Updated on 2022/10/01

写真a

 
NAKAMURA Kazufumi
 
Organization
Faculty of Medicine, Dentistry and Pharmaceutical Sciences Associate Professor
Position
Associate Professor
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Degree

  • 博士(医学) ( 岡山大学 )

Research Interests

  • 循環器内科

  • Cardiovascular Medicine

Research Areas

  • Life Science / Cardiology

Education

  • Okayama University    

    - 1998

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  • Okayama University   医学研究科   循環器内科学

    - 1998

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    Country: Japan

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  • Okayama University    

    - 1993

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  • Okayama University   医学部   医学科

    - 1993

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    Country: Japan

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Research History

  • - 岡山大学医歯薬学総合研究科 准教授

    2013

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  • - Associate Professor,Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama University

    2013

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  • Senior Assistant Professor,University Hospital of Medicine and Dentistry,Okayama University

    2010 - 2013

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  • Okayama University   Okayama University Hospital

    2010 - 2013

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Professional Memberships

 

Papers

  • Fragmented QRS as a predictor of cardiac events in patients with cardiac sarcoidosis. International journal

    Soichiro Ogura, Kazufumi Nakamura, Hiroshi Morita, Koji Nakagawa, Nobuhiro Nishii, Satoshi Akagi, Norihisa Toh, Yoichi Takaya, Masashi Yoshida, Toru Miyoshi, Atsuyuki Watanabe, Hiroshi Ito

    Journal of cardiology   2021.11

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    BACKGROUND: Multiple spikes within the QRS complex, known as fragmented QRS (fQRS), are associated with the occurrences of ventricular arrhythmic events (VAEs) in patients with Brugada syndrome and hypertrophic cardiomyopathy. However, the association between fQRS and occurrence of VAEs in patients with cardiac sarcoidosis (CS) has not been elucidated. METHODS: We evaluated the associations between fQRS and cardiac events including VAEs [non-sustained ventricular tachycardia (NSVT), sustained ventricular tachycardia (VT), and ventricular fibrillation (VF)], hospitalization for heart failure, and all-cause death in 68 patients with CS (30 patients with fQRS vs. 38 patients without fQRS) over a 5-year period. RESULTS: Cardiac events occurred in 22 patients with fQRS and 18 patients without fQRS (73% vs. 47%, p=0.009). Of the cardiac events that occurred in CS patients, VAEs occurred more frequently in patients with fQRS than in patients without fQRS (VAEs: 70% vs. 45%, p=0.017; NSVT: 70% vs. 45%, p=0.010; VT: 43% vs. 18%, p=0.011, and VF: 6.7% vs. 2.6%, p=0.34), whereas there was no significant difference in hospitalization for heart failure or all-cause death between patients with and those without fQRS (hospitalization for heart failure: 6.7% vs. 5.3%, p=0.75; all-cause death: 6.7% vs. 5.3%, p=0.64). Multivariate analysis showed that fQRS in the baseline electrocardiogram was independently associated with VAEs (hazard ratio: 2.21, 95% confidence interval: 1.15-4.25, p=0.017). CONCLUSION: fQRS is a predictor of VAEs in patients with CS.

    DOI: 10.1016/j.jjcc.2021.10.022

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  • Incremental prognostic value of non-alcoholic fatty liver disease over coronary computed tomography angiography findings in patients with suspected coronary artery disease. International journal

    Keishi Ichikawa, Toru Miyoshi, Kazuhiro Osawa, Takashi Miki, Hironobu Toda, Kentaro Ejiri, Masashi Yoshida, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Ito

    European journal of preventive cardiology   2021.7

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    AIMS: This study aimed to investigate additional risk stratification benefits of hepatic steatosis (HS) concurrently assessed during coronary computed tomography angiography (CTA) in a large patient cohort with suspected stable coronary artery disease (CAD). METHODS AND RESULTS: In this prospective study, 1148 Japanese outpatients without a history of CAD who underwent coronary CTA for suspected stable CAD (mean age 64 ± 14 years) were included. HS, defined on CT as a hepatic-to-spleen attenuation ratio of <1.0, was examined just before the evaluation of adverse CTA findings, defined as obstructive and/or high-risk plaque. The major adverse cardiac events (MACE) were the composite of cardiac death, acute coronary syndrome, and late revascularization. The incremental predictive value of HS was evaluated using the global χ2 test and C-statistic. HS was identified in 247 (22%) patients. During a median follow-up of 3.9 years, MACE was observed in 40 (3.5%) patients. HS was significantly associated with MACE in a model that included adverse CTA findings (hazard ratio 4.01, 95% confidence interval 2.12-7.59, P < 0.001). By adding HS to the Framingham risk score and adverse CTA findings, the global χ2 score and C-statistic significantly increased from 29.0 to 49.5 (P < 0.001) and 0.74 to 0.81 (P = 0.026), respectively. In subgroup analyses in patients with diabetes mellitus and metabolic syndrome, HS had significant additive predictive value for MACE over the Framingham risk score and adverse CTA findings. CONCLUSION: In patients with suspected stable CAD, concurrent evaluation of HS during coronary CTA enables more accurate detection of patients at higher risk of MACE.

    DOI: 10.1093/eurjpc/zwab120

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  • Prognostic value of non-alcoholic fatty liver disease for predicting cardiovascular events in patients with diabetes mellitus with suspected coronary artery disease: a prospective cohort study. International journal

    Keishi Ichikawa, Toru Miyoshi, Kazuhiro Osawa, Takashi Miki, Hironobu Toda, Kentaro Ejiri, Masatoki Yoshida, Yusuke Nanba, Masashi Yoshida, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Ito

    Cardiovascular diabetology   20 ( 1 )   8 - 8   2021.1

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    BACKGROUND: Risk stratification of cardiovascular events in patients with type 2 diabetes mellitus (T2DM) has not been established. Coronary artery calcium score (CACS) and non-alcoholic fatty liver disease (NAFLD) are independently associated with cardiovascular events in T2DM patients. This study examined the incremental prognostic value of NAFLD assessed by non-enhanced computed tomography (CT) in addition to CACS and Framingham risk score (FRS) for cardiovascular events in T2DM patients. METHODS: This prospective pilot study included 529 T2DM outpatients with no history of cardiovascular disease who underwent CACS measurement because of suspected coronary artery disease. NAFLD was defined on CT images as a liver:spleen attenuation ratio < 1.0. Cardiovascular events were defined as cardiovascular death, nonfatal myocardial infarction, late coronary revascularization, nonfatal stroke, or hospitalization for heart failure. RESULTS: Among 529 patients (61% men, mean age 65 years), NAFLD was identified in 143 (27%). Forty-four cardiovascular events were documented during a median follow-up of 4.4 years. In multivariate Cox regression analysis, NAFLD, CACS, and FRS were associated with cardiovascular events (hazard ratios and 95% confidence intervals 5.43, 2.82-10.44, p < 0.001; 1.56, 1.32-1.86, p < 0.001; 1.23, 1.08-1.39, p = 0.001, respectively). The global χ2 score for predicting cardiovascular events increased significantly from 27.0 to 49.7 by adding NAFLD to CACS and FRS (p < 0.001). The addition of NAFLD to a model including CACS and FRS significantly increased the C-statistic from 0.71 to 0.80 (p = 0.005). The net reclassification achieved by adding CACS and FRS was 0.551 (p < 0.001). CONCLUSIONS: NAFLD assessed by CT, in addition to CACS and FRS, could be useful for identifying T2DM patients at higher risk of cardiovascular events.

    DOI: 10.1186/s12933-020-01192-4

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  • Usefulness of right ventriculography compared with computed tomography for ruling out the possibility of lead perforation before lead extraction. International journal

    Saori Asada, Nobuhiro Nishii, Takayoshi Shinya, Akihito Miyoshi, Yoshimasa Morimoto, Masakazu Miyamoto, Koji Nakagawa, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Ito

    PloS one   16 ( 3 )   e0245502   2021

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    PURPOSE: High-risk patients can be identified by preprocedural computed tomography (CT) before lead extraction. However, CT evaluation may be difficult especially for lead tip identification due to artifacts in the leads. Selective right ventriculography (RVG) may enable preprocedural evaluation of lead perforation. We investigated the efficacy of RVG for identifying right ventricular (RV) lead perforation compared with CT in patients who underwent lead extraction. METHODS: Ninety-five consecutive patients who were examined by thin-section non-ECG-gated multidetector CT and RVG before lead extraction were investigated retrospectively. Newly recognized pericardial effusion after lead extraction was used as a reference standard for lead perforation. We analyzed the prevalence of RV lead perforation diagnosed by each method. The difference in the detection rates of lead perforation by RVG and CT was evaluated. RESULTS: Of the 115 RV leads in the 95 patients, lead perforation was diagnosed for 35 leads using CT, but the leads for 29 (83%) of those 35 leads diagnosed as lead perforation by CT were shown to be within the right ventricle by RVG. Three patients with 5 leads could not be evaluated by CT due to motion artifacts. The diagnostic accuracies of RVG and CT were significantly different (p < 0.001). There was no complication of pericardial effusion caused by RV lead extraction. CONCLUSION: RVG for identification of RV lead perforation leads to fewer false-positives compared to non-ECG-gated CT. However, even in cases in which lead perforation is diagnosed, most leads may be safely extracted by transvenous lead extraction.

    DOI: 10.1371/journal.pone.0245502

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  • 心アミロイドーシスの療 総論 (心不全, 不整脈, 血栓塞栓症に対する治療)

    宮本真和, 中村一文

    24 ( 11 )   1078 - 1083   2020.11

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    Authorship:Last author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  • 救急外来での見逃し(Missed)を避けるべき心原性失神10 real cases approach

    藤本 竜平, 森田 宏, 間瀬 浩, 三木 崇史, 戸田 洋伸, 杜 徳尚, 西井 伸洋, 中村 一文, 鈴木 洋, 伊藤 浩

    日本救急医学会雑誌   31 ( 11 )   2280 - 2280   2020.11

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  • Chemoradiation therapy for non-small cell lung cancer exacerbates thoracic aortic calcification determined by computed tomography Reviewed

    Heart Vessels   35 ( 10 )   1401 - 1408   2020.10

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  • Combination therapy with pemafibrate (K-877) and pitavastatin improves vascular endothelial dysfunction in dahl/salt-sensitive rats fed a high-salt and high-fat diet Reviewed

    Yoshida M, Nakamura K, Miyoshi T, Yoshida M, Kondo M, Akazawa K, Kimura T, Ohtsuka H, Ohno Y, Miura D, Ito H

    Cardiovasc Diabetol   19 ( 1 )   149   2020.9

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  • Effect of Luseogliflozin on Heart Failure With Preserved Ejection Fraction in Patients With Diabetes Mellitus Reviewed

    Ejiri K, Miyoshi T, Kihara H, Hata Y, Nagano T, Takaishi A, Toda H, Nanba S, Nakamura Y, Akagi S, Sakuragi S, Minagawa T, Kawai Y, Nishii N, Fuke S, Yoshikawa M, Nakamura K, Ito H; MUSCAT‐HF Study Investigators

    J Am Heart Assoc   9 ( 16 )   e015103   2020.8

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  • 松田論文に対するEditoial Comment –SIADHの診断と治療

    中村一文

    心臓   52 ( 8 )   897   2020.8

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    Authorship:Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Effects of Eicosapentaenoic Acid on Arterial Calcification Reviewed

    Saito Y, Nakamura K, Ito H

    Int J Mol Sci   21 ( 15 )   5455   2020.7

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  • Prognostic Value of Coronary Computed Tomographic Angiography in Patients With Nonalcoholic Fatty Liver Disease Reviewed

    Ichikawa K, Miyoshi T, Osawa K, Miki T, Nakamura K, Ito H

    JACC Cardiovasc Imaging   13 ( 7 )   1628 - 1630   2020.7

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  • 循環器内科医が生理査に期待するもの-無くてはならない心電図・超音波-

    中村一文

    生物試料分析   43 ( 3 )   171 - 175   2020.6

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    Authorship:Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  • 【臨床医が知っていてほしい循環器基礎研究最新の成果】心不全 酸化ストレスは心不全の原因か?

    中村一文、網岡尚史、三好 亨、伊藤 浩

    循環器内科   87 ( 5 )   597 - 600   2020.5

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  • Deficiency of CD44 prevents thoracic aortic dissection in a murine model Reviewed

    Hatipoglu OF, Miyoshi T, Yonezawa T, Kondo M, Amioka N, Yoshida M, Akagi S, Nakamura K, Hirohata S, Ito H

    Sci Rep   10 ( 1 )   6869   2020.4

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  • Effects of Bisoprolol Transdermal Patches for Prevention of Perioperative Myocardial Injury in High-Risk Patients Undergoing Non-Cardiac Surgery - Multicenter Randomized Controlled Study Reviewed

    Toda H, Nakamura K, Shimizu K, Ejiri K, Iwano T, Miyoshi T, Nakagawa K, Yoshida M, Watanabe A, Nishii N, Hikasa Y, Hayashi M, Morita H, Morimatsu H, Ito H; MAMACARI Investigators.

    Circ J   84 ( 4 )   642 - 649   2020.3

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  • Effects of Bisoprolol Transdermal Patches for Prevention of Perioperative Myocardial Injury in High-Risk Patients Undergoing Non-Cardiac Surgery - Multicenter Randomized Controlled Study. Reviewed

    Hironobu Toda, Kazufumi Nakamura, Kazuyoshi Shimizu, Kentaro Ejiri, Takayuki Iwano, Toru Miyoshi, Koji Nakagawa, Masashi Yoshida, Atsuyuki Watanabe, Nobuhiro Nishii, Yukiko Hikasa, Masao Hayashi, Hiroshi Morita, Hiroshi Morimatsu, Hiroshi Ito

    Circulation journal : official journal of the Japanese Circulation Society   84 ( 4 )   642 - 649   2020.3

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    BACKGROUND: The aim of this study was to evaluate the efficacy and safety of transdermal β-blocker patches, which offer stable blood concentration and easy availability during operation, for prevention of perioperative myocardial injury (PMI) in high-risk patients.Methods and Results:In this randomized controlled trial, patients aged >60 years with hypertension and high revised cardiac risk index (≥2) undergoing non-cardiac surgery were randomly assigned to a bisoprolol patch or control group. Primary efficacy outcome was incidence of PMI, defined as postoperative high-sensitivity cardiac troponin T (hs-cTnT) >0.014ng/mL and relative hs-cTnT change ≥20%. Secondary efficacy outcomes were number of cardiovascular events and 30-day mortality. From November 2014 to February 2019, 240 patients from 5 hospitals were enrolled in this study. The incidence of PMI was 35.7% in the bisoprolol patch group and 44.5% in the control group (P=0.18). Incidence of major adverse cardiac events including non-critical myocardial infarction, strokes, decompensated heart failure and tachyarrhythmia was similar between the 2 groups. Tachyarrhythmia tended to be higher in the control group. There were no significant differences in safety outcomes including significant hypotension and bradycardia requiring any treatment between the 2 groups. CONCLUSIONS: Bisoprolol patches do not influence the incidence of PMI and cardiovascular events in high-risk patients undergoing non-cardiac surgery, but perioperative use of these patches is safe.

    DOI: 10.1253/circj.CJ-19-0871

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  • Successful Transition from Phosphodiesterase-5 Inhibitors to Riociguat Without a Washout Period in Patients With Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension: A Pilot Cohort Study Reviewed

    Kuroda K, Akagi S, Nakamura K, Sarashina T, Ejiri K, Ito H

    Heart Lung Circ   29 ( 3 )   331 - 336   2020.3

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  • 【第6回世界肺高血圧学会2018のステートメントを読み解く アンメット・メディカル・ニーズは解決されたのか?】右心室および肺循環の病態生理学

    中村一文, 赤木 達, 江尻健太郎, 伊藤 浩

    呼吸器内科   37 ( 3 )   233 - 237   2020.3

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  • New Appearance of Fragmented QRS as a Predictor of Ventricular Arrhythmic Events in Patients With Hypertrophic Cardiomyopathy Reviewed

    Ogura S, Nakamura K, Morita H, Toh N, Nakagawa K, Yoshida M, Watanabe A, Nishii N, Miyoshi T, Ito H

    Circ J   84 ( 3 )   487 - 494   2020.2

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  • Lifestyle Modification or Medication to Improve Condition of Patients With Asymptomatic Heart Failure - Monitoring and Management of OptiVol Alert to Reduce Heart Failure Hospitalization II (MOMOTARO II) Study Reviewed

    84 ( 3 )   456 - 462   2020.2

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  • New Appearance of Fragmented QRS as a Predictor of Ventricular Arrhythmic Events in Patients With Hypertrophic Cardiomyopathy.

    Soichiro Ogura, Kazufumi Nakamura, Hiroshi Morita, Norihisa Toh, Koji Nakagawa, Masashi Yoshida, Atsuyuki Watanabe, Nobuhiro Nishii, Toru Miyoshi, Hiroshi Ito

    Circulation journal : official journal of the Japanese Circulation Society   84 ( 3 )   487 - 494   2020.2

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    BACKGROUND: Multiple spikes in the QRS complex (fragmented QRS [fQRS]) on 12-lead electrocardiography have been associated with ventricular arrhythmic events (VAEs) in patients with hypertrophic cardiomyopathy (HCM). The aim of this study was to assess the association between new appearances of fQRS and cardiac events in patients with HCM.Methods and Results:The association between baseline fQRS and cardiac events, namely VAEs, heart failure-related hospitalization, and all-cause death, was evaluated retrospectively in 146 HCM patients (46 patients with fQRS, 100 without fQRS). The median follow-up was 5.3 years. Cardiac events occurred in 29 patients with baseline fQRS and 32 patients without baseline fQRS (63% vs. 32%; P<0.001). VAEs occurred in a significantly larger percentage of patients with than without baseline fQRS (54% vs. 23%, respectively; P<0.001). Of the 100 patients without baseline fQRS, 33 had a new appearance of fQRS during the 4.6-year follow-up, whereas 67 did not. VAEs occurred more frequently in the 33 patients with the appearance of fQRS than in those without (42% vs. 13%, respectively; P=0.001). Multivariable analysis showed that the new appearance of fQRS documented before VAEs was associated with VAEs (hazard ratio 4.29, 95% confidence interval 1.81-10.2; P=0.001). CONCLUSIONS: The new appearance of fQRS was associated with an increased risk of VAEs in HCM patients.

    DOI: 10.1253/circj.CJ-19-0968

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  • Lifestyle Modification or Medication to Improve Condition of Patients With Asymptomatic Heart Failure - Monitoring and Management of OptiVol Alert to Reduce Heart Failure Hospitalization II (MOMOTARO II) Study.

    Akihito Miyoshi, Nobuhiro Nishii, Yoji Okamoto, Shinpei Fujita, Kenji Kawamoto, Keisuke Okawa, Shigeki Hiramatsu, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Ito

    Circulation journal : official journal of the Japanese Circulation Society   84 ( 3 )   456 - 462   2020.2

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    BACKGROUND: In heart failure (HF) patients implanted with high-energy devices, worsening of HF can be diagnosed from intrathoracic impedance (ITI) before symptoms appear. Early therapeutic intervention can prevent HF worsening, but the optimal intervention remains unknown. This study aimed to examine which lifestyle modifications or medications can improve HF indicators in asymptomatic HF patients diagnosed from ITI.Methods and Results:This multicenter, prospective, randomized study included patients with high-energy devices, left ventricular ejection fraction <40%, or with a history of HF hospitalization. After the OptiVol alert was evoked by decreased ITI, patients underwent examinations. If they were diagnosed with HF, they were randomly assigned to 3 groups: lifestyle modification, diuretic, or nitrate. After 1 week, they underwent the same examinations. The primary endpoint was change in ITI and serum B-type natriuretic peptide (BNP). Totally, 57 patients were randomized. In all 3 groups, ITI was significantly increased post-intervention compared with pre-intervention. In the diuretic and nitrate groups, logBNP post-intervention was significantly lower than pre-intervention, but not in the lifestyle modification group. CONCLUSIONS: Compared with lifestyle modifications, diuretic and nitrate therapy for 1 week may be more effective management of HF detected by decreased ITI. However, lifestyle modification may have the additional benefits of reducing the workload or cost.

    DOI: 10.1253/circj.CJ-19-0986

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  • Chemotherapy Improved Pulmonary Arterial Hypertension in a Patient with Chronic-Active Epstein-Barr Virus Infection Reviewed

    Akagi S, Miki T, Sando Y, Fujii N, Sarashina T, Nakamura K, Ito H

    Int Heart J   61 ( 1 )   191 - 194   2020.1

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  • Marked Reduction of Pulmonary Artery Pressure After Registration for Lung Transplantation Is Associated With Long-Term Survival in Patients With Pulmonary Arterial Hypertension - Cohort Study Reviewed

    Akagi S, Matsubara H, Nakamura K, Oto T, Ejiri K, Ito H

    Circ J   84 ( 2 )   245 - 251   2020.1

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  • Fontan術後の複数の心房頻拍に対しRythmiaによるカテーテルアブレーションとTCPC conversionが奏功した1例

    森本芳正, 西井伸洋, 水野智文, 浅田早央莉, 木村朋生, 宮本真和, 中川晃志, 渡邊敦之, 中村一文, 伊藤 浩, 栄徳隆裕, 笠原真悟

    日本成人先天性心疾患学会雑誌   9 ( 1 )   247   2020.1

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  • Low Consultation Rate of General Population with Atrial Fibrillation.

    Hiroaki Matsumi, Kazufumi Nakamura, Eri Eguchi, Toru Miyoshi, Koji Nakagawa, Nobuhiro Nishii, Atsuyuki Watanabe, Akira Ueoka, Masashi Yoshida, Naoto Tokunaga, Naofumi Amioka, Nobuyuki Yamada, Daiji Saito, Hiroshi Morita, Keiki Ogino, Hiroshi Ito

    International heart journal   60 ( 6 )   1303 - 1307   2019.11

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    In order to prevent ischemic stroke, it is important to identify and treat patients with atrial fibrillation (AF) who do not consult a doctor in a medical institution. The aim of this study was to determine the consultation rate at medical institutions for patients with AF in group medical examinations conducted in a city in western Japan. Of 6101 examinees of group medical examinations (40 years of age or older) conducted in Ibara City, Okayama Prefecture, Japan, from 2012 to 2014, 4338 participants (71.1%) who were evaluated by electrocardiogram (ECG) gave written informed consent and responded to surveys in the form of questionnaires through a personal interview conducted by nurses were included in the Ibara-AF study. A cumulative total of 82 subjects were diagnosed as having AF by ECG (prevalence of AF = 1.89%), and 51 individuals had AF during the three-year period.15 (29.4%) of the 51 patients with AF did not regularly visit medical institutions. Among them, 46.7% (n = 7) and 53.3% (n = 8) of the patients were symptomatic and asymptomatic, respectively, and 73.3% of the patients had a CHADS2 score of more than one point. There were no significant differences in patients' characteristics between regular and non-regular visit groups. In conclusion, about one-third of the patients with AF did not regularly see a doctor in a medical institution and most of them had a CHADS2 score of more than one point in a Japanese rural area. Educating the public about the risks of AF is required.

    DOI: 10.1536/ihj.19-062

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  • Efficacy of catheter ablation for paroxysmal atrial fibrillation in patients with atrial septal defect: a comparison with transcatheter closure alone

    Koji Nakagawa, Teiji Akagi, Satoshi Nagase, Yoichi Takaya, Yasufumi Kijima, Norihisa Toh, Atsuyuki Watanabe, Nobuhiro Nishii, Kazufumi Nakamura, Hiroshi Morita, Kengo Kusano, Hiroshi Ito

    EP Europace   21 ( 11 )   1663 - 1669   2019.11

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    <title>Abstract</title>
    <sec>
    <title>Aims</title>
    There is no valid treatment strategy for addressing paroxysmal atrial fibrillation (AF) in patients with unclosed atrial septal defect (ASD). We aimed to assess the efficacy of catheter ablation (CA) compared with transcatheter ASD closure alone for treating pre-existing paroxysmal AF in patients with ASD.


    </sec>
    <sec>
    <title>Methods and results</title>
    Among 908 patients who underwent transcatheter ASD closure, we evaluated 50 consecutive patients (63 ± 12 years) with paroxysmal AF. We compared the AF outcomes of these patients after transcatheter ASD closure between those with and without CA prior to ASD closure. Thirty (60%) patients underwent CA. During the follow-up period after ASD closure (mean: 49 ± 23 months), recurrence of AF was observed in 6/30 (20%) patients with upfront CA and 12/20 (60%) patients with ASD closure alone. Kaplan–Meier analysis showed that the AF-free survival rate was significantly higher for patients with CA than for those with ASD closure alone (79% vs. 37% at 5 years, P = 0.002). Upfront CA and previous heart failure hospitalization were associated with recurrence of AF after ASD closure [hazard ratio (HR) 0.18, 95% confidence interval (CI) 0.06–0.53; P = 0.002 and HR 4.64, 95% CI 1.60–13.49; P = 0.005, respectively].


    </sec>
    <sec>
    <title>Conclusion</title>
    In ASD patient with paroxysmal AF, transcatheter ASD closure alone demonstrated high AF recurrence rate after ASD closure. On the other hand, upfront CA prior to ASD closure substantially suppressed AF recurrence over the long term. A combination of CA and transcatheter ASD closure may be a feasible treatment strategy for paroxysmal AF in patients with ASD.


    </sec>

    DOI: 10.1093/europace/euz207

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  • 遺残坐骨動脈瘤に対しステントグラフト(VIABAHN)を用いて治療した一例 Reviewed

    大塚 寛昭, 戸田 洋伸, 江尻 健太郎, 杜 徳尚, 三好 亨, 中村 一文, 伊藤 浩

    日本心血管インターベンション治療学会抄録集   28回   [MP34 - 006]   2019.9

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  • A Low Critical Event Rate Despite a High Abnormal Event Rate in Patients with Cardiac Implantable Electric Devices Followed Up by Remote Monitoring.

    Yoshimasa Morimoto, Nobuhiro Nishii, Saori Tsukuda, Satoshi Kawada, Masakazu Miyamoto, Akihito Miyoshi, Koji Nakagawa, Atsuyuki Watanabe, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Ito

    Internal medicine (Tokyo, Japan)   58 ( 16 )   2333 - 2340   2019.8

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    Objective Remote monitoring (RM) of cardiac implantable electric devices (CIEDs) has been advocated as a healthcare standard. However, expert consensus statements suggest that all patients require annual face-to-face follow-up consultations at outpatient clinics even if RM reveals no episodes. The objective of this study was to determine the critical event rate after CIED implantation through RM. Methods This multicenter, retrospective, cohort study evaluated patients with pacemakers (PMs), implantable cardioverter defibrillators (ICDs), or cardiac resynchronization therapy defibrillator (CRT-Ds) and analyzed whether or not the data drawn from RM included abnormal or critical events. Patients A total of 1,849 CIED patients in 12 hospitals who were followed up by the RM center in Okayama University Hospital were included in this study. Results During the mean follow-up period of 774.9 days, 16,560 transmissions were analyzed, of which 11,040 (66.7%) were abnormal events and only 676 (4.1%) were critical events. The critical event rate in the PM group was significantly lower than that in the ICD or CRT-D groups (0.9% vs. 5.0% or 5.9%, p<0.001). A multivariate analysis revealed that ICD, CRT-D, and a low ejection fraction were independently associated with critical events. In patients with ICD, the independent risk factors for a critical event were old age, low ejection fraction, Brugada syndrome, dilated phase hypertrophic cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy. Conclusion Although abnormal events were observed in two-thirds of the transmitted RM data, the critical event rate was <1% in patients with a PM, which was lower in comparison to the rates in patients with ICDs or CRT-Ds. A low ejection fraction was an independent predictor of critical events.

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  • Combination of Renal Angioplasty and Angiotensin-converting-enzyme Inhibitor Can Reduce Proteinuria in Patients with Bilateral Renal Artery Disease. Reviewed

    Hironobu Toda, Haruhito Uchida, Kazufumi Nakamura, Hidemi Takeuchi, Masaru Kinomura, Koji Nakagawa, Atsuyuki Watanabe, Toru Miyoshi, Nobuhiro Nishii, Hiroshi Morita, Jun Wada, Hiroshi Ito

    Internal medicine (Tokyo, Japan)   58 ( 13 )   1917 - 1922   2019.7

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    Recent large clinical trials failed to show clear benefits of percutaneous transluminal renal angioplasty (PTRA) as compared with medical therapy on patients with renal artery stenosis. It was also reported that proteinuria is an adverse prognostic factor after PTRA, and PTRA is less effective in patients with overt proteinuria. From the renoprotective point of view, to reduce proteinuria after PTRA is an important therapeutic goal in patients with renal artery stenosis with overt proteinuria. We hereby describe two patients successfully treated by combination therapy with PTRA and administration of angiotensin-converting enzyme (ACE) inhibitor for bilateral renal artery disease with overt proteinuria.

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  • The optimal amount of salt intake. International journal

    Kazufumi Nakamura, Toru Miyoshi

    Hypertension research : official journal of the Japanese Society of Hypertension   42 ( 5 )   752 - 753   2019.5

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  • Successful radiofrequency catheter ablation of a premature ventricular contraction triggering ventricular fibrillation in a patient with short QT syndrome. International journal

    Yoshimasa Morimoto, Atsuyuki Watanabe, Hiroshi Morita, Nobuhiro Nishii, Kazufumi Nakamura, Hiroshi Ito

    HeartRhythm case reports   5 ( 5 )   262 - 265   2019.5

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  • CLI診療(循環器内科医に求められる役割について) Reviewed

    大塚 寛昭, 戸田 洋伸, 江尻 健太郎, 三好 亨, 中村 一文, 森田 宏, 伊藤 浩

    日本下肢救済・足病学会誌   11 ( 1 )   58 - 58   2019.4

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  • Radiofrequency catheter ablation prior to percutaneous coronary intervention in patients with atrial fibrillation coexisting with stable coronary artery disease: a single-center pilot study.

    Satoshi Kawada, Atsuyuki Watanabe, Yoshimasa Morimoto, Koji Nakagawa, Nobuhiro Nishii, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Ito

    Heart and vessels   34 ( 4 )   632 - 640   2019.4

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    Atrial fibrillation (AF) frequently coexists with cardiovascular disease (CAD) in a clinical setting. However, the optimum therapy for AF patients who have concomitant CAD is unclear. We retrospectively examined the efficacy and safety of radiofrequency catheter ablation (RFCA) prior to percutaneous coronary intervention (PCI) in patients with AF who had concomitant stable CAD. Between January 2014 and December 2015, a total 264 patients (179 men; mean age, 65.5 ± 10.1 years) who were referred to undergo a first RFCA procedure were reviewed in this study. Of the 264 patients, 41 (15.5%) had stable CAD detected by multi-detector computed tomography before RFCA. Thirty-seven patients who had AF with stable CAD were divided into two treatment arms: (1) RFCA prior to PCI (n = 13) and (2) PCI prior to RFCA (n = 24) [four patients excluded because of left main coronary artery disease (LMCA) or triple vessel disease (TVD)]. The median follow-up was 14 (IQR 8-19) months. There was no significant difference in AF recurrence rate after the procedure between the RFCA first group and PCI first group (P = 0.515). No symptomatic cardiovascular events occurred the during follow-up period. The PCI first group had a significantly longer duration of triple therapy (188.5 ± 167 days vs 5.6 ± 24.5 days, P = 0.01) and all of the four bleeding events occurred during triple therapy (P = 0.01). The results of this single-center pilot study suggested that prior RFCA in patients with AF coexisting with CAD could have fewer serious bleeding events than prior PCI.

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  • Coral reef aorta一連の病変と考えられた移植腎動脈狭窄に対する血管内治療の1例 Reviewed

    戸田 洋伸, 大塚 寛昭, 江尻 健太郎, 内田 治仁, 杜 徳尚, 中川 晃志, 渡邊 敦之, 三好 亨, 西井 伸洋, 中村 一文, 森田 宏, 伊藤 浩

    脈管学   58 ( Suppl. )   S206 - S206   2018.9

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  • Corrigendum to "Serum cystatin C levels are associated with coronary artery calcification in women without chronic kidney disease" [J. Cardiol. 70 (2017) 559-564]. International journal

    Hiroyasu Sugiyama, Toru Miyoshi, Kazuhiro Osawa, Takashi Miki, Yuji Koide, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Ito

    Journal of cardiology   72 ( 3 )   267 - 268   2018.9

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  • 重度低心機能患者に発症した重症下肢虚血、糖尿病性壊疽に対し集学的治療を行った一例 Reviewed

    大塚 寛昭, 戸田 洋伸, 江尻 健太郎, 奥山 倫弘, 大澤 晋, 山田 潔, 三好 亨, 中村 一文, 伊藤 浩

    日本下肢救済・足病学会誌   10 ( 1 )   83 - 83   2018.6

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  • HCN4-Overexpressing Mouse Embryonic Stem Cell-Derived Cardiomyocytes Generate a New Rapid Rhythm in Rats with Bradycardia.

    Yukihiro Saito, Kazufumi Nakamura, Masashi Yoshida, Hiroki Sugiyama, Makoto Takano, Satoshi Nagase, Hiroshi Morita, Kengo F Kusano, Hiroshi Ito

    International heart journal   59 ( 3 )   601 - 606   2018.5

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    A biological pacemaker is expected to solve the persisting problems of an artificial cardiac pacemaker including short battery life, lead breaks, infection, and electromagnetic interference. We previously reported HCN4 overexpression enhances pacemaking ability of mouse embryonic stem cell-derived cardiomyocytes (mESC-CMs) in vitro. However, the effect of these cells on bradycardia in vivo has remained unclear. Therefore, we transplanted HCN4-overexpressing mESC-CMs into bradycardia model animals and investigated whether they could function as a biological pacemaker. The rabbit Hcn4 gene was transfected into mouse embryonic stem cells and induced HCN4-overexpressing mESC-CMs. Non-cardiomyocytes were removed under serum/glucose-free and lactate-supplemented conditions. Cardiac balls containing 5 × 103 mESC-CMs were made by using the hanging drop method. One hundred cardiac balls were injected into the left ventricular free wall of complete atrioventricular block (CAVB) model rats. Heart beats were evaluated using an implantable telemetry system 7 to 30 days after cell transplantation. The result showed that ectopic ventricular beats that were faster than the intrinsic escape rhythm were often observed in CAVB model rats transplanted with HCN4-overexpressing mESC-CMs. On the other hand, the rats transplanted with non-overexpressing mESC-CMs showed sporadic single premature ventricular contraction but not sustained ectopic ventricular rhythms. These results indicated that HCN4-overexpressing mESC-CMs produce rapid ectopic ventricular rhythms as a biological pacemaker.

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  • 開胸マッピングにより右室心外膜側に多彩な異常電位を認めた孤発性無症候Brugada症候群の1例

    渡邊 敦之, 森田 宏, 川田 哲史, 森本 芳正, 橘 元見, 中川 晃志, 西井 伸洋, 中村 一文, 伊藤 浩, 衛藤 弘城, 増田 善逸, 佐野 俊二

    臨床心臓電気生理   41   123 - 126   2018.5

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  • TRPM4 Mutation in Patients With Ventricular Noncompaction and Cardiac Conduction Disease. International journal

    Yukihiro Saito, Kazufumi Nakamura, Nobuhiro Nishi, Osamu Igawa, Masashi Yoshida, Toru Miyoshi, Atsuyuki Watanabe, Hiroshi Morita, Hiroshi Ito

    Circulation. Genomic and precision medicine   11 ( 5 )   e002103   2018.5

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    DOI: 10.1161/CIRCGEN.118.002103

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  • Platypnea-orthodeoxia Syndrome Induced by Multiple Vertebral Compression Fractures and an Atrial Septal Defect.

    Ko Harada, Koji Nakagawa, Hiroaki Ohtsuka, Yoichi Takaya, Teiji Akagi, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Ito

    Internal medicine (Tokyo, Japan)   57 ( 7 )   971 - 973   2018.4

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    Platypnea-orthodeoxia syndrome (POS) is a rare condition that is characterized by dyspnea and arterial oxygen desaturation, which worsen on standing and which are relieved by recumbency. We treated an 80-year-old woman with an atrial septal defect (ASD) who demonstrated POS following thoracic and lumbar vertebral compression fractures. The surgical closure of the ASD relieved her symptoms. The etiology might have been multiple compression fractures causing kyphosis and aortic distortion producing right atrial compression and increased right-to-left flow through the ASD. POS should be considered in the differential diagnosis of patients who develop dyspnea after vertebral compression fractures. The careful assessment of the patient's history and clinical condition helps in the diagnosis of POS.

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  • Diastolic Dysfunction Is a Risk of Perioperative Myocardial Injury Assessed by High-Sensitivity Cardiac Troponin T in Elderly Patients Undergoing Non-Cardiac Surgery. Reviewed

    Hironobu Toda, Kazufumi Nakamura, Koji Nakagawa, Atsuyuki Watanabe, Toru Miyoshi, Nobuhiro Nishii, Kazuyoshi Shimizu, Masao Hayashi, Hiroshi Morita, Hiroshi Morimatsu, Hiroshi Ito

    Circulation journal : official journal of the Japanese Circulation Society   82 ( 3 )   775 - 782   2018.2

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    BACKGROUND: High-sensitivity cardiac troponin T (hs-cTnT) is useful for detecting myocardial injury and is expected to become a prognostic marker in patients undergoing non-cardiac surgery. The aim of this pilot study evaluating the efficacy of β-blocker therapy in a perioperative setting (MAMACARI study) was to assess perioperative myocardial injury (PMI) in elderly patients with preserved ejection fraction (EF) undergoing non-cardiac surgery.Methods and Results:In this prospective observational cohort study of 151 consecutive patients with preserved EF and aged >60 years who underwent non-cardiac surgery, serum levels of hs-cTnT were measured before and on postoperative days 1 and 3 after surgery. PMI was defined as postoperative hs-cTnT >0.014 ng/mL and relative hs-cTnT change ≥20%. A total of 36 (23.8%) of the patients were diagnosed as having PMI. The incidence of a composite of cardiovascular events within 30 days after surgery, including myocardial infarction, stroke, worsening heart failure, atrial fibrillation and pulmonary embolism, was significantly higher in patients with PMI than in patients without PMI (odds ratio (OR) 9.25, P<0.001, 95% confidence interval (CI) 2.65-32.3). Multivariate analysis revealed that left ventricular diastolic dysfunction defined by echocardiography was independently associated with PMI (OR: 3.029, 95% CI: 1.341-6.84, P=0.008). CONCLUSIONS: PMI is frequently observed in elderly patients undergoing non-cardiac surgery. Diastolic dysfunction is an independent predictor of PMI.

    DOI: 10.1253/circj.CJ-17-0747

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  • Impact of premature activation of the right ventricle with programmed stimulation in Brugada syndrome

    Koji Nakagawa, Satoshi Nagase, Hiroshi Morita, Tadashi Wada, Masamichi Tanaka, Masato Murakami, Atsuyuki Watanabe, Nobuhiro Nishii, Kazufumi Nakamura, Kengo F. Kusano, Hiroshi Ito, Tohru Ohe

    Journal of Cardiovascular Electrophysiology   29 ( 1 )   71 - 78   2018.1

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    DOI: 10.1111/jce.13336

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  • 顕性蛋白尿をきたした腎動脈狭窄症に対するPTRAの腎保護効果についての検討 Reviewed

    戸田 洋伸, 内田 治仁, 竹内 英実, 江尻 健太郎, 大塚 寛昭, 中川 晃志, 渡邊 敦之, 西井 伸洋, 三好 亨, 中村 一文, 森田 宏, 和田 淳, 伊藤 浩

    脈管学   57 ( Suppl. )   S138 - S138   2017.10

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  • 左冠動脈主幹部に起始異常を認め、その物理的圧迫による心筋虚血にて数年間にわたり失神を繰り返した若年者の1症例

    網岡 尚史, 渡邊 敦之, 大塚 寛昭, 赤木 達, 麻植 浩樹, 中川 晃志, 中村 一文, 森田 宏, 小谷 恭弘, 新井 禎彦, 笠原 真悟, 佐野 俊二, 伊藤 浩

    心臓   49 ( Suppl.1 )   110 - 110   2017.8

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  • 下肢動脈血栓塞栓症に対するEVTと外科的血栓除去の選択について Reviewed

    戸田 洋伸, 江尻 健太郎, 大澤 晋, 藤井 泰宏, 武本 梨佳, 内田 治仁, 中村 一文, 伊藤 浩

    脈管学   55 ( Suppl. )   S216 - S216   2015.10

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  • Pioglitazone prevents the endothelial dysfunction induced by ischemia and reperfusion in healthy subjects. International journal

    Yuka Sakatani, Toru Miyoshi, Hiroki Oe, Yoko Noda, Yuko Ohno, Kazufumi Nakamura, Yukihiro Saito, Kazuhiro Osawa, Hiroshi Morita, Kunihisa Kohno, Hiroshi Ito

    Journal of cardiovascular pharmacology   64 ( 4 )   326 - 31   2014.10

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    BACKGROUND: No study has investigated whether pioglitazone (an agonist of peroxisome proliferator-activated receptor gamma) protects against ischemia and reperfusion (IR)-induced endothelial dysfunction in humans. METHODS AND RESULTS: In the first crossover study, 20 volunteers were randomized to 1 week of pioglitazone (30 mg/d, postoperatively) or control (no treatment). In the second single-arm study, 15 volunteers received pioglitazone and the cyclooxygenase-2 inhibitor meloxicam for 1 week. On day 7, endothelium-dependent flow-mediated dilation (FMD) of the distal brachial artery was measured before and after IR (15 minutes of ischemia followed by 15 minutes of reperfusion in the proximal upper arm). Pre-IR brachial-artery diameter and FMD were similar across the 2 sessions (control, pioglitazone) in protocol 1 and between the 2 protocols. IR significantly blunted FMD after no treatment (pre-IR FMD: 10.2% ± 2.6%; post-IR FMD: 3.5% ± 1.9%, P < 0.01) but not after pioglitazone administration (pre-IR FMD: 9.7% ± 2.5%; post-IR FMD: 8.8% ± 2.9%, P = 0.11). This protective effect was accompanied by an increase in serum levels of the antioxidant enzyme extracellular superoxide dismutase and was not affected by concomitant administration of the cyclooxygenase-2 inhibitor meloxicam (P = 0.10). CONCLUSIONS: In humans, pioglitazone provides potent protection against IR-induced endothelial dysfunction.

