kenji, SHIMIZU Mayumi, GOTO Tazuko, KAWAZU Toshiyuki, OKAMURA Kazutoshi

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    Grant amount：\3780000 （ Direct expense: \3300000 、 Indirect expense：\480000 ）

    良悪性の鑑別にMRIの造影パターンを判断材料にする事が多いが、信号強度自体は撮像法により異なり、各施設で共通した指標とはなりにくい。そのため信号強度自体を解析するのではなく、信号強度から造影剤濃度を算出し、薬物動態解析(コンパートモデル解析の一種であるTofts-Kermode model (TK model)を適応)することによって、組織固有のパラメーターを算出を試みた。その為には、造影剤投与後の造影剤濃度の把握が必要であり、算出方法の確立を行った。

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  • Interventional Radiology of salivary Gland Disease using balloon Catheter

    Grant number：17592090  2005 - 2006

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    KAWAZU Toshiyuki, NAKAYAMA Eiji, OKAMURA Kazutoshi, YOSHIURA Kazunori, TOKUMORI Kenji, CHIKUI Toru

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    Grant amount：\3700000 （ Direct expense: \3700000 ）

    Before the balloon dilation therapy of duct of salivary gland, we investigate the obstructive sialoadenitis. Ten cases of obstructive sialoadenitis were investigated. Results of investigation were listed below.
    1) Most (9 of 10) of the cases, obstruction arise from part of anterior border of masseter muscle.
    2) Duration of illness was not always correlated with gravity of patient's illness.
    3) Damage of peripheral duct of salivary gland was correlated with degree of excretion of contrast media.
    From the result of 1), it was thought that dilation therapy could be adapted to most of obstructive sialoadenitis.
    On the basis of above results, we performed two cases of balloon dilation therapy of obstructive sialoadenitis using PTCA balloon catheter. In first case, in spite of slight reduction of pain, dilation therapy had no apparent effect on obstructive sialoadenitis. The reason of such unsatisfactory was thought to be result from insufficient delivery of balloon catheter owing to curvature of salivary duct. In second case, although apex of balloon reached the portion of obstruction, we also had no effect on obstructive sialoadenitis, because dilation diameter was not enough for treatment
    From the results of two cases, it became clear that we must improve the instrument, especially both strength of catheter and dilation diameter of balloon.

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  • Interventional Radiology of Salivary gland

    2005

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    Grant type：Competitive

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  • 唾液腺のInterventioal Radiology

    2005

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    Grant type：Competitive

    種々のカテーテルを利用した唾液腺の各種疾患に対する治療

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  • Experimental Study on Development of Sialendoscopic Sialolithectomy System using Intracorporeal Electrohydraulic Lithotripsy

    Grant number：16592007  2004 - 2005

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    NAKAYAMA Eiji, KAWAZU Toshiyuki, NAKAMURA Norifumi, NAKAMARU Seiji, TOKUMORI Kenji, OKAMURA Kazutoshi

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    Grant amount：\3600000 （ Direct expense: \3600000 ）

    The purpose of this study was to establish a new endoscopic sialolithectomy system using intracorporeal electrohydraulic lithotripsy suitable for the non-surgical clinical use.
    We developed a fine sialendoscope, which could be introduced to the submandibular duct through the opening of sublingual caruncula without any incision. The sialendoscope, Salivascope T PD-ZS-2002 (POLYDIAGNOST GmbH, Pfaffenhofen, Germany) with a 1.35-mm outer diameter, has 3000-pixels optic fibers, a working channel, and an irrigation channel. The working channel has a 0.8-mm inner diameter so that a 1.9-Fr. probe of an electrohydraulic lithotripter can be inserted into the working channel. The electrohydraulic lithotripter used in this study is AUTOLITH^<【○!R】> (Northgate Technologies Inc., Elgin, U.S.A.), and a 1.9-Fr. probe, Micro II (Northgate Technologies Inc., Elgin, U.S.A.).
    We performed an experiment to destroy 9 sialoliths using above-mentioned lithotripsy system and analyze the relationship between the weight and size of the sialoliths and the generating parameters of shock wave in which the sialoliths were fragmented. The variable parameters were power level of operating voltage and total counters of shock wave. We also measured the quantity of heat generated by shooting the shock wave of each power level.
    As a result, 7 of 9 sialoliths (77.8%) were fragmented, and the parameters suitable for fragmentation of the sialoliths are correlated with the weight and size (long axis and short axis). The fragmentations were accomplished with the integrated effect of all shots of each power level. The heat quantity was 12.6 J at 50% of power level, and enough high to injure the duct of salivary gland. Therefore, cooling within the duct by irrigating cold saline is essential when this system is applied to the clinical practice.
    Thus, we concluded that this system is practical method to remove the sialolith non-surgically, although cooling of the duct should be needed during the procedure.
    Using this newly developed sialendoscopy system, we finally succeeded to remove a sialolith of the submandibular gland of a patient non-surgically with no severe complication.

