Organization
Faculty of Medicine, Dentistry and Pharmaceutical Sciences Assistant Professor
Position
Assistant Professor
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Junko Kobayashi
Degree
Degree
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Doctor of Philosophy in Medical Science ( 2014.12 Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences )
Research Interests
Research Interests
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Congenital heart disease
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Cardiovascular Surgery
Research Areas
Research Areas
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Life Science / Cardiovascular surgery / Congenital heart disease
Education
Education
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岡山大学大学院 医歯薬学総合研究科
2009.4 - 2014.12
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Tottori University 医学部医学科
1999.4 - 2005.3
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Research History
Research History
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岡山大学学術研究院 医歯薬学域 助教
2024.4
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岡山大学病院 助教
2021.1 - 2024.3
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岡山大学病院 医員
2020.8 - 2020.12
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カナダ トロント小児病院 クリニカルフェロー
2019.1 - 2020.6
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カナダ トロント小児病院 リサーチフェロー
2017.9 - 2018.12
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岡山大学病院 医員
2009.4 - 2017.8
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広島市立広島市民病院 医員
2007.4 - 2009.3
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医療法人近森会 近森病院 初期臨床研修医
2005.4 - 2007.3
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Professional Memberships
Professional Memberships
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The Asian Society for Cardiovascular and Thoracic Surgery
2022
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日本心臓血管外科学会
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日本外科学会
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日本循環器学会
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日本胸部外科学会
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日本小児循環器学会
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アジア心臓血管胸部外科学会
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Committee Memberships
Committee Memberships
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岡山大学病院 身体的拘束最小化チーム運営委員会
2024.11
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岡山大学 感染制御部職員会議
2024.4
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日本外科学会 代議員
2024.1
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日本外科学会 ダイバーシティ推進委員
2024.1
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岡山大学 ペイシェントセーフティマネジャー会議
2024.1
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日本医療研究開発機構 AMED課題評価委員
2022.4
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岡山大学 鎮静鎮痛管理委員会
2021.4
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岡山大学病院 安全衛生部会
2021.4
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岡山大学 教育企画委員
2021.1 - 2023.12
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日本小児循環器学会 男女共同参画検討委員会
2015.10 - 2017.7
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Papers
Papers
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When to intervene the pulmonary artery: Importance of anatomical assessment in the diagnosis of pulmonary artery coarctation. Reviewed International journal
Eiri Kisamori, Yasuhiro Kotani, Hiroyuki Suzuki, Junko Kobayashi, Takuya Kawabata, Yosuke Kuroko, Shingo Kasahara
The Journal of thoracic and cardiovascular surgery 166 ( 3 ) 926 - 932 2023.9
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Language：English Publishing type：Research paper (scientific journal)
OBJECTIVE: Pulmonary artery coarctation (PACoA) is a major problem that increases the frequency of intervention. However, there is little evidence regarding the prediction of PACoA development. METHODS: A retrospective chart review was performed on 42 patients who underwent modified Blalock-Taussig shunt and preoperative contrast-enhanced computed tomography. An uneven PA branching was defined as an abnormal ductus arteriosus connection to the left PA distal to the PA branching on contrast-enhanced computed tomography. RESULTS: Nineteen (45.2%) of 42 patients were diagnosed with PACoA. The median diameters of the ductus on the aorta and PA sides were 4.1 mm and 3.6 mm in the PACoA group and 3.6 mm and 2.9 mm in the non-PACoA group, respectively (P = .07 and .28, respectively). Tortuous ductus was recognized in 7 (36.8%) patients in the PACoA group and 14 (60.8%) patients in the non-PACoA group (P = .12). PACoA was associated with pulmonary atresia (16 patients [84.2%] in the PACoA group and 12 patients [52.1%] in the non-PACoA group) (P = .02). All 19 patients had uneven PA branching in the PACoA group, whereas 5 of 23 (21.7%) patients had uneven PA branching in the non-PACoA group (P < .001). CONCLUSIONS: Uneven PA branching rather than the ductus arteriosus size was strongly associated with PACoA development; therefore, morphologic assessment by contrast-enhanced computed tomography should be considered in patients with pulmonary atresia.
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Sachiko Kadowaki, M. Ahsan Siraj, Weiden Chen, Jian Wang, Marlee Parker, Anita Nagy, Chun‐Po Steve Fan, Kyle Runeckles, Jing Li, Junko Kobayashi, Christoph Haller, Mansoor Husain, Osami Honjo
Journal of the American Heart Association 12 ( 3 ) 2023.2
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Language：English Publishing type：Research paper (scientific journal) Publisher：Ovid Technologies (Wolters Kluwer Health)
Background
<p lang="en">Heart transplantation with a donation after circulatory death (DCD) heart is complicated by substantial organ ischemia and ischemia–reperfusion injury. Exenatide, a glucagon‐like peptide−1 receptor agonist, manifests protection against cardiac ischemia–reperfusion injury in other settings. Here we evaluate the effects of exenatide on DCD hearts in juvenile pigs.
</p> Methods and Results
<p lang="en"> DCD hearts with 15‐minutes of global warm ischemia after circulatory arrest were reperfused ex vivo and switched to working mode. Treatment with concentration 5‐nmol exenatide was given during reperfusion. DCD hearts treated with exenatide showed higher myocardial oxygen consumption (exenatide [n=7] versus controls [n=7], over 60–120 minutes of reperfusion, P <0.001) and lower cardiac troponin‐I release (27.94±11.17 versus 42.25±11.80 mmol/L, P =0.04) during reperfusion compared with controls. In working mode, exenatide‐treated hearts showed better diastolic function (dp/dt min: −3644±620 versus −2193±610 mm Hg/s, P <0.001; Tau: 15.62±1.78 versus 24.59±7.35 milliseconds, P =0.02; lateral e ′ velocity: 11.27 ± 1.46 versus 7.19±2.96, P =0.01), as well as lower venous lactate levels (3.17±0.75 versus 5.17±1.44 mmol/L, P =0.01) compared with controls. Higher levels of activated endothelial nitric oxide synthase (phosphorylated to total endothelial nitric oxide synthase levels: 2.71±1.16 versus 1.37±0.35, P =0.02) with less histological evidence of endothelial damage (von Willebrand factor expression: 0.024±0.007 versus 0.331±0.302, pixel/μm, P =0.04) was also observed with exenatide treatment versus controls.
</p> Conclusions
<p lang="en">Acute treatment of DCD hearts with exenatide limits myocardial and endothelial injury and improves donor cardiac function.
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Strategy of delayed repair of total anomalous pulmonary venous connection in right atrial isomerism and functional single ventricle. Reviewed International journal
Eiri Kisamori, Yasuhiro Kotani, Fiza Komel Raja, Junko Kobayashi, Yosuke Kuroko, Takuya Kawabata, Shingo Kasahara
JTCVS open 10 308 - 319 2022.6
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OBJECTIVE: Repair of total anomalous pulmonary venous connection (TAPVC) in neonates with right atrial isomerism and functional single ventricle is challenging. In our novel strategy, primary draining vein stenting (DVS) was applied to patients with preoperative pulmonary vein obstruction to delay TAPVC repair. This study investigated our initial experience with a strategy of delayed TAPVC repair, incorporating DVS. METHODS: Twenty-nine patients with right atrial isomerism and functional single ventricle who had a severe obstruction in the course of draining veins, who required surgical or catheter intervention in their neonatal period were retrospectively reviewed (primary DVS: n = 11; primary TAPVC repair: n = 18). RESULTS: Patients in the primary DVS group had more mixed type TAPVC (primary DVS: n = 5, 45.5%; primary TAPVC repair: n = 2, 11.1%; P = .03) and required more systemic to pulmonary shunt surgeries during their lifetime (primary DVS: n = 9, 81.8%; primary TAPVC repair: n = 6, 33.3%; P = .047). Kaplan-Meier analysis showed that primary DVS repair was associated with improved survival compared with primary TAPVC repair (survival rates at 90 days, 1 year, 3 years and 5 years: primary DVS: 100%, 80%, 68.6%, and 54.9%; primary TAPVC repair: 55.6%, 38.9%, 38.9%, and 38.9%, respectively [P = .04]). Of the 4 patients who underwent stenting of the ductus venosus, 3 had elevated liver enzymes after surgical repair of TAPVC due to ductus venosus steal, which markedly improved after coil embolization of the stent. CONCLUSIONS: For neonates with obstructive TAPVC and functional single ventricle, our delayed TAPVC repair using primary DVS appeared to improve survival compared with the conventional strategy.
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Technical modification and safe explantation of the Melody valve in the mitral position in small children Reviewed
Junko Kobayashi, Juan Contreras, Devin Chetan, Osami Honjo
JTCVS Techniques 13 209 - 210 2022.6
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Impact of pulmonary artery coarctation on pulmonary artery growth and definitive repair following modified Blalock-Taussig shunt. Reviewed International journal
Yasuhiro Kotani, Yasuyuki Kobayashi, Sachiko Kadowaki, Eiri Kisamori, Junko Kobayashi, Takuya Kawabata, Yosuke Kuroko, Shingo Kasahara
The Journal of thoracic and cardiovascular surgery 163 ( 5 ) 1618 - 1626 2022.5
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OBJECTIVE: Pulmonary artery coarctation may pose a risk for pulmonary stenosis and subsequent failure to achieve definitive repair. We sought to assess the impact of pulmonary artery coarctation on pulmonary artery growth. METHODS: A retrospective chart review was performed in 130 patients, including 37 single ventricles with a modified Blalock-Taussig shunt as first palliation. Pulmonary artery coarctation was defined as discrete stenosis of the pulmonary artery, with a diameter of less than 3 mm and with the ductus arteriosus connected. Preoperative echocardiography showed pulmonary artery coarctation in 29 patients (22%). Concomitant pulmonary artery plasty was performed in 14 patients with discrete stenosis having a diameter of less than 2 mm. RESULTS: Pre-modified Blalock-Taussig shunt left pulmonary artery z-scores were lower in patients with pulmonary artery coarctation than in those without (-4.0 [-5.8, -2.1] vs -1.7 [-2.6, -0.8], P < .001), and this remained the same even after modified Blalock-Taussig shunt (-2.5 [-5.1, -0.5] vs -0.5 [-2.4, 0.8], P = .010). Concomitant pulmonary artery plasty did not result in catch-up growth of the left pulmonary artery (post-modified Blalock-Taussig shunt left pulmonary artery z-score in patients with pulmonary artery plasty: -3.0 (-6.5, -2.0) versus those without: -1.8 (-3.3, -0.3), P = .279). Definitive repair/Fontan completion was achieved in 111 patients (85%), and this was not affected by the presence of pulmonary artery coarctation. CONCLUSIONS: Pulmonary artery coarctation affected disproportionate pulmonary artery growth throughout the staged repair, but did not result in failure of definitive repair/Fontan completion. Pulmonary artery plasty during the neonatal period did not contribute to catch-up growth of the left pulmonary artery; therefore, surgical indications and timing should be carefully considered.