    DOI: 10.1097/FJC.0000000000000124

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  • A successful epicardial ablation from the middle cardiac vein for ventricular tachycardia with prior inferior myocardial infarction

    Wada Tadashi, Nagase Satoshi, Tanaka Masamichi, Nakagawa Koji, Nishii Hironobu, Kohno Yoshihisa, Nakamura Kazufumi, Morita Hiroshi, Ito Hiroshi

    Shinzo   46 ( 3 )   S3_203 - S3_211   2014

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    DOI: 10.11281/shinzo.46.S3_203

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  • An unsuccessful case of PAH-specific therapy in patient with pulmonary hypertension associated with ventricular septal defect

    Akagi Satoshi, Sarashina Toshihiro, Kusano Kengo, Suzuki Hideyuki, Nakamura Kazufumi, Ito Hiroshi

    Shinzo   46 ( 6 )   812 - 815   2014

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    DOI: 10.11281/shinzo.46.812

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    Other Link: http://search.jamas.or.jp/link/ui/2014260969

  • LQT1において血清カリウム値がQT間隔および不整脈イベントに及ぼす影響

    杉山 洋樹, 中村 一文, 森田 宏, 三浦 大志, 永瀬 聡, 河野 晋久, 草野 研吾, 大江 透, 伊藤 浩

    心電図   33 ( Suppl.4 )   S - 194   2013.9

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  • Serum cystatin C as a biomarker of cardiac diastolic dysfunction in patients with cardiac disease and preserved ejection fraction. Reviewed

    Nosaka K, Nakamura K, Kusano K, Toh N, Tada T, Miyoshi T, Doi M, Kohno K, Morita H, Ito H

    Congestive heart failure (Greenwich, Conn.)   19 ( 4 )   E35 - 9   2013.7

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  • Safety and Efficacy of a Bolus Injection of Landiolol Hydrochloride as a Premedication for Multidetector-Row Computed Tomography Coronary Angiography

    OSAWA Kazuhiro, MIYOSHI Toru, SATO Shuhei, AKAGI Noriaki, MORIMITSU Yusuke, NAKAMURA Kazufumi, KOHNO Kunihisa, KUSANO Kengo, KANAZAWA Susumu, ITO Hiroshi

    JAPANESE CIRCULATION JOURNAL   77 ( 1 )   146 - 152   2012.12

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    Background: We evaluated the safety and efficacy of a bolus injection of landiolol hydrochloride, an ultrashort-acting β1-selective antagonist, as an additional treatment after premedication with an oral β-blocker to reduce heart rate prior to multidetector-row computed tomography (MDCT) coronary angiography (CAG). Methods and Results: A total of 458 patients who underwent MDCT CAG were retrospectively enrolled. Image quality and hemodynamic parameters were compared in patients before and after approval of landiolol hydrochloride. If heart rate reduction was insufficient after premedication with an oral β-blocker, a bolus injection of landiolol hydrochloride (n=66) or other drugs (n=30) was used. The percentage of evaluable images per segment in patients after approval of landiolol (99.3%) was greater than that in patients before approval of landiolol (97.4%, P<0.01). Heart rates before scanning in patients receiving landiolol hydrochloride were similar to those receiving other drugs. Heart rate was significantly reduced approximately 5min after injection of landiolol hydrochloride and increased shortly. No decrease in systolic blood pressure or other adverse effects was observed. Conclusions: Bolus injection of landiolol hydrochloride sufficiently reduced heart rate without significantly reducing systolic blood pressure and produced a high percentage of evaluable images, suggesting that bolus injection of landiolol hydrochloride as an additional pretreatment is feasible in MDCT CAG.  (Circ J 2013; 77: 146–152)<br>

    DOI: 10.1253/circj.CJ-12-0663

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  • Guidelines for treatment of chronic heart failure

    124 ( 1 )   71 - 73   2012.4

  • Sustained monomorphic ventricular tachycardia in patients with Brugada syndrome

    Take Yutaka, Morita Hiroshi, Toh Norihisa, Nishii Nobuhiro, Hashimoto Katsushi, Nagase Satoshi, Nakamura Kazuhumi, Kohno Kunihisa, Kusano Kengo, Ohe Tohru, Ito Hiroshi

    Shinzo   44 ( 2 )   S2_55 - S2_55   2012

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  • Beta-Blockers and Oxidative Stress in Patients with Heart Failure. Reviewed International journal

    Nakamura K, Murakami M, Miura D, Yunoki K, Enko K, Tanaka M, Saito Y, Nishii N, Miyoshi T, Yoshida M, Oe H, Toh N, Nagase S, Kohno K, Morita H, Matsubara H, Kusano KF, Ohe T, Ito H

    Pharmaceuticals (Basel, Switzerland)   4 ( 8 )   1088 - 1100   2011.8

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    Oxidative stress has been implicated in the pathogenesis of heart failure. Reactive oxygen species (ROS) are produced in the failing myocardium, and ROS cause hypertrophy, apoptosis/cell death and intracellular Ca(2+) overload in cardiac myocytes. ROS also cause damage to lipid cell membranes in the process of lipid peroxidation. In this process, several aldehydes, including 4-hydroxy-2-nonenal (HNE), are generated and the amount of HNE is increased in the human failing myocardium. HNE exacerbates the formation of ROS, especially H₂O₂ and ·OH, in cardiomyocytes and subsequently ROS cause intracellular Ca(2+) overload. Treatment with beta-blockers such as metoprolol, carvedilol and bisoprolol reduces the levels of oxidative stress, together with amelioration of heart failure. This reduction could be caused by several possible mechanisms. First, the beta-blocking effect is important, because catecholamines such as isoproterenol and norepinephrine induce oxidative stress in the myocardium. Second, anti-ischemic effects and negative chronotropic effects are also important. Furthermore, direct antioxidative effects of carvedilol contribute to the reduction of oxidative stress. Carvedilol inhibited HNE-induced intracellular Ca(2+) overload. Beta-blocker therapy is a useful antioxidative therapy in patients with heart failure.

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  • 糖尿病と心血管疾患 拡張不全における糖代謝異常の関与

    中村 一文, 三好 亨, 三浦 大志, 麻植 浩樹, 伊藤 浩

    日本心臓病学会誌   6 ( Suppl.I )   167 - 167   2011.8

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  • Indication of implantable cardioverter defibrillator for myotonic dystrophy in patients with high degree atrio-ventricular block

    Take Yutaka, Morita Hiroshi, Nishii Nobuhiro, Nagase Satoshi, Kazufumi Nakamura, Kohno Kunihisa, Kusano Kengo, Ito Hiroshi

    Shinzo   43 ( 2 )   S2_39 - S2_45   2011

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    DOI: 10.11281/shinzo.43.S2_39

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  • Anti-tachycardia pacing degenerated fast ventricular tachycardia into undetectable life-threatening tachyarrhythmia in a patient with non-ischemic dilated cardiomyopathy.

    Kei Yunoki, Nobuhiro Nishii, Hiroshi Morita, Jun Iwasaki, Satoshi Nagase, Kazufumi Nakamura, Yoshiki Hata, Kunihisa Kohno, Kengo F Kusano, Hiroshi Ito

    Journal of cardiology cases   2 ( 3 )   e159-e162   2010.12

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    A 45-year-old man with dilated cardiomyopathy was admitted to our hospital due to congestive heart failure (CHF). Despite the optimal medical treatment, his condition had not improved because of severe left ventricular dysfunction. Because he experienced non-sustained ventricular tachycardia (VT), a biventricular implantable cardioverter-defibrillator (Bi-V ICD) was implanted for reduction of dyssynchrony and primary prevention of lethal tachyarrhythmia. After discharge, he developed CHF and was transported to our hospital by ambulance. In the ambulance, monomorphic sustained VT with 200 bpm suddenly occurred. The ICD detected it as fast VT and anti-tachycardia pacing (ATP) was delivered. After the ATP therapy, RR intervals of VT became irregular and prolonged. Ventricular fibrillation-like electrical activity was recorded by a far-field electrogram from the defibrillator, but the tachycardia cycle length exceeded 400 ms which is under the tachycardia detection rate. The device failed to deliver a shock and the patient had to be rescued with an external shock. This is a rare case of fast VT that degenerated into undetectable life-threatening tachyarrhythmia by ATP.

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  • Brugada症候群における酸化ストレスと心室細動発症の関連

    田中 正道, 中村 一文, 大郷 恵子, 三浦 大志, 三浦 綾, 西井 伸洋, 永瀬 聡, 幡 芳樹, 森田 宏, 草野 研吾, 大江 透, 伊藤 浩, 由谷 親夫

    心臓   42 ( 10 )   1369 - 1369   2010.10

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  • 免疫と不整脈 K+チャネル自己抗体による後天性QT延長症候群 自己免疫性QT延長症候群

    中村 一文, 杉山 洋樹, 三浦 大志, 森田 宏, 草野 研吾, 伊藤 浩, 片山 祐介, 大江 透

    心電図   30 ( Suppl.3 )   S - 28   2010.7

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  • Abnormal restitution property of action potential duration and conduction delay in Brugada syndrome: both repolarization and depolarization abnormalities. International journal

    Nobuhiro Nishii, Satoshi Nagase, Hiroshi Morita, Kengo Fukushima Kusano, Tsunetoyo Namba, Daiji Miura, Kohei Miyaji, Shigeki Hiramatsu, Takeshi Tada, Masato Murakami, Atsuyuki Watanabe, Kimikazu Banba, Yoshiaki Sakai, Kazufumi Nakamura, Takefumi Oka, Tohru Ohe

    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology   12 ( 4 )   544 - 52   2010.4

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    AIMS: This study sought to examine the action potential duration restitution (APDR) property and conduction delay in Brugada syndrome (BrS) patients. A steeply sloped APDR curve and conduction delay are known to be important determinants for the occurrence of ventricular fibrillation (VF). METHODS AND RESULTS: Endocardial monophasic action potential was obtained from 39 BrS patients and 9 control subjects using the contact electrode method. Maximum slopes of the APDR curve were obtained at both the right ventricular outflow tract (RVOT) and the right ventricular apex (RVA). The onset of activation delay (OAD) after premature stimulation was examined as a marker of conduction delay. Maximum slope of the APDR curve in BrS patients was significantly steeper than that in control subjects at both the RVOT and the RVA (0.77 +/- 0.21 vs. 058 +/- 0.14 at RVOT, P = 0.009; 0.98 +/- 0.23 vs. 0.62 +/- 0.16 at RVA, P = 0.001). The dispersion of maximum slope of the APDR curve between the RVOT and the RVA was also larger in BrS patients than in control subjects. The OAD was significantly longer in BrS patients than in control subjects from the RVOT to RVA and from the RVA to RVOT (from RVOT to RVA: 256 +/- 12 vs. 243 +/- 7 ms, P = 0.003; from RVA to RVOT: 252 +/- 11 vs. 241 +/- 9 ms, P = 0.01). CONCLUSIONS: Abnormal APDR properties and conduction delay were observed in BrS patients. Both repolarization and depolarization abnormalities are thought to be related to the development of VF in BrS patients.

    DOI: 10.1093/europace/eup432

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  • マイクロ空間構造付き細胞培養ディッシュを用いた新規マイグレーションアッセイ法の開発

    西 泰治, 三浦 大志, 中村 一文, 浦川 茂美, 赤木 達, 三浦 綾, 草野 研吾, 大江 透, 菊池 佑二

    日本ヘモレオロジー学会プログラム・抄録集   16回   41 - 41   2009.11

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  • 特発性2方向性心室頻拍の臨床電気生理学的機序の検討

    杉山 洋樹, 森田 宏, 三浦 大志, 永瀬 聡, 中村 一文, 岡 岳文, 草野 研吾, 大江 透

    心電図   28 ( 5 )   480 - 480   2008.10

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  • Brugada症候群患者における心室性不整脈の発生とSCN5A変異の関連

    森田 宏, 三浦 大志, 中村 一文, 永瀬 聡, 草野 研吾, 大江 透

    心電図   28 ( 5 )   484 - 484   2008.10

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  • Brugada症候群におけるICD作動の予測因子

    西井 伸洋, 森田 宏, 平松 茂樹, 多田 毅, 村上 正人, 三浦 大志, 永瀬 聡, 中村 一文, 岡 岳文, 大江 透, 草野 研吾

    心電図   28 ( 5 )   489 - 489   2008.10

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  • 精巣摘出によりBrugada型心電図が消失した心筋ナトリウムチャネル遺伝子変異を有する1症例

    森田 宏, 草野 研吾, 永瀬 聡, 三浦 大志, 中村 一文, 大江 透

    Journal of Arrhythmia   24 ( Suppl. )   185 - 185   2008.4

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  • イオンチャネル病のUp-to-date Anderson-Tawil症候群の心電図異常および不整脈発生の機序の検討

    森田 宏, 谷 義則, 永瀬 聡, 三浦 大志, 杉山 洋樹, 中村 一文, 草野 研吾, 大江 透, ザイペス・ダグラス, 古川 哲史

    Journal of Arrhythmia   24 ( Suppl. )   98 - 98   2008.4

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  • スプライシング供与部位に接する配列に変異を認めたQT延長症候群の一家系

    赤木 達, 中村 一文, 福家 聡一郎, 三浦 大志, 永瀬 聡, 桜木 悟, 草野 研吾, 大江 透, 末丸 俊二

    Journal of Arrhythmia   23 ( Suppl. )   304 - 304   2007.4

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  • Brugada症候群におけるNa遮断薬投与前後の体表面心電図と加算平均心電図の検討 SCN5A遺伝子での検討

    渡辺 敦之, 草野 研吾, 永瀬 聡, 三浦 大志, 平松 茂樹, 伴場 主一, 西井 伸洋, 中村 一文, 桜木 悟, 酒井 芳明, 大江 透

    心臓   39 ( Suppl.1 )   62 - 62   2007.2

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  • SCN5A遺伝子のスプライシングドナーサイトに新規のmutationを認めたBrugada症候群の1例

    三浦 大志, 中村 一文, 三浦 綾, 平松 茂樹, 渡邊 敦之, 西井 伸洋, 伴場 主一, 谷山 真規子, 木村 英夫, 岩崎 淳, 浦川 茂美, 角田 和歌子, 湯本 晃久, 河野 康之, 永瀬 聡, 櫻木 悟, 草野 研吾, 大江 透

    心電図   26 ( 4 )   500 - 500   2006.6

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  • イオンチャネル異常による致死性不整脈 Brugada症候群におけるSCN5A遺伝子変異の臨床的意義

    伴場 主一, 永瀬 聡, 三浦 大志, 平松 茂樹, 西井 伸洋, 渡辺 敦之, 中村 一文, 櫻木 悟, 酒井 芳昭, 草野 研吾, 大江 透

    心電図   26 ( 4 )   408 - 408   2006.6

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  • Andersen症候群の母子における各種薬剤負荷による心電図学的検討

    永瀬 聡, 西井 伸洋, 伴場 主一, 渡辺 敦之, 平松 茂樹, 酒井 芳昭, 三浦 大志, 三浦 綾, 中村 一文, 桜木 悟, 草野 研吾, 大江 透

    心電図   26 ( 4 )   485 - 485   2006.6

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  • SCN5A遺伝子のスプライシングドナーサイトに新規のmutationを認めたBrugada症候群の1例

    三浦 大志, 中村 一文, 三浦 綾, 平松 茂樹, 渡邊 敦之, 西井 伸洋, 伴場 主一, 谷山 真規子, 木村 英夫, 岩崎 淳, 浦川 茂美, 角田 和歌子, 湯本 晃久, 河野 康之, 永瀬 聡, 櫻木 悟, 草野 研吾, 大江 透

    Journal of Arrhythmia   22 ( Suppl. )   244 - 244   2006.5

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  • イオンチャネル異常による致死性不整脈 Brugada症候群におけるSCN5A遺伝子変異の臨床的意義

    伴場 主一, 永瀬 聡, 三浦 大志, 平松 茂樹, 西井 伸洋, 渡辺 敦之, 中村 一文, 桜木 悟, 酒井 芳昭, 草野 研吾, 大江 透

    Journal of Arrhythmia   22 ( Suppl. )   152 - 152   2006.5

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  • Andersen症候群の母子における各種薬剤負荷による心電図学的検討

    永瀬 聡, 西井 伸洋, 伴場 主一, 渡辺 敦之, 平松 茂樹, 酒井 芳昭, 三浦 大志, 三浦 綾, 中村 一文, 桜木 悟, 草野 研吾, 大江 透

    Journal of Arrhythmia   22 ( Suppl. )   229 - 229   2006.5

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  • [Long QT syndrome].

    Atsuyuki Watanabe, Kazufumi Nakamura, Hiroshi Morita, Kengo Fukushima Kusano, Tohru Ohe

    Nihon rinsho. Japanese journal of clinical medicine   63 ( 7 )   1171 - 7   2005.7

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    The long QT syndrome (LQTS) is characterized by prolongation of the QT interval, causing torsade de pointes and sudden cardiac death. This syndrome can be divided into idiopathic (congenital) and acquired forms. The idiopathic form is a familial disorder that can be associated with sensorineural deafness (Jervell and Lange--Nielsen syndrome, autosomal recessive) or normal hearing (Romano--Ward syndrome, autosomal dominant). The acquired form has a long QT interval caused by various drugs such as quinidine sotalol and dofetilide, also by noncardiovascular drugs such as antihistamine, antibiotics, antipsychotics and others. Also, the QT interval is prolonged by electrolyte abnormalities such as hypokalemia and hypomagnesemia, central nervous system lesions, significant bradyarrhythmias, cardiac ganglionitis, mitral valve prolapse and probucol. DNA variants appearing to predispose to drug-associated acquired long QT syndrome have been reported in congenital long QT.

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  • カルシウム拮抗薬(CCB)の抗炎症作用についての検討

    三浦 龍志, 中村 一文, 三浦 大志, 三浦 綾, 久松 研一, 橋本 克史, 永瀬 聡, 森田 宏, 草野 研吾, 齋藤 博則, 江森 哲郎, 大江 透

    Circulation Journal   69 ( Suppl.II )   805 - 805   2005.4

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  • SCN5A遺伝子異常(R282H)を認めたBrugada症候群の一家系

    中村 一文, 三浦 大志, 平松 茂樹, 湯本 晃久, 江森 哲郎, 森田 宏, 渡辺 敦之, 永瀬 聡, 齋藤 博則, 草野 研吾, 西井 伸洋, 大江 透, 長野 仁, 神山 憲王

    Circulation Journal   69 ( Suppl.II )   798 - 798   2005.4

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  • Relationships between depolarization abnormality and repolarization abnormality in patients with Brugada syndrome: using body surface signal-averaged electrocardiography and body surface maps. International journal

    Kenichi Hisamatsu, Kengo Fukushima Kusano, Hiroshi Morita, Shiho Takenaka, Satoshi Nagase, Kazufumi Nakamura, Tetsuro Emori, Hiromi Matsubara, Hiroshi Mikouchi, Yoshitomo Nishizaki, Tohru Ohe

    Journal of cardiovascular electrophysiology   15 ( 8 )   870 - 6   2004.8

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    INTRODUCTION: Repolarization and depolarization abnormalities have been reported to be related to Brugada syndrome. METHODS AND RESULTS: We evaluated the relationships between repolarization abnormality and depolarization abnormality using 48-lead unipolar signal-averaged electrocardiograms and 87-lead unipolar body surface maps in 15 patients with Brugada-type ECGs. Data were compared with those from healthy control subjects (n = 5) and within subgroups of Brugada syndrome with (n = 8) and without (n = 7) ventricular arrhythmias (VA) induced by programmed electrical stimulation (PES). Eighty-seven-lead body surface maps were recorded, and potential maps were constructed to evaluate elevation of the ST segment 20 ms after the J point. Forty-eight-lead signal-averaged ECGs were recorded, and isochronal maps of duration of the delayed potential (dDP) were constructed to evaluate the dDP in each lead. Potential maps showed that patients with Brugada-type ECG, especially those with VA induced by programmed electrical stimulation, had greater elevation of the ST segment in the right ventricular outflow tract, especially at E5. Isochronal maps of dDP in the Brugada-type ECG group showed that maximum dDP was located at E5 and that the area with long dDP was larger than that in the control subjects. The dDPs at E7, E5, F7, and F5 in the VA-inducible group were significantly longer than those in the VA-noninducible group. These results showed that the location of greater elevation in the ST segment coincided with the location of longer dDP. CONCLUSION: Repolarization abnormality and depolarization abnormality in the walls of both ventricles, especially in the right ventricular outflow tract, are related to the VA of Brugada syndrome.

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  • Evaluation of the usefulness of recording the ECG in the 3rd intercostal space and prevalence of Brugada-type ECG in accordance with recently established electrocardiographic criteria.

    Kenichi Hisamatsu, Hiroshi Morita, Kengo Fukushima Kusano, Shiho Takenaka, Satoshi Nagase, Kazufumi Nakamura, Tetsuro Emori, Tohru Ohe

    Circulation journal : official journal of the Japanese Circulation Society   68 ( 2 )   135 - 8   2004.2

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    BACKGROUND: It has been reported that recording electrocardiograms (ECGs) in the 3rd intercostal space (ICS) is one method that can be used for detecting Brugada syndrome; however, the prevalence of Brugada-type ECGs recorded in the 3rd ICS and the usefulness of recording the ECG in the 3rd ICS in accordance with recently established electrocardiographic criteria is unknown. METHODS AND RESULTS: ECGs were recorded in both the 4th and 3rd ICS in 17 Brugada-type ECG patients (group A) and in 206 consecutive male subjects (group B). Brugada-type ECGs were divided into 3 types. In group A, the prevalence of type 1 ECG, which is a coved-type ECG with ST-segment elevation of >/=2 mm, increased from 23.5% to 64.7% when ECG was recorded in the 3rd ICS. The conversion to type 1 ECG was found to be related to induction of ventricular arrhythmia. In group B, the prevalence of Brugada-type ECG increased from 1.5% to 5.8% when the ECG was recorded in the 3rd ICS. CONCLUSIONS: Recording the ECG in the 3rd ICS is useful for identifying high-risk patients with Brugada-type ECG and for detecting concealed Brugada-type ECG.

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  • Risk stratification for asymptomatic patients with Brugada syndrome.

    Hiroshi Morita, Shiho Takenaka-Morita, Kengo Fukushima-Kusano, Makoto Kobayashi, Satoshi Nagase, Mikio Kakishita, Kazufumi Nakamura, Tetsuro Emori, Hiromi Matsubara, Tohru Ohe

    Circulation journal : official journal of the Japanese Circulation Society   67 ( 4 )   312 - 6   2003.4

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    Ventricular fibrillation (VF) is induced in some asymptomatic patients with Brugada syndrome (BS), but the prognostic value of programmed electrical stimulation (PES) in such patients is controversial. The clinical characteristics of 41 asymptomatic BS patients, divided into 2 groups according to whether VF was induced by PES (inducible VF group: n=13, non-inducible VF group: n=28) were evaluated. ST levels in the right precordial leads were measured before and after administration of pilsicainide and the abnormal late potential (LP) was evaluated on the signal-averaged electrogram. The ST level at V(2) at baseline in the inducible VF group was significantly higher than that in the non-inducible VF group (p<0.05). Pilsicainide induced significant ST segment elevation in both groups and the ST level after pilsicainide in the inducible VF group was higher than that in the non-inducible VF group (p<0.01). LP was more frequent in the inducible VF group than in the non-inducible VF group. The criterion of ST level >0.15 mV at baseline with pilsicainide-induced additional ST elevation >0.10 mV and positive LP showed high sensitivity (92%) and specificity (89%) for detection of PES-induced VF in asymptomatic BS patients.

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  • Clinical outcomes of patients with isolated cardiac sarcoidosis confirmed by clinical diagnostic criteria.

    Takaya Y Nakamura K Nishii N , Ito H

    Int J Cardiol   345   49 - 53   2021.12

  • Efficacy of shear wave elasticity for evaluating myocardial hypertrophy in hypertensive rats.

    Takaya Y Nakamura K Nakayama R Ohtsuka H Amioka N Kondo M Akazawa K Ohno Y IchikawanK Saito Y , Akagi S , Yoshida M , Miyoshi T , Ito H

    Sci Rep   11 ( 1 )   22812   2021.11

  • Preventative effects of bisoprolol transdermal patches on postoperative atrial fibrillation in high-risk patients undergoing non-cardiac surgery: A subanalysis of the MAMACARI study.

    Iwano T, Toda H, Nakamura K, Shimizu K, Ejiri K, Naito Y, Mori H, Masuda T, Miyoshi T, Yoshida M, Hikasa Y, Morimatsu H, Ito H, Investigators M.

    J Cardiol   78 ( 5 )   349 - 354   2021.11

  • Predictive Value of the Cardio-Ankle Vascular Index for Cardiovascular Events in Patients at Cardiovascular Risk.

    Miyoshi T, Ito H, Shirai K, Horinaka S, Higaki J, Yamamura S, Saiki A, Takahashi M, Masaki M, Okura T, Kotani K, Kubozono T, Yoshioka R, Kihara H, Hasagawa M, Satoh-Asahara N, Orimi H, C-Ji.

    J Am Heart Assoc   10 ( 16 )   e020103   2021.8

  • Diagnosis of wild-type transthyretin amyloid cardiomyopathy in Japan: red-flag symptom clusters and diagnostic algorithm.

    Inomata T, Tahara N, Nakamura K, Endo J, Ueda M, Ishii T, Kitano Y, Koyama J.

    ESC Hear Fail   8 ( 4 )   2647 - 2659   2021.8

  • Pathological and clinical effects of interleukin-6 on human myocarditis.

    Amioka N, Nakamura K, Kimura T, Ohta-Ogo K, Tanaka T, Toji T, Akagi S, Nakagawa K, Toh N, Yoshida M, Miyoshi T, Nishii N, Watanabe A, Asano R, Ogo T, Nakaoka Y, Morita H, Yanai H, Ito H.

    J Cardiol   78 ( 2 )   157 - 165   2021.8

  • Heart Failure Association,Heart Failure Society of America, and Japanese Heart Failure Society Position Statement on Endomyocardial Biopsy.

    Seferovic PM, Tsutsui H, McNamara DM, Ristic AD, Basso C, Bozkuet B, Cooper LT, Filippatos G, Ide , Inomata T, Nakamura K, Anker SD, Veljic I, Ohtani T, Okumura T, Thum T, Tschope C, Rosano G, Coats AJS, Starling RC

    J Card Fail   27 ( 7 )   727 - 743   2021.7

  • Inhibitory effects of RAGE-aptamer on development of monocrotaline-induced pulmonary arterial hypertension in rats.

    Nakamura K, Akagi S, Ejiri K, Yoshida M, Miyoshi T, Sakaguchi M, Amioka N, Suastika LOS, Kondo M, Nakayama R, Takaya Y, Higashimoto Y, Fukami K, Matsubara H, Ito H.

    J Cardiol   78 ( 1 )   12 - 16   2021.7

  • Efficacy of shear wave elastography for evaluating right ventricular myocardial fibrosis in monocrotaline-induced pulmonary hypertention rats.

    Nakayama R, Takaya Y, Nakamura K, Kondo M, Kobayashi K, Ohno Y, Amioka N, Akagi S, Yoshida M, Miyoshi T, Ito H.

    J Cardiol   78 ( 1 )   17 - 23   2021.7

  • Heart Failure Association of the ESC, Heart Failure Society of America and Japanese Heart Failure Society Position statement on endomyocardial biopsy.

    Seferovic PM, Tsutsui H, McNamara DM, Ristic AD, Basso C, Bozkuet B, Cooper LT, Jr.,Filippatos G, Ide T , Inomata T,Klingel K, Linhart A, Lyon AR, Mehra MR, Polovina M,Milinkovic I, Nakamura K, Anker SD, Veljic I, Ohtani T, Okumura T, Thum T, Tschope C, Rosano G, Coats AJS, Starling RC

    Eur J Heart Fail   23 ( 6 )   854 - 871   2021.6

  • Efficacy and Safety of Early Intravenous Landiolol on Myocardial Salvage in Patients with ST-segment Elevation Myocardial Infarction before Primary Percutaneous Coronary Intervention: A Randomized Study.

    Miyamoto M, Osawa K, Miyoshi T, Mori A, Yoshikawa M, Oka T, Ichikawa K, Nakamura K, Ito H.

    Acra Med Okayama   75 ( 3 )   289 - 297   2021.6

  • Efficacy of shear wave elastography for assessment of liverb function in patients with heart failure.

    Nakayama R, Takaya Y, Nakamura K, Toh N, Ito H.

    ESC Heart Fail.   8 ( 3 )   1751 - 1758   2021.6

  • Prognosis of patients with severe left ventricular dysfunction after transvenous lead extraction and the need for additional hemodynamic support in the perioperative period.

    Nishii N, Nishimoto T, Mizuno T, Masuda T, Asada S, Miyamoto M, Kawada S, Nakagawa K, Nakamura K, Morita H, Morimatsu H, Kasahara S, Ito H.

    Heart Rhythm.   18 ( 6 )   962 - 969   2021.6

  • usefulness of right ventriculography compared with computed tomography for ruling out the possibility of lead perforation before lead extraction.

    Asada S, Nishii N, Shinya T, Miyoshi A, Morimoto Y, Miyamoto M, Nakagawa K, Nakamura K, Morita H, Ito H.

    PLoS One   16 ( 3 )   e0245502   2021.3

  • Higher oxidized high-density lipoprotein to apolipoprotein A-I ratio is associated with high-risk coronary plaque characteristics determined by CT angiography.

    Suruga K , Miyoshi T , Kotani K, Ichikawa K , Mki T , Osawa K , Ejiei K , Toda H , Nakamura K , Morita H , Ito H

    Int J Cardiol   324   193 - 198   2021.2

  • Possible Protective Effect of Remote Ischemic Preconditioning on Acute Kidney Injury Following Elective Percutaneous Coronary Intervention: Secondary Analysis of a Multicenter,Randomized Study.

    Otsuka H, Miyoshi T, Ejiri K, Kohno K, Nakahama M, Doi M, Munemasa M, Murakami M, Nakamura K, Ito H.

    Acta Med Okayama   75 ( 1 )   45 - 53   2021.2

  • Effects of Dual Initial Combination Therapy With Macitentan Plus Riociguat or Macitentan Plus Selexipag on Hemodynamics in Patients With Pulmonary Arterial Hypertension (SETOUCHI-PH Study)-Protocol of a Multicenter Randomized Control Trial.

    Akagi S, Dohi Y, Ishikawa K, Kubota K, Horimoto K, Yagi S, Hirata T, Yamamoto E, ito H, Nakamura K.

    Circ Rep   3 ( 2 )   105 - 109   2021.1

  • Prognostic value of non-alcoholic fatty liver disease for predicting cardiovascular events in patients with diabetes mellitus with suspected coronary artery disease: a prospective cohort study.

    Ichikawa K, Miyoshi T, Osawa K, Miki T, Toda H, Ejiri K, Yoshida M, Nanba Y, Yoshida M, Nakamura K, Morita H, Ito H.

    Cardiovasc Diabetol   20 ( 1 )   8   2021.1

  • Electron Microscopy Revealed Massive Lipid Droplets in Cardiomyocytes in a Patient with Cardiogenic Shock Following a Fulminant Type 1 Diabetes Mellitus.

    Sugawara R , Sugiyama H , Nakamura K , Tohgi K , Hongo T, Tsuchiya M , Momoki N , Nose S , Yutani C , Ikeda T, Ito H

    Int Heart J   62 ( 1 )   197 - 200   2021.1

  • Medical and surgical management of a pulmonary hypertensive adult patient with unrepaired complex congenital heart disease: a case report.

    Akagi S Kasahara S Akagi T Nakamura K Ito H

    Journal of Congenital Cardiology.   4 ( 1 )   2   2020.1

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Books

  • そうだったんだ!脂質異常症 第2版

    中村一文( Role: Contributor ,  糖尿病性心筋症)

    文光堂  2020.3 

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    Responsible for pages:146-149   Language:Japanese Book type:Scholarly book

  • 肺高血圧症診療ハンドブック

    中村一文、赤木 達( Role: Contributor ,  肺動脈性肺高血圧症(PAH)における肺血管のリバースリモデリング)

    中外医学社  2020.1 

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    Responsible for pages:77-81   Language:Japanese Book type:Scholarly book

  • 新 肺高血圧症診療マニュアル-根治を目指す最新の治療指針

    南江堂  2017 

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  • 心血管事故を予防するための糖尿病治療戦略 実践のためのQ&A

    文光堂  2016 

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  • 右心不全を識り評価して治療に活かす

    文光堂  2016 

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  • 右心不全を識り評価して治療に活かす

    文光堂  2016 

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  • 循環器内科グリーンノート

    中外医学社  2016 

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  • 心血管事故を予防するための糖尿病治療戦略 実践のためのQ&A

    文光堂  2016 

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  • 実はすごい!ACE阻害薬―エキスパートからのアドバイス50

    南江堂  2015 

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  • 拡張不全の日常診療Q&A

    中学医学社  2015 

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  • 拡張不全の日常診療Q&A

    中学医学社  2015 

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  • 最新医学 別冊心不全 診断と治療のABC

    最新医学社  2015 

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  • 循環器疾患の最新の治療

    南江堂  2010 

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  • β遮断薬のすべて 第3版(共著)

    先端医学社  2009 

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  • 遺伝子型と表現型との関連

    メジカルビュー社  2009 

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  • 第36回かなえ医薬振興財団助成金受賞者研究業績集

    財団法人 かなえ医薬振興財団  2009 

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  • 第38回「医学研究助成」研究報告集

    2007 

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  • 財)中谷電子計測技術振興財団 年報

    2007 

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MISC

  • 肺循環の生理と肺動脈性肺高血圧症の病態生理からみたその治療

    中村一文, 赤木達, 岩野貴之, 江尻健太郎, 杜徳尚, 伊藤浩, 清水一好, 岩崎達雄

    Cardiovascular Anesthesia   25 ( 1 )   2021

  • Initial experience with the subcutaneous implantable cardioverter-defibrillator in a single Japanese center

    Nobuhiro Nishii, Motomi Tachibana, Yoshimasa Morimoto, Satoshi Kawada, Akihito Miyoshi, Hiroyasu Sugiyama, Koji Nakagawa, Atsuyuki Watanabe, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Ito

    Journal of Arrhythmia   33 ( 4 )   338 - 341   2017.8

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    Language:English   Publisher:Elsevier B.V.  

    Background The subcutaneous implantable cardioverter-defibrillator (S-ICD) is recognized as a viable alternative to the transvenous ICD. The safety and efficacy of this device has been demonstrated in Western countries, but studies with S-ICD implantation in Japanese patients have not been reported. Methods and results Twelve patients received an S-ICD implant in our institute between February and September 2016. All S-ICDs were successfully implanted without complications. One appropriate and one inappropriate therapy was identified. Conclusions S-ICD implantation appears to provide a viable alternative to transvenous ICD implantation for some Japanese patients. However, we should perform careful follow-up of patients to eliminate inappropriate therapy.

    DOI: 10.1016/j.joa.2017.02.004

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  • Eicosapentaenoic acid prevents arterial calcification in klotho mutant mice

    Kazufumi Nakamura, Daiji Miura, Yukihiro Saito, Kei Yunoki, Yasushi Koyama, Minoru Satoh, Megumi Kondo, Kazuhiro Osawa, Omer F. Hatipoglu, Toru Miyoshi, Masashi Yoshida, Hiroshi Morita, Hiroshi Ito

    PLOS ONE   12 ( 8 )   159 - 166   2017.8

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    Language:English   Publisher:PUBLIC LIBRARY SCIENCE  

    Background
    The klotho gene was identified as an "aging-suppressor" gene that accelerates arterial calcification when disrupted. Serum and vascular klotho levels are reduced in patients with chronic kidney disease, and the reduced levels are associated with arterial calcification. Intake of eicosapentaenoic acid (EPA), an n-3 fatty acid, reduces the risk of fatal coronary artery disease. However, the effects of EPA on arterial calcification have not been fully elucidated. The aim of this study was to determine the effect of EPA on arterial calcification in klotho mutant mice.
    Methods and results
    Four-week-old klotho mutant mice and wild-type (WT) mice were given a diet containing 5% EPA (EPA food, klotho and WT: n = 12, each) or not containing EPA (control food, klotho and WT: n = 12, each) for 4 weeks. Calcium volume scores of thoracic and abdominal aortas assessed by computed tomography were significantly elevated in klotho mice after 4 weeks of control food, but they were not elevated in klotho mice after EPA food or in WT mice. Serum levels of EPA and resolvin E1, an active metabolite of EPA, in EPA food-fed mice were significantly increased compared to those in control food-fed mice. An oxidative stress PCR array followed by quantitative PCR revealed that NADPH oxidase-4 (NOX4), an enzyme that generates superoxide, gene expression was up-regulated in arterial smooth muscle cells (SMCs) of klotho mice. Activity of NOX was also significantly higher in SMCs of klotho mice than in those of WT mice. EPA decreased expression levels of the NOX4 gene and NOX activity. GPR120, a receptor of n-3 fatty acids, gene knockdown by siRNA canceled effects of EPA on NOX4 gene expression and NOX activity in arterial SMCs of klotho mice.
    Conclusions
    EPA prevents arterial calcification together with reduction of NOX gene expression and activity via GPR120 in klotho mutant mice.

    DOI: 10.1371/journal.pone.0181009

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  • Suppression of Wnt Signaling and Osteogenic Changes in Vascular Smooth Muscle Cells by Eicosapentaenoic Acid

    Yukihiro Saito, Kazufumi Nakamura, Daiji Miura, Kei Yunoki, Toru Miyoshi, Masashi Yoshida, Norifumi Kawakita, Tomonari Kimura, Megumi Kondo, Toshihiro Sarashina, Satoshi Akagi, Atsuyuki Watanabe, Nobuhiro Nishii, Hiroshi Morita, Hiroshi Ito

    NUTRIENTS   9 ( 8 )   17574 - 17582   2017.8

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    Vascular medial calcification is often observed in patients with arteriosclerosis. It is also associated with systolic hypertension, wide pulse pressure, and fluctuation of blood pressure, which results in cardiovascular events. Eicosapentaenoic acid (EPA) has been shown to suppress vascular calcification in previous animal experiments. We investigated the inhibitory effects of EPA on Wnt signaling, which is one of the important signaling pathways involved in vascular calcification. Intake of food containing 5% EPA resulted in upregulation of the mRNA expression of Klotho, an intrinsic inhibitor of Wnt signaling, in the kidneys of wild-type mice. Expression levels of beta-catenin, an intracellular signal transducer in the Wnt signaling pathway, were increased in the aortas of Klotho mutant (kl/kl) mice compared to the levels in the aortas of wild-type mice. Wnt3a or BIO, a GSK-3 inhibitor that activates beta-catenin signaling, upregulated mRNA levels of AXIN2 and LEF1, Wnt signaling marker genes, and RUNX2 and BMP4, early osteogenic genes, in human aorta smooth muscle cells. EPA suppressed the upregulation of AXIN2 and BMP4. The effect of EPA was cancelled by T0070907, a PPAR gamma inhibitor. The results suggested that EPA could suppress vascular calcification via the inhibition of Wnt signaling in osteogenic vascular smooth muscle cells via PPAR gamma activation.

    DOI: 10.3390/nu9080858

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  • Early and frequent defibrillator discharge in patients with cardiac sarcoidosis compared with patients with idiopathic dilated cardiomyopathy

    Yoichi Takaya, Kengo Kusano, Nobuhiro Nishii, Kazufumi Nakamura, Hiroshi Ito

    INTERNATIONAL JOURNAL OF CARDIOLOGY   240   302 - 306   2017.8

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    Background: Little is known about the suitability of implantable cardioverter defibrillator (ICD) implantation in patients with cardiac sarcoidosis (CS). We evaluated the efficacy of ICD implantation in patients with CS, including suspected CS, compared with those with idiopathic dilated cardiomyopathy (DCM).
    Methods: A total of 102 consecutive patients with definite CS, suspected CS, or DCM who underwent ICD implantation were enrolled. The endpoint was the first documentation of appropriate ICD therapy for ventricular tachyarrhythmias. The follow-up started after ICD implantation.
    Results: Appropriate ICD therapies occurred in 15 (56%) of 27 patients with definite CS, 17 (68%) of 25 with suspected CS, and 16 (32%) of 50 with DCM. The rate of appropriate ICD therapies was higher in patients with definite CS and those with suspected CS than in those with DCM (log-rank test, p= 0.010). After ICD implantation, five or more appropriate ICD therapies occurred in 5 (19%) patients with definite CS and 10 (40%) with suspected CS, but in only 1 (2%) with DCM. Cox proportional hazard analysis showed that CS, including suspected CS, was independently associated with appropriate ICD therapies. For primary prevention, the rate of appropriate ICD therapies was higher in patients with CS than in those with DCM(log-rank test, p= 0.034). More than half of patients with CS received appropriate ICD therapies.
    Conclusions: Patients with CS receive appropriate ICD therapies for ventricular tachyarrhythmias at a higher rate, compared with those with DCM, suggesting that ICD implantation should be performed in patients with CS.

