Faculty Profiles - Otsuka Motoyuki

Papers - Otsuka Motoyuki

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Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine Reviewed

Takahiro Kishikawa, Motoyuki Otsuka, Poh Seng Tan, Motoko Ohno, Xiaochen Sun, Takeshi Yoshikawa, Chikako Shibata, Akemi Takata, Kentaro Kojima, Kenji Takehana, Maki Ohishi, Sana Ota, Tomoyuki Noyama, Yuji Kondo, Masaya Sato, Tomoyoshi Soga, Yujin Hoshida, Kazuhiko Koike

Oncotarget 6 ( 10 ) 8339 - 8352 2015

Diagnostic and therapeutic application of noncoding RNAs for hepatocellular carcinoma Reviewed

Chikako Shibata, Motoyuki Otsuka, Takahiro Kishikawa, Motoko Ohno, Takeshi Yoshikawa, Akemi Takata, Kazuhiko Koike

World Journal of Hepatology 7 ( 1 ) 1 - 6 2015

Loss of histone demethylase KDM6B enhances aggressiveness of pancreatic cancer through downregulation of C/EBP alpha Reviewed

Keisuke Yamamoto, Keisuke Tateishi, Yotaro Kudo, Tomohiko Sato, Shinzo Yamamoto, Koji Miyabayashi, Keisuke Matsusaka, Yoshinari Asaoka, Hideaki Ijichi, Yoshihiro Hirata, Motoyuki Otsuka, Yousuke Nakai, Hiroyuki Isayama, Tsuneo Ikenoue, Mineo Kurokawa, Masashi Fukayama, Norihiro Kokudo, Masao Omata, Kazuhiko Koike

CARCINOGENESIS 35 ( 11 ) 2404 - 2414 2014.11

Impact of PNPLA3 polymorphisms on the development of hepatocellular carcinoma in patients with chronic hepatitis C virus infection Reviewed

Masaya Sato, Naoya Kato, Ryosuke Tateishi, Ryosuke Muroyama, Norie Kowatari, Wenwen Li, Kaku Goto, Motoyuki Otsuka, Shuichiro Shiina, Haruhiko Yoshida, Masao Omata, Kazuhiko Koike

HEPATOLOGY RESEARCH 44 ( 10 ) E137 - E144 2014.10

The flavonoid apigenin inhibits hepatitis C virus replication by decreasing mature microRNA122 levels Reviewed

Chikako Shibata, Motoko Ohno, Motoyuki Otsuka, Takahiro Kishikawa, Kaku Goto, Ryosuke Muroyama, Naoya Kato, Takeshi Yoshikawa, Akemi Takata, Kazuhiko Koike

VIROLOGY 462 42 - 48 2014.8

Specific delivery of microRNA93 into HBV-replicating hepatocytes downregulates protein expression of liver cancer susceptible gene MICA Reviewed

Motoko Ohno, Motoyuki Otsuka, Takahiro Kishikawa, Chikako Shibata, Takeshi Yoshikawa, Akemi Takata, Ryosuke Muroyama, Norie Kowatari, Masaya Sato, Naoya Kato, Shun'ichi Kuroda, Kazuhiko Koike

ONCOTARGET 5 ( 14 ) 5581 - 5590 2014.7

IL28B minor allele is associated with a younger age of onset of hepatocellular carcinoma in patients with chronic hepatitis C virus infection Reviewed

Masaya Sato, Naoya Kato, Ryosuke Tateishi, Ryosuke Muroyama, Norie Kowatari, Wenwen Li, Kaku Goto, Motoyuki Otsuka, Shuichiro Shiina, Haruhiko Yoshida, Masao Omata, Kazuhiko Koike

JOURNAL OF GASTROENTEROLOGY 49 ( 4 ) 748 - 754 2014.4

The role of microRNAs in hepatocarcinogenesis: current knowledge and future prospects Reviewed

Motoyuki Otsuka, Takahiro Kishikawa, Takeshi Yoshikawa, Motoko Ohno, Akemi Takata, Chikako Shibata, Kazuhiko Koike

JOURNAL OF GASTROENTEROLOGY 49 ( 2 ) 173 - 184 2014.2

Histone demethylase KDM4C regulates sphere formation by mediating the cross talk between Wnt and Notch pathways in colonic cancer cells Reviewed

Shinzo Yamamoto, Keisuke Tateishi, Yotaro Kudo, Keisuke Yamamoto, Takayuki Isagawa, Genta Nagae, Takuma Nakatsuka, Yoshinari Asaoka, Hideaki Ijichi, Yoshihiro Hirata, Motoyuki Otsuka, Tsuneo Ikenoue, Hiroyuki Aburatani, Masao Omata, Kazuhiko Koike

CARCINOGENESIS 34 ( 10 ) 2380 - 2388 2013.10

Activation of p38α in T cells regulates the intestinal host defense against attaching and effacing bacterial infections Reviewed

Eun-Jin Shim, Bo-Ram Bang, Seung-Goo Kang, Jianhui Ma, Motoyuki Otsuka, Jiman Kang, Martin Stahl, Jiahuai Han, Changchun Xiao, Bruce A. Vallance, Young Jun Kang

Journal of Immunology 191 ( 5 ) 2764 - 2770 2013.9

Unique Haploinsufficient Role of the MicroRNA-Processing Molecule Dicer1 in a Murine Colitis-Associated Tumorigenesis Model Reviewed

