2024/02/02 更新

写真a

アサヌマ マサト
淺沼 幹人
ASANUMA Masato
所属
医歯薬学域 教授
職名
教授
外部リンク

学位

  • 博士(医学) ( 1992年3月   岡山大学 )

研究キーワード

  • 神経薬理学

  • 神経内科学

  • 神経化学

研究分野

  • ライフサイエンス / 神経内科学

  • ライフサイエンス / 神経科学一般

  • ライフサイエンス / 病態神経科学

学歴

  • 岡山大学   Graduate School of Medicine  

    1988年4月 - 1992年3月

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    国名: 日本国

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  • 岡山大学   Medical School   Faculty of Medicine

    1982年4月 - 1988年3月

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    国名: 日本国

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経歴

  • 徳島大学薬学部   非常勤講師

    2016年4月 - 現在

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  • 岡山大学大学院医歯薬学総合研究科   脳神経機構学分野   教授

    2014年7月 - 現在

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  • 国立研究開発法人国立精神・神経医療研究センター   精神保健研究所薬物依存研究部   非常勤研究員

    2007年4月 - 2023年3月

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  • 岡山大学大学院医歯薬学総合研究科   神経情報学分野   准教授

    2001年4月 - 2014年6月

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  • 岡山大学医学部   分子細胞医学研究施設神経情報学部門   助教授

    2000年10月 - 2001年3月

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  • 米国国立保健研究所(NIH)薬物濫用研究所(NIDA)   Molecular Neuropsychiatry Section, Cellular Neuroscience Branch   客員研究員

    1996年9月 - 1998年8月

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    国名:アメリカ合衆国

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  • 岡山大学医学部   分子細胞医学研究施設神経情報学部門   助手

    1995年5月 - 2000年9月

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  • 岡山大学医学部   分子細胞医学研究施設神経情報学部門   非常勤講師

    1995年4月

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  • (財)長寿科学振興財団   リサーチレジデント

    1994年4月 - 1995年3月

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  • 岡山大学医学部   分子細胞医学研究施設神経情報学部門   併任所員

    1992年4月 - 1994年3月

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所属学協会

  • 日本毒性学会

    2017年2月 - 現在

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  • 日本毒性学会生体金属部会(メタルバイオサイエンス研究会)

    2015年2月 - 現在

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  • 日本解剖学会

    2012年8月 - 現在

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  • 日本パーキンソン病・運動障害疾患学会(MDSJ)

    2009年8月 - 現在

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  • 日本薬理学会

    2008年1月 - 現在

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  • 国際神経化学会

    2004年7月 - 現在

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  • 日本神経精神薬理学会

    1999年4月 - 現在

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  • アメリカ神経科学会

    1997年2月 - 現在

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  • 日本神経科学学会

    1995年5月 - 現在

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  • 日本神経学会

    1989年11月 - 現在

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  • 日本神経化学会

    1989年10月 - 現在

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  • 日本薬学会

    2017年10月 - 現在

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  • 日本栄養改善学会

    2010年5月 - 2012年

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  • 神経行動薬理若手研究者の集い

    2010年3月 - 現在

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  • 国際脳研究機関(国際神経科学会)

    1995年5月 - 現在

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  • 国際脳循環代謝学会

    1993年5月 - 2014年

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  • 日本てんかん学会

    1992年11月 - 2007年

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  • 日本脳科学会

    1990年7月 - 2021年3月

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  • 日本老年医学会

    1990年 - 1995年

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  • 日本脳循環代謝学会

    1990年 - 1995年

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  • 日本内科学会

    1989年2月 - 現在

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  • 岡山脳研究セミナー

    1989年 - 現在

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委員歴

  • 日本神経精神薬理学会   企画研究将来構想委員会 委員  

    2022年11月 - 現在   

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    団体区分:学協会

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  • 日本神経学会   代議員  

    2021年5月 - 現在   

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    団体区分:学協会

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  • 日本パーキンソン病・運動障害疾患学会   評議員  

    2020年7月 - 現在   

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  • 日本薬理学会   代議員  

    2018年10月 - 現在   

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  • 日本毒性学会   評議員  

    2017年7月 - 現在   

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  • 日本神経精神薬理学会   企画委員会委員  

    2017年4月 - 2022年11月   

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  • 日本神経精神薬理学会   先端研究推進基盤構築タスクフォース委員  

    2017年4月 - 2022年11月   

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  • 日本毒性学会生体金属部会(メタルバイオサイエンス研究会)   常任幹事  

    2015年2月 - 現在   

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    団体区分:学協会

    メタルバイオサイエンス研究会

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  • 日本解剖学会   代議員  

    2014年8月 - 現在   

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    団体区分:学協会

    日本解剖学会

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  • 日本薬理学会   学術評議員  

    2013年4月 - 現在   

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  • 日本脳科学会   評議員  

    2006年6月 - 2021年3月   

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    団体区分:学協会

    日本脳科学会

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  • 日本神経精神薬理学会   評議員  

    2005年1月 - 現在   

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    団体区分:学協会

    日本神経精神薬理学会

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  • 岡山脳研究セミナー   事務局長  

    2000年 - 現在   

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    団体区分:学協会

    岡山脳研究セミナー

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  • 日本神経化学会   評議員  

    1999年9月 - 現在   

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    団体区分:学協会

    日本神経化学会

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論文

  • Neurogenesis impairment with glial activation in the hippocampus-connected regions of intracerebroventricular streptozotocin-injected mice 査読

    Kaori Masai, Yuta Nakayama, Kotaro Shin, Chiaki Sugahara, Ikuko Miyazaki, Takao Yasuhara, Isao Date, Masato Asanuma

    Neuroscience Letters   820   137598 - 137598   2023年12月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.neulet.2023.137598

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  • Phosphorylated SARM1 is involved in the pathological process of rotenone-induced neurodegeneration 査読

    Hitoshi Murata, May Tha Zin Phoo, Toshiki Ochi, Nahoko Tomonobu, Ken-ichi Yamamoto, Rie Kinoshita, Ikuko Miyazaki, Masahiro Nishibori, Masato Asanuma, Masakiyo Sakaguchi

    The Journal of Biochemistry   174 ( 6 )   533 - 548   2023年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Oxford University Press (OUP)  

    Abstract

    Sterile alpha and Toll/interleukin receptor motif-containing protein 1 (SARM1) is a NAD+ hydrolase that plays a key role in axonal degeneration and neuronal cell death. We reported that c-Jun N-terminal kinase (JNK) activates SARM1 through phosphorylation at Ser-548. The importance of SARM1 phosphorylation in the pathological process of Parkinson’s disease (PD) has not been determined. We thus conducted the present study by using rotenone (an inducer of PD-like pathology) and neurons derived from induced pluripotent stem cells (iPSCs) from healthy donors and a patient with familial PD PARK2 (FPD2). The results showed that compared to the healthy neurons, FPD2 neurons were more vulnerable to rotenone-induced stress and had higher levels of SARM1 phosphorylation. Similar cellular events were obtained when we used PARK2-knockdown neurons derived from healthy donor iPSCs. These events in both types of PD-model neurons were suppressed in neurons treated with JNK inhibitors, Ca2+-signal inhibitors, or by a SARM1-knockdown procedure. The degenerative events were enhanced in neurons overexpressing wild-type SARM1 and conversely suppressed in neurons overexpressing the SARM1-S548A mutant. We also detected elevated SARM1 phosphorylation in the midbrain of PD-model mice. The results indicate that phosphorylated SARM1 plays an important role in the pathological process of rotenone-induced neurodegeneration.

    DOI: 10.1093/jb/mvad068

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    その他リンク: https://academic.oup.com/jb/article-pdf/174/6/533/54447957/mvad068.pdf

  • Multifunctional Metallothioneins as a Target for Neuroprotection in Parkinson’s Disease 査読

    Ikuko Miyazaki, Masato Asanuma

    Antioxidants   12 ( 4 )   894 - 894   2023年4月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MDPI AG  

    Parkinson’s disease (PD) is characterized by motor symptoms based on a loss of nigrostriatal dopaminergic neurons and by non-motor symptoms which precede motor symptoms. Neurodegeneration accompanied by an accumulation of α-synuclein is thought to propagate from the enteric nervous system to the central nervous system. The pathogenesis in sporadic PD remains unknown. However, many reports indicate various etiological factors, such as oxidative stress, inflammation, α-synuclein toxicity and mitochondrial impairment, drive neurodegeneration. Exposure to heavy metals contributes to these etiopathogenesis and increases the risk of developing PD. Metallothioneins (MTs) are cysteine-rich metal-binding proteins; MTs chelate metals and inhibit metal-induced oxidative stress, inflammation and mitochondrial dysfunction. In addition, MTs possess antioxidative properties by scavenging free radicals and exert anti-inflammatory effects by suppression of microglial activation. Furthermore, MTs recently received attention as a potential target for attenuating metal-induced α-synuclein aggregation. In this article, we summarize MTs expression in the central and enteric nervous system, and review protective functions of MTs against etiopathogenesis in PD. We also discuss neuroprotective strategies for the prevention of central dopaminergic and enteric neurodegeneration by targeting MTs. This review highlights multifunctional MTs as a target for the development of disease-modifying drugs for PD.

    DOI: 10.3390/antiox12040894

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  • Central and enteric neuroprotective effects by Eucommia ulmoides extracts on neurodegeneration in rotenone-induced parkinsonian mouse. 査読

    Fuminori Imafuku, Ikuko Miyazaki, Jin Sun, Sunao Kamimai, Takashi Shimizu, Toshiaki Toyota, Yusei Okamoto, Nami Isooka, Ryo Kikuoka, Yoshihisa Kitamura, Masato Asanuma

    Acta Medica Okayama   76 ( 4 )   373 - 383   2022年8月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.18926/AMO/63889

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  • Neuroprotective Effects of Anti-high Mobility Group Box-1 Monoclonal Antibody Against Methamphetamine-Induced Dopaminergic Neurotoxicity 査読

    Kaori Masai, Keita Kuroda, Nami Isooka, Ryo Kikuoka, Shinki Murakami, Sunao Kamimai, Dengli Wang, Keyue Liu, Ikuko Miyazaki, Masahiro Nishibori, Masato Asanuma

    Neurotoxicity Research   39 ( 5 )   1511 - 1523   2021年10月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s12640-021-00402-5

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    その他リンク: https://link.springer.com/article/10.1007/s12640-021-00402-5/fulltext.html

  • Glial cells as possible targets of neuroprotection through neurotrophic and antioxidative molecules in the central and enteric nervous systems in Parkinson’s disease. 査読

    Nami Isooka, Ikuko Miyazaki, Masato Asanuma

    Acta Medica Okayama   75 ( 5 )   549 - 556   2021年10月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Influence of 5-HT2A receptor function on anxiety-like behavior induced by a combination treatment with doxorubicin and cyclophosphamide in rats. 査読 国際誌

    Hironori Tabuchi, Yoshihisa Kitamura, Soichiro Ushio, Shiho Kan, Yudai Wada, Yusuke Sumiyoshi, Yasuhisa Izushi, Ikuko Miyazaki, Masato Asanuma, Toshiaki Sendo

    Psychopharmacology   238 ( 12 )   3607 - 3614   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00213-021-05979-5

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  • Glutathione and Related Molecules in Parkinsonism 招待 査読

    Masato Asanuma, Ikuko Miyazaki

    International Journal of Molecular Sciences   22 ( 16 )   8689 - 8689   2021年8月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/ijms22168689

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  • Lactoferrin-like Immunoreactivity in Distinct Neuronal Populations in the Mouse Central Nervous System. 査読

    Shigeyoshi Shimaoka, Hitomi Hamaoka, Junji Inoue, Masato Asanuma, Ikuo Tooyama, Yoichi Kondo

    Acta Medica Okayama   75 ( 2 )   153 - 167   2021年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.18926/AMO/61894

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  • アストロサイトの亜鉛関連分子を標的としたパーキンソン病治療戦略 招待

    宮崎育子, 浅沼幹人

    日本薬理学雑誌   156 ( 2 )   76 - 80   2021年2月

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    担当区分:最終著者   記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • パーキンソン病での神経保護標的としてのアストロサイトの抗酸化分子 招待

    浅沼幹人, 宮崎育子

    日本薬理学雑誌   156 ( 1 )   14 - 20   2021年1月

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    担当区分:筆頭著者, 責任著者   記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • N-Acetylcysteine Attenuates the Anxiety-Like Behavior and Spatial Cognition Impairment Induced by Doxorubicin and Cyclophosphamide Combination Treatment in Rats 査読

    Yoshihisa Kitamura, Soichiro Ushio, Yusuke Sumiyoshi, Yudai Wada, Ikuko Miyazaki, Masato Asanuma, Toshiaki Sendo

    Pharmacology   106 ( 5-6 )   286 - 293   2021年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1159/000512117

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  • Neuron-Astrocyte Interactions in Parkinson’s Disease 招待 査読

    Ikuko Miyazaki, Masato Asanuma

    Cells   9 ( 12 )   2623 - 2623   2020年12月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/cells9122623

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  • Mirtazapine exerts astrocyte-mediated dopaminergic neuroprotection 査読

    Ryo Kikuoka, Ikuko Miyazaki, Natsuki Kubota, Megumi Maeda, Daiki Kagawa, Masaaki Moriyama, Asuka Sato, Shinki Murakami, Yoshihisa Kitamura, Toshiaki Sendo, Masato Asanuma

    Scientific Reports   10 ( 1 )   20698 - 20698   2020年12月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/s41598-020-77652-4

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    その他リンク: http://www.nature.com/articles/s41598-020-77652-4

  • The Rotenone Models Reproducing Central and Peripheral Features of Parkinson’s Disease 査読

    Ikuko Miyazaki, Masato Asanuma

    NeuroSci   1 ( 1 )   1 - 14   2020年8月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/neurosci1010001

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  • The neurotoxicity of psychoactive phenethylamines “2C series” in cultured monoaminergic neuronal cell lines 査読

    Masato Asanuma, Ikuko Miyazaki, Masahiko Funada

    Forensic Toxicology   38 ( 2 )   394 - 408   2020年7月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s11419-020-00527-w

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    その他リンク: http://link.springer.com/article/10.1007/s11419-020-00527-w/fulltext.html

  • Cerebellar Blood Flow and Gene Expression in Crossed Cerebellar Diaschisis after Transient Middle Cerebral Artery Occlusion in Rats 査読

    Naoya Kidani, Tomohito Hishikawa, Masafumi Hiramatsu, Shingo Nishihiro, Kyohei Kin, Yu Takahashi, Satoshi Murai, Kenji Sugiu, Takao Yasuhara, Ikuko Miyazaki, Masato Asanuma, Isao Date

    International Journal of Molecular Sciences   21 ( 11 )   4137 - 4137   2020年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/ijms21114137

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  • Chronic Systemic Exposure to Low-Dose Rotenone Induced Central and Peripheral Neuropathology and Motor Deficits in Mice: Reproducible Animal Model of Parkinson’s Disease 査読

    Ikuko Miyazaki, Nami Isooka, Fuminori Imafuku, Jin Sun, Ryo Kikuoka, Chieko Furukawa, Masato Asanuma

    International Journal of Molecular Sciences   21 ( 9 )   3254 - 3254   2020年5月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/ijms21093254

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  • Effects of maternal bisphenol A diglycidyl ether exposure during gestation and lactation on behavior and brain development of the offspring 査読

    Ikuko Miyazaki, Ryo Kikuoka, Nami Isooka, Mika Takeshima, Kanau Sonobe, Rei Arai, Hidemaru Funakoshi, Kyle E. Quin, Jonathan Smart, Kazumasa Zensho, Masato Asanuma

    Food and Chemical Toxicology   138   111235 - 111235   2020年4月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.fct.2020.111235

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  • Dopaminergic neuroprotective effects of rotigotine via 5-HT1A receptors: Possibly involvement of metallothionein expression in astrocytes 査読

    Nami Isooka, Ikuko Miyazaki, Ryo Kikuoka, Kouichi Wada, Erika Nakayama, Kotaro Shin, Daichi Yamamoto, Yoshihisa Kitamura, Masato Asanuma

    Neurochemistry International   132   104608 - 104608   2020年1月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.neuint.2019.104608

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  • Attenuation of Macrophage Migration Inhibitory Factor-Stimulated Signaling via S-Nitrosylation 査読

    Kengo Nakahara, Kana Fujikawa, Hideki Hiraoka, Ikuko Miyazaki, Masato Asanuma, Akihiro Ito, Nobumasa Takasugi, Takashi Uehara

    Biological and Pharmaceutical Bulletin   42 ( 6 )   1044 - 1047   2019年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1248/bpb.b19-00025

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  • Effects of Enteric Environmental Modification by Coffee Components on Neurodegeneration in Rotenone-Treated Mice 査読

    Ikuko Miyazaki, Nami Isooka, Kouichi Wada, Ryo Kikuoka, Yoshihisa Kitamura, Masato Asanuma

    Cells   8 ( 3 )   221 - 221   2019年3月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/cells8030221

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  • Region-Specific Neuroprotective Features of Astrocytes against Oxidative Stress Induced by 6-Hydroxydopamine 査読

    Masato Asanuma, Nao Okumura-Torigoe, Ikuko Miyazaki, Shinki Murakami, Yoshihisa Kitamura, Toshiaki Sendo

    International Journal of Molecular Sciences   20 ( 3 )   598 - 598   2019年1月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/ijms20030598

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  • Involvement of 5-HT2A receptor hyperfunction in the anxiety-like behavior induced by doxorubicin and cyclophosphamide combination treatment in rats 査読

    Yuka Nakamura, Yoshihisa Kitamura, Yusuke Sumiyoshi, Nanami Naito, Shiho Kan, Soichiro Ushio, Ikuko Miyazaki, Masato Asanuma, Toshiaki Sendo

    Journal of Pharmacological Sciences   138 ( 3 )   192 - 197   2018年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jphs.2018.10.001

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  • Application of Single Prolonged Stress Induces Post-traumatic Stress Disorder-like Characteristics in Mice. 査読

    Ken-Ichi Tanaka, Takao Yagi, Takeshi Nanba, Masato Asanuma

    Acta Medica Okayama   72 ( 5 )   479 - 485   2018年10月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.18926/AMO/56245

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  • Neuroprotective effect of fermented papaya preparation by activation of Nrf2 pathway in astrocytes 査読

    Shinki Murakami, Ikuko Miyazaki, Masato Asanuma

    Nutritional Neuroscience   21 ( 3 )   176 - 184   2018年3月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/1028415x.2016.1253171

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  • Influence of nicotine on doxorubicin and cyclophosphamide combination treatment-induced spatial cognitive impairment and anxiety-like behavior in rats 査読

    Yoshihisa Kitamura, Erika Kanemoto, Misaki Sugimoto, Ayumi Machida, Yuka Nakamura, Nanami Naito, Hirotaka Kanzaki, Ikuko Miyazaki, Masato Asanuma, Toshiaki Sendo

    Naunyn-Schmiedeberg's Archives of Pharmacology   390 ( 4 )   369 - 378   2017年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00210-016-1338-z

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  • Therapeutic strategy of targeting astrocytes for neuroprotection in parkinson’s disease 査読

    Ikuko Miyazaki, Masato Asanuma

    Current Pharmaceutical Design   23 ( 33 )   4936 - 4947   2017年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2174/1381612823666170710163731

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  • Identification of transcription factors activated by methylmercury in mouse brain 査読

    Min-Soek Kim, Tsutomu Takahashi, Jin-Yong Lee, Nobuhiko Miura, Masato Asanuma, Gi-Wook Hwang, Akira Naganuma

    Fundamental Toxicological Sciences   4 ( 1 )   37 - 39   2017年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Effect of alteration of glutathione content on cell viability in a-synuclein-transfected SH-SY5Y cells. 査読

    Tanaka, K, Sonoda, K, Asanuma, M

    Advances in Parkinson's Disease   6   93 - 100   2017年

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.4236/apd.2017.63010

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  • 3-O-Methyldopa inhibits astrocyte-mediated dopaminergic neuroprotective effects of l-DOPA 査読

    Masato Asanuma, Ikuko Miyazaki

    BMC Neuroscience   17 ( 1 )   52   2016年12月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1186/s12868-016-0289-0

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  • L-Theanine protects against excess dopamine-induced neurotoxicity in the presence of astrocytes 査読

    Mika Takeshima, Ikuko Miyazaki, Shinki Murakami, Taizo Kita, Masato Asanuma

    Journal of Clinical Biochemistry and Nutrition   59 ( 2 )   93 - 99   2016年9月

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    担当区分:最終著者, 責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:The Society for Free Radical Research Japan  

    DOI: 10.3164/jcbn.16-15

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  • In vitro quantitative determination of the concentration of the polymerization agent methyl 2-benzoylbenzoate in intravenous injection solution and the cytotoxic effects of the chemical on normal human peripheral blood mononuclear cells 査読

    Chiaki Tsuboi, Yoichi Kawasaki, Kei Yoshitome, Kenta Yagi, Taro Miura, Satoru Esumi, Ikuko Miyazaki, Masato Asanuma, Yoshihisa Kitamura, Toshiaki Sendo

    Environmental Science and Pollution Research   23 ( 10 )   10262 - 10269   2016年5月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1007/s11356-016-6332-y

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  • Neuroprotective effects of levetiracetam target xCT in astrocytes in parkinsonian mice 査読

    Ikuko Miyazaki, Shinki Murakami, Nao Torigoe, Yoshihisa Kitamura, Masato Asanuma

    Journal of Neurochemistry   136 ( 1 )   194 - 204   2016年1月

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    担当区分:最終著者, 責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1111/jnc.13405

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  • Anti-high mobility group box 1 antibody exerts neuroprotection in a rat model of Parkinson's disease 査読

    Tatsuya Sasaki, Keyue Liu, Takashi Agari, Takao Yasuhara, Jun Morimoto, Mihoko Okazaki, Hayato Takeuchi, Atsuhiko Toyoshima, Susumu Sasada, Aiko Shinko, Akihiko Kondo, Masahiro Kameda, Ikuko Miyazaki, Masato Asanuma, Cesario V. Borlongan, Masahiro Nishibori, Isao Date

    Experimental Neurology   275   220 - 231   2016年1月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.expneurol.2015.11.003

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  • Serotonin 1A Receptors on Astrocytes as a Potential Target for the Treatment of Parkinson's Disease 査読

    Ikuko Miyazaki, Masato Asanuma

    Current Medicinal Chemistry   23 ( 7 )   686 - 700   2016年

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BENTHAM SCIENCE PUBL LTD  

    Astrocytes are the most abundant neuron-supporting glial cells in the central nervous system. The neuroprotective role of astrocytes has been demonstrated in various neurological disorders such as amyotrophic lateral sclerosis, spinal cord injury, stroke and Parkinson's disease (PD). Astrocyte dysfunction or loss-of-astrocytes increases the susceptibility of neurons to cell death, while astrocyte transplantation in animal studies has therapeutic advantage. We reported recently that stimulation of serotonin 1A (5-HT1A) receptors on astrocytes promoted astrocyte proliferation and upregulated antioxidative molecules to act as a neuroprotectant in parkinsonian mice. PD is a progressive neurodegenerative disease with motor symptoms such as tremor, bradykinesia, rigidity and postural instability, that are based on selective loss of nigrostriatal dopaminergic neurons, and with non-motor symptoms such as orthostatic hypotension and constipation based on peripheral neurodegeneration. Although dopaminergic therapy for managing the motor disability associated with PD is being assessed at present, the main challenge remains the development of neuroprotective or disease-modifying treatments. Therefore, it is desirable to find treatments that can reduce the progression of dopaminergic cell death. In this article, we summarize first the neuroprotective properties of astrocytes targeting certain molecules related to PD. Next, we review neuroprotective effects induced by stimulation of 5-HT1A receptors on astrocytes. The review discusses new promising therapeutic strategies based on neuroprotection against oxidative stress and prevention of dopaminergic neurodegeneration.

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  • Changes in Metallothionein Isoform Expression in the Bones of Ovariectomized Rats 査読

    Chiharu Sogawa, Mika Ikegame, Ikuko Miyazaki, Toshiaki Ara, Yasuhiro Imamura, Yuka Okusha, Kazumi Ohyama, Masato Asanuma, Norio Sogawa, Toshio Yamamoto, Ken-ichi Kozaki

    Journal of Hard Tissue Biology   25 ( 1 )   21 - 26   2016年

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Society for Hard Tissue Regenerative Biology  

    DOI: 10.2485/jhtb.25.21

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  • Serotonin-1A agonist 8-OH-DPAT alleviates motor dysfunction and motor neuron degeneration in a model of amyotrophic lateral sclerosis. 査読

    Ikuko Miyazaki, Shinki Murakami, Takashi Nakano, Nao Torigoe, Ryo Kikuoka, Yoshihisa Kitamura, Toshiaki Sendo, Masato Asanuma

    Annals of Pharmacology and Pharmaceutics   1 ( 1 )   1003   2016年

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  • Doxorubicin and cyclophosphamide treatment produces anxiety-like behavior and spatial cognition impairment in rats: Possible involvement of hippocampal neurogenesis via brain-derived neurotrophic factor and cyclin D1 regulation 査読

    Yoshihisa Kitamura, Sayo Hattori, Saori Yoneda, Saori Watanabe, Erika Kanemoto, Misaki Sugimoto, Toshiki Kawai, Ayumi Machida, Hirotaka Kanzaki, Ikuko Miyazaki, Masato Asanuma, Toshiaki Sendo

    Behavioural Brain Research   292   184 - 193   2015年10月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.bbr.2015.06.007

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  • Long-Term Systemic Exposure to Rotenone Induces Central and Peripheral Pathology of Parkinson’s Disease in Mice 査読

    Shinki Murakami, Ikuko Miyazaki, Ko Miyoshi, Masato Asanuma

    Neurochemical Research   40 ( 6 )   1165 - 1178   2015年6月

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    担当区分:最終著者, 責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1007/s11064-015-1577-2

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  • Possible involvement of iron-induced oxidative insults in neurodegeneration. 査読

    Asano Takeshi, Koike Masato, Sakata Shin-ichi, Takeda Yukiko, Nakagawa Tomoko, Hatano Taku, Ohashi Satoshi, Funayama Manabu, Yoshimi Kenji, Asanuma Masato, Toyokuni Shinya, Mochizuki Hideki, Uchiyama Yasuo, Hattori Nobutaka, Iwai Kazuhiro

    Neuroscience letters   588   29 - 35   2015年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier Ireland Ltd.  

    Involvement of iron in the development of neurodegenerative disorders has long been suggested, and iron that cannot be stored properly is suggested to induce iron toxicity. To enhance iron uptake and suppress iron storage in neurons, we generated transgenic (Tg) mice expressing iron regulatory protein 2 (IRP2), a major regulator of iron metabolism, in a neuron-specific manner. Although very subtle, IRP2 was expressed in all regions of brain examined. In the Tg mice, mitochondrial oxidative insults were observed including generation of 4-hydroxynonenal modified proteins, which appeared to be removed by a mitochondrial quality control protein Parkin. Inter-crossing of the Tg mice to Parkin knockout mice perturbed the integrity of neurons in the substantia nigra and provoked motor symptoms. These results suggest that a subtle, but chronic increase in IRP2 induces mitochondrial oxidative insults and accelerates neurodegeneration in a mouse model of Parkinson's disease. Thus, the IRP2 Tg may be a useful tool to probe the roles of iron-induced mitochondrial damages in neurodegeraration research.

    DOI: 10.1016/j.neulet.2014.12.052

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  • ハルミンの薬物依存性ならびに細胞毒性の評価:植物由来幻覚成分の有害作用について.

    舩田正彦, 竹林美佳, 宮崎育子, 浅沼幹人, 青尾直也, 和田 清

    精神保健研究   61 ( 28 )   61 - 72   2015年

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    記述言語:日本語   出版者・発行元:国立精神・神経医療研究センター精神保健研究所  

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  • Visualization of Astrocytic Primary Cilia in the Mouse Brain by Immunofluorescent Analysis Using the Cilia Marker Arl13b 査読

    Kyosuke Kasahara, Ko Miyoshi, Shinki Murakami, Ikuko Miyazaki, Masato Asanuma

    Acta Medica Okayama   68 ( 6 )   317 - 322   2014年12月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    In vertebrates, almost all somatic cells extend a single immotile cilium, referred to as a primary cilium. Increasing evidence suggests that primary cilia serve as cellular antennae in many types of tissues by sensing chemical or mechanical stimuli in the milieu surrounding the cells. In rodents an antibody to adenylyl cyclase 3 (AC3) has been widely used to label the primary cilia of neurons in vivo by immunostaining, whereas the lack of markers for the primary cilia of astrocytes has made it difficult to observe astrocytic primary cilia in vivo. Here, we obtained a visualization of astrocytic primary cilia in the mouse brain. In the somatosensory cortex, a large portion of neurons and astrocytes at postnatal day 10 (P10), and of neurons at P56 had AC3-positive primary cilia, whereas only approx. one-half of the astrocytes in the P56 mice carried primary cilia weakly positive for AC3. In contrast, the majority of astrocytes had ADP-ribosylation factor-like protein 13B (Arl13b)-positive primary cilia in the somatosensory cortex and other brain regions of P56 mice. The lengths of astrocytic primary cilia positive for Arl13b varied among the brain regions. Our data indicate that Arl13b is a noteworthy marker of astrocytic primary cilia in the brain.

    DOI: 10.18926/AMO/53020

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  • Methylphenidate improves learning impairments and hyperthermia-induced seizures caused by an Scn1a mutation. 査読

    Ohmori Iori, Kawakami Nozomi, Liu Sumei, Wang Haijiao, Miyazaki Ikuko, Asanuma Masato, Michiue Hiroyuki, Matsui Hideki, Mashimo Tomoji, Ouchida Mamoru

    Epilepsia   55 ( 10 )   1558 - 1567   2014年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley Periodicals, Inc.  

    Developmental disorders including cognitive deficit, hyperkinetic disorder, and autistic behaviors are frequently comorbid in epileptic patients with SCN1A mutations. However, the mechanisms underlying these developmental disorders are poorly understood and treatments are currently unavailable. Using a rodent model with an Scn1a mutation, we aimed to elucidate the pathophysiologic basis and potential therapeutic treatments for developmental disorders stemming from Scn1a mutations.

    DOI: 10.1111/epi.12750

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  • Neuroprotective Effects of Metallothionein Against Rotenone-Induced Myenteric Neurodegeneration in Parkinsonian Mice 査読

    Murakami Shinki, Miyazaki Ikuko, Sogawa Norio, Miyoshi Ko, Asanuma Masato

    Neurotoxicity Research   26 ( 3 )   285 - 298   2014年10月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer  

    Parkinson's disease (PD) is a neurodegenerative disease with motor symptoms as well as non-motor symptoms that precede the onset of motor symptoms. Mitochondrial complex I inhibitor, rotenone, has been widely used to reproduce PD pathology in the central nervous system (CNS) and enteric nervous system (ENS). We reported previously that metallothioneins (MTs) released from astrocytes can protect dopaminergic neurons against oxidative stress. The present study examined the changes in MT expression by chronic systemic rotenone administration in the striatum and colonic myenteric plexus of C57BL mice. In addition, we investigated the effects of MT depletion on rotenone-induced neurodegeneration in CNS and ENS using MT-1 and MT-2 knockout (MT KO) mice, or using primary cultured neurons from MT KO mice. In normal C57BL mice, subcutaneous administration of rotenone for 6 weeks caused neurodegeneration, increased MT expression with astrocytes activation in the striatum and myenteric plexus. MT KO mice showed more severe myenteric neuronal damage by rotenone administration after 4 weeks than wild-type mice, accompanied by reduced astroglial activation. In primary cultured mesencephalic neurons from MT KO mice, rotenone exposure induced neurotoxicity in dopaminergic neurons, which was complemented by addition of recombinant protein. The present results suggest that MT seems to provide protection against neurodegeneration in ENS of rotenone-induced PD model mice.