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未来の専門医を育てる！岡山大学心臓血管外科の教育論－過去からの伝承と新たな展開－
小林純子、笠原真悟
胸部外科 2022
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Strategy of delayed repair of total anomalous pulmonary venous connection in right atrial isomerism and functional single ventricle Reviewed
Kisamori E, Kotani Y, Fiza Komel Raja, Kobayashi J, Kuroko Y, Kawabata T, Kasahara S
10 308 - 319 2022
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Language：English
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Technical modification and safe explantation of the Melody valve in the mitral position in small children Reviewed
Kobayashi J, Contreras J, Chetan D, Honjo O
JTCVS techniques 2022
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Flow-targeted pediatric ex vivo heart perfusion in donation after circulatory death: A porcine model. Reviewed International journal
Junko Kobayashi, Shuhua Luo, Yohei Akazawa, Marlee Parker, Jian Wang, David Chiasson, Mark K Friedberg, Christoph Haller, Osami Honjo
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 39 ( 3 ) 267 - 277 2020.3
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BACKGROUND: The optimal blood flow and pressure to perfuse pediatric hearts from donation after circulatory death (DCD) on the ex vivo perfusion system has not been elucidated. This study sought to investigate the optimal perfusion strategy for pediatric DCD hearts by using a juvenile porcine model comparing pressure- vs flow-targeted strategy. METHODS: The hearts of the juvenile DCD pigs were explanted, and the coronary arteries were perfused for 2 hours by the ex vivo heart perfusion system with 2 different perfusion strategies; pressure-targeted perfusion (target coronary perfusion pressure: 40 mm Hg, group A) and flow-targeted perfusion (target coronary perfusion flow: 10 ml/kg/min, group B). The working model heart perfusion was used to assess systolic and diastolic myocardial performance. RESULTS: The body weight, warm and cold ischemic time, and ex vivo perfusion time were comparable between the groups. In the working model, group B showed significantly preserved cardiac output (A: 70.5 ± 15.3 ml/kg/min vs B: 113.8 ± 15.0 ml/kg/min, p < 0.01), stroke volume (A: 0.4 ± 0.1 ml/kg vs B: 0.7 ± 0.1 ml/kg, p < 0.01), and ejection fraction (A: 18.8% ± 5.9% vs B: 35.0% ± 10.6%, p < 0.01). E/e' and Tei index were also significantly preserved in group B. The percentage gain of heart weight after ex vivo (net increase of the heart weight divided by heart weight at baseline) was significantly smaller in group B (A: 20.0% ± 5.3% vs B: 11.6% ± 5.0%, p < 0.05). Troponin-I, myocardial hemorrhage, oxidative stress markers; myeloperoxidase and 8-hydroxy-2'-deoxyguanosine were also significantly lower after ex vivo perfusion in group B (p < 0.05). CONCLUSIONS: The tightly controlled flow-targeted myocardial perfusion strategy for DCD donor hearts achieved better myocardial performance by causing less myocardial edema and limiting myocardial reperfusion injury.
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Fontan手術到達例から見たAsplenia syndromeの外科治療の成績 Reviewed
笠原 真悟, 井上 善紀, 川田 幸子, 佐野 俊和, 堀尾 直裕, 小林 純子, 石神 修大, 藤井 泰宏, 黒子 洋介, 小谷 恭弘, 新井 禎彦
日本小児循環器学会雑誌 33 ( Suppl.1 ) s1 - 188 2017.7
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Intracoronary Cardiac Progenitor Cells in Single Ventricle Physiology: The PERSEUS (Cardiac Progenitor Cell Infusion to Treat Univentricular Heart Disease) Randomized Phase 2 Trial. Reviewed International journal
Shuta Ishigami, Shinichi Ohtsuki, Takahiro Eitoku, Daiki Ousaka, Maiko Kondo, Yoshihiko Kurita, Kenta Hirai, Yosuke Fukushima, Kenji Baba, Takuya Goto, Naohiro Horio, Junko Kobayashi, Yosuke Kuroko, Yasuhiro Kotani, Sadahiko Arai, Tatsuo Iwasaki, Shuhei Sato, Shingo Kasahara, Shunji Sano, Hidemasa Oh
Circulation research 120 ( 7 ) 1162 - 1173 2017.3
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RATIONALE: Patients with single ventricle physiology are at high risk of mortality resulting from ventricular dysfunction. The preliminary results of the phase 1 trial showed that cardiosphere-derived cells (CDCs) may be effective against congenital heart failure. OBJECTIVE: To determine whether intracoronary delivery of autologous CDCs improves cardiac function in patients with single ventricle physiology. METHODS AND RESULTS: We conducted a phase 2 randomized controlled study to assign in a 1:1 ratio 41 patients who had single ventricle physiology undergoing stage 2 or 3 palliation to receive intracoronary infusion of CDCs 4 to 9 weeks after surgery or staged reconstruction alone (study A). The primary outcome measure was to assess improvement in cardiac function at 3-month follow-up. Four months after palliation, controls had an alternative option to receive late CDC infusion on request (study B). Secondary outcomes included ventricular function, heart failure status, somatic growth, and health-related quality of life after a 12-month observation. At 3 months, the absolute changes in ventricular function were significantly greater in the CDC-treated group than in the controls (+6.4% [SD, 5.5] versus +1.3% [SD, 3.7]; P=0.003). In study B, a late CDC infusion in 17 controls increased the ventricular function at 3 months compared with that at baseline (38.8% [SD, 7.7] versus 34.8% [SD, 7.4]; P<0.0001). At 1 year, overall CDC infusion was associated with improved ventricular function (41.4% [SD, 6.6] versus 35.0% [SD, 8.2]; P<0.0001) and volumes (P<0.001), somatic growth (P<0.0001) with increased trophic factors production, such as insulin-like growth factor-1 and hepatocyte growth factor, and quality of life, along with a reduced heart failure status (P<0.0001) and cardiac fibrosis (P=0.014) relative to baseline. CONCLUSIONS: Intracoronary infusion of CDCs after staged palliation favorably affected cardiac function by reverse remodeling in patients with single ventricle physiology. This impact may improve heart failure status, somatic growth, and quality of life in patients and reduce parenting stress for their families. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01829750.
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左冠動脈大動脈起始22例における長期成績の検討
川田 幸子, 小谷 恭弘, 岸 良匡, 枝木 大治, 小林 泰幸, 衛藤 弘城, 堀尾 直裕, 石神 修大, 後藤 拓弥, 奥山 倫弘, 小林 純子, 藤井 泰宏, 新井 禎彦, 笠原 真悟, 佐野 俊二
日本心臓血管外科学会学術総会抄録集 47回 213 - 213 2017.2
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小児大動脈弁疾患の外科治療戦略 新生児・乳児期の先天性大動脈弁狭窄症に対する治療戦略と遠隔期成績
笠原 真悟, 佐野 俊和, 堀尾 直裕, 後藤 拓弥, 小林 純子, 衛藤 弘城, 石神 修大, 藤井 泰宏, 黒子 洋介, 大澤 晋, 小谷 恭弘, 増田 善逸, 新井 禎彦, 佐野 俊二
日本心臓血管外科学会学術総会抄録集 47回 474 - 474 2017.2
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Fontan手術の将来展望 遠隔成績から検討した当院の段階的治療戦略
笠原 真悟, 堀尾 直裕, 佐野 俊和, 後藤 拓弥, 小林 純子, 衛藤 弘城, 石神 修大, 藤井 泰宏, 大澤 晋, 黒子 洋介, 小谷 恭弘, 増田 善逸, 新井 禎彦, 佐野 俊二
日本心臓血管外科学会学術総会抄録集 47回 750 - 750 2017.2
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左側房室弁の外科治療 AVSDに対するmodified single patch repair Reviewed
笠原 真悟, 佐野 俊和, 堀尾 直裕, 小林 純子, 石神 修大, 藤井 泰宏, 黒子 洋介, 小谷 恭弘, 新井 禎彦, 佐野 俊二
日本小児循環器学会雑誌 32 ( Suppl.1 ) s1 - 115 2016.7
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HLHSの外科治療 合併症回避のための治療戦略 左心低形成症候群に対する連続135例のModified Norwood-Sano手術の治療成績
笠原 真悟, 枝木 大治, 佐野 俊和, 木村 紘爾, 堀尾 直裕, 後藤 拓弥, 小林 純子, 石神 修大, 藤井 泰宏, 黒子 洋介, 小谷 恭弘, 大澤 晋, 増田 善逸, 新井 禎彦, 佐野 俊二
日本心臓血管外科学会学術総会抄録集 46回 PD2 - 1 2016.2
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Dissecting the Left Heart Hypoplasia by Pluripotent Stem Cells
Junko Kobayashi, Shunji Sano, Hidemasa Oh
337 - 339 2016
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Authorship：Lead author Language：English Publisher：Springer
The genetic background of hypoplastic left heart syndrome (HLHS) is still unknown. Cardiac differentiation from pluripotent stem cells (PSCs) can recapitulate the cardiogenesis in vitro, and PSC technology could be useful to dissect the diseases with the complex mechanisms. In the past few years, some researches were reported to seek the pathogenesis of HLHS by using PSCs. This paper reports the achievements.
