Updated on 2025/02/20

写真a

 
Junko Kobayashi
 
Organization
Faculty of Medicine, Dentistry and Pharmaceutical Sciences Assistant Professor
Position
Assistant Professor
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Degree

  • Doctor of Philosophy in Medical Science ( 2014.12   Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences )

Research Interests

  • Congenital heart disease

  • Cardiovascular Surgery

Research Areas

  • Life Science / Cardiovascular surgery  / Congenital heart disease

Education

  • 岡山大学大学院   医歯薬学総合研究科  

    2009.4 - 2014.12

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  • Tottori University   医学部医学科  

    1999.4 - 2005.3

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Research History

  • 岡山大学学術研究院 医歯薬学域   助教

    2024.4

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  • 岡山大学病院   助教

    2021.1 - 2024.3

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  • 岡山大学病院   医員

    2020.8 - 2020.12

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  • カナダ トロント小児病院   クリニカルフェロー

    2019.1 - 2020.6

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  • カナダ トロント小児病院   リサーチフェロー

    2017.9 - 2018.12

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Professional Memberships

  • The Asian Society for Cardiovascular and Thoracic Surgery

    2022

  • 日本心臓血管外科学会

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  • 日本外科学会

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  • 日本循環器学会

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  • 日本胸部外科学会

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Committee Memberships

  • 岡山大学病院   身体的拘束最小化チーム運営委員会  

    2024.11   

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  • 岡山大学   感染制御部職員会議  

    2024.4   

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  • 日本外科学会   代議員  

    2024.1   

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  • 日本外科学会   ダイバーシティ推進委員  

    2024.1   

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  • 岡山大学   ペイシェントセーフティマネジャー会議  

    2024.1   

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Papers

  • When to intervene the pulmonary artery: Importance of anatomical assessment in the diagnosis of pulmonary artery coarctation. Reviewed International journal

    Eiri Kisamori, Yasuhiro Kotani, Hiroyuki Suzuki, Junko Kobayashi, Takuya Kawabata, Yosuke Kuroko, Shingo Kasahara

    The Journal of thoracic and cardiovascular surgery   166 ( 3 )   926 - 932   2023.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVE: Pulmonary artery coarctation (PACoA) is a major problem that increases the frequency of intervention. However, there is little evidence regarding the prediction of PACoA development. METHODS: A retrospective chart review was performed on 42 patients who underwent modified Blalock-Taussig shunt and preoperative contrast-enhanced computed tomography. An uneven PA branching was defined as an abnormal ductus arteriosus connection to the left PA distal to the PA branching on contrast-enhanced computed tomography. RESULTS: Nineteen (45.2%) of 42 patients were diagnosed with PACoA. The median diameters of the ductus on the aorta and PA sides were 4.1 mm and 3.6 mm in the PACoA group and 3.6 mm and 2.9 mm in the non-PACoA group, respectively (P = .07 and .28, respectively). Tortuous ductus was recognized in 7 (36.8%) patients in the PACoA group and 14 (60.8%) patients in the non-PACoA group (P = .12). PACoA was associated with pulmonary atresia (16 patients [84.2%] in the PACoA group and 12 patients [52.1%] in the non-PACoA group) (P = .02). All 19 patients had uneven PA branching in the PACoA group, whereas 5 of 23 (21.7%) patients had uneven PA branching in the non-PACoA group (P < .001). CONCLUSIONS: Uneven PA branching rather than the ductus arteriosus size was strongly associated with PACoA development; therefore, morphologic assessment by contrast-enhanced computed tomography should be considered in patients with pulmonary atresia.

