Faculty Profiles - KONDOU Yoshitaka

Papers - KONDOU Yoshitaka

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肺癌と直腸癌の同時性重複癌にpembrolizumabが著効した1例

岡凌也, 寺石文則, 杉本龍馬, 武田正, 垣内慶彦, 高田暢夫, 重安邦俊, 菊地覚次, 矢野修也, 近藤喜太, 黒田新士, 香川俊輔, 藤原俊義

日本臨床外科学会雑誌 81 ( 6 ) 1202 - 1203 2020.6

術前SOX療法を施行した進行胃癌症例の治療成績(Outcomes of preoperative S-1 plus oxaliplatin(SOX) therapy for advanced gastric cancer)

香川俊輔, 黒田新士, 菊地覚次, 高田暢夫, 垣内慶彦, 武田正, 野間和広, 田辺俊介, 寺石文則, 近藤喜太, 矢野修也, 重安邦俊, 西崎正彦, 白川靖博, 藤原俊義

日本胃癌学会総会記事 92回 288 - 288 2020.3

術前SOX療法を施行した進行胃癌症例の治療成績(Outcomes of preoperative S-1 plus oxaliplatin(SOX) therapy for advanced gastric cancer)

日本胃癌学会総会記事 92回 288 - 288 2020.3

肺癌と直腸癌の同時性重複癌にpembrolizumabが著効した1例 Reviewed

岡凌也, 寺石文則, 重安邦俊, 母里淑子, 近藤喜太, 藤原俊義

外科 82 ( 2 ) 186 - 190 2020.2

Language：Japanese Publisher：(株)南江堂

74歳男性。血痰と黒色便を主訴に近医を受診、CTにて左肺癌と下部直腸癌が疑われ、当院へ紹介となった。胸部造影CTおよび下部消化管内視鏡、気管支擦過細胞診より、肺腺癌(cStage IV A)と直腸癌(cStage IIIb)の同時性重複癌と診断され、pembrolizumabの投与が行なわれた。12コース終了時点でのCTでは肺癌の原発巣およびリンパ節転移は著明に縮小し、直腸内視鏡検査でも直腸癌の縮小が確認された。そこで、肺癌は画像上CR(complete response)で予後が見込めるとし、直腸癌に対しての根治術として腹腔鏡下Miles手術、上方D3リンパ節郭清、横行結腸人工肛門閉鎖後にS状結腸人工肛門造設術が行なわれた。その結果、術後の経過は良好で、術後7日目に退院となった。尚、術後1ヵ月よりpembrolizumabの投与を再開・継続中であるが、重篤な有害事象は認めず、直腸癌の再発も認められていない。

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Other Link： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J00393&link_issn=&doc_id=20200130110017&doc_link_id=issn%3D0016-593X%26volume%3D82%26issue%3D2%26spage%3D186&url=http%3A%2F%2Fwww.pieronline.jp%2Fopenurl%3Fissn%3D0016-593X%26volume%3D82%26issue%3D2%26spage%3D186&type=PierOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00005_2.gif

直腸癌腹腔鏡手術における縫合不全と回腸人工肛門合併症の因果関係についての検討 Reviewed

重安邦俊, 母里淑子, 矢野修也, 近藤喜太, 寺石文則, 香川俊輔, 藤原俊義

日本内視鏡外科学会雑誌 24 ( 7 ) SF055 - 6 2019.12

【これ一冊でわかる炎症性腸疾患診療のすべて】炎症性腸疾患のバイオマーカー

平岡佐規子, 安富絵里子, 岡昌平, 山崎泰史, 井口俊博, 高原政宏, 衣笠秀明, 原田馨太, 近藤喜太, 加藤順, 岡田裕之

消化器外科 42 ( 12 ) 1653 - 1662 2019.11

周術期管理チーム介入によるリスク評価が高齢者大腸癌患者の術後アウトカムに与える影響

寺石文則, 重安邦俊, 矢野修也, 母里淑子, 近藤喜太, 藤原俊義

日本消化器外科学会雑誌 52 ( Suppl.2 ) 253 - 253 2019.11

潰瘍性大腸炎に併発したNeuroendocrine carcinomaの1例 Reviewed

俣野貴慶, 高橋一剛, 近藤喜太, 重安邦俊, 藤原俊義

日本臨床外科学会雑誌 80 ( 増刊 ) 874 - 874 2019.10

A Granulation Polyp in the Colon Masquerading as Metastatic Cancer. Reviewed

Iwamuro M, Takahara M, Yamazaki T, Tanaka T, Kondo Y, Hiraoka S, Okada H

Acta medica Okayama 73 ( 5 ) 457 - 461 2019.10

Language：English

A 60-year-old Caucasian male was diagnosed with lung adenocarcinoma and multiple metastases to the bone, spleen, and brain. He underwent radiotherapy for the brain and lumbar spine metastases, plus chemotherapy (cisplatin and pemetrexed). The chemotherapy was discontinued due to vomiting and hyponatremia, and nivolumab was then administered. Eight months later, 18F-fluorodeoxyglucose positron emission tomography showed tracer uptake in the colon. Colonoscopy revealed a reddish multinodular polyp in the sigmoid colon. The polyp showed irregular microvessels. No colonic mucosal surface structures were observed. Colonic metastasis of the lung carcinoma was highly suspected; the polyp was therefore surgically removed. The histological analysis revealed granulation tissue and suppurative inflammation without neoplastic changes. We diagnosed the lesion as a granulation polyp. Despite the difficulty in diagnosing these lesions due to their rarity and similarity to metastatic colon tumors, we suggest that recognizing the endoscopic features of the polyp surface may allow a preoperative diagnosis.