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小児大動脈弁疾患の治療戦略 新生児・乳児期の大動脈狭窄症に対する治療戦略と遠隔期成績
笠原 真悟, 川畑 拓也, 小林 純子, 石神 修大, 藤井 泰宏, 黒子 洋介, 小谷 恭弘, 増田 善逸, 吉積 功, 新井 禎彦, 佐野 俊二
日本小児循環器学会雑誌 31 ( Suppl.1 ) s1 - 114 2015.7
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症例から学ぶフォンタン循環病態 フォンタン循環への選択からその破綻への対応 Fontan手術の達成率を如何に高めるか 遠隔成績症例の検討した当院の段階的手術治療
笠原 真悟, 堀尾 直裕, 小林 純子, 石神 修大, 藤井 泰宏, 黒子 洋介, 小谷 恭弘, 増田 善逸, 吉積 功, 新井 禎彦, 佐野 俊二
日本小児循環器学会雑誌 31 ( Suppl.1 ) s1 - 125 2015.7
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Intracoronary autologous cardiac progenitor cell transfer in patients with hypoplastic left heart syndrome: the TICAP prospective phase 1 controlled trial. Reviewed International journal
Shuta Ishigami, Shinichi Ohtsuki, Suguru Tarui, Daiki Ousaka, Takahiro Eitoku, Maiko Kondo, Michihiro Okuyama, Junko Kobayashi, Kenji Baba, Sadahiko Arai, Takuya Kawabata, Ko Yoshizumi, Atsushi Tateishi, Yosuke Kuroko, Tatsuo Iwasaki, Shuhei Sato, Shingo Kasahara, Shunji Sano, Hidemasa Oh
Circulation research 116 ( 4 ) 653 - 64 2015.2
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Language：English Publishing type：Research paper (scientific journal)
RATIONALE: Hypoplastic left heart syndrome (HLHS) remains a lethal congenital cardiac defect. Recent studies have suggested that intracoronary administration of autologous cardiosphere-derived cells (CDCs) may improve ventricular function. OBJECTIVE: The aim of this study was to test whether intracoronary delivery of CDCs is feasible and safe in patients with hypoplastic left heart syndrome. METHODS AND RESULTS: Between January 5, 2011, and January 16, 2012, 14 patients (1.8±1.5 years) were prospectively assigned to receive intracoronary infusion of autologous CDCs 33.4±8.1 days after staged procedures (n=7), followed by 7 controls with standard palliation alone. The primary end point was to assess the safety, and the secondary end point included the preliminary efficacy to verify the right ventricular ejection fraction improvements between baseline and 3 months. Manufacturing and intracoronary delivery of CDCs were feasible, and no serious adverse events were reported within the 18-month follow-up. Patients treated with CDCs showed right ventricular ejection fraction improvement from baseline to 3-month follow-up (46.9%±4.6% to 52.1%±2.4%; P=0.008). Compared with controls at 18 months, cardiac MRI analysis of CDC-treated patients showed a higher right ventricular ejection fraction (31.5%±6.8% versus 40.4%±7.6%; P=0.049), improved somatic growth (P=0.0005), reduced heart failure status (P=0.003), and lower incidence of coil occlusion for collaterals (P=0.007). CONCLUSIONS: Intracoronary infusion of autologous CDCs seems to be feasible and safe in children with hypoplastic left heart syndrome after staged surgery. Large phase 2 trials are warranted to examine the potential effects of cardiac function improvements and the long-term benefits of clinical outcomes. CLINICAL TRIAL REGISTRATION URL: http://www.clinicaltrials.gov. Unique identifier: NCT01273857.
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Novel Model of Pulmonary Artery Banding Leading to Right Heart Failure in Rats. Reviewed International journal
Masataka Hirata, Daiki Ousaka, Sadahiko Arai, Michihiro Okuyama, Suguru Tarui, Junko Kobayashi, Shingo Kasahara, Shunji Sano
BioMed research international 2015 753210 - 753210 2015
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BACKGROUND: Congenital heart diseases often involve chronic pressure overload of the right ventricle (RV) which is a major cause of RV dysfunction. Pulmonary artery (PA) banding has been used to produce animal models of RV dysfunction. We have devised a new and easier method of constricting the PA and compared it directly with the partial ligation method. METHODS: Eight-week-old male Sprague-Dawley rats (240-260 g) were divided into three groups: sham operation, partial pulmonary artery ligation (PAL) procedure, and pulmonary artery half-closed clip (PAC) procedure. RV function and remodeling were determined by echocardiography and histomorphometry. RESULTS: Surgical mortality was significantly lower in the PAC group while echocardiography revealed significantly more signs of RV dysfunction. At the 8th week after surgery RV fibrosis rate was significantly higher in the PAC group. CONCLUSIONS: This procedure of pulmonary artery banding in rats is easier and more efficient than partial ligation.
DOI： 10.1155/2015/753210
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Epigenetic modification in congenital heart diseases by using stem cell technologies Reviewed
Kobayashi J, Sano S, Oh H
Stem Cell Epigenetics 2 e550 2015
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Congenital Heart Diseases and Disease-specifi¬c iPS Cells
Kobayashi J, Sano S, Oh H
Pediatric Cardiology and Cardiac Surgery 31 ( 4 ) 138 - 147 2015
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Directed differentiation of patient-specific induced pluripotent stem cells identifies the transcriptional repression and epigenetic modification of NKX2-5, HAND1, and NOTCH1 in hypoplastic left heart syndrome. Reviewed International journal
Junko Kobayashi, Masashi Yoshida, Suguru Tarui, Masataka Hirata, Yusuke Nagai, Shingo Kasahara, Keiji Naruse, Hiroshi Ito, Shunji Sano, Hidemasa Oh
PloS one 9 ( 7 ) e102796 2014
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The genetic basis of hypoplastic left heart syndrome (HLHS) remains unknown, and the lack of animal models to reconstitute the cardiac maldevelopment has hampered the study of this disease. This study investigated the altered control of transcriptional and epigenetic programs that may affect the development of HLHS by using disease-specific induced pluripotent stem (iPS) cells. Cardiac progenitor cells (CPCs) were isolated from patients with congenital heart diseases to generate patient-specific iPS cells. Comparative gene expression analysis of HLHS- and biventricle (BV) heart-derived iPS cells was performed to dissect the complex genetic circuits that may promote the disease phenotype. Both HLHS- and BV heart-derived CPCs were reprogrammed to generate disease-specific iPS cells, which showed characteristic human embryonic stem cell signatures, expressed pluripotency markers, and could give rise to cardiomyocytes. However, HLHS-iPS cells exhibited lower cardiomyogenic differentiation potential than BV-iPS cells. Quantitative gene expression analysis demonstrated that HLHS-derived iPS cells showed transcriptional repression of NKX2-5, reduced levels of TBX2 and NOTCH/HEY signaling, and inhibited HAND1/2 transcripts compared with control cells. Although both HLHS-derived CPCs and iPS cells showed reduced SRE and TNNT2 transcriptional activation compared with BV-derived cells, co-transfection of NKX2-5, HAND1, and NOTCH1 into HLHS-derived cells resulted in synergistic restoration of these promoters activation. Notably, gain- and loss-of-function studies revealed that NKX2-5 had a predominant impact on NPPA transcriptional activation. Moreover, differentiated HLHS-derived iPS cells showed reduced H3K4 dimethylation as well as histone H3 acetylation but increased H3K27 trimethylation to inhibit transcriptional activation on the NKX2-5 promoter. These findings suggest that patient-specific iPS cells may provide molecular insights into complex transcriptional and epigenetic mechanisms, at least in part, through combinatorial expression of NKX2-5, HAND1, and NOTCH1 that coordinately contribute to cardiac malformations in HLHS.
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Aberrant Calcium Handling Inhibits Functional Maturation and Excitation in Factors-based Human Cardiomyocytes Differentiation Reviewed
Suguru Tarui, Junko Kobayashi, Masataka Hirata, Ken Takahashi, Gentaro Iribe, Keiji Naruse, Shingo Kasahara, Shunji Sano, Hidemasa Ou
JOURNAL OF CARDIAC FAILURE 18 ( 10 ) S146 - S146 2012.10
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Language：English Publishing type：Research paper (scientific journal) Publisher：CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
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Stem cell interventions in patients with congenital heart disease
Kobayashi J, Sano S, Oh H
Cardiology 71 ( 4 ) 360 - 368 2012
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Left ventricular free wall rupture followed by papillary muscle rupture combined with acute myocardial infarction Reviewed
Kobayashi J, Yoshida H, Kato H, Suzuki T, Mohri M, Yunoki K, Hisamochi K, Oba O
Jpn J Cardiovasc Surg 39 ( 3 ) 129 - 132 2010
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Early postoperative recovery by chronic dialysis patients after coronary artery bypass grafting. Reviewed
Junko Kobayashi, Masahiko Ikebuchi, Yasufumi Fujita, Hiroyuki Irie
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 15 ( 4 ) 243 - 6 2009.8
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Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
OBJECTIVE: A faster start at rehabilitation has been a great benefit in reducing complications and costs after coronary artery bypass grafting (CABG). We studied early postoperative recovery from CABG in dialysis patients. METHODS: From January 2001 to May 2006, a total of 401 patients underwent isolated CABG at our institution. We retrospectively studied 348 consecutive elective cases, which were divided into two groups; 18 with dialysis (group D) and 330 without dialysis (group N), with respect to having meals, standing, and walking. RESULTS: An analysis of patient demographics revealed significant differences in gender, comorbidity of old cerebral infarction, anemia, and water balance during operation (P <0.05). Operative and in-hospital mortalities were 0% in group D. The percentages of the patients who were eating meals, standing, or walking on postoperative day (POD) 1 in group D were 88.9%, 66.6%, and 27.8%, respectively. In group N, these percentages were significantly higher: 96.1%, 85.5%, and 75.8%. But by POD 2, these values became similar. We considered that the delay of rehabilitation in group D was mainly due to hemodialysis on POD 1. CONCLUSION: Early postoperative recovery from elective isolated CABG in dialysis patients delayed a day against nondialysis patients. The delay was considered a result of the inevitable dialysis on POD 1.
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[A case of long survival of a scirrhous gastric cancer patient with esophageal invasion and peritoneal dissemination through chemotherapy and palliative surgery].
Shinsuke Sasada, Motoki Ninomiya, Junko Kobayashi, Masahiko Nishizaki, Norihisa Takakura
Gan to kagaku ryoho. Cancer & chemotherapy 35 ( 9 ) 1551 - 4 2008.9
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Language：Japanese Publishing type：Research paper (scientific journal)
We report a case of advanced scirrhous gastric cancer treated by operation and chemotherapy for over four years. The patient was a 54-year-old female who had suffered from gastric cancer with esophageal invasion. She underwent total gastrectomy with D2 dissection. Operative findings revealed peritoneal dissemination, and it resulted in non-curative resection. After surgery, combination chemotherapy with low-dose CDDP administered intraperitoneally and S-1, combination chemotherapy with paclitaxel and 5-FU, and then combination chemotherapy with docetaxel and S-1 were sequentially performed. She also underwent palliative surgery for intestinal obstruction resulting from carcinomatous peritonitis. She achieved long survival with good quality of life (QOL) by multidisciplinary therapy of chemotherapy and surgical operation.