    DOI: 10.1016/j.ijcard.2017.04.044

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  • High Frequency of Acute Adverse Cardiovascular Events After Lung Transplantation in Patients With Pulmonary Arterial Hypertension Receiving Preoperative Long-Term Intravenous Prostacyclin

    Satoshi Akagi, Takahiro Oto, Motomu Kobayashi, Kentaroh Miyoshi, Seiichiro Sugimoto, Masaomi Yamane, Kazufumi Nakamura, Toshihiro Sarashina, Shinichiro Miyoshi, Hiroshi Ito

    INTERNATIONAL HEART JOURNAL   58 ( 4 )   557 - 561   2017.7

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    Adverse cardiovascular events after lung transplantation (LT) increase the mortality in patients with pulmonary arterial hypertension (PAH). Long-term intravenous prostacyclin is the usual treatment in severe patients with PAH, but it may increase the risk of hemorrhage due to its antiplatelet aggregation effect or thrombocytopenia. We investigated the impact of length of intravenous prostacyclin therapy on acute adverse cardiovascular events including hemorrhagic complication after LT. We retrospectively compared the incidence of adverse events (death, intrathoracic hematoma and bleeding, cardiac congestion or shock, cerebral infarction and pulmonary embolism) within 30 days after LT between no/short-term (median 0.6 years, n = 13) and long-term (median 3.7 years, n = 15) intravenous prostacyclin groups. There were no differences in the dose of intravenous prostacyclin and pulmonary artery pressure between the two groups. Among 22 adverse events (0.8 +/- 1.1 events/patient), 4 events occurred in the no/short-term intravenous prostacyclin group and 18 occurred in the long-term intravenous prostacyclin group. The event rate per patient in the long-term intravenous prostacyclin group (1.2 +/- 1.3 events/patient) was significantly higher than that in the no/short-term intravenous prostacyclin group (0.3 +/- 0.5 events/patient) (P &lt; 0.05). Intrathoracic hematoma and bleeding was the most frequent adverse event (9 events, 41%). Preoperative long-term intravenous prostacyclin therapy increases acute adverse cardiovascular events after LT in patients with PAH.

    DOI: 10.1536/ihj.16-389

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  • Complete right bundle branch block and QRS-T discordance can be the initial clue to detect S-ICD ineligibility

    Motomi Tachibana, Nobuhiro Nishii, Yoshimasa Morimoto, Satoshi Kawada, Akihito Miyoshi, Hiroyasu Sugiyama, Koji Nakagawa, Atsuyuki Watanabe, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Ito

    JOURNAL OF CARDIOLOGY   70 ( 1-2 )   23 - 28   2017.7

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    Background: In order to minimize inappropriate shocks of subcutaneous implantable cardioverter-defibrillators (S-ICD), it is important to recognize who is suitable for S-ICD indication. This study aimed to clarify what types of cardiac disease are likely to fulfill the S-ICD screening criteria and ineligible factors for S-ICD in the standard 12-lead electrocardiogram (ECG).
    Methods: A total of 348 patients with heart disease were enrolled. They were assessed by supine and standing ECG recording to simulate the 3 S-ICD sensing vectors and standard 12-lead ECG, simultaneously. Clinical and ECG characteristics were analyzed to compare the patients who are eligible and ineligible with S-ICD screening ECG indication.
    Results: The mean age of study patients was 49 21 years and 244 (70%) were men. Nineteen percent of patients were unsuitable for S-ICD. There was no significant difference in ineligibility for S-ICD among cardiac diseases (p = 0.48). Univariate analysis showed complete right bundle branch block (CRBBB), QRS-T discordance in lead II, and QRS-T discordance in 3 leads (I, II, and aVF) were more frequent in patients who were ineligible for S-ICD than in the eligible group. Multivariate regression analysis showed CRBBB and QRST discordance in 3 leads were independent predictors for ineligibility of S-ICD.
    Conclusion: There are no differences in eligibility of S-ICD among types of cardiac diseases. CRBBB and QRS-T discordance were independent predictors for ineligibility. (C) 2016 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.jjcc.2016.11.014

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  • Epicardially placed implantable cardioverter-defibrillator for a child with congenital long QT syndrome

    Hirotaro Sugiyama, Motomi Tachibana, Hiroshi Morita, Nobuhiro Nishii, Akihito Miyoshi, Hiroyasu Sugiyama, Koji Nakagawa, Atsuyuki Watanabe, Kazufumi Nakamura, Hiroshi Ito

    Journal of Arrhythmia   33 ( 3 )   237 - 239   2017.6

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    A 7-year-old boy presented at our hospital with syncope. At birth, electrocardiography had shown a long QT interval with torsade de pointes (TdP). Congenital long QT syndrome (LQTS) had been diagnosed by genetic testing, and was successfully controlled with oral propranolol. At age 7, TdP had recurred with syncope. Electrocardiography revealed a prominent long QT interval with T-wave alternans. The propranolol dose was increased, but TdP remained uncontrolled. A cardioverter-defibrillator (ICD) was implanted epicardially, and TdP completely resolved with atrial pacing. We report this rare case of ICD implantation in a child with LQTS.

    DOI: 10.1016/j.joa.2016.10.561

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  • Effect of remote ischemia or nicorandil on myocardial injury following percutaneous coronary intervention in patients with stable coronary artery disease: A randomized controlled trial

    Toru Miyoshi, Kentaro Ejiri, Kunihisa Kohno, Makoto Nakahama, Masayuki Doi, Mitsuru Munemasa, Masaaki Murakami, Atsushi Takaishi, Yusuke Kawai, Tetsuya Sato, Katsumasa Sato, Takefumi Oka, Natsuki Takahashi, Satoru Sakuragi, Atsushi Mima, Kenki Enko, Shingo Hosogi, Seiji Nanba, Ryoichi Hirami, Kazufumi Nakamura, Hiroshi Ito

    INTERNATIONAL JOURNAL OF CARDIOLOGY   236   36 - 42   2017.6

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    Background: The effect of remote ischemic preconditioning (RIPC) and nicorandil on periprocedural myocardial injury (pMI) in patients with planned percutaneous coronary intervention (PCI) remains controversial. The aim of this randomized trial was to evaluate the effect of RIPC or nicorandil on pMI following PCI in patients with stable coronary artery disease (CAD) compared with a control group.
    Methods: Patients with stable CAD who planned to undergo PCI were assigned to a 1: 1: 1 ratio to control, RIPC, or intravenous nicorandil (6mg/h). Automated RIPC was performed by a device, which performs intermittent arm ischemia through three cycles of 5min of inflation and 5min of deflation of a pressure cuff. The primary outcome was the incidence of pMI, determined by an elevation in high-sensitive troponin T or creatine kinase myocardial band at 12 or 24 h after PCI. The secondary outcomes were ischemic events during PCI and adverse clinical events at 8 months after PCI.
    Results: A total of 391 patients were enrolled. The incidence of pMI following PCI was not significantly different between the control group (48.9%) and RIPC group (39.5%; p = 0.14), or between the control group and nicorandil group (40.3%; p = 0.17). There were no significant differences in ischemic events during PCI or adverse clinical events within 8 months after PCI among the three groups.
    Conclusions: This study demonstrated moderate reductions in biomarker release and pMI by RIPC or intravenous nicorandil prior to the PCI consistently, but may have failed to achieve statistical significance because the study was underpowered. (C) 2017 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.ijcard.2017.02.028

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  • Comparable effect of aliskiren or a diuretic added on an angiotensin II receptor blocker on augmentation index in hypertension: A multicentre, prospective, randomised study

    Toru Miyoshi, Takashi Murakami, Satoru Sakuragi, Masayuki Doi, Seiji Nanba, Atsushi Mima, Youkou Tominaga, Takafumi Oka, Yutaka Kajikawa, Kazufumi Nakamura, Hiroshi Ito

    Open Heart   4 ( 1 )   296 - 301   2017.3

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    Background The effects of antihypertensive drug combination therapy on central blood pressure (BP) and augmentation index (AI) have not been fully elucidated. We investigated the effects of the direct renin inhibitor, aliskiren, or a diuretic added to an angiotensin II receptor blocker on AI in patients with essential hypertension. Methods A 24-week, prospective, multicentre, randomised, open-label study enrolled 103 patients already treated with valsartan. Participants were randomly allocated to receive either valsartan with aliskiren (V+A), or valsartan with trichlormethiazide (V+T). The primary outcome was the change in AI derived from radial artery tonometry. Secondary outcome measures included systolic and diastolic BP, cardio-ankle vascular index (CAVI, which reflects arterial stiffness) and urinary 8-hydroxydeoxyguanosine concentration. Results After 24 weeks, systolic and diastolic BP were significantly reduced in both groups to a broadly comparable extent. There was no significant difference in AI at the end of the study between the V+A group and the V+T group (between-group difference: -2.3%, 95% CI -6.9% to 2.2%, p=0.31). Central BP at the end of the study also did not differ between the two groups (p=0.62). There was no significant difference in the CAVI between the groups at the end of the study. Urinary 8-hydroxydeoxyguanosine concentration was significantly lower in the V+A group than in the V+T group (p &lt
    0.01), suggesting that V+A attenuated oxidative stress more than V+T. Conclusion The combination of valsartan and aliskiren had an effect on AI comparable with that of the combination of valsartan and trichlormethiazide.

    DOI: 10.1136/openhrt-2017-000591

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  • Reverse Right Ventricular Remodeling After Lung Transplantation in Patients With Pulmonary Arterial Hypertension Under Combination Therapy of Targeted Medical Drugs

    Toshihiro Sarashina, Kazufumi Nakamura, Satoshi Akagi, Takahiro Oto, Hiroki Oe, Kentaro Ejiri, Koji Nakagawa, Nobuhiro Nishii, Hiromi Matsubara, Motomu Kobayashi, Hiroshi Morimatsu, Shinichiro Miyoshi, Hiroshi Ito

    CIRCULATION JOURNAL   81 ( 3 )   383 - 390   2017.3

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    Background: Patients with pulmonary arterial hypertension (PAH) are currently treated with combination therapy of PAH-targeted drugs. Reverse right ventricular (RV) remodeling after lung transplantation (LTx) in patients with end-stage PAH despite combination therapy of PAH-targeted drugs has not been fully elucidated.
    Methods and Results: A total of 136 patients, including 32 with PAH, underwent LTx from 1998 to 2014. We enrolled 12 consecutive patients with PAH treated with combination therapy of PAH-targeted drugs who underwent LTx and retrospectively analyzed the temporal and serial changes in hemodynamics and echocardiography before LTx and at 3 and 12 months after LTx. Before LTx, the RV was markedly dilated with substantially reduced RV fractional area change (RVFAC). At 3 months after LTx, pulmonary artery pressure, pulmonary vascular resistance and RV stroke work index were significantly decreased, while left ventricular stroke work index was increased. RV size assessed by echocardiography also significantly decreased and RVFAC improved. At 12 months after LTx, RVFAC was further increased and RV wall thickness was decreased significantly.
    Conclusions: Although severe RV dysfunction and dilation were observed in patients with end-stage PAH despite combination therapy of PAH-targeted drugs, RV function and morphology were improved after reduction of RV pressure load by LTx.

    DOI: 10.1253/circj.CJ-16-0838

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  • Local Left Ventricular Epicardial J Waves and Late Potentials in Brugada Syndrome Patients with Inferolateral Early Repolarization Pattern

    Satoshi Nagase, Masamichi Tanaka, Hiroshi Morita, Koji Nakagawa, Tadashi Wada, Masato Murakami, Nobuhiro Nishii, Kazufumi Nakamura, Hiroshi Ito, Tohru Ohe, Kengo F. Kusano

    FRONTIERS IN PHYSIOLOGY   8 ( JAN )   947 - 60   2017.1

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    Background: Brugada syndrome (BrS) is characterized by J-point or ST-segment elevation on electrocardiograms (ECGs) and increased risk of ventricular fibrillation (VF). In BrS, epicardial depolarization abnormality with delayed potential on the right ventricular outflow tract is reportedly the predominant mechanism underlying VF. Yet VF occurrence is also associated with early repolarization (ER) pattern in the inferolateral ECG leads, which may represent the inferior and/or left lateral ventricular myocardium. The aim of this study was to examine epicardial electrograms recorded directly at the left ventricle (LV) in BrS patients after VF episodes.
    Methods: In 12 BrS patients who had experienced VF episodes and 17 control subjects, a multipolar catheter was introduced into the left lateral coronary vein for unipolar and bipolar electrogram recordings at the LV epicardium. Both inferior and lateral ER patterns on ECG were observed in three BrS patients and six control subjects.
    Results: In the epicardium, prominent J waves were detected using unipolar recording, and potentials after the QRS complex were detected using bipolar recording in three of the 12 BrS patients. These three patients also showed both inferior and lateral ER patterns on ECG. Neither prominent J waves nor potentials after the QRS complex were recorded at the endocardium of the LV in any of these three patients; nor were they seen at the epicardium in any of the control subjects. These features were accentuated on pilsicainide administration (n = 2) but diminished on constant atrial pacing (n = 3) and isoproterenol administration (n = 1). The J waves observed through unipolar recording coincided with the potentials after QRS complex observed through bipolar recording and with the inferolateral ER patterns on ECG.
    Conclusions: We recorded prominent J waves in unipolar electrogram and potentials after QRS complex in bipolar electrogram at the LV epicardium in BrS patients with global ER pattern. The prominent J waves coincided with the potentials after QRS complex and the inferolateral ER pattern on ECG. The characteristics of the inferolateral ER pattern on ECG in these patients primarily represent depolarization feature.

    DOI: 10.3389/fphys.2017.00014

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  • Identification of electrocardiographic risk markers for the initial and recurrent episodes of ventricular fibrillation in patients with Brugada syndrome

    Hiroshi Morita, Atsuyuki Watanabe, Satoshi Kawada, Masakazu Miyamoto, Yoshimasa Morimoto, Koji Nakagawa, Nobuhiro Nishii, Kazufumi Nakamura, Hiroshi Ito

    Journal of Cardiovascular Electrophysiology, Journal of Electrophysiology, Clinical Progress in Electrophysiology and Pacing, Clinical Progress in Pacing and Electrophysiology   20 - 33   2017

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  • 治療に難渋した壊死性好酸球性心筋炎の1例(共著)

    小出祐嗣, 中村一文, 木村朋生, 中川晃志, 三好 亨, 西井伸洋, 伊藤 浩, 大澤 晋, 笠原慎吾, 田中健大, 柳井広之, 安藤 翠, 大郷恵子, 山中俊明

    心臓   49 ( Suppl1 )   159 - 167   2017

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  • Progression of pulmonary artery dilatation in patients with pulmonary hypertension coexisting with a pulmonary artery aneurysm

    Satoshi Akagi, Kazufumi Nakamura, Toshihiro Sarashina, Kentaro Ejiri, Shingo Kasahara, Hiroshi Ito

    Journal of Cardiology   571 - 579   2017

  • Serum cystatin C levels are associated with coronary artery calcification in women without chronic kidney disease

    Hiroyasu Sugiyama, Toru Miyoshi, Kazuhiro Osawa, Takashi Miki, Yuji Koide, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Ito

    Journal of Cardiology   283 - 289   2017

  • ACE阻害薬、ARB(共著)

    谷本匡史, 中村一文

    薬局   68 ( 7 )   54 - 59   2017

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  • 特集 肺高血圧症-診断と治療の新展開-肺動脈性肺高血圧症基礎研究の進歩(共著)

    中村一文, 江尻健太郎, 赤木 達

    最新医学   72 ( 8 )   49 - 53   2017

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  • Analysis of arrhythmic events is useful to detect lead failure earlier in patients followed by remote monitoring

    Nobuhiro Nishii, Akihito Miyoshi, Motoki Kubo, Masakazu Miyamoto, Yoshimasa Morimoto, Satoshi Kawada, Koji Nakagawa, Atsuyuki Watanabe, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Ito

    Journal of Cardiovascular Electrophysiology, Journal of Electrophysiology, Clinical Progress in Electrophysiology and Pacing, Clinical Progress in Pacing and Electrophysiology   379 - 386   2017

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  • Exercise stress test reveals ineligibility for subcutaneous implantable cardioverter defibrillator in patients with Brugada syndrome

    Motomi Tachibana, Nobuhiro Nishii, Hiroshi Morita, Koji Nakagawa, Atsuyuki Watanabe, Kazufumi Nakamura, Hiroshi Ito

    Journal of Cardiovascular Electrophysiology, Journal of Electrophysiology, Clinical Progress in Electrophysiology and Pacing, Clinical Progress in Pacing and Electrophysiology   38 - 44   2017

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  • Measurement of epicardial fat thickness by transthoracic echocardiography for predicting high-risk coronary artery plaques

    Motomi Tachibana, Toru Miyoshi, Kazuhiro Osawa, Norihisa Toh, Hiroki Oe, Kazufumi Nakamura, Takanori Naito, Shuhei Sato, Susumu Kanazawa, Hiroshi Ito

    HEART AND VESSELS   31 ( 11 )   1758 - 1766   2016.11

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    Epicardial adipose tissue (EAT) volume is reported to be associated with coronary plaques. We evaluated whether non-invasive measurement of EAT thickness by echocardiography can predict high-risk coronary plaque characteristics determined independently by coronary computed tomography (CT) angiography. We enrolled 406 patients (mean age 63 years, 57 % male) referred for 64-slice CT. EAT was measured on the right ventricle free wall from a parasternal long-axis view at the end of systole. High-risk coronary plaques were defined as low-density plaques (&lt; 30 Hounsfield units) with positive remodeling (remodeling index &gt; 1.05). Patients were divided into thin or thick EAT groups using a cutoff value derived from receiver operator characteristic curve analysis for discriminating high-risk plaques. The receiver operator characteristic cutoff value was 5.8 mm with a sensitivity of 83 % and specificity of 64 % (area under the curve 0.77, 95 % confidence interval 0.70-0.83, p &lt; 0.01). Compared with the thin EAT group, the thick EAT group had a high prevalence of low-density plaques (4 vs. 24 %, p &lt; 0.01), positive remodeling (39 vs. 60 %, p &lt; 0.01), and high-risk plaques (3 vs. 17 %, p &lt; 0.01). Multiple logistic analysis revealed that thick EAT was a significant predictor of high-risk plaques (odds ratio 7.98, 95 % confidence interval 2.77-22.98, p &lt; 0.01) after adjustment for covariates, including conventional risk factors, visceral adipose tissue area, and medications. The measurement of EAT thickness by echocardiography may provide a non-invasive option for predicting high-risk coronary plaques.

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  • Intratracheal Administration of Prostacyclin Analogue-incorporated Nanoparticles Ameliorates the Development of Monocrotaline and Sugen-Hypoxia-induced Pulmonary Arterial Hypertension

    Satoshi Akagi, Kazufumi Nakamura, Hiromi Matsubara, Megumi Kondo, Daiji Miura, Tetsuya Matoba, Kensuke Egashira, Hiroshi Ito

    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY   67 ( 4 )   290 - 298   2016.4

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    Nanoparticles (NPs) have been used as novel drug delivery systems. Drug-incorporated NPs for local delivery might optimize the efficacy and minimize the side effects of drugs. Intravenous prostacyclin improves long-term survival in patients with pulmonary arterial hypertension (PAH), but it causes serious side effects such as catheter-related infections. We investigated the efficacy and safety of intratracheal administration of a prostacyclin analogue, beraprost (BPS), incorporated NPs in Sugen-hypoxia-normoxia and monocrotaline rat models of PAH and in human PAH pulmonary arterial smooth muscle cells (PASMCs). After a single administration, BPS NPs significantly decreased right ventricular pressure, right ventricular hypertrophy, and pulmonary artery muscularization in the 2 rat models. BPS NPs significantly improved the survival rate in the monocrotaline rat model. No infiltration of inflammatory cells, hemorrhage, or fibrosis was found in the liver, kidney, spleen, and heart after the administration of BPS NPs. No liver or kidney dysfunction was found in the blood examinations. BPS and BPS NPs significantly inhibited the proliferation of human PAH PASMCs after 24 hours of treatment. BPS NPs significantly continued to inhibit the proliferation of human PAH PASMCs at 24 hours after the removal of BPS NPs. BPS NPs significantly induced apoptosis in PAH PASMCs compared to that in non-PAH PASMCs. Intratracheal administration of BPS NPs ameliorates pulmonary hypertension in PAH rat models by a sustained antiproliferative effect and a proapoptotic effect on PAH PASMCs.

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  • Association between coronary artery calcification and left ventricular diastolic dysfunction in elderly people

    Kazuhiro Osawa, Toru Miyoshi, Hiroki Oe, Shuhei Sato, Kazufumi Nakamura, Kunihisa Kohno, Hiroshi Morita, Susumu Kanazawa, Hiroshi Ito

    HEART AND VESSELS   31 ( 4 )   499 - 507   2016.4

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    Coronary artery calcification (CAC) is associated with the incidence of congestive heart failure. We evaluated the association between CAC and left ventricular diastolic dysfunction (LVDD) in elderly patients without coronary artery disease. Coronary computed tomography was performed in 1,021 consecutive patients &gt; 55 years of age who were suspected of having coronary artery disease. A total of 530 patients (age, 70 +/- A 8 years; 56 % men) with a LV ejection fraction &gt; 50 % and without obstructive coronary artery disease and a history of coronary artery disease were included in the analysis. LVDD was defined according to a standard algorithm by echocardiography (septal e' &lt; 8, lateral e' &lt; 10, and left atrial volume index a parts per thousand yen34 mL/m(2)). A total of 224 of 530 patients had LVDD. CAC scores in patients with LVDD were higher than those in patients without LVDD (p &lt; 0.01). The prevalence of LVDD in patients with CAC scores a parts per thousand yen400 was greater than that in patients with CAC scores of 0-9 (58 vs. 34 %, p &lt; 0.01). After adjustment for confounding factors, the CAC score was associated with LVDD, with an odds ratio of 1.96 (95 % confidence interval: 1.11-3.43, p = 0.02) for a CAC score a parts per thousand yen400 compared with a CAC score of 0-9. A CAC score a parts per thousand yen400 was associated with LVDD in elderly patients without CAD in this population. Further prospective studies are needed to evaluate the clinical relevance of CAC as a risk of heart failure with preserved ejection fraction.

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  • Constitutively active form of natriuretic peptide receptor 2 ameliorates experimental pulmonary arterial hypertension

    Nobutoshi Nawa, Hidekazu Ishida, Shinichi Katsuragi, Hiroki Baden, Kunihiko Takahashi, Ryota Higeno, Fumiko Torigoe, Seiko Mihara, Jun Narita, Kohji Miura, Kazufumi Nakamura, Shigetoyo Kogaki, Keiichi Ozono

    Molecular Therapy - Methods and Clinical Development   3   16044 - 16044   2016.3

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    We recently found a constitutively active mutant of natriuretic peptide receptor 2 (caNPR2
    V883M), which synthesizes larger amounts of cyclic guanosine monophosphate (cGMP) intracellularly without any ligand stimulation than existing drugs. The aim of this study was to investigate the therapeutic effects of gene transduction using caNPR2 for pulmonary arterial hypertension (PAH). In vitro gene transduction into human pulmonary arterial smooth muscle cells using Sendai virus (SeV) vectors carrying caNPR2 induced 10,000-fold increases in the synthesis of cGMP without ligand stimulation, and the proliferation of caNPR2-expressing cells was significantly attenuated. The PAH model rats generated by hypoxia and the administration of SU5416 were then treated with SeV vectors through a direct injection into the left pulmonary artery. Right ventricular systolic pressure was significantly decreased 2 weeks after the treatment, while systemic blood pressure remained unchanged. Histological analyses revealed that the medial wall thickness and occlusion rate of pulmonary arterioles were significantly improved in caNPR2-treated lungs. Neither the systemic integration of virus vectors nor side effects were observed. The massive stimulation of cGMP synthesis by gene therapy with caNPR2 was safe and effective in a PAH rat model and, thus, has potential as a novel therapy for patients with severe progressive PAH.

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  • Postprandial hyperlipidemia as a potential residual risk factor

    Kazufumi Nakamura, Toru Miyoshi, Kei Yunoki, Hiroshi Ito

    JOURNAL OF CARDIOLOGY   67 ( 3-4 )   335 - 339   2016.3

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    Statin therapy targeting reduction of low-density lipoprotein cholesterol (LDL-C) decreases the risk of coronary heart disease (CHD) and all-cause mortality. However, a substantial number of cases of CHD are not prevented and residual risk factors remain unsettled. A high triglyceride (TG) level is considered to be an important and residual risk factor. Postprandial hyperlipidemia is a condition in which TG-rich chylomicron remnants are increased during the postprandial period and hypertriglycedemia is protracted. Postprandial hyperlipidemia evokes atherogenesis during the postprandial period. Several prospective studies have revealed that nonfasting serum TG levels predict the incidence of CHD. Values of TG, remnant lipoprotein cholesterol, and remnant lipoprotein TG after fat loading were significantly higher in diabetes patients with insulin resistance than in diabetes patients without insulin resistance.
    Endothelial dysfunction is an initial process of atherogenesis and it contributes to the pathogenesis of CHD. Postprandial hyperlipidemia (postprandial hypertriglyceridemia) is involved in the production of proinflammatory cytokines, recruitment of neutrophils, and generation of oxidative stress, resulting in endothelial dysfunction in healthy subjects, hypertriglyceridemic patients, or type 2 diabetic patients.
    Effective treatment has not been established till date. Ezetimibe or omega-3 fatty acids significantly decrease postprandial TG elevation and postprandial endothelial dysfunction. Ezetimibe or omega-3 fatty acids added to statin therapy reduce serum TG levels and result in good outcomes in patients with CHD.
    In conclusion, postprandial hyperlipidemia is an important and residual risk factor especially in patients with insulin resistance syndrome (metabolic syndrome) and diabetes mellitus. Further studies are needed to establish effective treatment. (C) 2015 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

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  • Celsior preserves cardiac mechano-energetics better than University of Wisconsin solution by preventing oxidative stress

    Takahiko Kiyooka, Yu Oshima, Waso Fujinaka, Gentaro Iribe, Juichiro Shimizu, Satoshi Mohri, Kazufumi Nakamura

    INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY   22 ( 2 )   168 - 175   2016.2

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    OBJECTIVES: Identity of the optimal heart preservation solution remains unknown. Because oxidative stress contributes to contractile failure in the ischaemic/reperfused myocardium and the main characteristic of Celsior is its antioxidant effect, it is important to elucidate the relationship between the inhibitory effect on oxidative stress and cardiac mechano-energetics. We therefore evaluated the efficacy of Celsior from both aspects by comparison with the University of Wisconsin solution (UWS).
    METHODS: We used 18 excised cross-circulated canine hearts. Excised hearts were preserved with UWS (n = 6) or Celsior (n = 6) for 3 h at 4 degrees C; the remaining six served as controls. Hearts were then cross-circulated and rewarmed. The end-systolic pressure-volume ratio (LV E-max) and the ventricular pressure-volume area, which is a measure of total mechanical energy, were assessed after reperfusion. Biopsies were taken from the endocardium after excising the heart, before reperfusion, after reperfusion and 4 h after reperfusion to assess the inhibitory effect of each agent on oxidative stress. Endo-myocardial biopsy samples were studied immunohistochemically for expression of 4-hydroxy-2-nonenal (HNE)-modified protein, which is a major lipid peroxidation product.
    RESULTS: E-max in the UWS group was significantly smaller than in the control group, whereas the E-max in the Celsior group was preserved. Oxygen cost of E-max in the UWS group was significantly higher than in the Celsior group. Myocardial HNE-modified protein levels increased gradually, both under preservation and after reperfusion in the UWS group. Myocardial HNE-modified protein levels in the Celsior group were lower, mainly before and 4 h after reperfusion compared with the UWS group.
    CONCLUSIONS: Celsior may maintain cardiac contractility and conserve oxygen cost by inhibiting oxidative stress.

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  • Clinical characteristics of responders to treatment with tolvaptan in patients with acute decompensated heart failure: Importance of preserved kidney size

    Hironobu Toda, Kazufumi Nakamura, Makoto Nakahama, Tadashi Wada, Atsuyuki Watanabe, Bkatsushi Hashimoto, Ritsuko Terasaka, Koji Tokioka, Nobuhiro Nishii, Toru Miyoshi, Kunihisa Kohno, Yusuke Kawai, Kohei Miyaji, Yuji Koide, Motomi Tachibana, Ryo Yoshioka, Hiroshi Ito

    JOURNAL OF CARDIOLOGY   67 ( 1-2 )   177 - 183   2016.1

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    Background: Recent clinical trials have demonstrated the efficacy of short-term treatment with tolvaptan, an oral vasopressin V2 receptor antagonist, in patients with heart failure. However, the response to tolvaptan varies among patients. The aim of this study was to determine factors associated with response to tolvaptan in patients with acute decompensated heart failure (ADHF).
    Methods: The Tolvaptan Registry, a prospective, observational, multicenter cohort study performed in Japan, aims to determine factors affecting the responsiveness of tolvaptan in patients with ADHF. We enrolled ADHF patients treated with tolvaptan and they were divided into two groups: responders and non-responders. Responders were defined as subjects who met all of the following three conditions: (1) increasing urine volume during a 24-hour period after the start of tolvaptan treatment; (2) improvement in New York Heart Association functional class; and (3) decrease in cardiothoracic ratio assessed by chest X-ray on day 3 of tolvaptan administration.
    Results: Among the 114 patients, treatment with tolvaptan improved three conditions of heart failure in more than half of all the cohorts (71 patients, 62%). As for baseline characteristics, estimated glomerular filtration rate, urine osmolality, and kidney size were significantly greater in responders than in non responders. Multivariate logistic analysis revealed that kidney size was independently associated with responders (odds ratio: 1.083, p = 0.001, 95% confidence interval 1.031-1.137).
    Conclusions: The main clinical characteristic of responders to treatment with tolvaptan is that kidney size is preserved. (C) 2015 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

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  • Treatment for pulmonary hypertension due to left heart diseases

    Kazufumi Nakamura

    HYPERTENSION RESEARCH   39 ( 1 )   6 - 7   2016.1

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    DOI: 10.1038/hr.2015.116

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  • PCPS管理にて経過良好で後遺症なく独歩退院できた劇症型心筋炎の一例

    大塚寛昭, 中村一文, 網岡尚史, 木村朋生, 中川晃志, 赤木達, 笠原真悟, 清水一好, 渡邊謙, 伊藤浩

    日本循環器学会中国地方会(Web)   109th   2016

  • Translational research on pulmonary hypertension(共著)

    Kazufumi Nakamura, Satoshi Akagi

    Respiration and Circulation   64 ( 6 )   582 - 587   2016

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  • Feasibility of repairing defects followed by treatment with pulmonary hypertension-specific drugs (repair and treat) in patients with pulmonary hypertension associated with atrial septal defect(共著)

    Satoshi Akagi, Kazufumi Nakamura, Teiji Akagi, Koji Nakagawa, Yoichi Takaya, Toshihiro Sarashina, Kentaro Ejiri, Hiroshi Ito

    Acta Medica Okayama, Acta. Medica Okayama, Acta medicinae Okayama, Acta medica Okayama   70 ( 5 )   397 - 400   2016

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  • 初期スクリーニング・病態評価における心エコー検査の意義・現時点での限界・将来性(共著)

    更科俊洋, 赤木 達, 麻植浩樹, 中村一文, 伊藤 浩

    内科   117 ( 3 )   383 - 390   2016

  • 心拍数(共著)

    杉山洋樹, 中村一文

    日本臨床   74 ( 4 )   284 - 287   2016

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  • 肺高血圧症の基礎研究から臨床研究への橋渡し(共著)

    中村一文, 赤木 達

    呼吸と循環   64 ( 6 )   582 - 587   2016

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  • Incidence and Clinical Significance of Brugada Syndrome Masked by Complete Right Bundle-Branch Block

    Tadashi Wada, Satoshi Nagase, Hiroshi Morita, Koji Nakagawa, Nobuhiro Nishii, Kazufumi Nakamura, Kunihisa Kohno, Hiroshi Ito, Kengo F. Kusano, Tohru Ohe

    CIRCULATION JOURNAL   79 ( 12 )   2568 - +   2015.11

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    Background: Brugada syndrome (BrS)-type electrocardiogram (ECG) is concealed by complete right bundle-branch block (CRBBB) in some cases of BrS. Clinical significance of BrS masked by CRBBB is not well known.
    Methods and Results: We reviewed an ECG database of 326 BrS patients who had type 1 ECG with or without pilsicainide. "BrS masked by CRBBB" was defined on ECG as &lt;2-mm elevation of the J point at the time of CRBBB in the right precordial leads, and BrS-type J-point elevation &gt;= 2 mm at the time of normalized QRS complex on relieved CRBBB. We identified 25 BrS patients (7.7%) with persistent (n=12) or intermittent CRBBB (n=13). Relief of CRBBB by pacing was performed in patients with persistent CRBBB. The prevalence of BrS masked by CRBBB was 3.1% (10/326 patients). Three patients had type 1 ECG, and 7 patients had type 2 or 3 ECG on relief of CRBBB. Two of these 10 patients had lethal arrhythmic events during the follow-up period (mean, 86.4+/-57.2 months). There was no prognostic difference between BrS masked by CRBBB and other BrS.
    Conclusions: In a small BrS population, CRBBB can completely mask typical BrS-type ECG. BrS masked by CRBBB is associated with the same risk of fatal ventricular tachyarrhythmia as other BrS.

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  • Prognostic significance of endothelial dysfunction in patients undergoing percutaneous coronary intervention in the era of drug-eluting stents

    Motoki Kubo, Toru Miyoshi, Hiroki Oe, Yuko Ohno, Kazufumi Nakamura, Hiroshi Ito

    BMC CARDIOVASCULAR DISORDERS   15 ( 1 )   102 - 102   2015.9

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    Background: Endothelial function is a prognostic predictor in patients undergoing percutaneous coronary intervention (PCI). However, in an era with widespread use of drug-eluting stents, the clinical relevance of endothelial dysfunction on restenosis in patients undergoing PCI has not been fully evaluated.
    Methods: This study included 80 patients with stable angina pectoris. Flow-mediated dilation (FMD) of the brachial artery was examined 1 week after PCI. Patients were retrospectively followed-up for an average of 21 months after PCI. The primary endpoints included cardiac death, nonfatal myocardial infarction, stroke, coronary revascularization, and critical limb ischemia.
    Results: A drug-eluting stent was used in 58 patients and a cardiovascular event was recorded in 34 patients during follow-up. The incidence of all cardiovascular diseases was significantly greater in the low FMD (median FMD &lt;4.2 %) than the high FMD (median FMD &gt;= 4.2 %) group (60 % vs. 25 %, p &lt;0.01). Furthermore, the incidence of coronary revascularization was significantly higher in the low than the high FMD group (p = 0.02), while the incidence of in-stent restenosis did not differ between the two groups. Cox regression analysis showed that low FMD was an independent predictor of cardiovascular events (hazard ratio: 2.77, 95 % confidence interval: 1.23 to 6.19, p = 0.01).
    Conclusions: Impaired brachial artery FMD independently predicts long-term cardiovascular events after PCI in the era of drug-eluting stents.

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  • Enhancement of Spontaneous Activity by HCN4 Overexpression in Mouse Embryonic Stem Cell-Derived Cardiomyocytes - A Possible Biological Pacemaker

    Yukihiro Saito, Kazufumi Nakamura, Masashi Yoshida, Hiroki Sugiyama, Tohru Ohe, Junko Kurokawa, Tetsushi Furukawa, Makoto Takano, Satoshi Nagase, Hiroshi Morita, Kengo F. Kusano, Hiroshi Ito

    PLOS ONE   10 ( 9 )   e0138193-e0138193   2015.9

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    Background
    Establishment of a biological pacemaker is expected to solve the persisting problems of a mechanical pacemaker including the problems of battery life and electromagnetic interference. Enhancement of the funny current (If) flowing through hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and attenuation of the inward rectifier K+ current (I-K1) flowing through inward rectifier potassium (K-ir) channels are essential for generation of a biological pacemaker. Therefore, we generated HCN4-overexpressing mouse embryonic stem cells (mESCs) and induced cardiomyocytes that originally show poor I-K1 currents, and we investigated whether the HCN4-overexpressing mESC-derived cardiomyocytes (mESC-CMs) function as a biological pacemaker in vitro.
    Methods and Results
    The rabbit Hcn4 gene was transfected into mESCs, and stable clones were selected. mESC-CMs were generated via embryoid bodies and purified under serum/glucose-free and lactate-supplemented conditions. Approximately 90% of the purified cells were troponin I-positive by immunostaining. In mESC-CMs, expression level of the Kcnj2 gene encoding K(ir)2.1, which is essential for generation of I-K1 currents that are responsible for stabilizing the resting membrane potential, was lower than that in an adult mouse ventricle. HCN4-overexpressing mESC-CMs expressed about a 3-times higher level of the Hcn4 gene than did non-overexpressing mESC-CMs. Expression of the Cacna1h gene, which encodes T-type calcium channel and generates diastolic depolarization in the sinoatrial node, was also confirmed. Additionally, genes required for impulse conduction including Connexin40, Connexin43, and Connexin45 genes, which encode connexins forming gap junctions, and the Scn5a gene, which encodes sodium channels, are expressed in the cells. HCN4-overexpressing mESC-CMs showed significantly larger I-f currents and more rapid spontaneous beating than did non-overexpressing mESC-CMs. The beating rate of HCN4-overexpressing mESC-CMs responded to ivabradine, an I-f inhibitor, and to isoproterenol, a beta-adrenergic receptor agonist. Co-culture of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) with aggregates composed of mESC-CMs resulted in synchronized contraction of the cells. The beating rate of hiPSC-CMs co-cultured with aggregates of HCN4-overexpressing mESC-CMs was significantly higher than that of nontreated hiPSC-CMs and that of hiPSC-CMs co-cultured with aggregates of non-overexpressing mESC-CMs.
    Conclusions
    We generated HCN4-overexpresssing mESC-CMs expressing genes required for impulse conduction, showing rapid spontaneous beating, responding to an I-f inhibitor and beta-adrenergic receptor agonist, and having pacing ability in an in vitro co-culture system with other excitable cells. The results indicated that these cells could be applied to a biological pacemaker.

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  • Impact of Ezetimibe Alone or in Addition to a Statin on Plasma PCSK9 Concentrations in Patients with Type 2 Diabetes and Hypercholesterolemia: A Pilot Study

    Toru Miyoshi, Keigo Nakamura, Masayuki Doi, Hiroshi Ito

    AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS   15 ( 3 )   213 - 219   2015.6

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    Background and Aim The increase in proprotein convertase subtilisin/kexin type 9 (PCSK9) leads to low-density lipoprotein (LDL) receptor degradation. Statins significantly reduce LDL-cholesterol levels, but upregulate PCSK9. This study evaluated the effect of ezetimibe monotherapy or ezetimibe in combination with a statin on serum levels of PCSK9 in patients with type 2 diabetes and hypercholesterolemia.
    Methods Ezetimibe treatment was given to ten patients with diabetes without statin therapy and ten patients with statin therapy. Plasma levels of PCSK9 were examined at baseline and 24 weeks after treatment.
    Results At baseline, PCSK9 concentrations in patients with statin therapy were significantly higher than those in patients without statin use and in control subjects [median (25th-75th percentile) 411 (272-467) and 382 (356-453) ng/mL, respectively, p&lt;0.01]. After ezetimibe treatment for 24 weeks, LDL-cholesterol, triglyceride and remnant-like lipoprotein cholesterol were significantly decreased in both groups. However, PCSK9 concentration did not change compared with baseline measurements in both groups. The percentage change in LDL-cholesterol after ezetimibe therapy for 24 weeks was not correlated with the percentage change in PCSK9 concentration.
    Conclusion Ezetimibe may reduce LDL-cholesterol levels without affecting PCSK9 in patients with type 2 diabetes and hypercholesterolemia.

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  • Comparison of effects of sitagliptin and voglibose on left ventricular diastolic dysfunction in patients with type 2 diabetes: results of the 3D trial

    Hiroki Oe, Kazufumi Nakamura, Hajime Kihara, Kenei Shimada, Shota Fukuda, Tsutomu Takagi, Toru Miyoshi, Kumiko Hirata, Junichi Yoshikawa, Hiroshi Ito

    CARDIOVASCULAR DIABETOLOGY   14   83 - 83   2015.6

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    Background: Left ventricular ( LV) diastolic dysfunction is frequently observed in patients with type 2 diabetes. Dipeptidyl peptidase-4 inhibitor ( DPP-4i) attenuates postprandial hyperglycemia ( PPH) and may have cardio-protective effects. It remains unclear whether DPP-4i improves LV diastolic function in patients with type 2 diabetes, and, if so, it is attributable to the attenuation of PPH or to a direct cardiac effect of DPP-4i. We compared the effects of the DPP-4i, sitagliptin, and the alpha-glucosidase inhibitor, voglibose, on LV diastolic function in patients with type 2 diabetes.
    Methods: We conducted a prospective, randomized, open-label, multicenter study of 100 diabetic patients with LV diastolic dysfunction. Patients received sitagliptin ( 50 mg/day) or voglibose ( 0.6 mg/day). The primary endpoints were changes in the e' velocity and E/e' ratio from baseline to 24 weeks later. The secondary efficacy measures included HbA1c, GLP-1, lipid profiles, oxidative stress markers and inflammatory markers.
    Results: The study was completed with 40 patients in the sitagliptin group and 40 patients in the voglibose group. There were no significant changes in the e' velocity and E/e' ratio from baseline to 24 weeks later in both groups. However, analysis of covariance demonstrated that pioglitazone use is an independent factor associated with changes in the e' and E/e' ratio. Among patients not using pioglitazone, e' increased and the E/e' ratio decreased in both the sitagliptin and voglibose groups. GLP-1 level increased from baseline to 24 weeks later only in the sitagliptin group ( 4.8 +/- 4.7 vs. 7.3 +/- 5.5 pmol/L, p &lt; 0.05). The reductions in HbA1c and body weight were significantly greater in the sitagliptin group than in the voglibose group (-0.7 +/- 0.6 % vs. -0.3 +/- 0.4, p &lt; 0.005; -1.3 +/- 3.2 kg vs. 0.4 +/- 2.8 kg, p &lt; 0.05, respectively). There were no changes in lipid profiles and inflammatory markers in both groups.
    Conclusions: Our trial showed that sitagliptin reduces HbA1c levels more greatly than voglibose does, but that neither was associated with improvement in the echocardiographic parameters of LV diastolic function in patients with diabetes.