    DOI: 10.1007/s12640-014-9480-1

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  • Striatal Astrocytes Act as a Reservoir for L-DOPA 査読

    Masato Asanuma, Ikuko Miyazaki, Shinki Murakami, Francisco J. Diaz-Corrales, Norio Ogawa

    PLoS ONE   9 ( 9 )   e106362 - e106362   2014年9月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Public Library of Science (PLoS)  

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  • Effects of (+)-8-OH-DPAT on the duration of immobility during the forced swim test and hippocampal cell proliferation in ACTH-treated rats 査読

    Ayaka Miyake, Yoshihisa Kitamura, Ikuko Miyazaki, Masato Asanuma, Toshiaki Sendo

    Pharmacology Biochemistry and Behavior   122   240 - 245   2014年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    In the present study, we examined the effect of ACTH on the immobilization of rats in the forced swim test and hippocampal cell proliferation after administration of the 5-HT1A receptor agonist, R-(+)-8-hydroxy-2-di-n-propylamino tetralin ((+)-8-OH-DPAT). Chronic treatment with (+)-8-OH-DPAT (0.01-0.1 mg/kg, s.c.) significantly decreased the duration of immobility in saline- and ACTH-treated rats. Chronic administration of ACTH caused a significant decrease in hippocampal cell proliferation. However, (+)-8-OH-DPAT significantly normalized cell proliferation in ACTH-treated rats. We then investigated the effects of (+)-8-OH-DPAT on the expression of brain-derived neurotrophic factor (BDNF) and cyclin D1 (elements of cyclic adenosine monophosphate response element-binding protein (CREB)-BDNF and Wnt signaling pathways, respectively) in the hippocampus of saline- and ACTH-treated rats. ACTH treatment significantly decreased the expression of cyclin D1, while treatment with (+)-8-OH-DPAT normalized the expression of cyclin D1 in ACTH-treated rats. However, the expression of BDNF did not change in either saline- or ACTH-treated rats. These findings suggest that the antidepressant effects of (+)-8-OH-DPAT in treatment-resistant animals may be attributed to an enhancement of hippocampal cell proliferation, at least in part due to an enhancement of cyclin D1 expression. (C) 2014 Elsevier Inc All rights reserved.

    DOI: 10.1016/j.pbb.2014.04.003

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  • Lack of Dopaminergic Inputs Elongates the Primary Cilia of Striatal Neurons 査読 国際誌

    Ko Miyoshi, Kyosuke Kasahara, Shinki Murakami, Mika Takeshima, Natsuko Kumamoto, Asako Sato, Ikuko Miyazaki, Shinsuke Matsuzaki, Toshikuni Sasaoka, Taiichi Katayama, Masato Asanuma

    PLoS ONE   9 ( 5 )   e97918 - e97918   2014年5月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Public Library of Science (PLoS)  

    In the rodent brain, certain G protein-coupled receptors and adenylyl cyclase type 3 are known to localize to the neuronal primary cilium, a primitive sensory organelle protruding singly from almost all neurons. A recent chemical screening study demonstrated that many compounds targeting dopamine receptors regulate the assembly of Chlamydomonas reinhardtii flagella, structures which are analogous to vertebrate cilia. Here we investigated the effects of dopaminergic inputs loss on the architecture of neuronal primary cilia in the rodent striatum, a brain region that receives major dopaminergic projections from the midbrain. We first analyzed the lengths of neuronal cilia in the dorsolateral striatum of hemi-parkinsonian rats with unilateral lesions of the nigrostriatal dopamine pathway. In these rats, the striatal neuronal cilia were significantly longer on the lesioned side than on the non-lesioned side. In mice, the repeated injection of reserpine, a dopamine-depleting agent, elongated neuronal cilia in the striatum. The combined administration of agonists for dopamine receptor type 2 (D2) with reserpine attenuated the elongation of striatal neuronal cilia. Repeated treatment with an antagonist of D2, but not of dopamine receptor type 1 (D1), elongated the striatal neuronal cilia. In addition, D2-null mice displayed longer neuronal cilia in the striatum compared to wild-type controls. Reserpine treatment elongated the striatal neuronal cilia in D1-null mice but not in D2-null mice. Repeated treatment with a D2 agonist suppressed the elongation of striatal neuronal cilia on the lesioned side of hemi-parkinsonian rats. These results suggest that the elongation of striatal neuronal cilia following the lack of dopaminergic inputs is attributable to the absence of dopaminergic transmission via D2 receptors. Our results provide the first evidence that the length of neuronal cilia can be modified by the lack of a neurotransmitter's input.

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  • Protective Effects of Phytochemical Antioxidants Against Neurotoxin-Induced Degeneration of Dopaminergic Neurons 査読

    Taizo Kita, Masato Asanuma, Ikuko Miyazaki, Mika Takeshima

    Journal of Pharmacological Sciences   124 ( 3 )   313 - 319   2014年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPANESE PHARMACOLOGICAL SOC  

    The specific toxicity to dopaminergic neurons of psychostimulants and neurotoxins has been extensively studied in vivo and in vitro, and findings have been used to establish animal models of amphetamine psychosis or Parkinson's disease. The multiple mechanisms of neurotoxicity operating in these disorders are known to involve oxidative stress or neuroinflammation, producing the characteristic behavioral and neuropathlogical changes arising from injured dopaminergic neurons and glial cells. A number of studies have shown that glia-targeting antioxidants play important roles in protecting against the neurotoxicity caused by psychostimulants or neurotoxins. Phytochemicals, which are non-nutritive plant chemicals, protect dopaminergic neurons and glial cells from damage caused by psychostimulants or neurotoxins. The objective of this review was to evaluate the involvement of glial cells in dopaminergic neuron specific toxicity and to explore the neuroprotective activity of phytochemicals in terms of anti-inflammatory and antioxidant action.

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  • Effects of Bupropion and Pramipexole on Cell Proliferation in the Hippocampus of Adrenocorticotropic Hormone-Treated Rats 査読

    Yuka Onoue, Keiko Kuwatsuka, Ikuko Miyazaki, Masato Asanuma, Yoshihisa Kitamura, Toshiaki Sendo

    Biological & Pharmaceutical Bulletin   37 ( 2 )   327 - 330   2014年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PHARMACEUTICAL SOC JAPAN  

    The dopamine reuptake inhibitor bupropion and dopamine D2/3 receptor agonist pramipexole have been clinically proven to improve both depression and treatment-resistant depression. We examined its influence on the duration of immobility during the forced swim test in adrenocorticotropic hormone (ACTH)-treated rats and further analyzed the possible role of the dopamine nerve system in this effect. Bupropion and pramipexole significantly decreased the duration of immobility in normal and ACTH-treated rats. We previously demonstrated that the chronic administration of ACTH caused a significant decrease in hippocampal cell proliferation and neurogenesis. In this study, we used the mitotic marker 5-bromo-2'-deoxyridine to investigate the effects of bupropion and pramipexole on cell proliferation in the subgranular zone of the hippocampal dentate gyms following chronic treatment with ACTH. The ACTH treatment for 14 d decreased adult hippocampal cell proliferation. The chronic administration of bupropion for 14 d blocked the loss of cell proliferation resulting from the chronic treatment with ACTH, whereas pramipexole did not. The administration of bupropion may have treatment-resistant antidepressive properties, which may be partly attributed to the normalization of hippocampal cell proliferation.

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  • Metallothionein deficiency exacerbates diabetic nephropathy in streptozotocin-induced diabetic mice 査読

    Hiromi Tachibana, Daisuke Ogawa, Norio Sogawa, Masato Asanuma, Ikuko Miyazaki, Naoto Terami, Takashi Hatanaka, Chikage Sato Horiguchi, Atsuko Nakatsuka, Jun Eguchi, Jun Wada, Hiroshi Yamada, Kohji Takei, Hirofumi Makino

    American Journal of Physiology-Renal Physiology   306 ( 1 )   F105 - F115   2014年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:American Physiological Society  

    Oxidative stress and inflammation play important roles in diabetic complications, including diabetic nephropathy. Metallothionein (MT) is induced in proximal tubular epithelial cells as an antioxidant in the diabetic kidney; however, the role of MT in renal function remains unclear. We therefore investigated whether MT deficiency accelerates diabetic nephropathy through oxidative stress and inflammation. Diabetes was induced by streptozotocin injection in MT-deficient (MT−/−) and MT+/+ mice. Urinary albumin excretion, histological changes, markers for reactive oxygen species (ROS), and kidney inflammation were measured. Murine proximal tubular epithelial (mProx24) cells were used to further elucidate the role of MT under high-glucose conditions. Parameters of diabetic nephropathy and markers of ROS and inflammation were accelerated in diabetic MT−/− mice compared with diabetic MT+/+ mice, despite equivalent levels of hyperglycemia. MT deficiency accelerated interstitial fibrosis and macrophage infiltration into the interstitium in the diabetic kidney. Electron microscopy revealed abnormal mitochondrial morphology in proximal tubular epithelial cells in diabetic MT−/− mice. In vitro studies demonstrated that knockdown of MT by small interfering RNA enhanced mitochondrial ROS generation and inflammation-related gene expression in mProx24 cells cultured under high-glucose conditions. The results of this study suggest that MT may play a key role in protecting the kidney against high glucose-induced ROS and subsequent inflammation in diabetic nephropathy.

    DOI: 10.1152/ajprenal.00034.2013

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  • アストロサイトによる神経機能修飾とパーキンソン病での神経保護 招待

    浅沼幹人

    岡山医学会雑誌   126 ( 3 )   203 - 208   2014年

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(大学,研究機関等紀要)  

    DOI: 10.4044/joma.126.203

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  • お茶の旨味成分テアニンのアストログリア細胞における細胞保護効果

    喜多大三, 浅沼幹人, 宮崎育子, 竹島美香

    九州栄養福祉大学研究紀要   10 ( 10 )   179 - 191   2013年12月

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    記述言語:日本語   掲載種別:研究論文(大学,研究機関等紀要)   出版者・発行元:九州栄養福祉大学  

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  • Targeting 5-HT1A receptors in astrocytes to protect dopaminergic neurons in parkinsonian models 査読

    Ikuko Miyazaki, Masato Asanuma, Shinki Murakami, Mika Takeshima, Nao Torigoe, Yoshihisa Kitamura, Ko Miyoshi

    Neurobiology of Disease   59   244 - 256   2013年11月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Astrocytes are abundant neuron-supporting glial cells that harbor a powerful arsenal of neuroprotective antioxidative molecules and neurotrophic factors. Here we examined whether enrichment with healthy striatal astrocytes can provide neuroprotection against progressive dopaminergic neurodegeneration. Serotonin 1A (5-HT1A) agonist 8-OH-DPAT induced astrocyte proliferation and increased metallothionein-1/-2 (MT-1/-2), antioxidative molecules, in cultured astrocytes and the striatum of mice. Primary cultured mesencephalic dopamine neurons were protected against oxidative stress by preincubation with conditioned media from 8-OH-DPAT-treated astrocytes. These protective effects were canceled by 5-HT1A antagonist or MT-1/-2-specific antibody. Furthermore, reduction of nigrostriatal dopaminergic neurons in 6-hydroxydopamine-lesioned parkinsonian model mice was significantly abrogated by repeated injections of 8-OH-DPAT. Treatment with 8-OH-DPAT markedly increased the expression of MT in striatal astrocytes in the hemi-parkinsonian mice. Our study provides a promising therapeutic strategy of neuroprotection against oxidative stress and progressive dopaminergic neurodegeneration by demonstrating the efficacy of targeting 5-HT1A receptors in astrocytes. © 2013 Elsevier Inc.

    DOI: 10.1016/j.nbd.2013.08.003

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  • Transplantation of melanocytes obtained from the skin ameliorates apomorphine-induced abnormal behavior in rodent hemi-parkinsonian models 査読

    Asanuma Masato, Miyazaki Ikuko, Francisco J. Diaz-Corrales, Higashi Youichirou, Namba Masayoshi, Ogawa Norio

    PLOS ONE   8 ( 6 )   e65983 - e65983   2013年6月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PUBLIC LIBRARY SCIENCE  

    Tyrosinase, which catalyzes both the hydroxylation of tyrosine and consequent oxidation of L-DOPA to form melanin in melanocytes, is also expressed in the brain, and oxidizes L-DOPA and dopamine. Replacement of dopamine synthesis by tyrosinase was reported in tyrosine hydroxylase null mice. To examine the potential benefits of autograft cell transplantation for patients with Parkinson's disease, tyrosinase-producing cells including melanocytes, were transplanted into the striatum of hemi-parkinsonian model rats or mice lesioned with 6-hydroxydopamine. Marked improvement in apomorphine-induced rotation was noted at day 40 after intrastriatal melanoma cell transplantation. Transplantation of tyrosinase cDNA-transfected hepatoma cells, which constitutively produce L-DOPA, resulted in marked amelioration of the asymmetric apomorphine-induced rotation in hemi-parkinsonian mice and the effect was present up to 2 months. Moreover, parkinsonian mice transplanted with melanocytes from the back skin of black newborn mice, but not from albino mice, showed marked improvement in the apomorphine-induced rotation behavior up to 3 months after the transplantation. Dopamine-positive signals were seen around the surviving transplants in these experiments. Taken together with previous studies showing dopamine synthesis and metabolism by tyrosinase, these results highlight therapeutic potential of intrastriatal autograft cell transplantation of melanocytes in patients with Parkinson's disease.

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  • Protective effect of cepharanthin on cisplatin-induced renal toxicity through metallothionein expression 査読

    Norio Sogawa, Kanji Hirai, Chiharu Sogawa, Kazumi Ohyama, Ikuko Miyazaki, Goichi Tsukamoto, Masato Asanuma, Akira Sasaki, Shigeo Kitayama

    Life Sciences   92 ( 12 )   727 - 732   2013年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Aims Cisplatin (CDDP) is a potent anticancer agent, but severe renal toxicity can limit its use. We investigated the protective effect of cepharanthin (CE), a biscoclaurin alkaloid, on the renal toxicity of CDDP. Main methods Mice were given CDDP along with CE. Effects of CE on CDDP toxicity were investigated by assaying markers of renal toxicity together with MT expression, and by histopathological examination of the kidney. MT-null mice were also examined. Key findings CE induced expression of metallothionein (MT). Pre-administration of CE attenuated an increase in blood urea nitrogen (BUN) concentrations after the CDDP injection. A histochemical analysis demonstrated protection against CDDP-induced necrocytosis of kidney tissues by CE. The protective effect of CE did not occur in the MT-null mice. Significance Pretreatment with CE may reduce the renal toxicity of CDDP through expression of MT. © 2013 Elsevier Inc.

    DOI: 10.1016/j.lfs.2013.01.031

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  • アストロサイトとParkinson病治療 招待

    浅沼幹人, 宮崎育子

    神経内科   79 ( 2 )   257 - 261   2013年

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • The mechanisms of electroconvulsive stimuli in BrdU-positive cells of the dentate gyrus in ACTH-treated rats 査読

    Keiko Kuwatsuka, Hiromi Hayashi, Yuka Onoue, Ikuko Miyazaki, Toshihiro Koyama, Masato Asanuma, Yoshihisa Kitamura, Toshiaki Sendo

    Journal of Pharmacological Sciences   122 ( 1 )   34 - 41   2013年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    In clinical studies, electroconvulsive stimuli have been associated with improvements in both depression and treatment-resistant depression. In a previous study, treatment with adrenocorticotropic hormone (ACTH) for 14 days decreased adult hippocampal cell proliferation. Furthermore, electroconvulsive stimuli significantly decreased the duration of immobility following repeated administration of ACTH for 14 days in rats. The present study was undertaken to further characterize the mechanism of treatment-resistant antidepressant effects of electroconvulsive stimuli by measuring cell proliferation, brain-derived neurotrophic factor (BDNF) levels, and phosphorylated and total cyclic adenosine monophosphate (cAMP) response element-binding protein (pCREB/CREB) levels in the hippocampus of ACTH-treated rats. Electroconvulsive stimuli increased cell proliferation in both saline-treated and ACTH-treated rats. Mature-BDNF protein levels showed a tendency to decrease in ACTH-treated rats. Electroconvulsive stimuli treatment increased mature-BDNF protein levels in the hippocampus of both saline-treated and ACTH-treated rats. Furthermore, electroconvulsive stimuli increased phospho-Ser133-CREB (pCREB) levels and the ratio of pCREB/CREB in both saline-treated and ACTH-treated rats. These findings suggest that the treatment-resistant antidepressant effects of electroconvulsive stimuli may be attributed, at least in part, to an enhancement of hippocampal cell proliferation. © The Japanese Pharmacological Society.

    DOI: 10.1254/jphs.13015FP

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  • テアニンの中枢作用に関する文献的考察.

    喜多大三, 浅沼幹人, 宮崎育子, 竹島美香

    九州栄養福祉大学研究紀要   9 ( 9 )   45 - 58   2012年12月

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    記述言語:日本語   掲載種別:研究論文(大学,研究機関等紀要)   出版者・発行元:九州栄養福祉大学  

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  • Centrosomal aggregates and Golgi fragmentation disrupt vesicular trafficking of DAT 査読

    Francisco J. Diaz-Corrales, Ikuko Miyazaki, Masato Asanuma, Diego Ruano, Rosa M. Rios

    Neurobiology og Aging   33 ( 10 )   2462 - 2477   2012年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    Lewy bodies containing the centrosomal protein gamma-tubulin and fragmentation of Golgi apparatus (GA) have been described in nigral neurons of Parkinson's disease (PD) patients. However, the relevance of these features in PD pathophysiology remains unknown. We analyzed the impact of proteasome inhibition in the formation of gamma-tubulin-containing aggregates as well as on GA structure. SH-SY5Y cells were treated with the proteasome inhibitor Z-Leu-Leu-Leu-al (MG132) to induce centrosomal-protein aggregates. Then, microtubules (MTs) and Golgi dynamics, as well as the vesicular transport of dopamine transporter (DAT) were evaluated both in vitro and in living cells. MG132 treatment induced gamma-tubulin aggregates which altered microtubule nucleation. MG132-treated cells containing gamma-tubulin aggregates showed fragmentation of GA and perturbation of the trans-Golgi network. Under these conditions, the DAT accumulated at the centrosomal-Golgi region indicating that the vesicular transport of DAT was disrupted. Thus, centrosomal aggregates and fragmentation of GA are 2 closely related processes that could result in the disruption of the vesicular transport of DAT toward the plasma membrane in a model of dopaminergic neuronal degeneration. (C) 2012 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.neurobiolaging.2011.11.014

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  • Cyclooxygenase-Independent Neuroprotective Effects of Aspirin Against Dopamine Quinone-Induced Neurotoxicity 査読

    Masato Asanuma, Ikuko Miyazaki, Yuri Kikkawa, Naotaka Kimoto, Mika Takeshima, Shinki Murakami, Ko Miyoshi

    Neurochemical Research   37 ( 9 )   1944 - 1951   2012年9月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER/PLENUM PUBLISHERS  

    Prostaglandin H synthase exerts not only cyclooxygenase activity but also peroxidase activity. The latter activity of the enzyme is thought to couple with oxidation of dopamine to dopamine quinone. Therefore, it has been proposed that cyclooxygenase inhibitors could suppress dopamine quinone formation. In the present study, we examined effects of various cyclooxygenase inhibitors against excess methyl L-3,4-dihydroxyphenylalanine (L-DOPA)-induced quinoprotein (protein-bound quinone) formation and neurotoxicity using dopaminergic CATH.a cells. The treatment with aspirin inhibited excess methyl L-DOPA-induced quinoprotein formation and cell death. However, acetaminophen did not show protective effects, and indomethacin and meloxicam rather aggravated these methyl L-DOPA-induced changes. Aspirin and indomethacin did not affect the level of glutathione that exerts quenching dopamine quinone in dopaminergic cells. In contrast with inhibiting effects of higher dose in the previous reports, relatively lower dose of aspirin that affected methyl L-DOPA-induced quinoprotein formation and cell death failed to prevent cyclooxygenase-induced dopamine chrome generation in cell-free system. Furthermore, aspirin but not acetaminophen or meloxicam showed direct dopamine quinone-scavenging effects in dopamine-semiquinone generating systems. The present results suggest that cyclooxygenase shows little contribution to dopamine oxidation in dopaminergic cells and that protective effects of aspirin against methyl L-DOPA-induced dopamine quinone neurotoxicity are based on its cyclooxygenase-independent property.

    DOI: 10.1007/s11064-012-0813-2

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  • Effluent free radicals are associated with residual renal function and predict technique failure in peritoneal dialysis patients. 査読

    Hiroshi Morinaga, Hitoshi Sugiyama, Tatsuyuki Inoue, Keiichi Takiue, Yoko Kikumoto, Masashi Kitagawa, Shigeru Akagi, Kazushi Nakao, Yohei Maeshima, Ikuko Miyazaki, Masato Asanuma, Makoto Hiramatsu, Hirofumi Makino

    Peritoneal Dialysis International   32 ( 4 )   453 - 461   2012年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MULTIMED INC  

    Objective: Residual renal function (RRF) is associated with low oxidative stress in peritoneal dialysis (PD). In the present study, we investigated the relationship between the impact of oxidative stress on RRF and patient outcomes during PD.
    Methods: Levels of free radicals (FRs) in effluent from the overnight dwell in 45 outpatients were determined by electron spin resonance spectrometry. The FR levels, clinical parameters, and the level of 8-hydroxy-2'-deoxyguanosine were evaluated at study start. The effects of effluent FR level on technique and patient survival were analyzed in a prospective cohort followed for 24 months.
    Results: Levels of effluent FRs showed significant negative correlations with daily urine volume and residual renal Kt/V, and positive correlations with plasma beta(2)-microglobulin and effluent 8-hydroxy-2'-deoxyguanosine. A highly significant difference in technique survival (p < 0.05), but not patient survival, was observed for patients grouped by effluent FR quartile. The effluent FR level was independently associated with technique failure after adjusting for patient age, history of cardiovascular disease, and presence of diabetes mellitus (p < 0.001). The level of effluent FRs was associated with death-censored technique failure in both univariate (p < 0.001) and multivariate (p < 0.01) hazard models. Compared with patients remaining on PD, those withdrawn from the modality had significantly higher levels of effluent FRs (p < 0.005).
    Conclusions: Elevated effluent FRs are associated with RRF and technique failure in stable PD patients. These findings highlight the importance of oxidative stress as an unfavorable prognostic factor in PD and emphasize that steps should be taken to minimize oxidative stress in these patients. Perit Dial Int 2012; 32(4): 453-461

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  • Dipeptidyl compounds ameliorate the serum-deprivation-induced reduction in cell viability via the neurotrophin-activating effect in SH-SY5Y cells 査読

    Ken-ichi Tanaka, Hiroya Ogo, Hiroaki Kaji, Kaori Miyatake, Erika Tokudome, Kanako Sonoda, Norio Ogawa, Masato Asanuma

    Neurological Research   34 ( 6 )   619 - 622   2012年7月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MANEY PUBLISHING  

    Objectives and methods: We have searched for low-molecular-weight compounds as potent new non-immunosuppressive immunophilin ligands (NI-IPLs) that are stronger than existent NI-IPLs such as GPI1046 and/or V10367 from the perspective of neuroprotective efficacy. We selected six dipeptidyl compounds as new NI-IPL candidates, and first examined the effects of each of these compounds on the serum-deprivation-induced reduction in the viability of SH-SY5Y cells. In addition, we clarified the effects of these compounds on neurotrophin release into medium in SH-SY5Y cells.
    Results: Pre-treatment with Leu-Ile and Ile-Ile prevented the serum deprivation-induced reduction in cell viability in SH-SY5Y cells. In naive SH-SY5Y cells, treatment with Leu-Ile and Ile-Ile for 24 hours significantly increased both brain-derived neurotrophic factor and glial cell-line-derived neurotrophic factor releases in comparison with relative vehicle treatments. Moreover, none of the dipeptidyl compounds could prevent the concanavalin A-induced enhancement in interleukin-2 and interleukin-4 release in mouse spleen cells.
    Discussion: The immunosuppressive effect is not essential to the neuroprotective properties of dipeptidyl compounds, and Leu-Ile and Ile-Ile have neurotrophin-activating effects, like FK506 and its existing non-immunosuppressive derivatives.

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  • ACTH反復投与ラットにおける海馬細胞新生の減少及びそのメカニズムに関する検討. 招待

    林 宏美, 土居真穂, 尾上由華, 鍬塚圭子, 三宅彩香, 小山敏広, 四宮一昭, 宮崎育子, 浅沼幹人, 北村佳久

    薬学雑誌   132 ( 2 )   173 - 178   2012年

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    記述言語:日本語   掲載種別:研究論文(研究会,シンポジウム資料等)   出版者・発行元:公益社団法人 日本薬学会  

    We previously reported that adrenocorticotropic hormone (ACTH)-treated rats serve as a valuable animal model for tricyclic antidepressant-resistant depressive conditions. The present study was undertaken to investigate the changes in neurogenesis in the hippocampus of ACTH-treated rats. Chronic treatment of ACTH decreased the number of bromodeoxyuridine-labeled cells in the dentate gyrus, and the coadministration of imipramine and lithium, and electroconvulsive stimuli recovered these reductions. Furthermore, chronic ACTH treatment also decreased the expression of brain-derived neurotrophic factor, and the coadministration of imipramine and lithium, and electroconvulsive stimuli recovered these reductions. These results suggest that antidepressant-resistant depression is caused by the suppression of neurogenesis, and the coadministration of imipramine and lithium, and electroconvulsive stimuli exert an antidepressant-like effect by recovering proliferative signals and neurogenesis.<br>

    DOI: 10.1248/yakushi.132.173

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  • L-テアニンのグリア細胞に対する保護作用に関する研究─アストロサイトにおけるL-テアニンによる抗酸化保護作用の賦活─.

    喜多大三, 浅沼幹人, 宮崎育子, 竹島美香

    九州栄養福祉大学研究紀要   8 ( 8 )   43 - 53   2011年12月

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    記述言語:日本語   掲載種別:研究論文(大学,研究機関等紀要)   出版者・発行元:九州栄養福祉大学  

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  • Protective effects of baicalein against excess L-DOPA-induced dopamine quinone neurotoxicity 査読

    Mika Takeshima, Maiko Murata, Natsuho Urasoe, Shinki Murakami, Ikuko Miyazaki, Masato Asanuma, Taizo Kita

    Neurological Research   33 ( 10 )   1050 - 1056   2011年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MANEY PUBLISHING  

    Objectives: Baicalein, a flavonoid derived from the root of Scutelaria baicalensis Georgi, possesses antioxidative properties including reactive oxygen species scavenging and lipid peroxidation inhibiting activities. The present study was undertaken to investigate the neuroprotective effect of baicalein against dopamine (DA) neurotoxicity induced by exposure to a synthetic DA precursor, L-3,4-dihydroxyphenylalanine (L-DOPA), in cultured dopaminergic CATH. a cells.
    Methods and results: Exposure to L-DOPA for 24 hours reduced the number of viable cells and enhanced protein-bound quinone (quinoprotein) formation in the cell. Both effects were prevented by simultaneous treatment with baicalein. In addition, baicalein prevented the formation of DA semiquinone radicals from DA in an in vitro cell-free system. Long-term baicalein treatment for 96 hours also protected against excess L-DOPA-induced cell death, and also increased glutathione (GSH) levels in CATH. a cells.
    Discussion: Our results indicate that baicalein has neuroprotective properties against excess L-DOPA-induced DA neurotoxicity through the suppression of DA quinone formation. Furthermore, the long-term treatment of baicalein upregulates intracellular GSH contents, which may also exert neuroprotective effects against oxidative stress-induced neuronal damage.

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  • Factors That Influence Primary Cilium Length 査読

    Ko Miyoshi, Kyosuke Kasahara, Ikuko Miyazaki, Masato Asanuma

    Acta Medica Okayama   65 ( 5 )   279 - 285   2011年10月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    Almost all mammalian cells carry one primary cilium that functions as a biosensor for chemical and mechanical stimuli. Genetic damages that compromise cilia formation or function cause a spectrum of disorders referred to as ciliapathies. Recent studies have demonstrated that some pharmacological agents and extracellular environmental changes can alter primary cilium length. Renal injury is a well-known example of an environmental insult that triggers cilia length modification. Lithium treatment causes primary cilia to extend in several cell types including neuronal cells; this phenomenon is likely independent of glycogen synthase kinase-3 beta inhibition. In renal epithelial cell lines, deflection of the primary cilia by fluid shear shortens them by reducing the intracellular cyclic AMP level, leading to a subsequent decrease in mechanosensitivity to fluid shear. Primary cilium length is also influenced by the dynamics of actin filaments and microtubules through the levels of soluble tubulin in the cytosol available for primary cilia extension. Thus, mammalian cells can adapt to the extracellular environment by modulating the primary cilium length, and this feedback system utilizing primary cilia might exist throughout the mammalian body. Further investigation is required concerning the precise molecular mechanisms underlying the control of primary cilium length in response to environmental factors.

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  • alpha 7 Nicotinic acetylcholine receptors in the central amygdaloid nucleus alter naloxone-induced withdrawal following a single exposure to morphine 査読

    Shigeru Ishida, Yoichi Kawasaki, Hiroaki Araki, Masato Asanuma, Hisashi Matsunaga, Toshiaki Sendo, Hiromu Kawasaki, Yutaka Gomita, Yoshihisa Kitamura

    Psychopharmacology   214 ( 4 )   923 - 931   2011年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    Negative motivational withdrawal from acute opiate dependence was induced by an opioid antagonist, and the withdrawal signs prevented by pretreatment with nicotine.
    The present study was undertaken to examine the mechanism of nicotine-induced attenuation of withdrawal precipitated by naloxone in rats administered a single dose of morphine.
    Conditioned place aversion (CPA) was precipitated by naloxone in rats exposed once to morphine. Nicotinic acetylcholine receptor (nAChR) agonists were microinjected into the central amygdaloid nucleus (CeA) before naloxone was administered. Additionally, c-Fos expression in the amygdala was measured in rats exposed to alpha 7 nAChR ligands.
    The microinjection of nicotine (0.3 and 1.0 mu g/mu l) into the CeA dose-dependently inhibited naloxone-induced CPA. This inhibition of CPA was reversed by methyllycaconitine (MLA), an alpha 7 nAChR antagonist. CPA was also significantly attenuated by the microinjection of tropisetron (3.0 mu g/mu l), an alpha 7 nAChR agonist and 5-hydroxytriptamine 3 (5-HT3) receptor antagonist, but not by ondansetron (1.0 and 3.0 mu g/mu l), a 5-HT3 receptor antagonist. The microinjection of PNU-282987 (3.0 mu g/mu l), a selective alpha 7 nAChR agonist, into the CeA also inhibited CPA. Furthermore, nicotine increased c-Fos expression in the CeA, but not the medial or basolateral amygdaloid nucleus. The increase of c-Fos in the CeA was significantly inhibited by MLA.
    Nicotine-induced attenuation of CPA precipitated by naloxone is mediated by the alpha 7 nAChR subtype, and the CeA is one of the regions of the brain involved in the effect of nicotine on acutely opiate-dependent subjects.

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  • Astrocyte-Derived Metallothionein Protects Dopaminergic Neurons from Dopamine Quinone Toxicity 査読

    Ikuko Miyazaki, Masato Asanuma, Yuri Kikkawa, Mika Takeshima, Shinki Murakami, Ko Miyoshi, Norio Sogawa, Taizo Kita

    Glia   59 ( 3 )   435 - 451   2011年3月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-LISS  

    Our previous studies demonstrated the involvement of quinone formation in dopaminergic neuron dysfunction in the L-DOPA-treated parkinsonian model and in methamphetamine (METH) neurotoxicity. We further reported that the cysteine-rich metal-binding metallothionein (MT) family of proteins protects dopaminergic neurons against dopamine (DA) quinone neurotoxicity by its quinone-quenching property. The aim of this study was to examine MT induction in astrocytes in response to excess DA and the potential neuroprotective effects of astrocyte-derived MTs against DA quinone toxicity. DA exposure significantly upregulated MT-1/-2 in cultured striatal astrocytes, but not in mesencephalic neurons. This DA-induced MT upregulation in astrocytes was blocked by treatment with a DA-transporter (DAT) inhibitor, but not by DA-receptor antagonists. Expression of nuclear factor erythroid 2-related factor (Nrf2) and its binding activity to antioxidant response element of MT-1 gene were significantly increased in the astrocytes after DA exposure. Nuclear translocation of Nrf2 was suppressed by the DAT inhibitor. Quinone formation and reduction of mesencephalic DA neurons after DA exposure were ameliorated by preincubation with conditioned media from DA-treated astrocytes. These protective effects were abrogated by MT-1/-2-specific antibody. Adding exogenous MT-1 to glial conditioned media also showed similar neuroprotective effects. Furthermore, MT-1/-2 expression was markedly elevated specifically in reactive astrocytes in the striatum of L-DOPA-treated hemi-parkinsonian mice or METH-injected mice. These results suggested that excess DA taken up by astrocytes via DAT upregulates MT-1/-2 expression specifically in astrocytes, and that MTs or related molecules secreted specifically by astrocytes protect dopaminergic neurons from damage through quinone quenching and/or scavenging of free radicals. (C)2010 Wiley-Liss, Inc.