    DOI: 10.1016/j.jtcvs.2023.02.021

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  • Cardioprotective Actions of a Glucagon‐like Peptide‐1 Receptor Agonist on Hearts Donated After Circulatory Death Reviewed

    Sachiko Kadowaki, M. Ahsan Siraj, Weiden Chen, Jian Wang, Marlee Parker, Anita Nagy, Chun‐Po Steve Fan, Kyle Runeckles, Jing Li, Junko Kobayashi, Christoph Haller, Mansoor Husain, Osami Honjo

    Journal of the American Heart Association   12 ( 3 )   2023.2

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Ovid Technologies (Wolters Kluwer Health)  

    Background

    <p lang="en">Heart transplantation with a donation after circulatory death (DCD) heart is complicated by substantial organ ischemia and ischemia–reperfusion injury. Exenatide, a glucagon‐like peptide−1 receptor agonist, manifests protection against cardiac ischemia–reperfusion injury in other settings. Here we evaluate the effects of exenatide on DCD hearts in juvenile pigs.

    </p> Methods and Results

    <p lang="en"> DCD hearts with 15‐minutes of global warm ischemia after circulatory arrest were reperfused ex vivo and switched to working mode. Treatment with concentration 5‐nmol exenatide was given during reperfusion. DCD hearts treated with exenatide showed higher myocardial oxygen consumption (exenatide [n=7] versus controls [n=7], over 60–120 minutes of reperfusion, P &lt;0.001) and lower cardiac troponin‐I release (27.94±11.17 versus 42.25±11.80 mmol/L, P =0.04) during reperfusion compared with controls. In working mode, exenatide‐treated hearts showed better diastolic function (dp/dt min: −3644±620 versus −2193±610 mm Hg/s, P &lt;0.001; Tau: 15.62±1.78 versus 24.59±7.35 milliseconds, P =0.02; lateral e ′ velocity: 11.27 ± 1.46 versus 7.19±2.96, P =0.01), as well as lower venous lactate levels (3.17±0.75 versus 5.17±1.44 mmol/L, P =0.01) compared with controls. Higher levels of activated endothelial nitric oxide synthase (phosphorylated to total endothelial nitric oxide synthase levels: 2.71±1.16 versus 1.37±0.35, P =0.02) with less histological evidence of endothelial damage (von Willebrand factor expression: 0.024±0.007 versus 0.331±0.302, pixel/μm, P =0.04) was also observed with exenatide treatment versus controls.

    </p> Conclusions

    <p lang="en">Acute treatment of DCD hearts with exenatide limits myocardial and endothelial injury and improves donor cardiac function.

    </p>

    DOI: 10.1161/jaha.122.027163

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  • Strategy of delayed repair of total anomalous pulmonary venous connection in right atrial isomerism and functional single ventricle. Reviewed International journal

    Eiri Kisamori, Yasuhiro Kotani, Fiza Komel Raja, Junko Kobayashi, Yosuke Kuroko, Takuya Kawabata, Shingo Kasahara

    JTCVS open   10   308 - 319   2022.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVE: Repair of total anomalous pulmonary venous connection (TAPVC) in neonates with right atrial isomerism and functional single ventricle is challenging. In our novel strategy, primary draining vein stenting (DVS) was applied to patients with preoperative pulmonary vein obstruction to delay TAPVC repair. This study investigated our initial experience with a strategy of delayed TAPVC repair, incorporating DVS. METHODS: Twenty-nine patients with right atrial isomerism and functional single ventricle who had a severe obstruction in the course of draining veins, who required surgical or catheter intervention in their neonatal period were retrospectively reviewed (primary DVS: n = 11; primary TAPVC repair: n = 18). RESULTS: Patients in the primary DVS group had more mixed type TAPVC (primary DVS: n = 5, 45.5%; primary TAPVC repair: n = 2, 11.1%; P = .03) and required more systemic to pulmonary shunt surgeries during their lifetime (primary DVS: n = 9, 81.8%; primary TAPVC repair: n = 6, 33.3%; P = .047). Kaplan-Meier analysis showed that primary DVS repair was associated with improved survival compared with primary TAPVC repair (survival rates at 90 days, 1 year, 3 years and 5 years: primary DVS: 100%, 80%, 68.6%, and 54.9%; primary TAPVC repair: 55.6%, 38.9%, 38.9%, and 38.9%, respectively [P = .04]). Of the 4 patients who underwent stenting of the ductus venosus, 3 had elevated liver enzymes after surgical repair of TAPVC due to ductus venosus steal, which markedly improved after coil embolization of the stent. CONCLUSIONS: For neonates with obstructive TAPVC and functional single ventricle, our delayed TAPVC repair using primary DVS appeared to improve survival compared with the conventional strategy.

