研究者詳細 - 渡邊　彰吾

論文 - 渡邊　彰吾

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Low plasma apolipoprotein E-rich high-density lipoprotein levels in patients with metabolic syndrome 査読

Ryoko Shinohata,Yuhei Shiga,Shin-Ichiro Miura,Satoshi Hirohata,Misako Shibakura,Tomoe Ueno-Iio,Shogo Watanabe,Yujiro Arao,Shinichi Usui

Clinica Chimica Acta 510 531 - 536 2020年8月

Bile acids aggravate nonalcoholic steatohepatitis and cardiovascular disease in SHRSP5/Dmcr rat model 査読国際誌

Experimental and Molecular Pathology 114 104437 - 104437 2020年6月

Bile acid metabolism is an intermediary factor between non-alcoholic steatohepatitis and ischemic heart disease in SHRSP5/Dmcr rats 査読

Journal of Nutrition and Food Sciences 09 ( 04 ) 2019年10月

Non-alcoholic steatohepatitis aggravates nitric oxide synthase inhibition-induced arteriosclerosis in SHRSP5/Dmcr rat model 査読

Shogo Watanabe, Shota Kumazaki, Shusei Yamamoto, Ikumi Sato, Kazuya Kitamori, Mari Mori, Yukio Yamori, Satoshi Hirohata

International Journal of Experimental Pathology 2019年1月

Non-alcoholic steatohepatitis aggravates nitric oxide synthase inhibition-induced arteriosclerosis in SHRSP5/Dmcr rat model. 査読国際誌

Shogo Watanabe, Shota Kumazaki, Shusei Yamamoto, Ikumi Sato, Kazuya Kitamori, Mari Mori, Yukio Yamori, Satoshi Hirohata

International journal of experimental pathology 99 ( 6 ) 282 - 294 2018年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

Non-alcoholic steatohepatitis (NASH) is linked to increased cardiovascular risk, independent of the broad spectrum of metabolic syndrome risk factors. Stroke-prone (SP) spontaneously hypertensive rats (SHRSP5/Dmcr) fed a high-fat and high-cholesterol (HFC) diet developed hepatic lesions similar to those in human NASH pathology. These rats simultaneously developed lipid deposits in the mesenteric arteries, cardiac fibrosis, endothelial dysfunction and left ventricle (LV) diastolic dysfunction. However, the intermediary factors between NASH and cardiovascular disease are still unknown. We investigated whether NASH aggravates nitric oxide (NO) synthase inhibition-induced arteriosclerosis in SHRSP5/Dmcr rats. Wistar Kyoto and SHRSP5/Dmcr rats were divided into 4 groups of 5 and fed the stroke-prone (SP) or HFC diets for 8 weeks. To induce NO synthase inhibition, Nω -nitro-L-arginine methyl ester hydrochloride (L-NAME) mixed with drinking water was administered in the final 2 weeks. The NASH+L-NAME group demonstrated the following characteristics related to arteriosclerosis and myocardial ischaemia: (a) LV systolic dysfunction with asynergy, (b) replacement fibrosis caused by the shedding of cardiomyocytes and (c) arterial lipid deposition and coronary occlusion secondary to endothelial dysfunction. These characteristics were not observed in the NASH or non-NASH+L-NAME groups. The SHRSP5/Dmcr rat model demonstrates that NASH significantly aggravates cardiovascular risk.

DOI： 10.1111/iep.12301

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Novel Mechanomyogram/electromyogram Hybrid Transducer Measurements Reflect Muscle Strength during Dynamic Exercise ̶ Pedaling of Recumbent Bicycle ̶ 査読

Shinichi Fukuhara, Shogo Watanabe, Hisao Oka

Advanced Biomedical Engineering 7 47 - 54 2018年

SHRSP5/Dmcrラットにおける循環器系の基礎病態解析査読

渡辺彰吾, 熊崎章太

SHR等疾患モデル共同研究会News letter 2018年

SHRSP5/Dmcr rat fed with high-fat and high-cholesterol diet induces cardiac fibrosis, vascular endothelial and left ventricular diastolic dysfunction 査読

Shogo Watanabe, Shota Kumazaki, Katsuhiro Kusunoki, Terumi Inoue, Yui Maeda, Shinichi Usui, Ryoko Shinohata, Takashi Ohtsuki, Satoshi Hirohata, Shozo Kusachi, Kazuya Kitamori, Mari Mori, Yukio Yamori, and Hisao Oka

Journal of Atherosclerosis and Thrombosis 25 ( 5 ) 439 - 453 2018年

Estimating the minimum stimulation frequency necessary to evoke tetanic progression based on muscle twitch parameters 査読

Shogo Watanabe, Shinichi Fukuhara, Takeshi Fujinaga and Hisao Oka

Physiological Measurement 38 ( 3 ) 466 - 476 2017年3月

The developed MMG / EMG Hybrid Transducer reflects Muscle Strength during Dynamic Exercise - Pedaling of Recumbent Bicycle - 査読