    DOI: 10.1002/glia.21112

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  • Chronic Treatment with Imipramine and Lithium Increases Cell Proliferation in the Hippocampus in Adrenocorticotropic Hormone-Treated Rats 査読

    Yoshihisa Kitamura, Maho Doi, Keiko Kuwatsuka, Yuka Onoue, Ikuko Miyazaki, Kazuaki Shinomiya, Toshihiro Koyama, Toshiaki Sendo, Hiromu Kawasaki, Masato Asanuma, Yutaka Gomita

    Biological & Pharmaceutical Bulletin   34 ( 1 )   77 - 81   2011年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PHARMACEUTICAL SOC JAPAN  

    Adult hippocampal neurogenesis is reported to change in animal models of depression and antidepressants. We have used the mitotic marker 5-bromo-2'-deoxyyridine to address the effects of imipramine and lithium on cell proliferation and survival following chronic treatment with adrenocorticotropic hormone (ACTH) in the subgranular zone of the hippocampal dentate gyrus. ACTH treatment for 14d decreased adult hippocampal cell proliferation and survival. Coadministration of imipramine and lithium for 14d blocked the loss of cell proliferation but not cell survival resulting from the chronic treatment with ACTH. The coadministration of imipramine and lithium may have treatment-resistant antidepressive properties, which may be attributed, in part, to a normalization of hippocampal cell proliferation.

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  • パーキンソン病とアストロサイト─新たな神経保護療法の標的. 招待

    浅沼幹人, 宮崎育子

    Clinical Neuroscience   29 ( 11 )   1295 - 1297   2011年

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • High glucose increases metallothionein expression in renal proximal tubular epithelial cells. 査読

    Daisuke Ogawa, Masato Asanuma, Ikuko Miyazaki, Hiromi Tachibana, Jun Wada, Norio Sogawa, Takeshi Sugaya, Shinji Kitamura, Yohei Maeshima, Kenichi Shikata, Hirofumi Makino

    Experimental Diabetes Research   2011   534872 - 534872   2011年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:HINDAWI PUBLISHING CORPORATION  

    Metallothionein(MT) is an intracellular metal-binding, cysteine-rich protein, and is a potent antioxidant that protects cells and tissues from oxidative stress. Although the major isoforms MT-1 and -2 (MT-1/-2) are highly inducible in many tissues, the distribution and role of MT-1/-2 in diabetic nephropathy are poorly understood. In this study, diabetes was induced in adult male rats by streptozotocin, and renal tissues were stained with antibodies for MT-1/-2. MT-1/-2 expression was also evaluated in mProx24 cells, a mouse renal proximal tubular epithelial cell line, stimulated with high glucose medium and pretreated with the antioxidant vitamin E. MT-1/-2 expression was gradually and dramatically increased, mainly in the proximal tubular epithelial cells and to a lesser extent in the podocytes in diabetic rats, but was hardly observed in control rats. MT-1/-2 expression was also increased by high glucose stimulation in mProx24 cells. Because the induction of MT was suppressed by pretreatment with vitamin E, the expression of MT-1/-2 is induced, at least in part, by high glucose-induced oxidative stress. These observations suggest that MT-1/-2 is induced in renal proximal tubular epithelial cells as an antioxidant to protect the kidney from oxidative stress, and may offer a novel therapeutic target against diabetic nephropathy.

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  • Effects of Imipramine and Lithium on the Suppression of Cell Proliferation in the Dentate Gyrus of the Hippocampus in Adrenocorticotropic Hormone-treated Rats 査読

    Maho Doi, Ikuko Miyazaki, Tomoko Nagamachi, Kazuaki Shinomiya, Hisashi Matsunaga, Toshiaki Sendo, Hiromu Kawasaki, Masato Asanuma, Yutaka Gomita, Yoshihisa Kitamura

    Acta Medica Okayama   64 ( 4 )   219 - 223   2010年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells. The administration of imipramine or lithium alone for 14 days had no effect in saline-treated rats. The effect of ACTH was blocked by the administration of imipramine. Furthermore, the coadministration of imipramine and lithium for 14 days significantly increased the number of Ki-67-positive cells in both the saline and ACTH-treated rats. The coadministration of imipramine and lithium normalized the cell proliferation in the dentate gyrus of the hippocampus in rats treated with ACTH.

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  • Effects of bupropion on the forced swim test and release of dopamine in the nucleus accumbens in ACTH-treated rats 査読

    Yoshihisa Kitamura, Takahiko Yagi, Kouhei Kitagawa, Kazuaki Shinomiya, Hiromu Kawasaki, Masato Asanuma, Yutaka Gomita

    Naunyn-Schmiedebergs Archives of Pharmacology   382 ( 2 )   151 - 158   2010年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    The dopamine reuptake inhibitor bupropion has clinically been proven to improve depression and treatment-resistant depression. We examined its influence on the duration of immobility during the forced swim test in adrenocorticotropic hormone (ACTH)-treated rats and further analyzed the possible role of dopamine receptors in this effect. Additionally, the mechanism by which bupropion acts in this model was explored specifically in relation to the site of action through the use of microinjections into the medial prefrontal cortex and nucleus accumbens. Bupropion significantly decreased the duration of immobility in normal and ACTH-treated rats. This effect was blocked by D2 and D3 receptor antagonists in normal rats. Furthermore, infusions of bupropion into the nucleus accumbens, but not medial prefrontal cortex, decreased the immobility of normal and ACTH-treated rats during the forced swim test. Bupropion treatment plus repeated ACTH treatment significantly increased the extracellular dopamine concentration. These findings suggest the antidepressant-like effect of bupropion to be related to levels of dopamine in the rat nucleus accumbens.

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  • Induction of Parkinsonism-Related Proteins in the Spinal Motor Neurons of Transgenic Mouse Carrying a Mutant SOD1 Gene 査読

    Nobutoshi Morimoto, Makiko Nagai, Kazunori Miyazaki, Yasuyuki Ohta, Tomoko Kurata, Yasushi Takehisa, Yoshio Ikeda, Tohru Matsuura, Masato Asanuma, Koji Abe

    Journal of Neuroscience Research   88 ( 8 )   1804 - 1811   2010年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-LISS  

    Amyotrophic lateral sclerosis is a progressive and fatal disease caused by selective death of motor neurons, and a number of these patients carry mutations in the superoxide dismutase 1 (SOD1) gene involved in ameliorating oxidative stress. Recent studies indicate that oxidative stress and disruption of mitochondrial homeostasis is a common mechanism for motor neuron degeneration in amyotrophic lateral sclerosis and the loss of midbrain dopamine neurons in Parkinson&apos;s disease. Therefore, the present study investigated the presence and alterations of familial Parkinson&apos;s disease-related proteins, PINK1 and DJ-1, in spinal motor neurons of G93ASOD1 transgenic mouse model of amyotrophic lateral sclerosis. Following onset of disease, PINK1 and DJ-1 protein expression increased in the spinal motor neurons. The activated form of p53 also increased and translocated to the nuclei of spinal motor neurons, followed by increased expression of p53-activated gene 608 (PAG608). This is the first report demonstrating that increased expression of PAG608 correlates with activation of phosphorylated p53 in spinal motor neurons of an amyotrophic lateral sclerosis model. These results provide further evidence of the profound correlations between spinal motor neurons of amyotrophic lateral sclerosis and parkinsonism-related proteins. (C) 2010 Wiley-Liss, Inc.

    DOI: 10.1002/jnr.22341

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  • Neuroprotective Effects of Zonisamide Target Astrocyte 査読

    Masato Asanuma, Ikuko Miyazaki, Francisco J. Diaz-Corrales, Naotaka Kimoto, Yuri Kikkawa, Mika Takeshima, Ko Miyoshi, Miho Murata

    Annals of Neurology   67 ( 2 )   239 - 249   2010年2月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-LISS  

    Objective: Recent double-blind, controlled trials in Japan showed that the antiepileptic agent zonisamide (ZNS)improves the cardinal symptoms of Parkinson&apos;s disease. Glutathione (GSH) exerts antioxidative activity through quenching reactive oxygen species and dopamine quinone. GSH depletion within dopaminergic neurons impairs mitochondrial complex I activity, followed by age-dependent nigrostriatal neurodegeneration. This study examined changes in GSH and GSH synthesis-related molecules, and the neuroprotective effects of ZNS on dopaminergic neurodegeneration using 6-hydroxydopamine-injected hemiparkinsonian mice brain and cultured neurons or astrocytes.
    Methods and Results: ZNS increased both the cell number and GSH levels in astroglial C6 cells, but not in dopaminergic neuronal CATH.a cells. Repeated injections of ZNS (30mg/kg intraperitoneally) for 14 days also significantly increased GSH levels and S100 beta-positive astrocytes in mouse basal ganglia. Repeated ZNS injections (30mg/kg) for 7 days in the hemiparkinsonian mice increased the expression of cystine/glutamate exchange transporter xCT in activated astrocytes, which supply cysteine to neurons for GSH synthesis. Treatment of these mice with ZNS also increased GSH levels and completely suppressed striatal levodopa-induced quinone formation. Reduction of nigrostriatal dopamine neurons in the lesioned side of hemiparkinsonian mice was significantly abrogated by repeated injections of ZNS with or without adjunctive levodopa starting 3 weeks after 6-hydroxydopamine lesioning.
    Interpretation: These results provide new pharmacological evidence for the effects of ZNS. ZNS markedly increased GSH levels by enhancing the astroglial cystine transport system and/or astroglial proliferation via S100 beta production or secretion. ZNS acts as a neuroprotectant against oxidative stress and progressive dopaminergic neurodegeneration. ANN NEUROL 2010;67:239-249

    DOI: 10.1002/ana.21885

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  • A study on bioactivity and function of chemical compounds in food and foodstuff: Search for angiotensin I-converting enzyme inhibitory substances in some edible mushrooms using fluorescent substrate.

    Haruhiko Aoyagi, Yumiyo Tsukamoto, Chiho Furuno, Setsuko Ando, Kouki Matsubara, Taizo Kita, Masato Asanuma

    九州栄養福祉大学研究紀要   6 ( 6 )   9 - 20   2009年12月

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    記述言語:英語   掲載種別:研究論文(大学,研究機関等紀要)   出版者・発行元:九州栄養福祉大学  

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  • 食材及び食品に含まれる化学物質の生理活性とその機能─ドパミン神経培養系におけるフィチン酸の作用─

    浦添夏帆, 村田麻衣子, 青柳東彦, 安東勢津子, 宮崎育子, 浅沼幹人, 喜多大三

    九州栄養福祉大学研究紀要   6 ( 6 )   75 - 86   2009年12月

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    記述言語:日本語   掲載種別:研究論文(大学,研究機関等紀要)   出版者・発行元:九州栄養福祉大学  

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  • Lithium treatment elongates primary cilia in the mouse brain and in cultured cells 査読

    Ko Miyoshi, Kyosuke Kasahara, Ikuko Miyazaki, Masato Asanuma

    Biochemical and Biophysical Research Communications   388 ( 4 )   757 - 762   2009年10月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE  

    The molecular mechanisms underlying the therapeutic effects of lithium, a first-line antimanic mood stabilizer, have not yet been fully elucidated. Treatment of the algae Chlamydomonas reinhardtii with lithium has been shown to induce elongation of their flagella, which are analogous structures to vertebrate cilia. In the mouse brain, adenylyl cyclase 3 (AC3) and certain neuropeptide receptors colocalize to the primary cilium of neuronal cells, suggesting a chemosensory function for the primary cilium in the nervous system. Here we show that lithium treatment elongates primary cilia in the mouse brain and in cultured cells. Brain sections from mice chronically fed with Li(2)CO(3) were subjected to immunofluorescence study. Primary cilia carrying both AC3 and the receptor for melanin-concentrating hormone (MCH) were elongated in the dorsal striatum and nucleus accumbens of lithium-fed mice, as compared to those of control animals. Moreover, lithium-treated NIH3T3 cells and cultured striatal neurons exhibited elongation of the primary cilia. The present results provide initial evidence that a psychotropic agent can affect ciliary length in the central nervous system, and furthermore suggest that lithium exerts its therapeutic effects via the upregulation of cilia-mediated MCH sensing. These findings thus contribute novel insights into the pathophysiology of bipolar mood disorder and other psychiatric diseases. (C) 2009 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.bbrc.2009.08.099

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  • Effects of galantamine on L-NAME-induced behavioral impairment in Y-maze task in mice 査読

    Ken-ichi Tanaka, Takao Yagi, Ryosuke Shimakoshi, Koji Azuma, Takeshi Nanba, Hiroya Ogo, Akiko Tamura, Masato Asanuma

    Neuroscience Letters   462 ( 3 )   235 - 238   2009年10月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Nitric oxide (NO) may play a role in the established processes of learning and memory. We examined the effects of N-omega-nitro-L-arginine methylester (L-NAME), a nonselective inhibitor of NO synthase (NOS), on the performance of mice in a Y-maze task. L-NAME (100 mg/kg) markedly impaired spontaneous alternation behavior. However, galantamine (0.5 mg/kg) significantly attenuated this L-NAME-induced impairment. To clarify the molecular basis underlying galantamine's protective effects against L-NAME-induced impairment of spontaneous alternation behavior, we tested the ability of mecamylamine, an antagonist of nicotinic ACh receptor (nAChR), and scopolamine, an antagonist of muscarinic ACh receptor, to reduce galantamine's protective effects, and found that only the former had such an ability. Galantamine significantly also reduced L-NAME-induced decreases in NOx levels. However, mecamylamine cancelled galantamine's efficacy in countering the L-NAME-induced decrease in NOx levels. In the present study, we have determined that galantamine's protection against L-NAME-induced impairment of spontaneous alternation behavior in the Y-maze task might be mediated mainly by NOergic activation via the nAChR-related pathway. (c) 2009 Elsevier Ireland Ltd. All rights reserved.

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  • Pericentrin, a centrosomal protein related to microcephalic primordial dwarfism, is required for olfactory cilia assembly in mice 査読

    Ko Miyoshi, Kyosuke Kasahara, Ikuko Miyazaki, Shoko Shimizu, Manabu Taniguchi, Shinsuke Matsuzaki, Masaya Tohyama, Masato Asanuma

    FASEB Journal   23 ( 10 )   3289 - 3297   2009年10月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:FEDERATION AMER SOC EXP BIOL  

    The Drosophila pericentrin-like protein has been shown to be essential for the formation of the sensory cilia of chemosensory and mechanosensory neurons by mutant analysis in flies, while the in vivo function of pericentrin, a well-studied mammalian centrosomal protein related to microcephalic primordial dwarfism, has been unclear. To determine whether pericentrin is required for ciliogenesis in mammals, we generated and analyzed mice with a hypomorphic mutation of Pcnt encoding the mouse pericentrin. Immunofluorescence analysis demonstrated that olfactory cilia of chemosensory neurons in the nasal olfactory epithelium were malformed in the homozygous mutant mice. On the other hand, the assembly of motile and primary cilia of non-neuronal epithelial cells and the formation of sperm flagella were not affected in the Pcnt-mutant mice. The defective assembly of olfactory cilia in the mutant was apparent from birth. The mutant animals displayed reduced olfactory performance in agreement with the compromised assembly of olfactory cilia. Our findings suggest that pericentrin is essential for the assembly of chemosensory cilia of olfactory receptor neurons, but it is not globally required for cilia formation in mammals.-Miyoshi, K., Kasahara, K., Miyazaki, I., Shimizu, S., Taniguchi, M., Matsuzaki, S., Tohyama, M., Asanuma, M. Pericentrin, a centrosomal protein related to microcephalic primordial dwarfism, is required for olfactory cilia assembly in mice. FASEB J. 23, 3289-3297 ( 2009). www.fasebj.org

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  • Effects of pramipexole on the duration of immobility during the forced swim test in normal and ACTH-treated rats 査読

    Kouhei Kitagawa, Yoshihisa Kitamura, Toshiaki Miyazaki, Junya Miyaoka, Hiromu Kawasaki, Masato Asanuma, Toshiaki Sendo, Yutaka Gomita

    Naunyn-Schmiedebergs Archives of Pharmacology   380 ( 1 )   59 - 66   2009年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    The dopamine D2/D3 receptor agonist pramipexole has clinically been proven to improve depression or treatment-resistant depression. However, the involvement of the dopamine receptor system on the effect of pramipexole on depression remains unclear. We examined the influence of pramipexole on the duration of immobility during the forced swim test in normal and adrenocorticotropic hormone (ACTH)-treated rats and further analyzed the possible role of dopamine receptors in this effect. Additionally, the mechanism by which pramipexole acts in this model was explored specifically in relation to the site of action through the use of microinjections into the intramedial prefrontal cortex and nucleus accumbens. Pramipexole (0.3-1 mg/kg) significantly decreased the duration of immobility in normal and ACTH-treated rats. This effect was blocked by L-741,626, a D2 receptor antagonist, and nafadotride, a D3 receptor antagonist, in normal rats. Furthermore, infusions of pramipexole into the intranucleus accumbens, but not the medial prefrontal cortex, decreased the immobility of normal and ACTH-treated rats during the forced swim test. Taken together, the results of these experiments suggested that pramipexole, administered into the intranucleus accumbens rather than the medial prefrontal cortex, exerted an antidepressant-like effect on ACTH-treated rats via the dopaminergic system. The immobility-decreasing effect of pramipexole may be mediated by dopamine D2 and D3 receptors.

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  • Approaches to Prevent Dopamine Quinone-Induced Neurotoxicity 査読

    Ikuko Miyazaki, Masato Asanuma

    Neurochemical Research   34 ( 4 )   698 - 706   2009年4月

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    担当区分:最終著者   記述言語:英語   出版者・発行元:SPRINGER/PLENUM PUBLISHERS  

    Dopamine (DA) and its metabolites containing two hydroxyl residues exert cytotoxicity in dopaminergic neuronal cells, primarily due to the generation of highly reactive DA and DOPA quinones. Quinone formation is closely linked to other representative hypotheses such as mitochondrial dysfunction, inflammation, oxidative stress, and dysfunction of the ubiquitin-proteasome system, in the pathogenesis of neurodegenerative diseases such as Parkinson&apos;s disease and methamphetamine-induced neurotoxicity. Therefore, pathogenic effects of the DA quinone have focused on dopaminergic neuron-specific oxidative stress. Recently, various studies have demonstrated that some intrinsic molecules and several drugs exert protective effects against DA quinone-induced damage of dopaminergic neurons. In this article, we review recent studies on some neuroprotective approaches against DA quinone-induced dysfunction and/or degeneration of dopaminergic neurons.

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  • Reduction of Nuclear Peroxisome Proliferator-Activated Receptor gamma Expression in Methamphetamine-Induced Neurotoxicity and Neuroprotective Effects of Ibuprofen 査読

    Takeshi Tsuji, Masato Asanuma, Ikuko Miyazaki, Ko Miyoshi, Norio Ogawa

    Neurochemical Research   34 ( 4 )   764 - 774   2009年4月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER/PLENUM PUBLISHERS  

    We examined changes in nuclear peroxisome proliferator-activated receptor gamma (PPAR gamma) in the striatum in methamphetamine (METH)-induced dopaminergic neurotoxicity, and also examined effects of treatment with drugs possessing PPAR gamma agonistic properties. The marked reduction of nuclear PPAR gamma-expressed cells was seen in the striatum 3 days after METH injections (4 mg/kg x 4, i.p. with 2-h interval). The reduction of dopamine transporter (DAT)-positive signals and PPAR gamma expression, and accumulation of activated microglial cells were significantly and dose-dependently attenuated by four injections of a nonsteroidal anti-inflammatory drug and a PPAR gamma ligand, ibuprofen (10 or 20 mg/kg x 4, s.c.) given 30 min prior to each METH injection, but not by either a low or high dose of aspirin. Either treatment of ibuprofen or aspirin, that showed no effects on METH-induced hyperthermia, significantly blocked the METH-induced striatal cyclooxygenase (COX) expression. Furthermore, the treatment of an intrinsic PPAR gamma ligand 15d-PG J2 also attenuated METH injections-induced reduction of striatal DAT. Therefore, the present study suggests the involvement of reduction of PPAR gamma expression in METH-induced neurotoxicity. Taken together with the previous report showing protective effects of other PPAR gamma ligand, these results imply that the protective effects of ibuprofen against METH-induced neurotoxicity may be based, in part, on its anti-inflammatory PPAR gamma agonistic properties, but not on its COX-inhibiting property or hypothermic effect.

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  • Dopamine-Induced Behavioral Changes and Oxidative Stress in Methamphetamine-Induced Neurotoxicity 査読

    Taizo Kita, Ikuko Miyazaki, Masato Asanuma, Mika Takeshima, George C. Wagner

    International Review of Neurobiology   88   43 - 64   2009年

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    掲載種別:論文集(書籍)内論文   出版者・発行元:Elsevier  

    DOI: 10.1016/s0074-7742(09)88003-3

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  • テアニンの培養ドパミン神経およびグリア細胞系への作用

    染矢 恵, 竹島美香, 村田麻衣子, 宮崎育子, 浅沼幹人, 喜多大三

    九州栄養福祉大学研究紀要   5 ( 5 )   69 - 81   2008年12月

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    記述言語:日本語   掲載種別:研究論文(大学,研究機関等紀要)   出版者・発行元:九州栄養福祉大学  

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  • Dopamine Induces Supernumerary Centrosomes and Subsequent Cell Death through Cdk2 up-Regulation in Dopaminergic Neuronal Cells 査読

    Francisco J. Diaz-Corrales, Masato Asanuma, Ikuko Miyazaki, Ko Miyoshi, Nobutaka Hattori, Norio Ogawa

    Neurotoxicity Research   14 ( 4 )   295 - 305   2008年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    Aggregation of proteins in the centrosome is implicated in the pathophysiology of Parkinson&apos;s disease. However, the relevance of the centrosome in neurodegeneration is still obscure. Centrosome duplication is initiated by the cyclin E/cyclin-dependent kinase 2 (Cdk2) complex. The present study determined changes in cyclin E or Cdk2 expression and in the centrosomal structure in dopaminergic neuronal CATH.a cells exposed to 50, 100 and 150 mu M dopamine (DA) for 24 h. DA induced significant increase in Cdk2 protein and cyclin E protein, but not cyclin a mRNA. In DA-treated cells, the intense cyclin E- and Cdk2-immunofluorescence signals were co-localized around large and supernumerary centrosomes, and these two parameters of centrosome amplification were significantly increased compared with the control. Simultaneous co-treatment with DA and a Cdk2 inhibitor blocked centrosome amplification and enhanced cell viability. Our results demonstrated that DA could lead to cyclin E accumulation and Cdk2 up-regulation triggering supernumerary centrosomes and apoptotic cell death.

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  • 食品および食材に含まれる化学物質のモノアミン神経培養系に及ぼす作用に関する研究

    村田麻衣子, 竹島美香, 染矢 恵, 宮崎育子, 浅沼幹人, 喜多大三

    九州栄養福祉大学研究紀要   5 ( 5 )   55 - 67   2008年12月

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    記述言語:日本語   掲載種別:研究論文(大学,研究機関等紀要)   出版者・発行元:九州栄養福祉大学  

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  • Protective effects of interferon-gamma against methamphetamine-induced neurotoxicity (vol 177, pg 123, 2008) 査読

    Hiroaki Hozumi, Masato Asanuma, Ikuko Miyazaki, Saki Fukuoka, Yuri Kikkawa, Naotaka Kimoto, Yoshihisa Kitamura, Toshiaki Sendo, Taizo Kita, Yutaka Gomita

    Toxicology Letters   180 ( 3 )   231 - 231   2008年8月

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    記述言語:英語   出版者・発行元:ELSEVIER IRELAND LTD  

    DOI: 10.1016/j.toxlet.2008.06.864

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  • Effects of HMGB1 on ischemia-reperfusion injury in the rat heart 査読

    Susumu Oozawa, Shuji Mori, Toru Kanke, Hideo Takahashi, Keyue Liu, Yasuko Tomono, Masato Asanuma, Ikuko Miyazaki, Masahiro Nishibori, Shunji Sano

    Circulation Journal   72 ( 7 )   1178 - 1184   2008年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPANESE CIRCULATION SOC  

    Background Coronary ischemia-reperfusion (I/R) injury causes cardiomyocyte necrosis in a multi-step process that includes an inflammatory reaction. A recent study has suggested that high-mobility group box 1 (HMGB 1) is a late mediator of lethal sepsis and an early mediator of inflammation and necrosis following I/R injury. In the present study a neutralizing monoclonal antibody (mAb) for HMGB1 was used to clarify the role of HMGB 1 in cardiac I/R injury.
    Methods and Results Rats underwent 30 min of left coronary artery occlusion followed by 60 min reperfusion. An intravenous injection of anti-HMGB1 mAb or control IgG was administered just before reperfusion. The infarct size was enlarged in the anti-HMGB1 mAb group in comparison with the control group (p&lt;0.05). The treatment of anti-HMGB1 mAb significantly increased the plasma troponin-T and norepinephrine (NE) content in the heart in comparison with the control (p&lt;0.05). Moreover, the production of dihydroxyphenylglycol was reduced in the anti-HMGB1-treated group (p&lt;0.05).
    Conclusion This study shows for the first time the effects of treatment with neutralizing anti-HMGB1 mAb on I/R injury in the rat heart. The findings support the novel view that I/R-induced HMGB1 may be an important factor in the modulation of interstitial NE.

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  • Dopaminergic neuron-specific oxidative stress caused by dopamine itself 査読

    Ikuko Miyazaki, Masato Asanuma

    Acta Medica Okayama   62 ( 3 )   141 - 150   2008年6月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    Oxidative stress, including the reactive oxygen or nitrogen species generated in the enzymatical oxidation or auto-oxidation of an excess amount of dopamine, is thought to play an important role in dopaminergic neurotoxicity. Dopamine and its metabolites containing 2 hydroxyl residues exert cytotoxicity in dopaminergic neuronal cells, primarily due to the generation of highly reactive dopamine and DOPA quinones. Dopamine and DOPA quinones may irreversibly alter protein function through the formation of 5-cysteinyl-catechols on the proteins. Furthermore, the quinone formation is closely linked to other representative hypotheses such as mitochondrial dysfunction, inflammation, oxidative stress, and dysfunction of the ubiquitin-proteasome system, in the pathogenesis of neurodegenerative diseases. Therefore, pathogenic effects of the dopamine quinone have recently focused on dopaminergic neuron-specific oxidative stress. In this article, we primarily review recent studies on the pathogenicity of quinone formation, in addition to several neuroprotective approaches against dopamine quinone-induced dysfunction of dopaminergic neurons.

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  • Nonsteroidal anti-inflammatory drugs in experimental parkinsonian models and Parkinson's disease 査読

    Masato Asanuma, Ikuko Miyazaki

    Current Pharmacutical Design   14 ( 14 )   1428 - 1434   2008年5月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BENTHAM SCIENCE PUBL LTD  

    A number of experimental studies using parkinsonian models have revealed that nonsteroidal anti-inflammatory drugs (NSAIDs) have neuroprotective properties against dopaminergic neurotoxicity not only by their cyclooxygenase-inhibiting effect but also by other specific properties or some unknown pharmacological effects. This article reviews heterogeneous pharmacological properties of NSAIDs including inhibitory effect against nitric oxide synthesis, agonistic action for peroxisome proliferator-activated receptor or possible suppressive effects against dopamine quinone generation, and also reviews their neuroprotective effects in the experimental parkinsonian models and pathogenesis of Parkinson's disease. Several epidemiological studies recently clarified that the use of nonaspirin NSAIDs but not aspirin was associated with a lower prevalence of Parkinson's disease, in contrast with neuroprotective effects of aspirin in the experimental studies. It also discusses the discrepancy between results in the experimental parkinsonian models and epidemiological data in prevalence of Parkinson's disease on the effects of NSAIDs.

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  • Specific induction of PAG608 in cranial and spinal motor neurons of L-DOPA-treated parkinsonian rats 査読

    Masako Shimizu, Ikuko Miyazaki, Youichirou Higashi, Maria J. Eslava-Alva, Francisco J. Diaz-Corrales, Masato Asanuma, Norio Ogawa

    Neuroscience Research   60 ( 4 )   355 - 363   2008年4月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We identified p53-activated gene 608 (PAG608) as a specifically induced gene in striatal tissue of L-DOPA (100 mg/kg)-injected hemi-parkinsonian rats using differential display assay. In the present study, we further examined morphological distribution of PAG608 in the central nervous system of L-DOPA-treated hemi-parkinsonian rats. PAG608 expression was markedly induced in fibers and neuronal cells of the lateral globus pallidus and reticular thalamic nucleus adjacent to internal capsule, specifically in the parkinsonian side of L-DOPA-treated models. The protein was also constitutively expressed in motor neurons specifically in either side of the pontine nucleus and motor nuclei of trigeminal and facial nerves. Furthermore, L-DOPA-induced PAG608 expression on motor neurons in the contralateral side of the ventral horn of the spinal cord and the lateral corticospinal tract without cell loss. The specific induction of PAG608 6-48 h after L-DOPA injection in the extrapyramidal tracts, pyramidal tracts and corresponding lower motor neurons of the spinal cords suggests its involvement in molecular events in stimulated motor neurons. Taken together with the constitutive expression of PAG608 in the motor nuclei of cranial nerves, PAG608 may be a useful marker of stressed or activated lower motor neurons. © 2007 Elsevier Ireland Ltd and the Japan Neuroscience Society.

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  • Increased susceptibility to oxidant-mediated tissue injury and peritoneal fibrosis in acatalasemic mice 査読

    Naomi Fukuoka, Hitoshi Sugiyama, Tatsuyuki Inoue, Yoko Kikumoto, Kei-ichi Takiue, Hiroshi Morinaga, Kazushi Nakao, Yohei Maeshima, Masato Asanuma, Da-Hong Wang, Keiki Ogino, Noriyoshi Masuoka, Hirofumi Makino

    American Journal of Nephrology   28 ( 4 )   661 - 668   2008年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:KARGER  

    Background: Peritoneal fibrosis is a major complication leading to the loss of peritoneal function in patients undergoing peritoneal dialysis. However, the effect of catalase depletion on peritoneal fibrosis has not yet been investigated. Methods: The impact of catalase deficiency on progressive peritoneal fibrosis has been studied in homozygous acatalasemic mutant mice or control wild-type mice by intraperitoneal injection of chlorhexidine gluconate (CG) every other day for 14 days. Results: The CG injections resulted in a thicker peritoneal membrane, reflecting peritoneal fibrosis with accumulation of interstitial type I collagen, peritoneal deposition of lipid peroxidation products (4-hydroxy-2-nonenal and 4-hydroxy-2-hexenal), and an elevated level of 8-hydroxy-2&apos;-deoxyguanosine in peritoneal fluid in both mouse groups on day 14. The extent of these changes, however, was significantly higher in acatalasemic mice than in wild-type mice. The level of catalase activity remained low in the acatalasemic peritoneum without the compensatory upregulation of glutathione peroxidase, but with an insufficient upregulation of superoxide dismutase activity in CG-injected mice. Conclusions: Acatalasemia, therefore, exacerbates oxidant tissue injury and induces the peritoneum to develop irreversible fibrosis which is the most important complication of peritoneal dialysis. This study suggests that catalase plays a crucial role in the defense against oxidant-mediated peritoneal injury in a mouse peritoneal fibrosis model. Copyright (C) 2008 S. Karger AG, Basel.

