Faculty Profiles - KONDOU Yoshitaka

Papers - KONDOU Yoshitaka

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下部消化管超高齢者(95歳)の進行盲腸癌に対し腹腔鏡下回盲部切除を施行した1例

渡邉彩子, 稲田涼, 永坂岳司, 八木朝彦, 松本聖, 戸嶋俊明, 母里淑子, 近藤喜太, 岸本浩行, 藤原俊義

日本外科学会定期学術集会抄録集 115回 RS - 1 2015.4

A successful multimodality therapy for a case of recurrent rectal cancer with KRAS mutation Reviewed

Ayako Watanabe, Ryo Inada, Takeshi Nagasaka, Tomohiko Yagi, Hijiri Matsumoto, Toshiaki Toshima, Yoshiko Mori, Yoshitaka Kondo, Hiroyuki Kishimoto, Toshiyoshi Fujiwara

Japanese Journal of Cancer and Chemotherapy 42 ( 2 ) 237 - 239 2015.2

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Journal of Cancer and Chemotherapy Publishers Inc.

Aman in his 50s underwent high anterior resection for rectosigmoid cancer in January 2010. The primary tumor was diagnosed as a moderately differentiated adenocarcinoma with KRAS mutation, pStage a. In May 2011, the patient had a recurrent lung tumor detected by computed tomography (CT)
the tumor was resected using video-assisted thoracoscopic surgery. However, additional recurrent lung tumors arose, and radiofrequency ablation (RFA) was performed to treat these in Febuary 2012. After RFA therapy, capecitabine was administered as adjuvant chemotherapy. Unfortunately, 10 months later, positron emission tomography (PET)/cT suggested a new recurrence in a left lateral lymph node. Although the pelvic lymph node was surgically removed immediately, a new lung recurrence was found on CT three months after the surgery. RFA was again used to treat this lung lesion. After the second RFA, the patient is doing well without any evidence of recurrence. We describe a case of recurrent rectal cancer successfully treated with multimodality therapy. The combination of appropriate locai therapy with systemic chemotherapy is an essential strategy to treat advanced colorectal cancer, especially in patients witl KRAS mutation when anti-EGFR antibodies are not effective.

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A case of appendix cancer treated as cancer of unknown primary origin Reviewed

Hijiri Matsumoto, Ryo Inada, Takeshi Nagsaka, Ayako Watanabe, Tomohiko Yagi, Toshiaki Toshima, Yoshiko Mori, Yoshitaka Kondo, Hiroyuki Kishimoto, Toshiyoshi Fujiwara

Japanese Journal of Cancer and Chemotherapy 42 ( 2 ) 229 - 231 2015.2

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Journal of Cancer and Chemotherapy Publishers Inc.

A 57-year-old man initially presented with chief complaints of abdominal distension and anorexia. Positron emission tomography-computed tomography (PET-CT) scan showed ascites and multiple peritoneal metastases with abnormal uptake of fltiorodeoxyglucose (FDG). The patient underwent endoscopy, biopsy, and cytology and was diagnosed with adenocarcinom of unknown primary origin. He was treated with systematic chemotherapy, including carboplatin/paclitaxel (CBDCA/ PTX) and gemcitabine regimens. However, progressive disease (PD) complicated by intestinal obstruction was indicated. He was referred to our department for management. We performed surgery to resolve the intestinal obstruction and confirm the diagnosis. Appendix cancer was diagnosed intraoperatively. He was administered a modified fluorouracil plus Leucovorin and oxaliplatin (mFOLFOX6)/panitumumab regimen following surgery. The tumor had a good response to treatment, and the primry lesion was resected. After resection, the tumor was controlled by systemic chemotherapy for six months. However, the patient unfortunately died owing to arrhythmia. Most patients with cancer of unknown primary origin have a very poor prog1osis because it is difficult to select appropriate treatment. Laparotomy can be effective in making a definitive diagnosis, as inthe case described here.

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集学的治療にて長期生存を得たKRAS遺伝子変異を伴う再発直腸癌の1例

渡邉彩子, 稲田涼, 永坂岳司, 八木朝彦, 松本聖, 戸嶋俊明, 母里淑子, 近藤喜太, 岸本浩行, 藤原俊義

癌と化学療法 42 ( 2 ) 237 - 239 2015.2

Language：Japanese Publisher：(株)癌と化学療法社

進行・再発大腸癌に対する新規抗癌剤や分子標的薬の登場により多くの患者が生存期間の延長を得られるようになった。しかしさらなる長期生存を得るためには全身化学療法のみではなく、転移巣に対する局所療法も組み合わせる必要がある。とりわけKRAS変異を伴う大腸癌は有効薬剤が限られるため、より集学的な治療が必要となる。今回われわれは、KRAS変異を伴う直腸癌術後肺再発・骨盤内リンパ節再発を来した50代の男性に対して全身化学療法に加え、肺切除、経皮的ラジオ波焼灼術(radiofrequency ablation:RFA)、リンパ節切除といった集学的治療を行うことにより、初回再発時より3年以上、活動性病変のない状態で生存している症例を報告する。(著者抄録)