Books
Books
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DOCTOR'S MAGAZINE
2022.6
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MISC
MISC
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当院における1.5心室修復術後遠隔期成績
井上善紀, 岸良匡, 堀川優衣, 枝木大治, 小松弘明, 辻龍典, 小林純子, 川畑拓也, 黒子洋介, 小谷恭弘, 笠原真悟
日本小児循環器学会総会・学術集会(Web) 59th 2023
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特発性左外腸骨静脈破裂に対する治療経験例からの外科的術式の考察
森岡 慧, 鈴木 浩之, 枝木 大治, 小松 弘明, 辻 龍典, 横田 豊, 迫田 直也, 村岡 玄也, 小林 純子, 川畑 拓也, 黒子 洋介, 小谷 恭弘, 加藤 源太郎, 廣田 真規, 笠原 真悟
日本血管外科学会雑誌 32 ( Suppl. ) P17 - 2 2023
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未来の専門医を育てる！岡山大学心臓血管外科の教育論－過去からの伝承と新たな展開－
小林純子, 笠原真悟
胸部外科 75 ( 8 ) 630 - 633 2022.8
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Authorship：Lead author Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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DCD動物モデルにおける体外両心機能評価の検討
小谷恭弘, 小林泰幸, 門脇幸子, 枝木大治, 迫田直也, 小林純子, 川畑拓也, 黒子洋介, 廣田真規, 笠原真悟
日本心臓移植研究会学術集会プログラム・抄録集(Web) 41st 2022
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全国の医局情報をPick Up 19関連施設で年間5000件の心臓手術！75施設での外科研修プログラム
小林純子
2022
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Authorship：Lead author, Last author, Corresponding author
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新生児・乳児期の先天性大動脈弁狭窄症に対する治療戦略と遠隔期成績
笠原真悟, 小谷恭弘, 鈴木浩之, 木佐森永理, 枝木大治, 小松弘明, 小林泰幸, 辻龍典, 迫田直也, 横田豊, 村岡玄哉, 小林純子, 黒子洋介, 川畑拓也
日本心臓病学会学術集会(Web) 69th 2021
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新生児開心術の工夫 当院における新生児開心術 26年間の変遷、工夫と治療成績
小谷 恭弘, 黒子 洋介, 新井 禎彦, 小林 純子, 佐野 俊和, 後藤 拓弥, 堀尾 直裕, 川田 幸子, 小林 泰幸, 村岡 玄哉, 奥山 倫弘, 衛藤 弘城, 大澤 晋, 増田 善逸, 佐野 俊二, 笠原 真悟
日本外科学会定期学術集会抄録集 118回 478 - 478 2018.4
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左心低形成症候群に対するprimary Norwood手術 手術成績向上のためのRV-PA shuntによるNorwood手術連続138例の検討
笠原 真悟, 佐野 俊和, 堀尾 直裕, 小林 純子, 石神 修大, 藤井 泰宏, 黒子 洋介, 小谷 恭弘, 新井 禎彦, 佐野 俊二
日本小児循環器学会雑誌 32 ( Suppl.1 ) s1 - 185 2016.7
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Disease-Specific Induced Pluripotent Stem Cells Identify the Transcriptional Repression and Epigenetic Modification of NKX2-5, HAND1, and NOTCH1 During Cardiac Development of Hypoplastic Left Heart Syndrome
Junko Kobayashi, Masashi Yoshida, Suguru Tarui, Shuta Ishigami, Michihiro Okuyama, Yusuke Nagai, Shingo Kasahara, Keiji Naruse, Hiroshi Ito, Shunji Sano, Hidemasa Oh
CIRCULATION 130 2014.11
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Language：English Publishing type：Research paper, summary (international conference) Publisher：LIPPINCOTT WILLIAMS & WILKINS
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Intracoronary Delivery of Autologous Cardiac Progenitor Cells in Children With Hypoplastic Left Heart Syndrome: The Ticap Trial With 18-Month Follow Up
Shuta Ishigami, Suguru Tarui, Michihiro Okuyama, Daiki Ousaka, Shinichi Ohtsuki, Takahiro Eitoku, Junko Kobayashi, Shingo Kasahara, Shunji Sano, Hidemasa Oh
CIRCULATION 130 2014.11
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Language：English Publishing type：Research paper, summary (international conference) Publisher：LIPPINCOTT WILLIAMS & WILKINS
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Late Gadolinium Enhancement on Cardiac MRI Identifies Ventricular Dysfunction and Regional Myocardial Dyssynchrony in Patients with Univentricular Heart Diseases
Michihiro Okuyama, Shuta Ishigami, Daiki Ousaka, Junko Kobayashi, Shingo Kasahara, Shunji Sano, Hidemasa Oh
CIRCULATION RESEARCH 115 2014.7
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Language：English Publishing type：Research paper, summary (international conference) Publisher：LIPPINCOTT WILLIAMS & WILKINS
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Intracoronary Autologous Cardiac Progenitor Cell Transfer In Children With Hypoplastic Left Heart Syndrome: 2-year Results Of The Ticap Trial
Shuta Ishigami, Suguru Tarui, Michihiro Okuyama, Daiki Ousaka, Junko Kobayashi, Shingo Kasahara, Shunji Sano, Hidemasa Oh
CIRCULATION RESEARCH 115 2014.7
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Language：English Publishing type：Research paper, summary (international conference) Publisher：LIPPINCOTT WILLIAMS & WILKINS
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Patient-specific Induced Pluripotent Stem Cells For Modeling Hypoplastic Left Heart Syndrome
Junko Kobayashi, Masashi Yoshida, Suguru Tarui, Masataka Hirata, Ken Takahashi, Shingo Kasahara, Keiji Naruse, Hiroshi Ito, Shunji Sano, Hidemasa Oh
CIRCULATION 126 ( 21 ) 2012.11
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Language：English Publishing type：Research paper, summary (international conference) Publisher：LIPPINCOTT WILLIAMS & WILKINS
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Factors-based Human Cardiomyocytes Differentiation Exhibits Defective Maturation and Excitation Through Aberrant Calcium Handling Proteins
Suguru Tarui, Junko Kobayashi, Masataka Hirata, Ken Takahashi, Gentaro Iribe, Keiji Naruse, Shingo Kasahara, Shunji Sano, Hidemasa Oh
CIRCULATION 126 ( 21 ) 2012.11
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Language：English Publishing type：Research paper, summary (international conference) Publisher：LIPPINCOTT WILLIAMS & WILKINS
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Hedgehog Interacting Protein Controls Age-Dependent Angiogenic Activity in Human Cardiac Progenitor Cells Through Insulin-Like Growth Factor-1 Receptor Signaling
Masashi Yoshida, Suguru Tarui, Junko Kobayashi, Masataka Hirata, Yasufumi Kijima, Tohru Miyoshi, Kazufumi Nakamura, Kengo Kusano, Youhei Maeshima, Shunji Sano, Hiroshi Ito, Hidemasa Oh
CIRCULATION 126 ( 21 ) 2012.11
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Language：English Publishing type：Research paper, summary (international conference) Publisher：LIPPINCOTT WILLIAMS & WILKINS
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笠原真悟, 平田昌敬, 小林純子, 樽井俊, 川畑拓也, 黒子洋介, 大澤晋, 立石篤史, 藤田康文, 吉積功, 高垣昌巳, 新井禎彦, 佐野俊二
日本心臓血管外科学会雑誌 41 ( Supplement ) 174 - 174 2012.3
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動脈スイッチ手術の長期治療成績(Long-term results of arterial switch operation)
立石 篤史, 笠原 真悟, 奥山 倫弘, 小林 純子, 平田 昌敬, 樽井 俊, 大澤 晋, 川畑 拓也, 黒子 洋介, 藤田 康文, 吉積 功, 新井 禎彦, 高垣 昌巳, 佐野 俊二
日本心臓血管外科学会雑誌 41 ( Suppl. ) 394 - 394 2012.3
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Presentations
Presentations
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小児大動脈弁閉鎖不全症に対するRoss手術
門脇幸子, 枝木大治, 小松弘明, 鈴木浩之, 井上善紀, 岸 良匡, 森岡 慧, 清水春菜, 倉田裕次, 徳田雄平, 吉田文哉, 古谷凌一, 山田隆明, 小林純子, 加藤源太郎, 柚木継二, 藤井泰宏, 黒子洋介, 小谷恭弘, 笠原真悟
第185回岡山外科会・第8回日本臨床外科学会岡山県支部会 2024.12.21
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大動脈緊急症
柚木継二, 井上善紀, 加藤源太郎, 古谷凌一, 山田隆明, 吉田文哉, 清水春菜, 倉田裕次, 徳田雄平, 森岡 慧, 岸 良匡, 鈴木浩之, 枝木大治, 小松弘明, 門脇幸子, 小林純子, 藤井泰宏, 黒子洋介, 小谷恭弘, 笠原真悟
第185回岡山外科会・第8回日本臨床外科学会岡山県支部会 2024.12.21
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脳血流維持のためのECMO下TAVI頚動脈アプローチの経験
井上善紀, 加藤源太郎, 柚木継二, 門田悠暉, 木下 萌, 倉田裕次, 徳田雄平, 森岡 慧, 岸 良匡, 清水春菜, 鈴木浩之, 枝木大治, 小松弘明, 門脇幸子, 小林純子, 藤井泰宏, 黒子洋介, 小谷恭弘, 笠原真悟, 戸田洋伸, 三木崇史
第125回日本循環器学会中国地方会 2024.12.1
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Event date： 2024.11.30 - 2024.12.1
Language：Japanese Presentation type：Oral presentation (general)
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無脾症候群合併の単心室症例における肺動脈形成と Additional pulmonary blood flow を併用した中心肺動脈の成長促進
小林純子, 徳田雄平, 倉田裕次, 森岡 慧, 清水春菜, 岸 良匡, 鈴木浩之, 井上善紀, 枝木大治, 小松弘明, 藤井泰宏, 加藤源太郎, 柚木継二, 黒子洋介, 小谷恭弘, 笠原真悟
第77回日本胸部外科学会定期学術集会 2024.11.3
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Event date： 2024.11.1 - 2024.11.4
Language：Japanese Presentation type：Oral presentation (general)
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心室中隔欠損を伴う肺動脈閉鎖症に対する自己組織を用いた右室流出路再建
木村綾梨, 小谷恭弘, 小林泰幸, 徳田雄平, 小林純子, 黒子洋介, 笠原真悟
第77回日本胸部外科学会定期学術集会 2024.11.3
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Event date： 2024.11.1 - 2024.11.4