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  • Protective effects of interferon-gamma against methamphetamine-induced neurotoxicity 査読

    Hiroaki Hozumi, Masato Asanuma, Ikuko Miyazaki, Saki Fukuoka, Yuri Kikkawa, Naotaka Kimoto, Yoshihisa Kitamura, Toshiaki Sendo, Taizo Kita, Yutaka Gomita

    Toxicology Letters   177 ( 2 )   123 - 129   2008年3月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Repeated injections of methamphetamine (METH) cause degeneration of striatal dopaminergic nerve terminals. In the present study, we examined the effects of interferon-gamma (IFN-gamma) on METH-induced striatal neurotoxicity in mice. Intraperitoneal injection of IFN-gamma before METH injection significantly prevented METH-induced reduction of striatal dopamine transporter (DAT)-positive signals and hyperthermia. Furthermore, intracerebroventricular injection of IFN-gamma before METH treatment markedly prevented METH-induced reduction of DAT. Interestingly, central IFN-gamma injection had no effect on METH-induced hyperthermia. In addition, IFN-gamma injected centrally after METH treatment, but not systemically, 1 h after the final METH injection significantly protected against METH-induced neurotoxicity. Our results suggest that IFN-gamma injected systemically or its related molecule protects against METH-induced neurotoxicity through intracerebral molecular pathways, while it can prevent METH-induced hyperthermia through different molecular events. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

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  • The roles of amino acid residues at positions 216 and 219 in the structural stability and metabolic functions of rat cytochrome P450 2D1 and 2D2 査読

    Shizuo Narimatsu, Kimio Kiryu, Rei Yonemoto, Manabu Yoshino, Mitsuko Kobatake, Daichi Kazamori, Saori Hagino, Kazufumi Masuda, Takashi Katsu, Masato Asanuma, Takuya Kumamoto, Tsutomu Ishikawa, Yoshihiko Funae, Shigeru Yamano, Nobumitsu Hanioka, Shinsaku Naito

    Chemico-Biological Interactions   172 ( 1 )   11 - 21   2008年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    We examined the effects of the mutual substitution of amino acid residues at positions 216 and 219 between rat CYP2D1 and CYP2D2 on their microsomal contents and enzymatic functions using a yeast cell expression system and 1-metloxy-N,N- diisopropyltryptamine (5-MeO-DIPT) as a substrate. CYP2D1 has amino acid residues, leucine and valine, at positions of 216 and 219, respectively, whereas CYP2D2 has phenylalanine and aspartic acid at the same positions. In reduced carbon monoxide-difference spectroscopic analysis, the substitution of Asp-219 of CYP2D2 by valine markedly increased a peak at 450 nm and concomitantly decreased a peak at 420 nm, while the replacement of Phe-216 of CYP2D2 with leucine gave no observable change. The double substitution of Phe-216 and Asp-219 by leucine and valine, respectively, yielded a typical CYP spectrum. The substitution of Val-219 of CYP2D1 by aspartic acid decreased the CYP content to one-half, whereas the replacement of Leu-216 with phenylalanine did not have any effect. The double substitution of Leu-216 and Val-219 of CYP2D1 by phenylalanine and aspartic acid, respectively, diminished the CYP content by 90%. CYP2D1 catalyzed both 5-MeO-DIPT N-deisopropylation and O-demethylation at relatively low levels, while CYP2D2 catalyzed 5-MeO-DIPT O-demethylation efficiently. The substitution of the amino acid at position 216 substantially increased 5-MeO-DIPT oxidation activities of the two CYP2D enzymes. The replacement of the amino acid at position 219 increased the 5-MeO-DIPT O- and N-dealkylation activities of CYP2D1, whereas it decreased the 5-MeO-DIPT O-demethylation activity of CYP2D2. These results indicate that amino acid residues at positions 216 and 219 have important roles in the enzymatic functions of rat CYPD1 and CYP2D2. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

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  • Oxidation of 5-methoxy-N,N-diisopropyltryptamine in rat liver microsomes and recombinant cytochrome P450 enzymes 査読

    Shizuo Narimatsu, Rei Yonemoto, Kazufumi Masuda, Takashi Katsu, Masato Asanuma, Tooru Kamata, Munehiro Katagi, Hitoshi Tsuchihashi, Takuya Kumamoto, Tsutomu Ishikawa, Shinsaku Naito, Shigeru Yamano, Nobumitsu Hanioka

    Biochemical Pharmacology   75 ( 3 )   752 - 760   2008年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    The oxidative metabolism of 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT), a tryptamine-type designer drug, was studied using rat liver microsomal fractions and recombinant cytochrome P450 (CYP) enzymes. 5-MeO-DIPT was biotransformed mainly into a side-chain N-deisopropylated metabolite and partially into an aromatic ring O-demethylated metabolite in liver microsomal fractions from untreated rats of both sexes. This metabolic profile is different from our previous findings in human liver microsomal fractions, in which the aromatic ring O-demethylation was the major pathway whereas the side-chain N-deisopropylation was minor [Narimatsu S, Yonemoto R, Saito K, Takaya K, Kumamoto T, Ishikawa T, et al. oxidative metabolism of 5-methoxy-N,N-diisopropyltryptamine (Foxy) by human liver microsomes and recombinant cytochrome P450 enzymes. Biochem Pharmacol 2006;71:1377-85]. Kinetic and inhibition studies indicated that the side-chain N-dealkylation is mediated by CYP2C11 and CYP3A2, whereas the aromatic ring O-demethylation is mediated by CYP2D2 and CYP2C6 in untreated male rats. Pretreatment of male rats with p-naphthoflavone (BNF) produced an aromatic ring 6-hydroxylated metabolite. Recombinant rat and human CYP1A1 efficiently catalyzed 5-MeO-DIPT 6-hydroxylation under the conditions used. These results provide valuable information on the metabolic fate of 5-MeO-DIPT in rats that can be used in the toxicological study of this designer drug. (c) 2007 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.bcp.2007.09.019

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  • 小胞外過剰ドパミンによるドパミン神経障害における共通因子としてのキノン体生成 招待 査読

    宮崎育子, 浅沼幹人, Diaz-Corrales FJ, 三好 耕, 小川紀雄

    岡山医学会雑誌   119 ( 1 )   235 - 239   2008年1月

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    記述言語:日本語   掲載種別:研究論文(その他学術会議資料等)   出版者・発行元:岡山医学会  

    DOI: 10.4044/joma.119.235

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    その他リンク: http://ousar.lib.okayama-u.ac.jp/13216

  • Preventing effects of a novel anti-parkinsonian agent zonisamide on dopamine quinone formation 査読

    Masato Asanuma, Ikuko Miyazaki, Francisco J. Diaz-Corrales, Ko Miyoshi, Norio Ogawa, Miho Murata

    Neuroscience Research   60 ( 1 )   106 - 113   2008年1月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    The neurotoxicity of dopamine (DA) quinones as dopaminergic neuron-specific oxidative stress is considered to play a role in the pathogenesis and/or progression of Parkinson's disease (PD), since DA quinones conjugate with several key PD pathogenic molecules (e.g., tyrosine hydroxylase, alpha-synuclein and parkin) to form protein-bound quinone (quinoprotein) and consequently inhibit their functions. Zonisamide (ZNS) is used as an anti-epileptic agent but also improved the cardinal symptoms of PD in recent clinical trials in Japan. To evaluate the effects of ZNS on excess cytosolic free DA-induced quinone toxicity, we examined changes in DA quinone-related indices after ZNS treatment both in in vitro cell-free system and in cultured cells. Co-incubation of DA and ZNS in a cell-free system caused conversion of DA to stable melanin via formation of DA-semiquinone radicals and DA chrome. Long-term (5 days) treatment with ZNS decreased quinoprotein and increased DA/DOPA chromes in dopaminergic CATH.a cells. ZNS significantly inhibited quinoprotein formation induced by treatment with tetrahydrobiopterin and ketanserin that elevate cytosolic free DA in the cells. Our results suggest that the novel anti-parkinsonian agent ZNS possesses preventing effects against DA quinone formation induced by excess amount of cytosolic DA outside the synaptic vesicles. (c) 2007 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

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  • メタンフェタミン神経毒性発現に関する研究の新展開 査読

    喜多大三, 竹島美香, Wagner GC, 穂積宏彰, 宮崎育子, 浅沼幹人

    日本神経精神薬理学会雑誌   28 ( 2 )   49 - 61   2008年

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    担当区分:最終著者   掲載種別:研究論文(学術雑誌)  

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  • 食品容器および食器より溶出する化学物質のドパミン神経障害性に関する研究─ビスフェノールAの培養ドパミン神経系への作用─

    喜多大三, 竹島美香, 田中弓子, 宮崎育子, 浅沼幹人

    九州栄養福祉大学研究紀要   4 ( 4 )   89 - 97   2007年12月

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    記述言語:日本語   出版者・発行元:九州栄養福祉大学  

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  • Protective effects of metallothionein against dopamine quinone-induced dopaminergic neurotoxicity 査読

    Ikuko Miyazaki, Masato Asanuma, Hiroaki Hozumi, Ko Miyoshi, Norio Sogawa

    FEBS Letters   581 ( 25 )   5003 - 5008   2007年10月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Dopamine (DA) quinone as DA neuron-specific oxidative stress conjugates with cysteine residues in functional proteins to form quinoproteins. Here, we examined the effects of cysteine-rich metal-binding proteins, metallothionein (NIT)-1 and -2, on DA quinone-induced neurotoxicity. NIT quenched DA semiquinones in vitro. In dopaminergic cells, DA exposure increased quinoproteins and decreased cell viability; these were ameliorated by pretreatment with MT-inducer zinc. Repeated L-DOPA administration markedly elevated striatal quinoprotein levels and reduced the DA nerve terminals specifically on the lesioned side in NIT-knockout parkinsonian mice, but not in wild-type mice. Our results suggested that intrinsic NIT protects against L-DOPA-induced DA quinone neurotoxicity in parkinsonian mice by its quinone-quenching property. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.febslet.2007.09.046

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  • Common anti-inflammatory drugs are potentially therapeutic for Parkinson's disease? 招待 査読

    Masato Asanuma, Ikuko Miyazaki

    Experimental Neurology   206 ( 2 )   172 - 178   2007年8月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE  

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  • 5-Methoxy-N,N-diisopropyltryptamine (Foxy), a selective and high affinity inhibitor of serotonin transporter 査読

    C. Sogawa, N. Sogawa, J. Tagawa, A. Fujino, K. Ohyama, M. Asanuma, M. Funada, S. Kitayama

    Toxicology Letters   170 ( 1 )   75 - 82   2007年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    5-Methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) is a synthetic orally active hallucinogenic tryptamine derivative, known also as Foxy or Foxy methoxy. However, few studies have examined its effects in vitro. In the present study, we investigated the actions of 5-MeO-DIPT against monoamine neurotransmitter transporters, including the transporters for dopamine (DAT), norepinephrine (NET), and serotonin (SERT), using COS-7 cells heterologously expressing these transporters and rat brain synaptosomes. 5-MeO-DIPT specifically inhibited the uptake of [H-3]serotonin (5-HT) by the SERT-expressing COS-7 cells and rat striatal synaptosomes in a high affinity manner at concentrations similar to those for cocaine. The effect was reversible and competitive. 5-MeO-DIPT failed to stimulate reverse transport of [H-3]5-HT through SERT, while it prevented the releasing action of methamphetamine. 5-MeO-DIPT induced cell toxicity at high concentrations in COS-7 cells, and it was not influenced by the expression of SERT. These results demonstrated that 5-MeO-DIPT acts as a competitive SERT inhibitor and has an inability to cause reverse transport, underlying its serotonergic actions. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

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  • Suppression of p53-activated gene, PAG608, attenuates methamphetamine-induced neurotoxicity 査読

    Masato Asanuma, Ikuko Miyazaki, Youichirou Higashi, Francisco J. Diaz-Corrales, Masako Shimizu, Ko Miyoshi, Norio Ogawa

    Neuroscience Letters   414 ( 3 )   263 - 267   2007年3月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    The p53-activated gene 608 (PAG608) is a proapoptotic gene activated and regulated by p53 expression in oxidative stress-induced apoptosis of neuronal cells. In this study, we determined the role of PAG608 in methamphetamine-induced neurotoxicity. Treatment of mouse dopaminergic CATH.a cells with 2 mM methamphetamine increased PAG608 expression at 3 h followed by increase in phosphorylated p53 expression. Transient transfection of PAG608 antisense cDNA or RNA interference using PAG608 small interfering RNA significantly attenuated the dose-dependent decrease in cell viability of CATH.a cells by methamphetamine (1-4 mM) exposure. In monoaminergic neuronal B65 cells, which contain serotonin rather than dopamine, methamphetamine-induced cell death was also significantly but partially protected by transient transfection of PAG608 antisense cDNA. Furthermore, cell death of PC 12 cells produced by methamphetamine (1-5 mM) was almost completely prevented by stable expression of PAG608 antisense cDNA, compared with significant reduction of cell viability in control PC12 cells. Our results showed that suppression of PAG608 using transient and stable transfection with PAG608 anti sense cDNA or small interfering RNA attenuates methamphetamine-induced death of various monoaminergic neuronal cells, suggesting that methamphetamine neurotoxicity in monoaminergic cells is related, at least in part, to induction of PAG608 expression. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

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  • Characterization of pericentrin isoforms in vivo 査読

    Ko Miyoshi, Masato Asanuma, Ikuko Miyazaki, Shinsuke Matsuzaki, Masaya Tohyama, Norio Ogawa

    Biochemical and Biophysical Research Communications   351 ( 3 )   745 - 749   2006年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE  

    Pericentrin was first identified as a mouse centrosomal protein and is now referred to as pericentrin A. A larger homologous protein in humans with a C-terminal calmodulin-binding domain was later identified as pericentrin B. Pericentrin has been shown to be one of the key components in ciliogenesis.. but in vivo pericentrin products have remained ambiguous. Here we characterized pericentrin isoforms in mice. Two pericentrin transcripts of 9.5 and 6.9 kb were recognized on the mouse tissue Northern blots, while a cRNA probe for a 5'-terminal sequence shared by pericentrin A and B failed to hybridize to the 6.9-kb message. Two pericentrin cDNAs were identified, which encoded pericentrin B and a novel isoform, pericentrin S, sharing with pericentrin B a C-terminal calmodulin-binding motif. Three pericentrin proteins of 360, 255, and 250 kDa revealed by immunoprecipitation analysis were thought to correspond to pericentrin B, pericentrin S, and an unknown N-terminal product. (c) 2006 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.bbrc.2006.10.101

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  • Involvement of STAT3 in bladder smooth muscle hypertrophy following bladder outlet obstruction 査読

    Osamu Fujita, Masato Asanuma, Teruhiko Yokoyama, Ikuko Miyazaki, Norio Ogawa, Hiromi Kumon

    Acta Medica Okayama   60 ( 6 )   299 - 309   2006年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    We examined the involvement of the signal transducer and activator of transcription 3 (STAT3) in bladder outlet obstruction (BOO)-induced bladder smooth muscle hypertrophy using a rat in vivo and in vitro study. BOO induced increases in bladder weight and bladder smooth muscle thickness I week after the operation. By using antibody microarrays, 64 of 389 proteins blotted on the array met our selection criteria of an INR value between &gt;= 2.0 and &lt;= 0.5. This result revealed up-regulation of transcription factors, cell cycle regulatory proteins, apoptosis-associated proteins and so on. On the other hand, down-regulation (INR value &lt;= 0.5) of proteins was not found. In a profiling study, we found an increase in the expression of STAT3. A significant increase in nuclear phosphorylated STAT3 expression was confirmed in bladder smooth muscle tissue by immunohistochemistry and Western blot analysis. Cyclical stretch-relaxation (I Hz) at 120% elongation significantly increased the expression of STAT3 and of alpha-smooth muscle actin in primary cultured bladder smooth muscle cells. Furthermore, the blockade of STAT3 expression by the transfection of STAT3 small interfering RNA (siRNA) significantly prevented the stretch-induced increase in alpha-smooth muscle actin expression. These results suggest that STAT3 has an important role in the induction of bladder smooth muscle hypertrophy.

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  • Molecular basis of 6-hydroxydopamine-induced caspase activations due to increases in oxidative stress in the mouse striatum 査読

    Ken-ichi Tanaka, Norio Ogawa, Masato Asanuma

    Neuroscience Letters   410 ( 2 )   85 - 89   2006年12月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    To clarify the possible role of in the in vivo toxic effects of 6-hydroxydopamine (6-OHDA), especially caspase activations, we examined its effects on striatal lipid peroxidation (LPO) and caspase activations in 6-OHDA-lesioned mice. Both dopamine (DA) levels and DA turnover were significantly changed by the 6-OHDA i.c.v. injection compared with the pre-injection level in the striatum. In addition, the striatal glutathione (GSH) content fluctuated and was significantly decreased both at 3 and 14 days after 6-OHDA i.e.v. injection. Moreover, superoxide dismutase (SOD) activity at 7 days after 6-OHDA i.c.v. injection was transiently and significantly increased compared with the pre-injection level. The levels of thiobarbituric acid-reactive substances (TBA-RS) were significantly increased at 1, 3 and 14 days. 6-OHDA significantly increased the activities of all three caspases, except for the caspase-3 activity at 7 days throughout the experimental period compared with the pre-injection level. In conclusion, 6-OHDA-induced dopaminergic dysfunction is mainly due to caspase activations by increases in oxidative stress in the mouse striatum. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.neulet.2006.08.021

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  • Nonsteroidal anti-inflammatory drugs in Parkinson's disease: possible involvement of quinone formation 査読

    Masato Asanuma, Ikuko Miyazaki

    Expert Review of Neurotherapeutics   6 ( 9 )   1313 - 1325   2006年9月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   出版者・発行元:EXPERT REVIEWS  

    It has been revealed that nonsteroidal anti-inflammatory drugs (NSAIDs) have neuroprotective properties based not only on their cyclooxygenase-inhibitory action, but also on other properties including their inhibitory effects on the synthesis of nitric oxide radicals and agonistic action for peroxisome proliferator-activated receptor gamma, in addition to some as yet unknown properties. Recently, a number of experimental and clinical studies have examined the neuroprotective effects of NSAIDs on the pathogenesis of several neurodegenerative diseases, including Parkinson's disease. In this article, various pharmacological effects of NSAIDs (except for their cyclooxygenase-inhibitory action) are reviewed, and possible neuroprotective effects of NSAIDs on Parkinson's disease are discussed. The neurotoxicity of dopamine quinones, or DOPA quinones, has recently received attention as a dopaminergic neuron-specific oxidative stress that is known to play a role in the pathogenesis of Parkinson's disease and neurotoxin-induced parkinsonism. NSAIDs inhibit prostaglandin H synthase, thus suppressing dopamine oxidation and subsequent dopamine quinone formation. Therefore, this article also reviews possible suppressive effects of some NSAIDs against dopamine quinone generation. Expert Rev. Neurotherapeutics 6(9), 1313-1325 (2006)

    DOI: 10.1586/14737175.6.9.1313

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  • Embryonic expression of pericentrin suggests universal roles in ciliogenesis 査読

    Ko Miyoshi, Kazunari Onishi, Masato Asanuma, Ikuko Miyazaki, Francisco J. Diaz-Corrales, Norio Ogawa

    Development Genes and Evolution   216 ( 9 )   537 - 542   2006年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    Pericentrin (Pcnt) is a giant coiled-coil protein known to mediate microtubule organization. It has been recently reported that mitosis-specific centrosomal anchoring of gamma tubulin complexes by Pcnt acts to control mitotic spindle organization, though little is known about the in vivo expression of Pcnt. In this study, we investigated Pcnt expression in mouse embryos. In situ hybridization analysis revealed preferential expression of Pcnt in quiescent G(0) phase cells throughout the embryo with an unexpectedly low expression level in proliferating cells, suggesting that Pcnt might not play an important role in mitotic proliferation. Immunofluorescence analysis confirmed preferential expression of the Pcnt protein in G(0) phase cells. Moreover, Pcnt was shown to be localized to the base of primary cilia in multiple embryonic tissues, in agreement with a recent study demonstrating the involvement of Pcnt in primary cilia formation using cultured mammalian cells.

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  • Oxidative metabolism of 5-methoxy-N,N-diisopropyltryptamine (Foxy) by human liver microsomes and recombinant cytochrome P450 enzymes 査読

    Shizuo Narimatsu, Rei Yonemoto, Keita Saito, Kazuo Takaya, Takuya Kumamoto, Tsutomu Ishikawa, Masato Asanuma, Masahiko Funada, Kimio Kiryu, Shinsaku Naito, Yuzo Yoshida, Shigeo Yamamoto, Nobumitsu Hanioka

    Biochemical Pharmacology   71 ( 9 )   1377 - 1385   2006年4月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.bcp.2006.01.015

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  • Centrosome overduplication induced by rotenone treatment affects the cellular distribution of p53 tumor suppressor protein in the neuroblastoma B65 cell line

    Francisco J Diaz-Corrales, Masato Asanuma, Ikuko Miyazaki, Ko Miyoshi, Norio Ogawa

    Psychiatry and Clinical Neurosciences   60   S18 - S26   2006年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Methamphetamine‐induced dopaminergic neurotoxicity is regulated by quinone formation‐related molecules 査読

    Ikuko Miyazaki, Masato Asanuma, Francisco J. Diaz‐Corrales, Masaya Fukuda, Kiyoyuki Kitaichi, Ko Miyoshi, Norio Ogawa

    The FASEB Journal   20 ( 3 )   571 - 573   2006年3月

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    担当区分:責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1096/fj.05-4996fje

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  • 腹膜透析におけるラジカル分子特異的測定と腹膜硬化症早期診断マーカーの確立.

    杉山 斉, 菊本陽子, 浅沼幹人, 平松 信, 槇野博史

    腎臓   29 ( 2 )   112 - 117   2006年

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    記述言語:日本語   掲載種別:研究論文(その他学術会議資料等)  

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  • ドパミン受容体アゴニストによるドパミンニューロン死の制御. 招待

    浅沼幹人

    Clinical Neuroscience   23 ( 12 )   1342 - 1343   2005年12月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • 酸化ストレスによる神経障害と神経保護療法─ドパミン神経特異的酸化ストレスとしてのキノン体毒性. 招待

    浅沼幹人, 小川紀雄

    医学のあゆみ   215 ( 10 )   785 - 792   2005年12月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • L-DOPA treatment from the viewpoint of neuroprotection 査読

    Norio Ogawa, Masato Asanuma, Ikuko Miyazaki, Francisco J. Diaz-Corrales, Ko Miyoshi

    Journal of Neurology   252 ( S4 )   iv23 - iv31   2005年10月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1007/s00415-005-4006-7

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  • Prednisolone Inhibits Proliferation of Cultured Pulmonary Artery Smooth Muscle Cells of Patients With Idiopathic Pulmonary Arterial Hypertension 査読 国際誌

    Aiko Ogawa, Kazufumi Nakamura, Hiromi Matsubara, Hideki Fujio, Tetsuya Ikeda, Kaoru Kobayashi, Ikuko Miyazaki, Masato Asanuma, Katsumasa Miyaji, Daiji Miura, Kengo Fukushima Kusano, Hiroshi Date, Tohru Ohe

    Circulation   112 ( 12 )   1806 - 1812   2005年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Ovid Technologies (Wolters Kluwer Health)  

    <bold>
    <italic>Background—</italic>
    </bold>
    Idiopathic pulmonary arterial hypertension (IPAH) is associated with proliferation of smooth muscle cells (SMCs) in small pulmonary arteries. There is no therapy that specifically inhibits SMC proliferation. Recent studies reported that prednisolone (PSL) inhibits the postangioplasty proliferation of SMCs in atherosclerotic arteries. In this study, we tested the hypothesis that PSL has antiproliferative effects on pulmonary artery SMCs of patients with IPAH.




    <bold>
    <italic>Methods and Results—</italic>
    </bold>
    Pulmonary artery SMCs were harvested from the pulmonary arteries of 6 patients with IPAH who underwent lung transplantation. Control SMCs were obtained from 5 patients with bronchogenic carcinoma who underwent lung lobectomy. After incubation in the presence of platelet-derived growth factor (PDGF), PSL was added at different concentrations and cell proliferation was assessed by
    3
    H-thymidine incorporation. PSL (2×10
    −4
    and 2×10
    −3
    mol/L) significantly inhibited PDGF-stimulated proliferation (
    <italic>P</italic>
    &lt;0.05) of SMCs from patients with IPAH but did not affect cell viability of SMCs, as confirmed by trypan blue staining. In cell cycle analysis using a microscope-based multiparameter laser scanning cytometer, PSL inhibited the progression of SMCs from G
    0
    /G
    1
    to the S phase. This inhibition was associated with increased p27 expression level. PSL (2×10
    −4
    mol/L) also inhibited PDGF-induced SMC migration.




    <bold>
    <italic>Conclusions—</italic>
    </bold>
    Our results indicate that PSL has an antiproliferative effect on cultured SMCs of pulmonary arteries from patients with IPAH and suggest that PSL may be potentially useful therapeutically in patients with IPAH.

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  • Dopamine agonist pergolide prevents levodopa-induced quinoprotein formation in Parkinsonian striatum and shows quenching effects on dopamine-semiquinone generated in vitro 査読

    Ikuko Miyazaki, Masato Asanuma, Francisco J. Diaz-Corrales, Ko Miyoshi, Norio Ogawa

    Clinical Neuropharmacology   28 ( 4 )   155 - 160   2005年7月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The neurotoxicity of dopamine (DA) quinones that appears in dopaminergic neuron-specific oxidative stress has recently been shown to play a role in the pathogenesis and/or progression of Parkinson disease. To clarify the effects of a DA agonist, pergolide, on the levodopa-induced elevation of quinones, the authors examined, striatal changes in quinoprotein using a hemi-parkinsonian mouse model. The level of striatal quinoprotein was significantly elevated specifically on the parkinsonian side, but not on the control side, after repeated levodopa administration. This levodopa-induced increase in striatal quinoprotein was almost completely suppressed by adjunctive administration with pergolide on the lesioned side. Furthermore, it was clarified that pergolide scavenged DA-semiquinones generated in vitro in a dose-dependent manner. These suppressive and quenching effects of pergolide against cytotoxic DA quinones may play a key role in its neuroprotective mechanism in the parkinsonian brain. Copyright © 2005 by Lippincott Williams &amp
    Wilkins.

    DOI: 10.1097/01.wnf.0000175523.33334.24

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  • 薬物依存・毒性発現にかかわる分子の分子生物学的検索法─網羅的プロファイリングを中心に. 招待

    浅沼幹人, 宮崎育子

    日本薬理学雑誌   126 ( 1 )   30 - 34   2005年7月

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    担当区分:筆頭著者, 責任著者   記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:公益社団法人 日本薬理学会  

    従来,ある事象に関与すると考えられる分子の同定は,既知の関与分子と連関のあると報告された分子の発現の増減を一つ一つ確認していく,あるいは既知の分子と結合するタンパクをFar-Western法,two-hybrid法などで見つけていくという手法が用いられてきた.しかし,これではある事象に関与する既知の分子機構の枠を越えた新たな分子機構を発見したり,新たな観点に基づく分子仮説を提唱できるような発見をすることは難しかった.これに対して,10-20年前から,ある事象で発現が増減しているmRNAをスクリーニングする手法として,differential display法とそれに続くライブラリースクリーニング,RACE法などが広く用いられ,キット化された.さらに,近年1,000-10,000ものcDNA断片をブロットしたナイロン・グラス・プラスチックcDNAアレイが市販あるいはオーダーメードされるようになり,様々な生物学的・病理学的事象で発現が変化している遺伝子の網羅的検索が可能になった.近年のポストゲノムの潮流と遺伝子とタンパクの発現の乖離から,二次元電気泳動などによる発現タンパクのスクリーニング,さらに抗体がブロットされた抗体アレイを用いてのタンパク発現の網羅的検索も可能になってきている.しかし,これらの網羅的検索法はそれぞれ長所および短所,限界を有しており,目的に応じて使い分ける必要がある.本稿では,主に覚醒剤の急性毒性発現にかかわる遺伝子・分子の分子生物学的網羅的検索法の自検例を交えて,それらの長所・短所について概説する.<br>

    DOI: 10.1254/fpj.126.30

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  • Pramipexole has ameliorating effects on levodopa-induced abnormal dopamine turnover in parkinsonian striatum and quenching effects on dopamine-semiquinone generatedin vitro 査読

    Masato Asanuma, Ikuko Miyazaki, Francisco J. Diaz-Corrales, Masako Shimizu, Ken-ichi Tanaka, Norio Ogawa

    Neurological Research   27 ( 5 )   533 - 539   2005年7月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Maney Publishing  

    DOI: 10.1179/016164105x22093

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  • Common anti-apoptotic roles of parkin and α-synuclein in human dopaminergic cells 査読

    Yutaka Machida, Tomoki Chiba, Atsushi Takayanagi, Yoshikazu Tanaka, Masato Asanuma, Norio Ogawa, Akihiko Koyama, Takeshi Iwatsubo, Shosuke Ito, Poul Hening Jansen, Nobuyoshi Shimizu, Keiji Tanaka, Yoshikuni Mizuno, Nobutaka Hattori

    Biochemical and Biophysical Research Communications   332 ( 1 )   233 - 240   2005年6月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.bbrc.2005.04.124

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  • Rotenone induces aggregation of γ-tubulin protein and subsequent disorganization of the centrosome: Relevance to formation of inclusion bodies and neurodegeneration 査読

    Francisco J. Diaz-Corrales, Masato Asanuma, Ikuko Miyazaki, Ko Miyoshi, Norio Ogawa

    Neuroscience   133 ( 1 )   117 - 135   2005年1月

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    担当区分:責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.neuroscience.2005.01.044

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  • Direct evidence for expression of dopamine receptors in astrocytes from basal ganglia 査読

    Ikuko Miyazaki, Masato Asanuma, Francisco J. Diaz-Corrales, Ko Miyoshi, Norio Ogawa

    Brain Research   1029 ( 1 )   120 - 123   2004年12月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Expression of dopamine receptors (DA-Rs) in astrocytes was examined in vitro and in vivo using primary cultured astrocytes and brain slices from rat basal ganglia. Astrocytes from basal ganglia expressed DA D1-, D3-, D4- and D5-receptors and D4-mediated signal transduction in response to DA, suggesting possible involvement of astrocytes in the pharmacological action of atypical antipsychotic drugs and in DA response in some neurological diseases. © 2004 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.brainres.2004.09.014

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  • Quinone formation as dopaminergic neuron-specific oxidative stress in the pathogenesis of sporadic Parkinson's disease and neurotoxin-induced parkinsonism.

    Masato Asanuma, Ikuko Miyazaki, Francisco J Diaz-Corrales, Norio Ogawa

    Acta Medica Okayama   58 ( 5 )   221 - 233   2004年10月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   出版者・発行元:Okayama University Medical School  

    <p>Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by dopaminergic neuron-specific degeneration in the substantia nigra. A number of gene mutations and deletions have been reported to play a role in the pathogenesis of familial PD. Moreover, a number of pathological and pharmacological studies on sporadic PD and dopaminergic neurotoxin-induced parkinsonism have hypothesized that mitochondrial dysfunction, inflammation, oxidative stress, and dysfunction of the ubiquitin-proteasome system all play important roles in the pathogenesis and progress of PD. However, these hypotheses do not yet fully explain the mechanisms of dopaminergic neuron-specific cell loss in PD. Recently, the neurotoxicity of dopamine quinone formation by auto-oxidation of dopamine has been shown to cause specific cell death of dopaminergic neurons in the pathogenesis of sporadic PD and dopaminergic neurotoxin-induced parkinsonism. Furthermore, this quinone formation is closely linked to other representative hypotheses in the pathogenesis of PD. In this article, we mainly review recent studies on the neurotoxicity of quinone formation as a dopaminergic neuron-specific oxidative stress and its role in the etiology of PD, in addition to several neuroprotective approaches against dopamine quinone-induced toxicity.</p>

    DOI: 10.18926/AMO/32105

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  • Specific Gene Expression and Possible Involvement of Inflammation in Methamphetamine-Induced Neurotoxicity 査読

    Masato Asanuma, Ikuko Miyazaki, Youichirou Higashi, Takeshi Tsuji, Norio Ogawa

    Annals of the New York Academy of Sciences   1025 ( 1 )   69 - 75   2004年10月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1196/annals.1316.009

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  • パーキンソン病における細胞死の機序. 招待

    小川紀雄, 浅沼幹人, 三好 耕

    日本臨床   62 ( 9 )   1629 - 1634   2004年9月

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    掲載種別:研究論文(学術雑誌)  

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  • Expression of metallothionein-III and cell death in differentiated catecholaminergic neuronal cells 査読

    Youichirou Higashi, Masato Asanuma, Ikuko Miyazaki, Norio Ogawa

    Neurological Research   26 ( 6 )   671 - 676   2004年9月

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    担当区分:責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Informa UK Limited  

    DOI: 10.1179/016164104225015895

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  • Metallothioneins and neurodegenerative diseases 査読

    Isao Hozumi, Masato Asanuma, Mitsunori Yamada, Yoko Uchida

    Journal of Health Science   50 ( 4 )   323 - 331   2004年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PHARMACEUTICAL SOC JAPAN  

    A symposium on the clinical aspects of metallothioneins (MTs) in neurodegenerative diseases was held at the 2003 Society of Metallothionein Meeting in Gifu, Japan. The objectives of the symposium were to review and speculate on the potential roles of MTs, especially MT-3 in neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and spinocerebellar degeneration (SCD). Dr. Uchida discussed the controversial problem regarding the expression of MT-3 in AD brains. Dr. Asanuma addressed the function of MTs in the progression of PD and Dr. Hozumi described the therapeutic potential of MTs for ALS, while Dr. Yamada provided immunohistochemical findings of MT-3 in SCD for the first time. Although there are still controversial problems on MTs, this review provides proof that MTs are promising potential therapeutic targets for therapy for some neurodegenerative diseases.

    DOI: 10.1248/jhs.50.323

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  • Molecular Basis of Anti-Apoptotic Effect of Immunophilin Ligands on Hydrogen Peroxide–Induced Apoptosis in Human Glioma Cells 査読

    Ken-ichi Tanaka, Masato Asanuma, Norio Ogawa

    Neurochemical Research   29 ( 8 )   1529 - 1536   2004年8月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1023/b:nere.0000029565.92587.25

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  • Parkin attenuates manganese‐induced dopaminergic cell death 査読

    Youichirou Higashi, Masato Asanuma, Ikuko Miyazaki, Nobutaka Hattori, Yoshikuni Mizuno, Norio Ogawa

    Journal of Neurochemistry   89 ( 6 )   1490 - 1497   2004年6月

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    担当区分:責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1111/j.1471-4159.2004.02445.x

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    その他リンク: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/j.1471-4159.2004.02445.x

  • DISC1 localizes to the centrosome by binding to kendrin 査読

    Ko Miyoshi, Masato Asanuma, Ikuko Miyazaki, Francisco J. Diaz-Corrales, Taiichi Katayama, Masaya Tohyama, Norio Ogawa

    Biochemical and Biophysical Research Communications   317 ( 4 )   1195 - 1199   2004年5月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.bbrc.2004.03.163

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  • 酸化ストレスとミトコンドリア機能障害,炎症反応.―孤発性パーキンソン病とドパミン神経毒研究から得たもの. 招待

    浅沼幹人

    内科   93 ( 4 )   611 - 615   2004年4月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • Neuroprotective Effects of Nonsteroidal Anti-inflammatory Drugs on Neurodegenerative Diseases 査読

    M. Asanuma, I. Miyazaki, N. Ogawa

    Current Pharmaceutical Design   10 ( 6 )   695 - 700   2004年2月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Bentham Science Publishers Ltd.  