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  • Optimum display of the digital intraoral imaging system by quantitative evaluation on image quality

    Grant number：16591888  2004 - 2005

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    YOSHIURA Kazunori, KAWAZU Toshiyuki, CHIKUI Toru, SHIMIZU Mayumi, TOKUMORI Kenji, YOSHINAKA Masanori

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    Grant amount：\3000000 （ Direct expense: \3000000 ）

    Digital system is widely used in medical imaging and this trend is found in general dental practitioners, too. However, no consensus was obtained about the optimum display of the digital image and information in the digital images are not fully used for diagnosis and treatment planning.
    In this study, low contrast detectability in the digital systems was compared with that in the film using specially developed image quality phantom for quantitative evaluation. Then diagnostic accuracy for proximal caries of the extracted teeth was evaluated using the same systems and the same observers.
    Regression analysis showed high correlation between low contrast detectability and diagnostic accuracy. There was no statistically significant difference between diagnostic accuracy of the digital systems and that of the film. Effect of exposure on diagnostic accuracy or low contrast detectability, however, was larger in the digital systems than in the film. This effect was smaller in the digital system with automatic exposure compensation than in that without it.
    Further investigation clarified that image contrast of the digital system was completely different from that of the film. Image contrast of the digital system in low exposure was far inferior to that of the film. We developed the image display algorithm to improve contrast in low exposure. The result showed that overall image contrast of the processed image was better than that of the original and it was similar to that of the film.
    This image display algorithm may have general applicability to all digital intraoral imaging systems.

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  • Automated quantitative diagnosis system for dental diseases by optimum image processing

    Grant number：14571791  2002 - 2003

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    YOSHIURA Kazunori, CHIKUI Toru, TOKUMORI Kenji, SHIMIZU Mayumi, KAWAZU Toshiyuki

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    Grant amount：\2900000 （ Direct expense: \2900000 ）

    Many studies have reported that diagnostic accuracy of the digital dental imaging system is comparable to films. It may be due to the inadequate image display of the digital data The purpose of this study was to obtain maximum image information from digital dental imaging system by applying optimum image display of the digital data. Further aim was to develop a computer-assisted diagnosis system using caries diagnosis algorithm and optimized images. The results obtained are as follows.
    1.Collection of digital image data
    Twenty-seven extracted teeth including caries of various grades were prepared. Pair of two teeth were radiographed with digital dental imaging system. Exposure time was varied in 8 steps including optimum exposure. Teeth were cut into halves and histopathology of proximal surfaces was assessed under the stereomicroscope. The final diagnoses were used as the "gold standards".
    2.Algorithm of automated outline extraction of proximal tooth surface
    To detect proximal tooth surface automatically, an algorithm was developed using Wavelet transforms. It was possible to extract exact proximal tooth surface automatically by using this method.
    3.Algorithm of automated caries diagnosis
    A region of interest (ROI) was set at the interproximal position. An algorithm was developed to measure the pixel value changes vertical to the tooth surface. By moving along the proximal tooth surface, a profile of the pixel value changes. along the proximal tooth surface with certain thickness was obtained. Several representative values of the pixel value change have been determined.
    4.Evaluation of the diagnostic accuracy of this system
    Automated caries diagnosis was performed using the representative values extracted above. The diagnostic accuracy of the present system was comparable to that of the observers and better over some of the observers. We consider this system may be useful as a computer-assisted diagnosis system for proximal caries diagnosis.