Language：Japanese Presentation type：Oral presentation (general)
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Pulmonary artery coarctationに対する肺動脈形成術の治療成績
黒子洋介, 倉田裕次, 徳田雄平, 森岡 慧, 清水春菜, 鈴木浩之, 岸 良匡, 井上善紀, 枝木大治, 小松弘明, 小林純子, 藤井泰宏, 小谷恭弘, 加藤源太郎, 柚木継二, 笠原真悟
第77回日本胸部外科学会定期学術集会 2024.11.2
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Event date： 2024.11.1 - 2024.11.4
Language：Japanese Presentation type：Symposium, workshop panel (public)
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当院における先天性僧帽弁閉鎖不全症に対する治療成績の検討
清水春菜, 小谷恭弘, 木下 萌, 門田悠暉, 倉田裕次, 徳田雄平, 森岡 慧, 岸 良匡, 鈴木浩之, 井上善紀, 枝木大治, 小松弘明, 藤井泰宏, 加藤源太郎, 柚木継二, 小林純子, 黒子洋介, 笠原真悟
第77回日本胸部外科学会定期学術集会 2024.11.2
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Event date： 2024.11.1 - 2024.11.4
Language：Japanese Presentation type：Oral presentation (general)
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海外の報告からみた成人先天性心疾患患者の心移植におけるわが国の問題点
黒子洋介, 岩崎慶一朗, 小林純子, 角南春樹, 杜 徳尚, 小谷恭弘, 中村一文, 赤木禎治, 湯浅慎介, 笠原真悟
第60回日本移植学会総会 2024.9.14
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Event date： 2024.9.12 - 2024.9.14
Language：Japanese Presentation type：Symposium, workshop panel (public)
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血行動態シミュレーションが導く、「失敗しない」先天性心臓手術
小林純子
第29回岡山大学外科MCセミナー 2024.9.7
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小児先天性心疾患での当院の標準術式である右腋下縦切開と正中切開との比較検討
笠原真悟, 小林純子, 黒子洋介, 小谷恭弘
第99回中国四国外科学会総会・第29回中国四国内視鏡外科研究会 2024.9.5
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Event date： 2024.9.5 - 2024.9.6
Language：Japanese Presentation type：Symposium, workshop panel (public)
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ある外科医の透析内シャント設置術ラーニングカーブからの外科医教育に関する考察
藤井泰宏, 笠原真悟, 小谷恭弘, 黒子洋介, 柚木継二, 加藤源太郎, 小林純子
第99回中国四国外科学会総会・第29回中国四国内視鏡外科研究会 2024.9.5
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Event date： 2024.9.5 - 2024.9.6
Language：Japanese Presentation type：Oral presentation (general)
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進行性の骨盤内圧排症状を呈した100mm大の右腸骨動脈嚢状瘤切迫破裂に対し、人工血管置換術を施行した一例
徳田雄平, 加藤源太郎, 門田悠暉, 木下 萌, 倉田裕次, 清水春菜, 森岡 慧, 岸 良匡, 鈴木浩之, 枝木大治, 小松弘明, 井上善紀, 小林純子, 藤井泰宏, 黒子洋介, 柚木継二, 小谷恭弘, 笠原真悟
日本血管外科学会中国四国地方会第54回総会 2024.8.3
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小児心臓血管外科の地域拠点化に向けて―中国四国地方の現況と問題点―
笠原真悟, 井上善紀, 小林純子, 黒子洋介, 小谷恭弘
第60回日本小児循環器学会総会・学術集会 2024.7.13
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Event date： 2024.7.11 - 2024.7.13
Language：Japanese Presentation type：Symposium, workshop panel (nominated)
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先天性心疾患術後三尖弁逆流に対する弁形成術を施行した4症例の検討
徳田雄平, 小谷恭弘, 森岡 慧, 成宮悠仁, 岸 良匡, 鈴木浩之, 枝木大治, 小松弘明, 小林純子, 黒子洋介, 笠原真悟
第60回日本小児循環器学会総会・学術集会 2024.7.13
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Event date： 2024.7.11 - 2024.7.13
Language：Japanese Presentation type：Poster presentation
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先天性一側肺動脈欠損症の４症例
枝木大治, 黒子洋介, 徳田雄平, 鈴木浩之, 井上善紀, 小松弘明, 小林純子, 藤井泰宏, 加藤源太郎, 小谷恭弘, 笠原真悟
第60回日本小児循環器学会総会・学術集会 2024.7.13
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Event date： 2024.7.11 - 2024.7.13
Language：Japanese Presentation type：Poster presentation
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成人期 Ebstein病の治療戦略
笠原真悟, 小林純子, 黒子洋介, 小谷恭弘
第60回日本小児循環器学会総会・学術集会 2024.7.11
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Event date： 2024.7.11 - 2024.7.13
Language：Japanese Presentation type：Symposium, workshop panel (public)
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完全大血管転位症に対するArterial switch operationの工夫：Open techniqueとmedially hinged trap-door法
小林純子, 黒子洋介, 小谷恭弘, 笠原真悟
第60回日本小児循環器学会総会・学術集会 2024.7.11
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Event date： 2024.7.11 - 2024.7.13
Language：Japanese Presentation type：Symposium, workshop panel (public)
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Modified single patch technique for CAVSD patients
黒子洋介, 小林泰幸, 小林純子, 小谷恭弘, 笠原真悟
第5回CHSS Japan手術手技研究会 2024.7.11
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CTでRVの穿孔が疑われたペースメーカーリードを抜去し、再植え込みを行った一手術例
井上善紀, 加藤源太郎, 倉田裕次, 徳田雄平, 森岡 慧, 成宮悠仁, 岸 良匡, 鈴木浩之, 枝木大治, 小松弘明, 藤井泰宏, 小林純子, 黒子洋介, 小谷恭弘, 笠原真悟, 宮本真和, 上岡 亮, 西井伸洋
第124回日本循環器学会中国・四国合同地方会 2024.6.22
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Event date： 2024.6.22 - 2024.6.23
Language：Japanese Presentation type：Oral presentation (general)
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TAVI弁感染に対して摘出および外科的AVRを要した1例
倉田裕次, 加藤源太郎, 井上善紀, 柚木継二, 笠原真悟, 小谷恭弘, 黒子洋介, 藤井泰宏, 小林純子
第67回関西胸部外科学会学術集会 2024.6.13
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Event date： 2024.6.13 - 2024.6.14
Language：Japanese Presentation type：Oral presentation (general)
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外科手術におけるジェンダー・バイアスへの取り組み：多様性を育みSDGsを達成するためのアプローチ
竹原裕子, 小林純子, 溝尾妙子, 高橋侑子
第124回日本外科学会定期学術集会 2024.4.20
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Event date： 2024.4.18 - 2024.4.20
Language：Japanese Presentation type：Oral presentation (general)
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外科と救急のダブルボード取得を目指した外科救急連携コース
黒田新士, 安井和也, 岡﨑幹生, 小谷恭弘, 枝園忠彦, 小林純子, 中尾篤典, 笠原真悟, 豊岡伸一, 藤原俊義
第124回日本外科学会定期学術集会 2024.4.20
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Event date： 2024.4.18 - 2024.4.20
Language：Japanese Presentation type：Oral presentation (invited, special)
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完全房室中隔欠損症に対するmodified single patch法の再手術回避率―心室中隔欠損症の解析からの再考察―
笠原真悟, 小林泰幸, 小林純子, 川畑拓也, 黒子洋介, 小谷恭弘
第124回日本外科学会定期学術集会 2024.4.19
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Event date： 2024.4.18 - 2024.4.20
Language：Japanese Presentation type：Symposium, workshop panel (nominated)
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成人先天性心疾患領域における三尖弁形成術
徳田雄平, 小谷恭弘, 倉田裕次, 森岡 慧, 成宮悠仁, 岸 良匡, 鈴木浩之, 枝木大治, 小松弘明, 井上善紀, 小林純子, 藤井泰宏, 川畑拓也, 黒子洋介, 加藤源太郎, 笠原真悟
第38回日本小児循環器学会 近畿・中四国地方会 2024.3.3
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完全大血管転位症のJatene手術後に生じた三尖弁逆流に対する外科治療
岸 良匡, 黒子洋介, 徳田雄平, 倉田裕次, 森岡 慧, 成宮悠仁, 鈴木浩之, 井上善紀, 枝木大治, 小松弘明, 小林純子, 藤井泰宏, 川畑拓也, 小谷恭弘, 加藤源太郎, 笠原真悟
第38回日本小児循環器学会 近畿・中四国地方会 2024.3.3
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乳児単心室症に対し、異種心膜を使用した大動脈の三弁尖置換術の一例
井上善紀, 小谷恭弘, 倉田裕次, 徳田雄平, 森岡 慧, 成宮悠仁, 岸 良匡, 鈴木浩之, 枝木大治, 小松弘明, 藤井泰宏, 小林純子, 黒子洋介, 加藤源太郎, 笠原真悟
第10回自己心膜等による大動脈弁再建術学会 2024.2.24
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TPVI時代におけるファロー四徴症に対する心内修復時の右室流出路再建を再考する
堀川優衣, 小谷恭弘, 佐野俊和, 堀尾直裕, 宮原義典, 小林純子, 川畑拓也, 黒子洋介, 佐野俊二, 笠原真悟
第54回日本心臓血管外科学会学術総会 2024.2.22
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Event date： 2024.2.22 - 2024.2.24
Language：Japanese Presentation type：Symposium, workshop panel (public)
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先天性心疾患術後冠動脈狭窄に対する外科的介入5例の経験
井上善紀, 杭ノ瀬慶彦, 武田直人, 三浦 望, 森岡 慧, 鈴木浩之, 成宮悠仁, 岸 良匡, 枝木大治, 小松弘明, 小林純子, 藤井泰宏, 川畑拓也, 加藤源太郎, 黒子洋介, 小谷恭弘, 笠原真悟
第54回日本心臓血管外科学会学術総会 2024.2.22
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Event date： 2024.2.22 - 2024.2.24
Language：Japanese Presentation type：Poster presentation
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腹部大動脈人工血管置換術における中枢側Inclusion法による吻合の耐久性
藤井泰宏, 笠原真悟, 小谷恭弘, 加藤源太郎, 黒子洋介, 川畑拓也, 大澤 晋, 小林純子
第54回日本心臓血管外科学会学術総会 2024.2.22
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Event date： 2024.2.22 - 2024.2.24
Language：Japanese Presentation type：Poster presentation
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当院における無脾症候群を合併した単心室症例の治療成績の検討
小林純子, 森岡 慧, 成宮悠仁, 岸 良匡, 井上善紀, 鈴木浩之, 枝木大治, 小松弘明, 藤井泰宏, 川畑拓也, 加藤源太郎, 黒子洋介, 小谷恭弘, 笠原真悟
第54回日本心臓血管外科学会学術総会 2024.2.22
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Event date： 2024.2.22 - 2024.2.24
Language：Japanese Presentation type：Symposium, workshop panel (public)
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Short-term Outcomes of Adjustable Annular Bridging Technique for Common Atrioventricular Valve Regurgitation in Patients with Single
Suzuki H., Kotani Y., Kobayashi J., Fujii Y., Kawabata T., Kato G., Kuroko Y., Kasahara S.