Shinichi Fukuhara, Shogo Watanabe, Hisao Oka

Advanced Biomedical Engineering 7 47 - 54 2017年

5チャンネル同時計測型MMG/EMGハイブリッドセンサシステムの開発査読

福原真一, 渡辺彰吾, 岡久雄

生体医工学 55 ( 4 ) 252 - 252 2017年

記述言語：日本語出版者・発行元：公益社団法人日本生体医工学会

<p>筋音図（Mechanomyoram : MMG）と筋電図（Electromyogram : EMG）を同時計測することにより、骨格筋収縮の正確な評価が可能となる。しかし、筋音図は身体を固定して計測しなければならない等の理由からこれまで用いられることが少なかった。そこで筆者らは、筋音図と筋電図の同時計測が可能なMMG/EMGハイブリッドセンサシステムを開発した。デバイス本体は小型軽量（47×34×24mm、34g）であり、簡便に皮膚に貼付できる。ハイブリッドセンサは、筋音／筋電センサ部、トランスデューサ部およびストレージ（SDカード）が一体となっていることから、付属装置を必要とせずに筋音／筋電計測を行うことができる。従来、センサの固定に微妙な調節が必要であったが、センサ形状に合わせた専用のベルトを用いることにより、簡単に取り付けが可能となった。また、センサと操作端末はBluetooth(R)を介して通信され、計測・制御ソフトウェアによって最大5台のハイブリッドセンサを一括制御でき、サンプリング時間や測定時間等の計測パラメータが設定できる。筋音／筋電波形はリアルタイムモニタリングされ，データはCSV形式で出力される。MMG/EMGハイブリッドセンサシステムの開発により、適用フィールドを問わず、誰もが容易に筋音／筋電計測を行えるようになった。謝辞本研究の一部は、H28年度特別電源所在県科学技術振興事業（岡山県）の助成を受けた。記して謝意を表する。</p>

DOI： 10.11239/jsmbe.55Annual.252

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Electrically induced mechanomyograms reflect inspiratory muscle strength in young or elderly subjects 査読

Shogo Watanabe, Ippei Nojima, Yuuna Agarie, Tatsunori Watanabe, Shinichi Fukuhara, Takeshi Fujinaga, Hisao Oka

Respiratory Investigation 54 ( 6 ) 436 - 444 2016年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Elsevier B.V.

Background Respiratory muscle strength has been used as a tool for evaluating respiratory rehabilitation in chronic obstructive pulmonary disease. However, mouth pressure measurement evaluated by maximum expiratory mouth pressure (PEmax) or inspiratory mouth pressure (PImax) offers an indirect method for measuring respiratory muscle strength. We demonstrated the evaluation of diaphragm contractility using a mechanomyogram (MMG), which is the mechanical signal generated by the motion of the diaphragm induced by the electric stimulation of the phrenic nerve. Methods Study participants were 21 young and 20 elderly subjects with no symptoms of respiratory disease. The elderly subjects were divided into non-smoker or smoker groups. The smoker group was defined as subjects having a Brinkman Index of greater than 300. We measured basic spirometric parameters, mouth pressure (PEmax, PImax), and diaphragmatic MMG. Results Diaphragmatic MMG showed more clear contrast between young subjects and elderly non-smoker or smoker subjects than the conventional method for respiratory muscle contraction (PEmax, PImax). In addition, the diaphragmatic MMG strongly correlated with inspiratory muscle strength. Conclusions Diaphragmatic MMG may reflect diaphragmatic contractility more directly and sensitively than the conventional method.

DOI： 10.1016/j.resinv.2016.06.001

Scopus

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Enhancement of arterial pulsation during flow-mediated dilation is impaired in the presence of ischemic heart disease 査読

Eisuke Amiya,Masafumi Watanabe,Shogo Watanabe*,Munenori Takata,Issei Komuro

SpringerPlus 5 ( 1 ) 2016年7月

Enhancement of arterial pulsation during flow-mediated dilation is impaired in the presence of ischemic heart disease 査読

Eisuke Amiya,Masafumi Watanabe,Shogo Watanabe*,Munenori Takata,Issei Komuro

SpringerPlus 5 ( 1103 ) 2016年7月

横隔膜筋音図と呼吸筋力の関係査読

渡辺彰吾, 福原真一, 藤長武士, 岡久雄

電子情報通信学会技術研究報告 116 ( 170 ) 25 - 28 2016年7月

Evaluation of skeletal muscle contraction during pedaling of recumbent bicycle using MMG/EMG hybrid transducer 査読

