研究者詳細 - 江口　傑徳

論文 - 江口　傑徳

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遺伝子発現の抑圧的調節を仲介するマウスctgf3'-UTR segmentの性質

近藤誠二, 久保田聡, 江口傑徳, 服部高子, 中西徹, 菅原利夫, 滝川正春

日本口腔科学会雑誌 50 ( 6 ) 568 - 568 2001年11月

Cell-type-specific trans-activation of herpes simplex virus thymidine kinase promoter by the human T-cell leukemia virus type I Tax protein. 査読

Kubota S, Mukudai Y, Hattori T, Eguchi T, Kondo S, Takigawa M

DNA and cell biology 20 ( 9 ) 563 - 568 2001年9月

多機能成長因子CTGF/Hcs24遺伝子の転写後制御エレメント,CAESARの作用機序

久保田聡, 近藤誠二, 椋代義樹, 江口傑徳, 服部高子, 中西徹, 滝川正春

生化学 73 ( 8 ) 710 - 710 2001年8月

Regulatory Mechanism of Human Connective Tissue Growth Factor (CTGF/Hcs24) Gene Expression in a Human Chondrocytic Cell Line, HCS-2/8 査読

T. Eguchi, S. Kubota, S. Kondo, T. Shimo, T. Hattori, T. Nakanishi, T. Kuboki, H. Yatani, M. Takigawa

Journal of Biochemistry 130 ( 1 ) 79 - 87 2001年7月

Novel mode of processing and secretion of connective tissue growth factor/ecogenin（CTGF/Hcs24） in chondrocytic HCS-2/8 cells 査読

Kubota S, Eguchi T, Shimo T, Nishida T, Hattori T, Kondo S, Nakanishi T, Takigawa M

Bone 29 ( 2 ) 155 - 161 2001年

遺伝子発現の抑制的な調節をもたらすマウスのctgf3′-UTRセグメントの特性

近藤誠二, 久保田聡, 江口傑徳, 服部高子, 中西徹, 菅原利夫, 滝川正春

日本口腔科学会雑誌 278 ( 1 ) 119 - 124 2000年11月

Characterization of a Mouse ctgf 3′-UTR Segment That Mediates Repressive Regulation of Gene Expression 査読

Seiji Kondo, Satoshi Kubota, Takanori Eguchi, Takako Hattori, Tohru Nakanishi, Toshio Sugahara, Masaharu Takigawa

Biochemical and Biophysical Research Communications 278 ( 1 ) 119 - 124 2000年11月

Identification of an RNA element that confers post-transcriptional repression of connective tissue growth factor/hypertrophic chondrocyte specific 24 (ctgf/hcs24) gene: Similarities to retroviral RNA-protein interactions 査読

S Kubota, S Kondo, T Eguchi, T Hattori, T Nakanishi, RJ Pomerantz, M Takigawa

ONCOGENE 19 ( 41 ) 4773 - 4786 2000年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：NATURE PUBLISHING GROUP

The repressive effect of the 3'-untranslated region (3'-UTR) in human connective tissue growth factor/hypertrophic chondrocyte specific 24 (ctgf/hcs24) mRNA on gene expression had been demonstrated in our previous study. Here, we identified a minimal RNA element in the 3'-UTR, which acts as a cis-acting element of structure-anchored repression (CAESAR). Deletion analyses of the 3'-UTR led us to minimize the element of 84 bases at the junction of the coding region and the 3'-UTR. The minimized RNA segment is predicted, and actually capable of forming a stable secondary structure in vitro. Mutational analyses disclosed a significant relationship between the predicted structure and repressive effect. The utility of CAESAR as a post-transcriptional regulatory element was represented by the fact that steady-state mRNA levels were not affected by CAESAR linked in cis, while protein levels from such a chimeric gene were markedly reduced. Of note, the CAESAR sequence exerted no effect, when it was placed upstream of the promoter. Finally, RNA gel electromobility-shift analyses demonstrated a nuclear factor that interacts with the folded CAESAR. Taken together, it was uncovered that CAESAR of ctgf is a novel post-transcriptional structured RNA regulatory element, probably acting through direct interactions with a nuclear factor as observed in retroviral RNA elements with certain proteins.

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軟骨由来の成長因子CTGF/Hcs24遺伝子の転写後制御エレメント,CAESARの構造機能連関

久保田聡, 近藤誠二, 江口傑徳, 服部高子, 中西徹, 滝川正春

生化学 72 ( 8 ) 972 - 972 2000年8月

軟骨細胞および線維芽細胞株におけるCTGF/Ecogenin遺伝子発現の3'-UTRによる調節

近藤誠二, 久保田聡, 江口傑徳, 服部高子, 中西徹, 菅原利夫, 滝川正春

岡山歯学会雑誌 19 ( 1 ) 205 - 206 2000年6月

軟骨由来の成長因子CTGF/Hcs24遺伝子に同定された新たな転写後制御エレメント,CAESAR

久保田聡, 近藤誠二, 江口傑徳, 服部高子, 中西徹, 滝川正春

日本骨代謝学会雑誌 18 ( 2 ) 119 - 119 2000年6月

アデノウイルスを用いた顎関節への遺伝子導入の試み

縄稚久美子, 窪木拓男, 完山学, 藤沢拓生, 園山亘, 江口傑徳, 上原淳二, 矢谷博文, 山下敦

日本補綴歯科学会雑誌 43 ( 102回特別 ) 180 - 180 1999年10月

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