研究者詳細 - 髙原　政宏

論文 - 髙原　政宏

分割表示 161 件中 41 - 60 件目／全件表示 >>

Transabdominal ultrasound sonography findings in peritonitis due to the spread of Crohn's disease to the penetration 査読国際誌

Masahiro Takahara, Sakiko Hiraoko, Hiroyuki Okada

Clinical Case Reports 8 ( 12 ) 3561 - 3562 2020年12月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Blackwell Publishing Ltd

In the presence of the clinical signs of peritonitis, transabdominal ultrasound sonography by experienced technicians or physicians could be a fast and reliable imaging tool for confirmation of disease status.

DOI： 10.1002/ccr3.3215

Scopus

PubMed

researchmap

Evaluation of complete cold forceps polypectomy resection rate for 3- to 5-mm colorectal polyps. 査読国際誌

Yasushi Yamasaki, Keita Harada, Shumpei Yamamoto, Eriko Yasutomi, Mami Hirai, Masayasu Ohmori, Shohei Oka, Toshihiro Inokuchi, Hideaki Kinugasa, Yuusaku Sugihara, Masahiro Takahara, Sakiko Hiraoka, Takehiro Tanaka, Toshiharu Mitsuhashi, Hiroyuki Okada

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 33 ( 6 ) 948 - 954 2020年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND AND STUDY AIMS: The propriety of cold forceps polypectomy (CFP) using jumbo biopsy forceps for diminutive polyps remains controversial. We conducted a prospective study to evaluate the complete CFP resection rate of 3-5-mm polyps using additional endoscopic mucosal resection (EMR) specimens following CFP. PATIENTS AND METHODS: Patients with 3-5-mm protruded or flat elevated colorectal polyps diagnosed endoscopically as adenomas or serrated lesions were prospectively enrolled. CFP using jumbo biopsy forceps was used to remove the eligible polyps and repeated until the absence of residuals were confirmed via image-enhanced endoscopy or chromoendoscopy. After CFP, saline was injected at the defect, and the marginal specimen of the defect was resected using EMR to histologically evaluate the residue. The primary outcome was the complete CFP resection rate, which was defined as no residue at the EMR site. Other outcomes were the number of CFP bites and the complete resection rate by lesion size. RESULTS: Eighty patients with 120 polyps were enrolled. The mean polyp size was 4.1 ± 0.7 mm. The overall complete resection rate was 96.7% (95% confidence interval [CI], 91.7-98.7), and the rates for 3-, 4- and 5-mm polyps were 100% (95% CI, 86.7-100), 96.0% (95% CI, 86.5-98.9) and 95.5% (95% CI, 85.1-98.8), respectively. The one-bite CFP rates were 92%, 60% and 31% for the 3-, 4- and 5-mm polyps, respectively. CONCLUSIONS: The complete CFP resection rate for 3-5-mm polyps was acceptable, although the one-bite clearance rate decreased as the polyp size increased (UMIN000028841).

DOI： 10.1111/den.13895

PubMed

researchmap

潰瘍性大腸炎における経腹超音波検査の有用性

高原政宏, 平岡佐規子, 大森正泰, 安富絵里子, 岡昌平, 平井麻美, 井口俊博, 山本峻平, 山崎泰史, 衣笠秀明, 原田馨太, 大西秀爾, 岡田裕之

日本消化器病学会雑誌 117 ( 臨増大会 ) A706 - A706 2020年10月

潰瘍性大腸炎における経腹超音波検査の有用性

高原政宏, 平岡佐規子, 大森正泰, 安富絵里子, 岡昌平, 平井麻美, 井口俊博, 山本峻平, 山崎泰史, 衣笠秀明, 原田馨太, 大西秀爾, 岡田裕之

日本消化器病学会雑誌 117 ( 臨増大会 ) A706 - A706 2020年10月

Multiple Deep-seated Dentofacial Abscesses Caused by Multidrug-resistant Viridans Group Streptococci. 査読

Shinnosuke Fukushima, Hideharu Hagiya, Yuki Mizuta, Yasuhiro Nakano, Masahiro Takahara, Kayo Okamoto, Yuko Hayashi, Kiyoshi Yamada, Kou Hasegawa, Fumio Otsuka