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Other Link： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2015&ichushi_jid=J00296&link_issn=&doc_id=20150219340021&doc_link_id=%2Fab8gtkrc%2F2015%2F004202%2F022%2F0237-0239%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fab8gtkrc%2F2015%2F004202%2F022%2F0237-0239%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

原発不明癌として治療を受けていた虫垂癌の1例

松本聖, 稲田涼, 永坂岳司, 渡邉彩子, 八木朝彦, 戸嶋俊明, 母里淑子, 近藤喜太, 岸本浩行, 藤原俊義

癌と化学療法 42 ( 2 ) 229 - 231 2015.2

Language：Japanese Publisher：(株)癌と化学療法社

われわれは原発不明癌として治療を受けていたが増悪し、開腹手術による確定診断後にmodified FOLFOX6(mFOLFOX6)+panitumumab療法を施行し、部分寛解となり原発巣切除となった症例を経験したので報告する。症例は50歳台、男性。腹部膨満、食思不振を主訴に前医受診。腹水貯留を伴う腹膜結節を認め癌性腹膜炎と診断された。腹水細胞診の結果、消化管由来と診断される腺癌を認めたが、PET-CT検査、上下部消化管内視鏡検査にて原発巣の診断は得られなかった。原発不明癌としてCBDCA+PTX療法、GEM療法にて加療するも腹水増大し、播種結節に伴う腸管閉塞を認め、2013年1月当院を紹介された。腸閉塞解除目的で開腹手術施行。腹腔内は虫垂の壁肥厚および播種による回腸末端付近の閉塞を認めたため、回腸人工肛門造設および播種結節切除を行った。虫垂癌の診断を得て、mFOLFOX6+panitumumab療法を3コース施行し、部分寛解を得た後、再び開腹し、拡大右半結腸切除術にて原発巣および一部播種結節を切除した。現在、原発不明癌に対しては標準的治療レジメンが存在しないばかりか、化学療法によって患者の予後改善を得られるのかも明確ではない。確定診断を得るためにも可能であれば開腹手術を考慮する必要がある。(著者抄録)

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Other Link： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2015&ichushi_jid=J00296&link_issn=&doc_id=20150219340019&doc_link_id=%2Fab8gtkrc%2F2015%2F004202%2F020%2F0229-0231%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fab8gtkrc%2F2015%2F004202%2F020%2F0229-0231%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Endoscopic radial incision and cutting method for refractory stricture of a rectal anastomosis after surgery Reviewed

Keita Harada, Seiji Kawano, Sakiko Hiraoka, Yoshiro Kawahara, Yoshitaka Kondo, Hiroyuki Okada

ENDOSCOPY 47 E552 - E553 2015

A Case of Intestinal Penetration Due to Small Intestinal Recurrence of Cecal Cancer

Watanabe Ayako, Inada Ryo, Nagasaka Takeshi, Yagi Tomohiko, Matsumoto Hijiri, Toshima Toshiaki, Mori Yoshiko, Kondo Yoshitaka, Kishimoto Hiroyuki, Fujiwara Toshiyoshi

Nihon Gekakei Rengo Gakkaishi (Journal of Japanese College of Surgeons) 40 ( 2 ) 251 - 255 2015

Language：Japanese Publisher：Japanese College of Surgeons

We report herein a case of solitary small intestinal recurrence of colorectal cancer. A man in his 70s underwent ileocecal resection with regional lymph node dissection for cecal cancer at Okayama University Hospital in December 2004. The tumor was diagnosed as moderately differentiated adenocarcinoma, and graded as pStage Ⅱ (pT2pN0cM0) according to the Japanese Classification of Colorectal Carcinoma, eighth edition. Thirty-six months after initial surgery, he presented complaining of severe abdominal pain and high fever. Abdominal computed tomography showed localized intra-abdominal abscess. Based on the diagnosis of intestinal penetration, we performed an emergent operation. Intraoperatively, a small intestinal tumor was found to be the cause of the penetration; therefore, both partial resection of the ileum and abscess drainage were performed. Although the patient underwent adjuvant chemotherapy, the tumor recurred in the retroperitoneum in November 2008. He then underwent multimodal therapy, including palliative local resection, radiotherapy, and systemic chemotherapy, to the site of recurrence; however, he died of the cancer about six years after initial recurrence.