    DOI: 10.2174/1381612043453072

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  • Parkinson病薬物治療の将来 ―進行抑制薬実現の可能性. 招待

    小川紀雄, 浅沼幹人, 田中健一

    医学のあゆみ   208 ( 6 )   583 - 588   2004年2月

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    掲載種別:研究論文(学術雑誌)  

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  • 実験的パーキンソニズムに使われる薬剤.〜MPTP,6-ヒドロキシドパミンならびにロテノン〜. 招待

    浅沼幹人, 宮崎育子, 小川紀雄

    医薬ジャーナル   40 ( 1 )   111 - 116   2004年1月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • Rotenone induces disassembly of the Golgi apparatus in the rat dopaminergic neuroblastoma B65 cell line 査読

    Francisco J. Diaz-Corrales, Masato Asanuma, Ikuko Miyazaki, Norio Ogawa

    Neuroscience Letters   354 ( 1 )   59 - 63   2004年1月

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    担当区分:責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.neulet.2003.09.059

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  • 遺伝子改変によるパーキンソン病モデル. 招待

    浅沼幹人, 宮崎育子

    脳の科学   292 ( 2004年増刊号 )   165 - 170   2004年

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    担当区分:筆頭著者, 責任著者   掲載種別:論文集(書籍)内論文  

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  • β遮断薬による心不全・不整脈治療の基礎と臨床ーカルベジロールを中心としてーβ遮断薬と酸化ストレス. 査読

    中村一文, 垣下幹夫, 草野研吾, 三浦 綾, 久松研一, 永瀬 聡, 森田 宏, 斉藤博則, 江森哲郎, 浅沼幹人, 小川紀雄, 宮崎正博, 中村陽一, 松原広己, 伏見和郎, 豊國伸哉, 大江 透

    心電図   24 ( 1 )   15 - 21   2004年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:(一社)日本不整脈心電学会  

    欧米における大規模臨床試験の結果は,β遮断薬が慢性心不全の生命予後改善のみならず,突然死も有意に抑制することを明らかにした.しかし,患者背景の異なる我が国における,β遮断薬の有効性は必ずしも明確ではない.そこで,著者等の自験例を基に,致死性不整脈患者或いは慢性心不全患者に対するカルベジロールを中心としたβ遮断薬の予後に対する影響及び突然死予防効果,その機序について検討した

    DOI: 10.5105/jse.24.15

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  • Direct Evidence for Increased Hydroxyl Radicals in Angiotensin II-induced Cardiac Hypertrophy through Angiotensin II Type 1a Receptor 査読 国際誌

    Mikio Kakishita, Kazufumi Nakamura, Masato Asanuma, Hiroshi Morita, Hironori Saito, Kengo Kusano, Yoichi Nakamura, Tetsuro Emori, Hiromi Matsubara, Takeshi Sugaya, Norio Ogawa, Tohru Ohe

    Journal of Cardiovascular Pharmacology   42 ( Suppl 1 )   S67 - S70   2003年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Ovid Technologies (Wolters Kluwer Health)  

    Oxidative stress is known to contribute to numerous cardiac disease processes. However, the contribution of reactive oxygen species to cardiac hypertrophy has not yet been fully investigated. The aim of the present study was therefore to determine whether levels of reactive oxygen species were increased in angiotensin II-induced cardiac hypertrophy. We continuously administered angiotensin II (1.1 mg/kg per day) into wild-type and angiotensin II type-1a receptor knockout mice for 2 weeks. The angiotensin II treatment increased blood pressure and heart weight/body weight ratio in wild-type mice but not in knockout mice. The generation of hydroxyl radicals in heart tissue homogenate was directly assessed with electron spin resonance spectroscopy using a spin trapping agent, alpha-phenyl-N-tert butylnitrone. Angiotensin II significantly increased hydroxyl radical production 2.2-fold (p < 0.01) in the hearts of wildtype mice but not in knockout mice. The present study provided direct evidence for increased production of hydroxyl radicals in angiotensin II-induced cardiac hypertrophy through angiotensin II type-1a receptor. These findings in this study may provide important insights into the development of hypertrophy and the transition of hypertrophy to heart failure.

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  • Methamphetamine-induced neurotoxicity in mouse brain is attenuated by ketoprofen, a non-steroidal anti-inflammatory drug 査読

    Masato Asanuma, Takeshi Tsuji, Ikuko Miyazaki, Ko Miyoshi, Norio Ogawa

    Neuroscience Letters   352 ( 1 )   13 - 16   2003年11月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.neulet.2003.08.015

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  • ドパミンおよびその誘導体のキノン体生成を介したアポトーシス誘導性.

    浅沼幹人, 宮崎育子, Haque ME, 東 洋一郎, 小川紀雄

    Prog Med   23 ( 10 )   2736 - 2741   2003年10月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • Overexpression of Cu-Zn superoxide dismutase protects neuroblastoma cells against dopamine cytotoxicity accompanied by increase in their glutathione level 査読

    M.Emdadul Haque, Masato Asanuma, Youichirou Higashi, Ikuko Miyazaki, Ken-ichi Tanaka, Norio Ogawa

    Neuroscience Research   47 ( 1 )   31 - 37   2003年9月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/s0168-0102(03)00166-4

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  • Apoptosis-inducing neurotoxicity of dopamine and its metabolites via reactive quinone generation in neuroblastoma cells 査読

    M Emdadul Haque, Masato Asanuma, Youichirou Higashi, Ikuko Miyazaki, Ken-ichi Tanaka, Norio Ogawa

    Biochimica et Biophysica Acta - General Subjects   1619 ( 1 )   39 - 52   2003年1月

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    担当区分:責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/s0304-4165(02)00440-3

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  • Dopamine- or L-DOPA-induced neurotoxicity: The role of dopamine quinone formation and tyrosinase in a model of Parkinson’s disease 査読

    Masato Asanuma, Ikuko Miyazaki, Norio Ogawa

    Neurotoxicity Research   5 ( 3 )   165 - 176   2003年1月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1007/bf03033137

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  • アルツハイマー病脳で減少しているgrowth inhibitory factor (GIF) の加齢にともなう変化.

    浅沼幹人, 宮崎育子, 東 洋一郎, 田中健一, 小川紀雄

    分子精神医学   3 ( 1 )   69 - 70   2003年

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • 非ステロイド性消炎鎮痛薬の神経保護作用の新展開. 査読

    浅沼幹人, 宮崎育子, 辻 武史, 小川紀雄

    日本神経精神薬理学会雑誌   23 ( 3 )   111 - 119   2003年

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • テトラサイクリン誘導体ミノサイクリンの種々の神経障害に対する保護作用. 招待

    浅沼幹人

    ファルマシア   38 ( 11 )   1105 - 1106   2002年11月

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    担当区分:筆頭著者, 責任著者   記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:公益社団法人日本薬学会  

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  • The p53-activated Gene, PAG608, Requires a Zinc Finger Domain for Nuclear Localization and Oxidative Stress-induced Apoptosis 査読

    Youichirou Higashi, Masato Asanuma, Ikuko Miyazaki, M. Emdadul Haque, Naoko Fujita, Ken-ichi Tanaka, Norio Ogawa

    Journal of Biological Chemistry   277 ( 44 )   42224 - 42232   2002年11月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1074/jbc.m203594200

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  • Age-related changes in expression of metallothionein-III in rat brain 査読

    Ikuko Miyazaki, Masato Asanuma, Youichirou Higashi, Chiharu Aoki Sogawa, Ken-ichi Tanaka, Norio Ogawa

    Neuroscience Research   43 ( 4 )   323 - 333   2002年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/s0168-0102(02)00057-3

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  • The dopamine agonist cabergoline provides neuroprotection by activation of the glutathione system and scavenging free radicals 査読

    Michiyo Yoshioka, Ken-ichi Tanaka, Ikuko Miyazaki, Naoko Fujita, Youichirou Higashi, Masato Asanuma, Norio Ogawa

    Neuroscience Research   43 ( 3 )   259 - 267   2002年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/s0168-0102(02)00040-8

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  • Aggravation of 6-hydroxydopamine-induced dopaminergic lesions in metallothionein-I and -II knock-out mouse brain 査読

    Masato Asanuma, Ikuko Miyazaki, Youichirou Higashi, Ken-ichi Tanaka, Md Emdadul Haque, Naoko Fujita, Norio Ogawa

    Neuroscience Letters   327 ( 1 )   61 - 65   2002年7月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/s0304-3940(02)00346-4

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  • Methamphetamine-induced increase in striatal p53 DNA-binding activity is attenuated in Cu,Zn-superoxide dismutase transgenic mice 査読

    Masato Asanuma, Ikuko Miyazaki, Youichirou Higashi, Jean Lud Cadet, Norio Ogawa

    Neuroscience Letters   325 ( 3 )   191 - 194   2002年6月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/s0304-3940(02)00291-4

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  • ニューロメラニン合成酵素チロシナーゼのドパミン神経障害への関与.

    浅沼幹人, 東 洋一郎, 宮崎育子, 小川紀雄

    Prog Med   22 ( 1 )   212 - 215   2002年1月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • Progressive cortical atrophy after forebrain ischemia in diabetic rats 査読

    Fumio Kondo, Masato Asanuma, Ikuko Miyazaki, Yoichi Kondo, Ken-ichi Tanaka, Hirohumi Makino, Norio Ogawa

    Neuroscience Research   39 ( 3 )   339 - 346   2001年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/s0168-0102(00)00233-9

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  • Neuroprotective effects of non-steroidal anti-inflammatory drugs by direct scavenging of nitric oxide radicals 査読

    Masato Asanuma, Sakiko Nishibayashi-Asanuma, Ikuko Miyazaki, Masahiro Kohno, Norio Ogawa

    Journal of Neurochemistry   76 ( 6 )   1895 - 1904   2001年3月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1046/j.1471-4159.2001.00205.x

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  • Delta opioid peptide [D-Ala2, D-Leu5]enkephalin causes a near complete blockade of the neuronal damage induced by a single high dose of methamphetamine: Examining the role of p53 査読

    Teruo Hayashi, Hiroshi Hirata, Masato Asanuma, Bruce Ladenheim, Li-I Tsao, Jean Lud Cadet, Tsung-Ping Su

    Synapse   39 ( 4 )   305 - 312   2001年3月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1002/1098-2396(20010315)39:4<305::aid-syn1013>3.0.co;2-e

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  • Localization, regulation, and function of metallothionein-III/growth inhibitory factor in the brain. 査読

    Chiharu Aoki Sogawa, Masato Asanuma, Norio Sogawa, Ikuko Miyazaki, Tohru Nakanishi, Hiroaki Furuta, Norio Ogawa

    Acta Medica Okayama   55 ( 1 )   1 - 9   2001年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Okayama University Medical School  

    <p>The metallothionein (MT) family is a class of low molecular, intracellular, and cysteine-rich proteins with a high affinity for metals. Although the first of these proteins was discovered nearly 40 years ago, their functional significance remains obscure. Four major isoforms (MT-I, MT-II, MT-III, and MT-IV) have been identified in mammals. MT-I and MT-II are ubiquitously expressed in various organs including the brain, while expression of MT-III and MT-IV is restricted in specific organs. MT-III was detected predominantly in the brain, and characterized as a central nervous system-specific isomer. The role of MTs in the central nervous system has become an intense focus of scientific research. An isomer of MTs, MT-III, of particular interest, was originally discovered as a growth inhibitory factor, and has been found to be markedly reduced in the brain of patients with Alzheimer's disease and several other neurodegenerative diseases. MT-III fulfills unique biological roles in homeostasis of the central nervous system and in the etiology of neuropathological disorders.</p>

    DOI: 10.18926/AMO/32031

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  • 酸化ストレスと神経細胞死. 招待

    小川紀雄, 浅沼幹人

    Clinical Neuroscience   19 ( 6 )   665 - 667   2001年

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  • フリーラジカルと脳障害. 招待

    浅沼幹人, 小川紀雄

    Clinical Neuroscience   19 ( 5 )   555 - 559   2001年

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • Molecular mechanism in activation of glutathione system by ropinirole, a selective dopamine D2 agonist. 査読

    Ken-ichi Tanaka, Ikuko Miyazaki, Naoko Fujita, Md Emdadul Haque, Masato Asanuma, Norio Ogawa

    Neurochemical Research   26 ( 1 )   31 - 36   2001年

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1023/a:1007672414239

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  • Immunophilin ligands prevent H2O2-induced apoptotic cell death by increasing glutathione levels in neuro 2A neuroblastoma cells. 査読

    Ken-ichi Tanaka, Naoko Fujita, Masato Asanuma, Norio Ogawa

    Acta Medica Okayama   54 ( 6 )   275 - 280   2000年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Okayama University Medical School  

    <p>We examined the effects of FK506 and its non-immunosuppressive derivative, GPI1046, on H2O2-induced reduction of cell viability and apoptotic cell death in Neuro 2A cells. Our results suggest that the protective properties of GPI1046 against H2O2-induced reduction of cell viability are equipotent with those of FK506 and may be mediated by increased intracellular concentrations of glutathione (GSH). In addition, both FK506 and GPI1046 prevented apoptotic cell death in Neuro 2A cells, although the antiapoptotic effect of FK506 was somewhat stronger than that of GPI1046. These findings suggest that non-immunosuppressive immunophilin ligands such as GPI1046 might be potentially useful in treatment of neurodegenerative diseases without serious side effects such as immune deficiency.</p>

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  • Expression of metallothionein-III mRNA and its regulation by levodopa in the basal ganglia of hemi-parkinsonian rats 査読

    Ikuko Miyazaki, Chiharu Aoki Sogawa, Masato Asanuma, Youichirou Higashi, Ken-ichi Tanaka, Tohru Nakanishi, Norio Ogawa

    Neuroscience Letters   293 ( 1 )   65 - 68   2000年10月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/s0304-3940(00)01488-9

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  • Inhibition of Tyrosinase Reduces Cell Viability in Catecholaminergic Neuronal Cells 査読

    Youichirou Higashi, Masato Asanuma, Ikuko Miyazaki, Norio Ogawa

    Journal of Neurochemistry   75 ( 4 )   1771 - 1774   2000年10月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1046/j.1471-4159.2000.0751771.x

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  • Direct interactions of methamphetamine with the nucleus 査読

    Masato Asanuma, Teruo Hayashi, Sonia V Ordonèz, Norio Ogawa, Jean Lud Cadet

    Molecular Brain Research   80 ( 2 )   237 - 243   2000年9月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/s0169-328x(00)00128-5

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  • Bromocriptine markedly suppress levodopa-induced abnormal increase of dopamine turnover in the parkinsonian striatum 査読

    Norio Ogawa, Ken-ichi Tanaka, Masato Asanuma

    Neurochemical Research   25 ( 6 )   755 - 758   2000年6月

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    担当区分:最終著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1023/a:1007530720544

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  • フリーラジカルと神経細胞死. 招待

    浅沼幹人, 小川紀雄

    Clinical Neuroscience   18 ( 4 )   415 - 417   2000年4月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • Antioxidants protect against dopamine-induced metallothionein-III (GIF) mRNA expression in mouse glial cell line (VR-2g) 査読

    Chiharu Aoki Sogawa, Ikuko Miyazaki, Norio Sogawa, Masato Asanuma, Norio Ogawa, Hiroaki Furuta

    Brain Research   853 ( 2 )   310 - 316   2000年1月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/s0006-8993(99)02284-2

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  • Protective effect of oren-gedoku-to against induction of neuronal death by transient cerebral ischemia in the C57BL/6 mouse 査読

    Yoichi Kondo, Fumio Kondo, Masato Asanuma, Ken-ichi Tanaka, Norio Ogawa

    Neurochemical Research   25 ( 2 )   205 - 209   2000年

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1023/a:1007515318434

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  • Bifemelane hydrochloride protects against cytotoxicity of hydrogen peroxide on cultured rat neuroblastoma cell line 査読

    Ikuko Miyazaki, Emi Iwata-Ichikawa, Masato Asanuma, Motoyuki Iida, Norio Ogawa

    Neurochemical Research   24 ( 7 )   857 - 860   1999年7月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1023/a:1020953913490

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  • Glial Cells Protect Neurons Against Oxidative Stress via Transcriptional Up-Regulation of the Glutathione Synthesis 査読

    Emi Iwata-Ichikawa, Yoichi Kondo, Ikuko Miyazaki, Masato Asanuma, Norio Ogawa

    Journal of Neurochemistry   72 ( 6 )   2334 - 2344   1999年6月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1046/j.1471-4159.1999.0722334.x

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  • Nitric oxide modulates muscarinic acetylcholine receptor binding in the cerebral cortex of gerbils 査読

    Marvin Gómez-Vargas, Masato Asanuma, Sakiko Nishibayashi-Asanuma, Emi Iwata, Norio Ogawa

    Neurochemical Research   24 ( 5 )   629 - 635   1999年5月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1023/a:1021044107323

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  • パーキンソン病と活性酸素・窒素種. 招待

    浅沼幹人, 小川紀雄

    神経研究の進歩   43 ( 2 )   264 - 274   1999年4月

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    担当区分:筆頭著者, 責任著者   記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:医学書院  

    DOI: 10.11477/mf.1431901046

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    その他リンク: http://search.jamas.or.jp/link/ui/1999175489

  • Early treatment with cyclosporin A ameliorates the reduction of muscarinic acetylcholine receptors in gerbil hippocampus after transient forebrain ischemia 査読

    Yoichi Kondo, Masato Asanuma, Emi Iwata, Fumio Kondo, Ikuko Miyazaki, Norio Ogawa

    Neurochemical Research   24 ( 1 )   9 - 13   1999年

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1023/a:1020915727119

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  • Neural transplantation normalizes dopaminegic dysfunction in an animal model of Parkinson's disease. 査読

    Norio Ogawa, Kiminao Mizukawa, Hitoo Nishino, Masato Asanuma, Mitsutoshi Yamamoto

    Journal of Brain Science   25 ( 3-4 )   133 - 138   1999年

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  • ホスホジエステラーゼ 招待

    浅沼幹人

    生体の科学   49 ( 5 )   499 - 501   1998年10月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

    DOI: 10.11477/mf.2425901650

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  • Chronic cerebral hypoperfusion disrupts discriminative behavior in acquired-learning rats 査読

    Ken-ichi Tanaka, Naoko Wada, Koji Hori, Masato Asanuma, Masahiko Nomura, Norio Ogawa

    Journal of Neuroscience Methods   84 ( 1-2 )   63 - 68   1998年10月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/s0165-0270(98)00092-2

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  • Melatonin attenuates methamphetamine-induced toxic effects on dopamine and serotonin terminals in mouse brain 査読

    Hiroshi Hirata, Masato Asanuma, Jean Lud Cadet

    Synapse   30 ( 2 )   150 - 155   1998年10月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1002/(sici)1098-2396(199810)30:2<150::aid-syn4>3.0.co;2-b

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  • Methamphetamine-induced increase in striatal NF-κB DNA-binding activity is attenuated in superoxide dismutase transgenic mice 査読

    Masato Asanuma, Jean Lud Cadet

    Molecular Brain Research   60 ( 2 )   305 - 309   1998年10月

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    担当区分:筆頭著者   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/s0169-328x(98)00188-0

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  • Parkinson病とNO. 招待

    小川紀雄, 浅沼幹人

    Clinical Neuroscience   16 ( 7 )   806 - 808   1998年7月

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    担当区分:最終著者   掲載種別:研究論文(学術雑誌)  

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  • Superoxide radicals are mediators of the effects of methamphetamine on Zif268 (Egr-1, NGFI-A) in the brain: evidence from using CuZn superoxide dismutase transgenic mice 査読

    Hiroshi Hirata, Masato Asanuma, Jean Lud Cadet

    Molecular Brain Research   58 ( 1-2 )   209 - 216   1998年7月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/s0169-328x(98)00055-2

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  • Protective effects of nicergoline against hydrogen peroxide toxicity in rat neuronal cell line 査読

    Emi Iwata, Ikuko Miyazaki, Masato Asanuma, Azusa Iida, Norio Ogawa

    Neuroscience Letters   251 ( 1 )   49 - 52   1998年7月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/s0304-3940(98)00489-3

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  • Pergolide scavenges both hydroxyl and nitric oxide free radicals in vitro and inhibits lipid peroxidation in different regions of the rat brain 査読

    Marvin Gómez-Vargas, Sakiko Nishibayashi-Asanuma, Masato Asanuma, Yoichi Kondo, Emi Iwata, Norio Ogawa

    Brain Research   790 ( 1-2 )   202 - 208   1998年4月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/s0006-8993(97)01521-7

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  • Attenuation of 6-hydroxydopamine-induced dopaminergic nigrostriatal lesions in superoxide dismutase transgenic mice 査読

    Masato Asanuma, Hiroshi Hirata, Jean L Cadet

    Neuroscience   85 ( 3 )   907 - 917   1998年4月

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    担当区分:筆頭著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/s0306-4522(97)00665-9

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  • Manda, a fermented natural food, suppresses lipid peroxidation in the senescent rat brain 査読

    Motoko Kawai, Shingoro Matsuura, Masato Asanuma, Norio Ogawa

    Neurochemical Research   23 ( 4 )   455 - 461   1998年4月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1023/a:1022475830587

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  • Effects of repeated cyclosporin A administration on iminodipropionitrile-induced dyskinesia and TRE-/CRE-binding activities in rat brain 査読

    Kyoko Iida, Emi Iwata, Masato Asanuma, Sakiko N Asanuma, Marvin Gómez-Vargas, Ikuko Miyazaki, Tohru Nakanishi, Norio Ogawa

    Neuroscience Research   30 ( 2 )   185 - 193   1998年2月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/s0168-0102(97)00128-4

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  • Effects of Lecithinized SOD on Sequential Change in SOD Activity after Cerebral Contusion in Rats 査読

    Masatoshi Yunoki, Masamitsu Kawauchi, Naoya Ukita, Yasuhiro Noguchi, Shinsaku Nishio, Yasuhiro Ono, Shoji Asari, Takashi Ohmoto, Masato Asanuma, Norio Ogawa

    Acta Neurochir Suppl   71   142 - 145   1998年

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    掲載種別:論文集(書籍)内論文   出版者・発行元:Springer Vienna  

    DOI: 10.1007/978-3-7091-6475-4_42

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  • Dantrolene sodium reverses the increase in cAMP response element and TPA responsive element DNA-binding activity in the rabbit brain following haloperidol administration and heat stress 査読

    Hisashi Tanii, Norio Taniguchi, Ichiro Tsujio, Masato Asanuma, Emi Iwata, Takashi Kudo, Norio Ogawa, Masatoshi Takeda

    Psychiatry and Clinical Neurosciences   51 ( 6 )   415 - 420   1997年12月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1111/j.1440-1819.1997.tb02610.x

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  • Effects of Lecithinized Superoxide Dismutase on Traumatic Brain Injury in Rats 査読

    Masatoshi Yunoki, Masamitsu Kawauchi, Naoya Ukita, Yasuhiro Noguchi, Shinsaku Nishio, Yasuhiro Ono, Shoji Asari, Takashi Ohmoto, Masato Asanuma, Norio Ogawa

    Journal of Neurotrauma   14 ( 10 )   739 - 746   1997年10月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Mary Ann Liebert Inc  

    DOI: 10.1089/neu.1997.14.739

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  • Different effects of oxidative stress on activation of transcription factors in primary cultured rat neuronal and glial cells 査読

    Emi Iwata, Masato Asanuma, Sakiko Nishibayashi, Yoichi Kondo, Norio Ogawa

    Molecular Brain Research   50 ( 1-2 )   213 - 220   1997年10月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/s0169-328x(97)00190-3

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  • Late-onset lipid peroxidation and neuronal cell death following transient forebrain ischemia in rat brain 査読

    Yoichi Kondo, Masato Asanuma, Sakiko Nishibayashi, Emi Iwata, Norio Ogawa

    Brain Research   772 ( 1-2 )   37 - 44   1997年10月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/s0006-8993(97)00836-6

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  • Genetic association between susceptibility to Parkinson's disease and α1-antichymotrypsin polymorphism 査読

    Mitsutoshi Yamamoto, Ikuko Kondo, Norio Ogawa, Masato Asanuma, Yoshiaki Yamashita, Yoshikuni Mizuno

    Brain Research   759 ( 1 )   153 - 155   1997年6月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/s0006-8993(97)00330-2

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  • Thyrotropin releasing hormone prevents abnormalities of cortical acetylcholine and monoamines in mice following head injury 査読

    Ken-ichi Tanakaa, Norio Ogawa, Masato Asanuma, Yoichi Kondo

    Regulatory Peptides   70 ( 2-3 )   173 - 178   1997年6月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/s0167-0115(97)01013-6

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  • Direct evidence of high DNA binding activity of transcription factor AP-1 in rheumatoid arthritis synovium 査読

    Hiroshi Asahara, Koushi Fujisawa, Tetsuji Kobata, Tomoko Hasunuma, Toshiro Maeda, Masato Asanuma, Norio Ogawa, Hajime Inoue, Takayuki Sumida, Kusuki Nishioka

    Arthritis & Rheumatism   40 ( 5 )   912 - 918   1997年5月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1002/art.1780400520

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  • Ketoprofen, a non-steroidal anti-inflammatory drug prevents the late-onset reduction of muscarinic receptors in gerbil hippocampus after transient forebrain ischemia 査読

    Masato Asanuma, Sakiko N Asanuma, Marvin Gómez-Vargas, Mitsutoshi Yamamoto, Norio Ogawa

    Neuroscience Letters   225 ( 2 )   109 - 112   1997年4月

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    担当区分:筆頭著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/s0304-3940(97)00204-8

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  • 脳内転写制御因子CREB, AP-1のDNA結合活性に及ぼすドパミンレセプター作用薬の影響.

    浅沼幹人

    Prog. Med.   17 ( 2 )   423 - 430   1997年2月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • 神経細胞死と活性酸素・フリーラジカル.. 招待

    小川紀雄, 近藤洋一, 岩田恵美, 浅沼幹人, 飯田基之

    フリーラジカルの臨床   11   101 - 106   1997年

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  • Protective effects of FK506 on the late-onset reduction of muscarinic acetylcholine receptors in gerbil hippocampus after transient forebrain ischemia 査読

    Sakiko Nishibayashi, Yoichi Kondo, Masato Asanuma, Emi Iwata, Marvin Gomez-Vargas, Norio Ogawa

    Journal of Brain Science   23 ( 1 )   33 - 40   1997年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN BRAIN SCI SOC  

    Late-onset reduction of muscarinic acetylcholine receptors (LORMAR) in the ischemic gerbil hippocampus begins as late as 7 days after a 5-min transient forebrain ischemia and reperfusion. We previously reported that LORMAR is prevented by postadministration of cyclosporin A. In the present study, we aim to elucidate whether the LORMAR can also be prevented by post-ischemic administration of the immunosuppressant FK506 (tacrolimus). We investigated changes in muscarinic acetylcholine receptor binding capacity and histological examination in the transient forebrain ischemic gerbil hippocampus and the effect of this agent on these changes. In the ischemic vehicle-treated group, muscarinic acetylcholine receptors significantly decreased in the hippocampus as the LORMAR with subsequent disruption of the pyramidal cells in the CA1 area. On the other hand, LORMAR is prevented by daily subcutaneous administration of low dose of FK506 (0.5 mg/kg/day) for 10 days after the ischemic insult, although delayed neuronal cell death was not prevented. Thus, we showed that the LORMAR is attenuated by post-administration of FK506.

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  • Chronic administration of Oren-gedoku-to (TJ15) inhibits ischemic-induced changes in brain indoleamine metabolism and muscarinic receptor binding in the Mongolian gerbil 査読

    Hideaki Kabuto, Masato Asanuma, Sakiko Nishibayashi, Motoyuki Iida, Norio Ogawa

    Neurochemical Research   22 ( 1 )   33 - 36   1997年

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1023/a:1027369119224

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  • Aniracetam ameriorates impaired pre- and post-synaptic cholinergic indices in gerbil hippocampus induced by transient forebrain ischemia 査読

    Yoichi Kondo, Masato Asanuma, Hideaki Kabuto, Emi Iwata, Fumio Kondo, Ikuko Miyazaki, Norio Ogawa

    Journal of Brain Science   23 ( 4 )   250 - 260   1997年

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  • Effects of Lecithinized SOD on Contusion Injury in Rats 査読

    Masatoshi Yunoki, Yasuhiro Noguchi, Shinsaku Nishio, Yasuhiro Ono, Masamitsu Kawauchi, Shoji Asai, Takashi Ohmoto, Masato Asanuma, Norio Ogawa

    Acta Neurochir Suppl   70   182 - 184   1997年

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    掲載種別:論文集(書籍)内論文   出版者・発行元:Springer Vienna  

    DOI: 10.1007/978-3-7091-6837-0_56

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  • Scavenging Effects of Dopamine Agonists on Nitric Oxide Radicals 査読

    Sakiko Nishibayashi, Masato Asanuma, Masahiro Kohno, Marvin Gómez-Vargas, Norio Ogawa

    Journal of Neurochemistry   67 ( 5 )   2208 - 2211   1996年11月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1046/j.1471-4159.1996.67052208.x

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  • Alterations of cAMP response element-binding acitvity in the aged rat brain in response to adminostration of rolipram, a cAMP-specific phosphodiesterase inhibitor. 査読

    Masato Asanuma, Sakiko Nishibayashi, Emi Iwata, Yoichi Kondo, Tohru Nakanishi, Marvin Gómez Vargas, Norio Ogawa

    Molecular Brain Research   41 ( 1-2 )   210 - 215   1996年9月

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    担当区分:筆頭著者   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/0169-328x(96)00098-8

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  • Relationship between cholinergic dysfunction and discrimination learning disabilities in Wistar rats following chronic cerebral hypoperfusion 査読

    Ken-ichi Tanaka, Norio Ogawa, Masato Asanuma, Yoichi Kondo, Masahiko Nomura

    Brain Research   729 ( 1 )   55 - 65   1996年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    The effects of chronic hypoperfusion of cerebral blood flow (CBF) on central cholinergic indices and intellectual functions were investigated in rats. Male Wistar rats, aged 9 weeks, were anesthetized with pentobarbital, and the bilateral common carotid arteries were permanently ligated. Cortical CBF in the hypoperfused rats was markedly decreased at 6 weeks after the operation. In the hypoperfused group, cholinergic indices were changed to consist two phases after the operation, before (acute) and after (chronic) 6 weeks after the operation. At 6 weeks, choline acetyltransferase activity was restored to the sham-operated level compared with the changes in the frontal cortex and thalamus + midbrain at 3 weeks. On the other hand, the maximum number of muscarinic acetylcholine receptors was reduced in the frontal cortex, hippocampus and striatum at 6 weeks and thereafter remained at this low level. In discrimination learning task, the percentage of correct responses in the hypoperfused rats was generally reduced in contrast with that of the sham-operated rats, although the number of total responses were not changed. As a consequence, cholinergic dysfunctions correlate with discrimination learning disabilities in the hypoperfused rats. These findings suggest that the hypoperfused rat may be useful for the cerebrovascular type dementia model to clarify pathophysiology.

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  • Effects of Bromocriptine on Dopamine Turnover with or without Levodopa 査読

    Norio Ogawa, Masato Asanuma, Ken-ichi Tanaka, Koji Matsuura, Kyoko Iida, Mitsutoshi Yamamoto

    Journal of International Medical Research   24 ( 3 )   271 - 277   1996年5月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:SAGE Publications  

    Bromocriptine, a dopamine agonist, alleviates symptoms of Parkinson's disease, even when administered alone, and is used for its treatment. Better therapeutic effects are, however, achieved when bromocriptine is used in combination with levodopa. In this study, we examined the biochemical changes caused by bromocriptine administration with and without levodopa, and evaluated the effects of the treatments on dopamine turnover in the mouse striatum. Results show that dopamine turnover is suppressed by the administration of bromocriptine alone with a slight decrease in the amount of dopamine, and dopamine turnover is very strongly promoted by the administration of levodopa. When the two drugs are administered together, bromocriptine enhances the levodopa-induced increase in dopamine turnover in the striatum. These findings indicate that bromocriptine therapy in combination with levodopa enhances the dopaminergic function and suggest that the combination therapy of bromocriptine and levodopa shows good efficacy. The results of this study may, thus, provide a theoretical basis for the combination therapy of bromocriptine and levodopa.