Internal medicine (Tokyo, Japan) 59 ( 16 ) 2067 - 2070 2020年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

Odontogenic infections, generally caused by dental caries and periodontal disease, can result in fatal illness. We herein report a 71-year-old Japanese woman with type 2 diabetes and hemodialysis who suffered from multiple dentofacial abscesses mainly caused by multidrug-resistant Streptococcus oralis. She complained of pain and swelling of her face, with an extraoral fistula from the left cheek. Following 3 surgical debridement procedures and partial mandibulectomy, in addition to 12 weeks of antimicrobial therapy, the multiple dentofacial abscesses were ameliorated. A combination of surgical and antimicrobial treatments following an early diagnosis is essential for reducing further complications.

DOI： 10.2169/internalmedicine.4283-20

PubMed

researchmap

Factors Predicting a Favorable Disease Course Without Anti-TNF Therapy in Crohn's Disease Patients. 査読

Toshihiro Inokuchi, Sakiko Hiraoka, Eriko Yasutomi, Shohei Oka, Yasushi Yamasaki, Hideaki Kinugasa, Masahiro Takahara, Seiji Kawano, Keita Harada, Hiroyuki Okada, Jun Kato

Acta medica Okayama 74 ( 4 ) 265 - 274 2020年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

Determining factors that predict a favorable disease course without anti-tumor necrosis factor (TNF) agents would help establish a more cost-effective strategy for Crohn's disease (CD). A retrospective chart review was performed for CD patients with disease durations > 10 years who had not received anti-TNF agents as first-line therapy. Patients were divided into 2 groups: those who received neither anti-TNF agents nor bowel resection (G1), and those who had received an anti-TNF agent and/or bowel resection (G2). The patient backgrounds, therapies and clinical courses were compared between the groups. A total of 62 CD patients met the inclusion criteria (males: 71%; median duration of follow-up: 19 years). Six patients were included in G1; they were significantly less likely to have upper gastrointestinal lesions than G2 (p=0.007). A multivariate analysis revealed that the significant factors for avoidance of bowel resection without anti-TNF treatment were non-stricturing and non-penetrating behaviors, and absence of upper gastrointestinal lesions at the diagnosis (hazard ratios 0.41 and 0.52; p=0.004 and 0.04, respectively). In consideration of the long treatment course of CD, patients with non-stricturing and non-penetrating behaviors and no upper gastrointestinal lesions should not be treated with anti-TNF agents as first-line therapy.

DOI： 10.18926/AMO/60363

PubMed

researchmap

【分子標的時代のIBD診療-IBDの寛解導入,寛解維持の実践】IBD治療における寛解導入と寛解維持に関するトピック IBD寛解維持期における便中マーカーによるモニタリング

平岡佐規子, 安富絵里子, 岡昌平, 井口俊博, 高原政宏, 岡田裕之

臨床消化器内科 35 ( 10 ) 1256 - 1262 2020年8月

記述言語：日本語出版者・発行元：(株)日本メディカルセンター

＜文献概要＞炎症性腸疾患(IBD)診療における治療の選択肢は年々増えており,多くの患者に速やかな寛解導入,長期の寛解維持が望めるようになってきた.しかし,いったん寛解となっても再燃する場合はあり,その場合にはいかに早期に治療介入できるかが,重要となってくる.再燃を早期に発見するためには,臨床症状の確認とともに,粘膜治癒と相関し,かつ,非侵襲性で繰り返し測定可能なバイオマーカーをうまく利用することが重要である.バイオマーカーの有力な候補として,便中マーカーである便中カルプロテクチン,免疫学的便潜血法がある.臨床的寛解であっても継続的にそれら測定値の上昇を認めた場合は,再燃の可能性を考える必要がある.