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  • Nonalcoholic Hepatic Steatosis Is a Strong Predictor of High-Risk Coronary-Artery Plaques as Determined by Multidetector CT

    Kazuhiro Osawa, Toru Miyoshi, Kentarou Yamauchi, Yasushi Koyama, Kazufumi Nakamura, Shuhei Sato, Susumu Kanazawa, Hiroshi Ito

    PLOS ONE   10 ( 6 )   e0131138-e0131138   2015.6

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    Background
    Nonalcoholic fatty liver disease is associated with a risk of coronary artery disease (e.g., diabetes mellitus, dyslipidemia, metabolic syndrome). We evaluated whether nonalcoholic hepatic steatosis is associated with high-risk plaques as assessed by multidetector computed tomography (CT).
    Methods
    This retrospective study involved 414 participants suspected of having coronary artery disease. Nonalcoholic hepatic steatosis was defined as a liver-to-spleen fat ratio of &lt;1.0 and the presence and appropriate characteristics of coronary-artery plaques as assessed by coronary CT angiography. High-risk plaques were identified, as were low-density plaques, positive remodeling, and spotty calcification.
    Results
    Compared with patients who did not have nonalcoholic hepatic steatosis, patients with nonalcoholic hepatic steatosis had more low-density plaques (21% vs. 44%, p&lt;0.01), positive remodeling (41% vs. 58%, p = 0.01), and spotty calcification (12% vs. 36%, p&lt;0.01). The number of high-risk plaques in patients with nonalcoholic hepatic steatosis was greater than in those without nonalcoholic hepatic steatosis (p&lt;0.01). Patients with nonalcoholic hepatic steatosis were more likely to have high-risk plaques than were those with only an elevated level of visceral adipose tissue (&gt;= 86 cm(2); 35% vs. 16%, p&lt;0.01). Multivariate analyses that included nonalcoholic hepatic steatosis, amount of visceral adipose tissue, and the presence/absence of traditional risk factors demonstrated that nonalcoholic hepatic steatosis was an independent predictor of high-risk plaques (odds ratio: 4.60; 95% confidence interval: 1.94-9.07, p&lt;0.01).
    Conclusions
    Diagnosis of nonalcoholic hepatic steatosis may be of value when assessing the risk of coronary artery disease.

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  • Comparison of Outcomes in Patients With Probable Versus Definite Cardiac Sarcoidosis

    Yoichi Takaya, Kengo F. Kusano, Kazufumi Nakamura, Hiroshi Ito

    AMERICAN JOURNAL OF CARDIOLOGY   115 ( 9 )   1293 - 1297   2015.5

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    Patients with probable cardiac sarcoidosis (CS) who satisfy only clinical cardiac findings for CS are not uncommon. The aim of this study was to compare outcomes between patients with probable CS and those with definite CS treated with steroids. The study population consisted of 101 consecutive patients who satisfied clinical cardiac findings for CS. Patients with definite CS were defined as having histologic or clinical confirmation of CS according to the guidelines and were treated with steroids. Patients with probable CS were defined as having only clinical cardiac findings but not definite CS because of no histologic confirmation or extracardiac sarcoidosis and were not treated with steroids. The end point was major adverse cardiac events. Forty-seven patients had definite CS, and the other 54 had probable CS. Except for serum angiotensin-converting enzyme levels and left ventricular dysfunction, clinical characteristics were similar between the 2 groups. Over a median follow-up period of 15 months, major adverse cardiac events occurred more frequently in patients with probable CS than in those with definite CS (74% vs 53%, p = 0.029). The event-free survival rate was worse in patients with probable CS than in those with definite CS (log-rank test, p = 0.006). Cox proportional-hazards analysis showed that probable CS was an independent predictor of major adverse cardiac events. In conclusion, outcomes were worse in patients with probable CS than in those with definite CS treated with steroids. The initiation of steroid treatment may be considered for patients who satisfy only clinical cardiac findings for CS. (C) 2015 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.amjcard.2015.01.562

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  • Outcomes in Patients With High-Degree Atrioventricular Block as the Initial Manifestation of Cardiac Sarcoidosis

    Yoichi Takaya, Kengo Fukushima Kusano, Kazufumi Nakamura, Hiroshi Ito

    AMERICAN JOURNAL OF CARDIOLOGY   115 ( 4 )   505 - 509   2015.2

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    Although high-degree atrioventricular block (AVB) is a common initial manifestation of cardiac sarcoidosis, little is known about the outcomes. The aim of this study was to assess outcomes in patients with AVB as an initial manifestation of cardiac sarcoidosis compared with those in patients with ventricular tachyarrhytlunia (VT) and/or heart failure (HF). Fifty-three consecutive patients with cardiac sarcoidosis, who had high-degree AVB (n = 22) or VT and/or HF (n = 31), were enrolled. The end point was defined as major adverse cardiac events, including cardiac death, ventricular fibrillation, sustained VT, and hospitalization for HF. Over a median follow-up period of 34 months, the outcomes of major adverse cardiac events were better in patients with high-degree AVB than in those with VT and/or HF (log-rank test, p = 0.046). However, this difference was due mainly to HF hospitalization. The outcomes of fatal cardiac events, including cardiac death, ventricular fibrillation, and sustained VT, were comparable between the 2 groups (log-rank test, p = 0.877). The fatal cardiac events in patients with high-degree AVB were not associated with the initiation of steroid treatment or left ventricular dysfunction. In conclusion, the outcomes of major adverse cardiac events are better in patients with high-degree AVB than in those with VT and/or HF. However, patients with high-degree AVB have a high rate of fatal cardiac events, similar to those with VT and/or HF. An indication for an implantable cardioverter-defibrillator, but not a pacemaker system, can be considered in patients with cardiac sarcoidosis manifested by high-degree AVB. (C) 2015 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.amjcard.2014.11.028

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  • Remote ischemic preconditioning reduces contrast-induced acute kidney injury in patients with ST-elevation myocardial infarction: A randomized controlled trial

    Toshiaki Yamanaka, Yusuke Kawai, Toru Miyoshi, Tsutomu Mima, Kenji Takagaki, Saori Tsukuda, Yukio Kazatani, Kazufumi Nakamura, Hiroshi Ito

    INTERNATIONAL JOURNAL OF CARDIOLOGY   178   136 - 141   2015.1

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    Background: Contrast medium-induced acute kidney injury (CI-AKI) is a cardiovascular complication after myocardial infarction treated with emergency percutaneous coronary intervention. The aim of this randomized, sham-controlled trial was to evaluate the impact of remote ischemic preconditioning (RIPC) on CI-AKI in patients with ST-elevation myocardial infarction who received emergency primary percutaneous coronary intervention.
    Methods and results: Patients with a suspected ST-elevation myocardial infarction were randomly assigned at a 1: 1 ratio to receive percutaneous coronary intervention eitherwith (n = 63) or without (n = 62) RIPC (intermittent arm ischemia through three cycles of 5 min of inflation and 5 min of deflation of a blood pressure cuff). A total of 47 RIPC patients and 47 control patients met all study criteria. The primary endpoint was the incidence of CI-AKI, which was defined as an increase in serum creatinine &gt;0.5 mg/dL or N25% over the baseline value 48-72 h after administration of contrast medium. The incidence of CI-AKI was 10% (n = 5) in the RIPC group and 36% (n = 17) in the control group (p = 0.003). The odds ratio of CI-AKI in patients who received RIPC was 0.18 (95% confidence interval: 0.05-0.64; p = 0.008).
    Conclusions: In patients with ST-elevation myocardial infarction, RIPC before percutaneous coronary intervention reduced the incidence of CI-AKI. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.ijcard.2014.10.135

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  • Epoprostenol Therapy for Pulmonary Arterial Hypertension(共著)

    Akagi S, Nakamura K, Matsubara H, Ogawa A, Sarashina T, Ejiri K, Ito H

    Acta Med Okayama   69 ( 3 )   129 - 136   2015

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  • ナノ粒子を用いたDrug Delivery System(共著)

    赤木達, 中村一文

    Medical Practice   32 ( 12 )   2001 - 2003   2015

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  • 右室機能を考えなおす 右室後負荷は、どのくらい重要か(共著)

    中村一文, 時岡浩二, 更科俊洋, 赤木 達, 伊藤 浩

    呼吸と循環   63 ( 8 )   S19-S20   2015

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  • 日本から世界に向けて肺高血圧症の基礎研究をどう発信していくか? PGI2封入ナノ粒子を用いた肺高血圧症の新規治療法(共著)

    赤木 達, 中村一文, 更科俊洋, 江頭健輔, 伊藤 浩

    呼吸と循環   63 ( 8 )   S12-S12   2015

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  • 特発性・遺伝性肺動脈性肺高血圧症に対する薬物治療(共著)

    中村一文, 更科俊洋, 江尻健太郎, 赤木 達

    Angiology Frontier   14 ( 2 )   11 - 17   2015

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  • 門脈圧亢進症の病態と治療 基礎から臨床へ 門脈圧亢進症における心肺機能と酸化ストレスについての検討(共著)

    高木章乃夫, 寺尾正子, 安中哲也, 白羽英則, 中村進一郎, 麻植浩樹, 中村一文, 岡田裕之

    日本門脈圧亢進症学会雑誌   21 ( 3 )   67 - 67   2015

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  • 肺高血圧症患者におけるドプラ法を用いた肺血管抵抗推定の有用性(共著)

    麻植浩樹, 池田まどか, 赤木 達, 大野佑子, 更科俊洋, 渡辺修久, 中村一文, 森田 宏, 伊藤 浩

    呼吸と循環   63 ( 8 )   S42-S42   2015

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  • Basiginは血管平滑筋細胞増殖を促進し、肺高血圧症を悪化させる(共著)

    佐藤公雄, 鈴木康太, 大村淳一, 菊池順裕, 矢尾板信裕, 杉村宏一郎, 福本義弘, 中村一文, 伊藤 浩, 下川宏明

    呼吸と循環   63 ( 8 )   S35-S36   2015

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  • 肺高血圧症の血管リモデリングとその治療(共著)

    中村一文, 更科俊洋, 赤木 達

    呼吸と循環   63 ( 8 )   S30-S30   2015

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  • A case of cardiac amyloidosis with ventricular flutter of first symptom

    Ono Tamaki, Morita Hiroshi, Kimura Tomonari, Tokioka Koji, Nakagawa Kouji, Nishii Nobuhiro, Nagase Satoshi, Nakamura Kazuhumi, Ito Hiroshi, Tanaka Takehiro, Yanai Hiroyuki, Ando Midori, Yutani Chikao

    Shinzo   47 ( suppl-1 )   33 - 37   2015

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    DOI: 10.11281/shinzo.47.S1_33

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  • 肺高血圧症~肺高血圧症におけるバイオマーカー測定の意義~(共著)

    更科俊洋, 江尻健太郎, 赤木 達, 中村一文

    Heart View   19 ( 12 )   77 - 82   2015

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  • 目でみる肺高血圧症 肺高血圧症の電子顕微鏡像(共著)

    中村一文, 赤木 達, 三浦 綾, 伊藤 浩

    Pulmonary Hypertension Update   1 ( 2 )   4 - 8   2015

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  • 巨大右室を必須緩徐伝導路とするマクロリエントリー性心室頻拍を合併した成人Ebstein奇形の一例(共著)

    永瀬 聡, 中川晃志, 久保元基, 上岡 亮, 高谷陽一, 西井伸洋, 中村一文, 森田 宏, 伊藤 浩

    日本成人先天性心疾患学会雑誌   4 ( 1 )   172 - 172   2015

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  • 心房中隔欠損症患者における心房細動カテーテルアブレーション後の欠損孔の変化(共著)

    中川晃志, 赤木禎治, 永瀬 聡, 高谷陽一, 西井伸洋, 中村一文, 森田 宏, 伊藤 浩

    日本成人先天性心疾患学会雑誌   4 ( 1 )   118 - 118   2015

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  • 重症不整脈源性右室心筋症に対するFontan手術の検討(共著)

    三好章仁, 永瀬 聡, 中川晃志, 久保元基, 上岡 亮, 西井伸洋, 中村一文, 森田 宏, 伊藤 浩, 佐野俊二

    日本成人先天性心疾患学会雑誌   4 ( 1 )   107 - 107   2015

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  • 肺高血圧に対する薬物治療(共著)

    更科俊洋, 斎藤幸弘, 中村一文

    Heart View   19 ( 3 )   76 - 82   2015

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  • 一瀬論文に対するEditorial Comment

    中村一文

    心臓   47 ( 9 )   1117 - 1117   2015

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  • 動脈グラフト周囲脂肪の炎症に関する検討(共著)

    横田武典, 三隅祐輔, 桝田浩禎, 時岡浩二, 中村一文, 伊藤 浩, 正井崇史

    日本心臓血管外科学会雑誌   44 ( suppl )   380 - 380   2015

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  • 心臓サルコイドーシスにおける加算平均心電図による心室遅延電位 (LP : Late Potential) の特徴(共著)

    寒川睦子, 森田 宏, 中川晃志, 西井伸洋, 永瀬 聡, 中村一文, 河野晋久, 伊藤 浩, 草野研吾, 大江 透

    心電図   35 ( suppl-1 )   5023 - 5023   2015

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  • 肺動脈性肺高血圧症治療剤「マシテンタン(オプスミットR錠)」のインパクト(共著)

    更科俊洋, 赤木 達, 中村一文

    PHARM STAGE   15 ( 5 )   35 - 39   2015

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  • 肺高血圧を伴う心房中隔欠損症例の経カテーテル閉鎖術の治療効果(共著)

    渡辺修久, 麻植浩樹, 赤木禎治, 更科俊洋, 高谷陽一, 木島康文, 赤木 達, 中村一文, 岡田 健, 伊藤 浩

    呼吸と循環   63 ( 8 )   S53-S54   2015

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  • ボセンタン継続例とアンブリセンタンへ変更例での治療効果の検討(共著)

    更科俊洋, 赤木 達, 麻植浩樹, 中村一文, 伊藤 浩

    呼吸と循環   63 ( 8 )   S42-S42   2015

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  • 循環器病の診断と治療に関するガイドライン(2008年度合同研究班報告)【ダイジェスト版】急性および慢性心筋炎の診断・治療に関するガイドライン(2009年改訂版)(共著)

    和泉 徹, 磯部光章, 河合祥雄, 川名正敏, 木村一雄, 許 俊鋭, 小玉 誠, 佐地 勉, 廣江道昭, 松崎益徳, 松森 昭, 森本紳一郎, 由谷親夫, 石井正浩, 猪又孝元, 奥村 謙, 倉林正彦, 友池仁暢, 今中(吉田)恭子, 植田初江, 大倉裕二, 岡本 洋, 佐藤 衛, 塩井哲雄, 高野博之, 寺崎文生, 中村一文, 中村浩士, 西尾亮介, 西川俊郎, 布田伸一, 矢崎善一, 吉川 勉, 山科 章, 吉村道博

    日本心臓血管外科学会雑誌   44 ( 5 )   1 - 9   2015

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  • Delivery of imatinib-incorporated nanoparticles into lungs suppresses the development of monocrotaline-induced pulmonary arterial hypertension(共著)

    Akagi S, Nakamura K, Miura D, Saito Y, Matsubara H, Ogawa A, Matoba T, Egashira K, Ito H

    Int Heart J   56 ( 3 )   354 - 359   2015

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  • Epoprostenol sodium for treatment of pulmonary arterial hypertension. International journal

    Yukihiro Saito, Kazufumi Nakamura, Satoshi Akagi, Toshihiro Sarashina, Kentaro Ejiri, Aya Miura, Aiko Ogawa, Hiromi Matsubara, Hiroshi Ito

    Vascular health and risk management   11   265 - 70   2015

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    The release of endogenous prostacyclin (PGI2) is depressed in patients with pulmonary arterial hypertension (PAH). PGI2 replacement therapy by epoprostenol infusion is one of the best treatments available for PAH. Here, we provide an overview of the current clinical data for epoprostenol. Epoprostenol treatment improves symptoms, exercise capacity, and hemodynamics, and is the only treatment that has been shown to reduce mortality in patients with idiopathic PAH (IPAH) in randomized clinical trials. We have reported that high-dose epoprostenol therapy (>40 ng/kg/min) also results in marked hemodynamic improvement in some patients with IPAH. High-dose epoprostenol has a pro-apoptotic effect on PAH-PASMCs via the IP receptor and upregulation of Fas ligand (FasL) in vitro. However, long-term intravenous administration of epoprostenol is sometimes associated with catheter-related infections and leads to considerable inconvenience for the patient. In the future, the development of new routes of administration or the development of powerful PGI2 analogs, IP-receptor agonists, and gene and cell-based therapy enhancing PGI2 production with new routes of administration is required.

    DOI: 10.2147/VHRM.S50368

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  • Effect of vildagliptin, a dipeptidyl peptidase 4 inhibitor, on cardiac hypertrophy induced by chronic beta-adrenergic stimulation in rats.(共著)

    Miyoshi T, Nakamura K, Yoshida M, Miura D, Oe H, Akagi S, Sugiyama H, Akazawa K, Yonezawa T, Wada J, Ito H

    Cardiovasc Diabetol.   13   43 - 43   2014

  • DPP-4 inhibitor and alpha-glucosidase inhibitor equally improve endothelial function in patients with type 2 diabetes: EDGE study.(共著)

    Nakamura K, Oe H, Kihara H, Shimada K, Fukuda S, Watanabe K, Takagi T, Yunoki K, Miyoshi T, Hirata K, Yoshikawa J, Ito H

    Cardiovasc Diabetol.   13   110 - 110   2014

  • Increased Passive Stiffness of Cardiomyocytes in the Transverse Direction and Residual Actin and Myosin Cross-bridge Formation in Hypertrophied Rat Hearts

    Kazufumi Nakamura, Hironobu Toda, Toru Miyoshi, Hiroshi Ito

    JOURNAL OF CARDIAC FAILURE   19 ( 10 )   S121 - S121   2013.10

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  • Increased Passive Stiffness of Cardiomyocytes in the Transverse Direction and Residual Actin and Myosin Cross-Bridge Formation in Hypertrophied Rat Hearts Induced by Chronic beta-Adrenergic Stimulation

    Wakako Sumita Yoshikawa, Kazufumi Nakamura, Daiji Miura, Juichiro Shimizu, Ken Hashimoto, Noriyuki Kataoka, Hiroko Toyota, Hiroshi Okuyama, Toru Miyoshi, Hiroshi Morita, Kengo Fukushima Kusano, Tatsuhito Matsuo, Miyako Takaki, Fumihiko Kajiya, Naoto Yagi, Tohru Ohe, Hiroshi Ito

    CIRCULATION JOURNAL   77 ( 3 )   741 - 748   2013.3

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    Background: Left ventricular (LV) hypertrophy is often present in patients with diastolic heart failure. However, stiffness of hypertrophied cardiomyocytes in the transverse direction has not been fully elucidated. The aim of this study was to assess passive cardiomyocyte stiffness of hypertrophied hearts in the transverse direction and the influence of actin-myosin cross-bridge formation on the stiffness.
    Methods and Results: Wistar rats received a vehicle (control) or isoproterenol (ISO) subcutaneously. After 7 days, compared with the controls, ISO administration had significantly increased heart weight and LV wall thickness and had decreased peak early annular relaxation velocity (e') assessed by echocardiography. Elastic modulus of living cardiomyocytes in the transverse direction assessed by an atomic force microscope was significantly higher in the ISO group than in controls. We added butanedione monoxime (BDM), an inhibitor of actin-myosin interaction, and blebbistatin, a specific myosin II inhibitor, to the medium. BDM and blebbistatin significantly reduced the elastic modulus of cardiomyocytes in the ISO group. X-ray diffraction analysis showed that the reflection intensity ratio (I-(1,I-0)/I-(1,I-1)) at diastole was not different before and after treatment with BDM, which induces complete relaxation, in control hearts, but that I-(1,I-0)/I-(1,I-1) was significantly increased after BDM treatment in the ISO group, indicating residual cross-bridge formation in hypertrophied hearts.
    Conclusions: Passive cardiomyocyte stiffness in the transverse direction is increased in hearts with ISO-induced hypertrophy and this is caused by residual actin-myosin cross-bridge formation. (Circ J 2013; 77: 741-748)

    DOI: 10.1253/circj.CJ-12-0779

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  • 新薬の最近の話題 イマチニブ

    中村 一文, 赤木 達, 伊藤 浩

    分子呼吸器病   17 ( 1 )   118 - 120   2013.3

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    Other Link: http://search.jamas.or.jp/link/ui/2013209013

  • SIGNIFICANCE OF IMIDAPRIL IN THE DIRECT INHIBITION OF MATRIX METALLOPROTEINASES IN EXPEIMENTAL ABDOMINAL AORTIC ANEURYSM; COMPARISON WITH LOSARTAN

    Toru Miyoshi, Kazufumi Nakamura, Hiroshi Morita, Kengo Kusano, Hiroshi Ito

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   59 ( 13 )   E2061 - E2061   2012.3

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  • 心臓からみた心腎連関 (特集 心腎連鎖の克服を目指した糖尿病腎症の治療) -- (心腎連関とは)

    中村 一文, 伊藤 浩

    糖尿病   4 ( 2 )   21 - 24   2012.2

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    Other Link: http://search.jamas.or.jp/link/ui/2012121177

  • Characteristics of pulmonary artery smooth muscle cells and endothelial cells in IPAH

    240 ( 1 )   36 - 40   2012.1

  • Treatment with Imatinib for Refractory IPAH

    60 ( 1 )   27 - 31   2012.1

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  • 肺動脈のreverse remodeling―肺高血圧症患者の肺動脈平滑筋細胞を用いた検討―

    中村一文, 赤木達, 小川愛子, 草野研吾, 伊藤浩

    日本心臓病学会誌   5 ( Supplement 1 )   140   2010.8

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  • 特発性肺動脈性肺高血圧症において高用量エポプロステノール療法は血行動態を著しく改善する

    赤木達, 中村一文, 小川愛子, 草野研吾, 宮地克維, 松原広己, 伊藤浩

    日本心臓病学会誌   5 ( Supplement 1 )   232   2010.8

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  • Drug-induced long QT syndrome

    Respiration and circulation   58 ( 5 )   511 - 516   2010.5

  • 肺動脈性肺高血圧症の病理学的特徴

    中村一文, 三浦綾, 由谷親夫

    循環器内科   67 ( 5 )   469 - 474   2010

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  • 分子標的治療薬 (imatinib) の肺高血圧症における効果

    小川愛子, 中村一文, 松原広己

    循環器内科   67 ( 5 )   525 - 529   2010

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  • Relationship between circulating levels of monocyte chemoattractant protein-1 and systolic dysfunction in patients with hypertrophic cardiomyopathy

    Jun Iwasaki, Kazufumi Nakamura, Hiromi Matsubara, Yoichi Nakamura, Nobuhiro Nishii, Kimikazu Banba, Masato Murakami, Keiko Ohta-Ogo, Hideo Kimura, Norihisa Toh, Satoshi Nagase, Takefumi Oka, Hiroshi Morita, Kengo Fukushima Kusano, Tohru Ohe

    CARDIOVASCULAR PATHOLOGY   18 ( 6 )   317 - 322   2009.11

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    Background: Progression of hypertrophic cardiomyopathy (HCM) to left ventricular dilatation and systolic dysfunction sometimes occurs. However, the mechanism of the transition from hypertrophy to dysfunction has not been elucidated. It has been reported that circulating levels of monocyte chemoattractant protein-1 (MCP-1), which is a major factor promoting the accumulation of macrophages, are increased in patients with congestive heart failure. We measured circulating levels of MCP-1 in patients with HCM and examined whether MCP-1 was expressed in the myocardium of HCM patients. We also examined whether circulating levels of MCP-1 were correlated with left ventricular dysfunction. Methods: Circulating levels of MCP-1 were measured by an enzyme immunoassay in 26 patients with HCM (60 2 years old) and 20 control subjects (57 2 years old). Cardiac function was evaluated by two-dimensional echocardiography and cardiac catheterization. Results: HCM patients had significantly elevated levels of MCP-1 (HCM: 309+/-30 vs. control: 178+/-8 pg/ml, P&lt;001). MCPI levels in patients with systolic dysfunction were significantly higher than those in patients without systolic dysfunction (P&lt;05) and were also significantly higher than those in patients with outflow obstruction (P&lt;05). Immunohistochemical analysis revealed that MCP-1 was expressed in endomyocardial biopsy samples obtained from HCM patients with systolic dysfunction. Furthermore, MCP-1 levels were inversely correlated with fractional shortening (r=-.4011, P&lt;05) and correlated with left ventricular end-diastolic pressure (r=-.579, P&lt;01). Conclusion: These results show that MCP-1 is associated with, and might be involved in the pathogenesis of, left ventricular systolic dysfunction in patients with HCM. (C) 2009 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.carpath.2008.12.004

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  • Application of Real-Time Three-Dimensional Transesophageal Echocardiography Using a Matrix Array Probe for Transcatheter Closure of Atrial Septal Defect

    Manabu Taniguchi, Teiji Akagi, Nobuhisa Watanabe, Yoshio Okamoto, Koji Nakagawa, Yasufumi Kijima, Norihisa Toh, Shinichi Ohtsuki, Kengo Kusano, Shunji Sano

    JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY   22 ( 10 )   1114 - 1120   2009.10

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    Background: The aim of this study was to demonstrate the utility of real-time three-dimensional (3D) transesophageal echocardiography (RT3D-TEE) using a matrix array 3D transesophageal echocardiographic probe for morphologic evaluation and guidance of transcatheter closure of atrial septal defects (ASDs).
    Methods: Forty-eight consecutive patients scheduled for the intervention were included. Two-dimensional (2D) transesophageal echocardiography (2D-TEE) and RT3D-TEE were performed before and during the procedures. Measurements of maximal ASD diameter and surrounding rims obtained on RT3D-TEE were compared with those obtained on 2D-TEE.
    Results: In 46 patients (96%), optimal 3D images for the morphologic evaluation of ASDs were obtained. RT3D-TEE facilitated the evaluation of ASD morphology and surrounding rims and was able to provide intra-procedural information clearly. A Bland-Altman plot showed a mean maximal diameter difference of -0.12 mm between the means (95% limits of agreement, -2.2 to 2.5 mm).
    Conclusion: RT3D-TEE is a clinically useful, complementary option to 2D-TEE for evaluation of ASD morphology and for interventional guidance. (J Am Soc Echocardiogr 2009; 22: 1114-20.)

    DOI: 10.1016/j.echo.2009.06.008

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  • 4-Hydroxy-2-nonenal Induces Calcium Overload via the Generation of Reactive Oxygen Species in Isolated Rat Cardiac Myocytes

    Kazufumi Nakamura, Daiji Miura, Kengo Fukushima Kusano, Yoshihisa Fujimoto, Wakako Sumita-Yoshikawa, Soichiro Fuke, Nobuhiro Nishii, Satoshi Nagase, Yoshiki Hata, Hiroshi Morita, Hiromi Matsubara, Tohru Ohe, Hiroshi Ito

    JOURNAL OF CARDIAC FAILURE   15 ( 8 )   709 - 716   2009.10

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    Background: It has been reported that that the amount of 4-hydroxy-2-nonenal (FINE), which is a major lipid peroxidation product and a cytotoxic aldehyde, is increased in the human failing myocardium. This study was designed to determine whether FINE has a pro-oxidant effect in cardiac myocytes and whether FINE causes Ca(2+) overload.
    Methods and Results: Exposure to FINE for 10 minutes in the presence of ferric nitrilotriacetate induced the production of hydroxyl radical (.OH) in the rat myocardium as assessed by electron spin resonance spectroscopy, and FINE induced the generation of reactive oxygen species (ROS) in a dose-dependent manner as assessed by 2&apos;, 7&apos;-dichlorofluorescein diacetate fluorescence. FINE increased intracellular Ca(2+) concentration ([Ca(2+)](i)) as assessed by fura-2 ratio in a dose- and time-dependent manner. After 20 minutes of FINE (400 mu mol/L) exposure, hypercontracture was induced in 67% of the cells. Catalase, an antioxidative enzyme that can decompose hydrogen peroxide (H(2)O(2)), significantly attenuated the increase in [Ca(2+)](i) and completely inhibited hypercontracture. Carvedilol, a beta-blocker with potent antioxidant activity, also significantly attenuated the increase in [Ca(2+)](i) and completely inhibited hypercontracture, but propranolol had no effect on either [Ca(2+)](i) increase or hypercontracture.
    Conclusions: FINE induces the formation of ROS, especially H(2)O(2) and .OH, in cardiomyocytes and subsequently ROS cause intracellular Ca(2+) overload. FINE formation may play an important role as a mediator of oxidative stress in heart failure. (J Cardiac Fail 2009;15:709-716)

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  • A novel KCNH2 mutation as a modifier for short QT interval

    Hideki Itoh, Tomoko Sakaguchi, Takashi Ashihara, Wei-Guang Ding, Iori Nagaoka, Yuko Oka, Yuko Nakazawa, Takenori Yao, Hikari Jo, Makoto Ito, Kazufumi Nakamura, Tohru Ohe, Hiroshi Matsuura, Minoru Horie

    INTERNATIONAL JOURNAL OF CARDIOLOGY   137 ( 1 )   83 - 85   2009.9

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    In a 34-year-old man showing short QT interval (QTc 329 ms), we identified a novel C-terminal KCNH2 mutation, R1135H. Using a heterologous expression system with CHO cells, the mutant channels were found to display a significantly slow deactivation, which resulted in a gain-of-function for reconstituted &apos;I(Kr)&apos; channels. This mutation could modify clinical phenotypes for this patient. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

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  • Abnormal transmural repolarization process in patients with Brugada syndrome

    Mutsuko Sangawa, Hiroshi Morita, Takaaki Nakatsu, Nobuhiro Nishii, Daiji Miura, Aya Miura, Takeshi Tada, Masato Murakami, Shigeki Hiramatsu, Satoshi Nagase, Kazufumi Nakamura, Takefumi Oka, Shinji Toyonaga, Keiichi Mashima, Shozo Kusachi, Kazuhide Yamamoto, Tohru Ohe, Kengo F. Kusano

    HEART RHYTHM   6 ( 8 )   1163 - 1169   2009.8

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    BACKGROUND Repolarization abnormality, especially during bradycardia, might be critical for initiation of ventricular fibrillation (VF) in patients with Brugada syndrome (BrS), but the contribution of the rate-dependent repolarization dynamics to the occurrence of VF is still unknown.
    OBJECTIVE The aim of our study was to determine the differences in rate-dependent repolarization dynamics between BrS with and without spontaneous VF and between BrS with and without SCN5A mutation.
    METHODS The subjects were 37 BrS patients with VF (VF(+) group: 10 mate subjects) and without VF (VF(-) group: 27 mate subjects) and 20 control subjects. Genetic analysis of SCN5A was performed in all 37 BrS patients. The relationships between QT, QTp, Tp-e, and RR intervals were obtained from Hotter recordings as first Linear regression tines, and the slopes of QT/RR, QTp/RR, and Tp-e/RR Linear regression Lines as the sensitivity of rate-dependent repolarization dynamics were compared.
    RESULTS QT/RR and Tp-e/RR slopes showed toss of a rate-dependent property in the VF(+) group compared with those in the VF(-) and control groups. There was no significant difference in QTp/RR slope among the VF(+), VF(-) and control groups. The Tp-e interval had a negative correlation with the RR interval in the VF(+) group and a positive correlation with the RR interval in the VF(-) and control groups. There was no significant difference in QT/RR, QTp/RR, and Tp-e/RR slopes. between BrS patients with SCN5A mutation and those without SCN5A mutation.
    CONCLUSIONS Loss of rate-dependent QT dynamics may be associated with occurrence of VF in BrS.

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  • Differential effects of cardiac sodium channel mutations on initiation of ventricular arrhythmias in patients with Brugada syndrome

    Hiroshi Morita, Satoshi Nagase, Daiji Miura, Aya Miura, Shigeki Hiramatsu, Takeshi Tada, Masato Murakami, Nobuhiro Nishii, Kazufumi Nakamura, Shiho T. Morita, Takefumi Oka, Kengo F. Kusano, Tohru Ohe

    HEART RHYTHM   6 ( 4 )   487 - 492   2009.4

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    BACKGROUND Premature ventricular contractions (PVCs) do not occur frequently but can induce ventricular fibrillation (VF) in patients with Brugada syndrome. The effect of SCN5A mutation on the onset of ventricular arrhythmias is unknown.
    OBJECTIVE The purpose of this study was to evaluate PVC morphology and onset of VF in patients with Brugada syndrome.
    METHODS Morphology of PVCs was evaluated by 12-lead ECG in 32 patients with Brugada syndrome. Patients had spontaneous ventricular arrhythmia (n = 17) or sodium channel blocker-induced ventricular arrhythmia (n = 19). Patients were classified into two groups according to the existence of SCN5A mutation (22 mutation negative, 10 mutation positive).
    RESULTS Patients without mutation often had PVCs of left bundle branch block (LBBB) morphology (82%), especially with inferior axis (77%). Patients with mutation had PVCs of both right bundle branch block (36%) and LBBB (64%) morphologies. Only two patients with mutation had PVCs of LBBB, inferior-axis morphology.
    CONCLUSION Patients without SCN5A mutation often had PVCs of LBBB, inferior-axis morphology, suggesting a right ventricular outflow tract origin. Patients with SCN5A mutations had PVCs that originated from both the right and left ventricles.

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  • Transcatheter Closure of Atrial Septal Defect in Elderly Patients With Permanent Atrial Fibrillation

    Manabu Taniguchi, Teiji Akagi, Shinichi Ohtsuki, Yoshio Okamoto, Yasuharu Tanabe, Nobuhisa Watanabe, Koji Nakagawa, Norihisa Toh, Kengo Kusano, Shunji Sano

    CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS   73 ( 5 )   682 - 686   2009.4

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    Objectives: The aim of this study is to evaluate the feasibility and efficacy of device closure of atrial septal defect (ASD) in elderly patients with permanent atrial fibrillation. Background: Little is known about the feasibility of device closure of ASD in those patients. Methods: Nine consecutive patients (mean age 68.1 years) with permanent atrial fibrillation (&gt;1 year persistent) underwent catheter closure using the Amplatzer septal occluder. Transthoracic echocardiography and plasma B-type natriuretic peptide (BNP) level were assessed before and at 24 hours; and 1, 3, and &gt;6 months after the closure. Before the procedure, appropriate dose of warfarin was used in all, diuretics was used in 8/9. Same amount of medications were continued after the procedure. Results: ASD could be closed in all (mean device size 27.3 mm) without hemodynamic and thromboembolic complications. New York Heart Association (NYHA) functional classification was significantly improved in all patients after device closure. No hemodynamic and thromboembolic complications were observed during the follow-up period (mean 10.6 months). Although permanent atrial fibrillation did not change in all after the procedure, resting heart rate decreased from 76.2 +/- 16.0 to 68.3 +/- 13.2 beats/min (P = 0.015). There was statistically significant improvement in right ventricular/left ventricular diameter ratio (1.08 +/- 0.16 to 0.73 +/- 0.10, P = 0.008) and plasma BNP level (183.7 +/- 90.5 to 94.6 +/- 47.4 pg/mL, P = 0.008) after &gt;6 months device closure. Conclusions: Even in the patients complicated with permanent fibrillation, transcatheter closure of ASD can contribute to symptomatic improvement as well as cardiac geometric remodeling. (C) 2009 Wiley-Liss, Inc.

    DOI: 10.1002/ccd.21870

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  • FRS-116 Frequency of Single Nucleotide Polymorphisms in Japanese Patients with Brugada Syndrome(FRS24,Novel Mechanisms of Ventricular Arrhythmia (A),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

    Miura Daiji, Nakamura Kazufumi, Morita Hiroshi, Miura Aya, Sumita Wakako, Taniyama Makiko, Iwasaki Jun, Urakawa Shigemi, Kimura Hideo, Banba Kimikazu, Watanabe Atsuyuki, Nishii Nobuhiro, Nagase Satoshi, Hata Yoshiki, Kusano Kengo, Ohe Tohru

    Circulation journal : official journal of the Japanese Circulation Society   73   169 - 169   2009.3

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  • FRS-023 Red Cell Distribution Width as a Prognostic Marker in Patients with Nonischemic Cardiomyopathy(FRS5,Novel Biomarkers in Heart Failure (M),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

    Kijima Yasufumi, Fuke Soichiro, Nishii Nobuhiro, Nagase Satoshi, Hata Yoshiki, Nakamura Kazufumi, Morita Hiroshi, Ohe Tohru, Kusano Kengo

    Circulation journal : official journal of the Japanese Circulation Society   73   140 - 141   2009.3

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  • PE-514 Red Blood Cell Distribution Width Reflects Heart Failure Status in Patients with Idiopathic Pulmonary Arterial Hypertension(PE086,Pulmonary Circulation (H),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)

    Fuke Soichiro, Nishii Nobuhiro, Nagase Satoshi, Nakamura Kazufumi, Hata Yoshiki, Morita Hiroshi, Ohe Tohru, Kusano Kengo

    Circulation journal : official journal of the Japanese Circulation Society   73   529 - 529   2009.3

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  • OE-151 Conduction Abnormality within QRS Complex Detected by Wavelet Transform of SAECG in Patients with Brugada Syndorme(OE26,Ventricular Arrhythmia (Clinical/Diagnosis/Treatment) (A),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

    Nosaka Kazumasa, Nishii Nobuhiro, Nagase Satoshi, Hata Yoshiki, Nakamura Kazufumi, Morita Hiroshi, Kusano Kengo

    Circulation journal : official journal of the Japanese Circulation Society   73   212 - 212   2009.3

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  • PE-246 Serum Cyctatin C Reflects Cardiac Diastolic Dysfunction in Patients with Heart Failure(PE042,Cardiac Function (Clinical) 2 (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

    Nosaka Kazumasa, Nishii Nobuhiro, Nagase Satoshi, Hata Yoshiki, Nakamura Kazufumi, Morita Hiroshi, Kusano Kengo

    Circulation journal : official journal of the Japanese Circulation Society   73   461 - 461   2009.3

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  • OE-198 Increased Cardiomyocyte Elasticity in the Transverse Direction in Hypertrophied Rat Hearts Induced by Chronic β-Adrenergic Stimulation(OE34,Cardiac Function (Basic) (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

    Nakamura Kazufumi, Sumita Wakako, Hashimoto Ken, Miura Daiji, Nishii Nobuhiro, Nagase Satoshi, Morita Hiroshi, Hata Yoshiki, Kusano Kengo, Ohe Tohru

    Circulation journal : official journal of the Japanese Circulation Society   73   223 - 223   2009.3

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  • PJ-608 Comparison of Clinical Characteristics between the Patients with Connective Tissue Disease and Idiopathic Pulmonary Arterial Hyptertension(PJ102,Pulmonary Circulation 2 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

    Hirota Minoru, Fuke Soichiro, Nishii Nobuhiro, Nagase Satoshi, Hata Yoshiki, Nakamura Kazufumi, Morita Hiroshi, Ohe Tohru, Kusano Kengo

    Circulation journal : official journal of the Japanese Circulation Society   73   698 - 699   2009.3

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  • DPJ-006 Differential Effects of Genotype on the Initiation of Ventricular Arrhythmia in Patients with Brugada Syndrome(DPJ01,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 1 (A),Digital Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

    Morita Hiroshi, Miura Daiji, Nagase Satoshi, Hata Yoshiki, Nakamura Kazufumi, Kusano Kengo, Ohe Tohru

    Circulation journal : official journal of the Japanese Circulation Society   73   377 - 377   2009.3

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  • Simvastain Inhibits Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells from Patients with Idiopathic Pulmonary Arterial Hypertension

    中村一文

    分子心血管病   10 ( 3 )   96 - 97   2009

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  • 無症候性Brugada症候群におけるEPSの適応-岡山大学での適応の変遷-(共著)

    森田 宏, 草野研吾, 永瀬 聡, 西井伸洋, 多田 毅, 村上正人, 平松茂樹

    Japanese Journal of Electrocardiology   29 ( 4 )   S-4-50-S-4-55   2009

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  • Intravenous Amiodarone in Patients with Ventricular Tachycardia/Fibrillation Resistant to Nifekalant

    KUSANO Kengo F., NAKAGAWA Koji, TADA Takeshi, NAGASE Satoshi, NAKAMURA Kazufumi, MORITA Hiroshi, NISHII Nobuhiro, FUKE Soichiro, HATA Yoshiki, OHE Tohru

    Japanese Journal of Electrocardiology   29 ( 1 )   26 - 33   2009

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    Language:Japanese   Publisher:The Japanese Society of Electrocardiology  

    DOI: 10.5105/jse.29.26

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    Other Link: http://search.jamas.or.jp/link/ui/2009129025

  • エポプロステノール治療による血管病変へのアプローチ(共著)

    松原広己, 赤木 達, 中村一文, 佐久間聖仁, 京谷晋吾

    PROGRESS IN MEDICINE   29 ( 2 )   529 - 534   2009

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  • Effects of combined treatment with angiotensin II type 1 receptor blocker and statin on stent restenosis.(共著)

    Yoshikawa M, Nakamura K, Nagase S, Sakuragi S, Kusano KF, Matsubara H

    J Cardiovasc Pharmacol.   53 ( 2 )   179 - 186   2009

  • 非Brugada型特発性心室細動12例の検討(原著)

    平松茂樹, 森田 宏, 中川晃志, 田中正道, 村上正人, 多田 毅, 西井伸洋, 永瀬 聡

    心臓   41 ( 3 )   54 - 60   2009

  • 心臓MRIにて遅延造影を認め電気生理検査で伝導遅延所見を認めたBrugada症候群の1例(共著)

    永瀬 聡, 多田 毅, 西井伸洋, 村上正人, 平松茂樹, 宮地晃平, 三浦大志, 中村一文, 森田 宏, 岡 岳文, 草野研吾, 大江 透

    臨床心臓電気生理   32   265 - 272   2009

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  • 酸化ストレスと拡張機能障害(共著)

    谷山真規子, 中村一文

    医学のあゆみ   231 ( 8 )   815 - 817   2009

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  • 治療(2)】急性心筋炎における大量免疫グロブリン療法-有効性は確かか?(共著)

    柚木 佳, 中村一文

    心臓   41 ( 11 )   1201 - 1204   2009

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    有効性は確かか?