The 60th Annual Meeting of The Society of Thoracic Surgeons 2024.1.27
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Event date： 2024.1.27 - 2024.1.29
Language：English Presentation type：Poster presentation
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TOF術後遠隔期に大動脈基部拡大および大動脈弁逆流のためCabrol法にてBentall手術を行った1例
黒子洋介, 小林純子, 小谷恭弘, 笠原真悟
第1回成人先天性心疾患（ACHD）手術手技研究会 2024.1.7
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Event date： 2024.1.7
Language：Japanese Presentation type：Symposium, workshop panel (public)
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成人期における修正大血管転位症患者の臨床像
小谷恭弘, 杜 徳尚, 黒子洋介, 小林純子, 川畑拓也, 馬場健児, 赤木禎治, 笠原真悟
第25回日本成人先天性心疾患学会総会・学術集会 2024.1.6
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Event date： 2024.1.6 - 2024.1.8
Language：Japanese Presentation type：Oral presentation (general)
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A rescue two-leaflet reconstruction to the acute severe aortic insufficiency using Ozaki procedure in an infant
Kobayashi J, Kawabata T, Kuroko Y, Kotani Y, Kasahara S
Asia-Pacific cardiovascular Intervention & Surgery 2022 2022.11.11
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Event date： 2022.11.10 - 2022.11.11
Language：English
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先天性心疾患手術：アジアから世界へ（ディスカッサント）
小林 純子
第75回日本胸部外科学会定期学術集会 2022.10.7
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Event date： 2022.10.5 - 2022.10.8
Language：English
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Bidirectional Glenn手術時にadditional flowを残すことでFontanの成績は改善するか？当院のBidirectional GlennおよびFontan手術の中長期成績と危険因子の検討
小林純子、川畑拓也、黒子洋介、小谷恭弘、笠原真悟
第58回日本小児循環器学会総会・学術集会 2022.7.23
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Event date： 2022.7.21 - 2022.7.23
Language：Japanese
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Long-term Outcomes and Predictors for the Mortality before Fontan Completion in Heterotaxy Syndrome with Single Ventricle Physiology
Kobayashi J, Kotani Y, Kawabata T, Eto K, Hirota M, Kuroko Y, Kasahara S
The 102nd Annual Meeting of American Association for Thoracic Surgery 2022.5.16
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Event date： 2022.5.14 - 2022.5.17
Language：English
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Who is the True Candidate of Fenestrated Fontan? Fate of Fenestration and the Long-term Outcomes after Fenestrated Fontan in the High-risk Patients
Kobayashi J, Kotani Y, Kuroko Y, Eto K, Kawabata T, Hirota M, Kasahara S
The 102nd Annual Meeting of American Association for Thoracic Surgery 2022.5.16
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Event date： 2022.5.14 - 2022.5.17
Language：English
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Long-term outcome of Fontan completion and the factors associated with interstage mortality in the patients with right isomerism
Kobayashi J, Kotani Y, Kawabata T, Eto K, Hirota M, Kuroko Y, Kasahara S
The 30th Annual Meeting of Asian Society for Cardiovascular and Thoracic Surgery 2022.3.26
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Event date： 2022.3.24 - 2022.3.27
Language：English
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海外留学（北米地域プレゼンター）
小林 純子
第86回日本循環器学会学術集会 2022.3.13
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Event date： 2022.3.11 - 2022.3.13
Language：Japanese
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Fenestrationの適応と効果は? 当院のselective fenestrated Fontanの中長期成績の検討
小林純子、鈴木浩之、枝木大治、木佐森永理、小松弘明、迫田直也、辻 龍典、横田 豊、村岡玄哉、衛藤弘城、川畑拓也、廣田真規、黒子洋介、小谷恭弘、笠原真悟
第52回日本心臓血管外科学会学術総会 2022.3.4
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Event date： 2022.3.3 - 2022.3.5
Language：Japanese
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当院におけるHeterotaxy syndromeの中長期成績の検討
小林純子、鈴木浩之、枝木大治、木佐森永理、小松弘明、迫田直也、辻 龍典、横田 豊、村岡玄哉、衛藤弘城、川畑拓也、廣田真規、黒子洋介、小谷恭弘、笠原真悟
第52回日本心臓血管外科学会学術総会 2022.3.3
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Event date： 2022.3.3 - 2022.3.5
Language：Japanese Presentation type：Symposium, workshop panel (public)
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A successful repair of the neonatal dysplastic tricuspid valve and pulmonary atresia.
Kobayashi J, Kawabata T, Kuroko Y, Kotani Y, Kasahara S
Asia-Pacific Cardiovascular Intervention and Surgery 2021.11.13
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Event date： 2021.11.11 - 2021.11.13
Language：English Presentation type：Oral presentation (general)
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Fontan術後の末梢肺動脈狭窄への治療戦略：まずはカテーテル治療を、他の心修復が必要なら積極的な外科手術を！
小林純子, 横山翔平, 鈴木浩之, 木佐森永理, 枝木大治, 小松弘明, 横田 豊, 辻 龍典, 小林泰幸, 迫田直也, 村岡玄哉, 衛藤弘城, 川畑拓也, 黒子洋介, 廣田真規, 小谷恭弘, 笠原真悟
第74回日本胸部外科学会定期学術集会 2021.11.3
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Event date： 2021.10.31 - 2021.11.3
Language：Japanese Presentation type：Symposium, workshop panel (public)
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Fenestration作成は予後を改善するか？当院におけるFontan手術の中長期成績と予後因子の検討
小林純子, 小谷恭弘, 川畑拓也, 黒子洋介, 笠原真悟
第57回日本小児循環器学会総会・学術集会 2021.7
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Event date： 2021.7.9 - 2021.7.11
Language：Japanese Presentation type：Oral presentation (general)
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左心低形成症候群に対する非定型的な大動脈弓再建
小林純子, 小谷恭弘, 木佐森永理, 小松弘明, 辻 龍典, 迫田直也, 小林泰幸, 横田 豊, 村岡玄哉, 堀尾直裕, 川畑拓也, 廣田真規, 黒子洋介, 笠原真悟
第64回関西胸部外科学会学術集会 2021.6
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Event date： 2021.6.17 - 2021.6.19
Language：Japanese Presentation type：Oral presentation (general)
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Survival and re-intervention following elective versus rescue coronary ostioplasty for congenital heart disease
Kobayashi J, Chetan D, Varenbut J, Luo S, Haller C, Runeckles K, Steve Fan CP, Van Arsdell GS, Barron DJ, Honjo O
Congenital Heart Surgeons Society and European Congenital Heart Surgeons Association Joint meeting 2020 2020.10
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Event date： 2020.10.24 - 2020.10.25
Language：English Presentation type：Oral presentation (general)
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Flow vs. pressure-targeted ex-vivo heart perfusion for infantile donors of donation after cardiac death in piglet model
Kobayashi J, Luo S, Haranal M, Akazawa Y, Parker M, Wang J, Varenbut J, Moss K, Deng MX, Friedberg MK, Haller C, Honjo O
American Association for Thoracic Surgery 99th annual meeting 2019.5
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Event date： 2019.5.4 - 2019.5.7
Language：English Presentation type：Oral presentation (general)
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Pressure-targeted perfusion is the optimal strategy of the pediatric ex-vivo heart perfusion for donation after cardiac death in porcine model
Kobayashi J, Luo S, Haranal M, Parker M, Wang J, Haller C, Honjo O
Canadian Cardiovascular Congress 2018 2018.10
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Event date： 2018.10.20 - 2018.10.23
Language：English Presentation type：Poster presentation
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Pressure-targeted ex-vivo heart perfusion is the optimal strategy for donation after cardiac death of infants
Kobayashi J, Luo S, Haranal M, Parker M, Wang J, Haller C, Honjo O
Heart Failure Update 2018 2018.5
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Event date： 2018.5.11 - 2018.5.12
Language：English Presentation type：Poster presentation
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Pressure-targeted perfusion is the optimal strategy of the ex-vivo heart perfusion for donation after cardiac death in juvenile pig model
Kobayashi J, Luo S, Parker M, Wang J, Haller C, Honjo O
44th Gallie Day 2018.5.11
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Development of the new ex-vivo heart perfusion therapy for infants
Kobayashi J, Luo S, Parker M, Wang J, Haller C, Honjo O
Annual Cardiovascular Scientific Day of Heart & Stroke / Richard Lewar Centre of Excellence 2018.4.11
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The pressure-targeted strategy is the key for the successful ex-vivo perfusion model for infants
Kobayashi J, Luo S, Parker M, Wang J, Haller C, Honjo O
Annual Cardiovascular Scientific Day of Heart & Stroke / Richard Lewar Centre of Excellence 2018.4.11
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Modified Blalock-Taussig shunt術後成績の検討
川田幸子, 小谷恭弘, 村岡玄哉, 小林泰幸, 掘尾直裕, 後藤拓弥, 小林純子, 佐野俊和, 衛藤弘城, 奥山倫弘, 増田善逸, 黒子洋介, 新井禎彦, 笠原真悟
第70回日本胸部外科学会定期学術集会 2017.9
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Event date： 2017.9.26 - 2017.9.29
Language：Japanese Presentation type：Poster presentation
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大動脈縮窄症についての数値流体力学的検討
掘尾直裕, 笠原真悟, 川田幸子, 衛藤弘城, 小林純子, 藤井泰宏, 黒子洋介, 小谷恭弘, 増田善逸, 新井禎彦
第70回日本胸部外科学会定期学術集会 2017.9
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中心肺動脈の形態からみたPAVSD with MAPCA の外科治療成績
小谷恭弘, 新井禎彦, 黒子洋介, 小林純子, 掘尾直裕, 川田幸子, 小林泰幸, 村岡玄哉, 佐野俊二, 笠原真悟
第 2017.9
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単心室症における自己心臓内幹細胞治療の臨床と先天性心疾患におけるiPS細胞の研究の現況と展望
新井禎彦, 石神修大, 小林純子, 後藤拓弥, 佐野俊和, 大月審一, 王 英正, 小谷恭弘, 黒子洋介, 笠原真悟, 佐野俊二
第53回日本小児循環器学会総会・学術集会 2017.7
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Fontan手術到達例から見たAsplenia syndromeの外科治療の成績
笠原真悟, 井上善紀, 川田幸子, 佐野俊和, 掘尾直裕, 小林純子, 石神修大, 藤井泰宏, 黒子洋介, 小谷恭弘, 新井禎彦
第53回日本小児循環器学会総会・学術集会 2017.7
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左冠動脈大動脈起始22例における長期成績の検討
川田幸子, 小谷恭弘, 岸 良匡, 枝木大治, 小林泰幸, 衛藤弘城, 石神修大, 後藤拓弥, 奥山倫弘, 小林純子, 藤井泰宏, 新井禎彦, 笠原真悟, 佐野俊二
第47回日本心臓血管外科学会学術総会 2017.2