researchmap

当院における早期胃癌ESD非治癒切除症例の検討

山本高史, 竹中龍太, 矢杉賢吾, 平田翔一郎, 小幡泰介, 倉岡紗樹子, 平井伸典, 高原政宏, 河合大介, 堀圭介, 柘野浩史, 藤木茂篤

Gastroenterological Endoscopy 62 ( Suppl.1 ) 1249 - 1249 2020年8月

ベルベリンによる慢性腸炎マウスの腸内細菌叢の変化

高原政宏, 高木章乃夫, 平岡佐規子, 安富絵里子, 山本峻平, 岡昌平, 平井麻美, 山崎泰史, 井口俊博, 衣笠秀明, 原田馨太, 岡田裕之

日本消化器病学会雑誌 117 ( 臨増総会 ) A275 - A275 2020年7月

【皆で診る!IBD:多職種連携と地域医療】患者中心の医療 shared decision making(SDM)とは? メンタルケアも含めて

井口俊博, 平岡佐規子, 安富絵里子, 岡昌平, 高原政宏, 岡田裕之

IBD Research 14 ( 2 ) 82 - 86 2020年6月

記述言語：日本語出版者・発行元：(株)先端医学社

shared decision making(SDM)は困難な課題に対して医療従事者と患者とのあいだでなされるべき「意思決定の共有」であり、同時に合意形成をおこなうための重要なコミュニケーションツールである。炎症性腸疾患(IBD)は不均一な患者群で構成されているだけでなく、近年、検査や薬剤の開発が進み、診療の選択肢の幅が急激に増加し複雑化しているため、その診療における選択肢は多岐にわたり、SDMの重要性はいっそう増している。SDMを用いて、エビデンスに基づいたデータを患者の希望や価値観に沿った形で提供することで、患者の疾患に対する理解度、満足度は高まり、より良いIBD診療につなげることが可能となる。(著者抄録)

researchmap

経皮肝腫瘍生検にて診断しえた末梢型T細胞リンパ腫の1例

大山淳史, 大西秀樹, 足立卓哉, 和田望, 高原政宏, 坂田雅浩, 安中哲也, 平岡佐規子, 丹羽知子, 戸田由香, 岡田裕之

日本消化器病学会中国支部例会プログラム・抄録集 113回 105 - 105 2020年5月

Observer agreement for the diagnosis of intestinal acute graft-vs.-host disease based on the presence of villous atrophy in the terminal ileum. 査読国際誌

Yuusaku Sugihara, Sakiko Hiraoka, Eriko Yasutomi, Shohei Oka, Yasushi Yamasaki, Toshihiro Inokuchi, Hideaki Kinugasa, Masahiro Takahara, Yuki Morito, Sakuma Takahashi, Keita Harada, Takehiro Tanaka, Fumio Otsuka, Hiroyuki Okada

Experimental and therapeutic medicine 19 ( 4 ) 3076 - 3080 2020年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

Intestinal graft-vs.-host disease (GVHD) is a serious complication of allo-hematopoietic stem cell transplantation (allo-HSCT). Villous atrophy in the terminal ileum is considered a useful diagnostic indicator for GVHD. However, the inter- and intra-observer agreement regarding the ileocolonoscopic findings indicative of acute intestinal GVHD, i.e., villous atrophy in the terminal ileum, are currently insufficient in multiple institutions. Thus, the present study aimed to investigate the incidence of villous atrophy in the terminal ileum to diagnose acute intestinal GVHD and determine the inter- and intra-observer agreement regarding this result for experienced endoscopists from multiple institutions. Consecutive patients who underwent allo-HSCT were referred to our institution between May 2008 and September 2015. A total of 54 patients underwent total ileocolonoscopy after allo-HSCT due to suspected intestinal acute GVHD. Subsequently, three observers from different institutions evaluated the cases for the presence of villous atrophy in the terminal ileum. In this study, the pathology results were a gold standard to evaluate the predictive value of ileocolonoscopy detection. Definitive pathological and non-pathological GVHD was diagnosed in 22 and 32 cases, respectively. The results of examining whether villous atrophy could predict GVHD were as follows. For three observers (A, B and C), the sensitivity of villous atrophy in the terminal ileum was 86.4, 77.3 and 79.2%, respectively, whereas the specificity was 62.5, 62.5 and 86.7%, respectively. The positive predictive value (PPV) and negative predictive value (NPV) of villous atrophy for GVHD were as follows: The PPV of appearance was 61.3, 58.6 and 82.6%, respectively, whereas the NPV was 87.0, 80.0 and 83.9%, respectively. Kappa coefficients for the inter-observer reliability were 0.85, 0.63 and 0.63 for observers A and B, A and C, and B and C, respectively. The intra-observer kappa coefficient was 0.88 for observer A, 0.73 for observer B and 0.75 for observer C. A substantial observer agreement was achieved for the analysis of villous atrophy in the terminal ileum and the agreement for the predictive histological diagnosis was also excellent. Based on the results of the present study, identification of villous atrophy in the terminal ileum was a clinically effective diagnostic parameter, even if different endoscopists were involved in the diagnosis at multiple institutions. The present study was registered as a trial with the University Hospital Medical Information Network (UMIN; registration no. UMIN000025390).