    DOI: 10.11281/shinzo.41.1201

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  • 後天性にBrugada型心電図を呈した5例(共著)

    森田 宏, 西井伸洋, 永瀬 聡, 中村一文, 幡 芳樹, 草野研吾

    Journal of Arrhythmia   25   333   2009

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  • 長期間のDDD pacingで左室流出路圧較差が改善した閉塞性肥大型心筋症の1例(共著)

    高谷陽一, 西井伸洋, 永瀬 聡, 幡 芳樹, 中村一文, 森田 宏, 草野研吾

    Journal of Arrhythmia   25   343   2009

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  • 家族内集積を認めた左室緻密化障害を合併した完全房室ブロックの1例(共著)

    野坂和正, 西井伸洋, 永瀬 聡, 幡 芳樹, 中村一文, 森田 宏, 草野研吾

    Journal of Arrhythmia   25   484   2009

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  • 特別座談会企画「大規模臨床試験から何を学か」大規模臨床試験が語ること(共著)

    草野研吾, 中村一文, 前島洋平

    血圧   16 ( 1 )   9 - 14   2009

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  • 「心不全と不整脈」心不全をめぐる最近の話題

    中村一文

    メディカル・ビューポイント   31 ( 1 )   2   2009

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  • 肺動脈性肺高血圧症における肺動脈平滑筋細胞の特性(共著)

    赤木 達, 小川愛子, 中村一文

    血栓と循環   17 ( 3 )   263 - 268   2009

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  • 薬剤負荷心電図で診断されたカテコラミン誘発性多形性心室頻拍の1例(共著)

    木島康文, 平松茂樹, 多田 毅, 村上正人, 西井伸洋, 永瀬 聡, 幡 芳樹, 中村一文, 森田 宏, 草野研吾

    Journal of Arrhythmia   25   499   2009

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  • Fulminant eosinophilic myocarditis associated with visceral larva migrans caused by Toxocara canis infection(共著)

    Enko K, Tada T, Ohgo KO, Nagase S, Nakamura K, Ohta K, Ichiba S, Ujike Y, Nawa Y, Maruyama H, Ohe T, Kusano KF

    Circ J   73 ( 7 )   1344 - 1348   2009

  • Spironolactone and Chlorthalidone in Uncontrolled Elderly Hypertensive Patients Treated with Calcium Antagonists and Angiotensin II Receptor-Blocker: Effects on Endothelial Function, Inflammation, and Oxidative Stress

    Hiroshi Yamanari, Kazufumi Nakamura, Daiji Miura, Shuichi Yamanari, Tohru Ohe

    CLINICAL AND EXPERIMENTAL HYPERTENSION   31 ( 7 )   585 - 594   2009

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    The side effects of thiazide-type diuretics include metabolic abnormality and increased oxidative stress, which might cause endothelial dysfunction despite blood pressure reduction. In hypertensive patients with heart failure, treatment with an aldosterone antagonist resulted in improvements in endothelial function and significant blood pressure reduction. The purpose of the present study was to evaluate the differences between spironolactione and chlorthalidone in hypertensive elderly patients treated with calcium antagonists and angiotensin II receptor blockers.
    Fourteen uncontrolled hypertensive patients treated with amlodipine and candesartan were included in this study. The study was an open-label randomized crossover comparison of 16 weeks treatment with spironolactone against chlorthalidone added to amlodipine and candesartan. blood pressure significantly decreased in patients treated with both spironolactone and chlorthalidone. Chlortalidone reduced flow-mediated dilation significantly compared to the baseline condition and spironolactone. serum highsensitively C-reactive protein and uric acid increased significantly in chlorthalidone-treated patients compared to spironolactonetreated patients. We conclude that spironolactone may be a more useful add-on therapy than chlorthalidone in hypertensive patients inadequately controlled on candesartan and amlodipine, because spironolactone preserves endothelial function and reduces inflammation compared to chlorthalidone.

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  • Are adrenergic receptor blockers effective or contraindicated in pulmonary arterial hypertension?(共著)

    Nakamura K, Fujio H

    Circ J.   73 ( 12 )   2212 - 2213   2009

  • 植込み型除細動器植込み術時における除細動閾値テストの心機能に与える影響についての検討(共著)

    杜 徳尚, 西井伸洋, 森田 宏, 谷口 学, 永瀬 聡, 中村一文, 草野研吾

    Journal of Arrhythmia   25   407   2009

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  • 非虚血性心筋症に伴う心室頻拍に対するカテーテル・アブレーションの検討(共著)

    永瀬 聡, 村上正人, 平松茂樹, 多田 毅, 西井伸洋, 中村一文, 幡 芳樹, 森田 宏, 草野研吾, 大江 透

    Journal of Arrhythmia   25   221   2009

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  • 急性心筋炎に伴う多剤抵抗性心室頻拍に対してアミオダロン静注が有効であった乳児の1例

    中川晃志, 細木信吾, 伴場主一, 多田 毅, 西井伸洋, 永瀬 聡, 中村一文, 幡 芳樹, 森田 宏, 草野研吾, 大江透

    PROGRESS IN MEDICINE   29   609 - 613   2009

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  • 心室細動の一次予防に植込み型除細動器植込み術を施行した筋強直性ジストロフィーの1例(共著)

    尾上 豪, 西井伸洋, 永瀬 聡, 中村一文, 幡 芳樹, 森田 宏, 草野研吾

    Journal of Arrhythmia   25   406   2009

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  • QT延長を伴わないNifekalantによる心室頻拍の催不整脈作用を認めた1例(共著)

    川合晴朗, 森田 宏, 西井伸洋, 永瀬 聡, 幡 芳樹, 中村一文, 草野研吾

    Journal of Arrhythmia   25   524   2009

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  • ミトコンドリア心筋症に複数の副伝導路を認めアブレーションにて根治し得た1例(共著)

    田中正道, 木島康文, 多田 毅, 村上正人, 平松茂樹, 西井伸洋, 永瀬 聡, 中村一文, 幡 芳樹, 森田 宏, 草野研吾, 由谷親夫, 大江 透

    Journal of Arrhythmia   25   287   2009

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  • 症候性Brugada症候群におけるSCN5A遺伝子異常とベプリジルの有用性の関連についての検討(共著)

    村上正人, 多田 毅, 平松茂樹, 西井伸洋, 永瀬 聡, 幡 芳樹, 中村一文, 森田 宏, 草野研吾

    Journal of Arrhythmia   25   292   2009

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  • 植込み型除細動器を植込まれたBrugada症候群患者における適切作動, 不適切作動の検討(共著)

    西井伸洋, 森田 宏, 中川晃志, 田中正道, 平松茂樹, 多田 毅, 村上正人, 永瀬 聡, 中村一文, 幡 芳樹, 草野研吾

    Journal of Arrhythmia   25   293   2009

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  • Brugada症候群の再分極異常とVF発症との関連性の検討(共著)

    寒川睦子, 中津高明, 豊永慎二, 間島圭一, 森田 宏, 西井伸洋, 三浦大志, 多田 毅, 村上正人, 平松茂樹, 永瀬 聡, 中村一文, 幡 芳樹, 草野研吾, 草地省蔵, 大江 透

    Journal of Arrhythmia   25   376   2009

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  • Radial augmentation index associated with increase in B-type natriuretic peptide in patients with hypertension

    Satoru Sakuragi, Takeshi Maruo, Manabu Taniguchi, Satoshi Nagase, Kazufumi Nakamura, Kengo Fukushima Kusano, Tohru Ohe

    INTERNATIONAL JOURNAL OF CARDIOLOGY   130 ( 3 )   414 - 419   2008.11

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    Brain natriuretic peptide (BNP) level has been used as a marker of left ventricular (LV) systolic dysfunction (LVSD), even though some patients with atherosclerosis have a high BNP level irrespective of LV function. In this study, we investigate whether augmentation index (AI), which is an index of wave reflection, is involved in increasing BNP level in hypertensive patients without LVSD. Sixty treated hypertensive patients were enrolled in this study. Radial AI (r-AI) was measured in all patients. The patients were classified into tertiles on the basis of r-AI to identify the characteristics of the patients with a high r-AI.
    BNP level was significantly higher in the patients classified into the highest tertile of r-AI. In echocardiography, e &apos;, which is index of left ventricular (LV) diastolic function, decreased and LV mass index (LVMI) increased gradually with r-AI, whereas there was no difference in LV ejection fraction ( LVEF). r-AI significantly correlated with LVMI (r=0.35, p &lt; 0.01) and e &apos; (r=-0.30, p &lt; 0.05). In univariate analysis, age, heart rate, r-AI, LVEF, e &apos; and LVMI were significantly correlated with BNP level, whereas multivariate analysis demonstrated that only r-AI and LVEF correlated with BNP level. In conclusion, an increase in r-AI was significantly associated with an increase in BNP level in hypertensive patients without LVSD. LV hypertrophy and diastolic dysfunction associated with increase in r-AI may be involved in increase in BNP level. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.ijcard.2007.08.129

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  • 119) 右房内に巨大血栓を認めた一例(第92回日本循環器学会中国・四国合同地方会)

    森 あい子, 川田 哲史, 永瀬 聡, 中村 一文, 森田 宏, 武田 賢治, 岡 岳文, 草野 研吾, 大江 透, 佐野 俊二, 豊永 慎二

    Circulation journal : official journal of the Japanese Circulation Society   72   1042 - 1042   2008.10

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  • 85) SLEに伴う重症二次性肺高血圧が正常化した一例(第92回日本循環器学会中国・四国合同地方会)

    廣田 稔, 草野 研吾, 赤木 達, 福家 聡一郎, 永瀬 聡, 中村 一文, 森田 宏, 岡 岳文, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   72   1038 - 1038   2008.10

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  • 171) Pergolide投与中に僧帽弁閉鎖不全による心不全を呈した1例(第92回日本循環器学会中国・四国合同地方会)

    杉山 洋樹, 武田 賢治, 永瀬 聡, 中村 一文, 岡 岳文, 草野 研吾, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   72   1048 - 1048   2008.10

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  • 157) AED(自動体外式除細動器)の有効性と限界(第92回日本循環器学会中国・四国合同地方会)

    尾上 豪, 森田 宏, 永瀬 聡, 中村 一文, 岡 岳文, 草野 研吾, 大江 透, 氏家 良人

    Circulation journal : official journal of the Japanese Circulation Society   72   1046 - 1046   2008.10

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  • 50) 両心不全の原因が全身性硬化症による二次性心筋症であると考えられた一症例(第92回日本循環器学会中国・四国合同地方会)

    野坂 和正, 草野 研吾, 尾上 豪, 福家 聡一郎, 永瀬 聡, 中村 一文, 森田 宏, 武田 賢治, 岡 岳文, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   72   1034 - 1034   2008.10

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  • Longer repolarization in the epicardium at the right ventricular outflow tract causes type 1 ECG in patients with Brugada syndrome

    NAGASE Satoshi, FUKUSHIMA KUSANO Kengo, MORITA Hiroshi, NISHII Nobuhiro, HIRAMATSU Shigeki, NAKAMURA Kazufumi, OHE Tohru

    28 ( 5 )   428 - 428   2008.10

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  • Update on genetic analysis in Brugada syndrome

    Daiji Miura, Kazufumi Nakamura, Tohru Ohe

    HEART RHYTHM   5 ( 10 )   1495 - 1496   2008.10

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    DOI: 10.1016/j.hrthm.2008.07.026

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  • Fragmented QRS as a Marker of Conduction Abnormality and a Predictor of Prognosis of Brugada Syndrome

    Hiroshi Morita, Kengo F. Kusano, Daiji Miura, Satoshi Nagase, Kazufumi Nakamura, Shiho T. Morita, Tohru Ohe, Douglas P. Zipes, Jiashin Wu

    CIRCULATION   118 ( 17 )   1697 - 1704   2008.10

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    Background-Conduction abnormalities serve as a substrate for ventricular fibrillation (VF) in patients with Brugada syndrome (BS). Signal-averaged electrograms can detect late potentials, but the significance of conduction abnormalities within the QRS complex is still unknown. The latter can present as multiple spikes within the QRS complex (fragmented QRS [f-QRS]). We hypothesized that f-QRS could indicate a substrate for VF and might predict a high risk of VF for patients with BS.
    Methods and Results-In study 1, we analyzed the incidence of f-QRS in 115 patients with BS (13 resuscitated from VF, 28 with syncope, and 74 asymptomatic). f-QRS was observed in 43% of patients, more often in the VF group (incidence of f-QRS: VF 85%, syncope 50%, and asymptomatic 34%, P &lt; 0.01). SCN5A mutations occurred more often in patients with f-QRS (33%) than in patients without f-QRS (5%). In patients with syncope or VF, only 6% without f-QRS experienced VF during follow-up (43 +/- 25 months), but 58% of patients with f-QRS had recurrent syncope due to VF (P &lt; 0.01). In study 2, to investigate the mechanism of f-QRS, we studied in vitro models of BS in canine right ventricular tissues (n = 4) and optically mapped multisite action potentials. In the experimental model of BS, ST elevation resulted from a large phase 1 notch of the action potential in the epicardium, and local epicardial activation delay reproduced f-QRS in the transmural ECG.
    Conclusions-f-QRS appears to be a marker for the substrate for spontaneous VF in BS and predicts patients at high risk of syncope. (Circulation. 2008; 118: 1697-1704.)

    DOI: 10.1161/CIRCULATIONAHA.108.770917

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  • Expression of monocyte chemoattractant protein-1 in idiopathic dilated cardiomyopathy

    Makoto Kobayashi, Kazufumi Nakamura, Kengo Fukushima Kusano, Yoichi Nakamura, Keiko Ohta-Ogo, Satoshi Nagase, Satoru Sakuragi, Tohru Ohe

    INTERNATIONAL JOURNAL OF CARDIOLOGY   126 ( 3 )   427 - 429   2008.6

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    Immunological factors have been involved in the pathogenesis of dilated cardiomyopathy (DCM). The cytotoxic action of macrophages is one of the main factors causing cardiac myocyte damage. Monocyte chemoattractant protein-1 (MCP-1) is a major signal for the accumulation of monocytes/macrophages. We examined whether MCP-1 was expressed in the myocardium of DCM patients and whether the expression level was correlated with the degree of impairment of cardiac function. The expression of MCP-1 in the myocardium was determined by immunohistochemistry in endomyocardial biopsy samples from 13 patients. The expression of MCP-1 was found in all myocardial samples from DCM patients but not in those from control subjects. Positive staining for MCP-1 was distinct in cardiac myocytes, interstitium and infiltrating cells. Semi-quantitative analysis revealed that the expression of MCP-1 was inversely correlated with left ventricular ejection fraction. In conclusion, the expression level of MCP-1 in the myocardium was correlated with the degree of impairment of cardiac function in patients with DCM. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

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  • Repolarization heterogeneity in the right ventricular outflow tract: Correlation with ventricular arrhythmias in Brugada patients and in an in vitro canine Brugada model

    Hiroshi Morita, Douglas P. Zipes, Kengo Fukushima-Kusano, Satoshi Nagase, Kazufumi Nakamura, Shiho T. Morita, Tohru Ohe, Jiashin Wu

    HEART RHYTHM   5 ( 5 )   725 - 733   2008.5

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    BACKGROUND Brugada syndrome (BrS) is characterized by repolarization abnormality with ST-segment elevation in the right ventricular outflow tract (RVOT).
    OBJECTIVE Although action potential (AP) heterogeneity is associated with induction of ventricular arrhythmias (VA) in BrS, clinical evidence and its experimental correlations are still absent and are the focus of this study.
    METHODS We evaluated repolarization heterogeneity in 15 patients with BrS using body surface mapping and in 8 pairs of isolated canine RVOT and right ventricular anteroinferior (RVAI) preparations having drug-induced BrS using optical mapping.
    RESULTS Patients had large J-ST-segment elevation and long QT interval in the RVOT at baseline. Administration of pilsicainide (1 mg/kg) exaggerated J-ST-segment elevation, caused simultaneous Long and short QT intervals in the RVOT, and induced polymorphic ventricular tachycardia (VT) and T wave alternans (TWA). Dispersion of QT within the RVOT after pilsicainide was greater in patients that had syncope or ventricutar fibrillation than those that did not. Ventricular arrhythmias originated from the RVOT along with local electrocardiogram changes and TWA. Repolarization heterogeneity was much Less in areas outside the RVOT. Inducing BrS increased AP heterogeneity (with and without spike-and-dome) within the RVOT epicardium. Phase 2 reentry and TWA originated from the epicardium in 88% and 50% of RVOT preparations, respectively. In contrast, the RVOT endocardium and RVAI had Little AP heterogeneity, with neither reentry nor TWA.
    CONCLUSION The instability and heterogeneity of repolarization within the epicardium of the RVOT seem to be associated with arrhythmogenesis in both patients and in the in vitro tissue models of BrS.

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  • 50) メキシレチン投与によりQT間隔延長が著明に軽減した先天性QT延長症候群の一例(第91回日本循環器学会中国地方会)

    尾上 豪, 福家 聡一郎, 岡 岳文, 永瀬 聡, 中村 一文, 草野 研吾, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   72   954 - 954   2008.4

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  • 85) 部分的肺静脈還流異常に原発性肺高血圧症を合併した一例(第91回日本循環器学会中国地方会)

    森 あい子, 草野 研吾, 圓光 賢希, 杉山 洋樹, 永瀬 聡, 中村 一文, 森田 宏, 岡 岳文, 福 康志, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   72   958 - 958   2008.4

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  • 44) 洞不全症候群を合併した無症候性ブルガダ心電図の一症例(第91回日本循環器学会中国地方会)

    多田 毅, 草野 研吾, 永瀬 聡, 西井 伸洋, 宮地 晃平, 平松 茂樹, 村上 正人, 中村 一文, 森田 宏, 岡 岳文, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   72   954 - 954   2008.4

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  • 61) 精巣摘出によりBrugada型心電図が消失した心筋ナトリウムチャネル遺伝子変異を有する一例(第91回日本循環器学会中国地方会)

    森田 宏, 草野 研吾, 三浦 大志, 永瀬 聡, 中村 一文, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   72   956 - 956   2008.4

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  • 7) 入浴中にST上昇・VFを来たしたことが捉えられたBrugada症候群の一例(第91回日本循環器学会中国地方会)

    野坂 和正, 草野 研吾, 田中 正道, 福家 聡一郎, 永瀬 聡, 中村 一文, 武田 賢治, 岡 岳文, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   72   950 - 950   2008.4

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  • 41) 左心耳起源心房頻拍に対しnon-contact mapping法を用いてablationを行った一例(第91回日本循環器学会中国地方会)

    宮地 晃平, 永瀬 聡, 村上 正人, 多田 毅, 平松 茂樹, 西井 伸洋, 中村 一文, 森田 宏, 岡 岳文, 草野 研吾, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   72   953 - 953   2008.4

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  • 54) 重複僧帽弁口を伴った孤立性左室緻密化障害にWPW症候群を合併した一例(第91回日本循環器学会中国地方会)

    福家 聡一郎, 中川 晃志, 谷口 学, 渡辺 敦之, 永瀬 聡, 中村 一文, 森田 宏, 岡 岳文, 草野 研吾, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   72   955 - 955   2008.4

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  • 60) 失神原因精査に携帯型イベントホルター心電図が有用であった発作性完全房室ブロックの1例(第91回日本循環器学会中国地方会)

    山脇 均, 福家 聡一郎, 武田 賢治, 岡 岳文, 永瀬 聡, 中村 一文, 草野 研吾, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   72   955 - 955   2008.4

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  • OE-381 Clinical Features of and Effects of Angiotensin System Antagonists on Amiodarone-Induced Pulmonary Toxicity(Arrhythmia, therapy(04)(A),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

    Nikaido Akira, Kusano Kengo, Morita Hiroshi, Nakamura Kazufumi, Oka Takefumi, Nagase Satoshi, Nishii Nobuhiro, Fuke Soichiro, Enkoh Kenki, Ohe Tohru

    Circulation journal : official journal of the Japanese Circulation Society   72   276 - 276   2008.3

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  • PJ-745 Clinical Usefulness of the Non-invasive Stroke Volume Measurement System, the Task Force[○!R] Monitor, in Patients with Pulmonary Hypertension(Pulmonary circulation(04)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

    Fuke Soichiro, Kusano Kengo, Mizoguchi Hiroki, Nagase Satoshi, Nakamura Kazufumi, Morita Hiroshi, Oka Takefumi, Ohe Tohru

    Circulation journal : official journal of the Japanese Circulation Society   72   699 - 699   2008.3

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  • OJ-008 Usefulness of the Hot-Bath Test in Brugada Sydrome(Arrhythmia, diagnosis/ Pathophysiology/ EPS(03)(A),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

    Mori Aiko, Tanaka Masamichi, Kusano Kengo, Nosaka Kazumasa, Nakagawa Koji, Sugiyama Hiroki, Yamawaki Hitoshi, Onoue Go, Fuke Soichiro, Nagase Satoshi, Nakamura Kazufumi, Morita Hiroshi, Takeda Kenji, Oka Takefumi, Ohe Tohru

    Circulation journal : official journal of the Japanese Circulation Society   72   289 - 290   2008.3

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  • OJ-011 Characteristics and Diagnosis of Patients with Inherited Bidirectional Ventricular Tachycardia(Arrhythmia, diagnosis/ Pathophysiology/ EPS(03)(A),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

    Sugiyama Hiroki, Morita Hiroshi, Takeda Kenji, Nagase Satoshi, Nakamura Kazufumi, Oka Takefumi, Kusano Kengo, Ohe Tohru

    Circulation journal : official journal of the Japanese Circulation Society   72   290 - 290   2008.3

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  • OJ-007 Blunted QT Prolongation to Sudden R-R Prolongation in Brugada Syndrome Patients with Coved ST Elevation(Arrhythmia, diagnosis/ Pathophysiology/ EPS(03)(A),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

    Tada Takeshi, Kusano Kengo, Nagase Satoshi, Nishii Nobuhiro, Hiramatsu Shigeki, Miyaji Kohei, Murakami Masato, Tanaka Masamichi, Nakagawa Koji, Miura Daiji, Nakamura Kazufumi, Morita Hiroshi, Oka Takefumi, Ohe Tohru

    Circulation journal : official journal of the Japanese Circulation Society   72   289 - 289   2008.3

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  • OJ-056 Outcome After Implantable Cardioverter-Defibrillator in Brugada Syndrome(Arrhythmia, therapy(06)(A),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

    Nishii Nobuhiro, Kusano Kengo, Miyaji Kohei, Hiramatsu Shigeki, Tada Takeshi, Murakami Masato, Nagase Satoshi, Nakamura Kazufumi, Morita Hiroshi, Oka Takefumi, Ohe Tohru, Miura Daiji, Miura Aya

    Circulation journal : official journal of the Japanese Circulation Society   72   301 - 301   2008.3

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  • FRS-106 Fragmented QRS, a Marker of Intraventricular Conduction Abnormality and Predictor of Prognosis of Brugada Syndrome(New Horizon in Diagnosis and Pathophysiology of Arrhythmia(A),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

    Morita Hiroshi, Kusano Kengo, Miura Daiji, Nagase Satoshi, Nakamura Kazufumi, Oka Takefumi, Wu Jiashin, Zipes Douglas P, Ohe Tohru

    Circulation journal : official journal of the Japanese Circulation Society   72   172 - 173   2008.3

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  • 6 Anti-KCNH2 Antibody-induced Long QT Syndrome : Novel Acquired Form of LQT Syndrome(Plenary Session 4 (PL-4) (A) New Scientific Approaches to QT Prolongation,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

    Nakamura Kazufumi, Katayama Yusuke, Morita Hiroshi, Kusano Kengo, Ohe Tohru

    Circulation journal : official journal of the Japanese Circulation Society   72   20 - 20   2008.3

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  • Longer repolarization in the epicardium at the right ventricular outflow tract causes type 1 electrocardiogram in patients with Brugada syndrome

    Satoshi Nagase, Kengo Fukushima Kusano, Hiroshi Morita, Nobuhiro Nishii, Kimikazu. Banba, Atsuyuki Watanabe, Shigeki Hiramatsu, Kazufumi Nakamura, Satoru Sakuragi, Tohru Ohe

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   51 ( 12 )   1154 - 1161   2008.3

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    Objectives We examined the relationship between repolarization abnormality and coved-type ST-segment elevation with terminal inverted T-wave (type 1 electrocardiogram [ECG]) in patients with Brugada syndrome (BrS).
    Background Recent experimental studies have suggested that accentuation of the right ventricular action potential (AP) notch preferentially prolongs epicardial AP causing inversion of the T-wave.
    Methods In 19 patients with BrS and 3 control subjects, activation-recovery intervals (ARIs) and repolarization times (RTs) in the epicardium and endocardium were directly examined with the use of local unipolar electrograms at the right ventricular outflow tract. Surface ECG, ARI, and RT were examined before and after administration of pilsicainide.
    Results Type 1 ECG was observed in 10 of the 19 BrS patients before the administration of pilsicainide and in all of the 19 patients after the administration of pilsicainide. We found that ARI and RT in the epicardium were shorter than those in the endocardium in all 9 BrS patients without type 1 ECG under baseline conditions and in all control subjects regardless of pilsicainide administration. However, longer epicardial ARI than endocardial ARI was observed in 8 of the 10 BrS patients manifesting type 1 ECG under baseline conditions and in all of the BrS patients after the administration of pilsicainide. Also, epicardial RT was longer than endocardial RT in all patients manifesting type 1 ECG regardless of pilsicainide administration.
    Conclusions Our data provide support for the hypothesis that the negative T-wave associated with type 1 BrS ECG is due to a preferential prolongation of the epicardial AP secondary to accentuation of the AP notch in the region of the right ventricular outflow tract.

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  • Atrial fibrillation in patients with Brugada syndrome - Relationships of gene mutation, electrophysiology, and clinical backgrounds

    Kengo F. Kusano, Makiko Tamyama, Kazufumi Nakamura, Daiji Miura, Kimikazu Banba, Satoshi Nagase, Hiroshi Morita, Nobuhlro Nishil, Atsuyuki Watanabe, Takeshi Tada, Masato Murakarm, Kohei Miyaji, Shigeki Hiramatsu, Koji Nakagawa, Masamichi Tanaka, Aya Miura, Hideo Kimura, Soichiro Fuke, Wakako Sumita, Satoru Sakuragi, Shigern Urakawa, Jun Iwasaki, Tohru Ohe

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   51 ( 12 )   1169 - 1175   2008.3

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    Objectives The goal of our work was to examine the relationships of atrial fibrillation (AF) with genetic, clinical, and electrophysiological backgrounds in Brugada syndrome (BrS).
    Background Atrial fibrillation is often observed in patients with BrS and indicates that electrical abnormality might exist in the atrium as well as in the ventricle. SCN5A, a gene encoding the cardiac sodium channel, has been reported to be causally related to BrS. However, little is known about the relationships of atrial arrhythmias with genetic, clinical, and electrophysiological backgrounds of BrS.
    Methods Seventy-three BrS patients (49 +/- 12 years of age, men/women = 72/1) were studied. The existence of SCN5A mutation and clinical variables (syncopal episode, documented ventricular fibrillation [VF], and family history of sudden death) were compared with spontaneous AF episodes. Genetic and clinical variables were also compared with electrophysiologic (EP) parameters: atrial refractory period, interatrial conduction time (CT), repetitive atrial firing, and AF induction by atrial extra-stimulus testing.
    Results Spontaneous AF occurred in 10 (13.7%) of the BrS patients and SCN5A mutation was detected in 15 patients. Spontaneous AF was associated with higher incidence of syncopal episodes (60.0% vs. 22.2%, p &lt; 0.03) and documented VF (40.0% vs. 14.3%, p &lt; 0.05). SCN5A mutation was associated with prolonged CT (p &lt; 0.03) and AF induction (p &lt; 0.05) in EP study, but not related to the spontaneous AF episode and other clinical variables. In patients with documented VF, higher incidence of spontaneous AF (30.8% vs. 10.0%, p &lt; 0.05), AF induction (53.8% vs. 20.0%, p &lt; 0.03), and prolonged CT was observed.
    Conclusions Spontaneous AF and VF are closely linked clinically and electrophysiologically in BrS patients. Patients with spontaneous AF have more severe clinical backgrounds in BrS. SCN5A mutation is associated with electrical abnormality but not disease severity.

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  • Clinical significance of macroscopic T-wave alternans after sodium channel blocker administration in patients with Brugada syndrome

    Takeshi Tada, Kengo Fukushima Kusano, Satoshi Nagase, Kimikazu Banba, Daiji Miura, Nobuhiro Nishii, Atsuyuki Watanabe, Kazufumi Nakamura, Hiroshi Morita, Tohru Ohe

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   19 ( 1 )   56 - 61   2008.1

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    Clinical Significance of Macroscopic T-Wave Alternans. Introduction: Macroscopic T-wave alternans (TWA) is sometimes observed after sodium channel blocker administration in patients with Brugada syndrome (BS), but little is known about the association between occurrence of TWA and clinical characteristics in BS patients. We investigated the association between spontaneous ventricular fibrillation (VF) occurrence and TWA after pilsicainide, a sodium channel blocker administration in BS patients.
    Methods and Results: We administered pilsicainide at a dose of 1 mg/kg to 77 BS patients (76 males and one female; mean age, 48.4 years) and examined the association between TWA after pilsicainide administration and clinical characteristics, including age, spontaneous VF, syncope, family history of sudden death, spontaneous coved ST elevation, late potentials (LP), induction of VF by programmed electrical stimulation, and SCN5A mutation. None of the patients had TWA before pilsicainide administration, but TWA became apparent in 17 (22.1%) of the patients after pilsicainide administration. Patients with TWA had a significantly higher incidence of spontaneous VF (52.9% vs 8.3%, P &lt; 0.001) and syncope (58.8% vs 26.7%, P &lt; 0.05) than did patients without TWA. Then, we focused on the association between spontaneous VF and clinical characteristics. Patients with spontaneous VF had a significantly higher incidence of TWA (64.3% vs 12.7%, P &lt; 0.001) and LP positive (92.9% vs 56.5%, P &lt; 0.01) than did patients without spontaneous VF. In multivariate analysis, TWA (P = 0.001) and LP (P = 0.047) appeared as the independent predictor for spontaneous VF.
    Conclusion: TWA after pilsicainide administration is associated with a high risk of clinical VF in patients with BS.

    DOI: 10.1111/j.1540-8167.2007.00967.x

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  • Clinical features of and effects of angiotensin system antagonists on amiodarone-induced pulmonary toxicity.

    Nikaido A, Tada T, Nakamura K, Murakami M, Banba K, Nishii N, Fuke S, Nagase S, Sakuragi S, Morita H, Ohe T, Kusano KF

    Int J Cardiol   2008

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  • A novel KCNH2 mutation as a modifier for short QT interval.

    Itoh H, Sakaguchi T, Ashihara T, Ding WG, Nagaoka I, Oka Y, Nakazawa Y, Yao T, Jo H, Ito M, Nakamura K, Ohe T, Matsuura H, Horie M

    Int J Cardiol   2008

  • 特集 致死性不整脈をきたす疾患-診断と治療-特殊な機序によるQT延長症候群-HERGチャネルに対する自己抗体.

    杉山洋樹, 中村一文, 大江 透, 片山祐介

    Heart View   12 ( 9 )   1117 - 1121   2008

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  • 抗KCNH2抗体による自己免疫性QT延長症候群-後天性QT延長症候群の新しい発症機序-

    中村一文, 片山祐介, 大江 透

    循環器専門医   16 ( 2 )   231 - 236   2008

  • シンポジウム:肺高血圧症に対する経口治療薬の位置づけと最新の知見5 肺動脈性肺高血圧症治療における最新の知見.

    松原広己, 宮地克維, 赤木 達, 中村一文

    Therapeutic Research   29 ( 10 )   1780 - 1782   2008

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  • 頻回な心室性不整脈を呈したBrugada症候群に対する低用量Isoproterenolの治療効果の検討

    渡邊敦之, 草野研吾, 森田宏, 三浦大二, 角田和歌子, 平松茂樹, 伴場主一, 西井伸洋, 永瀬聡, 中村一文, 桜木悟, 大江透

    岡山医学会雑誌   12 ( 9 )   95 - 99   2008

  • Topics 心不全の基礎と臨床 酸化ストレスと心不全.

    中村一文

    循環器フォーラム2008 心不全Up-to-date記録集   2 - 3   2008

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  • 座談会 心不全と不整脈 心不全患者の不整脈をどう治療するか.

    大江 透, 鵜野起久也, 栗田隆志, 庄田守男, 中村一文

    不整脈News&Views   26   3 - 9   2008

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  • シンポジウム:肺高血圧症に対する経口治療薬の位置づけと最新の知見5 肺動脈性肺高血圧症治療における最新の知見.

    松原広己, 宮地克維, 赤木 達, 中村一文

    Therapeutic Research   29 ( 10 )   1780 - 1782   2008

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  • Altered nano/micro-order elasticity of pulmonary artery smooth muscle cells of patients with idiopathic pulmonary arterial hypertension.

    Nakamura K, Shimizu J, Kataoka N, Hashimoto K, Ikeda T, Fujio H, Ohta-Ogo K, Ogawa A, Miura A, Mohri S, Nagase S, Morita H, Kusano KF, Date H, Matsubara H, Mochizuki S, Hashimoto K, Kajiya F, Ohe T

    Int J Cardiol   2008

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  • Arterial Stiffening is Associated with Exercise Intolerance and Hyperventilatory Response in Patients with Coronary Artery Disease.

    Enko K, Sakuragi S, Kakishita M, Ohkawa K, Nagase S, Nakamura K, Kusano KF, Ohe T

    Cardiology   2   41 - 48   2008

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  • Usefulness of a long-straight sheath for atrial lead insertion at the right atrial septum.

    Nishii N, Kusano KF, Miyaji K, Hiramatsu S, Tada T, Murakami M, Banba K, Sakai Y, Nagase S, Nakamura K, Sakuragi S, Ohe T

    Circ J   72 ( 2 )   262 - 267   2008

  • 28.?? Topics 心不全の基礎と臨床 酸化ストレスと心不全.

    中村一文

    循環器フォーラム2008 心不全Up-to-date記録集   2 - 3   2008

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  • 163)治療抵抗性の原発性肺高血圧症に対しSildenafil併用が著効した成人男性の一例(第90回日本循環器学会中国・四国合同地方会)

    中川 晃志, 田中 正道, 多田 毅, 永瀬 聡, 中村 一文, 櫻木 悟, 草野 研吾, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   71   975 - 975   2007.10

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  • 50)不整脈源性右室心筋症と診断されていた心サルコイドーシスの一例(第90回日本循環器学会中国・四国合同地方会)

    小倉 可奈子, 草野 研吾, 二階堂 暁, 大郷 恵子, 福家 聡一郎, 西井 伸洋, 永瀬 聡, 中村 一文, 桜木 悟, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   71   962 - 962   2007.10

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  • 107)CRT-Dを施行した修正大血管転位症(C-TGA)の一例(第90回日本循環器学会中国・四国合同地方会)

    圓光 賢希, 草野 研吾, 岡 岳文, 西井 伸洋, 永瀬 聡, 中村 一文, 桜木 悟, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   71   969 - 969   2007.10

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  • 196)拡張相肥大型心筋症に合併した難治性心室頻拍に対し開胸下cryoablationを行った一例(第90回日本循環器学会中国・四国合同地方会)

    二階堂 暁, 草野 研吾, 福家 聡一郎, 西井 伸洋, 永瀬 聡, 中村 一文, 桜木 悟, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   71   979 - 979   2007.10

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  • 161)PH crisisに対してNO吸入で対応し,緊急生体肺移植を行った原発性肺高血圧症の1例(第90回日本循環器学会中国・四国合同地方会)

    岡 岳文, 円光 賢希, 溝口 博喜, 永瀬 聡, 中村 一文, 桜木 悟, 草野 研吾, 伊達 洋至, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   71   975 - 975   2007.10

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  • 160)心房中隔欠損症の肺高血圧合併患者で,epoprostenol治療中にカテーテル感染からBOOP様経過をたどった一例(第90回日本循環器学会中国・四国合同地方会)

    福家 聡一郎, 草野 研吾, 小倉 加奈子, 赤木 達, 溝口 博喜, 永瀬 聡, 中村 一文, 桜木 悟, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   71   975 - 975   2007.10

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  • Relationship between arrhythmogenesis and disease activity in cardiac sarcoidosis

    Kimikazu Banba, Kengo Fukushima Kusano, Kazufumi Nakamura, Hiroshi Morita, Aiko Ogawa, Fuyo Ohtsuka, Keiko Ohta Ogo, Nobuhiro Nishii, Atsuyuki Watanabe, Satoshi Nagase, Satoru Sakuragi, Tohru Ohe

    HEART RHYTHM   4 ( 10 )   1292 - 1299   2007.10

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    BACKGROUND In patients with cardiac sarcoidosis, ventricular arrhythmias and/or conduction disturbances are frequently observed and sometimes fatal. However, few reports on disease activity and arrhythmic events in cardiac sarcoidosis are available.
    OBJECTIVE The purpose of this study was to investigate the relationship between disease activity and arrhythmic events in cardiac sarcoidosis and the effect of corticosteroid therapy.
    METHODS The study population consisted of 15 cardiac sarcoidosis patients with new-onset symptomatic arrhythmia, including eight patients admitted once for complete atrioventricular block (CAVB), five patients admitted once for sustained ventricular tachycardia (VT), and two patients admitted twice for two arrhythmic events (one for CAVB and the other for sustained VT). Disease activity was evaluated by gallium-67 citrate (Ga) scintigraphy. All patients with positive Ga uptake were treated with corticosteroids, and arrhythmic events were evaluated by repeat Hotter recordings.
    RESULTS Positive uptake of Ga was observed in 8 (80%) of the 10 CAVB events and in 1 (14%) of the 7 sustained VT events (80% vs 14%, P =.02). Corticosteroids abolished myocardial Ga uptake in all nine patients with positive Ga uptake. After corticosteroid therapy was started, AV conduction improved in 5 of 9 CAVB patients (including 8 patients with new-onset CAVB and one patient with history of CAVB). However, ventricular arrhythmias were not improved after corticosteroid therapy.
    CONCLUSION In cardiac sarcoidosis patients, CAVB develops mainly during the active phase of the disease. Early treatment with corticosteroids might improve AV conduction disturbance. However, sustained VT is not closely linked with disease activity and frequently develops in the advanced stage of disease.