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左側開胸で外傷性左室中隔仮性瘤にアプローチした一例
岸 良匡, 小谷恭弘, 川田幸子, 枝木大治, 小林泰幸, 衛藤弘城, 堀尾直裕, 石神修大, 後藤拓弥, 奥山倫弘, 小林純子, 藤井泰宏, 新井禎彦, 笠原真悟, 佐野俊二
第47回日本心臓血管外科学会学術総会 2017.2
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右側大動脈弓を合併した左心低形成症候群に対する大動脈再建の2例
小林 純子, 小谷 恭弘, 笠原 真悟, 堀尾 直裕, 黒子 洋介, 増田 善逸, 新井 禎彦, 佐野 俊二
第46回日本心臓血管外科学会学術総会 2016.2
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Event date： 2016.2.15 - 2016.2.17
Language：Japanese Presentation type：Poster presentation
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疾患特異的iPS細胞による新たな先天性心疾患モデルの作成
小林 純子, 吉田 賢司, 樽井 俊, 永井 祐介, 笠原 真悟, 成瀬恵治, 伊藤 浩, 佐野 俊二, 王 英正
第51回日本小児循環器学会総会・学術集会 2015.7
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Event date： 2015.7.16 - 2015.7.18
Language：Japanese Presentation type：Symposium, workshop panel (public)
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出産後も心臓血管外科研修を継続するための要件とは何か ～育児中に学位取得、心臓外科研修をして考えたこと～
小林 純子, 樽井 俊, 藤井 泰宏, 小谷 恭弘, 川畑 拓也, 黒子 洋介, 吉積 功, 新井 禎彦, 笠原 真悟, 王 英正, 佐野 俊二
第51回日本小児循環器学会総会・学術集会 2015.7
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Event date： 2015.7.16 - 2015.7.18
Language：Japanese Presentation type：Symposium, workshop panel (public)
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Patient-specific induced pluripotent stem cells identify the transcriptional repression and epigenetic modification of NKX2-5, HAND1, and NOTCH1 during cardiac development of hypoplastic left heart syndrome
Kobayashi J, Yoshida M, Tarui S, Ishigami S, Okuyama M, Nagai Y, Kasahara S, Naruse K, Ito H, Sano S, Oh H
Okayama-KU Joint Symposium for New Therapeutic strategy in Neuronal Diseases 2015.1.28
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Epigenetic and transcriptional regulation of induced pluripotent stem cells in patients with hypoplastic left heart syndrome
Kobayashi J, Yoshida M, Tarui S, Ishigami S, Okuyama M, Nagai Y, Kasahara S, Naruse K, Ito H, Sano S, Oh H
Scientific Sessions 2014 of American Heart Association 2014.11
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Event date： 2014.11.14 - 2014.11.19
Language：English Presentation type：Poster presentation
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NKX2-5, HAND1, and NOTCH1 regulate the cardiogenesis of hypoplastic left heart syndrome
Kobayashi J, Yoshida M, Tarui S, Ishigami S, Okuyama M, Nagai Y, Kasahara S, Naruse K, Ito H, Sano S, Oh H
Scientific Sessions 2014 of American Heart Association 2014.11
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Event date： 2014.11.14 - 2014.11.19
Language：English Presentation type：Poster presentation
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Unique epigenetic and transcriptional regulation of induced pluripotent stem cells in patients with hypoplastic left heart syndrome
Kobayashi J, Yoshida M, Tarui S, Ishigami S, Okuyama M, Nagai Y, Kasahara S, Naruse K, Ito H, Sano S, Oh H
Congress 2014 of European Society of Cardiology 2014.9
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Event date： 2014.8.31 - 2014.9.3
Language：English Presentation type：Oral presentation (general)
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Epigenetic and transcriptional regulation of induced pluripotent stem cells in patients with hypoplastic left heart syndrome
Kobayashi J, Yoshida M, Tarui S, Ishigami S, Okuyama M, Nagai Y, Kasahara S, Naruse K, Ito H, Sano S, Oh H
Basic Cardiovascular Sciences 2014 Scientific Sessions 2014.7
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Event date： 2014.7.14 - 2014.7.17
Language：English Presentation type：Poster presentation
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NKX2-5, HAND1, and NOTCH1 regulate the cardiac development of iPS cells in patients with HLHS
Kobayashi J, Yoshida M, Tarui S, Ishigami S, Okuyama M, Nagai Y, Kasahara S, Naruse K, Ito H, Sano S, Oh H
The 10th Japan-China-Korea Pediatric Heart Forum 2014.7
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Event date： 2014.7.4 - 2014.7.5
Language：English Presentation type：Oral presentation (general)
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iPS細胞を用いた左心低形成症候群における疾患発症機序の解明
小林純子, 吉田 賢司, 樽井 俊, 石神修大, 奥山倫弘, 永井祐介, 笠原真悟, 成瀬恵治, 伊藤 浩, 佐野俊二, 王 英正
第50回日本小児循環器学会総会・学術集会 2014.7
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Event date： 2014.7.3 - 2014.7.5
Language：Japanese Presentation type：Symposium, workshop panel (public)
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Altered epigenetic and transcriptional regulation of induced pluripotent stem cells in patients with hypoplastic left heart syndrome
Junko Kobayashi, Masashi Yoshida, Suguru Tarui, Shuta Ishigami, Michihiro Okuyama, Yusuke Nagai, Shingo Kasahara, Keiji Naruse, Hiroshi Ito, Shunji Sano, Hidemasa Oh
International society for stem cell research 12th annual meeting 2014.6
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Event date： 2014.6.18 - 2014.6.21
Language：English Presentation type：Poster presentation
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Assessment of genetic and epigenetic modifications in hypoplatic left heart syndrome by disease-specific iPS cells
Junko Kobayashi, Masashi Yoshida, Suguru Tarui, Yusuke Nagai, Shingo Kasahara, Keiji Naruse, Hiroshi Ito, Shunji Sano, Hidemasa Oh
第78回日本循環器学会学術集会 2014.3
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Event date： 2014.3.21 - 2014.3.23
Language：English Presentation type：Oral presentation (general)
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患者由来iPS細胞を用いた左心低形成症候群における疾患発症機序の解明
小林純子, 吉田賢司, 樽井 俊, 永井祐介, 笠原真悟, 成瀬恵治, 伊藤 浩, 佐野俊二, 王 英正
第13回日本再生医療学会総会 2014.3
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Directed differentiation of patient-specific induced pluripotent stem cells identifies the cardiac transcriptional repression during myocardial growth and patterning in hypoplastic left heart syndromeScientific Sessions 2013 of American Heart Association
Kobayashi J, Yoshida M, Tarui S, Hirata S, Nagai Y, Kasahara S, Naruse K, Ito H, Sano S, Oh H
Scientific Sessions 2013 of American Heart Association 2013.11
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Event date： 2013.11.16 - 2013.11.20
Language：English Presentation type：Poster presentation
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Lineage induction of patient-specific iPS cells identifies the cardiac transcriptional repression during myocardial growth and patterning in hypoplastic left heart syndrome
Kobayashi J, Yoshida M, Tarui S, Hirata S, Nagai Y, Kasahara S, Naruse K, Ito H, Sano S, Oh H
the 7th TAKAO international symposium on etiology and morphogenesis of congenital heart disease 2013.7
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Event date： 2013.7.13 - 2013.7.15
Language：English Presentation type：Poster presentation
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疾患特異的iPS細胞を用いた左心低形成症候群における心臓発生異常の解明
小林純子, 樽井 俊, 平田昌敬, 川畑拓也, 黒子洋介, 立石篤史, 吉積 功, 新井禎彦, 笠原真悟, 佐野俊二, 王 英正
第113回日本外科学会定期学術集会 2013.4
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Event date： 2013.4.11 - 2013.4.13
Language：Japanese Presentation type：Oral presentation (general)
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Patient-specific induced pluripotent stem cells recapitulate the models of hypoplastic left heart syndrome
Junko Kobayashi, Masashi Yoshida, Suguru Tarui, Masataka Hirata, Ken Takahashi, Shingo Kasahara, Keiji Naruse, Hiroshi Ito, Shunji Sano, Hidemasa Oh
The 21st annual meeting of the Asian society for cardiovascular and thoracic surgery 2013.4
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Event date： 2013.4.4 - 2013.4.7
Language：English Presentation type：Oral presentation (general)
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Modeling and dissecting hypoplastic left heart syndrome by patient-specific induced pluripotent stem cells
Junko Kobayashi, Masashi Yoshida, Suguru Tarui, Masataka Hirata, Yusuke Nagai, Ken Takahashi, Shingo Kasahara, Keiji Naruse, Hiroshi Ito, Shunji Sano, Hidemasa Oh
第77回日本循環器学会学術集会 2013.3
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Event date： 2013.3.15 - 2013.3.17
Language：English Presentation type：Oral presentation (general)
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先天性心疾患の疾患特異的iPS細胞の樹立と左心低形成症候群の心臓発生異常の解明
小林純子, 樽井 俊, 平田昌敬, 川畑拓也, 黒子洋介, 立石篤史, 吉積 功, 新井禎彦, 笠原真悟, 佐野俊二, 王 英正
第43回日本心臓血管外科学会学術総会 2013.2
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Event date： 2013.2.24 - 2013.2.27
Language：Japanese Presentation type：Oral presentation (general)
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Patient-specific induced pluripotent stem cells for modeling hypoplastic left heart syndrome
Kobayashi J, Yoshida M, Tarui S, Hirata S, Takahashi K, Kasahara S, Naruse K, Ito H, Sano S, Oh H
Scientific Sessions 2012 of American Heart Association 2012.11
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Event date： 2012.11.3 - 2012.11.7
Language：English Presentation type：Oral presentation (general)
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疾患特異的iPS細胞を用いた左心低形成症候群における心臓発生異常の解明
小林純子, 樽井 俊, 田昌, 畑拓, 子洋介, 石篤史, 吉積, 原真, 野俊二
第65回日本胸部外科学会定期学術集会 2012.10
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Event date： 2012.10.17 - 2012.10.20
Language：Japanese Presentation type：Oral presentation (general)
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Patient-specific induced pluripotent stem cells from cardiac progenitors recapitulate the models for cardiac chamber disorders
Kobayashi J, Yoshida M, Tarui S, Hirata S, Takahashi K, Kasahara S, Naruse K, Sano S, Oh H