DOI： 10.3892/etm.2020.8538

PubMed

researchmap

潰瘍性大腸炎における経腹超音波検査の有用性

高原政宏, 平岡佐規子, 安富絵里子, 岡昌平, 平井麻美, 井口俊博, 竹中龍太, 藤木茂篤, 岡田裕之

日本内科学会雑誌 109 ( Suppl. ) 188 - 188 2020年2月

レーザー内視鏡診療の現状と近未来浸水下での大腸ポリープ境界診断におけるBLI/LCIの有効性を評価するための後ろ向き観察研究

山崎泰史, 原田馨太, 安富絵里子, 山本峻平, 岡昌平, 平井麻美, 井口俊博, 衣笠秀明, 高原政宏, 平岡佐規子, 岡田裕之

日本消化管学会雑誌 4 ( Suppl. ) 223 - 223 2020年1月

倦怠感で発症し急速な経過で下垂体不全を来した視床下部原発悪性リンパ腫の1例

高瀬了輔, 中野靖浩, 水田有紀, 安田美帆, 長谷川功, 高原政宏, 萩谷英大, 大塚文男

日本内分泌学会雑誌 95 ( 3 ) 1173 - 1173 2020年1月

Switching between Three Types of Mesalazine Formulation and Sulfasalazine in Patients with Active Ulcerative Colitis Who Have Already Received High-Dose Treatment with These Agents. 査読国際誌

Yasutomi E, Hiraoka S, Yamamoto S, Oka S, Hirai M, Yamasaki Y, Inokuchi T, Kinugasa H, Takahara M, Harada K, Kato J, Okada H

Journal of clinical medicine 8 ( 12 ) 2019年12月

膵癌におけるFNA検体と切除検体とのPD-L1発現の検討

松本和幸, 高木章乃夫, 大原利章, 藤澤真義, 高原政宏, 加藤博也, 吉田龍一, 楳田祐三, 八木孝仁, 松川昭博, 岡田裕之

日本消化器病学会雑誌 116 ( 臨増大会 ) A826 - A826 2019年11月

【これ一冊でわかる炎症性腸疾患診療のすべて】炎症性腸疾患のバイオマーカー

平岡佐規子, 安富絵里子, 岡昌平, 山崎泰史, 井口俊博, 高原政宏, 衣笠秀明, 原田馨太, 近藤喜太, 加藤順, 岡田裕之

消化器外科 42 ( 12 ) 1653 - 1662 2019年11月

リンパ節の再生検からHodgkinリンパ腫の診断に至った不明熱の1例

荒木晴, 徳増一樹, 原田洸, 山本晃, 高原政宏, 長谷川功, 萩谷英大, 花山宜久, 大塚文男

日本病院総合診療医学会雑誌 15 ( 6 ) 602 - 602 2019年11月

直腸顆粒細胞腫(Granular Cell Tumor)の1例

深田悠史, 衣笠秀明, 山本俊平, 平井麻美, 安富絵里子, 岡昌平, 山崎泰史, 井口俊博, 高原政宏, 原田馨太, 平岡佐規子, 田中健大, 岡田裕之

日本消化器病学会中国支部例会プログラム・抄録集 112回 146 - 146 2019年11月

　前のページ - 次のページ　

<髙原 政宏>

論文 - 髙原 政宏

<髙原　政宏>

論文 - 髙原　政宏