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  • Basic research on a 3D CT system using a CCD sensor for Oral Maxillofacial region

    Grant number：12470398  2000 - 2002

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    KANDA Shigenobu, OHKI Masafumu, TOYOFUKU Fukai, TOKUMORI Kenji, KAWAZU Toshiyuki, TANAKA Kakemasa

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    Grant amount：\13700000 （ Direct expense: \13700000 ）

    To investigate problems for developing a 3D CT system using a pinhole CCD sensor, 1) a simulation p program, 2) a reconstruction program, 3) a control system for four stepping motor and 4) a CCD control system were developed. By using the simulation program (1), numerical 2D projection data were obtained. The reconstruction images for the data were calculated by using the reconstruction program (2). These results made it possible to evaluate the propriety of the simulation program and the reconstruction program. The control system for four stepping motor (3) made it possible to control up to 4-axis moving. By developing the CCD control system, we could obtain direct projection images. Using all these developed programs and systems, tomographic images, the center of which was above the images obtained by a CCD sensor, could be obtained without problems. However, there is a problem to be left. The insufficient of the x-ray photons made it difficult to obtain the projection using a pinhole CCD sensor. We have to improve this problem in the future.

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  • Effect of thermotherapy on metastatic cervical lymphnode of oral cancer

    Grant number：12671829  2000 - 2001

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    KAWAZU Toshiyuki, YOSHINO Mayumi, CHIKUI Toru, YUASA Kenji, OHBU Kazunari, TOKUMORI Kenji

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    Grant amount：\3300000 （ Direct expense: \3300000 ）

    VX2 tumor cells were transplanted in oral floor of the white rabbits to develop the cervical lymph node metastasis. The thermotherapy was performed by using THERMOTRON-RF8.
    The thermo therapy failed to control the primary site in all 5 cases, and histopathologic assessment at the end of the follow-up period revealed local relapses due to incomplete thermo therapy. On Power Doppler US image obtained after thermotherapy, the internal blood flow disappeared within the primary site ; however, the residual perfusion was detected at periphery. Therefore, the residual blood flow at periphery might be attributed to the failure of the control of the primary site.
    In regard to the prevention of lymph node metastasis, the effectiveness of thermo therapy was still questionable. In the process of the lymph node metastasis, the vascularity increased at first, and later, the avasular area appeared and it became larger to be depicted as no signal within lymph node.
    If the metastasis was large enough to be detected as avascular area, the thermotherapy could not control the metastasis.
    If the tumor deposit was not so large to be detected as avascular area, viable tumor cells were completely disappeared in some nodes. In such nodes, the transient rich vascularity decreased after thermotherapy. The other nodes retained rich vascularity after thermotherapy and such nodes could not be controlled by thermotherapy. Therefore, in the microscopic metastasis, the disappearance of the depicted vessels obtained by power Doppler images was indicative of success of the thermotherapy.
    We think that the fixation of model animals and the evaluation of the three-dimensional thermal distribution are essential for success of the thermotherapy.

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  • Automated diagnosis system for dental diseases using functions of the humanvisual system

    Grant number：11671870  1999 - 2000

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    KAWAZU Toshiyuki, TOYOFUKU Fukai, TOKUMORI Kenji, TANAKA Takemasa

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    Grant amount：\3600000 （ Direct expense: \3600000 ）