    DOI: 10.1016/j.hrthm.2007.06.006

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  • Anti-KCNH2 antibody-induced long QT syndrome: Novel acquired form of long QT syndrome

    Kazufumi Nakamura, Yusuke Katayama, Kengo F. Kusano, Kayo Haraoka, Yoshinori Tani, Satoshi Nagase, Hiroshi Morita, Daiji Miura, Yoshihisa Fujimoto, Tetsushi Furukawa, Kazuo Ueda, Yoshiyasu Aizawa, Akinori Kimura, Yoshihisa Kurachi, Tohru Ohe

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   50 ( 18 )   1808 - 1809   2007.10

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    DOI: 10.1016/j.jacc.2007.07.037

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  • T75M-KCNJ2 mutation causing Andersen-Tawil syndrome enhances inward rectification by changing Mg2+ sensitivity

    Yoshinori Tani, Daiji Miura, Junko Kurokawa, Kazufumi Nakamura, Mamoru Ouchida, Kenji Shimizu, Tohru Ohe, Tetsushi Furukawa

    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY   43 ( 2 )   187 - 196   2007.8

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    Andersen-Tawil syndrome (ATS) is a multisystem inherited disease exhibiting periodic paralysis, cardiac arrhythmias, and dysmorphic features. In this study, we characterized the KCNJ2 channels with an ATS mutation (T75M) which is associated with cardiac phenotypes of bidirectional ventricular tachycardia, syncope, and QT(c) prolongation. Confocal imaging of GFP-KCNJ2 fusion proteins showed that the T75M mutation impaired membrane localization of the channel protein, which was restored by co-expression of WT channels with T75M channels. Whole-cell patch-clamp experiments in CHO-K1 cells showed that the T75M mutation produced a loss-of-function of the channel. When both WT and the T75M were co-expressed, the T75M mutation showed dominant-negative effects on inward rectifier K+ current densities, with prominent suppression of outward currents at potentials between 0 mV and + 80 mV over the E-K. Inside-out patch experiments in HEK293T cells revealed that co-expression of WT and the T75M channels enhanced voltage-dependent block of the channels by internal Mg2+, resulting in enhanced inward rectification at potentials 50 mV more positive than the EK. We suggest that the T75M mutation causes dominant-negative suppression of the co-expressed WT KCNJ2 channels. In addition, the T75M mutation caused alteration of gating kinetics of the mutated KCNJ2 channels, i.e., increased sensitivity to intracellular Mg2+ and resultant enhancement of inward rectification. The data presented suggest that the mutation may influence clinical features, but it does not directly show this. (c) 2007 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.yjmcc.2007.05.005

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  • The role of autonomic nervous activity on arrhythmogenesis of Brugada syndrome

    SANGAWA Mutsuko, NAKATSU Takaaki, TOYONAGA Shinji, MASHIMA Keiichi, KUSACHI Shozo, WATANABE Atsuyuki, BANBA Kimikazu, NISHII Nobuhiro, TADA Takeshi, NAGASE Satoshi, MORITA Hiroshi, NAKAMURA Kazufumi, KUSANO Kengo, OHE Tohru

    44 ( 3 )   156 - 165   2007.6

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  • 71)WPW症候群を合併した家族性肥大型心筋症の一例(第89回日本循環器学会中国地方会)

    赤木 達, 大田 恵子, 中川 晃志, 多田 毅, 永瀬 聡, 中村 一文, 桜木 悟, 草野 研吾, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   71   858 - 858   2007.4

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  • 36)心臓再同期療法後より頻発する心室頻拍に対し高周波カテーテルアブレーションを施行した一例(第89回日本循環器学会中国地方会)

    二階堂 暁, 酒井 芳昭, 赤木 進, 福家 聡一郎, 西井 伸洋, 永瀬 聡, 中村 一文, 桜木 悟, 草野 研吾, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   71   854 - 854   2007.4

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  • 89)原発性肺高血圧症の心房中隔欠損合併例にepoprostenolを導入した2症例(第89回日本循環器学会中国地方会)

    福家 聡一郎, 二階堂 暁, 圓光 賢希, 赤木 達, 溝口 博喜, 永瀬 聡, 中村 一文, 桜木 悟, 草野 研吾, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   71   860 - 860   2007.4

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  • 68)ステロイド投与が有用であった好酸球性心筋炎の一症例(第89回日本循環器学会中国地方会)

    圓光 賢希, 桜木 悟, 大郷 恵子, 永瀬 聡, 中村 一文, 草野 研吾, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   71   857 - 857   2007.4

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  • 3)ヒト冠動脈平滑筋細胞におけるPioglitazoneの効果 : 遊走・増殖・活性酸素発生の抑制効果の検討(第89回日本循環器学会中国地方会)

    吉川 昌樹, 中村 一文, 永瀬 聡, 桜木 悟, 草野 研吾, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   71   850 - 850   2007.4

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  • FRS-087 Relationship between SCN5A Mutation and Atrial Vulnerability in Brugada Syndrome(Arrhythmia (clinical) ; Pathophysiology of Atrial Fibrillation, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

    Taniyama Makiko, Kusano Kengo, Banba Kimikazu, Morita Hiroshi, Nishii Nobuhiro, Watanabe Atsuyuki, Miura Daiji, Sumida Wakako, Iwasaki Jun, Urakawa Shigemi, Kimura Hideo, Miura Aya, Kobayashi Kaoru, Nagase Satoshi, Nakamura Kazufumi, Ohe Toru

    Circulation journal : official journal of the Japanese Circulation Society   71   141 - 141   2007.3

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  • 救命しえた劇症型好酸球性心筋炎の1例

    大郷恵子, 圓光賢希, 草野研吾, 櫻木 悟, 永瀬 聡, 中村一文, 柳井広之, 大森昌子, 大家政志, 難波靖治, 津田佳穂, 大江 透

    心臓   39 ( 3 )   112 - 117   2007

  • 心不全(下)-最新の基礎・臨床研究の進歩-XXIII 心不全での合併症-成因・病態・治療- 不整脈 心不全に用いられる抗不整脈薬

    中村一文, 西井伸洋, 大江 透

    日本臨床   65 ( 5 )   369 - 374   2007

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  • Efficacy and safety of the additional bepridil treatment in patients with atrial fibrillation refractory to class I antiarrhythmic drugs.

    Miyaji K, Tada H, Fukushima Kusano K, Hashimoto T, Kaseno K, Hiramatsu S, Tadokoro K, Naito S, Nakamura K, Oshima S, Taniguchi K, Ohe T

    Circ J   71 ( 8 )   1250 - 1257   2007

  • 異常Purkinje線維の興奮と多源性心室性不整脈の発生機序に関し検討を行った特発性心室細動の1例

    伴場主一, 草野研吾, 永瀬 聡, 西井伸洋, 渡邊敦之, 平松茂樹, 多田 毅, 村上正人, 大郷恵子, 酒井芳昭, 中村一文, 櫻木 悟, 大江 透

    臨床心臓電気生理   30   237 - 245   2007

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  • 原発性肺高血圧症の進行メカニズムの解明と治療薬の開発

    小川愛子, 中村一文, 松原広己, 藤尾栄起, 池田哲也, 宮地克維, 三浦大志, 三浦 綾, 永瀬 聡, 草野研吾, 伊達洋至, 大江 透

    岡山医学会雑誌   118 ( 3 )   187 - 192   2007

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    Other Link: http://ousar.lib.okayama-u.ac.jp/47268

  • 循環器症候群(第2版)Ⅰ-その他の循環器疾患を含めて-Ⅲ. 不整脈 二次性QT延長症候群

    原岡佳代, 中村一文, 大江 透

    別冊日本臨床 新領域別症候群シリーズ   4   221 - 224   2007

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  • イオン感応性電界効果トランジスタ(ISFET)を用いた迅速・簡便な細胞活性測定システムの開発

    合田 典子, 中村 通宏, 山本 尚武, 中村 一文

    中谷電子計測技術振興財団 年報   21   53 - 57   2007

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  • Aldosterone synthesis and cytokine production in human peripheral blood mononuclear cells

    Ryuzea Miura, Kazufumi Nakamura, Daiji Miura, Aya Miura, Kenichi Hisamatsu, Masahito Kajiya, Katsushi Hashimoto, Satoshi Nagase, Hiroshi Morita, Kengo Fukushima Kusano, Tetsuro Emori, Kazuhiko Ishihara, Tohru Ohe

    JOURNAL OF PHARMACOLOGICAL SCIENCES   102 ( 3 )   288 - 295   2006.11

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    Previously, we reported that spironolactone reduced cytokine production in cultured human peripheral blood mononuclear cells (PBMCs) with angiotensin (Ang) II stimulation. To address the mechanisms underlying this effect, we examined the contribution of aldosterone to cytokine production in cultured human PBMCs with Ang II stimulation. PBMCs expressed the messenger RNA (mRNA) of Ang II type I receptor (ATIR) and mineralocorticoid receptor (MR) both spontaneously and after Ang II stimulation, but expressed Ang II type 2 receptor (AT2R) under neither condition. After 24 h of incubation, exogenous Ang II induced the expression of CYP11B2 (a key enzyme of aldosterone synthesis) mRNA and caused aldosterone synthesis. CV-11974 (an AT1R antagonist) reduced Ang II-induced aldosterone synthesis, whereas PD-123319 (an AT2R antagonist) had no effect. The concentration of aldosterone peaked earlier than those of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha). After 48 h of incubation (under the influence of synthesized aldosterone), CV-11974 and spironolactone significantly reduced the Ang II-enhanced production of MCP-1 and TNF-alpha, whereas PD-123319 also had no effect. In conclusion, Ang II induces aldosterone synthesis through AT1R and enhances cytokine production through an AT1R-dependent mechanism and, at least partly, through a MR-dependent mechanism in human PBMCs.

    DOI: 10.1254/jphs.FP0060801

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  • 188)Narrow QRSに対し心臓再同期療法を施行した2症例(第88回日本循環器学会中国・四国合同地方会)

    西井 伸洋, 草野 研吾, 多田 毅, 大田 恵子, 村上 正人, 平松 茂樹, 渡辺 敦之, 伴場 主一, 永瀬 聡, 中村 一文, 桜木 悟, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   70   1169 - 1169   2006.10

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  • 142)肥大型心筋症患者の収縮不全における酸化ストレスによるDNA傷害の関与(第88回日本循環器学会中国・四国合同地方会)

    木村 英夫, 中村 一文, 永瀬 聡, 桜木 悟, 草野 研吾, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   70   1165 - 1165   2006.10

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  • 136)デスミン蓄積が原因と考えられた拡張型心筋症の一例(第88回日本循環器学会中国・四国合同地方会)

    大郷 恵子, 多田 毅, 草野 研吾, 酒井 芳昭, 伴場 主一, 西井 伸洋, 渡辺 敦之, 平松 茂樹, 永瀬 聡, 中村 一文, 桜木 悟, 由谷 親夫, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   70   1164 - 1164   2006.10

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  • 66)異常Purkinje線維の興奮が不整脈発生に関与したshort-coupled variant of torsades de pointesの一症例(第88回日本循環器学会中国・四国合同地方会)

    伴場 主一, 永瀬 聡, 西井 伸洋, 渡辺 敦之, 村上 正人, 多田 毅, 大田 恵子, 酒井 芳昭, 中村 一文, 桜木 悟, 草野 研吾, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   70   1156 - 1156   2006.10

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  • 78)左上肺静脈局所起源発作性心房頻拍が心房細動の発生,維持に関係した一例(第88回日本循環器学会中国・四国合同地方会)

    酒井 芳昭, 伴場 主一, 西井 伸洋, 平松 茂樹, 渡辺 敦之, 村上 正人, 永瀬 聡, 桜木 悟, 中村 一文, 草野 研吾, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   70   1157 - 1157   2006.10

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  • Anti-inflammatory effect of spironolactone on human peripheral blood mononuclear cells

    Ryuzea Miura, Kazufumi Nakamura, Daiji Miura, Aya Miura, Kenichi Hisamatsu, Masahito Kajiya, Satoshi Nagase, Hiroshi Morita, Kengo Fukushima Kusano, Tohru Ohe, Kazuhiko Ishihara

    JOURNAL OF PHARMACOLOGICAL SCIENCES   101 ( 3 )   256 - 259   2006.7

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    We evaluated the effect of alacepril, CV-11974, and spironolactone on the production of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) in cultured human peripheral blood mononuclear cells stimulated with angiotensin (Ang) II. Alacepril, CV-11974, and spironolactone significantly reduced the enhanced production of MCP-1 and TNF-alpha induced by exogenous Ang II. Specifically, 10 mu M of spironolactone significantly reduced cytokine production, compared to the same dose of alacepril or CV-11974. These findings indicate that spironolactone may contribute to ameliorate the prognosis of patients with cardiovascular diseases by reducing Ang II-induced inflammation, although further exploration including determining the mechanisms would be required.

    DOI: 10.1254/jphs.SC0060049

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  • Low-dose isoproterenol for repetitive ventricular arrhythmia in patients with Brugada syndrome

    A Watanabe, KF Kusano, H Morita, D Miura, W Sumida, S Hiramatsu, K Banba, N Nishii, S Nagase, K Nakamura, S Sakuragi, T Ohe

    EUROPEAN HEART JOURNAL   27 ( 13 )   1579 - 1583   2006.7

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    Aims Arrhythmic storm or repetitive ventricular arrhythmia (VA) has been occasionally observed in Brugada syndrome (BS). A beta-adrenergic stimulator [isoproterenol (ISP)] has been reported to suppress this arrhythmic storm in sporadic cases. Accordingly, we investigated the antiarrhythmic effects of ISP infusion in consecutive BS patients with arrhythmic storm or repetitive VA.
    Methods and results Seven BS patients with arrhythmic storm were studied. Intravenous ISP was administered as a bolus injection (1-2 mu g), followed by continuous infusion (0.15 mu g/min). Arrhythmic storm or repetitive VA was suppressed immediately after the bolus administration of ISP, which was followed by continuous infusion of low-dose ISP for 1-3 days. In all patients, ST-elevation decreased in right precordial leads. In six of the seven patients, VA subsided after the discontinuance of ISP. RR interval was shortened and ST-elevation in right precordial leads was decreased after ISP bolus injection. ST-elevation in right precordial leads remained decreased during continuous ISP infusion, whereas the RR interval returned to the control level.
    Conclusion Continuous administration of low-dose ISP may be effective for the suppression of repetitive VA occurrence in patients with BS.

    DOI: 10.1093/eurheartj/ehl060

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  • 特発性肺動脈高血圧症に対するスタチンの効果

    池田哲也, 中村一文, 小川愛子, 三浦大志, 永瀬聡, 桜木悟, 草野研吾, 大江透, 伊達洋至, 松原広己, 藤尾栄起

    Circ J   70 ( Supplement 2 )   1077   2006.4

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  • 246)自己免疫機序による慢性心筋炎が病因と考えられた左室機能不全の一例(第87回日本循環器学会中国・四国合同地方会)

    大郷 恵子, 多田 毅, 三浦 綾, 永瀬 聡, 中村 一文, 桜木 悟, 草野 研吾, 大江 透, 由谷 親夫

    Circulation journal : official journal of the Japanese Circulation Society   70   1078 - 1078   2006.4

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  • 90) Brugada症候群におけるSCN5A遺伝子の変異と電気生理学的検査における検討(第87回日本循環器学会中国・四国合同地方会)

    伴場 主一, 草野 研吾, 中村 一文, 永瀬 聡, 三浦 大志, 平松 茂樹, 西井 伸洋, 渡辺 敦之, 岩崎 淳, 浦川 茂美, 谷山 真規子, 角田 和歌子, 三浦 綾, 桜木 悟, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   70   1061 - 1061   2006.4

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  • 92) Pilsicainide負荷時の高位肋間のみでBrugada型心電図を呈したSCN5A異常を有する1例(第87回日本循環器学会中国・四国合同地方会)

    平松 茂樹, 渡辺 敦之, 西井 伸洋, 伴場 主一, 三浦 大志, 永瀬 聡, 中村 一文, 草野 研吾, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   70   1061 - 1061   2006.4

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  • 88)左室起源リエントリ性心室頻拍にて発見されたSCN5A遺伝子変異を認めるBrugada症候群の一例(第87回日本循環器学会中国・四国合同地方会)

    酒井 芳昭, 永瀬 聡, 平松 茂樹, 西井 伸洋, 伴場 主一, 渡辺 敦之, 細木 信吾, 三浦 大志, 谷山 真規子, 木村 英夫, 岩崎 淳, 浦川 茂美, 角田 和歌子, 三浦 綾, 中村 一文, 桜木 悟, 草野 研吾, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   70   1060 - 1060   2006.4

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  • 59)β刺激薬負荷で誘発された冠攣縮性狭心症の一例(第87回日本循環器学会中国・四国合同地方会)

    三宅 智博, 和田 匡史, 細木 信吾, 永瀬 聡, 中村 一文, 桜木 悟, 草野 研吾, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   70   1057 - 1057   2006.4

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  • 94)多種類の薬剤が心室性不整脈の抑制に有効であったAndersen症候群の2例(第87回日本循環器学会中国・四国合同地方会)

    和田 匡史, 永瀬 聡, 細木 信吾, 多田 毅, 村上 正人, 溝口 博喜, 大郷 恵子, 伴場 主一, 酒井 芳昭, 中村 一文, 櫻木 悟, 草野 研吾, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   70   1061 - 1061   2006.4

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  • PJ-157 Changes of Late Potentials after Administration of Sodium Channel Blocker in Brugada Syndrome(ECG/Body surface potential mapping/Holter-6 () PJ27,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

    Watanabe Atsuyuki, Kusano Kengo, Hiramatsu Shigeki, Tada Takeshi, Murakami masato, Banba Kimikazu, Nishii Nobuhiro, Hosogi Shingo, Nagase Satoshi, Nakamura Kazufumi, Morita Hiroshi, Sakuragi Satoru, Ohe Toru

    Circulation journal : official journal of the Japanese Circulation Society   70   528 - 528   2006.3

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  • Brugada Syndrome(Morning Lecture 9 (ML9) (A),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

    Kusano Kengo, Kusano Kengo F., Nagase Satoshi, Morita Hiroshi, Nishii Nobuhiro, Banba Kimikazu, Nakamura Kazufumi, Sakuragi Satoru, Ohe Tohru

    Circulation journal : official journal of the Japanese Circulation Society   70   100 - 100   2006.3

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  • PE-598 Detection of T Wave Abnormality in Brugada Syndrome : Usefulness of Vector Electrocardiograms and Body Surface Mapping(ECG/Body surface potential mapping/Holter-4 (A) PE60,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

    Hiramatsu Shigeki, Kusano Kengo, Murakami Masato, Tada Takeshi, Watanabe Atsuyuki, Banba Kimikazu, Nishii Nobuhiro, Hosogi Shingo, Nagase Satoshi, Nakamura Kazufumi, Morita Hiroshi, Sakuragi Satoru, Ohe Toru

    Circulation journal : official journal of the Japanese Circulation Society   70   424 - 424   2006.3

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  • 肺動脈性肺高血圧症の診断・治療と経過の検討

    小川愛子, 草野研吾, 松原広己, 宮地克維, 永瀬聡, 中村一文, 桜木悟, 伊達洋至, 大江透

    日本内科学会雑誌   95   179   2006.2

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  • KCNJ2の遺伝子変異を認めるAndersen症候群 (LQT7) における心臓電気生理学的検討.

    永瀬 聡, 柚木 佳, 三浦大志, 吉田賢司, 西井伸洋, 伴場主一, 中村一文, 斎藤博則, 草野研吾, 大江 透

    臨床心臓電気生理   29,257-264   2006

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  • Carvedilol inhibits proliferation of cultured pulmonary artery smooth muscle cells of patients with idiopathic pulmonary arterial hypertension.

    Fujio H, Nakamura K, Matsubara H, Kusano KF, Miyaji K, Nagase S, Ikeda T, Ogawa A, Ohta-Ogo K, Miura D, Miura A, Miyazaki M, Date H, Ohe T

    J Cardiovasc Pharmacol   2006

  • 特集/薬物によるQT延長の諸問題:遺伝子からICHまで 6. 後天性QT延長症候群の臨床的特徴.

    草野研吾, 中村一文, 大江 透

    臨床薬理   37,4,227-230   2006

  • 冠動脈造影により診断できた若年発症心室細動の2症例.

    伴場主一, 草野研吾, 永瀬 聡, 平松茂樹, 宮地晃平, 木村英夫, 西井伸洋, 中村一文, 桜木 悟, 大江 透

    心臓   38,3,105-111   2006

  • 心機能低下例における不整脈の薬物療法-上流治療ならびに抗不整脈薬の効果-

    中村一文, 岩崎 淳

    医学のあゆみ   218,14,1213-1216   2006

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  • SCN5A遺伝子変異を有するBrugada症候群の心電図および電気生理学的特徴-ピルジカイニド負荷試験を中心に-

    伴場主一, 草野研吾, 中村一文, 永瀬 聡, 渡邊敦之, 西井伸洋, 三浦大志, 森田 宏, 櫻木 悟, 大江 透

    Japanese Journal of Electrocardiology   26,4,S-4-97-S-4-101   2006

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  • Elevated levels of oxidative DNA damage in serum and myocardium of patients with heart failure.

    Kono Y, Nakamura K, Kimura H, Nishii N, Watanabe A, Banba K, Miura A, Nagase S, Sakuragi S, Kusano KF, Matsubara H, Ohe T

    Circulation Journal   2006

  • 特論 致死的不整脈への対応.

    村上正人, 中村一文, 大江 透

    日本臨床   64,5,985-989   2006

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  • サイファーステント留置後, 再狭窄をきたした1症例(第86回日本循環器学会中国地方会)

    吉川 昌樹, 細木 信吾, 武 寛, 永瀬 聡, 中村 一文, 齋藤 博則, 草野 研吾, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   69   907 - 907   2005.10

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  • SCN5A遺伝子に異常を認めた Brugada 症候群-LQT3の2症例(第86回日本循環器学会中国地方会)

    吉田 賢司, 柚木 佳, 三浦 大志, 木村 英夫, 平松 茂樹, 渡辺 敦之, 伴場 主一, 西井 伸洋, 永瀬 聡, 中村 一文, 齋藤 博則, 草野 研吾, 大江 透, 宮地 晃平

    Circulation journal : official journal of the Japanese Circulation Society   69   910 - 910   2005.10

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  • 巨大MACの一例(第86回日本循環器学会中国地方会)

    杜 徳尚, 村上 正人, 谷口 学, 丸尾 健, 永瀬 聡, 中村 一文, 齋藤 博則, 草野 研吾, 大江 透, 宮地 克維

    Circulation journal : official journal of the Japanese Circulation Society   69   914 - 914   2005.10

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  • 原発性肺高血圧症 (PPH) と特発性血小板減少性紫斑病 (ITP) を合併した一例(第86回日本循環器学会中国地方会)

    溝口 博喜, 谷口 学, 宮地 克維, 藤尾 栄起, 小川 愛子, 中村 一文, 齋藤 博則, 草野 研吾, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   69   915 - 915   2005.10

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  • T波の oversensing によるICD誤作動を繰り返した1例(第86回日本循環器学会中国地方会)

    村上 正人, 宮地 剛, 角田 和歌子, 西井 伸洋, 永瀬 聡, 中村 一文, 齋藤 博則, 草野 研吾, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   69   911 - 911   2005.10

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  • 心房細動に対して, 電気的 substarate ablation を行った2症例(第86回日本循環器学会中国地方会)

    武 寛, 西井 伸洋, 永瀬 聡, 草野 研吾, 村上 正人, 溝口 博喜, 谷口 学, 平松 茂樹, 渡辺 敦之, 伴場 主一, 中村 一文, 齋藤 博則, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   69   910 - 910   2005.10

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  • 急性心筋炎後心室頻拍の乳児に対してアミオダロン持続静注が極めて有効であった1症例(第86回日本循環器学会中国地方会)

    細木 信吾, 永瀬 聡, 中村 一文, 齋藤 博則, 草野 研吾, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   69   911 - 911   2005.10

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  • Equivalence of flow velocities through bilateral pulmonary vein anastomoses in bilateral living-donor lobar lung transplantation

    K Miyaji, H Matsubara, K Nakamura, KF Kusano, K Goto, H Date, T Ohe

    JOURNAL OF HEART AND LUNG TRANSPLANTATION   24 ( 7 )   860 - 864   2005.7

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    Background: Intraoperative transesophageal echocardiography (TEE) during lung transplantation is useful for monitoring cardiac condition and pulmonary vascular anastomoses to detect vascular complications, but the parameters for evaluation by TEE during lung transplantation have not been established.
    Methods: We performed intraoperative TEE on 17 patients during living-donor lobar lung transplantation (LDLLT) and investigated the usefulness of measurement of peak flow velocities through bilateral pulmonary vein (PV) anastomoses and evaluation of the equivalence.
    Results: The peak flow velocities through bilateral PV anastomoses were almost equivalent in 14 patients without complications and were not equivalent in 3 patients with complications such as vascular stenosis and peripheral atelectasis.
    Conclusions: The flow velocities through the bilateral PV anastomoses are shown to be nearly equivalent during bilateral LDLLT, and the equivalence may be one factor for predicting the success of LDLLT.

    DOI: 10.1016/j.healun.2004.05.021

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  • Therapeutic Effect of Beta-Stimulant on Patients with Brugada Syndrom(Arrhythmia, Pharmacological Therapy 2 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

    Watanabe Atsuyuki, Morita Hiroshi, Sumida Wakako, Banba Kimikazu, Nishii Nobuhiro, Nagase Satoshi, Nakamura Kazufumi, Saitoh Hironori, Kusano Kengo, Ohe Toru

    Circulation journal : official journal of the Japanese Circulation Society   69   536 - 536   2005.3

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  • The Use of Low Dose Quinidine Test to Differentiate between Symptomatic and Asymptomatic Patients with Brugada Syndrome (Arrhythmia, Diagnosis/Pathophysiology/EPS 5 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

    Watanabe Atsuyuki, Morita Hiroshi, Sumida Wakako, Banba Kimikazu, Nishii Nobuhiro, Nagase Satoshi, Nakamura Kazufumi, Saitoh Hironori, Kusano Kengo, Ohe Toru

    Circulation journal : official journal of the Japanese Circulation Society   69   290 - 290   2005.3

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  • Relationship between oxidative stress and systolic dysfunction in patients with hypertrophic cardiomyopathy

    K Nakamura, KF Kusano, H Matsubara, Y Nakamura, A Miura, N Nishii, K Banba, S Nagase, K Miyaji, H Morita, H Saito, T Emori, T Ohe

    JOURNAL OF CARDIAC FAILURE   11 ( 2 )   117 - 123   2005.3

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    Background: Progression of hypertrophic cardiomyopathy (HCM) to left ventricular dilatation and systolic dysfunction sometimes occurs. However, the mechanism is not known. We examined whether oxidative stress was elevated in myocardia of HCM patients and whether the levels were correlated with left ventricular dilatation and systolic dysfunction.
    Methods and Results: Endomyocardial biopsy samples obtained from the right ventricular side of the septum of 31 patients with HCM, and 10 control subjects were studied immunohistochemically for the expression of 4-hydroxy-2-nonenal (HNE)-modified protein, which is a major lipid peroxidation product. Expression of HNE-modified protein was found in all myocardial biopsy samples from patients with HCM. Expression was distinct in the cytosol of cardiomyocytes. The expression levels in patients with HCM were significantly increased compared with those in control subjects (P = .0005). The expression levels in patients with HCM were correlated with left ventricular end-diastolic diameter (r = 0.483, P = .0053) and end-systolic diameter (r = 0.500, P = .0037) determined by echocardiography. The expression levels were inversely con-elated with left ventricular ejection fraction determined by left ventriculography (r = -0.640, P = .0001).
    Conclusion: Oxidative stress was elevated in myocardia of HCM patients and the levels were correlated with left ventricular dilatation and systolic dysfunction. Oxidative stress is involved in the pathogenesis of heart failure in patients with HCM.

    DOI: 10.1016/j.cardfail.2004.05.005

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  • 臨床 心臓の病気・病態での突然死 QT延長症候群

    渡辺敦之, 中村一文, 森田 宏, 草野研吾, 大江 透

    日本臨床   63,7,1171-1177   2005

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  • 頻回の心室細動発作に対してキニジンが著効したBrugada症候群の1例

    渡辺敦之, 森田 宏, 草野研吾, 角田和歌子, 伴場主一, 西井伸洋, 永瀬 聡, 中村一文, 斎藤博則, 大江 透

    心臓   37,SUPPL.3,68-72   2005

  • Risk of alveolar hemorrhage in patients with primary pulmonary hypertension -anticoagulation and epoprostenol therapy-

    Ogawa A, Matsubara H, Fujio H, Miyaji K, Nakamura K, Morita H, Saito H, Kusano FK, Emori T, Date H, Ohe T

    Circulation Journal   2005

  • Hepatocyte growth factor gene therapy reduces ventricular arrhythmia in animal models of myocardial ischemia.

    Yumoto A, Kusano FK, Nakamura K, Hashimoto K, Aoki M, Morishita R, Kaneda Y, Ohe T

    Acta Med. Okayama   2005

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  • Prednisolone inhibits proliferation of cultured pulmonary artery smooth muscle cells of patients with idiopathic pulmonary arterial hypertension.

    Ogawa A, Nakamura K, Matsubara H, Fujio H, Ikeda T, Kobayashi K, Miyazaki I, Asanuma M, Miyaji K, Miura D, Kusano FK, Date H, Ohe T

    Circulation   2005

  • 65) 院内AEDによる除細動にて救命された2症例(第84回日本循環器学会中国地方会)

    斉藤 博則, 江森 哲郎, 森田 宏, 中村 一文, 大江 透, 林 峰栄, 氏家 良人

    Circulation journal : official journal of the Japanese Circulation Society   68   945 - 945   2004.10

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  • 8) マラソン中に心肺停止をきたした右冠動脈起始異常の一症例(第84回日本循環器学会中国地方会)

    伴場 主一, 宮地 晃平, 清藤 哲司, 永瀬 聡, 中村 一文, 森田 宏, 齋藤 博則, 村上 充, 江森 哲郎, 大江 透, 谷本 耕司郎

    Circulation journal : official journal of the Japanese Circulation Society   68   939 - 939   2004.10

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  • 72) 高齢にて発症したQT延長症候群の一例(第84回日本循環器学会中国地方会)

    三浦 大志, 中村 一文, 久松 研一, 永瀬 聡, 森田 宏, 竹中 志保, 斉藤 博則, 江森 哲郎, 大江 透, 西内 崇将, 幡 芳樹, 水尾 浩三

    Circulation journal : official journal of the Japanese Circulation Society   68   946 - 946   2004.10

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  • 94) 原発性肺高血圧症患者におけるMCP-1(第84回日本循環器学会中国地方会)

    橋本 克史, 中村 一文, 藤尾 栄起, 永瀬 聡, 宮地 克維, 森田 宏, 齋藤 博則, 草野 研吾, 江森 哲郎, 大江 透, 松原 広己

    Circulation journal : official journal of the Japanese Circulation Society   68   948 - 948   2004.10

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  • Characterization of the bone morphogenetic protein (BMP) system in human pulmonary arterial smooth muscle cells isolated from a sporadic case of primary pulmonary hypertension: Roles of BMP type IB receptor (activin receptor-like kinase-6) in the mitotic action

    M Takeda, F Otsuka, K Nakamura, K Inagaki, J Suzuki, D Miura, H Fujio, H Matsubara, H Date, T Ohe, H Makino

    ENDOCRINOLOGY   145 ( 9 )   4344 - 4354   2004.9

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    The functional involvement of bone morphogenetic protein (BMP) system in primary pulmonary hypertension (PPH) remains unclear. Here we demonstrate a crucial role of the BMP type 113 receptor, activin receptor-like kinase (ALK)-6 for pulmonary arterial smooth muscle cell (pphPASMC) mitosis isolated from a sporadic PPH patient bearing no mutations in BMPR2 gene. A striking increase in the levels of ALK-6 mRNA was revealed in pphPASMC compared with control PASMCs, in which ALK-6 transcripts were hardly detectable. BMP-2 and -7 stimulated the mitosis of pphPASMCs, which was opposite to their suppressive effects on the mitosis of the control PASMCs. BMP-4 and -6 and activin inhibited pphPASMC mitosis, whereas these did not affect control PASMCs. The presence of BMP signaling machinery in pphPASMCs was elucidated based on the analysis on Id-1 transcription and Smad-reporter genes. Overexpression of a dominant-negative ALK-6 construct revealed that ALK-6 plays a key role in the mitosis as well as intracellular BMP signaling of pphPASMCs. Gene silencing of ALK-6 using small interfering RNA also reduced DNA synthesis as well as Id-1 transcription in pphPASMCs regardless of BMP-2 stimulation. Although Id-1 response was not stimulated by BMP-2 in control PASMCs, the gene delivery of wild-type ALK-6 caused significant increase in the Id-1 transcripts in response to BMP-2. Additionally, inhibitors of ERK and p38 MAPK pathways suppressed pphPASMC mitosis induced by BMP-2, implying that the mitotic action is in part MAPK dependent. Thus, the BMP system is strongly involved in pphPASMC mitosis through ALK-6, which possibly leads to activation of Smad and MAPK, resulting in the progression of vascular remodeling of pulmonary arteries in PPH.

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  • Effect of a kink in unilateral pulmonary artery anastomosis on velocities of blood flow through bilateral pulmonary vein anastomose's in living-donor lobar lung transplantation

    K Miyaji, K Nakamura, T Maruo, H Morita, H Saito, T Emori, K Goto, H Date, T Ohe

    JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY   17 ( 9 )   998 - 999   2004.9

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    Intraoperative transesophageal echocardiography is generally performed to detect vascular complications during lung transplantation. We report a case with a kink in pulmonary artery (PA) anastomosis suggested by an abnormal flow profile of pulmonary vein (PV) anastomoses during living-donor lobar lung transplantation. During the transplantation, velocity of blood flow through the right PV anastomosis showed abnormal elevation. Then, the patient's PA pressure elevated abnormally and a kink in the left PA anastomosis was found. Careful monitoring of PV anastomoses; may enable detection of not only an abnormality of PV anastomoses but also that of PA anastomoses, especially in living-donor lobar lung transplantation.

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  • Differences between flow profiles of pulmonary vein anastomoses affected by peripheral atelectasis in cadaveric and bilateral living-donor lobar lung transplantations

    K Miyaji, H Matsubara, K Nakamura, T Maruo, H Morita, H Saito, KF Kusano, T Emori, K Goto, H Date, T Ohe

    JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY   17 ( 9 )   1003 - 1004   2004.9

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    We report two cases of peripheral atelectasis during cadaveric and living-donor lobar lung transplantation, which had different effects on the flow profile of pulmonary vein (PV) anastomoses. In the patient who underwent living-donor lobar lung transplantation, we detected the increase in the velocity of blood flow through the left PV anastomosis by intraoperative transesophageal echocardiography. Then peripheral atelectasis occurred in the transplanted left lung lobe. On the other hand, in the patient who underwent cadaveric bilateral lung transplantation, peripheral atelectasis occurred, but no changes in velocities of blood flow through PV anastomoses were detected by intraoperative transesophageal echocardiography. This difference may have been caused by the difference in sizes of pulmonary beds of transplanted grafts. These findings indicate the necessity of careful monitoring of PV anastomoses, especially in cases of living-donor lobar lung transplantation.

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  • Diagnostic value of epinephrine test for genotyping LQT1, LQT2, and LQT3 forms of congenital long QT syndrome

    W Shimizu, T Noda, H Takaki, N Nagaya, K Satomi, T Kurita, K Suyama, N Aihara, K Sunagawa, S Echigo, Y Miyamoto, Y Yoshimasa, K Nakamura, T Ohe, JA Towbin, SG Priori, S Kamakura

    HEART RHYTHM   1 ( 3 )   276 - 283   2004.9

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    OBJECTIVES The aim of this study was to test the hypothesis that epinephrine test may have diagnostic value for genotyping LQT1, LQT2, and LQT3 forms of congenital long QT syndrome (LQTS).
    BACKGROUND A differential response of dynamic QT interval to epinephrine infusion between LQT1, LQT2, and LQT3 syndromes has been reported, indicating the potential diagnostic value of the epinephrine test for genotyping the three forms.
    METHODS The responses of 12-lead ECG parameters to epinephrine were retrospectively examined in 15 LQT1, 10 LQT2, 8 LQT3, and 10 healthy volunteers to select the best ECG criteria for separating the four groups. The epinephrine test then was prospectively conducted in 42 probands clinically affected with LQTS, their 67 family members, and 10 new volunteers. The best criteria were applied in a blinded fashion to prospectively separate a different group of 31 LQT1, 23 LQT2, 6 LQT3, and 30 Control patients (10 genotype-negative LQT1, 10 genotype-negative LQT2 family members, and 10 volunteers).
    RESULTS The sensitivity (penetrance) by ECG diagnostic criteria was lower in LQT1 (68%) than in LQT2 (83%) or LQT3 (83%) before epinephrine and was improved with steady-state epinephrine in LQT1 (87%) and LQT2 (91%) but not in LQT3 (83%), without the expense of specificity (100%). The sensitivity and specificity to differentiate LQT1 from LQT2 were 97% and 96%, those from LQT3 were 97% and 100%, and those from Control were 97% and 100%, respectively, when Delta mean corrected Q-Tend greater than or equal to35ms at steady state was used. The sensitivity and specificity to differentiate LQT2 from LQT3 or Control were 100% and 100%, respectively, when Delta mean corrected Q-Tend greater than or equal to80ms at peak was used.
    CONCLUSIONS Epinephrine infusion is a powerful test to predict the genotype of LQT1, LQT2, and LQT3 syndromes as well as to improve the clinical diagnosis of genotype-positive patients, especially those with LQT1 syndrome.

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  • Mutation site-specific differences in arrhythmic risk and sensitivity to sympathetic stimulation in the LQT1 form of congenital long QT syndrome - Multicenter study in Japan

    W Shimizu, M Horie, S Ohno, K Takenaka, M Yamaguchi, M Shimizu, T Washizuka, Y Aizawa, K Nakamura, T Ohe, T Aiba, Y Miyamoto, Y Yoshimasa, JA Towbin, SG Priori, S Kamakura

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   44 ( 1 )   117 - 125   2004.7

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    OBJECTIVES We sought to compare the arrhythmic risk and sensitivity to sympathetic stimulation of mutations located in transmembrane regions and C-terminal regions of the KCNQ1 channel in the LQT1 form of congenital long QT syndrome (LQTS).
    BACKGROUND The LQT1 syndrome is frequently manifested with variable expressivity and incomplete penetrance and is much more sensitive to sympathetic stimulation than the other forms.
    METHODS Sixty-six LQT1 patients (27 families) with a total of 19 transmembrane mutations and 29 patients (10 families) with 8 C-terminal mutations were enrolled from five Japanese institutes.
    RESULTS Patients with transmembrane mutations were more frequently affected based on electrocardiographic (ECG) diagnostic criteria (82% vs. 24%, p &lt; 0.0001) and had more frequent LQTS-related cardiac events (all cardiac events: 55% vs. 21%, p = 0.002; syncope: 55% vs. 21%, p = 0.002; aborted cardiac arrest or unexpected sudden cardiac death: 15% vs. 0%, p = 0.03) than those with C-terminal mutations. Patients with transmembrane mutations had a greater risk of first cardiac events occurring at an earlier age, with a hazard ratio of 3.4 (p = 0.006) and with an 8% increase in risk per 10-ms increase in corrected Q-Tend. The baseline ECG parameters, including Q-Tend, Q-Tpeak, and Tpeak-end intervals, were significantly greater in patients with transmembrane mutations than in those with C-terminal mutations (p &lt; 0.005). Moreover, the corrected Q-Tend and Tpeak-end were more prominently increased with exercise in patients with transmembrane mutations (p &lt; 0.005).
    CONCLUSIONS In this multicenter Japanese population, LQT1 patients with transmembrane mutations are at higher risk of congenital LQTS-related cardiac events and have greater sensitivity to sympathetic stimulation, as compared with patients with C-terminal mutations. (C) 2004 by the American College of Cardiology Foundation.

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  • Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia

    K Ueda, K Nakamura, T Hayashi, N Inagaki, M Takahashi, T Arimura, H Morita, Y Higashiuesato, Y Hirano, M Yasunami, S Takishita, A Yamashina, T Ohe, M Sunamori, M Hiraoka, A Kimura

    JOURNAL OF BIOLOGICAL CHEMISTRY   279 ( 26 )   27194 - 27198   2004.6

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    Hyperpolarization-activated cyclic nucleotide-gated channel 4 gene HCN4 is a pacemaker channel that plays a key role in automaticity of sinus node in the heart, and an HCN4 mutation was reported in a patient with sinus node dysfunction. Expression of HCN4 in the heart is, however, not confined to the sinus node cells but is found in other tissues, including cells of the conduction system. On the other hand, mutations in another cardiac ion channel gene, SCN5A, also cause sinus node dysfunction as well as other cardiac arrhythmias, including long QT syndrome, Brugada syndrome, idiopathic ventricular fibrillation, and progressive cardiac conduction disturbance. These observations imply that HCN4 abnormalities may be involved in the pathogenesis of various arrhythmias, similar to the SCN5A mutations. In this study, we analyzed patients suffering from sinus node dysfunction, progressive cardiac conduction disease, and idiopathic ventricular fibrillation for mutations in HCN4. A missense mutation, D553N, was found in a patient with sinus node dysfunction who showed recurrent syncope, QT prolongation in electrocardiogram, and polymorphic ventricular tachycardia, torsade de pointes. In vitro functional study of the D553N mutation showed a reduced membranous expression associated with decreased If currents because of a trafficking defect of the HCN4 channel in a dominant-negative manner. These data suggest that the loss of function of HCN4 is associated with sinus nodal dysfunction and that a consequence of pacemaker channel abnormality might underlie clinical features of QT prolongation and polymorphic ventricular tachycardia developed under certain conditions.

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  • Sarcomere-length dependence of lattice volume and radial mass transfer of myosin cross-bridges in rat papillary muscle

    N Yagi, H Okuyama, H Toyota, J Araki, J Shimizu, G Iribe, K Nakamura, S Mohri, K Tsujioka, H Suga, F Kajiya

    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY   448 ( 2 )   153 - 160   2004.5

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    We examined the sarcomere length-dependence of the spacing of the hexagonal lattice of the myofilaments and the mass transfer of myosin cross-bridges during contraction of right ventricular papillary muscle of the rat. The lattice spacing and mass transfer were measured by using X-ray diffraction, and the sarcomere length was monitored by laser diffraction at the same time. Although the lattice spacing and the sarcomere length were inversely related, their relationship was not exactly isovolumic. The cell volume decreased by about 15% when the sarcomere length was shortened from 2.3 mum to 1.8 mum. Twitch tension increased with sarcomere length (the Frank-Starling law). At the peak tension, the ratio of the intensity of the (1,0) equatorial reflection to that of the (1,1) reflection was smaller when the tension was greater, showing that the larger tension at a longer sarcomere length accompanies a larger amount of mass transfer of cross-bridges from the thick to the thin filament. The result suggests that the Frank-Starling law is due to an increase in the number of myosin heads attached to actin, not in the average force produced by each head.