Shinichi Fukuhara, Takeshi Fujinaga, Shogo Watanabe, Hisao Oka

BME = Bio medical engineering / henshu, Nihon ME Gakkai, Japanese Journal of Medical Electronics and Biological Engineering, Transactions of Japanese Society for Medical and Biological Engineering, BME = Bio medical engineering / henshu, Nihon ME Gakkai 54 ( PROC ) 1 - 2 2016年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本生体医工学会

<p>Electromyogram (EMG) is recorded electrical muscle contraction, mechanomyogram (MMG) indicates cross-sectional area change of muscle, reflect mechanical muscle contraction. By simultaneously measuring both signals, it is possible to multifaceted evaluation of muscle contraction. However, MMG measurement at voluntary movement was difficult. Therefore, the authors developed MMG / EMG hybrid transducer capable of simultaneous measurement of MMG and EMG. This study evaluated MMG and EMG of rectus femoris (RF) and hamstrings using recumbent bicycle of easy load regulation. As result, dMMGbase (baseline of displacement MMG) indicated cross-sectional area change of muscle at pushing down and pulling up of pedal. In addition, EMG and dMMGbase increased with pushing down of pedal in RF, dMMGacc (acceleration dMMGbase) showing muscle contraction force was output simultaneously. Each signal of hamstrings had output that antagonize RF. By simultaneously measuring MMG and EMG at recumbent bicycle pedaling, it was possible to evaluate muscle contraction of voluntary movement.</p>

DOI： 10.11239/jsmbe.54Annual.P2-C04-1

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Blockade of glucocorticoid receptors with RU486 attenuates cardiac damage and adipose tissue inflammation in a rat model of metabolic syndrome 査読

Takeshita Y, Watanabe S, Hattori T, Nagasawa K, Matsuura N, Takahashi K, Murohara T, Nagata K

Hypertens Res 38 ( 11 ) 741 - 750 2015年11月

Restraint stress exacerbates cardiac and adipose tissue pathology via β-adrenergic signaling in rats with metabolic syndrome 査読

Matsuura N, Nagasawa K, Minagawa Y, Ito S, Sano Y, Yamada Y, Hattori T, Watanabe S, Murohara T, Nagata K

American Journal of Physiology-Heart and Circulatory Physiology 308 ( 10 ) H1275 - H1286 2015年5月

Roles of oxidative stress and the mineralocorticoid receptor in cardiac pathology in a rat model of metabolic syndrome 査読

Takahashi K, Murase T, Takatsu M, Matsuura N, Nagasawa K, Hattori T, Watanabe S, Murohara T, Nagata K

Nagoya Journal of Medical Science 77 ( 1-2 ) 275 - 289 2015年2月

Comparative effects of valsartan in combination with cilnidipine or amlodipine on cardiac remodeling and diastolic dysfunction in Dahl salt-sensitive rats 査読

Kai Nagasawa, Keiji Takahashi, Natsumi Matsuura, Miwa Takatsu, Takuya Hattori, Shogo Watanabe, Eri Harada, Kazumi Niinuma, Toyoaki Murohara, Kohzo Nagata

HYPERTENSION RESEARCH 38 ( 1 ) 39 - 47 2015年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：NATURE PUBLISHING GROUP

Angiotensin receptor blockers (ARBs) are often supplemented with calcium channel blockers (CCBs) for treatment of hypertension. We recently showed that the L/N-type CCB cilnidipine has superior cardioprotective effects compared with the L-type CCB amlodipine in Dahl salt-sensitive (DS) rats. We have now compared the effects of the ARB valsartan combined with cilnidipine or amlodipine on cardiac pathophysiology in DS rats. DS rats fed a high-salt diet from 6 weeks of age were treated with vehicle, valsartan alone (10 mg kg(-1) per day), or valsartan combined with either cilnidipine (1 mg kg(-1) per day) or amlodipine (1 mg kg(-1) per day) from 7 to 11 weeks. The salt-induced increase in systolic blood pressure apparent in the vehicle group was attenuated similarly in the three drug treatment groups. Valsartan-cilnidipine attenuated left ventricular (LV) fibrosis and diastolic dysfunction as well as cardiac oxidative stress and inflammation to a greater extent than did valsartan alone or valsartan-amlodipine. In addition, the increases in urinary excretion of dopamine and epinephrine as well as in cardiac renin-angiotensin-aldosterone-system (RAAS) gene expression apparent in vehicle-treated rats were attenuated to a greater extent by valsartan-cilnidipine than by the other two treatments. Valsartan-cilnidipine thus attenuated LV remodeling and diastolic dysfunction more effectively than did valsartan or valsartan-amlodipine in rats with salt-sensitive hypertension, and this superior cardioprotective action of valsartan-cilnidipine compared with valsartan-amlodipine is likely attributable, at least in part, to the greater antioxidant and antiinflammatory effects associated with both greater inhibition of cardiac RAAS gene expression and N-type calcium channel blockade.

DOI： 10.1038/hr.2014.136

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