    The purpose of this project was to obtain the function of the human visual system from the average observer and apply it to the proximal caries diagnosis as a semi-automated system.
    1.Effects of the human visual system on the proximal caries diagnosis
    Two types of recording media-the analogue film and the digital imaging films- were used for this experiment. The materials consisted of 27 third molar teeth extracted from young adolescents.Using these equipments and materials, a total of 594 digital images and 189 film radiographs were obtained. Seven oral radiologists evaluated one series at one time. Receiver operating characteristic (ROC) curves were obtained at each exposure of the recording system.
    In this experiment, it was concluded that radiation contrast registered by the recording medium determines the information required for the caries diagnosis. The effect of human visual system on the caries diagnosis was minimum.
    2.Semi-automated system for the proximal caries diagnosis
    Using the results from the above experiment, we have developed the semi-automated system for the proximal caries diagnosis.
    In this system, the algorithm for the caries diagnosis is following :
    1) extraction of the contour of the proximal surface
    2) gray level measurement along the horizontal axis
    3) gray level profile along the proximal surface
    4) polynomial curve fitting to the profile
    5) extraction of the parameters from the function
    6) discrimination function for the caries using the above parameters
    Diagnostic accuracy obtained from the semi-automated system was comparable to that of the observers. Especially, it was most effective in the system using automated exposure compensation program.
    Conclusion
    The present semi-automated system may be useful for the proximal caries diagnosis, especially in the system with automated exposure compensation.

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  • Experimental study for detecting cervical lymph node micro-metastasis using Doppler ultrasonography

    Grant number：10671770  1998 - 1999

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    YUASA Kenji, NAKANO Toshiaki, KAWAZU Toshiyuki, CHIKUI Toru, SAITO Michiyo, YOSHINO Mayumi

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    Grant amount：\2600000 （ Direct expense: \2600000 ）

    Results of this study were as follows :
    1. Power Doppler ultrasonography (US) of cervical metastatic lymph nodes in rabbit with oral carcinoma (VX2 carcinoma implanted) using high frequency transducers (14MHz) was compared with intranodal angiography. Power Doppler Us could present intranodal vascularization almost compatible to intranodal angiography. Therefore, it was considered that power Doppler Us was useful to assess the intranodal angioarchitecture.
    2. Histopathologic finding and angiography showed that intranodal vasculization increased transiently in early stage of the tumor growth in lymph node, and thereafter decreased as the tumor growth advanced. In some case, peripheral vascularization of metastatic lymph node was found in advanced stage of intranodal tumor growth. Power Doppler Us could also reveal these change of intranodal vascularization in the tumor growth process.
    3. Pulse Doppler Us showed that velocity of blood flow at hilar region increased transiently in early stage of the tumor growth in lymph node, thereafter decreased as the tumor growth advanced. The phase of the maximum velocity of blood flow at hilar region associated with the phase then focal area of no perfusion was shown.
    4. Pulse Doppler Us showed that the vessel at hilar region had beats as the velocity of the blood flow increased.
    5. Peripheral blood flow was found in some cases of the metastatic lymph nodes when area of no perfusion within lymph node was presented.
    6. Above results suggested that when tumor implants in lymph node, firstly the velocity blood flow at hilar increase, and then intranodal vascularization increase transiently, and thereafter intranodal vascularization decrease as the tumor growth advanced, accompanying with the presence of peripheral vascularization in some cases.
    7. It was considered that we could detect cervical lymph node metastasis in early stage (micro-metastasis) using Doppler US.

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  • Fast Energy Subtraction Using Fluorescent X-Rays Excited by Synchrotron Radiation

    Grant number：09470203  1997 - 1999

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    TOYOHUKU Fukai, KANDA Shigenobu, OHKI Masafumi, TOKUMORI Kenji, KAWADSU T., NAKAYAMA E.

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    Grant amount：\5800000 （ Direct expense: \5800000 ）

    A fast switching dual-energy fluorescent x-ray source for K-edge subtraction imaging has been developed using a 6.5 GeV synchrotron radiation storage ring at Tsukuba (KEK). The fluorescent x-ray source is composed of a cylindrical rotating target border of 25mm in diameter on which a pair of metal target strips of 2 - 5 mm in width are attached at a distance of 1mm apart. The surface of the target is angled at 45 degrees to the incident beam at the two points where it crosses the beam axis. At each time the incident white x-ray beam from the bending magnet, collimated to 1mm x 1mm, irradiates a pair of target materials, fluorescent x-rays of two different energy photons are generated at time intervals of about 10 msec at the rotation rate of 120 rpm.
    Fluorescent x-rays, which range from about 20 keV to 75 keV can be generated by changing the target materials. In case of iodine contrast medium, fluorescent x-rays from Ba and De, having 32.2 and 34.7 keV K x-ray energies respectively, can be used for K-edge subtraction of iodine which has K absorption edge of 33.17 keV. In case of gadolinium, fluorescent x-rays from Ho and Yb, having 47.5 and 52.4 keV K x-ray energies respectively, can be used for gadolinium K-edge of 50.23 keV.
    A phantom which contains iodine contrast medium is used for K-edge energy subtraction subject. By taking subtractions between two images above and below each K absorption edge, which are obtained by using an image intensifier and TV system, enhanced contrast material images are obtained.
    At present, the photon intensity is not sufficient for imaging of human subjects. High intensity fluorescent x-rays generated by synchrotron radiation will be useful for diagnostic radiology such as monochromatic-ray CT, K-edge subtraction imaging, high resolution magnification radiography, and other medical applications.