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  • L-DOPA合剤の変更による老齢パーキンソン病患者の問題症状の改善 招待

    浅沼幹人

    老化と疾患   9 ( 4 )   521 - 525   1996年4月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • Expression of mRNA encoding neurotrophic factors and its regulation in a hybrid neuronal cell line 査読

    Tohru Nakanishi, Kazuhiro Ishii, Nobuyuki Fukushima, Masato Asanuma, Emi Iwata, Norio Ogawa

    Biochemistry and Molecular Biology International   38 ( 4 )   763 - 772   1996年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACADEMIC PRESS AUST  

    In a cultured hybrid neuronal cell line (BIM) which was produced between human neuroblastoma cells (IMR32) and thymidine auxotrophs (B3T) of rat nerve-like cells (B103), the mRNAs encoding ciliary neurotrophic factor (CNTF) and neurotrophins were detected by the polymerase chain reaction method. The conditioned medium of BIM cells enhanced choline acetyltransferase (ChAT) activity in septal neurons and survival of-ciliary ganglion neurons. The mRNA expression of CNTF and neurotrophins in BIM cells was differently regulated by the stimulation with cAMP, FGF and retinoic acid. These data suggest multiple regulation and collaboration of neurotrophic factors.

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  • Preventive effects of bifemelane hydrochloride on decreased levels of muscarinic acetylcholine receptor and its mRNA in a rat model of chronic cerebral hypoperfusion 査読

    Yoichi Kondo, Norio Ogawa, Masato Asanuma, Koji Matsuura, Sakiko Nishibayashi, Emi Iwata

    Neuroscience Research   24 ( 4 )   409 - 414   1996年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/0168-0102(95)01017-3

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  • Long-term time course of regional changes in cholinergic indices following transient ischemia in the spontaneously hypertensive rat brain 査読

    Norio Ogawa, Masato Asanuma, Ken-ichi Tanaka, Hiroshi Hirata, Yoichi Kondo, Masaki Goto, Masamitsu Kawauchi, Toshio Ogura

    Brain Research   712 ( 1 )   60 - 68   1996年3月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/0006-8993(95)01446-2

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  • Age-related changes in composition of transcription factor, AP-1 complex in the rat brain 査読

    Masato Asanuma, Yoichi Kondo, Sakiko Nishibayashi, Emi Iwata, Tohru Nakanishi, Norio Ogawa

    Neuroscience Letters   201 ( 2 )   127 - 130   1995年12月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/0304-3940(95)12152-8

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  • 脳の老化と生化学 招待

    浅沼幹人, 小川紀雄

    臨床と研究   72 ( 11 )   2654 - 2658   1995年11月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • High DNA-binding activity of transcription factor NF-κB in synovial membranes of patients with rheumatoid arthritis. 査読

    Hiroshi Asahara, Masato Asanuma, Norio Ogawa, Sakiko Nishibayashi, Hajime Inoue

    Biochemistry and Molecular Biology International   37 ( 5 )   827 - 832   1995年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACADEMIC PRESS AUST  

    Our objective was to clarify the DNA-binding activity of transcription factor NF-kappa B as related to cytokine induction in the synovium of patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Synovial membranes were obtained during arthroplasty of the knee from 7 patients with RA and 4 patients with OA. Nuclear extracts obtained from the synovial membranes were examined by electrophoretic mobility shift assay to determine the DNA-binding activity of NF-kappa B. Markedly high DNA-binding activity of NF-kappa B was detected in the synovial membranes of RA patients, while virtually no activity was observed in those of OA patients. These results suggest that the high induction of NF-kappa B in the nuclear extracts may be relatively specific to synovial membranes in RA. NF-kappa B may regulate the production of cytokines at the site of synovial inflammation.

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  • Effects of single cyclosporin A pretreatment on pentylenetetrazol-induced convulsion and on TRE-binding activity in the rat brain 査読

    Masato Asanuma, Sakiko Nishibayashi, Yoichi Kondo, Emi Iwata, Masaaki Tsuda, Norio Ogawa

    Molecular Brain Research   33 ( 1 )   29 - 36   1995年10月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/0169-328x(95)00102-x

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  • M1 Receptors in Blood Pressure–Controlled Ischemic Spontaneously Hypertensive Rats 査読

    Hiroshi Hirata, Masato Asanuma, Ken-ichi Tanaka, Yoichi Kondo, Norio Ogawa

    Stroke   26 ( 7 )   1268 - 1272   1995年7月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Ovid Technologies (Wolters Kluwer Health)  

    <italic>Background and Purpose</italic>
    Hypertension is a primary aggravating factor in cerebral infarction. An acute rise in blood pressure (BP) at the time of a stroke may be harmful to the brain in a hypertensive subject because both cerebral vascular structure and function are altered by hypertension. Muscarinic M
    1
    receptors are concerned with memory and learning. We aimed to evaluate the effect of controlling BP in hypertensive subjects at the time of stroke with a biochemical index of brain damage.




    <italic>Methods</italic>
    We gave a single dose of either the antihypertensive α-blocker phentolamine (2 mg/kg IP) or the calcium antagonist nicardipine (2 mg/kg IP) at the start of bilateral carotid artery occlusion to spontaneously hypertensive rats undergoing 3 hours of transient ischemia; we measured the time course of mean BP (MBP) and changes in the M
    1
    receptor and its mRNA in three brain regions 2 weeks after the transient ischemia.




    <italic>Results</italic>
    Administration of phentolamine or nicardipine not only significantly suppressed the ischemia-induced rise of MBP, it actually decreased MBP during ischemia. In an ischemic control group, M
    1
    receptor binding decreased in the frontal cortex and M
    1
    receptor mRNA increased in the hippocampus 2 weeks after the ischemia. In contrast, both phentolamine- and nicardipine-treated ischemic rats showed no changes in either index compared with sham-operated controls.




    <italic>Conclusions</italic>
    Controlling BP during an ischemic insult attenuates ischemia-induced damage of M
    1
    receptors in the brain of spontaneously hypertensive rats. These results suggest that a rapid intensive increase of BP at the time of a stroke may exacerbate brain damage in hypertensive individuals.

    DOI: 10.1161/01.str.26.7.1268

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  • 神経変性過程における免疫制御薬シクロスポリンAの効果 招待

    小川紀雄, 浅沼幹人

    Dementia   9 ( 2 )   153 - 161   1995年4月

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    担当区分:最終著者   掲載種別:研究論文(学術雑誌)  

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  • Cholecystokinin alterations and effects of levodopa administration in the MPTP-treated mouse brain 査読

    Emi Iwata, Masato Asanuma, Yoichi Kondo, Sakiko Nishibayashi, Koji Matsuura, Norio Ogawa

    Research Communications in Molecular Pathology and Pharmacology   88 ( 1 )   31 - 38   1995年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:P J D PUBLICATIONS LTD  

    To clarify the effects of levodopa administration on MPTP-induced alterations in neuropeptides, we examined the effects of repeated levodopa injections (200 mg/kg i.p.) for 2 weeks starting 4 weeks after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment (30 mg/kg i.p. twice/day for 5 days) on cholecystokinin-octapeptide (CCK-8), substance P (SP) and thyrotropin-releasing hormone (TRH) concentrations at 6 weeks after the MPTP treatment. In the striatum, CCK-8 significantly but slightly decreased in the MPTP-treated mice, coinciding with the MPTP-induced marked reduction of dopamine (DA). This considerable reduction of striatal CCK-8 may result from the selectivity of MPTP since the mesolimbic DA neurons coexisting with CCK-8 are intact with the MPTP treatment. Furthermore, this MPTP-induced decrease in CCK-8 persisted with repeated levodopa administration; therefore, the ineffectiveness of the levodopa treatment may have been be due to the degeneration of the nigrostriatal DA neurons. SP and TRH contents showed little or no change with levodopa treatment in the MPTP-treated mouse brain. The CCK-8 level decreased in the thalamus+midbrain, hippocampus and hindbrain of the MPTP + levodopa-treated group, although there were no changes in the MPTP-treated controls. These results suggest that DAergic neurons, except those in the nigrostriatum, strongly interact with the CCK neurons in these brain regions.

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  • Protective effects of pergolide on dopamine levels in the 6-hydroxydopamine-lesioned mouse brain 査読

    Masato Asanuma, Norio Ogawa, Sakiko Nishibayashi, Motoko Kawai, Yoichi Kondo, Emi Iwata

    Archives Internationales de Pharmacodynamie et de Therapie   329 ( 2 )   221 - 230   1995年3月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ARCH INT PHARMACODYNAMIE  

    Pergolide, along with bromocriptine and lisuride, is one of the most active dopamine receptor agonists. To determine whether or not pergolide protects against dopaminergic neuronal damage, via its activity on monoamine metabolism, we studied the effects of pergolide pretreatment on changes in monoamines and their metabolites in the mouse striatum after intracerebroventricular injection of 6-hydroxydopamine with pretreatment of desipramine. After intracerebroventricular administration of 6-hydroxydopamine (40 mu g) in mice, the levels of dopamine and its metabolites (DOPAC, HVA) in the striatum rapidly decreased to 49%, 29% and 68%, respectively, of the naive controls at week 1 but then gradually recovered to control levels at weeks 2 and 4. Repeated pretreatment with pergolide (0.5 mg/kg, i.p.) for 7 days before administration of 6-hydroxydopamine, almost completely protected against reduction in striatal dopamine and its metabolites 1 week after injection of 6-hydroxydopamine. Therefore, pergolide could normalize the decreased dopamine synthesis or storage, and has a neuroprotective effect against dopaminergic dysfunction induced by the neurotoxin, 6-hydroxydopamine. Although we found that pergolide did not show radical scavenging activity in an in vitro system that generated hydroxyl radicals, it has been reported in vivo that pergolide treatment may induce Cu/Zn superoxide dismutase in the rat striatum. Considering these findings, pergolide may well be protective to dopaminergic neurons, largely because of its effects on presynaptic autoreceptors and on its induction of Cu/Zn superoxide dismutase. Further research on the neuroprotective effects of pergolide in Parkinson disease models, by injection of 6-hydroxydopamine, is needed to clarify its mechanism of action on dopaminergic indices.

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  • Cyclosporin A prevents ischemia-induced reduction of muscarinic acetylcholine receptors with suppression of microglial activation in gerbil hippocampus 査読

    Yoichi Kondo, Norio Ogawa, Masato Asanuma, Sakiko Nishibayashi, Emi Iwata, Akitane Mori

    Neuroscience Research   22 ( 1 )   123 - 127   1995年3月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/0168-0102(95)00878-w

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  • Regional Differences in Late-Onset Iron Deposition, Ferritin, Transferrin, Astrocyte Proliferation, and Microglial Activation after Transient Forebrain Ischemia in Rat Brain 査読

    Yoichi Kondo, Norio Ogawa, Masato Asanuma, Zensuke Ota, Akitane Mori

    Journal of Cerebral Blood Flow & Metabolism   15 ( 2 )   216 - 226   1995年3月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:SAGE Publications  

    With use of iron histochemistry and immuno-histochemistry, regional changes in the appearance of iron, ferritin, transferrin, glial fibrillary acidic protein–positive astrocytes, and activated microglia were examined from 1 to 24 weeks after transient forebrain ischemia (four-vessel occlusion model) in rat brain. Expression of the C3bi receptor and the major histocompatibility complex class II antigen was used to identify microglia. Neuronal death was confirmed by hematoxylin–eosin staining only in pyramidal cells of the hippocampal CA, region, which is known as the area most vulnerable to ischemia. Perls' reaction with 3,3′-diaminobenzidine intensification revealed iron deposits in the CA, region after week 4, which gradually increased and formed clusters by week 24. Iron also deposited in layers III-V of the parietal cortex after week 8 and gradually built up as granular deposits in the cytoplasm of pyramidal cells in frontocortical layer V. An increasing astroglial reaction and the appearance of ferritin-immunopositive microglia paralleled the iron accumulation in the hippocampal CA, region, indicating that iron deposition was probably produced in the process of gliosis. Neither neuronal death nor atrophy was found in the cerebral cortex. Nevertheless, an astroglial and ferritin-immunopositive microglial reaction became evident at week 8 in the parietal cortex. On the other hand, the granular iron deposition in the pyramidal neurons of frontocortical layer V was not accompanied by any glial reaction in the chronic stage of ischemia. Three different types of iron deposition in the chronic phase after transient forebrain ischemia were shown in this study. In view of the neuronal damage caused by iron-catalyzed free radical formation, the late-onset iron deposition may be relevant to the pathogenesis of the chronic brain dysfunction seen at a late stage after cerebral ischemia.

    DOI: 10.1038/jcbfm.1995.27

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  • Angiotensin II Induces in vivo c-fosExpression from Rat Renal Cortex and Medulla 査読

    Teruaki Omiya, Takayoshi Yamauchi, Toshio Ogura, Masato Asanuma, Zensuke Ota

    Renal Physiology and Biochemistry   18 ( 2 )   81 - 88   1995年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:S. Karger AG  

    DOI: 10.1159/000173903

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  • Neuropeptide levels in discrete brain regions in the iminodipropionitrile-induced persistent dyskinesia rat model 査読

    Yoshiro Kawada, Norio Ogawa, Masato Asanuma, Akitane Mori

    Regulatory Peptides   55 ( 1 )   103 - 110   1995年1月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/0167-0115(94)00105-7

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  • Effects of repeated injection of cyclosporin A on pentylenetetrazole-induced convulsion and cyclophilin mRNA levels in rat brain. 査読

    Masato Asanuma, Norio Ogawa, Sakiko Nishibayashi, Yoichi Kondo, Akitane Mori

    Neurochemical Research   20 ( 1 )   101 - 105   1995年1月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/bf00995159

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  • 老齢ラット脳内における転写制御因子AP-1のFos-Jun/Jun dimer比の変化 査読

    浅沼幹人, 近藤洋一, 西林佐紀子, 岩田恵美, 松浦弘治, 小川紀雄, 森 昭胤

    Neurosciences   21   125 - 128   1995年

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • Chronic effects of transient forebrain ischemia on monoamines in the spontaneously hypertensive rat brain 査読

    Sakiko Nishibayashi, Masato Asanuma, Yoichi Kondo, Emi Iwata, Koji Matsuura, Toshio Ogura, Norio Ogawa

    Biogenic Amines   11 ( 2 )   187 - 194   1995年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:VSP BV  

    Using the 3-hr common carotid occlusion model in spontaneously hypertensive rats (SHRs), we investigated the changes in monoamines and their metabolites up to the chronic phase, 6 mouths after the transient forebrain ischemia, in various brain regions. In the striatum, the levels of dopamine (DA) at the 3rd week and serotonin (5-HT) at the 2nd week were 1.6-fold and 2.4-fold higher than the levels in the respective sham-operated controls coinciding with increases in their metabolites, homovanillic acid and 5-hydroxyindoleacetic acid. However, these marked increases in both transmitters were transient aid their levels recovered to the sham-operated levels. This transient increase in DA release in the striatum may be caused by ischemia-induced disruption of nerve endings, and may aggravate tissue damage in the striatum at the chronic phase after ischemia. Transient or lasting changes in noradrenaline, DA, 5-HT and their metabolites were also observed in other brain regions, the thalamus+midbrain and the hippocampus of SHRs after transient ischemia. These ischemia-induced alterations in monoamines at the chronic phase may be partly involved in the late-onset sequelae seen in the cerebrovascular disorders.

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  • 中枢神経における転写制御因子結合活性に対する酸化的ストレスの影響 査読

    岩田恵美, 浅沼幹人, 西林佐紀子, 近藤洋一, 松浦弘治, 小川紀雄, 森 昭胤

    Neurosciences   21   77 - 80   1995年

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    掲載種別:研究論文(学術雑誌)  

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  • ラット脳血流慢性低潅流時におけるアセチルコリン系の変化 査読

    西林佐紀子, 浅沼幹人, 近藤洋一, 岩田恵美, 松浦弘治, 飯田享子, 小川紀雄, 森 昭胤

    Neurosciences   21   109 - 112   1995年

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    掲載種別:研究論文(学術雑誌)  

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  • Regional changes in α-tubulin and β-actin mRNA accumlations after transient ischemia in spontaneously hypertensive rat brains 査読

    Yoichi Kondo, Norio Ogawa, Masato Asanuma, Hiroshi Hirata, Sakiko Nishibayashi, Akitane Mori

    Research Communications in Molecular Pathology and Pharmacology   86 ( 2 )   139 - 153   1994年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:P J D PUBLICATIONS LTD  

    Regional changes in the mRNA accumulations for cytoskeletal proteins alpha-tubulin and beta-actin were examined by in situ hybridization and Northern blot analysis in spontaneously hypertensive rat brains at chronic stages after 3 hours of transient ischemia. alpha-Tubulin mRNA accumulations showed no significant change at 2 weeks after transient ischemia except for a significant decrease in the frontal cortex (9.7%, p &lt; 0.01) coinciding with ischemia induced histological changes. beta-Actin mRNA level was significantly increased in the parietal cortex (8.5%), septum (10.0%), amygdala (11.0%), CA4 area (5.8%) and the dentate gyrus (7.5%) of the hippocampus at 2 weeks after recirculation compared with a sham-operated control group (p&lt;0.01). The ischemic areas of hippocampal and frontocortical lesions receive afferent neurons from those regions where beta-actin mRNA was increased, suggesting that ischemia-induced increases in beta-actin mRNA may reflect actin synthesis in these neurons to compensate for lost synaptic connections. Two cytoskeletal mRNA concentrations reacted differently to cerebral ischemia, and did not parallel histological signs of ischemia either temporally or spatially.

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  • Chronic administration of acetylcholinesterase inhibitor in the senescent Rat brain 査読

    Ken-ichi Tanaka, Norio Ogawa, Masato Asanuma, Yoichi Kondo, Akitane Mori

    Neurobiology of Aging   15 ( 6 )   721 - 725   1994年11月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/0197-4580(94)90054-x

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  • Tubulin and actin mRNAs in the young-adult and the aged rat brain: effects of repeated administration with bifemelane hydrochloride 査読

    Sakiko Nishibayashi, Norio Ogawa, Masato Asanuma, Yoichi Kondo, Akitane Mori

    Archives of Gerontology and Geriatrics   19 ( 3 )   265 - 272   1994年11月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/0167-4943(94)00572-9

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  • Bromocriptine protects mice against 6-hydroxydopamine and scavenges hydroxyl free radicals in vitro 査読

    Norio Ogawa, Ken-ichi Tanaka, Masato Asanuma, Motoko Kawai, Toshiki Masumizu, Masahiro Kohno, Akitane Mori

    Brain Research   657 ( 1-2 )   207 - 213   1994年9月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/0006-8993(94)90969-5

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  • Reduced choline acetyltransferase activity and muscar M1 receptor levels in aged Fisher 344 rat brains did not parallel their respective mRNA levels. 査読

    Norio Ogawa, Masato Asanuma, Yoichi Kondo, Sakiko Nishibayashi, Akitane Mori

    Brain Research   658 ( 1-2 )   87 - 92   1994年9月

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  • Effects of Repeated Immunosuppressant Treatment on Rat Pentylenetetrazol-Induced Convulsion 査読

    Masato Asanuma, Yoichi Kondo, Norio Ogawa, Akitane Mori

    Japanese Journal of Psychiatry and Neurology   48 ( 2 )   281 - 284   1994年6月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1111/j.1440-1819.1994.tb03068.x

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  • Amantadine(Symmetrel)の使い方と問題点 招待

    浅沼幹人, 小川紀雄

    内科   73 ( 5 )   868 - 870   1994年5月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • Changes in lipid peroxidation, Cu/Zn-superoxide dismutase and its mRNA following an intracerebroventricular injection of 6-hydroxydopamine 査読

    Norio Ogawa, Masato Asanuma, Yoichi Kondo, Hiroshi Hirata, Sakiko Nishibayashi, Akitane Mori

    Brain Research   646 ( 2 )   337 - 340   1994年5月

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  • Iminodipropionitrile投与によって発症させたジスキネジアモデルラットの脳内神経ペプチドの変化 査読

    河田義郎, 小川紀雄, 浅沼幹人, 森 昭胤

    Neurosciences   20   41 - 44   1994年4月

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    掲載種別:研究論文(学術雑誌)  

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  • Differential effects of chronic l-DOPA treatment on lipid peroxidation in the mouse brain with or without pretreatment with 6-hydroxydopamine 査読

    Norio Ogawa, Masato Asanuma, Yoichi Kondo, Yoshiro Kawada, Mitsutoshi Yamamoto, Akitane Mori

    Neuroscience Letters   171 ( 1-2 )   55 - 58   1994年4月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/0304-3940(94)90603-3

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  • 虚血と神経毒による晩発性脳障害 招待

    小川紀雄, 浅沼幹人, 水川公直

    老年期痴呆研究会誌   6   16 - 19   1994年2月

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    掲載種別:研究論文(学術雑誌)  

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  • Acetylcholinesterase inhibitor ENA-713 protects against ischemia-induced decrease in pre- and postsynaptic cholinergic indices in the gerbil brain following transient ischemia 査読

    Ken-ichi Tanaka, Norio Ogawa, Kiminao Mizukawa, Masato Asanuma, Yoichi Kondo, Sakiko Nishibayashi, Akitane Mori

    Neurochemical Research   19 ( 2 )   117 - 122   1994年2月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1007/bf00966804

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  • Pitfalls in Assessment of c-fos mRNA Expression in the Brain: Effects of Animal Handling 査読

    Masato Asanuma, Norio Ogawa

    Reviews in the Neurosciences   5 ( 2 )   1994年1月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Walter de Gruyter GmbH  

    DOI: 10.1515/revneuro.1994.5.2.171

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  • Effect of vagatomy on hyperactivity and increased dopamine turnover induced by intraperitoneal administration of thyrotropin-releasing hormone 査読

    Norio Ogawa, Masato Asanuma, Yoichi Kondo, Hiroshi Hirata, Naoharu Nakayama, Akitane Mori

    Brain Research   633 ( 1-2 )   167 - 170   1994年1月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/0006-8993(94)91536-9

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  • 脳障害過程での免疫系の関与-免疫抑制薬cyclosporine Aを用いた実験的研究- 査読

    小川紀雄, 浅沼幹人, 近藤洋一

    日本神経精神薬理学会雑誌   14   377 - 381   1994年

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    掲載種別:研究論文(学術雑誌)  

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  • Alterations in the binding of the phosphodiesterase inhibitor, rolipram, after transient ischemia in the gerbil brain 査読

    Masato Asanuma, Norio Ogawa, Hiroshi Hirata, Yoichi Kondo, Sakiko Nishibayashi, Mitsutoshi Yamamoto, Akitane Mori

    Research Communications in Molecular Pathology and Pharmacology   82 ( 3 )   279 - 285   1993年12月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:P J D PUBLICATIONS LTD  

    To determine ischemia-induced changes in phosphodiesterase (PDE), changes in the membranous binding sites of rolipram, a cAMP-selective PDE inhibitor, were examined in the gerbil brain following transient 5 min forebrain ischemia. Coinciding with the delayed neuronal death (DND) in the hippocampal CA1 region, affinities for cerebral rolipram bindings decreased on Day 4, when intrinsic cAMP, substrate for PDE, might increase. The number of rolipram binding sites was significantly reduced in the hippocampus on Day 14, despite the lack of change on Day 4. This reduction in rolipram binding was in agreement with the previously reported late onset reduction of muscarinic receptors, progressing more slowly than DND. Slowly progressive mechanisms may be involved in the ischemia-induced reduction of the hippocampal rolipram binding sites which may be PDEs

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  • ドキサゾシン投与において脳血流増加を認めた脳梗塞合併高血圧症の一例 査読

    山本光利, 浅沼幹人, 小川紀雄

    臨床と研究   70 ( 9 )   2975 - 2978   1993年9月

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    掲載種別:研究論文(学術雑誌)  

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  • Abnormalities in muscarinic cholinergic receptors and their G-protein coupling systems in the cerebral frontal cortex in Alzheimer's disease 査読

    Norio Ogawa, Kiminao Mizukawa, Masato Asanuma, Ichiro Kanazawa

    Archives of Gerontology and Geriatrics   17 ( 2 )   77 - 89   1993年9月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/0167-4943(93)90040-o

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  • Rapid response of striatal muscarinic M1-receptor mRNA to muscarinic cholinergic agents in rat brain 査読

    Hsi-hsien Chou, Norio Ogawa, Masato Asanuma, Hiroshi Hirata, Yoichi Kondo, Akitane Mori

    Molecular Brain Research   19 ( 3 )   211 - 214   1993年8月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/0169-328x(93)90028-n

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  • 脊髄小脳変性症/生化学的な進歩 招待

    浅沼幹人, 小川紀雄

    Clinical Neuroscience   11 ( 6 )   626 - 629   1993年6月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • Regional changes in neuropeptide levels after 5,7-dihydroxytryptamine-induced serotonin depletion in the rat brain 査読

    Yoichi Kondo, Norio Ogawa, Masato Asanuma, Hiroshi Hirata, Ken-ichi Tanaka, Yoshiro Kawada, Akitane Mori

    Journal of Neural Transmission   92 ( 2-3 )   151 - 157   1993年6月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1007/bf01244874

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  • Effects of the acetylcholinesterase inhibitor ENA-713 on ischemia-induced changes in acetylcholine and aromatic amine levels in the gerbil brain 査読

    Ken-ichi Tanaka, Norio Ogawa, Masato Asanuma, Hiroshi Hirata, Yoichi Kondo, Naoharu Nakayama, Akitane Mori

    Archives Internationales de Pharmacodynamie et de Therapie   323 ( 1-2 )   85 - 96   1993年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ARCH INT PHARMACODYNAMIE  

    The effects of a new acetylcholinesterase inhibitor, ENA-713, on ischemia-induced changes in acetylcholine, monoamines, and their metabolites, were studied in the gerbil. ENA-713 (0.2 mg/kg) or saline was administered intraperitoneally to gerbils 30 min before induction of cerebral ischemia by bilateral carotid occlusion. Pretreatment with ENA-713 mitigated the ischemia-induced abnormalities of the cholinergic, dopaminergic and serotoninergic systems in the gerbil brain, although it had virtually no effect on acetylcholine, monoamines, or their metabolites in any region of the normal gerbil brain. These findings suggest that ENA-713 has beneficial effects against ischemia-induced cerebral disorders. Thus, ENA-713 seems to be promising as a preventive or therapeutic agent for cerebrovascular dementia due to cerebral ischemia and might be useful for the treatment of Alzheimer-type dementia which is associated with multiple neurotransmitter abnormalities in the brain.

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  • 一過性脳虚血後の晩発性ムスカリン性受容体減少に対する免疫抑制剤Cyclosporin Aの阻止効果 査読

    小川紀雄, 浅沼幹人, 近藤洋一, 水川公直, 森 昭胤

    Neurosciences   19 ( 1 )   81 - 84   1993年4月

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  • The preventive effect of cyclosporin A, an immunosuppressant, on the late onset reduction of muscarinic acetylcholine receptors in gerbil hippocampus after transient forebrain ischemia 査読

    Norio Ogawa, Ken-ichi Tanaka, Yoichi Kondo, Masato Asanuma, Kiminao Mizukawa, Akitane Mori

    Neuroscience Letters   152 ( 1-2 )   173 - 176   1993年4月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/0304-3940(93)90511-i

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  • ニユーロトランスミッターのレセプター結合実験法 招待

    浅沼幹人, 小川紀雄

    実験医学   11 ( 3 )   216 - 223   1993年3月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • 脳に対するカルシウム拮抗薬の功罪-カルシウム拮抗薬のドーパミン受容体に対する作用- 招待

    浅沼幹人

    Clinical Calcium   3 ( 3 )   97 - 102   1993年3月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • Amytriptyline投与により無動・姿勢保持障害・歩行障害等の症状改善と同時に前頭葉脳血流低下の著明な改善を認めた進行性核上麻痺の一例 査読

    浅沼幹人, 平田 洋, 近藤洋一, 小川紀雄

    臨床神経学   33 ( 3 )   317 - 321   1993年3月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • Effects of repeated administration of rolipram, a cAMP-specific phosphodiesterase inhibitor, on acetytcholinergic indices in the aged rat brain 査読

    Masato Asanuma, Norio Ogawa, Yoichi Kondo, Hiroshi Hirata, Akitane Mori

    Archives of Gerontology and Geriatrics   16 ( 2 )   191 - 198   1993年3月

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    担当区分:筆頭著者   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/0167-4943(93)90009-7

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  • Cholinergic deficits in aged rat brain are corrected with nicergoline 査読

    Norio Ogawa, Masato Asanuma, Hiroshi Hirata, Yoichi Kondo, Yoshiro Kawada, Akitane Mori

    Arch Gerontol Geriatr   16 ( 2 )   103 - 110   1993年3月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/0167-4943(93)90001-x

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  • 大腸ファイバー検査直後よりwearing off現象の著明な改善のみられたParkinson病 査読

    近藤洋一, 平田 洋, 浅沼幹人, 小川紀雄, 太田善介

    神経内科   38 ( 3 )   291 - 292   1993年3月

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    掲載種別:研究論文(学術雑誌)  

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  • 脳血管障害後遺症に対する塩酸ビフェメラン長期投与の効果 査読

    浅沼幹人, 平田 洋, 近藤洋一, 小川紀雄

    臨床と研究   70 ( 2 )   572 - 576   1993年2月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • Effects of chronic ceruletide treatment on dopamine neurotransmitters, receptors and their mRNAs in the striatum of rats with dyskinesia induced y iminodipionitrile. 査読

    Hiroshi Hirata, Norio Ogawa, Masato Asanuma, Zensuke Ota, Akitane Mori

    Brain Res.   604 ( 1-2 )   197 - 204   1993年2月

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  • Ischemia-induced changes in α-tubulin and β-actin mRNA in the gerbil brain and effects of bifemelane hydrochloride 査読

    Masato Asanuma, Norio Ogawa, Hiroshi Hirata, Hsi-hsien Chou, Yoichi Kondo, Akitane Mori

    Brain Research   600 ( 2 )   243 - 248   1993年1月

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    担当区分:筆頭著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/0006-8993(93)91379-7

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  • 脳血管障害総論/脳神経化学の進歩 招待

    小川紀雄, 浅沼幹人, 近藤洋一

    日本臨床   51(1993年増刊上巻)   61 - 68   1993年

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    掲載種別:研究論文(学術雑誌)  

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  • 塩酸ビフェメラン投与にて前頭葉の血流改善と感情失禁の改善を認めた脳梗塞の一例 査読

    山本光利, 浅沼幹人, 小川紀雄

    日本老年医学会雑誌   30 ( 1 )   70 - 73   1993年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3143/geriatrics.30.70

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  • Degeneration of dopaminergic neurons and free radicals: Possible participation of levodopa 査読

    Norio Ogawa, Rei Edamatsu, Kiminao Mizukawa, Masato Asanuma, Masahiro Kohno, Akitane Mori

    Advances in Neurology   60   242 - 250   1993年

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    記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)   出版者・発行元:RAVEN PRESS  

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  • Comparison of the effects of bifemelane hydrochloride, idebenone and indeloxazine jydrochloride on ischemia-induced changes in brain monoamines and their metabolites in gerbils. 査読

    Kumiko Haba, Norio Ogawa, Masato Asanuma, Hiroshi Hirata, Akitane Mori

    Journal of Neural Transmission   88 ( 3 )   187 - 198   1992年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/bf01244732

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  • Opposite effects of rough and gentle handling with repeated saline administration on c-fos mRNA expression in the rat brain 査読

    Masato Asanuma, Norio Ogawa, Hiroshi Hirata, Hsi-hsien Chou, Ken-ichi Tanaka, Akitane Mori

    Journal of Neural Transmission   90 ( 3 )   163 - 169   1992年10月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1007/bf01250958

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  • Muscarinic cholinergic receptor-mediated modulation on striatal c-fos mRNA expression induced by levodopa in rat brain 査読

    Hsi-hsien Chou, Norio Ogawa, Masato Asanuma, Hirata Hirata, Akitane Mori

    Journal of Neural Transmission   90 ( 3 )   171 - 181   1992年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1007/bf01250959

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  • Post-ischemic administration of bifemelane hydrochloride prohibits ischemia-induced depletion of the muscarinic M1-receptor and its mRNA in the gerbil hippocampus. 査読

    Norio Ogawa, Masato Asanuma, Kiminao Mizukawa, Hirata Hirata, Hsi-hsien Chou, Akitane Mori

    Brain Research   591 ( 1 )   171 - 175   1992年9月

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  • Effects of chronic codergocrine mesylate administration on the brain somatostatinergic system in aged rats 査読

    Ken-ichi Tanaka, Norio Ogawa, Masato Asanuma, Hiroshi Hirata, Yoichi Kondo, Hsi-hsien Chou, Akitane Mori

    Archives of Gerontology and Geriatrics   15 ( 2 )   133 - 139   1992年9月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/0167-4943(92)90013-t

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  • 長期パーキンソン病患者に対するタンパク質摂取制限療法の効果,副作用および適応に関する検討 査読

    平田 洋, 浅沼幹人, 近藤洋一, 小川紀雄

    臨床神経学   32 ( 9 )   973 - 978   1992年9月

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  • 薬物療法-L-DOPAを中心に 招待

    浅沼幹人, 小川紀雄

    MEDICO   23 ( 7 )   9997 - 10001   1992年7月

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  • Effects of chronic catecholamine depletions on muscarinic M1-receptor and its mRNA in rat brain 査読

    Masato Asanuma, Norio Ogawa, Kumiko Haba, Hiroshi Hirata, Akitane Mori

    Journal of the Neurological Sciences   110 ( 1-2 )   205 - 214   1992年7月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/0022-510x(92)90029-k

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  • Effects of dihydroergotoxine on central cholinergic neuronal systems and discrimination learning test in aged rats 査読

    Norio Ogawa, Masahiko Nomura, Kumiko Haba, Masato Asanuma, Ken-ichi Tanaka, Koji Hori, Akitane Mori

    Brain Research   586 ( 2 )   229 - 234   1992年7月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/0006-8993(92)91631-n

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  • Effects of chronic bifemelane hydrochloride administration on receptors for N-methyl-d-aspartate in the aged-rat brain 査読

    Norio Ogawa, Kiminao Mizukawa, Kumiko Haba, Masato Asanuma, Akitane Mori

    Neurochemical Research   17 ( 7 )   687 - 691   1992年7月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1007/bf00968006

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  • 脳梗塞後遺症における脳循環改善薬の有効症状スペクトラムの比較

    小川紀雄, 浅沼幹人, 平田 洋, 近藤洋一

    Prog. Med.   12 ( 6 )   1337 - 1344   1992年6月

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  • Age-Related Changes in Cerebrospinal Fluid γ-Aminobutyric Acid Concentration 査読

    Haruhiko Takayama, Norio Ogawa, Mitsutoshi Yamamoto, Masato Asanuma, Hiroshi Hirata, Zensuke Ota

    Clinical Chemistry and Laboratory Medicine   30 ( 5 )   1992年5月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Walter de Gruyter GmbH  

    DOI: 10.1515/cclm.1992.30.5.271

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  • Late onset and long-lasting suppressive effects of ceruletide, an analogue of cholecystokinin, on c-fos mRNA expression in the rat striatum 査読

    Masato Asanuma, Norio Ogawa, Hiroshi Hirata, Kumiko Haba, Hsi-hsien Chou, Akitane Mori

    Neuroscience Letters   138 ( 2 )   233 - 236   1992年4月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/0304-3940(92)90922-t

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  • Effects of propentophylline on ischemia induced loss of muscarinic cholinergic receptor binding in the gerbil hippocampus 査読

    Hiroshi Hirata, Norio Ogawa, Kumiko Haba, Masato Asanuma, Hsi-hsien Chou, Akitane Mori

    Research Communications in Chemical Pathology and Pharmacology   75 ( 3 )   365 - 368   1992年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:P J D PUBLICATIONS LTD  

    Super-delayed loss of muscarinic-1 (M1) receptors and the protective effect of propentofylline on these changes were examined in the gerbil hippocampus after transient ischemia with radioactive pirenzepine. M1 receptors were markedly decreased in the gerbil hippocampus 14 days after transient ischemia. Single administration of propentofylline (20mg/kg, ip) just after transient ischemia almost completely prevented the ischemia-induced decrease in the number of M1 receptors, and had no effect in sham-operated controls. These findings suggest that one of the therapeutic efficacies of propentofylline is the result of the normalization of the dysfunction of the acetylcholine neuronal system in cerebrovascular disease.