DOI： 10.18926/AMO/57377

PubMed

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AZIN1 RNA編集は大腸癌微小環境の再構成を促進し癌の進展に寄与する新たなメカニズムである(AZIN1 RNA editing is a novel mechanism that enhances malignant potential of colorectal cancer microenvironment) Reviewed

武田正, 重安邦俊, 吉田一博, 母里淑子, 矢野修也, 近藤喜太, 野間和広, 寺石文則, 楳田祐三, 岸本浩行, 田澤大, 香川俊輔, 藤原俊義

日本癌学会総会記事 78回 E - 2079 2019.9

【大腸】ストーマ造設法と閉鎖法の工夫回腸双孔式人工肛門の2大合併症である閉塞とhigh output stomaのリスク因子同定と回避のための工夫 Reviewed

重安邦俊, 矢野修也, 母里淑子, 近藤喜太, 岸本浩行, 寺石文則, 香川俊輔, 白川靖博, 藤原俊義

日本消化器外科学会総会 74回 WS10 - 6 2019.7

Anterior Cutaneous Nerve Entrapment Syndrome Possibly Triggered by Oral Contraceptives.

Daisuke Omura, Mikako Obika, Masaya Iwamuro, Satoko Nagao, Takahiro Nada, Takashi Matsuzaki, Yoshitaka Kondo, Fumio Otsuka

Internal medicine (Tokyo, Japan) 58 ( 10 ) 1507 - 1509 2019.5

Language：English Publishing type：Research paper (scientific journal)

We herein report a teenage girl who had been taking oral contraceptive pills for three months and complained of left lower abdominal pain that had continued for two months. A physical examination indicated anterior cutaneous nerve entrapment syndrome (ACNES), although no abnormality was found in various biochemical and imaging examinations. The pain was only transiently ameliorated by trigger-point injection, and neurectomy surgery was eventually effective. Sex steroids can be involved in the progress of local tissue edema causing ACNES. ACNES should be considered in cases of abdominal pain in patients taking oral contraceptives.

DOI： 10.2169/internalmedicine.1361-18

PubMed

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中毒性巨大結腸症を合併していた重症潰瘍性大腸炎の一例

岡昌平, 高原政宏, 平岡佐規子, 安富絵里子, 井口俊博, 平井麻美, 山崎泰史, 杉原雄策, 衣笠秀明, 原田馨太, 高橋一剛, 近藤喜太, 岡田裕之

日本消化器病学会中国支部例会プログラム・抄録集 111回 87 - 87 2019.5

潰瘍性大腸炎に合併したMixed Neuroendocrine-Non-Neuroendocrine Neoplasmsの一例

永原崇甫, 衣笠秀明, 岡昌平, 安富絵里子, 平井麻美, 山本俊平, 山崎泰史, 井口俊博, 杉原雄策, 高原政宏, 原田馨太, 平岡佐規子, 近藤喜太, 田中健大, 岡田裕之

日本消化器病学会中国支部例会プログラム・抄録集 111回 72 - 72 2019.5

Activation of AZIN1 RNA editing is a novel mechanism that promotes invasive potential of cancer-associated fibroblasts in colorectal cancer. Reviewed International journal

Sho Takeda, Kunitoshi Shigeyasu, Yoshinaga Okugawa, Kazuhiro Yoshida, Yoshiko Mori, Shuya Yano, Kazuhiro Noma, Yuzo Umeda, Yoshitaka Kondo, Hiroyuki Kishimoto, Fuminori Teraishi, Takeshi Nagasaka, Hiroshi Tazawa, Shunsuke Kagawa, Toshiyoshi Fujiwara, Ajay Goel

Cancer letters 444 127 - 135 2019.3

Language：English Publishing type：Research paper (scientific journal)

Adenosine-to-inosine (A-to-I) RNA editing is a recently described epigenetic modification, which is believed to constitute a key oncogenic mechanism in human cancers. However, its functional role in cancer-associated fibroblasts (CAFs) within the tumor microenvironment (TME) and its clinical significance remains unclear. Herein, we systematically analyzed a large cohort of 627 colorectal cancer (CRC) specimens, and investigated the expression pattern of ADAR1 and its biological significance on the antizyme inhibitor 1 (AZIN1) RNA editing levels. Both ADAR1 expression and AZIN1 RNA editing levels were significantly elevated in CRC tissues vs. normal mucosa, and these findings correlated with the increased expression of mesenchymal markers, Vimentin (ρ = 0.44) and Fibroblast activation protein (ρ = 0.38). Intriguingly, ADAR1 expression was specifically upregulated in both cancer cells and fibroblasts from cancerous lesions. Conditioned medium from cancer cells led to induction of ADAR1 expression and activation of AZIN1 RNA editing in fibroblasts (p < 0.05). Additionally, edited AZIN1 enhanced the invasive potential of fibroblasts. In conclusion, we provide novel evidence that hyper-editing of AZIN1 enhances the invasive potential of CAFs within the TME in colon and is an important predictor of tumor invasiveness in CRC.

DOI： 10.1016/j.canlet.2018.12.009

PubMed

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多発筋炎/皮膚筋炎でみつかった直腸癌の一例 Reviewed

重安邦俊, 母里淑子, 三村直毅, 小松泰浩, 戸嶋俊明, 矢野修也, 近藤喜太, 岸本浩行, 寺石文則, 香川俊輔, 藤原俊義

日本臨床外科学会雑誌 80 ( 3 ) 607 - 607 2019.3