Congress 2012 of European society of Cardiology 2012.8
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Event date： 2012.8.25 - 2012.8.29
Language：English Presentation type：Oral presentation (general)
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先天性心疾患患者由来の心臓内幹細胞を用いた疾患特異的ヒトiPS細胞の樹立と機能解析
小林純子, 樽井 俊, 田昌, 畑拓也, 子洋介, 石篤史, 吉積, 井禎, 原真悟, 佐野俊二, 王 英正
第48回日本小児循環器学会総会・学術集会 2012.7
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Event date： 2012.7.5 - 2012.7.7
Language：Japanese Presentation type：Oral presentation (general)
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Patient-specific induced pluripotent stem cells from cardiac progenitors recapitulate the models for cardiac chamber disorders
Kobayashi J, Yoshida M, Tarui S, Hirata S, Takahashi K, Kasahara S, Naruse K, Sano S, Oh H
10th Annual Meeting of International Society for Stem Cell Research 2012.6
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Event date： 2012.6.13 - 2012.6.16
Language：English Presentation type：Poster presentation
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Reprogramming of human cardiac progenitors into pluripotency in patients with congenital heart diseases
Kobayashi J, Yoshida M, Tarui S, Hirata S, Tateishi A, Arai S, Kasahara S, Ito H, Sano S, Oh H
第76回日本循環器学会学術集会 2012.3
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Event date： 2012.3.16 - 2012.3.18
Language：English Presentation type：Poster presentation
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先天性心疾患由来のヒト人工的多能性幹(iPS)細胞の樹立と機能解析
小林 純子, 樽井 俊, 平田 昌敬, 立石 篤史, 新井 禎彦, 笠原 真悟, 佐野 俊二, 王 英正
第64回日本胸部外科学会定期学術集会 2011.10
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Event date： 2011.10.9 - 2011.10.12
Language：Japanese Presentation type：Oral presentation (general)
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I型VSDに対する右腋窩縦切開でのtransaortic approachによる閉鎖術
小谷恭弘, 川畑拓也, 黒子洋介, 小林純子, 笠原真悟
第1回CHSS Japan手術手技研究会 2020.11.22
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Awards
Awards
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優秀演題賞
2023.12 第85回 日本臨床外科学会総会
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Furuse Award
2022.3 Asian Society for Cardiovascular and Thoracic Surgery Long-term outcome of Fontan completion and the factors associated with interstage mortality in the patients with right isomerism
Junko Kobayashi
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Award type：Award from international society, conference, symposium, etc.
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the John A. Hawkins Top Scoring Abstract Award
2020.10 Congenital Heart Surgeons Society and European Congenital Heart Surgeons Association Joint meeting
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Finalist for the 22nd Annual C. Walton Lillehei Resident Competition
2019.5 American association for thoracic surgery
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Winner of the Dragon’s Den pitch of Clinical stream
2018.4 Heart & Stroke / Richard Lewar Centre of Excellence, University of Toronto
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Best of AHA Specialty Conferences
2014.11 American Heart Association
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Young Investigators Awards on Basic Science
2014.8 European Society of Cardiology
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Young Researcher Award
2013.4 日本外科学会
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心臓血管外科賞
2013.3 日本循環器学会
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会長賞
2012.7 日本小児循環器学会
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優秀演題賞
2011.10 日本胸部外科学会
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Research Projects
Research Projects
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22q11.2欠失症候群との網羅的な比較検討によるファロー四徴症での遺伝子異常の解明
Grant number：23K08237 2023.04 - 2026.03
日本学術振興会 科学研究費助成事業 基盤研究(C)
鈴木 浩之, 小林 純子
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ファロー四徴症における右室流出路狭窄の病態発生機序の解明と予後予測マーカーの開発
Grant number：21K16497 2021.04 - 2024.03
日本学術振興会 科学研究費助成事業 若手研究 若手研究
小林 純子
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Grant amount：\4680000 （ Direct expense: \3600000 、 Indirect expense：\1080000 ）
ファロー四徴症は最も発生頻度の高いチアノーゼ性先天性心疾患である。本疾患の予後は右室流出路狭窄および逆流から生じる右心不全に左右され、個々の症例で経過は大きく異なる。しかし本疾患は未だ原因不明であり治療法は確立されておらず、本邦の指定難病とされている。特に、遠隔期の問題である右心不全とその治療法については、多くが未知の状態である。
本研究では、ファロー四徴症の病態の中心となる右室流出路狭窄について、その病態発生メカニズムの解明および予後を予測するマーカーの開発を行う。これまで、我々は先天性心疾患患者から手術中に心臓組織検体を採取し、その組織検体の解析および心臓前駆細胞（Cardiac progenitor cells: CPCs）を精製・分離・培養し解析する技術を確立してきた。これまでに培った技術を用いて、本研究では当院で心臓手術を施行するファロー四徴症および類縁疾患患者から手術中に心臓組織検体を採取し、組織検体の遺伝子変異および遺伝子発現解析を行い、またCPCsを精製・分離・培養を行い解析する。
本研究は患者検体を使用する研究であり、岡山大学病院倫理委員会に研究計画書を提出し、承認を得てから研究を開始する。そして、当院で当該手術を行う患者に対し研究について承認された様式に従って十分な説明をし、同意を得てから手術中に心臓組織検体の採取を行う。患者の個人情報は匿名化して管理し、その取り扱いには十分に配慮を行う。
令和3年度の研究実績は、研究費取得確認後に研究計画書を岡山大学病院倫理委員会に提出し、承認された（申請番号：研2111-030）。研究計画承認後、術中の心臓検体採取および細胞培養開始のための最終準備を行い、岡山大学病院倫理委員会の所定の様式に従い研究同意を得たうえで、患者心臓組織検体の採取および細胞培養を開始した。
Class subject in charge
Class subject in charge
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Practicals: Cardiovascular Surgery （2024academic year） special - その他
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Research Projects: Cardiovascular Surgery （2024academic year） special - その他
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Cardiovascular Surgery (Core Clinical Practice) （2024academic year） special - その他
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Research Projects and Practicals: Cardiovascular Surgery I （2024academic year） special - その他
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Lecture and Research Projects: Cardiovascular Surgery I （2024academic year） special - その他
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Research Projects and Practicals: Cardiovascular Surgery II （2024academic year） special - その他
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Lecture and Research Projects: Cardiovascular Surgery II （2024academic year） special - その他
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Practicals: Cardiovascular Surgery （2023academic year） special - その他
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Research Projects: Cardiovascular Surgery （2023academic year） special - その他
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Cardiovascular Surgery (Core Clinical Practice) （2023academic year） special - その他
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Research Projects and Practicals: Cardiovascular Surgery I （2023academic year） special - その他
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Lecture and Research Projects: Cardiovascular Surgery I （2023academic year） special - その他
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Research Projects and Practicals: Cardiovascular Surgery II （2023academic year） special - その他
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Lecture and Research Projects: Cardiovascular Surgery II （2023academic year） special - その他
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医学研究インターンシップ （2022academic year） ３・４学期
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外科学II （2022academic year） 第４学期
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循環器系（臓器・系別統合講義） （2022academic year） 特別
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Cardiovascular Surgery (Core Clinical Practice) （2022academic year） special - その他
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心臓血管外科学（選択制臨床実習） （2022academic year） 特別
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Research Projects and Practicals: Cardiovascular Surgery I （2022academic year） special - その他
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Lecture and Research Projects: Cardiovascular Surgery I （2022academic year） special - その他
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Research Projects and Practicals: Cardiovascular Surgery II （2022academic year） special - その他
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Lecture and Research Projects: Cardiovascular Surgery II （2022academic year） special - その他
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医学研究インターンシップ （2021academic year） ３・４学期
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外科学II （2021academic year） 第４学期
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循環器系（臓器・系別統合講義） （2021academic year） 特別
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Cardiovascular Surgery (Core Clinical Practice) （2021academic year） special - その他
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心臓血管外科学（選択制臨床実習） （2021academic year） 特別
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Research Projects and Practicals: Cardiovascular Surgery I （2021academic year） special - その他
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Lecture and Research Projects: Cardiovascular Surgery I （2021academic year） special - その他
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Research Projects and Practicals: Cardiovascular Surgery II （2021academic year） special - その他
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Lecture and Research Projects: Cardiovascular Surgery II （2021academic year） special - その他
Media Coverage
Media Coverage
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M's story 難手術の先に子どもたちの笑顔 岡山大学病院心臓血管外科助教 小林純子（42） Newspaper, magazine
山陽新聞 2023.6
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医局紹介 岡山大学学術研究院 医歯薬学域 心臓血管外科 Newspaper, magazine
ドクターズマガジン 2022.6
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単心室症関与遺伝子を特定 Newspaper, magazine
山陽新聞 2012.10
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