研究者詳細 - 江口　傑徳

論文 - 江口　傑徳

分割表示 132 件中 61 - 80 件目／全件表示 >>

Regulatory Roles of HSP90-Rich Extracellular Vesicles

Takanori Eguchi, Kisho Ono, Kazumi Kawata, Kuniaki Okamoto, Stuart K. Calderwood

Heat Shock Proteins 3 - 17 2019年11月

A reporter system evaluates tumorigenesis, metastasis, β-catenin/MMP regulation, and druggability. 招待査読国際誌

Sogawa C, Eguchi T, C, i, auth, Corresponding author, Okusha Y, Ono K, Ohyama K, Iizuka M, Kawasaki R, Hamada Y, Takigawa M, Sogawa N, Okamoto K, Kozaki K

Tissue Engineering Part A 25 ( 19-20 ) 1413 - 1425 2019年10月

Tumor Angiogenic Inhibition Triggered Necrosis (TAITN) in Oral Cancer. 査読国際誌

Saori Yoshida, Hotaka Kawai, Takanori Eguchi, Shintaro Sukegawa, May Wathone Oo, Chang Anqi, Kiyofumi Takabatake, Keisuke Nakano, Kuniaki Okamoto, Hitoshi Nagatsuka

Cells 8 ( 7 ) 761 2019年7月

MZF1 and SCAND1 Reciprocally Regulate CDC37 Gene Expression in Prostate Cancer. 査読国際誌

Takanori Eguchi, Thomas L Prince, Manh Tien Tran, Chiharu Sogawa, Benjamin J Lang, Stuart K Calderwood

Cancers 11 ( 6 ) 792 2019年6月

Nicotine promotes lymph node metastasis and cetuximab resistance in head and neck squamous cell carcinoma. 査読国際誌

Rieko Shimizu, Soichiro Ibaragi, Takanori Eguchi, Daisuke Kuwajima, Shinichi Kodama, Takashi Nishioka, Tatsuo Okui, Kyoichi Obata, Kiyofumi Takabatake, Hotaka Kawai, Kisho Ono, Kuniaki Okamoto, Hitoshi Nagatsuka, Akira Sasaki

International journal of oncology 54 ( 1 ) 283 - 294 2019年1月

Carcinogenic epithelial-mesenchymal transition initiated by oral cancer exosomes is inhibited by anti-EGFR antibody cetuximab. 査読国際誌

Toshifumi Fujiwara, Takanori Eguchi, Chiharu Sogawa, Kisho Ono, Jun Murakami, Soichiro Ibaragi, Jun-Ichi Asaumi, Stuart K Calderwood, Kuniaki Okamoto, Ken-Ichi Kozaki

Oral oncology 86 251 - 257 2018年11月

Lipoprotein Cholesterols Are Stored in High-Resistant, Metastatic Cancer Cells and Released Upon Stress: Implication for a Mechanism Underlying Hypocholesterolemia in Cancer Patients

Taka Eguchi, Chiharu Sogawa, Kisho Ono, Mami Itagaki, Masaki Matsumoto

Preprints 2018年10月

担当区分：筆頭著者,　責任著者出版者・発行元：MDPI AG

Resistant cancer often shows a particular secretory trait such as heat shock proteins (HSPs) and extracellular vesicles (EVs), including exosomes and oncosomes surrounded by lipid bilayers. Lipoproteins are biochemical assemblies that transport hydrophobic lipid (a.k.a. fat) molecules in body fluid and are composed of a single-layer phospholipid and cholesterol outer shell, lipids molecules within the particles, and apolipoproteins embedded in the membrane. However, lipoprotein storage and secretion by cancer cells have not well-investigated yet. We found lipoproteins were stored and abundantly secreted by neuroendocrine, castration-resistant prostate cancer (NEPC / CRPC) cells but barely secreted by colon cancer cells and oral squamous cell carcinoma (OSCC) cells. In addition, large EVs (approx. 300 nm diameter) and potential oncosomes were released by CRPC and OSCC cells. Proteomics revealed that CRPC cells secreted EVs enriched with tetraspanins and extracellular matrices which were reduced upon heat shock stress and alternatively lipoproteins and HSPs were secreted upon stress. Heat shock stress triggered secretion of lipoprotein-EV complexes that contained apolipoprotein A, B, C and E. These data suggested that vesicular assembly composed of EVs and lipoproteins enriched with cholesterols and phospholipids may be stored in resistant cancer cells but released upon cell stress that is increased in cancer therapies.

DOI： 10.20944/preprints201810.0211.v1

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侵襲性歯周炎患者の血漿エクソソーム由来microRNAの発現解析

高木美奈, 山本直史, 河村麻理, 高知信介, 山城圭介, 大森一弘, 江口傑徳, 十川千春, 高柴正悟

日本歯周病学会会誌 60 ( 秋季特別 ) 134 - 134 2018年10月

Anti-EGFR antibody cetuximab is secreted by oral squamous cell carcinoma and alters EGF-driven mesenchymal transition. 査読国際誌

Toshifumi Fujiwara, Takanori Eguchi, Chiharu Sogawa, Kisho Ono, Jun Murakami, Soichiro Ibaragi, Jun-Ichi Asaumi, Kuniaki Okamoto, Stuart K Calderwood, Ken-Ichi Kozaki

Biochemical and biophysical research communications 503 ( 3 ) 1267 - 1272 2018年9月

The intranuclear PEX domain of MMP involves proliferation, migration, and metastasis of aggressive adenocarcinoma cells. 査読国際誌