DOI： 10.4030/jjcs.40.251

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Other Link： http://search.jamas.or.jp/link/ui/2015332071

手術の教育法開胸・開腹vs内視鏡下手術教育におけるカダバートレーニングの有用性と可能性

近藤喜太, 信岡大輔, 黒田新士, 前田直見, 藤原俊義

日本臨床外科学会雑誌 75 ( 増刊 ) 311 - 311 2014.10

集学的治療にて長期生存を得たKRAS遺伝子変異を伴う再発直腸癌の1例

渡邉彩子, 稲田涼, 永坂岳司, 八木朝彦, 松本聖, 戸嶋俊明, 母里淑子, 近藤喜太, 岸本浩行, 藤原俊義

日本臨床外科学会雑誌 75 ( 増刊 ) 843 - 843 2014.10

結腸腸間膜デスモイド線維腫症の1例

八木朝彦, 稲田涼, 永坂岳司, 渡邉彩子, 松本聖, 戸嶋俊明, 母里淑子, 近藤喜太, 岸本浩行, 藤原俊義

日本臨床外科学会雑誌 75 ( 増刊 ) 859 - 859 2014.10

高齢者大腸癌に対するD3郭清の短期・長期成績の検討

稲田涼, 永坂岳司, 渡邉彩子, 八木朝彦, 松本聖, 母里淑子, 近藤喜太, 岸本浩行, 浅野博昭, 佃和憲, 藤原俊義

日本臨床外科学会雑誌 75 ( 増刊 ) 640 - 640 2014.10

進行直腸癌術後再発に対して積極的な集学的治療によって長期生存を得た1例

松本聖, 稲田涼, 永坂岳司, 八木朝彦, 渡邉彩子, 戸嶋俊明, 母里淑子, 近藤喜太, 岸本浩行, 藤原俊義

日本臨床外科学会雑誌 75 ( 増刊 ) 843 - 843 2014.10

Miles手術における会陰創のSSIに対するVAC療法の経験

戸嶋俊明, 近藤喜太, 稲田涼, 母里淑子, 岸本浩行, 永坂岳司, 藤原俊義

日本臨床外科学会雑誌 75 ( 増刊 ) 440 - 440 2014.10

クローン病に対する腹腔鏡下手術の成績開腹手術と比較して

戸嶋俊明, 近藤喜太, 稲田涼, 母里淑子, 岸本浩行, 永坂岳司, 藤原俊義

日本内視鏡外科学会雑誌 19 ( 7 ) 578 - 578 2014.10

Colitic cancer/high grade dysplasiaを合併した潰瘍性大腸炎に対する腹腔鏡下大腸全摘の治療成績の検討

稲田涼, 近藤喜太, 母里淑子, 岸本浩行, 永坂岳司, 藤原俊義

日本内視鏡外科学会雑誌 19 ( 7 ) 506 - 506 2014.10

Intussusception due to rectal adenocarcinoma in a young adult: A case report Reviewed

Ryo Inada, Takeshi Nagasaka, Toshiaki Toshima, Yoshiko Mori, Yoshitaka Kondo, Hiroyuki Kishimoto, Toshiyoshi Fujiwara

WORLD JOURNAL OF GASTROENTEROLOGY 20 ( 35 ) 12678 - 12681 2014.9

Language：English Publishing type：Research paper (scientific journal) Publisher：BAISHIDENG PUBLISHING GROUP INC

An intussusception due to colonic adenocarcinoma has sometimes been reported. However, to the best of our knowledge, reports of intussusception due to rectal adenocarcinoma are extremely rare. In this report, the case of a young man with rectal adenocarcinoma causing intussusception is described. A 24-year-old man visited a hospital complaining of abdominal pain, and an upper rectal cancer was diagnosed by colonoscopy. Computed tomography showed intussusception caused by a large tumor in the pelvis and absence of distant metastases. Locally advanced rectal cancer causing intussusception was diagnosed, and a low anterior resection was performed. Intraoperatively, repair of the invagination could not be accomplished easily; therefore, the repair was abandoned. Instead, the tumor was removed en bloc to avoid dissemination of the cancer. Histopathologically, the tumor was diagnosed as a poorly differentiated adenocarcinoma, pStage. A. The patient has no evidence of recurrence at 10 mo after the operation. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

DOI： 10.3748/wjg.v20.i35.12678

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Colitic cancerおよびhigh grade dysplasiaを合併した潰瘍性大腸炎の臨床病理学的特徴

稲田涼, 近藤喜太, 母里淑子, 岸本浩行, 永坂岳司, 平岡佐規子, 藤原俊義

日本消化器病学会雑誌 111 ( 臨増大会 ) A889 - A889 2014.9

外科専門教育における献体を使用した臨床応用解剖実習および多視点多層解剖映像の有用性

近藤喜太, 信岡大輔, 黒田新士, 前田直見, 藤原俊義, 大塚愛二

医学教育 45 ( Suppl. ) 158 - 158 2014.7

局所進行直腸癌に対する術前放射線化学療法CapeOx RTの有効性・安全性の検討

母里淑子, 永坂岳司, 稲田涼, 岸本浩行, 近藤喜太, 藤智和, 谷口崇文, 浅野博昭, 佃和憲, 藤原俊義

日本消化器外科学会総会 69回 O - 4 2014.7

消化器癌に対する個別化治療 Genetic/epigenetic変異を基盤とした大腸癌個別化治療の構築

永坂岳司, 母里淑子, 稲田涼, 岸本浩行, 近藤喜太, 浅野博昭, 佃和憲, 西崎正彦, 香川俊輔, 藤原俊義

日本消化器外科学会総会 69回 SY - 8 2014.7

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Papers - KONDOU Yoshitaka