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  • 多発性脳梗塞におけるnicergolineの臨床効果と123I-IMP SPECT上の脳血流改善

    小川紀雄, 浅沼幹人, 平田 洋, 太田善介

    臨床と研究   69 ( 3 )   949 - 957   1992年3月

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    掲載種別:研究論文(学術雑誌)  

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  • Changes of neuropeptides and their receptors in experimental stroke gerbil brains 査読

    Kumiko Haba, Norio Ogawa, Masato Asanuma, Hiroshi Hirata, Yukiko H. Sora, Akitane Mori

    Journal of the Neurological Sciences   108 ( 1 )   88 - 92   1992年3月

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  • Development of a Simple Spasticity Quantification Method: Effects of Tizanidine on Spasticity in Patients with Sequelae of Cerebrovascular Disease 査読

    Norio Ogawa, Masato Asanuma, Hiroshi Hiraata, Zensuke Ota, Yasuhide Yamawaki, Mitsutoshi Yamamoto

    Journal of International Medical Research   20 ( 1 )   78 - 86   1992年2月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:SAGE Publications  

    A simple method that can be performed at the bedside using a spring balance was developed in order to quantify spasticity. The effects of tizanidine on spasticity were evaluated in 30 patients with sequelae of cerebrovascular disease using this method. Treatment with tizanidine was effective in 60% of the patients; there were high correlations between spasticity before and after tizanidine administration and the severity of symptoms and also between the degree of improvement in spasticity and in that of the symptoms. Atonic seizures, due to overdose of tizanidine, were observed in only one patient. The simple spasticity quantification method developed was useful for monitoring tizanidine administration in order to prevent drug overdose. The method appears to be very useful for evaluating the degree of spasticity at the bedside and in measuring the effects of antispastic drugs.

    DOI: 10.1177/030006059202000109

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  • Effects of chronic administration of lisuride hydrogen maleate on aromatic amine and metabolite levels in the gerbil brain following bilateral common carotid ligation 査読

    Hiroshi Hirata, Norio Ogawa, Kumiko Haba, Masato Asanuma, Hsi-hsien Chou, Akitane Mori

    Archives Internationales de Pharmacodynamie et de Therapie   315 ( 1-2 )   5 - 15   1992年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ARCH INT PHARMACODYNAMIE  

    Cerebral monoaminergic neurotransmitters and their metabolites show various concentration changes in gerbils following bilateral carotid ligation. The present study evaluated the effect of chronic administrations of lisuride hydrogen maleate (lisuride) on these changes. Lisuride (0.01 mg/kg or 0.05 mg/kg) or vehicle was intraperitoneally administered to gerbils for 14 consecutive days before the induction of a 30 min ischemia by bilateral carotid ligation. Animals were sacrified immediately and the levels of dopamine, DOPAC, homovanillic acid, noradrenaline, serotonin and 5-hydroxyindoleacetic acid determined by HPLC in the striatum, cortex, hippocampus and diencephalon/midbrain. Lisuride itself had no effect on any compound determined in any region. In the carotid-ligated gerbil brain, however, lisuride corrected the reduction of dopamine in the striatum, normalized or reduced increases in the (DOPAC + homovanillic acid)/dopamine ratio in the striatum, hippocampus and diencephalon/midbrain, and increased the levels of serotonin in all four regions. The present study, together with previous reports, indicate that lisuride may interfere with ischemia-induced cerebrovascular disturbances and, in such a way, improve some pathological sequelae of cerebrovascular disease.

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  • Lisuride hydrogen maleateによる老齢ラット脳ムスカリン性アセチルコリンレセプターの改善-定量的レセプター・オートラジオグラフィー法による検討- 査読

    高山晴彦, 浅沼幹人, 水川公直, 平田 洋, 佐藤博彦, 太田善介, 小川紀雄

    日本老年医学会雑誌   29 ( 1 )   24 - 28   1992年1月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3143/geriatrics.29.24

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  • 超高齢者の脳血管障害後遺症に対する脳代謝改善薬の有効症状のプロフィールの相違

    浅沼幹人, 平田 洋, 高山晴彦, 更井哲夫, 小川紀雄

    臨床と研究   69 ( 1 )   265 - 275   1992年1月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • Effects of bifemelane hydrochloride on loss of N-methyl-D-aspartate receptor and muscarinic cholinergic receptor binding in the gerbil hippocampus after transient ischemia 査読

    Masato Asanuma, Norio Ogawa, Kumiko Haba, Hiroshi Hirata, Hsi-hsien Chou, Akitane Mori

    Archives Internationales de Pharmacodynamie et de Therapie   315 ( 1-2 )   16 - 21   1992年1月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ARCH INT PHARMACODYNAMIE  

    The effects of bifemelane hydrochloride on changes of N-methyl-D-aspartate receptors and muscarinic cholinergic receptors were examined in the gerbil hippocampus after transient ischemia with radioactive-specific ligands. There were marked reductions in both these receptors in the gerbil hippocampus 14 days after transient ischemia, without changes in the respective affinities. Post-ischemia bifemelane treatment almost completely prevented the ischemia-induced decreases in the numbers of these receptors, and had no effect in sham-operated controls. The results of the present study suggest that this drug prevents postsynaptic dysfunction induced by transient ischemia, and may be useful in the therapy of both the chronic and the acute stage of cerebrovascular disease.

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  • Distinction between declarative memory and procedural memory using 8-arm radial maze task : Biphasic effects of thyrotropin reloading hormone on scopolamine-induced amnesia. 査読

    Norio Ogawa, Masato Asanuma, Hiroshi Hirata, Hsi-hsien Chou, Yoichi Kondo, Setsuko Ogawa, Akitane Mori

    Research Communications in Psysiology, Psychiatry and Behavior   17 ( 1-2 )   1 - 15   1992年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Distribution of the beta-2 adrenergic receptor messenger RNA in the rat brain by in situ hybridization histochemistry: Effects of chronic reserpine treatment 査読

    Masato Asanuma, Norio Ogawa, Kiminao Mizukawa, Kumiko Haba, Hiroshi Hirata, Akitane Mori

    Neurochemical Research   16 ( 12 )   1253 - 1256   1991年12月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1007/bf00966654

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  • Calcium antagonist flunarizine hydrochloride affects striatal D2 dopamine receptors in the young adult and aged rat brain 査読

    Masato Asanuma, Norio Ogawa, Kumiko Haba, Hiroshi Hirata, Akitane Mori

    Archives of Gerontology and Geriatrics   13 ( 3 )   271 - 278   1991年11月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/0167-4943(91)90049-v

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  • ソマトスタチン減少剤 招待

    浅沼幹人, 小川紀雄

    生体の科学   42 ( 5 )   505 - 506   1991年10月

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    担当区分:筆頭著者, 責任著者   記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.11477/mf.2425900277

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  • Effects of beta-adrenergic blocking agents on specific binding of [3H]D-Ala2-Met5-enkephalinamide and [3H]naloxone. 査読

    Haruhiko Takayama, Norio Ogawa, Masato Asanuma, Hiroshi Hirata, Toshio Ogura, Zensuke Ota

    Acta Medica Okayama   45 ( 5 )   295 - 299   1991年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Okayama University Medical School  

    <p>To gain further insight into the central nervous system (CNS)-action of beta-adrenergic blocking agents (beta-blockers), we examined the effects of various kinds of beta-blockers on opioid receptors (Op-Rs) using radiolabeled receptor assay (RRA). We demonstrated that beta-blockers are competitively bound to Op-Rs in the CNS. Sodium index of beta-blockers in [3H]naloxone binding study indicated that beta-blockers had the mixed agonist-antagonist activity of opiates. The relative potency of beta-blockers in opioid RRA was negatively correlated with their membrane stabilizing activity. Neither beta-blocking activity nor intrinsic sympathomimetic activity was correlated with IC50 values of beta-blockers in opioid RRA. While it is widely accepted that beta-blockers have a tranquilizing activity, a part of the tranquilizing action of beta-blockers may be mediated through Op-Rs in the CNS. Although beta-blockers may have effects on their own receptors (beta-receptors) in the CNS, the more precise mechanisms of central action of these drugs must be further investigated.</p>

    DOI: 10.18926/AMO/32199

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  • Dopamine deficiency in the Weaver mutant mouse: An animal model of olivopontocerebeller atrophy 査読

    Hsi-hsien Chou, Norio Ogawa, Masato Asanuma, Hiroshi Hirata, Akitane Mori

    Research Communications in Chemical Pathology and Pharmacology   74 ( 1 )   117 - 120   1991年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:P J D PUBLICATIONS LTD  

    The dopamine system in weaver mutant mice, a model of cerebellar atrophy, was studied. Dopamine levels of 6-week-old weaver mice were 37%, 44%, 34%, and 41% of levels in age-matched controls in the cerebral cortex, hippocampus, septal region and striatum, respectively. Noradrenaline levels did not differ from controls. This study shows that weaver mice have specific deficiencies in the dopamine system.

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  • Long-lasting effect of ceruletide on dyskinesia and monoaminergic neuronal pathways in rats treated with iminodipropionitrile 査読

    Norio Ogawa, Kumiko Haba, Masato Asanuma, Akitane Mori

    Brain Research   556 ( 2 )   271 - 279   1991年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/0006-8993(91)90315-m

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  • 神経伝達物質とパーキンソン病 招待

    浅沼幹人, 小川紀雄

    臨床成人病   21 ( 7 )   1191 - 1199   1991年7月

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    担当区分:筆頭著者, 責任著者   記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Chronic Lisuride Hydrogen Maleate Administration Enhances Muscarinic Receptor Binding in Senescent Rat Brain 査読

    Hiroshi Hirata, Norio Ogawa, Kiminao Mizukawa, Kumiko Haba, Masato Asanuma, Akitane Mori, Zensuke Ota

    Journal of International Medical Research   19 ( 4 )   318 - 325   1991年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SAGE Publications  

    Changes in the regional density of muscarinic-1 (M1) receptors and the effect of lisuride hydrogen maleate on these changes were studied in senescent rat brain by in vitro autoradiography. In young adult controls, M1 receptor binding was most dense in the striatum and hippocampus, followed by the cerebral cortex and amygdala. Binding to M1 receptors was markedly lower in these areas of the senescent brain compared with the young adult brain. These decreases were reversed by intraperitoneal administration of 50 μg/kg·day lisuride for 14 days. The present results indicate that the therapeutic efficacy of lisuride depends on normalization of not only monoamine systems but also acetylcholine systems.

    DOI: 10.1177/030006059101900404

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  • 脳血管障害後遺症における意欲低下・問題行動に対する塩酸インデロキサジンの改善効果

    浅沼幹人, 平田 洋, 高山晴彦, 更井哲夫, 小川紀雄

    Prog. Med.   11 ( 6 )   1527 - 1530   1991年6月

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    担当区分:筆頭著者, 責任著者   記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • イブジラストの脳梗塞症例における脳血流改善作用-SPECTを用いて-

    高山晴彦, 浅沼幹人, 佐藤博彦, 平田 洋, 太田善介, 小川紀雄

    臨床と研究   68 ( 6 )   1857 - 1862   1991年6月

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  • Loss of N-methyl-d-aspartate (NMDA) receptor binding in rat hippocampal areas at the chronic stage after transient forebrain ischemia: Histological and NMDA receptor binding studies 査読

    Norio Ogawa, Kumiko Haba, Kiminao Mizukawa, Masato Asanuma, Hiroshi Hirata, Akitane Mori

    Neurochemical Research   16 ( 5 )   519 - 524   1991年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1007/bf00974869

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    その他リンク: http://link.springer.com/article/10.1007/BF00974869/fulltext.html

  • Chronic bifemelane hydrochloride administration enhances muscarinic cholinergic recepotr binding in the senescent rat brain 査読

    Norio Ogawa, Kiminao Mizukawa, Kumiko Haba, Masato Asanuma, Akitane Mori

    Journal of Medicine   22 ( 1 )   17 - 27   1991年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:P J D PUBLICATIONS LTD  

    In senescent rats, the binding ability of muscarinic cholinergic receptors (MCR) was markedly decreased in the cerebral cortex, hippocampus, thalamus, and the striatum compared with young adult rats. This decrease was markedly improved by chronic administration of bifemelane hydrochloride (bifemelane). In view of the findings that bifemelane markedly inhibits the decrease in acetylcholine (ACh) associated with cerebral ischemia, and that it improves amnesia induced by scopalamine, it may be inferred that bifemelane between in situ malignant melanoma and other melanin-containing in situ malignancies has been presented. All types of malignant melanoma which originate within the epidermis or epithelium have an in situ phase and show horizontal growth, and small early forms defy classification. The classification of the most common types of malignant melanoma has been revised. Although the level of invasion and tumor thickness are useful prognostic and therapeutic parameters, their determination is crude and subject to several shortcomings.

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  • レセルピン慢性投与のアセチルコリン系神経機構に及ぼす影響 査読

    浅沼幹人, 羽場久美子, 小川紀雄, 森 昭胤

    Neurosciences   17 ( 1 )   87 - 90   1991年1月

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    担当区分:筆頭著者   掲載種別:研究論文(学術雑誌)  

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  • パーキンソン病 招待

    浅沼幹人, 小川紀雄

    Brain Medical   3 ( 4 )   351 - 358   1991年

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    担当区分:筆頭著者, 責任著者   記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Super-delayed changes of muscarinic acetylcholine receptor in the gerbil hippocampus following transient ischemia. 査読

    Norio Ogawa, Kumiko Haba, Masato Asanuma, Kiminao Mizukawa, Akitane Mori

    Advances in Experimental Medicine and Biology   287   343 - 347   1991年

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    記述言語:英語   掲載種別:論文集(書籍)内論文  

    DOI: 10.1007/978-1-4684-5907-4_28

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  • 老齢ラット脳におけるソマトスタチン・レセプターの減少と塩酸bifemelane投与による増加作用-レセプター・オートラジオグラフィー法による検討-

    佐藤博彦, 水川公直, 小川紀雄, 浅沼幹人, 太田善介

    日本老年医学会誌   28 ( 1 )   18 - 23   1991年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3143/geriatrics.28.18

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  • 神経ペプチドとレセプター 招待

    小川紀雄, 浅沼幹人, 羽場久美子

    内分泌学の進歩   8   55 - 74   1991年

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    記述言語:日本語   掲載種別:論文集(書籍)内論文  

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  • Regional responses of rat brain opioid receptors upon castration and testosterone replacement 査読

    Haruhiko Takayama, Norio Ogawa, Masato Asanuma, Zensuke Ota

    Research Communications in Chemical Pathology and Pharmacology   70 ( 3 )   355 - 358   1990年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:P J D PUBLICATIONS LTD  

    Regional responses of rat brain opioid receptors (Op-Rs) upon castration and testosterone replacement were studied using [H-3]naloxone (NAL) binding for u-type and [H-3]D-Ala2-methionine-enkephalin (ENK) binding for delta-type Op-R. Castration itself produced an increase in specific NAL and ENK binding in the olfactory bulb and thalamus+midbrain. In the hypothalamus, specific ENK binding was increased without any change in NAL binding. After the testosterone replacement in castrated rats, specific NAL binding was decreased and returned to the control level in the thalamus+midbrain, but remained high in the olfactory bulb. Specific ENK binding was decreased and returned to the control level in the olfactory bulb, hypothalamus and thalamus+midbrain. These results indicated that there are regional differences between u- and delta-type Op-R responses to castration and testosterone replacement. Op-R subtypes were regulated differentially by endogenous hormonal changes, such as testosterone.

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  • 老齢ラットにおけるNMDAレセプターの減少とBifemelane Hydrochloride投与による回復

    小川紀雄, 水川公直, 羽場久美子, 浅沼幹人

    Geriat. Med.(老年医学)   28 ( 12 )   1845 - 1849   1990年12月

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    担当区分:最終著者   記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Alterations of somatostatin and its modulation by levodopa in MPTP-treated mouse brain 査読

    Masato Asanuma, Norio Ogawa, Yukiko H. Sora, Khitisak Pongdhana, Kumiko Haba, Akitane Mori

    Journal of the Neurological Sciences   100 ( 1-2 )   155 - 160   1990年12月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/0022-510x(90)90027-k

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  • Effects of chronic administration of mergocryptine on changes in neurotransmitter levels in the ischemic gerbil brain. 査読

    Norio Ogawa, Kumiko Haba, Masato Asanuma, Mitsuhiro Kawata, Akitane Mori

    Archives Internationales de Pharmacodynamie et de Therapie   308 ( 1-2 )   21 - 31   1990年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ARCH INT PHARMACODYNAMIE  

    Changes in various neurotransmitter systems of the gerbil brain during ischemia and the effects of administration of mergocryptine, a new ergot derivative, were studied. Gerbils intraperitoneally administered 0.5 mg/kg of mergocryptine or the vehicle once a day for 14 days were used. The administration of mergocryptine to control animals had no effect on the contents of neurotransmitters or their metabolites in various regions of the brain, but it corrected abnormalities in the neurotransmitter systems caused by ischemia. These results suggest the usefulness of mergocryptine against the deleterious effects of brain ischemia.

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  • 塩酸フルナリジンの線条体D2ドーパミンレセプターに対する作用 査読

    小川紀雄, 浅沼幹人, 高山晴彦, 佐藤博彦, 貫名 至

    臨床神経学   30 ( 11 )   1221 - 1226   1990年11月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Comparison of formaldehyde-preperfused frozen and freshly frozen tissue preparation for the in situ hybridization for alpha-tubulin messenger RNA in the rat brain 査読

    Masato Asanuma, Norio Ogawa, Kiminao Mizukawa, Kumiko Haba, Akitane Mori

    Research Communications in Chemical Pathology and Pharmacology   70 ( 2 )   183 - 192   1990年11月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:P J D PUBLICATIONS LTD  

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  • ニューロトランスミッターとドプス-パーキンソン病治療薬としての基礎と臨床- 招待

    小川紀雄, 浅沼幹人

    薬の知識   41 ( 3 )   3 - 8   1990年3月

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    担当区分:最終著者   記述言語:日本語   掲載種別:研究論文(その他学術会議資料等)  

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  • 老齢ラット脳におけるアセチルコリン系神経機構障害とnicergolineによる補正

    小川紀雄, 水川公直, 羽場久美子, 浅沼幹人

    Geriat. Med.(老年医学)   27 ( 8 )   1198 - 1204   1989年8月

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    担当区分:最終著者   記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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書籍等出版物

  • 生命金属ダイナミクス 生体内における金属の挙動と制御

    浅沼幹人, 宮崎育子( 担当: 分担執筆 ,  範囲: パーキンソン病と亜鉛結合蛋白. pp304-309)

    エヌ・ティー・エス,東京  2021年 

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  • 脳内環境辞典

    浅沼幹人, 宮崎育子( 担当: 分担執筆 ,  範囲: Nrf2. pp122-123)

    メディカルドウ,大阪  2017年 

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  • 脳内環境-維持機構と破綻がもたらす疾患研究

    浅沼幹人, 宮崎育子( 範囲: アストロサイトの部位特異的プロファイルがもたらす脳内環境と神経保護.pp102-107)

    メディカルドウ,大阪  2014年 

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  • 腎とフリーラジカル第10集

    浅沼幹人( 担当: 分担執筆 ,  範囲: 酸化ストレスの評価のpitfall─神経科学からの話題.pp32-35)

    東京医学社,東京  2010年 

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  • 実験薬理学 実践行動薬理学

    北村佳久, 浅沼幹人, 宮崎育子, 四宮一昭, 五味田裕( 担当: 分担執筆 ,  範囲: 視床下部─下垂体─副腎皮質系過活動モデルを用いた治療抵抗性うつ病モデルの作製および創薬への応用. pp138-146)

    金芳堂,京都  2010年 

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  • Handbook of Free Radicals: Formation, Types and Effects

    Ikuko Miyazaki, Masato Asanuma( 担当: 分担執筆 ,  範囲: Antioxidative and neuroprotective effects of metallothioneins on dopaminergic neurons. pp557-568)

    Nova Science Publishers, New York  2010年 

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  • 酸化ストレス─フリーラジカル医学生物学の最前線 Ver.2

    宮崎育子, 浅沼幹人( 担当: 分担執筆 ,  範囲: カテコールアミン神経特異的酸化ストレスとしてのキノン体毒性とその防御. pp241-244)

    医歯薬出版,東京  2006年 

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  • Immunosuppressant Analogs in Neuroprotection

    Ken-ichi Tanaka, Masato Asanuma, Norio Ogawa( 担当: 分担執筆 ,  範囲: Blockade of late-onset reduction of muscarinic acetylcholine receptors by immunosuppressants in forebrain ischemia. pp215-229)

    Humana Press, Totowa  2003年 

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  • 酸化ストレス─フリーラジカル医学生物学の最前線

    浅沼幹人, 小川紀雄( 担当: 分担執筆 ,  範囲: 酸化ストレスによる神経障害とその防御. pp177-181)

    医歯薬出版  2001年 

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  • 脊髄小脳変性症の臨床

    浅沼幹人, 小川紀雄( 担当: 分担執筆 ,  範囲: 脊髄小脳変性症の病態薬理化学. pp87-93)

    新興医学出版社  1999年 

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  • Free radicals in brain physiology and disorders.

    Norio Ogawa, Emi Iwata, Masato Asanuma, Sakiko Nishibayashi, Kyoko Iida( 担当: 分担執筆 ,  範囲: Oxidative stress and transcription factors. pp131-140)

    Academic Press, San Diego  1996年 

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  • 活性酸素とバイオシグナル

    浅沼幹人, 西林佐紀子, 小川紀雄( 担当: 分担執筆 ,  範囲: 神経機能制御と活性酸素代謝. pp150-166.)

    講談社サイエンティフィック、東京  1996年 

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  • 新しいSCDの臨床、脊髄小脳変性症の臨床

    小川紀雄, 浅沼幹人( 担当: 分担執筆 ,  範囲: 脊髄小脳変性症の薬理化学的特徴と薬物治療. pp53-58)

    新興医学出版社、東京  1996年 

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  • レセプター:基礎と臨床

    小川紀雄, 浅沼幹人( 担当: 分担執筆 ,  範囲: TRHレセプター, ソマトスタチンレセプター pp546-551)

    朝倉書店、東京  1993年 

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  • 痴呆の基礎研究、高年期の痴呆シリーズ

    浅沼幹人, 小川紀雄( 担当: 分担執筆 ,  範囲: 痴呆と神経伝達物質・レセプター. pp161-181)

    中央法規出版、東京  1993年 

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  • Parkinson's Disease. From Aspects to Molecular Basis., Key Topics in Brain Research

    Norio Ogawa, Masato Asanuma( 担当: 分担執筆 ,  範囲: Receptor alterations in Parkinson's disease. pp39-51)

    Springer-Verlag, Wien  1991年 

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  • Neuroreceptor Mechanisms in Brain

    Norio Ogawa, Kumiko Haba, Masato Asanuma, Kiminao Mizukawa, Akitane Mori( 担当: 分担執筆 ,  範囲: Super-delayed changes of muscarinic acetylcholine receptor in the gerbil hippocampus following transient ischemia. pp343-347)

    Plenum Publishing Corporation, New York  1991年 

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▼全件表示

MISC

  • メタロチオネイン発現を誘導するアストロサイトのセロトニン1A 受容体刺激による神経突起伸長作用の検討.

    浅沼幹人, 一瀬愛花, 三澤一華, 小川賢透, 進浩太郎, 宮崎育子

    日本毒性学会生体金属部会メタルバイオサイエンス研究会2023抄録集   2023年10月

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    担当区分:筆頭著者, 責任著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • 危険ドラッグの神経細胞毒性発現の蓋然性スクリーニングにむけた標的生体分子系の探索. シンポジウム: 危険ドラッグにおける乱用‧流通規制の現状と研究の最前線

    浅沼幹人

    第53回日本神経精神薬理学会年会抄録集   2023年9月

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    担当区分:筆頭著者, 最終著者, 責任著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • パーキンソン病の環境要因農薬ロテノンによる中脳ドパミン神経障害とαシヌクレイン発現へのグリア部位特異性の関与.

    宮崎育子, 菊岡 亮, 磯岡奈未, 十川千春, 十川紀夫, 北村佳久, 浅沼幹人

    第53回日本神経精神薬理学会年会抄録集   2023年9月

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    担当区分:最終著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • おもり自由落下装置による,高い再現性を有する慢性外傷性脳症モデルの作製

    菅原千明, 安原隆雄, 平山隆浩, 正井加織, 佐々田晋, 金恭平, 河内哲, 藪野諭, 永瀬喬之, 佐々木達也, 内藤宏道, 浅沼幹人, 伊達勲

    日本分子脳神経外科学会プログラム・抄録集   23rd   2023年8月

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    記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

    J-GLOBAL

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  • ロテノン曝露による中脳神経細胞におけるαシヌクレイン発現誘導と神経障害へのグリア細胞部位特異性の関与.

    宮崎育子, 菊岡 亮, 磯岡奈未, 十川千春, 十川紀夫, 北村佳久, 浅沼幹人

    第17回パーキンソン病・運動障害疾患コングレス(MDSJ) 抄録集   2023年7月

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    担当区分:最終著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • ストレプトゾトシン脳室内投与孤発性アルツハイマー病モデルマウスにおけるグリア細胞活性化の領域特異性.

    正井加織, 中山裕太, 進浩太郎, 宮崎育子, 浅沼幹人

    第64回日本神経病理学会総会学術研究会・第66回日本神経化学会大会合同大会抄録集   2023年7月

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    担当区分:最終著者, 責任著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • 部位特異的アストロサイト−ミクログリア連関がもたらすドパミン神経障害.シンポジウム: ミクログリア毒性学

    宮崎育子, 浅沼幹人

    第50回日本毒性学会学術年会抄録集   2023年6月

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    担当区分:最終著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • Mesencephalic glia contributes to alpha-synuclein expression and neurotoxicity in parkinsonian model

    Miyazaki, I, Kikuoka, R, Isooka, N, Sogawa, C, Sogawa, N, Kitamura, Y, Asanuma, M

    第64回日本神経学会学術大会抄録集   2023年6月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • 中脳神経細胞におけるαシヌクレイン発現とロテノン誘発神経障害へのグリア細胞部位特異性の関与.

    宮崎育子, 菊岡 亮, 磯岡奈未, 十川千春, 十川紀夫, 北村佳久, 浅沼幹人

    第128回日本解剖学会総会・全国学術集会抄録集   2023年3月

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    担当区分:最終著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • 脳・腸神経変性を再現できるパーキンソン病モデルにおける腸管バリア機能の破綻,炎症反応.

    浅沼幹人, 宮崎育子, 進 浩太郎, 都 明希, 小林壯太朗, 津田光希, 小野鈴香, 小川賢透, 正井加織

    第128回日本解剖学会総会・全国学術集会抄録集   2023年3月

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    担当区分:筆頭著者, 責任著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • おもり自由落下装置を用いた慢性頭部外傷性脳症モデルの作成 高い再現性と定量性を求めて

    菅原 千明, 安原 隆雄, 平山 隆浩, 正井 加織, 佐々田 晋, 河内 哲, 藪野 諭, 永瀬 喬之, 佐々木 達也, 内藤 宏道, 浅沼 幹人, 伊達 勲

    日本脳神経外傷学会プログラム・抄録集   46回   119 - 119   2023年2月

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    記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)   出版者・発行元:(一社)日本脳神経外傷学会  

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  • パーキンソン病モデルにおけるαシヌクレイン発現と神経変性へのグリア細胞部位特異性の関与

    宮崎育子, 菊岡 亮, 磯岡奈未, 十川千春, 十川紀夫, 北村佳久, 浅沼幹人

    第96回日本薬理学会年会・第43回日本臨床薬理学会学術総会抄録集   2022年12月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • パーキンソン病の脳・腸神経変性を再現できるロテノン曝露モデルマウスにおける腸管細胞環境の変化

    浅沼幹人, 宮崎育子, 進 浩太郎, 都 明希, 正井加織, 小林壯太朗, 津田光希, 小野鈴香

    第96回日本薬理学会年会・第43回日本臨床薬理学会学術総会抄録集   2022年12月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • ミルタザピンはアストロサイトの5-HT1A受容体を介したメタロチオネイン発現によりドパミン神経保護効果を示す

    菊岡 亮, 宮崎育子, 久保田菜月, 前田恵実, 香川大樹, 守山雅晃, 佐藤明日香, 村上真樹, 北村佳久, 千堂年昭, 座間味義人, 浅沼幹人

    第96回日本薬理学会年会・第43回日本臨床薬理学会学術総会抄録集   2022年12月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • 神経保護修飾薬の創薬標的となりうるグリア細胞アストロサイトのメタロチオネイン:部会賞受賞講演

    浅沼幹人

    日本毒性学会生体金属部会メタルバイオサイエンス研究会2022抄録集   2022年10月

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    担当区分:筆頭著者, 最終著者, 責任著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • 抜歯後組織修復におけるメタロチオネインの関与

    西田優花, 嶋田勝光, 十川千春, 宮崎育子, 富田美穂子, 蓜島弘之, 浅沼幹人, 村上 聡, 十川紀夫

    日本毒性学会生体金属部会メタルバイオサイエンス研究会2022抄録集   2022年10月

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    記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • パーキンソン病の脳腸病態を再現しうるモデル動物におけるメタロチオネイン発現変化

    宮崎育子, 正井加織, 進 浩太郎, 十川千春, 十川紀夫, 北村佳久, 浅沼幹人

    日本毒性学会生体金属部会メタルバイオサイエンス研究会2022抄録集   2022年10月

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    担当区分:最終著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • パーキンソン病の脳腸病態を再現しうるモデル動物における腸管神経障害機構の検討

    宮崎育子, 小林壯太朗, 津田光希, 都 明希, 小野鈴香, 正井加織, 浅沼幹人

    第16回パーキンソン病・運動障害疾患コングレス(MDSJ)抄録集   2022年7月

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    担当区分:最終著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • Targeting zinc-binding protein metallothionein in astrocytes for dopaminergic neuroprotection.