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  • DEVELOPMENT OF GLOBAL STANDARD PHANTOM TO OPTIMIZE DIGITAL

    Grant number：09671923  1997 - 1998

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    YOSHIURA Kazunori, YUASA Kenji, NAKAYAMA Eiji, TOKUMORI Kenji, TANAKA Takemasa, KAWAZU Toshiyuki

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    Grant amount：\3400000 （ Direct expense: \3400000 ）

    The purpose of this investigation was to develop a standard phantom for dental radiography and to compare image quality of film and digitally acquired images.
    First, an aluminum block of 12 steps with 7 holes covered by acrylic blocks was developed. This phantom was radio graphed with two types of films at 3 different tube voltages. The modified perceptibility curve was generated by counting maximum perceptible holes at each exposure. Optimum exposure level was determined from this curve and compared with that determined by means of the standard aluminum stepwedge and the preset time o the x-ray machine. The x-ray attenuation range for this phantom seemed to approximate clinical conditions. In addition, differences in image quality could be evaluated by means of the number of the holes seen in the phantom.
    Next, 2 film systems and several digital intraoral systems were compared with regard to visual image quality through use of this phantom. Modified perceptibility curves were created and compared each other. All digital systems except the Digora system showed lower optimum optimum exposures than E-speed film. In all digital images without enhancement, however, the maximum number of perceptible holes was significantly lower than that for the film systems at that exposure. With contrast enhancement, all digital systems except the Sens-A-Ray system showed visibility superior to that of the film systems. With CDR, Digora, and Dixel systems, exposures could be reduced by a considerable amount, with greater retention of information than was associated with film.
    These results strongly suggest that digital systems, if properly used, can exceed film systems in the detection of small mass changes.

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  • Consideration for Density Optimization and Dose Reduction of Digital Dental Imaging System Using Fuzzy Control

    Grant number：09671925  1997 - 1998

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    TANAKA Takemasa, KAWAZU Toshiyuki, TABATA Osamu, TOYOFUKU Fukai, TOKUMORI Kenji, YOSHIURA Kazunori

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    Grant amount：\3100000 （ Direct expense: \3100000 ）

    The digital dental imaging system (DDIS) has been developed and spread widely in recent years. The images of DDIS, however, aren't always so good, because of insufficient density distribution. Therefore, it seems that DDIS requires density optimization in an appropriate way. The authors applied the fuzzy reasoning and fuzzy c-means clustering algorithm for this purpose. According to our method, density distribution of most DDIS images could be improved better than the conventional histogram equalization method.
    Moreover, this method could be applied for the reduction of absorbed dose of the patients. If the exposure time is shorter than standard one and the density of the image is insufficient, the density can be compensated acoording to the method described as above. Consequently, it was suggested that the absorbed dose could be decreased 38.3%.

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  • CADを用いた頚部リンパ節転移の画像診断

    1995 - 2005

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    Grant type：Competitive

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  • Imaging diagnosis of cervical lymph node metastasis using Computer Aided Diagnosis

    1995 - 2005

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    Grant type：Competitive

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  • Differential Diagnosis between Ameloblastoma and Odontogenic Keratocyst Using Computed Tomography

    1995 - 2000

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    Grant type：Competitive

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  • エナメル上皮腫と歯原性角化嚢胞のCTによる画像診断学的比較

    1995 - 2000

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    Grant type：Competitive

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