Takeshi Yoshikawa, Motoyuki Otsuka, Takahiro Kishikawa, Akemi Takata, Motoko Ohno, Chikako Shibata, Young Jun Kang, Haruhiko Yoshida, Kazuhiko Koike

PLOS ONE 8 ( 9 ) e71969 2013.9

Inhibition of microRNA122 decreases SREBP1 expression by modulating suppressor of cytokine signaling 3 expression Reviewed

Chikako Shibata, Takahiro Kishikawa, Motoyuki Otsuka, Motoko Ohno, Takeshi Yoshikawa, Akemi Takata, Haruhiko Yoshida, Kazuhiko Koike

Biochemical and Biophysical Research Communications 438 ( 1 ) 230 - 235 2013.8

The flavonoid apigenin improves glucose tolerance through inhibition of microRNA maturation in miRNA103 transgenic mice Reviewed

Motoko Ohno, Chikako Shibata, Takahiro Kishikawa, Takeshi Yoshikawa, Akemi Takata, Kentaro Kojima, Masao Akanuma, Young Jun Kang, Haruhiko Yoshida, Motoyuki Otsuka, Kazuhiko Koike

SCIENTIFIC REPORTS 3 2553 2013.8

Transdifferentiation of human fibroblasts into hepatocyte-like cells by defined transcriptional factors Reviewed

Tomomi Kogiso, Hikaru Nagahara, Motoyuki Otsuka, Keiko Shiratori, Steven F. Dowdy

HEPATOLOGY INTERNATIONAL 7 ( 3 ) 937 - 944 2013.7

MicroRNAs and liver function.

Takata A, Otsuka M, Yoshikawa T, Kishikawa T, Ohno M, Koike K

2013.6

A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region Reviewed

Yuji Urabe, Hidenori Ochi, Naoya Kato, Vinod Kumar, Atsushi Takahashi, Ryosuke Muroyama, Naoya Hosono, Motoyuki Otsuka, Ryosuke Tateishi, Paulisally Hau Yi Lo, Chizu Tanikawa, Masao Omata, Kazuhiko Koike, Daiki Miki, Hiromi Abe, Naoyuki Kamatani, Joji Toyota, Hiromitsu Kumada, Michiaki Kubo, Kazuaki Chayama, Yusuke Nakamura, Koichi Matsuda

Journal of Hepatology 58 ( 5 ) 875 - 882 2013.5

MicroRNA-140 acts as a liver tumor suppressor by controlling NF-kappa B activity by directly targeting DNA methyltransferase 1 (Dnmt1) expression Reviewed

Akemi Takata, Motoyuki Otsuka, Takeshi Yoshikawa, Takahiro Kishikawa, Yohko Hikiba, Shuntaro Obi, Tadashi Goto, Young Jun Kang, Shin Maeda, Haruhiko Yoshida, Masao Omata, Hiroshi Asahara, Kazuhiko Koike

HEPATOLOGY 57 ( 1 ) 162 - 170 2013.1

MicroRNA-140 acts as a liver tumor suppressor by controlling NF-κB activity by directly targeting DNA methyltransferase 1 (Dnmt1) expression. International journal

Hepatology (Baltimore, Md.) 57 ( 1 ) 162 - 70 2013.1

Language：English Publishing type：Research paper (scientific journal)

UNLABELLED: MicroRNAs (miRNAs) are small RNAs that regulate the expression of specific target genes. While deregulated miRNA expression levels have been detected in many tumors, whether miRNA functional impairment is also involved in carcinogenesis remains unknown. We investigated whether deregulation of miRNA machinery components and subsequent functional impairment of miRNAs are involved in hepatocarcinogenesis. Among miRNA-containing ribonucleoprotein complex components, reduced expression of DDX20 was frequently observed in human hepatocellular carcinomas, in which enhanced nuclear factor-κB (NF-κB) activity is believed to be closely linked to carcinogenesis. Because DDX20 normally suppresses NF-κB activity by preferentially regulating the function of the NF-κB-suppressing miRNA-140, we hypothesized that impairment of miRNA-140 function may be involved in hepatocarcinogenesis. DNA methyltransferase 1 (Dnmt1) was identified as a direct target of miRNA-140, and increased Dnmt1 expression in DDX20-deficient cells hypermethylated the promoters of metallothionein genes, resulting in decreased metallothionein expression leading to enhanced NF-κB activity. MiRNA-140-knockout mice were prone to hepatocarcinogenesis and had a phenotype similar to that of DDX20 deficiency, suggesting that miRNA-140 plays a central role in DDX20 deficiency-related pathogenesis. CONCLUSION: These results indicate that miRNA-140 acts as a liver tumor suppressor, and that impairment of miRNA-140 function due to a deficiency of DDX20, a miRNA machinery component, could lead to hepatocarcinogenesis.

DOI： 10.1002/hep.26011

PubMed

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Current status of miRNA-targeting therapeutics and preclinical studies against gastroenterological carcinoma. Reviewed

Shibata C, Otsuka M, Kishikawa T, Yoshikawa T, Ohno M, Takata A, Koike K

Molecular and cellular therapies 1 5 2013

Regulation of the expression of the liver cancer susceptibility gene MICA by microRNAs Reviewed

Takahiro Kishikawa, Motoyuki Otsuka, Takeshi Yoshikawa, Motoko Ohno, Akemi Takata, Chikako Shibata, Yuji Kondo, Masao Akanuma, Haruhiko Yoshida, Kazuhiko Koike

Scientific Reports 3 2739 2013

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Papers - Otsuka Motoyuki