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  • 129) 冠動脈炎による急性心筋梗塞を発症した若年女性の一症例(第83回日本循環器学会中国・四国合同地方会)

    伴場 圭一, 木村 英夫, 永瀬 聡, 中村 一文, 森田 宏, 齋藤 博則, 江森 哲郎, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   68   837 - 837   2004.4

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  • 130) 心室細動にて発症し救命しえた冠動脈瘤病変を有した一症例(第83回日本循環器学会中国・四国合同地方会)

    伴場 主一, 木村 英夫, 永瀬 聡, 中村 一文, 森田 宏, 齋藤 博則, 江森 哲郎, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   68   837 - 837   2004.4

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  • 121) プロスプロスタグランディンI2による薬剤性間質性肺炎を来した原発性肺高血圧症の一例(第83回日本循環器学会中国・四国合同地方会)

    木村 英夫, 宮地 晃平, 河野 康之, 伴場 圭一, 藤尾 栄起, 宮地 克維, 中村 一文, 森田 宏, 齋藤 博則, 江森 哲郎, 大江 透, 松原 広己

    Circulation journal : official journal of the Japanese Circulation Society   68   836 - 836   2004.4

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  • OE-297 Elevated Levels of 8-Hydroxy-2-Deoxyguanosine in Serum and Myocardium of Patients with Dilated Cardiomyopathy(Cardiomyopathy, Clinical 6 (M) : OE37)(Oral Presentation (English))

    Nakamura Kazufumi, Kusano Kengo, Miura Aya, Nishii Nobuhiro, Miyaji Katsumasa, Nagase Satoshi, Morita Hiroshi, Saitoh Hironori, Emori Tetsuro, Nakamura Yoichi, Murakami Takashi, Matsubara Hiromi

    Circulation journal : official journal of the Japanese Circulation Society   68   212 - 213   2004.3

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  • PJ-016 Effect of Sodium Channel Blocker on Electrophysiologic : Characteristics in Patients with the Brugada Syndrome(Arrhythmia, Diagnosis/Pathophysiology/EPS 5 (A) : PJ3)(Poster Session (Japanese))

    Nagase Satoshi, Morita Hiroshi, Nishii Nobuhiro, Banba Kimikazu, Nakamura Kazufumi, Saitoh Hironori, Kusano Kengo, Emori Tetsuro, Ohe Toru

    Circulation journal : official journal of the Japanese Circulation Society   68   483 - 483   2004.3

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  • PJ-007 Longitudinal and Transverse Activation Pattern in Human Coronary Sinus(Arrhythmia, Diagnosis/Pathophysiology/EPS 4 (A): PJ2)(Poster Session (Japanese))

    Nagase Satoshi, Nishii Nobuhiro, Banba Kimikazu, Nakamura Kazufumi, Morita Hiroshi, Saitoh Hironori, Kusano Kengo, Emori Tetsuro, Ohe Toru

    Circulation journal : official journal of the Japanese Circulation Society   68   481 - 481   2004.3

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  • PE-030 Reproducibility of Induction of Ventricular Fibrillation by Programmed Electrical Stimulation in Patients with Brugada Syndrome(Arrhythmia, Diagnosis/Pathophysiology/EPS 6 (A) : PE5)(Poster Session (English))

    Watanabe Atsuyuki, Morita Hiroshi, Nagase Satoshi, Nakamura Kazufumi, Saitoh Hironori, Kusano Kengo, Emori Tetsuro, Ohe Toru

    Circulation journal : official journal of the Japanese Circulation Society   68   369 - 369   2004.3

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  • OE-340 Body Surface Activation during Polymorphic Ventricular Tachycardia and Ventricular Fibrillation in Patients with Brugada Syndrome(Arrhythmia, Diagnosis/Pathophysiology/EPS 11 (A) : OE43)(Oral Presentation (English))

    Morita Hiroshi, Kusano Kengo, Nagase Satoshi, Nakamura Kazufumi, Saito Hironori, Emori Tetsuro, Ohe Tohru

    Circulation journal : official journal of the Japanese Circulation Society   68   222 - 223   2004.3

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  • β遮断薬による心不全・不整脈治療の基礎と臨床 カルベジロールを中心として β遮断薬と酸化ストレス

    中村 一文, 垣下 幹夫, 草野 研吾, 三浦 綾, 久松 研一, 永瀬 聡, 森田 宏, 斉藤 博則, 江森 哲郎, 浅沼 幹人, 小川 紀雄, 宮崎 正博, 中村 陽一, 松原 広己, 伏見 和郎, 豊國 伸哉, 大江 透

    心電図   24 ( 1 )   15 - 21   2004.1

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    拡張型心筋症患者と正常心機能者の心内膜生検組織において,過酸化脂質の代謝産物である4-Hydroxy-2-nonenal(HNE)修飾蛋白質を免疫染色にて検出した.拡張型心筋症患者全例の心筋においてHNE修飾蛋白質が増加していた.その増加は心筋の細胞質に多かった.更にカルベジロール投与を行った後再び調べたところ,心機能の改善と共に,HNE修飾蛋白質が有意に低下していた.以上の検討より,活性酸素による酸化ストレスの発生が不全心筋において増強しており,カルベジロールによるその抑制が心不全治療のターゲットの1つになりうることが示唆された

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  • Sinus node function in patients with brugada-type ECG.

    Morita H, Kusano FK, Nagase S, Miyaji K, Hiramatsu S, Banba K, Nishii N, Watanabe A, Kakishita M, Morita TS, Nakamura K, Saito H, Emori T, Ohe T

    Circulation Journal   2004

  • PGI2持続静注療法中の抗凝固療法について

    小川愛子, 松原広己, 藤尾栄起, 宮地克維, 渡辺敦之, 永瀬 聡, 中村一文, 森田 宏, 斎藤博則, 江森哲郎, 伊達洋至, 清水信義, 大江 透

    Progress in Medicine   24,1,310-313   2004

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  • β遮断薬による心不全・不整脈治療の基礎と臨床ーカルベジロールを中心としてー3.β遮断薬と酸化ストレス

    中村一文, 垣下幹夫, 草野研吾, 三浦 綾, 久松研一, 永瀬 聡, 森田 宏, 斎藤博則, 江森哲郎, 浅沼幹人, 小川紀雄, 宮崎正博, 中村陽一, 松原広己, 伏見和郎, 豊國伸哉, 大江 透

    Japanese Journal of Electrocardiology   24,1,15-21   2004

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  • 高齢にて発症したQT延長症候群の1例 -同一家系内で異なる発症様式を示したLQT1の1家系ー

    三浦大志, 中村一文, 久松研一, 森田 宏, 森田志保, 永瀬 聡, 斎藤博則, 草野研吾, 江森哲郎, 大江 透, 大内田 守, 清水憲二, 西内崇将, 幡 芳樹, 水尾浩三, 大杉 保

    Therapeutic Research   25,11,2137-2141   2004

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  • 心不全における酸化ストレスの関与-基礎的ならびに臨床的検討

    中村一文, 草野研吾, 垣下幹夫, 三浦 綾, 久松研一, 西井伸洋, 伴場主一, 渡辺敦之, 藤尾栄起, 宮地克維, 永瀬 聡, 森田 宏, 斎藤博則, 江森哲郎, 浅沼幹人, 宮崎正博, 中村陽一, 松原広己, 大江 透

    岡山医学会雑誌   116,9-16   2004

  • Failure of disopyramide to improve right ventricular outflow tract obstruction after living-donor lobar transplantation.

    Miyaji K, Matsubara H, Kajiya M, Tani Y, Nakamura K, Morita H, Emori T, Date H, Ohe T

    Circulation Journal   2004

  • PGI2持続静注療法を施行した肺高血圧症35例の検討

    小川愛子, 松原広己, 藤尾栄起, 宮地克維, 永瀬 聡, 中村一文, 森田 宏, 斎藤博則, 江森哲郎, 伊達洋至, 清水信義, 大江 透

    Therapeutic Research   25,10,29-30   2004

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  • 著明なT wave alternans現象を示したLQT1の一家系

    森田 宏, 中村一文, 大田恵子, 森田志保, 三浦大志, 斎藤博則, 草野研吾, 江森哲郎, 大江 透, 幡 芳樹, 水尾浩三

    心臓   36,3,136-141   2004

  • 特集 不整脈死を防ぐ 不整脈死の基質を識る 心不全

    中村一文

    Heart View   8,1,45-49   2004

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  • 特発性心室細動と考えられた2症例 -Short coupled variant of torsades de pointesとの比較検討-

    渡辺敦之, 森田 宏, 伴場主一, 西井伸洋, 永瀬 聡, 中村一文, 斎藤博則, 草野研吾, 江森哲郎, 大江 透

    Japanese Journal of Electrocardiology   24,4,S4-61-S4-67   2004

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  • Evaluation of the usefulness of recording the ECG in the 3rd intercostal space and prevalence of brugada-type ECG in accordance with recently established electrocardiographic criteria.

    Hisamatsu K, Morita H, Kusano FK, Takenaka S, Nagase S, Nakamura K, Emori T, Ohe T

    Circulation Journal   2004

  • Effects of cyclooxygenase inhibition on endothelial function in hypertensive patients treated with angiotensin-converting enzyme inhibitors.

    Yamanari H, Nakamura K, Kakishita M, Ohe T

    Clin. Cardiol   2004

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  • Usefulness of body surface mapping to differentiate patients with brugada syndrome from patients with asymptomatic brugada syndrome.

    Hisamatsu K, Kusano FK, Morita H, Takenaka S, Nagase S, Nakamura K, Emori T, Matsubara H, Ohe T

    Acta Med. Okayama   2004

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  • Epoprostenol therapy decreases elevated circulating levels of monocyte chemoattractant protein-1 in patients with primary pulmonary hypertension.

    Hashimoto K, Nakamura K, Fujio H, Miyaji K, Morita H, Kusano K, Date H, Shimizu N, Emori T, Matsubara H, Ohe T

    Circulation Journal   2004

  • X-ray diffraction from a left ventricular wall of rat heart.

    Yagi N, Shimizu J, Mohri S, Araki J, Nakamura K, Okuyama H, Toyota H, Morimoto T, Morizane Y, Kurusu M, Miura T, Hashimoto K, Tsujioka K, Suga H, Kajiya F

    Biopysical Journal   2004

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  • 著明なT wave alteransを認めた先天性QT延長症候群の3症例(第82回日本循環器学会中国地方会)

    渡辺 敦之, 森田 宏, 竹内 一文, 大田 恵子, 西井 伸洋, 池田 哲也, 永瀬 聡, 中村 一文, 松原 広己, 江森 哲郎, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   67   998 - 998   2003.10

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  • 194)心室性不整脈を合併した心線維腫の一例

    西井 伸洋, 藤尾 栄起, 小林 誠, 永瀬 聡, 垣下 幹夫, 中村 一文, 森田 宏, 江森 哲朗, 松原 広己, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   67   866 - 866   2003.4

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  • 77)冠静脈洞内で通電することによってアフレーションが成功したWPW症候群の一症例

    伴場 主一, 大河 啓介, 永瀬 聡, 垣下 幹夫, 中村 一文, 森田 宏, 江森 哲郎, 松原 広己, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   67   853 - 853   2003.4

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  • 92)完全型心内膜床欠損症の一成人例

    渡邊 敦之, 河合 勇介, 宮地 克雄, 大塚 ふよう, 中村 一文, 森田 宏, 江森 哲郎, 松原 広己, 大江 透, 佐野 俊二

    Circulation journal : official journal of the Japanese Circulation Society   67   855 - 855   2003.4

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  • 87)Short-Coupled Variant of Torsades de Pointesの二例

    三浦 龍志, 永瀬 聡, 中村 一文, 森田 宏, 江森 哲郎, 松原 広己, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   67   854 - 854   2003.4

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  • 73)Brugada症候群における上室性不整脈の合併

    森田 宏, 永瀬 聡, 中村 一文, 江森 哲朗, 松原 広己, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   67   853 - 853   2003.4

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  • Localization of Depolarization Abnormality in Patient with Brugada : Using Body Surface Signal Averaged ECG

    Hisamatsu Kenichi, Kusano Kengo, Morita Hiroshi, Takenaka Shiho, Nagase Satoshi, Nakamura Kazufumi, Emori Tetsuro, Matsubara Hiromi, Ohe Toru

    Circulation journal : official journal of the Japanese Circulation Society   67   530 - 530   2003.3

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  • Long-Term Clinical Course of Non-lschemic Cardiomyopathy Patients with Ventricular Tachycardia

    Nishii Nobuhiro, Emori Tetsuro, Nagase Satoshi, Morita Hiroshi, Nakamura Kazufumi, Matsubara Hiromi, Ohe Toru

    Circulation journal : official journal of the Japanese Circulation Society   67   518 - 518   2003.3

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  • Left Ventricular Conduction Abnormality in Brugada Syndrome

    Nagase Satoshi, Morita Hiroshi, Nishii Nobuhiro, Kobayashi Makoto, Nakamura Kazufumi, Kakishita Mikio, Emori Tetsuro, Matsubara Hiromi, Ohe Tohru

    Circulation journal : official journal of the Japanese Circulation Society   67   577 - 577   2003.3

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  • Risk Stratification and Therapeutic Management of Patients with Right Bundle Branch Block and ST-Segment Elevation

    Emori Tetsuro, Morita Hiroshi, Takenaka-Morita Shiho, Nagase Satoshi, Nakamura Kazufumi, Kusano Kengo, Matsubara Hiromi, Ohe Tohru

    Circulation journal : official journal of the Japanese Circulation Society   67   71 - 71   2003.3

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  • Clinical Characteristics of Asymptomatic Patients with the Brugada Syndrome

    Morita Hiroshi, Morita Shiho, Ohta Keiko, Nagase Satoshi, Nakamura Kazufumi, Kusano Kengo, Emori Tetsuro, Matsubara Hiromi, Ohe Tohru

    Circulation journal : official journal of the Japanese Circulation Society   67   311 - 311   2003.3

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  • Brugada症候群の診断とリスク評価.

    森田 宏, 永瀬 聡, 西井伸洋, 伴場主一, 渡辺敦之, 谷 義則, 中村一文, 森田志保, 草野研吾, 江森哲郎, 松原広己, 大江 透

    Japanese Journal of Electrocardiology   2003

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  • PGI2持続静注療法を施行した肺高血圧症27症例の検討.

    小川愛子, 藤尾栄起, 宮地克維, 永瀬 聡, 大田恵子, 中村一文, 森田 宏, 斎藤博則, 江森哲郎, 大江 透, 松原広己, 伊達洋至, 清水信義

    Therapeutic Research   24,9,51-53   2003

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  • Pulmonary Capillary Hemangiomatosisの2症例.

    西井伸洋, 松原広己, 小川愛子, 大田恵子, 藤尾栄起, 宮地克維, 中村一文, 森田 宏, 江森哲郎, 大江 透, 青江 基, 伊達洋至

    Therapeutic Research   24,9,39-40   2003

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  • 右室自由壁脂肪浸潤を認め、不整脈源性右室異形成との鑑別を要したカテコラミン誘発性多形成心室頻拍の1例.

    森田 宏, 原岡佳代, 大田恵子, 中村陽一, 森田志保, 中村一文, 江森哲郎, 松原広己, 中谷陽子, 林 一彦, 赤木忠厚, 大江 透

    心臓   35,3,45-49   2003

  • LQT/Brugada症候群での遺伝子解析の意義.

    中村一文, 三浦大志, 森田 宏, 大江 透

    Cardiac Practice   14,4,27-33   2003

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  • Site-specific arrhythmogenesis in patients with brugada syndrome.

    Morita H, Kusano FK, Nagase S, Morita TS, Nishii N, Kakishita M, Nakamura K, Emori T, Matsubara H, Ohe T

    Journal of Cardiovasuclar Electrophysiology   2003

  • Risk stratification for asymptomatic patients with brugada syndrome --prediction of induction of ventricular fibrillation by noninvasive methods--

    Morita H, Morita TS, Kusano FK, Kobayashi M, Nagase S, Kakishita M, Nakamura K, Emori T, Matsubara H, Ohe T

    Circulation Journal   2003

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  • Epinephrine unmasks latent mutation carriers with LQT1 form congenital long-QT syndrome.

    Shimizu W, Noda T, Takaki H, Kurita T, Nagaya N, Satomi K, Suyama K, Aihara N, Kamakura S, Sunagawa K, Echigo S, Nakamura K, Ohe T

    JACC   2003

  • Local Drug DeliveryとしてのTissue Factor Pathway Inhibitorの可能性.

    中村陽一, 中村一文, 大田恵子, 草野研吾, 松原広己, 羽室 強, 植田初江, 由谷親夫, 加藤久雄, 大江 透

    Japanese Journal of Interventional Cardiology   2003

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  • Brugada症候群の不整脈の予知.

    森田 宏, 永瀬 聡, 原岡佳代, 藤尾栄起, 久松研一, 森田志保, 垣下幹夫, 中村一文, 草野研吾, 江森哲郎, 松原広己, 大江 透

    心電図   23,159-167   2003

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  • Direct evidence for increased hydroxy1 radicals in angiotensin Ⅱ-induced cardiac hypertrophy through angiotensin Ⅱ type 1a receptor.

    Kakishita M, Nakamura K, Asanuma M, Morita H, Saito H, Kusano K, Nakamura Y, Emori T, Matsubara H, Sugaya T, Ogawa N, Ohe T

    Journal of Cardiovascular Pharmacology   2003

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  • Ventricular arrhythmia induced by sodium channel blocker in patients with brugada syndrome.

    Morita H, Morita TS, Nagase S, Banba K, Nishii N, Tani Y, Watanabe A, Nakamura K, Kusano FK, Emori T, Matsubara H, Hina K, Kita T, Ohe T

    JACC   2003

  • Tissue factor expression in atrial endothelia associated with nonvalvular atrial fibrillation: possible involvement in intracardiac thrombogenesis

    Y Nakamura, K Nakamura, K Fukushima-Kusano, K Ohta, H Matsubara, T Hamuro, C Yutani, T Ohe

    THROMBOSIS RESEARCH   111 ( 3 )   137 - 142   2003

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    Introduction: Tissue factor plays a key role in the extrinsic coagulation pathway and is induced by inflammatory cytokines. Atrial myocarditis has been detected recently in some patients with lone atrial fibrillation. Virchow's triad of low blood flow, hypercoagulability, and endothelial dysfunction, enhances thrombus formation. The present study was designed to elucidate the role of endothelial dysfunction in thrombogenesis associated with nonvalvular atrial fibrillation. Material and methods: We investigated tissue factor expression in the endothelia of left atrial appendages obtained from seven patients with nonvalvular atrial fibrillation and cardiogenic thromboembolism. Tissues were divided into 7-13 sections and compared with control specimens from four patients who died of noncardiac events. Expression of tissue factor, von Willebrand factor and tissue factor pathway inhibitor was evaluated by immunohistochemistry. Results: Histopathologically, inflammatory cells infiltrated the endocardium and all seven patients showed features of persistent myocarditis. Activated T cells [15.3 +/- 9.4 cells/high power field (HPF, mean +/- S.D.) vs. control 2.2 +/- 4.4/HPF (P = 0.0294)] and a few macrophages [5.1 +/- 8.4 cells/HPF vs. control 2.4 +/- 3.5 cells/HPF (P = NS)] infiltrated the endocardium. Tissue factor was overexpressed in the endothelia particularly in tissues containing inflammatory cells and denuded matrix of the endocardium, compared with the control group. Von Willebrand factor, but not tissue factor pathway inhibitor, was also overexpressed in these tissues. Conclusion: Tissue factor expression induced by local inflammation is involved in the pathogenesis of thrombosis in patients with nonvalvular atrial fibrillation. (C) 2003 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/S0049-3848(03)00405-5

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  • Gene-specific response of dynamic ventricular repolarization to sympathetic stimulation in LQT1, LQT2 and LQT3 forms of congenital long QT syndrome

    T Noda, H Takaki, T Kurita, K Suyama, N Nagaya, A Taguchi, N Aihara, S Kamakura, K Sunagawa, K Nakamura, T Ohe, M Horie, C Napolitano, JA Towbin, SG Priori, W Shimizu

    EUROPEAN HEART JOURNAL   23 ( 12 )   975 - 983   2002.6

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    Aims Differences in the sensitivity of the genotype of the congenital long QT syndrome to sympathetic stimulation have been suggested. This study compared the influence of sympathetic stimulation on continuous corrected QT (QTc) intervals between LQT1, LQT2 and LQT3 forms of the congenital long QT syndrome.
    Methods and Results We recorded a 12-lead electrocardiogram continuously before and after bolus injection (0.1 mug. kg(-1)) of epinephrine followed by continuous infusion (0.1 mug. kg(-1) min(-1)) in 12 LQT1, 10 LQT2, 6 LQT3, and 13 control patients. The QT intervals and previous RR intervals of all beats were measured semi-automatically, and the QTc intervals of all beats were calculated by Bazett's method. The dynamic response of the RR interval to epinephrine was no different between the four groups. The QTc was prolonged remarkably (477 +/- 42 to 631 +/- 59 ms; P&lt;0.0005, % delta prolongation = + 32%) as the RR was maximally decreased (at peak of epinephrine), and remained prolonged at steady state conditions of epinephrine (556 +/- 56 ms; P&lt;0.0005 vs baseline, + 17%) in LQT1 patients. Epinephrine also prolonged the QTc dramatically (502 +/- 23 to 620 +/- 39 ms, P&lt;0.0005, +24%) at peak of epinephrine in LQT2 patients, but this shortened to baseline levels at steady state (531 25 ms; P=ns vs baseline, +6%). The QTc was Much less prolonged at peak of epinephrine in LQT3 (478 +/- 44 to 532 +/- 41 ms; P&lt;0.05, +11%) and controls (394 +/- 21 to 456 +/- 18 ms; P&lt;0.0005, + 16%) than in LQT1 and LQT2 patients, and shortened to the baseline levels (LQT3; 466 +/- 49 ms, -3%, controls; 397 +/- 16 ms, +1%; P=ns vs baseline) at steady state.
    Conclusion Our data suggest that the dynamic response of ventricular repolarization to sympathetic stimulation differs between LQT1, LQT2 and LQT3 syndromes, and may explain why the trigger of cardiac events differs between the genotypes.
    (C) 2002 The European Society of Cardiology. Published by Elsevier Science Ltd. All rights reserved.

    DOI: 10.1053/euhj.2001.3079

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  • 128)高熱と心膜炎で発症した成人発症型スティル病の一例(日本循環器学会 第79回中国四国地方会)

    三浦 龍志, 佐藤 克政, 中村 一文, 森田 宏, 江森 哲郎, 松原 広己, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   66   975 - 975   2002.4

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  • 4)若年者の冠動脈病変の原因として弾性線維性仮性黄色腫(PXE)が考えられた1例(日本循環器学会 第79回中国四国地方会)

    垣下 幹夫, 中村 一文, 森田 宏, 江森 哲郎, 松原 広己, 大江 透

    Circulation journal : official journal of the Japanese Circulation Society   66   961 - 961   2002.4

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  • Persistent Adenovirus Myocarditis : Is It Degeneration or Inflammation?

    Ohta Keiko, Nakamura Kazufumi, Kusano Kengo, Nagase Satoshi, Kakishita Mikio, Morita Hiroshi, Emori Tetsuro, Matsubara Hiromi, Ohe Toru, Nakamura Yoichi

    Circulation journal : official journal of the Japanese Circulation Society   66   840 - 840   2002.3

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  • Characteristics of action potential duration (APD) restitution in Angiotensin II type 1a receptor knockout (AT1a KO) mice

    Kakishita Mikio, Hashimoto Katsushi, Nakamura Kazufumi, Morita Hiroshi, Kusano Kengo, Emori Tetsurou, Matsubara Hiromi, Ohe Tohru

    Circulation journal : official journal of the Japanese Circulation Society   66   688 - 688   2002.3

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  • Usefullness of 16-lead signal average electrocardiogram to differentiate between Brugada syndrome and asymptomatic Brugada

    Hisamatsu Kenichi, Kusano Kengo, Morita Hiroshi, Takenaka Shiho, Nagase Satoshi, Nakamura Kazufumi, Emori Tetsuro, Matsubara Hiromi, Ohe Toru

    Circulation journal : official journal of the Japanese Circulation Society   66   684 - 684   2002.3

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  • The Ventricular Activation Pattern of the Body Surface Mapping during Polymorphic Ventricular Tachycardia in Patients with the Brugada Syndrome

    Morita Hiroshi, Nagase Satoshi, Hisamatsu Kenichi, Kobayashi Makoto, Nakamura Kazufumi, Kusano Kengo, Emori Tetsuro, Matsubara Hiromi, Ohe Tohru

    Circulation journal : official journal of the Japanese Circulation Society   66   452 - 452   2002.3

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  • Atrial fibrillation and atrial vulnerability in patients with brugada syndrome.

    Morita H, Fukushima KK, Nagase S, Fujimoto Y, Hisamatsu K, Fujio H, Haraoka K, Kobayashi M, Takenaka MS, Nakamura K, Emori T, Matsubara H, Hina K, Kita T, Fukatani M, Ohe T

    JACC   2002

  • Anti-inflammatory effects of long-lasting locally-delivered human recombinant tissue factor pathway inhibitor after balloon angioplasty.

    Nakamura Y, Nakamura K, Ohta K, Matsubara H, Yutani C, Hamuro T, Kato H, Ohe T

    Basic Res Cardiol   2002

  • Altered nano/micro-order mechanical property of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension.

    Nakamura K, Hashimoto K, Ohta K, Kakishita M, Fujio H, Motita H, Fukushima KK, Emori T, Matsubara H, Ohe T, Date H, Shimizu N, Kataoka N, Mochizuki S, Hashimoto K, Shimizu J, Kajiya F

    Curculation   2002

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  • 原発性肺高血圧症における右室心筋内微小血管の組織学的検討

    大田恵子, 中村陽一, 草野研吾, 永瀬 聡, 宮地克維, 中村一文, 森田 宏, 江森哲郎, 松原広己, 大江 透

    Therapeutic Research   23,2,34-37   2002

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  • 心不全を合併した致死性不整脈の治療

    中村一文, 永瀬 聡, 大江 透

    循環器科   52,4,309-315   2002

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  • Differential effects of beta-blockade on dispersion of repolarization in the absence and presence of sympathetic stimulation between the LQT1 and LQT2 forms of congenital long QT syndrome.

    Shimizu W, Tanabe Y, Aiba T, Inagaki M, Kurita T, Suyama K, Nagaya N, Taguchi A, Aihara N, Sunagawa K, Nakamura K, Ohe T, Towbin JA, Priori SG, Kamakura S

    JACC   2002

  • Carvedilol decreases elevated oxidative stress in human failing myocardium.

    Nakamura K, Kusano K, Nakamura Y, Kakishita M, Ohta K, Nagase S, Yamamoto M, Miyaji K, Saito H, Morita H, Emori T, Matsubara H, Toyokuni S, Ohe T

    Circulation   2002

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  • Epicardial electrogram of the right ventricular outflow tract in patients with the brugada syndrome.

    Nagase S, Fukushima KK, Morita H, Fujimoto Y, Kakishita M, Nakamura K, Emori T, Matsubara H, Ohe T

    JACC   2002

  • The ventricular arrhythmia induced by Pilsicainide in patients with the Brugada syndrome

    OGAWA A, Morita Hiroshi, Nagase Satoshi, Hisamatsu Kenichi, Yamamoto Mika, Ootsuka Fuyo, Morita Shiho, Kakishita Mikio, Nakamura Kazufumi, Kusano Kengo, Emori Tetsuro, Matsubara Hiromi, Ohe Tohru

    Circulation J   66   298 - 298   2002

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  • 57) 末端肥大症に合併した僧帽弁閉鎖不全症の2症例(日本循環器学会 第78回中国地方会)

    岩崎 淳, 森田 宏, 宮地 克雄, 原岡 佳代, 中村 一文, 草野 研吾, 江森 哲郎, 松原 広己, 大江 透

    Japanese circulation journal   65   802 - 802   2001.10

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  • 80) 心電図上, 著明なQT延長並びにT波の交代現象を示した原発性副甲状腺機能低下症の1例(日本循環器学会 第78回中国地方会)

    藤尾 栄起, 草野 研吾, 岩崎 淳, 原岡 佳代, 谷 義則, 小林 誠, 池田 哲也, 永瀬 聡, 宮地 克雄, 山本 美香, 橋本 克史, 中村 一文, 垣下 幹夫, 斎藤 博則, 森田 宏, 松原 広巳, 江森 哲郎, 大江 透, 徳永 常登

    Japanese circulation journal   65   805 - 805   2001.10

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  • 43) Brugada症候群における心房受攻性異常(日本循環器学会 第78回中国地方会)

    森田 宏, 草野 研吾, 永瀬 聡, 中村 一文, 久松 研一, 小林 誠, 山本 美香, 竹中 志保, 江森 哲郎, 松原 広己, 大江 透

    Japanese circulation journal   65   801 - 801   2001.10

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  • 55) 1年間でデルタ波の出現と自然消退によりA型WPW症候群からC型WPW症候群への心電図変化を示した肥大型心筋症の一例(日本循環器学会 第78回中国地方会)

    小林 誠, 森田 宏, 谷 義則, 原岡 佳代, 岩崎 淳, 藤尾 栄紀, 池田 哲也, 片山 祐介, 永瀬 聡, 宮地 克雄, 山本 美香, 垣下 幹夫, 中村 一文, 斉藤 博則, 草野 研吾, 江森 哲郎, 松原 広己, 大江 透, 中濱 一

    Japanese circulation journal   65   802 - 802   2001.10

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  • 115) 器質的異常を伴いBrugada型心電図を呈した一症例

    竹中 志保, 草野 研吾, 久松 研一, 永瀬 聡, 大田 恵子, 中村 一文, 森田 宏, 松原 広己, 江森 哲郎, 大江 透

    Japanese circulation journal   65   673 - 673   2001.4

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  • 101) 自律神経障害により発作性上室性頻拍から心室細動を来したWPW症候群の一例

    湯本 晃久, 草野 研吾, 永瀬 聡, 竹中 志保, 中村 一文, 森田 宏, 江森 哲朗, 松原 広己, 大江 透, 松原 奎一

    Japanese circulation journal   65   671 - 671   2001.4

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  • 113) 先天性QT延長症候群患者のNaチャネル遮断薬に対する反応

    森田 宏, 草野 研吾, 永瀬 聡, 中村 一文, 大田 恵子, 小林 誠, 山本 美香, 竹中 志保, 江森 哲郎, 松原 広己, 大江 透

    Japanese circulation journal   65   672 - 672   2001.4

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  • 68) 心房粗動での体表面電位図の有効性

    森田 宏, 草野 研吾, 垣下 幹夫, 中村 一文, 藤本 良久, 山本 美香, 竹中 志保, 久松 研一, 宮地 維克, 松原 広己, 山成 洋, 大江 透

    Japanese circulation journal   64   939 - 939   2000.10

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  • 92) 拡張型心筋症患者の心筋組織からのアデノウイルスの検出

    中村 一文, 草野 研吾, 中村 陽一, 松原 広己, 山成 洋, 森田 宏, 藤本 良久, 大江 透, 山田 雅夫

    Japanese circulation journal   64   942 - 942   2000.10

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  • 116) Antidromic型房室回帰性頻拍の一例

    永瀬 聡, 草野 研吾, 中村 一文, 大江 透, 佐藤 博彦

    Japanese circulation journal   64   822 - 822   2000.4

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  • P412 拡張型心筋症におけるカルベジロールの再分極過程への影響

    竹中 志保, 山成 洋, 中村 一文, 森田 宏, 草野 研吾, 松原 広己, 大江 透

    Japanese circulation journal   64   562 - 562   2000.3

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  • P261 QT延長症候群におけるT wave alternans心電図の特徴

    森田 宏, 草野(福島) 研吾, 垣下 幹夫, 中村 一文, 藤本 良久, 山本 美香, 永瀬 聡

    Japanese circulation journal   64   524 - 524   2000.3

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  • P090 拡張型心筋症におけるMCP-1の心筋発現と心機能との相関

    中村 一文, 草野 研吾, 中村 陽一, 垣下 幹夫, 藤本 良久, 森田 宏, 松原 広己, 山成 洋, 大江 透

    Japanese circulation journal   64   481 - 481   2000.3

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  • P899 rasファルネシル化阻害剤, Manumycin Aによる血管平滑筋細胞の増殖および遊走抑制効果

    河内 裕輔, 中村 一文, 森田 宏, 草野 研吾, 松原 広己, 山成 洋, 大江 透, 難波 正義

    Japanese circulation journal   64   684 - 684   2000.3

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  • 0870 ACE阻害薬投与高血圧症例の内皮機能におけるシクロオキシゲナーゼ依存性因子の関与

    山成 洋, 中村 一文, 垣下 幹夫, 森田 宏, 草野 研吾, 松原 広己, 大江 透

    Japanese circulation journal   64   404 - 404   2000.3

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  • 0455 QT延長症候群におけるT wave alternansの特徴

    森田 宏, 草野(福島) 研吾, 垣下 幹夫, 中村 一文, 藤本 良久, 山本 美香, 竹中 志保, 松原 広己, 山成 洋, 大江 透

    Japanese circulation journal   64   299 - 299   2000.3

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  • Evaluation of atherosclerosis in hemodialysis patients: Significance of monocyte chemoattractant protein-1 for carotid arterial sclerosis.:Significance of monocyte chemoattractant protein-1 for carotid arterial sclerosis

    Kusano Kengo Fukushima, Nakamura Kazufumi, Nakamura Yoichi, Ohe Tohru, Kusano Hitoshi, Kusano Isao

    Journal of Japanese Society for Dialysis Therapy   33 ( 9 )   1245 - 1249   2000

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    Recently, monocyte infiltration into the vessel wall mediated by monocyte chemoattractant protein-1 (MCP-1) is a key initial step in the process of atherosclerosis. We investigated factors that affect atherosclerosis in chronic hemodialysis patients and examined the effect of MCP-1 on atherosclerosis. Ultrasonic carotid arteriography was performed to evaluate the degree of atherosclerosis. To exclude the influence of the cause of the disease, patients with diabetic nephropathy and hypertensive nephrosclrosis were excluded. A total of 52 patients (29 men and 23 women; age, 56±10 years; mean duration of hemodialysis, 10.1±7.4 years) were entered in this study. The degree of arterial sclerosis was evaluated by the degree of intimal-medial thickness (IMT) in the carotid arteries. Age, duration of hemodialysis, left ventricular hypertrophy (LVH), smoking, lipid profiles, lipoprotein (a), uric acid, fibrinogen, homocystein, and MCP-1 were investigated as possible factors affecting atherosclerosis. They were compared with the mean value of IMT. A 12-lead ECG was used to evaluate three degrees of LVH: normal range, only high voltage, and high voltage with ST change. Age, LVH, smoking and MCP-1 were found to be significantly correlated with the mean value of IMT. However, the correlation of other variables was insignificant. Multiple linear regression analysis revealed age, LVH, MCP-1 and apolioprotein A-1 to be the independent factors affecting the mean value of IMT. These findings suggest that MCP-1 is sensitive marker for atherosclerosis in patients with chronic hemodialysis.

    DOI: 10.4009/jsdt.33.1245

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  • Sympathetic Stimulation Produces a Greater Increase in Both Transmural and Spatial Dispersion of Repolarization in LQT1 Than LQT2 Forms of Congenital Long QT Syndrome.

    Tanabe Y, Inagaki M, Kurita T, Nagaya N, Taguchi A, Suyama K, Aihara N, Kamakura S, Sunagawa K, Nakamura K, Ohe T

    JACC   2000

  • Hepatitis C virus infection in a patient with dermatomyositis and left ventricular dysfunction

    K. Nakamura, A. Matsumori, K. F. Kusano, K. Banba, M. Taniyama, Y. Nakamura, H. Morita, H. Matsubara, H. Yamanari, T. Ohe

    Japanese Circulation Journal   64 ( 8 )   617 - 618   2000

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    Hepatitis C virus (HCV) infection is frequently associated with autoimmune disease. We present here a case of dermatomyositis manifested as heart failure in which HCV was detected from an endomyocardial biopsy sample. HCV infection may have contributed to the left ventricular dysfunction in this patient with dermatomyositis.

    DOI: 10.1253/jcj.64.617

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  • Effects of Low-Dose Aspirin on Endothelial Function in Hypertensive Patients.

    Monobe H, Yamanari H, Nakamura K, Ohe T

    Clin. Cardiol   2000

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  • Involvement of Ca2+ in antiarrhythmic effect of ischemic preconditioning in isolated rat heart

    Kui Hong, Kengo Fukushima Kusano, Hiroshi Morita, Yoshihisa Fujimoto, Kazufumi Nakamura, Hiroshi Yamanari, Tohru Ohe

    Japanese Journal of Physiology   50 ( 2 )   207 - 213   2000

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    We investigated the relationship between the effects of ischemic preconditioning (IPC) and Ca2+ preconditioning (CPC) on reperfusion-induced arrhythmias. In the control group (noPC), Langendorff-perfused rat hearts were subjected to 5-min zero-flow global ischemia (I) followed by 15-min reperfusion (I/R). In ischemic preconditioning groups (IPC), the hearts were subjected to three cycles of 3-min global ischemia and 5-min reperfusion. In the CPC group, the hearts were exposed to three cycles of 3-min perfusion of higher Ca2+ (2.3 mmol/l Ca2+) followed by 5-min perfusion of normal 1.3 mmol/l Ca2+, and the hearts were then subjected to I/R. Verapamil was administered in several hearts of the IPC group (VR+IPC). Ventricular arrhythmias upon reperfusion were less frequently seen in the IPC and CPC groups than in the noPC and VR+IPC groups. IPC and CPC could attenuate conduction delay and enhance shortening of the monophasic action potential duration during ischemia. The ventricular fibrillation threshold measured at 1-min reperfusion was significantly higher in the IPC and CPC groups than in the noPC and VR+IPC groups. Verapamil completely abolished the salutary effects of IPC. These results demonstrate that Ca2+ plays an important role in the antiarrhythmic effect of IPC during reperfusion.

    DOI: 10.2170/jjphysiol.50.207

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  • Hepatitis C virus infection in a patient with dermatomyositis and left ventricular dysfunction

    K. Nakamura, A. Matsumori, K. F. Kusano, K. Banba, M. Taniyama, Y. Nakamura, H. Morita, H. Matsubara, H. Yamanari, T. Ohe

    Japanese Circulation Journal   64 ( 8 )   617 - 618   2000

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    Hepatitis C virus (HCV) infection is frequently associated with autoimmune disease. We present here a case of dermatomyositis manifested as heart failure in which HCV was detected from an endomyocardial biopsy sample. HCV infection may have contributed to the left ventricular dysfunction in this patient with dermatomyositis.

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  • Relatively Benign Clinical Course in Asymptomatic Patients with Brugada-Type Electrocardiogram Without Family History of Sudden Death.

    Takenaka S, Fukushima K K, Hisamatsu K, Nagase S, Nakamura K, Morita H, Matsubara H, Emori T, Ohe T

    Journal of Cardiovascular Electrophysiology   2000

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  • Lone AFにおける心房心筋炎の関与.

    草野研吾, 中村陽一, 中村一文, 垣下幹夫, 永瀬 聡, 斉藤博則, 松原広己, 山成 洋, 大江 透, 磯村寛樹, 山田雅夫

    Therapeutic Research   22,3,29-32   2000

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  • Involvement of Ca2+ in antiarrhythmic effect of ischemic preconditioning in isolated rat heart

    Kui Hong, Kengo Fukushima Kusano, Hiroshi Morita, Yoshihisa Fujimoto, Kazufumi Nakamura, Hiroshi Yamanari, Tohru Ohe

    Japanese Journal of Physiology   50 ( 2 )   207 - 213   2000

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    We investigated the relationship between the effects of ischemic preconditioning (IPC) and Ca2+ preconditioning (CPC) on reperfusion-induced arrhythmias. In the control group (noPC), Langendorff-perfused rat hearts were subjected to 5-min zero-flow global ischemia (I) followed by 15-min reperfusion (I/R). In ischemic preconditioning groups (IPC), the hearts were subjected to three cycles of 3-min global ischemia and 5-min reperfusion. In the CPC group, the hearts were exposed to three cycles of 3-min perfusion of higher Ca2+ (2.3 mmol/l Ca2+) followed by 5-min perfusion of normal 1.3 mmol/l Ca2+, and the hearts were then subjected to I/R. Verapamil was administered in several hearts of the IPC group (VR+IPC). Ventricular arrhythmias upon reperfusion were less frequently seen in the IPC and CPC groups than in the noPC and VR+IPC groups. IPC and CPC could attenuate conduction delay and enhance shortening of the monophasic action potential duration during ischemia. The ventricular fibrillation threshold measured at 1-min reperfusion was significantly higher in the IPC and CPC groups than in the noPC and VR+IPC groups. Verapamil completely abolished the salutary effects of IPC. These results demonstrate that Ca2+ plays an important role in the antiarrhythmic effect of IPC during reperfusion.

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  • Manumycin A, inhibitor of ras farnesyltransferase, inhibits proliferation and migration of rat vascular smooth muscle cells

    Hirosuke Kouchi, Kazufumi Nakamura, Kazuo Fushimi, Masakiyo Sakaguchi, Masahiro Miyazaki, Tohru Ohe, Masayoshi Namba

    Biochemical and Biophysical Research Communications   264 ( 3 )   915 - 920   1999.11

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    Restenosis after angioplasty is thought to be caused by proliferation and migration of vascular smooth muscle cells (VSMCs), and it is a most serious problem in medical treatment. A low dose (50 ng/ml) of manumycin A, an inhibitor of p21(ras) (ras) farnesylation, significantly inhibited proliferation of rat VSMCs stimulated by the platelet-derived growth factor (PDGF). The mitoinhibitory effect of manumycin A was dose- and time-dependent but was independent of cell density. Western blot analysis showed that manumycin A reduced the amount of functional ras localized at the cytoplasmic membrane and inhibited the phosphorylation of p42/44 mitogen-activated protein kinase (MAPK). Manumycin A also inhibited VSMC migration and disorganized α actin fibers, as shown by immnofluorecence staining. These results indicate that the interruption of the ras/MAPK signal transduction pathway and the disorganization of α actin fibers are the main cause of manumycin A inhibition of VSMC proliferation and migration induced by PDGF.