Yuka Okusha, Takanori Eguchi, Chiharu Sogawa, Tatsuo Okui, Keisuke Nakano, Kuniaki Okamoto, Ken-Ichi Kozaki

Journal of cellular biochemistry 119 ( 9 ) 7363 - 7376 2018年9月

エクソソーム研究の「がん」における新展開細胞外小胞のHSPに富む特性は、転移性口腔癌細胞の生存を担う(HSP-enriched properties of extracellular vesicles involve survival of metastatic oral cancer cells)

小野喜章, 江口傑徳, 十川千春, 佐々木朗

日本癌学会総会記事 77回 897 - 897 2018年9月

急速転移性癌細胞株由来細胞外小胞による破骨細胞分化および癌細胞浸潤の制御

板垣まみ, 十川千春, 奥舎有加, 江口傑徳, 小野喜章, 岡元邦彰

Journal of Oral Biosciences Supplement 2018 347 - 347 2018年9月

大腸癌の増殖,浸潤,転移を促進するPEXドメインの役割とその制御(The intranuclear PEX domain of MMP involves proliferation, migration, and metastasis of aggressive adenocarcinoma cells)

江口傑徳, 奥舎有加, 小野喜章, 十川千春, Calderwood Stuart K., 小崎健一

日本癌学会総会記事 77回 1332 - 1332 2018年9月

Genotoxic stress induces Sca-1-expressing metastatic mammary cancer cells. 査読国際誌

Jianlin Gong, Benjamin J Lang, Desheng Weng, Takanori Eguchi, Ayesha Murshid, Thiago J Borges, Sachin Doshi, Baizheng Song, Mary A Stevenson, Stuart K Calderwood

Molecular oncology 12 ( 8 ) 1249 - 1263 2018年8月

Depletion of Lipid Efflux Pump ABCG1 Triggers the Intracellular Accumulation of Extracellular Vesicles and Reduces Aggregation and Tumorigenesis of Metastatic Cancer Cells. 査読国際誌

Yuri Namba, Chiharu Sogawa, Yuka Okusha, Hotaka Kawai, Mami Itagaki, Kisho Ono, Jun Murakami, Eriko Aoyama, Kazumi Ohyama, Jun-Ichi Asaumi, Masaharu Takigawa, Kuniaki Okamoto, Stuart K Calderwood, Ken-Ichi Kozaki, Takanori Eguchi

8 ( 376 ) 376 - 376 2018年

Monitoring of the Heat Shock Response with a Real-Time Luciferase Reporter

Toshiki Kijima, Takanori Eguchi, Len Neckers, Thomas L. Prince

Methods in Molecular Biology 35 - 45 2018年

異なる転移能を有する口腔扁平上皮癌細胞由来エクソソームに含まれるプロテオームの特性

小野喜章, 江口傑徳, 十川千春, 村上純, 藤原敏史, 笠井智成, 妹尾昌治, 佐々木朗, 小崎健一, 岡元邦彰

生命科学系学会合同年次大会 2017年度 [1LBA - 052] 2017年12月

A Tumor Suppressor Gene Product, Platelet-Derived Growth Factor Receptor-Like Protein Controls Chondrocyte Proliferation and Differentiation. 査読国際誌

Kazumi Kawata, Satoshi Kubota, Takanori Eguchi, Eriko Aoyama, Norifumi H Moritani, Morihiko Oka, Harumi Kawaki, Masaharu Takigawa

Journal of cellular biochemistry 118 ( 11 ) 4033 - 4044 2017年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY

The platelet-derived growth factor receptor-like (PDGFRL) gene is regarded as a tumor suppressor gene. However, nothing is known about the molecular function of PDGFRL. In this study, we initially clarified its function in chondrocytes. Among all cell lines examined, the PDGFRL mRNA level was the highest in chondrocytic HCS-2/8 cells. Interestingly, the proliferation of chondrocytic HCS-2/8 cells was promoted by PDGFRL overexpression, whereas that of the breast cancer-derived MDA-MB-231 cells was inhibited. Of note, in PDGFRL-overexpressing HCS-2/8 cells, the expression of chondrocyte differentiation marker genes, SOX9, ACAN, COL2A1, COL10A1, and ALP, was decreased. Moreover, we confirmed the expression of PDGFRL mRNA in normal cartilage tissue and chondrocytes. Eventually, the expression of PDGFRL mRNA in condrocytes except in the case of hypertrophic chondrocytes was demonstrated in vivo and in vitro. These findings suggest that PDGFRL plays the different roles, depending upon cell types. Particularly, in chondrocytes, PDGFRL may play a new and important role which is distinct from the function previously reported. J. Cell. Biochem. 118: 4033-4044, 2017. © 2017 Wiley Periodicals, Inc.

DOI： 10.1002/jcb.26059

Web of Science

PubMed

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Catabolic effects of FGF-1 on chondrocytes and its possible role in osteoarthritis. 査読国際誌

Abdellatif El-Seoudi, Tarek Abd El Kader, Takashi Nishida, Takanori Eguchi, Eriko Aoyama, Masaharu Takigawa, Satoshi Kubota

Journal of cell communication and signaling 11 ( 3 ) 255 - 263 2017年9月

舌癌細胞株由来エクソソーム解析による頸部リンパ節転移マーカーの探索

小野喜章, 江口傑徳, 十川千春, 村上純, 笠井智成, 妹尾昌治, 佐々木朗, 小崎健一

日本癌学会総会記事 76回 J - 1062 2017年9月

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