    DOI: 10.1016/j.xjon.2021.11.012

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  • Technical modification and safe explantation of the Melody valve in the mitral position in small children Reviewed

    Junko Kobayashi, Juan Contreras, Devin Chetan, Osami Honjo

    JTCVS Techniques   13   209 - 210   2022.6

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.xjtc.2022.04.005

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  • Impact of pulmonary artery coarctation on pulmonary artery growth and definitive repair following modified Blalock-Taussig shunt. Reviewed International journal

    Yasuhiro Kotani, Yasuyuki Kobayashi, Sachiko Kadowaki, Eiri Kisamori, Junko Kobayashi, Takuya Kawabata, Yosuke Kuroko, Shingo Kasahara

    The Journal of thoracic and cardiovascular surgery   163 ( 5 )   1618 - 1626   2022.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVE: Pulmonary artery coarctation may pose a risk for pulmonary stenosis and subsequent failure to achieve definitive repair. We sought to assess the impact of pulmonary artery coarctation on pulmonary artery growth. METHODS: A retrospective chart review was performed in 130 patients, including 37 single ventricles with a modified Blalock-Taussig shunt as first palliation. Pulmonary artery coarctation was defined as discrete stenosis of the pulmonary artery, with a diameter of less than 3 mm and with the ductus arteriosus connected. Preoperative echocardiography showed pulmonary artery coarctation in 29 patients (22%). Concomitant pulmonary artery plasty was performed in 14 patients with discrete stenosis having a diameter of less than 2 mm. RESULTS: Pre-modified Blalock-Taussig shunt left pulmonary artery z-scores were lower in patients with pulmonary artery coarctation than in those without (-4.0 [-5.8, -2.1] vs -1.7 [-2.6, -0.8], P < .001), and this remained the same even after modified Blalock-Taussig shunt (-2.5 [-5.1, -0.5] vs -0.5 [-2.4, 0.8], P = .010). Concomitant pulmonary artery plasty did not result in catch-up growth of the left pulmonary artery (post-modified Blalock-Taussig shunt left pulmonary artery z-score in patients with pulmonary artery plasty: -3.0 (-6.5, -2.0) versus those without: -1.8 (-3.3, -0.3), P = .279). Definitive repair/Fontan completion was achieved in 111 patients (85%), and this was not affected by the presence of pulmonary artery coarctation. CONCLUSIONS: Pulmonary artery coarctation affected disproportionate pulmonary artery growth throughout the staged repair, but did not result in failure of definitive repair/Fontan completion. Pulmonary artery plasty during the neonatal period did not contribute to catch-up growth of the left pulmonary artery; therefore, surgical indications and timing should be carefully considered.

    DOI: 10.1016/j.jtcvs.2021.09.070

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Books

MISC

  • 当院における1.5心室修復術後遠隔期成績

    井上善紀, 岸良匡, 堀川優衣, 枝木大治, 小松弘明, 辻龍典, 小林純子, 川畑拓也, 黒子洋介, 小谷恭弘, 笠原真悟

    日本小児循環器学会総会・学術集会(Web)   59th   2023

  • 特発性左外腸骨静脈破裂に対する治療経験例からの外科的術式の考察

    森岡 慧, 鈴木 浩之, 枝木 大治, 小松 弘明, 辻 龍典, 横田 豊, 迫田 直也, 村岡 玄也, 小林 純子, 川畑 拓也, 黒子 洋介, 小谷 恭弘, 加藤 源太郎, 廣田 真規, 笠原 真悟