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  • Manumycin A, inhibitor of ras farnesyltransferase, inhibits proliferation and migration of rat vascular smooth muscle cells

    Hirosuke Kouchi, Kazufumi Nakamura, Kazuo Fushimi, Masakiyo Sakaguchi, Masahiro Miyazaki, Tohru Ohe, Masayoshi Namba

    Biochemical and Biophysical Research Communications   264 ( 3 )   915 - 920   1999.11

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    Restenosis after angioplasty is thought to be caused by proliferation and migration of vascular smooth muscle cells (VSMCs), and it is a most serious problem in medical treatment. A low dose (50 ng/ml) of manumycin A, an inhibitor of p21(ras) (ras) farnesylation, significantly inhibited proliferation of rat VSMCs stimulated by the platelet-derived growth factor (PDGF). The mitoinhibitory effect of manumycin A was dose- and time-dependent but was independent of cell density. Western blot analysis showed that manumycin A reduced the amount of functional ras localized at the cytoplasmic membrane and inhibited the phosphorylation of p42/44 mitogen-activated protein kinase (MAPK). Manumycin A also inhibited VSMC migration and disorganized α actin fibers, as shown by immnofluorecence staining. These results indicate that the interruption of the ras/MAPK signal transduction pathway and the disorganization of α actin fibers are the main cause of manumycin A inhibition of VSMC proliferation and migration induced by PDGF.

    DOI: 10.1006/bbrc.1999.1546

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  • 24) 右室流出路起源特発性心室頻拍におけるQRS波形からみた起源の推定

    森田 宏, 福島 研吾, 中村 一文, 藤本 義久, 垣下 幹夫, 山成 洋, 大江 透

    Japanese circulation journal   63 ( 3 )   914 - 914   1999.10

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  • 83) Atriofascicular connectionのMahaim束の一例

    中村 一文, 福島 研吾, 伴場 主一, 垣下 幹夫, 森田 宏, 山成 洋, 大江 透

    Japanese circulation journal   63 ( 3 )   921 - 921   1999.10

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  • APICAL HYPERTROPHY ASSOCIATED WITH RAPID T-WAVE INVERSION ON THE ELECTROCARDIOGRAM

    H YAMANARI, D SAITO, K MIKIO, K NAKAMURA, T NANBA

    HEART AND VESSELS   10 ( 4 )   221 - 224   1995

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    A 53-year-old man who had no chest pain and no family history of heart disease demonstrated a rapid T wave change on an electrocardiogram, from a positive T wave to a giant negative T wave, within 1 year. Echocardiography showed no left ventricular hypertrophy before or after the T wave change. Cine-magnetic resonance imaging revealed focal apical hypertrophy after the appearance of the giant negative T wave. Although T wave inversions sometimes develop within a short period in patients with hypertrophic cardiomyopathy, they are rare in a patient without hypertension or chest pain.

    DOI: 10.1007/BF01744991

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  • APICAL HYPERTROPHY ASSOCIATED WITH RAPID T-WAVE INVERSION ON THE ELECTROCARDIOGRAM

    H YAMANARI, D SAITO, K MIKIO, K NAKAMURA, T NANBA

    HEART AND VESSELS   10 ( 4 )   221 - 224   1995

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    A 53-year-old man who had no chest pain and no family history of heart disease demonstrated a rapid T wave change on an electrocardiogram, from a positive T wave to a giant negative T wave, within 1 year. Echocardiography showed no left ventricular hypertrophy before or after the T wave change. Cine-magnetic resonance imaging revealed focal apical hypertrophy after the appearance of the giant negative T wave. Although T wave inversions sometimes develop within a short period in patients with hypertrophic cardiomyopathy, they are rare in a patient without hypertension or chest pain.

    DOI: 10.1007/BF01744991

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Presentations

  • Shear wave dispersion slope解析を用いた実験的心筋炎の重症度評価

    網岡尚史、高谷陽一、中村一文、近藤 恵、赤澤 薫、大野佑子、市川啓之、中山理絵、斎藤幸弘、赤木 達、吉田賢司、三好 亨、森田 宏、伊藤 浩

    第117回日本循環器学会中国地方会 

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    Event date: 2020.12.5 - 2020.12.6

  • 競技スポーツ中に異なる契機で心室細動をきたした若年男性の社会復帰例

    藤本竜平、森田 宏、駿河宗城、水野智文、横濱ふみ、角南春樹、宮本真和、中川晃志、西井伸洋、中村一文、伊藤 浩

    第117回日本循環器学会中国地方会 

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    Event date: 2020.12.5 - 2020.12.6

  • 肺高血圧症を契機に診断に至った高安動脈炎の一例

    佐々並三紗、内藤貴教、難波悠介、網岡尚史、増田拓郎、江尻健太郎、赤木 達、中村一文、森田 宏、志田原健太、内田治仁、伊藤 浩

    第117回日本循環器学会中国地方会 

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    Event date: 2020.12.5 - 2020.12.6

  • 乳癌治療中に著明な脂質異常症を呈し比較的若年で心筋梗塞を発症した一例

    中原清香、松尾直昭、網岡尚史、卜部 力、戸田洋伸、吉田雅言、三好 亨、中村一文、森田 宏、土井原博義、伊藤 浩

    第117回日本循環器学会中国地方会 

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    Event date: 2020.12.5 - 2020.12.6

  • 急性心不全の治療 up to date 2020

    中村一文, 赤木 達, 岩崎慶一朗, 伊藤 浩

    第24回日本心不全学会学術集会 

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    Event date: 2020.10.15 - 2020.10.17

  • Shear Wave Imagingを用いた心筋性状評価

    中山理絵, 高谷陽一, 中村一文, 網岡尚文, 大塚寛昭, 赤木 達, 吉田賢司, 三好 亨, 伊藤 浩

    日本超音波医学会第93回学術集会 

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    Event date: 2020.10.15 - 2020.10.17

  • Pemafibrate Reduces the Rupture of Experimental Aortic Aneurysm by Inhibiting Oxidative Stress

    Naofumi Amioka, Toru Miyoshi, Tomonari Kimura, Satoshi Akagi, Masashi Yoshida, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Itoh

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    Event date: 2020.7.31 - 2020.8.2

  • Evaluation of Myocardium Using Shear Wave Elastography in Monocrotaline-induced Pulmonary Hypertension Rat Heart

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    Event date: 2020.7.31 - 2020.8.2

  • Impact of Interleukin-6 on Severity and Myocardial Injury in Patients with Myocarditis

    Naofumi Amioka, Kazufumi Nakamura, Tomonari Kimura, Masashi Yoshida, Toru Miyoshi, Hiroshi Morita, Hiroshi Itoh

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    Event date: 2020.7.31 - 2020.8.2

  • Impact of Zero Coronary Artery Calcium Score on Favorable Prognosis in Nonalcoholic Fatty Liver Disease Patients

    Keishi Ichikawa, Toru Miyoshi, Takashi Miki, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Itoh

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    Event date: 2020.7.31 - 2020.8.2

  • Catheter Ablation of Atrial Fibrillation in Patients with Both Critical Left Ventricular Dysfunction and Serious Heart Failure

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    Event date: 2020.7.31 - 2020.8.2

  • Higher Oxidized HDL is Associated with High-risk Plaques Determined by CT Angiography in Patients with Suspected with Coronary Artery Disease

    Kazuki Suruga, Toru Miyoshi, Kazuhiko Kotani, Takashi Miki, Keishi Ichikawa, Kazuhiro Osawa, Hiroaki Otsuka, Masatoki Yoshida, Kazufumi Nakamura, Hiroshi Itoh

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    Event date: 2020.7.31 - 2020.8.2

  • Effect of Luseogliflozin and Voglibose on High-risk Lipid Profile in Diabetic Patients with Heart Failure: A Subanalysis of Randomized-controlled Trial

    Kentaro Ejiri, Toru Miyoshi, Hajime Kihara, Yoshiki Hata, Atsushi Takaishi, Hironobu Toda, Yoichi Nakamura, Satoshi Akagi, Satoru Sakuragi, Yusuke Kawai, Nobuhiro Nishii, Soichiro Fuke, Masaki Yoshikawa, Kazufumi Nakamura, Hiroshi Itoh

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    Event date: 2020.7.31 - 2020.8.2

  • Characteristics of Energy Metabolism in Pulmonary Artery Smooth Muscle Cells from Patients with Idiopathic Pulmonary Arterial Hypertension

    Satoshi Akagi, Kazufumi Nakamura, Kentaro Ejiri, Satoshi Hirohata, Hiroshi Itoh

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    Event date: 2020.7.31 - 2020.8.2

  • Modeling Marfan Syndrome with Induced Pluripotent Stem Cell-derived Vascular Smooth Muscle Cells

    Kazufumi Nakamura, Yukihiro Saito, Toru Miyoshi, Masashi Yoshida, Hironobu Toda, Hiroshi Itoh

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    Event date: 2020.7.31 - 2020.8.2

  • Epigenetic Effects of Hypoxia on Pathological Changes of SMCs from PAH with BMPR2 Mutation

    Kazufumi Nakamura, Satoshi Akagi, Yukihiro Saito, Kentaro Ejiri, Toru Miyoshi, Masashi Yoshida, Satoshi Hirohata, Hiroshi Itoh

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    Event date: 2020.7.31 - 2020.8.2

  • 心筋炎患者におけるIL-6の重症度および心筋傷害度への影響

    網岡尚史,中村一文,木村朋生,吉田賢司,三好 亨,森田 宏,伊藤 浩

    日本心臓リハビリテーション学会第5回中国支部地方会 

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    Event date: 2020.2.8

  • 術前のスクリーニング検査にて S-ICD 不適合の判定であったが,デバイス本体の設定により,植込み後,不適切作動を認めず経過している 1 例

    森本芳正、三好章仁、西井伸洋、水野智文、浅田早央莉、木村朋生、宮本真和、中川晃志、渡邊敦之、中村一文、森田 宏、伊藤 浩

    第12回植込みデバイス関連冬季大会 

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    Event date: 2020.2.6 - 2020.2.8

  • Auto Fusion AV delay 機能が心臓再同期療法における急性期の血行態に与える影響の評価

    宮本真和、西井伸洋、木村朋生、森本芳正、三好章仁、中川晃志、渡邊敦之、中村一文、森田 宏、伊藤 浩

    第12回植込みデバイス関連冬季大会 

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    Event date: 2020.2.6 - 2020.2.8

  • 特発性心室細動と心房細動の合併率についての検討

    水野智文、西井伸洋、木村朋生、森本芳正、宮本真和、中川晃志、渡邊敦之、中村一文、森田 宏、伊藤 浩

    第12回植込みデバイス関連冬季大会 

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    Event date: 2020.2.6 - 2020.2.8

  • Non-functional lead 抜去を施行した 2 例

    三好章仁、西井伸洋、水野智文、浅田早央莉、森本芳正、宮本真和、渡邊敦之、中村一文、森田 宏、伊藤 浩

    第12回植込みデバイス関連冬季大会 

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    Event date: 2020.2.6 - 2020.2.8

  • Fontan術後の複数の心房頻拍に対しRhythmiaによるカテーテルアブーションとTCPCconversionが奏効した1例

    森本芳正,西井伸洋,水野智文,浅田早央莉,木村朋生,宮本真和,中川晃志,渡邊敦之,中村一文,伊藤 浩,栄徳隆裕,笠原真悟

    第22回日本成人先天性心疾患学会総会・学術集会 

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    Event date: 2020.1.17 - 2020.1.19

  • 虚血性心疾患における酸化LDL値及び抗酸化LDL抗体価(第一報)

    第87回日本循環器学会中国・四国合同地方会  2205 

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  • 遠隔虚血プレコンディショニングは安定狭心症のPCI関連の急性腎障害を予防する:RINC Studyより

    第26回日本心血管インターベンション治療学会  2017 

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  • 安定狭心症でのPCI周術期心筋障害に対する遠隔臓器虚血プレコンディショニングの効果予測因子の解析

    第26回日本心血管インターベンション治療学会  2017 

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  • 安定狭心症患者の機能的狭窄評価におけるCT-FFRの使用経験

    第110回日本循環器学会中国・四国合同地方会  2017 

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  • Coronary Plaque Erosionが原因と考えられたAMIの1例

    第110回日本循環器学会中国・四国合同地方会  2017 

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  • Single Chamber ICDによりshock作動を起こした頻拍を、心臓電気生理学的検査にて上室頻拍と診断しえた1例

    第110回日本循環器学会中国・四国合同地方会  2017 

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  • His束近傍起源ATP感受性心房頻拍をentrainment pacingを指標に根治しえた1例

    第110回日本循環器学会中国・四国合同地方会  2017 

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  • 胸椎圧迫骨折が病態悪化に関与したと考えられた心房中隔欠損症によるPlatypnea-Orthodeoxia Syndromeの一例

    第110回日本循環器学会中国・四国合同地方会  2017 

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  • 異なる機序で生じた腹部大動脈狭窄3例、それぞれに対する治療戦略

    第110回日本循環器学会中国・四国合同地方会  2017 

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  • 動脈スティフネスと左室肥大の関連:新しい LV geometry 分類を用いた検討

    第81回日本循環器学会学術集会  2017 

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  • The Significance of Detailed Endocardial and Epicardial Mapping with Ventricular Tachyarrhythmias in Patients with Brugada syndrome.

    Heart Rhythm 2017  2017 

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  • 肺高血圧を伴う左右短絡心疾患に対するカテーテル治療

    第2回日本肺高血圧・肺循環学会  2017 

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  • 肺高血圧症患者の肺移植後右室リバースリモデリング:特異的肺動脈性肺高血圧症治療薬の併用療法後の検討

    第110回日本循環器学会中国・四国合同地方会  2017 

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  • Remote Ischemic Preconditioning Prevents Acute Renal Failure Following PCI in Patients with Stable Angina: Results from the Randomized RINC Study

    第81回日本循環器学会学術集会  2017 

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  • Plasma Lipoprotein (a) Level is an Independent Predictor of the Annual Progression of Coronary Calcium Score: Results from a Randomized Trial

    第81回日本循環器学会学術集会  2017 

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  • Prasugrel Decreased Peri-procedural Myocardial Injury by Strong Inhibition of Platelet Aggregation

    第81回日本循環器学会学術集会  2017 

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  • Diastolic Dysfunction is a Risk for Perioperative Myocardial Injury Assessed by High-sensitivity Cardiac Troponin T in Elderly Patients Undergoing Non-cardiac Surgery

    第81回日本循環器学会学術集会  2017 

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  • Factors for Ineligibility of Candidates for Subcutaneous Implantable Defbrillator in Patients with Brugada Syndrome

    第81回日本循環器学会学術集会  2017 

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  • Clinical Course of Pulmonary Artery Aneurysm in Pulmonary Hypertension: Insight into Medical Treatment and Histological Characteristics

    第81回日本循環器学会学術集会  2017 

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  • Effect of Remote Ischemic Preconditioning on Myocardial Injury Following PCI in Stable Angina Patients with Complex Coronary Lesions

    第81回日本循環器学会学術集会  2017 

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  • 労作時低酸素血症を合併したEbstein奇形に対する経皮的卵円孔閉鎖術

    第19回日本成人先天性心疾患学会総会・学術集会  2017 

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  • Impact of Stent Length on Myocardial Injury after PCI in Patients with Stable Angina: Results from the RINC Randomized Trial

    第81回日本循環器学会学術集会  2017 

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  • 心筋生検からみた二次性心筋症

    第21回日本心不全学会学術集会  2017 

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  • The Risk Factors for Predicting Ventricular Fibrillation in Asymptomatic Patients are Different from Those in Symptomatic Patients in Brugada Syndrome

    AHA  2017 

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  • 冠攣縮による陳旧性心筋梗塞巣からの心室頻拍を疑った1例

    第111回日本循環器学会中国地方会  2017 

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  • フレイルと左室肥大が急速に悪化の一途を辿った重症ASOの1例

    第111回日本循環器学会中国地方会  2017 

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  • 運動負荷試験中にwide QRS tachycardiaを来したBrugada症候群の1例

    第111回日本循環器学会中国地方会  2017 

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  • 心肺停止に至ったQT短縮症候群の1例

    第111回日本循環器学会中国地方会  2017 

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  • 重度低心機能患者に発症した重症下肢虚血、糖尿病性足壊疸に対し集学的治療を行った一例

    第111回日本循環器学会中国地方会  2017 

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  • ペースメーカーリード抜去術後に発症した、たこつぼ心筋症の1例

    第111回日本循環器学会中国地方会  2017 

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  • 肺動脈性肺高血圧症に合併した巨大肺動脈瘤に人工血管置換術を施行した一例

    第111回日本循環器学会中国地方会  2017 

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  • 僧帽弁形成術・Maze術後の心房頻拍に対して、Rhythmiaを用いてmappingを行い、RFCAを施行した1例

    第111回日本循環器学会中国地方会  2017 

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  • A TRPM4 Mutation in Patients with Ventricular Non- Compaction and Cardiac Conduction Disease

    Asian Pasific Heart Rhythm Society 2017  2017 

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  • Smart Pass will be the Gospel to Prevent Inappropriate Operation with S-ICD

    Asian Pasific Heart Rhythm Society 2017  2017 

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  • Refractory Repetitive Ventricular Tachycardia in Patients with Hypertrophic Cardiomyopathy

    Asian Pasific Heart Rhythm Society 2017  2017 

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  • 遠隔臓器プレコンディショニングの待機的PCIにおける心筋保護効果は喫煙者で増大する:ランダム化比較試験副次解析

    第65回日本心臓病学会学術集会  2017 

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  • 待機的PCI治療前後における血小板反応性の変化と関与する因子についての検討

    第65回日本心臓病学会学術集会  2017 

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  • 診断と治療が変わる心筋生検

    第21回日本心不全学会学術集会  2017 

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  • The Difference of The Intervention Rate Dependent on The Device Type in Cardiac Implantable Electric Devices Patients Followed by Remote Monitoring

    Asian Pasific Heart Rhythm Society 2017  2017 

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  • Significant Delayed Activation at Right Ventricular Outflow Tract Causes Upward Electrical Axis of the Right Ventricle and Complete Right Bundle Branch Block in Brugada Syndrome

    Asian Pasific Heart Rhythm Society 2017  2017 

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  • Ablation of Drug-Refractory Atrial Tachycardia Originated from the Mid-Proximal Portion of the Atrial Appendage

    Asian Pasific Heart Rhythm Society 2017  2017 

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  • 遠隔虚血プレコンディショニングは安定狭心症のPCI後の造影剤関連の急性腎障害を予防する:多施設共同ランダム化試験RINC study

    第65回日本心臓病学会学術集会  2017 

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  • スタチン加療中の高コレステロール血症患者において酸化HDLの増加は冠動脈石灰化を悪化させる

    第26回日本心血管インターベンション治療学会  2017 

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  • 安定狭心症患者でのPCI周術期心筋障害に対するステント長の影響

    第26回日本心血管インターベンション治療学会  2017 

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  • Remote ischemic preconditioning prevents contrast induced acute kidney injury in patients with stable coronary artery disease following elective PCI: results from the multicenter randomised study

    ESC2017  2017 

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  • Impact of coronary stent length on periprocedural myocardial injury after percutaneous coronary intervention for stable coronary artery disease: from the RINC randomized controlled trial data

    ESC2017  2017 

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  • Significant impact of type 2 diabetes mellitus on the association of arterial stiffness with left ventricular hypertrophy and left ventricular diastolic function

    ESC2017  2017 

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  • 顕性蛋白尿をきたした腎動脈狭窄症に対するPTRAの腎保護効果についての検討

    第24回日本心血管インターベンション治療学会中国・四国地方会  2017 

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  • 心房中隔欠損症患者における心房細動カテーテルアブレーション後の心房リモデリング

    カテーテルアブレーション関連大会2017  2017 

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  • 心筋梗塞亜急性期のVT Stormに対してSubstrateアブレーションが奏効した1例

    カテーテルアブレーション関連大会2017  2017 

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  • Comparison of renal outcome with renote ischemic preconditioning versus nicorandil following percutaneous coronary intervention in stable angina patients; results from the RINC trial

    ESC2017  2017 

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  • Effects of Tofogliflozin, an Sodium-glucose co-transporter 2 Inhibitor, on Cardiac Hypertrophy in Metabolic Model Rats

    ESC2017  2017 

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  • 虚血性心疾患患者における残余リスクと血管内皮機能障害との関連

    第49回日本動脈硬化学会総会・学術集会  2017 

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  • 特発性肺動脈性肺高血圧症に合併した巨大肺動脈瘤に対し人工血管置換術を施行した一例

    第110回日本循環器学会中国・四国合同地方会  2017 

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  • His束近傍の副伝導路に対して、Freezor Xtraにより根治しえた一例

    第110回日本循環器学会中国・四国合同地方会  2017 

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  • 成人先天性心疾患診療における循環器内科医の役割:成人先天性心疾患センター開設後の状況

    第110回日本循環器学会中国・四国合同地方会  2017 

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  • Decreased Epicardial Adipose Tissue Density Evaluated by MDCT in Patients with Coronary Artery Disease: Comparison with Histological Findings

    第80回日本循環器学会総会  2016 

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  • Combination of Flow-mediated Dilatation and Intima-media Thickness in the Brachial Artery is Useful for Risk Stratification of Cardiovascular Events

    第80回日本循環器学会総会  2016 

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  • Impact of Lesion Morphology on the Accuracy of Fractional Flow Reserve Computed from CT

    第80回日本循環器学会総会  2016 

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  • The Impact of Characteristic ST-T Morphology on the Occurrence of Ventricular Fibrillation in Hypothermic Patients with Osborn Wave

    第80回日本循環器学会総会  2016 

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  • Effects of Pure Sodium Channel Blocker Pilsicainide on Electrocardiographic and Electrophysiologic Parameters in Brugada Patients with or without SCN5A Mutation

    第80回日本循環器学会総会  2016 

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  • Prognostic Significance of Inferolateral Fragmented QRS in Patients with Brugada Syndrome

    第80回日本循環器学会総会  2016 

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  • Crucial Role of Receptor for Advanced Glycation End Products in Inappropriate Increase of Smooth Muscle Cells from Patients with PAH

    第80回日本循環器学会総会  2016 

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  • Combination of Intima-media Thickness and Flow-mediated Dilatation in the Brachial Artery Predict Coronary Stenosis and High-risk Plaque

    第80回日本循環器学会総会  2016 

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  • Impact of Preoperative Long-term Epoprostenol Therapy on Acute Adverse Events after Lung Transplantation for Pulmonary Arterial Hypertension

    第80回日本循環器学会総会  2016 

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  • Dipeptidyl Peptidase-4 Inhibitor, Sitagliptin Improves LV Diastolic Dysfunction in Type 2 Diabetes with Elevated Left Ventricular Filling Pressure

    第80回日本循環器学会総会  2016 

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  • Reduction of Right Ventricular Afterload by Lung Transplantation Reverses Ventricular Remodeling

    第80回日本循環器学会総会  2016 

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  • Clinical Practice of Right Heart Failure ―What is the Problem?

    第80回日本循環器学会総会  2016 

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  • Sufficient Reduction of Right Ventricular Afterload Plays an Indispensable Role in Right Ventricular Reverse Remodeling and Function: From the Aspect of Lung Transplantation in Patients with Pulmonary Arterial Hypertension

    第80回日本循環器学会総会  2016 

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  • How Do We Make Use of Endomyocardial Biopsy?

    第80回日本循環器学会総会  2016 

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  • Progress of Therapeutic Strategies for Pulmonary Artery Hypertension: Long-Term Effects of Treat and Repair for Adult Atrial Septal Defect

    第80回日本循環器学会総会  2016 

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  • Modeling Aortic Aneurysm in Marfan Syndrome with Induced Pluripotent Stem Cell-derived Smooth Muscle Cells

    第80回日本循環器学会総会  2016 

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  • ファブリー病

    第80回日本循環器学会総会  2016 

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  • Low Number of Circulating CD34 Positive Cell is Associated with Greater Progression of Coronary Calcium Determined by MDCT

    第80回日本循環器学会総会  2016 

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  • Triglyceride to HDL-C Ratio is a Novel Predictor of High Risk Coronary Plaque in Patients with Suspected Stable Angina Pectoris

    第80回日本循環器学会総会  2016 

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  • Intratracheal Administration of Prostacyclin Analog-incorporated Nanoparticles Ameliorates the Development of Monocrotaline and Sugen/Hypoxia-induced Pulmonary Arterial Hypertension

    第80回日本循環器学会総会  2016 

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  • The Triggering and Exacerbating Factors of Pulmonary Injury after Balloon Pulmonary Angioplasty for Patients with Chronic Thromboembolic Pulmonary Hypertension

    第80回日本循環器学会総会  2016 

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  • 心外膜リードシステムを用いて外科的に植込み型除細動器の植込みを行った小児の2例

    第8回植込みデバイス関連冬季大会  2016 

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  • Characteristics of Pulmonary Artery Smooth Muscle Cells of Patients with Idiopathic Pulmonary Arterial Hypertension

    The 9th international conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide  2016 

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  • Low number of circulating CD34 positive cell is associated with greater progression of coronary calcium determined by MDCT

    84th EAS CONGRESS  2016 

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  • QRS widening and fragmented QRS rise a risk of cardiac sarcoidosis in complete right bundle branch block patients

    Cardiostim EHRA Europace 2016  2016 

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  • FFR-CTの有用性と限界-実臨床における検討-

    第108回日本循環器学会中国・四国合同地方会  2016 

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  • High Incidence of Right to Left Shunt in Adult Patients with Atrial Septal Defect

    CSI2016  2016 

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  • 家族性高コレステロール血症を背景としたPolyvascular diseaseに対して血行再建術を施行した1例

    日本内科学会中国支部主催第115回中国地方会  2016 

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  • 繰り返すカテーテル感染のためトレプロスチニル持続静注から吸入イロプロストへ切り替えを試みた1例

    日本内科学会中国支部主催第115回中国地方会  2016 

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  • Reduction of Right Ventricular Pressure Overload by Lung Transplantation Reverses Right Ventricular Function and Remodeling in Patients with End-stage Pulmonary Arterial Hypertension

    AHA  2016 

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  • 肥大型心筋症と診断されていたミトコンドリア心筋症の1例

    日本内科学会中国支部主催第115回中国地方会  2016 

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  • 血管炎をbaseにした進行性の腎動脈狭窄に対して血管内治療を施行した1例

    日本内科学会中国支部主催第115回中国地方会  2016 

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  • 安定狭心症における待機的PCI周術期のニコランジル持続静注の効果と検討:RINC試験副次解析

    第64回日本心臓病学会学術集会  2016 

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  • 心筋生検で何が変わるか?

    第20回日本心不全学会学術集会  2016 

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  • LCZ696はイソプロテレノール持続投与によって誘発されるラット心筋線維化を抑制する

    第20回日本心不全学会学術集会  2016 

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  • Crucial Role of Receptor for Advanced Glycation End Products in Inappropriate Increase of Smooth Muscle Cells from Patients with PAH

    AHA  2016 

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  • 肝移植1年後生存に関与する潜在的門脈肺高血圧症の重要性

    日本超音波医学会第52回中国地方会学術集会第15回中国地方会講習会  2016 

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  • 大型血管炎をbaseにした進行性の腎動脈狭窄に対して血管内治療を施行した1例

    第23回日本心血管インターベンション治療学会中国・四国地方会  2016 

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  • 動脈スティフネスは左室拡張機能障害を介して心不全発症に関与する

    第64回日本心臓病学会学術集会  2016 

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  • 冠動脈ハイリスクプラークの予測におけるトリグリセリド/HDLコレステロール比の有用性について

    第64回日本心臓病学会学術集会  2016 

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  • Cardiac fusion imaging with computed tomography and doppler echocardiography in the assessment of right ventricular outflow tract obstruction in patients with adult congenital heart disease

    ESC Congress 2016  2016 

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  • Triglyceride to HDL-C ratio predicts high risk coronary plaques characterized with coronary CT angiography in patients with suspected coronary artery disease

    ESC Congress 2016  2016 

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  • The increase in arterial stiffness may change in left ventricular geometry and lead to heart failure with preserved ejection fraction

    ESC Congress 2016  2016 

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  • 治療開始20年後に再発を認めたカテコラミン誘発性多形性心室頻拍の一例

    第108回日本循環器学会中国・四国合同地方会  2016 

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  • 治療に難渋した壊死性好酸球性心筋炎(一部巨細胞浸潤を伴う)の一例

    第108回日本循環器学会中国・四国合同地方会  2016 

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  • 右冠動脈ステント内閉塞を繰り返した冠動脈肉腫の一例

    第108回日本循環器学会中国・四国合同地方会  2016 

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  • 不全心のリバース・リモデリング-症例から学ぶ治療による回復-

    CVMW2015  2015 

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  • 上腕動脈のIntima-media Thickness(IMT)、Flow-mediated Dilatation(FMD)と冠動脈CTにおけるハイリスクプラークとの関連

    第63回日本心臓病学会学術集会  2015 

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  • 左室拡張機能障害(LVDD)と上腕動脈内膜中膜複合体厚(IMT)ならびに血流依存性血管拡張反応検査 (FMD)の関連の検討

    第63回日本心臓病学会学術集会  2015 

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  • 外科的修復術を施行した肺高血圧症合併心室中隔欠損症の一例

    第4回日本肺循環学会/第3回日本肺高血圧学会合同学術集会  2015 

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  • 肺動脈性肺高血圧症におけるRAGEシグナルの亢進

    第4回日本肺循環学会/第3回日本肺高血圧学会合同学術集会  2015 

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  • スタチンの冠動脈石灰化の進展へ及ぼす効果についてマルチスライスCTを用いた前向き多施設共同研究(PEACH trial)

    第63回日本心臓病学会学術集会  2015 

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  • プロスタサイクリンによる右心機能改善の可能性

    第4回日本肺循環学会/第3回日本肺高血圧学会合同学術集会  2015 

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  • EpoprostenolからTreprostinilへ切り替えた重症肺高血圧症の一例

    第4回日本肺循環学会/第3回日本肺高血圧学会合同学術集会  2015 

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  • 植込み型デバイスの遠隔モニタリングによる心不全関連不整脈の臨床像

    第19回日本心不全学会学術集会  2015 

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  • Excess Proliferation and Apoptosis-resistance of Pulmonary Artery Smooth Muscle Cells from Patients with Pulmonary Arterial Hypertension

    第79回日本循環器学会学術集会  2015 

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  • The Significance of Positron Emission Tomography to Detect the Underlying Inflammatory Cardiomyopathy with Arrhythmogenicity

    第79回日本循環器学会学術集会  2015 

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  • TIR/BB-loop Mimetic AS-1 Inhibits Proliferation of Pulmonary Artery Smooth Muscle Cells from Patients with Pulmonary Arterial Hypertension

    第79回日本循環器学会学術集会  2015 

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  • 3cm大のvegetationを認めるも開胸することなく全抜去に成功したデバイス感染の1例

    第7回植込みデバイス関連冬季大会  2015 

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  • 高齢者における動脈スティフネスはLV geometryと左室拡張機能障害(LVDD)に関連する

    第26回日本心エコー図学会学術集会  2015 

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  • 2型糖尿病患者における血管内皮機能障害と左室肥大との関連

    第26回日本心エコー図学会学術集会  2015 

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  • 大動脈弁狭窄症、僧帽弁閉鎖不全症を合併し、弁置換術を施行したFabry病の一例

    第26回日本心エコー図学会学術集会  2015 

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  • 心臓CTを用いた成人2次孔欠損型心房中隔欠損症の評価に関する検討

    第25回日本心血管画像動態学会  2015 

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  • 心臓超音波検査による心臓周囲脂肪の厚みと冠動脈造影CTのハイリスクプラークの関連の検討

    第25回日本心血管画像動態学会  2015 

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  • PAH肺動脈平滑筋細胞のNOに対する反応性の検討

    第44回日本心脈管作動物質学会  2015 

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  • 重症不整脈源性右室心筋症に対するFontan手術の検討

    第17回日本成人先天性心疾患学会総会・学術集会  2015 

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  • 心房中隔欠損症患者における心房細動カテーテルアブレーション後の欠損孔の変化

    第17回日本成人先天性心疾患学会総会・学術集会  2015 

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  • 巨大右室を必須緩徐伝導路とするマクロリエントリー性心室頻拍を合併した成人Ebstein奇形の一例

    第17回日本成人先天性心疾患学会総会・学術集会  2015 

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  • Clinical characteristics of responders to treatment with tolvaptan in patients with acute decompensated heart failure: importance of preserved kidney size

    ESC2015  2015 

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  • Postoperative myocardial injury assessed by high-sensitivity cardiac troponin t and revised cardiac risk index in patients undergoing non-cardiac surgery

    ESC2015  2015 

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  • The number of circulating CD34 positive cell is an independent predictor of the annual progression of coronary calcium score determined by MDCT: Results from the PEACH trial

    ESC2015  2015 

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  • Epicardial fat density evaluated with MDCT is associated with cardio-metabolic risk factors

    ESC2015  2015 

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  • Right ventricular fractional area change obtained in different echocardiographic views. Comparison with right ventricular ejection fraction by cardiac magnetic resonance imaging

    ESC2015  2015 

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  • FMDを用いたResidual Risk 軽減の検討

    第63回日本心臓病学会学術集会  2015 

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  • Usefulness of Aortic Valve Area Measurement Obtained by Single-Beat Recording of Double–Envelope Technique in Patients With Aortic Stenosis and Atrial Fibrillation.

    ESC2015  2015 

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  • Outcomes in patients with probable cardiac sarcoidosis in comparison with definite cardiac sarcoidosis

    ESC2015  2015 

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  • Biological Pacemaker Created by HCN4-overexpressing Mouse Embryonic Stem Cell-derived Cardiomyocytes

    ESC2015  2015 

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  • Inhibitory effects of TIR/BB-loop mimetic AS-1 on Proliferation of Pulmonary Artery Smooth Muscle Cells from Patients with Pulmonary Arterial Hypertension

    ESC2015  2015 

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  • 先天性QT延長症候群の小児に対しICD植込みを行った1例

    第106回日本循環器学会中国・四国合同地方会  2015 

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  • 右房・左室内腔をほぼ占拠する腫瘤性病変を呈した子宮頸部扁平上皮癌の心臓転移の一例

    第106回日本循環器学会中国・四国合同地方会  2015 

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  • ファロー四徴症術後遠隔期にカテコラミン誘発性多形性心室頻拍の合併症が疑われICD植込みを行った1例

    第106回日本循環器学会中国・四国合同地方会  2015 

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  • 化学・放射線療法が奏効した原発性肺動脈血管内膜肉腫の1症例

    第106回日本循環器学会中国・四国合同地方会  2015 

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  • Effect Of Statin On The Progression Of Coronary Artery Calcification Detected By Computed Tomography (PEACH Trial)

    SCCT2015  2015 

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  • The increase in arterial stiffness may change in left ventricular geometry and lead to left ventricular diastolic dysfunction.

    ESC2015  2015 

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  • platypnea-orthodeoxia syndromeの患者に対して精査し、肝肺症候群・動静脈瘻に起因すると考えられた一例

    第106回日本循環器学会中国・四国合同地方会  2015 

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  • ステロイド開始・漸減中に再燃した好酸球性心筋炎の症例

    第106回日本循環器学会中国・四国合同地方会  2015 

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  • 3cm大のvegetationを認めるも開胸することなく全抜去に成功したデバイス感染の1例

    第106回日本循環器学会中国・四国合同地方会  2015 

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  • 当院で経験したPaget-Schroetter syndrome(PSS)の2例

    第106回日本循環器学会中国・四国合同地方会  2015 

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  • Left Ventricular Wall Thickness as a Risk-stratification Tool of Arrhythmic Event in Hypertrophic Cardiomyopathy Patients with ICD for Primary Prevention

    第79回日本循環器学会学術集会  2015 

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  • Doppler-derived Estimation of Pulmonary Vascular Resistance in Patients with Adult Congenital Heart Disease with Left to Right Shunting

    第79回日本循環器学会学術集会  2015 

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  • Effect of Preoperative Pulmonary Hypertension in Patients with Pulmonary Arterial Hypertension on Short-term Mortality after Lung Transplantation

    第79回日本循環器学会学術集会  2015 

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  • The Prognostic Factor of Death and Recurrent Ventricular Tachyarrhythmia in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy

    第79回日本循環器学会学術集会  2015 

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  • The Impact of the Drastic Elevation of the Sympathetic Activity by Abrupt Starting Exercise Protocol in Patients with Congenital Long QT Syndrome

    Heart Rhythm 2015  2015 

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  • Analysis of Endocardial Unipolar and Bipolar Electrograms in Non-ischemic and Ischemic Cardiomyopathy Patients with Ventricular Tachycardia

    Heart Rhythm 2015  2015 

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  • Inhibitory Effects of Eicosapentaenoic Acid on Arterial Calcification in Klotho Mutant Mice

    第79回日本循環器学会学術集会  2015 

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  • Assessment of Pulmonary Flow in Patients with Pulmonary Hypertension by Quantification of Lung Perfusion Blood Volume in Dual-energy Computed Tomography

    第79回日本循環器学会学術集会  2015 

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  • Reduction of Right Ventricular Afterload by Lung Transplantation Improves Right Ventricular Dilatation and Hypertrophy

    第79回日本循環器学会学術集会  2015 

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  • Development of Atrial Tachyarrhythmias and Its Associated Factor after Extracardiac Fontan Procedure in Adults

    第79回日本循環器学会学術集会  2015 

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  • The Significance of Delayed Gadolinium Enhancement in Cardiac Magnetic Resonance Imaging in Patients with Preserved Left Ventricular Function

    第79回日本循環器学会学術集会  2015 

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  • Usefulness of Epicardial Adipose Thickness by Echocardiography as a Predictor for High Risk Coronary Plaque Determined by Coronary CT Angiography

    第79回日本循環器学会学術集会  2015 

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  • The Worse Prognosis of Dilated Hypertrophic Cardiomyopathy Patients Treated with Cardiac Resynchronization Therapy―Comparison with Other Non-ischemic Cardiomyopathy Patients

    第79回日本循環器学会学術集会  2015 

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  • Serum Cystatin C Levels is a Significant Predictor of Coronary Artery Calcification in Women with Preserved Renal Function

    第79回日本循環器学会学術集会  2015 

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  • Epicardial Fat Quality Determined as CT Attenuation are Associated with Cardio-metabolic Risk Factors

    第79回日本循環器学会学術集会  2015 

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  • Intra Myocardial Adiposity could Predict Left Ventricular Diastolic Dysfunction in Patients without History of Coronary Artery Disease

    第79回日本循環器学会学術集会  2015 

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  • Genotype-specific QTadaptation at Exercise in Long QT Syndrome. Comparison between LQTS with TdP and LQTS without TdP

    第79回日本循環器学会学術集会  2015 

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  • Remote Ischemic Preconditioning Reduced the Incidence of Contrast-induced Nephropathy in High-risk Patients with ST-elevation Myocardial Infarction

    第79回日本循環器学会学術集会  2015 

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  • A New Parameter, Brachial Intima-Media Thickness is Associated with High-Risk Plaque Determined by MDCT

    第79回日本循環器学会学術集会  2015 

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  • Cardiac CT could Evaluate the Essential Measures of Secundum Atrial Septal Defect in Adult Patients

    第79回日本循環器学会学術集会  2015 

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  • Biological Pacemaker Created by HCN4-overexpressing Mouse Embryonic Stem Cell-derived Cardiomyocytes

    第79回日本循環器学会学術集会  2015 

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  • Association between Histological Findings in Epicardial Adipose and Perivascular Adipose Tissue at LITA and MDCT Parameters in Coronary Artery Disease

    第79回日本循環器学会学術集会  2015 

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  • Role of Oxidative Stress in Atrial Fibrillation―Clinical, Histological and Experimental Examination―

    第79回日本循環器学会学術集会  2015 

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  • 薬剤負荷心電図で診断されたカテコラミン誘発性多形性心室頻拍の1例

    第24回日本不整脈学会学術大会・第26回日本心電学会学術集会 合同学術集会  2009 

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  • Differential Effects of Genotype on the Initiation of Ventricular Arrhythmia in Patients with Brugada Syndrome

    第73回日本循環器学会総会・学術集会  2009 

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  • Serum Cyctatin C Reflects Cardiac Diastolic Dysfunction in Patients with Heart Failure

    第73回日本循環器学会総会・学術集会  2009 

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  • AA/EPA is a Strong Indicator of Plaque Vulnerability in Both ACS and SAP: A Study with VH-IVUS

    第73回日本循環器学会総会・学術集会  2009 

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  • Clinical Usefulness of Serial ECG Recordings in Brugada Syndrome

    第73回日本循環器学会総会・学術集会  2009 

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  • Atrial Electrophysiological and Structural Characteristics in High-Risk Patients with Brugada Syndrome

    第73回日本循環器学会総会・学術集会  2009 

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  • Association Cystatin C Indicates the Severity of Sleep Apnea in Patients with Cardiovascular Disease

    第73回日本循環器学会総会・学術集会  2009 

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  • Comparison of Clinical Characteristics between the Patients with Connective Tissue Disease and Idiopathic Pulmonary Arterial Hyptertension

    第73回日本循環器学会総会・学術集会  2009 

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  • Red Blood Cell Distribution Width Reflects Heart Failure Status in Patients with Idiopathic Pulmonary Arterial Hypertension

    第73回日本循環器学会総会・学術集会  2009 

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  • Relationship between Serum Oxidized Low-Density Lipoprotein / β2-glycoprotein ⅠComplexes and Other Risk Factors for Atherosclerosis and