    日本血管外科学会雑誌   32 ( Suppl. )   P17 - 2   2023

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    Language:Japanese   Publisher:(NPO)日本血管外科学会  

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  • 未来の専門医を育てる!岡山大学心臓血管外科の教育論-過去からの伝承と新たな展開-

    小林純子, 笠原真悟

    胸部外科   75 ( 8 )   630 - 633   2022.8

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    Authorship:Lead author   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

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  • DCD動物モデルにおける体外両心機能評価の検討

    小谷恭弘, 小林泰幸, 門脇幸子, 枝木大治, 迫田直也, 小林純子, 川畑拓也, 黒子洋介, 廣田真規, 笠原真悟

    日本心臓移植研究会学術集会プログラム・抄録集(Web)   41st   2022

  • 全国の医局情報をPick Up 19関連施設で年間5000件の心臓手術!75施設での外科研修プログラム

    小林純子

    2022

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Presentations

  • 小児大動脈弁閉鎖不全症に対するRoss手術

    門脇幸子, 枝木大治, 小松弘明, 鈴木浩之, 井上善紀, 岸 良匡, 森岡 慧, 清水春菜, 倉田裕次, 徳田雄平, 吉田文哉, 古谷凌一, 山田隆明, 小林純子, 加藤源太郎, 柚木継二, 藤井泰宏, 黒子洋介, 小谷恭弘, 笠原真悟

    第185回岡山外科会・第8回日本臨床外科学会岡山県支部会  2024.12.21 

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    Event date: 2024.12.21

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 大動脈緊急症

    柚木継二, 井上善紀, 加藤源太郎, 古谷凌一, 山田隆明, 吉田文哉, 清水春菜, 倉田裕次, 徳田雄平, 森岡 慧, 岸 良匡, 鈴木浩之, 枝木大治, 小松弘明, 門脇幸子, 小林純子, 藤井泰宏, 黒子洋介, 小谷恭弘, 笠原真悟

    第185回岡山外科会・第8回日本臨床外科学会岡山県支部会  2024.12.21 

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    Event date: 2024.12.21

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 脳血流維持のためのECMO下TAVI頚動脈アプローチの経験

    井上善紀, 加藤源太郎, 柚木継二, 門田悠暉, 木下 萌, 倉田裕次, 徳田雄平, 森岡 慧, 岸 良匡, 清水春菜, 鈴木浩之, 枝木大治, 小松弘明, 門脇幸子, 小林純子, 藤井泰宏, 黒子洋介, 小谷恭弘, 笠原真悟, 戸田洋伸, 三木崇史

    第125回日本循環器学会中国地方会  2024.12.1 

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    Event date: 2024.11.30 - 2024.12.1

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 無脾症候群合併の単心室症例における肺動脈形成と Additional pulmonary blood flow を併用した中心肺動脈の成長促進

    小林純子, 徳田雄平, 倉田裕次, 森岡 慧, 清水春菜, 岸 良匡, 鈴木浩之, 井上善紀, 枝木大治, 小松弘明, 藤井泰宏, 加藤源太郎, 柚木継二, 黒子洋介, 小谷恭弘, 笠原真悟

    第77回日本胸部外科学会定期学術集会  2024.11.3 

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    Event date: 2024.11.1 - 2024.11.4

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  • 心室中隔欠損を伴う肺動脈閉鎖症に対する自己組織を用いた右室流出路再建

    木村綾梨, 小谷恭弘, 小林泰幸, 徳田雄平, 小林純子, 黒子洋介, 笠原真悟

    第77回日本胸部外科学会定期学術集会  2024.11.3 

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    Event date: 2024.11.1 - 2024.11.4

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Awards

  • 優秀演題賞

    2023.12   第85回 日本臨床外科学会総会  

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  • Furuse Award

    2022.3   Asian Society for Cardiovascular and Thoracic Surgery   Long-term outcome of Fontan completion and the factors associated with interstage mortality in the patients with right isomerism

    Junko Kobayashi

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    Award type:Award from international society, conference, symposium, etc. 

  • the John A. Hawkins Top Scoring Abstract Award

    2020.10   Congenital Heart Surgeons Society and European Congenital Heart Surgeons Association Joint meeting  

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  • Finalist for the 22nd Annual C. Walton Lillehei Resident Competition

    2019.5   American association for thoracic surgery  

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  • Winner of the Dragon’s Den pitch of Clinical stream

    2018.4   Heart & Stroke / Richard Lewar Centre of Excellence, University of Toronto  

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Research Projects

  • 22q11.2欠失症候群との網羅的な比較検討によるファロー四徴症での遺伝子異常の解明

    Grant number:23K08237  2023.04 - 2026.03

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    鈴木 浩之, 小林 純子

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    Grant amount:\4680000 ( Direct expense: \3600000 、 Indirect expense:\1080000 )

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  • ファロー四徴症における右室流出路狭窄の病態発生機序の解明と予後予測マーカーの開発

    Grant number:21K16497  2021.04 - 2024.03

    日本学術振興会  科学研究費助成事業 若手研究  若手研究

    小林 純子

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    Grant amount:\4680000 ( Direct expense: \3600000 、 Indirect expense:\1080000 )

    ファロー四徴症は最も発生頻度の高いチアノーゼ性先天性心疾患である。本疾患の予後は右室流出路狭窄および逆流から生じる右心不全に左右され、個々の症例で経過は大きく異なる。しかし本疾患は未だ原因不明であり治療法は確立されておらず、本邦の指定難病とされている。特に、遠隔期の問題である右心不全とその治療法については、多くが未知の状態である。
    本研究では、ファロー四徴症の病態の中心となる右室流出路狭窄について、その病態発生メカニズムの解明および予後を予測するマーカーの開発を行う。これまで、我々は先天性心疾患患者から手術中に心臓組織検体を採取し、その組織検体の解析および心臓前駆細胞(Cardiac progenitor cells: CPCs)を精製・分離・培養し解析する技術を確立してきた。これまでに培った技術を用いて、本研究では当院で心臓手術を施行するファロー四徴症および類縁疾患患者から手術中に心臓組織検体を採取し、組織検体の遺伝子変異および遺伝子発現解析を行い、またCPCsを精製・分離・培養を行い解析する。
    本研究は患者検体を使用する研究であり、岡山大学病院倫理委員会に研究計画書を提出し、承認を得てから研究を開始する。そして、当院で当該手術を行う患者に対し研究について承認された様式に従って十分な説明をし、同意を得てから手術中に心臓組織検体の採取を行う。患者の個人情報は匿名化して管理し、その取り扱いには十分に配慮を行う。
    令和3年度の研究実績は、研究費取得確認後に研究計画書を岡山大学病院倫理委員会に提出し、承認された(申請番号:研2111-030)。研究計画承認後、術中の心臓検体採取および細胞培養開始のための最終準備を行い、岡山大学病院倫理委員会の所定の様式に従い研究同意を得たうえで、患者心臓組織検体の採取および細胞培養を開始した。

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Class subject in charge

  • Practicals: Cardiovascular Surgery (2024academic year) special  - その他

  • Research Projects: Cardiovascular Surgery (2024academic year) special  - その他

  • Cardiovascular Surgery (Core Clinical Practice) (2024academic year) special  - その他

  • Research Projects and Practicals: Cardiovascular Surgery I (2024academic year) special  - その他

  • Lecture and Research Projects: Cardiovascular Surgery I (2024academic year) special  - その他

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Media Coverage

  • M's story 難手術の先に子どもたちの笑顔 岡山大学病院心臓血管外科助教 小林純子(42) Newspaper, magazine

    山陽新聞  2023.6

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  • 医局紹介 岡山大学学術研究院 医歯薬学域 心臓血管外科 Newspaper, magazine

    ドクターズマガジン  2022.6

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  • 単心室症関与遺伝子を特定 Newspaper, magazine

    山陽新聞  2012.10

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