    Ikuko Miyazaki, Masato Asanuma

    The 8th International Symposium on Metallomics, Abstracts   2022年7月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)  

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  • 農薬ロテノン慢性皮下投与パーキンソン病モデルマウスにおける腸管細胞環境の変化

    浅沼幹人, 宮崎育子, 都 明希, 小林壯太朗, 津田光希, 小野鈴香, 正井加織

    第49回日本毒性学会学術年会抄録集   2022年7月

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    担当区分:筆頭著者, 責任著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • Region-specific astrocyte-microglia interaction promotes rotenone-induced dopaminergic neurotoxicity

    Miyazaki, I, Kikuoka, R, Isooka, N, Murakami, S, Sogawa, C, Sogawa, N, Kitamura, Y, Asanuma, M

    2022年5月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • 農薬ロテノン曝露による部位特異的アストロサイト−ミクログリア相互連関とドパミン神経細胞への影響

    宮崎育子, 菊岡 亮, 磯岡奈未, 村上真樹, 十川千春, 十川紀夫, 北村佳久, 浅沼幹人

    第127回日本解剖学会総会・全国学術集会抄録集   2022年3月

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    担当区分:最終著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • 部位特異的アストロサイト−ミクログリア連関がもたらすロテノン誘発ドパミン神経障害

    宮崎育子, 菊岡 亮, 磯岡奈未, 村上真樹, 十川千春, 十川紀夫, 北村佳久, 浅沼幹人

    第95回日本薬理学会年会抄録集   2022年3月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • ストレプトゾトシン脳室内投与による孤発性アルツハイマー病モデルマウスの行動学的・組織学的検討

    正井加織, 中山裕太, 宮崎育子, 浅沼幹人

    第31回神経行動薬理若手研究者の集い 抄録集   2022年3月

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    担当区分:最終著者, 責任著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • メタロチオネイン欠損による脳梁形成不全の増悪

    正井加織, 菊岡 亮, 名越 武, 十川千春, 十川紀夫, 宮崎育子, 浅沼幹人

    日本解剖学会第75回中国・四国支部学術集会抄録集   2021年10月

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    担当区分:最終著者, 責任著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • アストロサイト−ミクログリア連関を介したロテノン誘発ドパミン神経障害へのメタロチオネインの関与

    宮崎育子, 菊岡 亮, 磯岡奈未, 村上真樹, 十川千春, 十川紀夫, 北村佳久, 浅沼幹人

    日本毒性学会生体金属部会メタルバイオサイエンス研究会2021抄録集   2021年10月

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    担当区分:最終著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • LPS投与による機械的刺激反応閾値低下における金属結合タンパク質メタロチオネインの関与

    十川紀夫, 奥村雅代, 宮崎育子, 富田美穂子, 金銅英二, 十川千春, 浅沼幹人

    日本毒性学会生体金属部会メタルバイオサイエンス研究会2021抄録集   2021年10月

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    担当区分:最終著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • メタロチオネイン欠損マウスにおける脳梁形成不全

    正井加織, 菊岡 亮, 名越 武, 十川千春, 十川紀夫, 宮崎育子, 浅沼幹人

    日本毒性学会生体金属部会メタルバイオサイエンス研究会2021抄録集   2021年10月

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    担当区分:最終著者, 責任著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • 妊娠・授乳期エポキシ樹脂BADGE曝露による新生仔マウス脳発達異常におけるエストロゲンβレセプターの関与

    浅沼幹人, 宮崎育子, 西山千春, 菊岡亮, 名越 武, Kyle Quin, 禅正和真

    第43回日本生物学的精神医学会・第51回日本神経精神薬理学会合同年会プログラム・抄録集   2021年7月

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    担当区分:筆頭著者, 責任著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • アストロサイト-ミクログリア連関がもたらす農薬ロテノン誘発ドパミン神経障害

    宮崎育子, 菊岡 亮, 磯岡奈未, 村上真樹, 十川千春, 十川紀夫, 北村佳久, 浅沼幹人

    第43回日本生物学的精神医学会・第51回日本神経精神薬理学会合同年会プログラム・抄録集   2021年7月

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    担当区分:最終著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • アストロサイトにおけるメタロチオネインを標的としたドパミン神経保護. シンポジウム: 生体金属部会シンポジウム 〜メタロチオネイン機能の新たな展開〜

    宮崎育子, 浅沼幹人

    第48回日本毒性学会学術年会抄録集   2021年7月

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    担当区分:最終著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • 中脳グリア細胞を介したロテノン誘発ドパミン神経特異的神経障害とそのメカニズムに関する検討

    宮崎 育子, 菊岡 亮, 磯岡 奈未, 村上 真樹, 十川 千春, 十川 紀夫, 北村 佳久, 浅沼 幹人

    第15回パーキンソン病・運動障害疾患コングレスプログラム・抄録集   15回   93 - 93   2021年7月

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    担当区分:最終著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)   出版者・発行元:Movement Disorder Society of Japan (MDSJ)  

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  • Rotenone-induced dopaminergic neurotoxicity mediated by astrocyte-microglia interaction

    Miyazaki, I, Kikuoka, R, Isooka, N, Murakami, S, Sogawa, C, Sogawa, N, Kitamura, Y, Asanuma, M

    第62回日本神経学会学術大会プログラム・抄録集   2021年5月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • 妊娠・授乳期エポキシ樹脂曝露による新生仔マウスの脳発達異常へのエストロゲン受容体βの関与

    宮崎育子, 西山千春, 菊岡 亮, 名越 武, Kyle Quin, 磯岡奈未, 禅正和真, 浅沼幹人

    第126回日本解剖学会総会・全国学術集会抄録集   2021年3月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • アストロサイト−ミクログリア連関がもたらすロテノン誘発ドパミン神経障害

    宮崎育子, 菊岡 亮, 磯岡奈未, 十川千春, 十川紀夫, 北村佳久, 浅沼幹人

    第94回日本薬理学会年会抄録集   2021年3月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • 5-HT1Aアゴニストによるアストロサイトのメタロチオネイン発現誘導とドパミン神経保護

    宮崎育子, 磯岡奈未, 菊岡 亮, 北村佳久, 浅沼幹人

    第14回パーキンソン病・運動障害疾患コングレス (MDSJ)プログラム・抄録集   2021年2月

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    担当区分:最終著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • ロテノン誘発ドパミン神経障害におけるアストロサイト−ミクログリア連関

    宮崎育子, 村上真樹, 菊岡 亮, 磯岡奈未, 十川千春, 十川紀夫, 北村佳久, 浅沼幹人

    日本毒性学会生体金属部会メタルバイオサイエンス研究会2020抄録集   2020年11月

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    担当区分:最終著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • パーキンソン病モデルマウスにおける杜仲抽出物のメタロチオネイン発現誘導および神経保護効果

    今福史智, Jin Sun, 磯岡奈未, 上舞 直, 清水崇司, 豊田俊明, 岡本裕成, 菊岡 亮, 宮崎育子, 浅沼幹人

    日本毒性学会生体金属部会メタルバイオサイエンス研究会2020抄録集   2020年11月

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    担当区分:最終著者, 責任著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • パーキンソン病と生体金属, 金属結合蛋白. シンポジウム: 生命金属で切り開く神経疾患の解明

    浅沼幹人

    第61回日本神経学会学術大会プログラム・抄録集   2020年9月

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    担当区分:筆頭著者, 責任著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • Region-specific glial dysfunction promotes rotenone neurotoxicity

    Miyazaki, I, Kikuoka, R, Isooka, N, Sogawa, C, Sogawa, N, Kitamura, Y, Asanuma, M

    第61回日本神経学会学術大会プログラム・抄録集   2020年8月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • 農薬ロテノン曝露によるアストロサイトの部位特異的反応性の差異と神経細胞に及ぼす影響

    宮崎育子, 浅沼幹人, 村上真樹, 菊岡 亮, 磯岡奈未, 十川千春, 十川紀夫, 北村佳久

    第125回日本解剖学会総会抄録集   2020年3月

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    担当区分:責任著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • Glutathione in astrocytes as a target of neuroprotection.シンポジウム: 中枢神経におけるGSH産生促進を介する神経保護機構

    浅沼幹人

    第93回日本薬理学会年会抄録集   2020年3月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • ロテノン投与パーキンソン病モデルにおけるコーヒー成分のメタロチオネイン発現誘導と神経保護効果

    磯岡奈未, 宮崎育子, 和田晃一, 菊岡 亮, 古川智英子, 北村佳久, 浅沼幹人

    日本毒性学会生体金属部会メタルバイオサイエンス研究会2019抄録集   2019年10月

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    担当区分:最終著者, 責任著者  

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  • ロテノン誘発部位特異的アストロサイト機能不全によるドパミン神経障害へのメタロチオネインの関与

    宮崎育子, 浅沼幹人, 村上真樹, 菊岡 亮, 磯岡奈未, 十川千春, 十川紀夫, 北村佳久

    日本毒性学会生体金属部会メタルバイオサイエンス研究会2019抄録集   2019年10月

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    担当区分:責任著者  

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  • 老齢メタロチオネインノックアウトマウスにおける脳組織学的変化

    菊岡 亮, 野村昌紀, 磯岡奈未, 宮崎育子, 十川紀夫, 十川千春, 北村佳久, 浅沼幹人

    日本毒性学会生体金属部会メタルバイオサイエンス研究会2019抄録集   2019年10月

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    担当区分:最終著者, 責任著者  

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  • Involvement of region-specific glial dysfunction in rotenone neurotoxicity

    Miyazaki, I, Asanuma, M, Murakami, S, Kikuoka, R, Isooka, N, Sogawa, C, Sogawa, N, Kitamura, Y

    VI AsCNP2019 Congress Abstract   2019年10月

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    担当区分:責任著者  

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  • ドパミン神経毒による酸化ストレスに対するアストロサイトの分子発現および神経保護作用の部位特異性

    浅沼 幹人, 奥村 菜央, 鳥越, 育子, 村上 真樹, 北村 佳久, 千堂 年昭

    第13回パーキンソン病・運動障害疾患コングレスプログラム・抄録集   13回   118 - 118   2019年7月

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    担当区分:筆頭著者, 責任著者   記述言語:日本語   出版者・発行元:Movement Disorder Society of Japan (MDSJ)  

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  • 部位特異的アストロサイト機能不全がもたらすロテノン誘発ドパミン神経障害

    宮崎 育子, 浅沼 幹人, 村上 真樹, 菊岡 亮, 磯岡 奈未, 十川 千春, 十川 紀夫, 北村 佳久

    第13回パーキンソン病・運動障害疾患コングレスプログラム・抄録集   13回   118 - 118   2019年7月

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    担当区分:責任著者   記述言語:日本語   出版者・発行元:Movement Disorder Society of Japan (MDSJ)  

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  • Regional differences in reaction of astrocytes against rotenone contribute to dopaminergic neurodegeneration

    Miyazaki, I, Asanuma, M, Murakami, S, Kikuoka, R, Isooka, N, Sogawa, C, Sogawa, N, Kitamura, Y

    14th European Meeting on Glial Cells in Health and Disease Congress Abstract   2019年7月

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    担当区分:責任著者  

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  • Region-specific features of astrocytes against dopaminergic neurotoxin-induced oxidative stress

    Asanuma, M, Okumura-Torigoe, N, Miyazaki, I, Murakami, S, Kitamura, Y, Sendo, T

    14th European Meeting on Glial Cells in Health and Disease Congress Abstract   2019年7月

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    担当区分:筆頭著者, 責任著者  

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  • 妊娠・授乳期のエポキシ樹脂曝露が新生仔マウスに及ぼす行動毒性

    宮崎育子, 菊岡 亮, 磯岡奈未, 禅正和真, 新居 麗, 園部奏生, 船越英丸, 中山恵利香, 進 浩太郎, 山本大地, Kyle Quin, 浅沼幹人

    第46回日本毒性学会学術年会抄録集   2019年6月

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    担当区分:最終著者, 責任著者  

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  • Rotigotine protects dopaminergic neurons via astrocytic serotonin 1A receptors

    Miyazaki, I, Isooka, N, Kikuoka, R, Wada, K, Nakayama, E, Shin, K, Yamamoto, D, Kitamura, Y, Asanuma, M

    第60回日本神経学会学術大会抄録集   2019年5月

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    担当区分:最終著者, 責任著者  

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  • 妊娠・授乳期にエポキシ樹脂曝露した新生仔マウスの脳発達に関する組織学的・行動学的解析

    宮崎育子, 菊岡 亮, 磯岡奈未, 禅正和真, 新居 麗, 園部奏生, 船越英丸, 中山恵利香, 進 浩太郎, 山本大地, Kyle Quin, 浅沼幹人

    第124回日本解剖学会総会抄録集   2019年3月

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    担当区分:最終著者, 責任著者  

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  • Treatment with coffee ingredients protects central and myenteric neurons in parkinsonian model

    Miyazaki, I, Isooka, N, Wada, K, Kikuoka, R, Kitamura, Y, Asanuma, M

    第92回日本薬理学会年会抄録集   2019年3月

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    担当区分:最終著者, 責任著者  

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  • 大学院生が期待するウェットからドライな薬学研究の未来 抗がん剤投与による不安症状の発症機序解明とその治療・予防に向けたアプローチ

    住吉 佑介, 内藤 七海, 中村 優花, 菅 詩歩, 牛尾 聡一郎, 宮崎 育子, 浅沼 幹人, 北村 佳久, 千堂 年昭

    日本薬学会年会要旨集   139年会 ( 1 )   329 - 329   2019年3月

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    記述言語:日本語   出版者・発行元:(公社)日本薬学会  

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  • 外科領域におけるシミュレーション教育の今 実写3D解剖の開発と応用 エコーで見えないものが見えてくる解剖学

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    日本臨床外科学会雑誌   79 ( 増刊 )   284 - 284   2018年10月

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    記述言語:日本語   出版者・発行元:日本臨床外科学会  

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  • ロチゴチンによるアストロサイトのセロトニン1Aレセプターを標的としたドパミン神経保護

    宮崎 育子, 磯岡 奈未, 菊岡 亮, 和田 晃一, 中山 恵利香, 進 浩太郎, 山本 大地, 北村 佳久, 浅沼 幹人

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   12回   117 - 117   2018年7月

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    記述言語:日本語   出版者・発行元:Movement Disorder Society of Japan (MDSJ)  

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  • 医療のさらなる安心・安全を志向する若手研究者のイノベーティブチャレンジ 抗がん剤投与による不安症状発症の病態機序解明 セロトニン神経系の関与

    中村 優花, 住吉 佑介, 内藤 七海, 牛尾 聡一郎, 宮崎 育子, 浅沼 幹人, 北村 佳久, 千堂 年昭

    日本薬学会年会要旨集   138年会 ( 1 )   333 - 333   2018年3月

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    記述言語:日本語   出版者・発行元:(公社)日本薬学会  

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  • 医療のさらなる安心・安全を志向する若手研究者のイノベーティブチャレンジ 抗がん剤投与による不安症状発症の病態機序解明 セロトニン神経系の関与

    中村 優花, 住吉 佑介, 内藤 七海, 牛尾 聡一郎, 宮崎 育子, 浅沼 幹人, 北村 佳久, 千堂 年昭

    日本薬学会年会要旨集   138年会 ( 1 )   333 - 333   2018年3月

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    記述言語:日本語   出版者・発行元:(公社)日本薬学会  

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  • マウスにおける短期持続ストレス誘発性不安関連挙動の行動分析

    TANAKA Ken-ichi, TANAKA Ken-ichi, YAGI Takao, YAGI Takao, ASANUMA Masato

    Journal of Physiological Sciences   68 ( Supplement 1 )   2018年

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  • 農薬ロテノン暴露による腸管神経障害とコーヒー成分による神経保護効果

    宮崎 育子, 磯岡 奈未, 菊岡 亮, 和田 晃一, 北村 佳久, 浅沼 幹人

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   11回   99 - 99   2017年10月

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    記述言語:日本語   出版者・発行元:Movement Disorder Society of Japan (MDSJ)  

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  • 農薬ロテノンによるアストロサイト機能異常がもたらすドパミン神経障害

    宮崎 育子, 菊岡 亮, 磯岡 奈未, 北村 佳久, 浅沼 幹人

    日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集   39回・47回   158 - 158   2017年9月

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    記述言語:日本語   出版者・発行元:日本生物学的精神医学会・日本神経精神薬理学会  

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  • アストロサイトを介したミルタザピンのドパミン神経保護効果に関する検討

    菊岡 亮, 宮崎 育子, 久保田 菜月, 前田 恵実, 香川 大樹, 守山 雅晃, 粂 明日香, 北村 佳久, 浅沼 幹人

    日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集   39回・47回   193 - 193   2017年9月

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    記述言語:日本語   出版者・発行元:日本生物学的精神医学会・日本神経精神薬理学会  

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  • 農薬ロテノンによる非細胞自律性ドパミン神経障害

    宮崎 育子, 村上 真樹, 菊岡 亮, 磯岡 奈未, 北村 佳久, 浅沼 幹人

    The Journal of Toxicological Sciences   42 ( Suppl. )   S321 - S321   2017年6月

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    記述言語:日本語   出版者・発行元:(一社)日本毒性学会  

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  • 革新的創薬・育薬を目指す若手研究者によるトランスレーショナルリサーチの最前線 パーキンソン病モデルマウスにおけるミルタザピンの神経保護効果に関する検討

    菊岡 亮, 宮崎 育子, 浅沼 幹人, 北村 佳久, 千堂 年昭

    日本薬学会年会要旨集   137年会 ( 1 )   284 - 284   2017年3月

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    記述言語:日本語   出版者・発行元:(公社)日本薬学会  

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  • ALSモデルの運動障害および運動神経変性に対するセロトニン1Aアゴニストの抑制効果

    浅沼幹人, 宮崎育子, 村上真樹, 村上真樹, 鳥越菜央, 中野剛志, 菊岡亮, 北村佳久, 千堂年昭

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   10th   68 - 68   2016年10月

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    記述言語:日本語   出版者・発行元:Movement Disorder Society of Japan (MDSJ)  

    J-GLOBAL

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  • 農薬ロテノン暴露によるドパミン神経障害におけるアストロサイトの関与

    宮崎育子, 村上真樹, 村上真樹, 菊岡亮, 磯岡奈未, 北村佳久, 浅沼幹人

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   10th   69 - 69   2016年10月

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    記述言語:日本語   出版者・発行元:Movement Disorder Society of Japan (MDSJ)  

    J-GLOBAL

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  • パーキンソン病モデルマウスにおけるミルタザピンの神経保護効果に関する検討(Neuroprotective effects of mirtazapine in parkinsonian mice)

    菊岡 亮, 宮崎 育子, 久保田 菜月, 前田 恵実, 香川 大樹, 守山 雅晃, 粂 明日香, 村上 真樹, 北村 佳久, 浅沼 幹人

    日本神経精神薬理学会年会プログラム・抄録集   46回   232 - 232   2016年7月

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    記述言語:英語   出版者・発行元:(一社)日本神経精神薬理学会  

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  • 抗うつ薬ミルタザピンのアストロサイトを標的としたドパミン神経保護(Astrocyte-targeted neuroprotection of antidepressant mirtazapine)

    宮崎 育子, 菊岡 亮, 久保田 菜月, 前田 恵実, 香川 大樹, 守山 雅晃, 粂 明日香, 村上 真樹, 北村 佳久, 浅沼 幹人

    日本神経精神薬理学会年会プログラム・抄録集   46回   232 - 232   2016年7月

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    記述言語:英語   出版者・発行元:(一社)日本神経精神薬理学会  

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  • 筋萎縮性側索硬化症モデルにおける運動障害および運動神経変性に対する8-OH-DPATの抑制効果(8-OH-DPAT ameliorates motor dysfunction and motor neuron degeneration in mouse model of amyotrophic lateral sclerosis)

    浅沼 幹人, 宮崎 育子, 村上 真樹, 鳥越 奈央, 中野 剛志, 菊岡 亮, 北村 佳久, 千堂 年昭

    日本神経精神薬理学会年会プログラム・抄録集   46回   232 - 232   2016年7月

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    記述言語:英語   出版者・発行元:(一社)日本神経精神薬理学会  

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  • パーキンソン病モデルマウスにおけるアストロサイトの5‐HT1Aレセプターを標的とした神経保護

    宮崎育子, 宮崎育子, 菊岡亮, 久保田菜月, 前田恵実, 香川大樹, 村上真樹, 村上真樹, 北村佳久, 浅沼幹人, 浅沼幹人

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   9th   67 - 67   2015年10月

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    記述言語:日本語   出版者・発行元:Movement Disorder Society of Japan (MDSJ)  

    J-GLOBAL

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  • ミルタザピンのアストロサイトを標的としたドパミン神経保護効果

    宮崎育子, 菊岡亮, 久保田菜月, 前田恵実, 香川大樹, 村上真樹, 村上真樹, 北村佳久, 浅沼幹人, 浅沼幹人

    日本神経精神薬理学会プログラム・抄録集   45th   185 - 185   2015年9月

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    記述言語:日本語   出版者・発行元:日本生物学的精神医学会・日本神経精神薬理学会  

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  • ALSモデルマウスにおけるセロトニン1Aアゴニストによる神経保護効果の検討

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:ELSEVIER IRELAND LTD  

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  • 精神疾患改善薬スクリーニングモデル動物を用いたローヤルゼリーの薬効評価

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    日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集   19th-39th   247   2009年

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  • Studies on drug dependence (Rept.436): Distinct mechanism of methamphetamine- and methylphenidate-induced dopaminergic neurotoxicity

    Daigo Ikegami, Minoru Narita, Megumi Asato, Yuri Tsurukawa, Keiichi Niikura, Michiko Narita, Masato Asanuma, Taizo Kita, Naoko Kuzumaki, Tsutomu Suzuki

    JOURNAL OF PHARMACOLOGICAL SCIENCES   109   95P - 95P   2009年

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  • Effects of L-theanine on dopaminergic neuronal cells

    Megumi Someya, Mika Takeshima, Maiko Murata, Ikuko Miyazaki, Masato Asanuma, Taizo Kita

    JOURNAL OF PHARMACOLOGICAL SCIENCES   109   277P - 277P   2009年

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  • Early changes in astrocytes after rotenone exposure

    Naotaka Kimoto, Saki Fukuoka, Yuri Kikkawa, Francisco. J. Diaz-Corrales, Ikuko Miyazaki, Masato Asanuma

    JOURNAL OF PHARMACOLOGICAL SCIENCES   109   129P - 129P   2009年

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  • Involvement of dopaminergic system on place aversion induced by naloxone in single-dose morphine-treated rats 査読

    Shigeru Ishida, Kazunori Morohashi, Yuichi Ikuta, Ken-ichiro Fuchi, Yoichi Kawasaki, Masato Asanuma, Hiroaki Araki, Toshiaki Sendo, Yoshihisa Kitamura, Hiromu Kawasaki

    JOURNAL OF PHARMACOLOGICAL SCIENCES   109   221P - 221P   2009年

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  • Involvement of PPAR-gamma in methamphetamine-induced neurotoxicity and protective effect of interferon-gamma 査読

    Saki Fukuoka, Hiroaki Hozumi, Naotaka Kimoto, Yuri Kikkawa, Takeshi Tsuji, Ikuko Miyazaki, Yoshihisa Kitamura, Toshiaki Sendo, Taizo Kita, Masato Asanuma

    JOURNAL OF PHARMACOLOGICAL SCIENCES   109   220P - 220P   2009年

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  • Effects of dopamine transporter expression on treatment of ACTH in rats 査読

    Sayaka Emoto, Yoshihisa Kitamura, Ikuko Miyazaki, Kouhei Kitagawa, Tomoko Nagamachi, Maho Doi, Yui Ishimaru, Masato Asanuma, Toshiaki Sendo

    JOURNAL OF PHARMACOLOGICAL SCIENCES   109   162P - 162P   2009年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:JAPANESE PHARMACOLOGICAL SOC  

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  • メタンフェタミン急性神経毒性に対するインターフェロン‐γの保護効果発現機序に関する検討

    福岡早紀, 浅沼幹人, 宮崎育子, 穂積宏彰, 吉川友理, 木本直孝, 北村佳久, 千堂年昭, 喜多大三

    日本薬理学雑誌   132 ( 3 )   16P   2008年9月

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  • メタンフェタミン神経毒性に対するインターフェロンγの保護効果におけるペルオキシソーム増殖剤活性化受容体γ(PPARγ)の関与(Possible involvement of peroxisome proliferator-activated receptor-γ in protective effects of interferon-γ against methamphetamine-induced neurotoxicity)

    浅沼 幹人, 福岡 早紀, 穂積 宏彰, 宮崎 育子, 北村 佳久, 千堂 年昭, 喜多 大三

    神経化学   47 ( 2-3 )   237 - 237   2008年8月

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    記述言語:英語   出版者・発行元:日本神経化学会  

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  • OJ-186 The Effects of HMGB1 on Ischemia-Reperfusion Injury in the Rat Heart(Myocardial ischemia / reperfusion, basic / clinical(02)(IHD),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

    Oozawa Susumu, Nishibori Masahiro, Mori Shuji, Takahashi Hideo, Kanke Toru, Lie KeYue, Tomono Yasuko, Asanuma Masato, Miyazaki Ikuko, Sano Shunji

    Circulation journal : official journal of the Japanese Circulation Society   72   335 - 335   2008年3月

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    記述言語:英語   出版者・発行元:社団法人日本循環器学会  

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  • Biological roles for neuronal primary cilia

    K. Miyoshi, I. Miyazaki, M. Asanuma

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   62 ( 1 )   S6 - S6   2008年2月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:BLACKWELL PUBLISHING  

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  • Functional analysis of neuronal cilia using pericentrin mutant mice

    Ko Miyoshi, Kyosuke Kasahara, Ikuko Miyazaki, Masato Asanuma

    NEUROSCIENCE RESEARCH   61   S207 - S207   2008年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:ELSEVIER IRELAND LTD  

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  • Effect of baicalin, flavone glucuronide on dopaminergic neuronal cells

    Mika Takeshirna, Yumiko Tanaka, Megurni Someya, Maiko Murata, Ikuko Miyazaki, Masato Asanuma

    JOURNAL OF PHARMACOLOGICAL SCIENCES   106   93P - 93P   2008年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:JAPANESE PHARMACOLOGICAL SOC  

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  • Protective effects of interferon-gamma against methamphetamine-induced neurotoxicity

    Hiroaki Hozumi, Masato Asanuma, Ikuko Miyazaki, Saki Fukuoka, Yuri Kikkawa, Naotaka Kimoto, Yoshihisa Kitamura, Toshiaki Sendou, Taizou Kita, Yutaka Gomita

    JOURNAL OF PHARMACOLOGICAL SCIENCES   106   175P - 175P   2008年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:JAPANESE PHARMACOLOGICAL SOC  

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  • メタンフェタミン急性神経毒性に対するインターフェロン‐γの保護効果発現機序に関する検討

    福岡早紀, 浅沼幹人, 宮崎育子, 穂積宏彰, 吉川友理, 木本直孝, 北村佳久, 千堂年昭, 喜多大三

    日本薬理学会近畿部会プログラム・要旨集   113rd   38   2008年

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    記述言語:日本語  

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  • Effects of chronic ACTH treatment on astrocytes and neurogenesis in adult rat hippocampus 査読

    Tomoko Nagamachi, Ikuko Miyazaki, Sayaka Emoto, Maho Do, Hiromu Kawasaki', Masato Asanuma, Yoshihisa Kitamura, Toshiaki Sendo, Yutaka Gomita

    JOURNAL OF PHARMACOLOGICAL SCIENCES   106   188P - 188P   2008年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:JAPANESE PHARMACOLOGICAL SOC  

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  • Involvement of nucleus accumbens dopaminergic system on place aversion induced by naloxone in single-dose morphine-treated rats 査読

    Shigeru Ishida, Kazunori Morohashi, Yuichi Ikuta, Ken-ichiro Fuchi, Yoichi Kawasaki, Masato Asanuma, Hiroaki Araki, Toshiaki Sendo, Yoshihisa Kitamura, Hiromu Kawasaki

    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN   128   67 - 67   2008年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:PHARMACEUTICAL SOC JAPAN  

    DOI: 10.1248/yakushi.128.395

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  • メタンフェタミン神経毒性に関与する炎症・免疫関連分子の網羅的検索

    穂積 宏彰, 宮崎 育子, 喜多 大三, 北村 佳久, 千堂 年昭, 浅沼 幹人, 五味田 裕

    日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology   27 ( 5 )   294 - 294   2007年11月

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  • ビスフェノールAの培養モノアミン神経系への作用

    竹島 美香, 田中 弓子, 宮崎 育子, 浅沼 幹人, 喜多 大三

    日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology   27 ( 5 )   299 - 299   2007年11月

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  • ドパミンキノン神経毒性におけるグリアでのグルタチオン合成関連分子の変化

    宮崎 育子, 穂積 宏彰, 三好 耕, 浅沼 幹人

    日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology   27 ( 5 )   289 - 289   2007年11月

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  • 違法ドラッグ (いわゆる脱法ドラッグ) の精神依存性および神経毒性 : フェネチルアミン誘導体の評価

    舩田 正彦, 青尾 直也, 浅沼 幹人, 宮崎 育子, 花尻 木倉 瑠理, 合田 幸広, 和田 清

    日本アルコール・薬物医学会雑誌 = Japanese journal of alcohol studies & drug dependence   42 ( 4 )   226 - 227   2007年8月

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  • メチルフェニデートのドパミン神経毒性に対する作用

    日名俊行, 浅沼幹人, 喜多大三, 宮崎育子, 小川紀雄, 北村佳久, 千堂年昭, 五味田裕

    日本薬学会年会要旨集   127th ( 2 )   129   2007年3月

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  • Functional analysis of neuronal primary cilia using pericentrin mutant mice

    Ko Miyoshi, Ikuko Miyazaki, Masato Asanuma

    NEUROSCIENCE RESEARCH   58   S123 - S123   2007年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:ELSEVIER IRELAND LTD  

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  • Neuroprotective effects of four dopamine agonists on 6-hydroxydopamine-induced endoplasmic reticulum stress in the mouse brain

    K. Tanaka, M. Asanuma, N. Ogawa

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   9   S133 - S133   2006年7月

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  • Foxy Methoxy, N,N-diisopropyl-5-methoxytryptamine, a selective inhibitor of serotonin transporter

    C Sogawa, N Sogawa, K Ohyama, J Tagawa, A Fujino, M Asanuma, M Funada, K Onodera, S Kitayama

    JOURNAL OF PHARMACOLOGICAL SCIENCES   100   72P - 72P   2006年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:JAPANESE PHARMACOLOGICAL SOC  

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  • Pericentrin is localized to the base of neuronal primary cilia in the developing cerebral cortex

    Ko Miyoshi, Ikuko Miyazaki, Masato Asanuma

    NEUROSCIENCE RESEARCH   55   S233 - S233   2006年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:ELSEVIER IRELAND LTD  

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  • Aggregation of parkin protein in the centrosome and accumulation of cyclin E/cdk 2 complex in CATH.a cells treated with dopamine

    F. J. Diaz-Corrales, M. Asanuma, I. Miyazaki, K. Miyoshi, N. Ogawa

    MOVEMENT DISORDERS   21   S580 - S581   2006年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:WILEY-LISS  

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  • Specific expression of proapoptotic factor PAG608 on motor neurons in spinal cords of L-DOPA-treated parkinsonian models

    Ikuko Miyazaki, Masako Shimizu, Francisco J. Diaz-Corrales, Maria F. Esraba-Alba, Masato Asanuma

    NEUROSCIENCE RESEARCH   55   S201 - S201   2006年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:ELSEVIER IRELAND LTD  

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  • Neuroprotective effects of dopamine D2 agonists on 6-hydroxydopamine-induced ER stress in the mouse brain

    K Tanaka, H Ogo, K Fukuhara, M Asanuma, N Ogawa

    JOURNAL OF PHARMACOLOGICAL SCIENCES   100   155P - 155P   2006年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:JAPANESE PHARMACOLOGICAL SOC  

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  • キノン体生成のメタンフェタミン急性ドパミン神経毒性発現における関与

    宮崎 育子, 浅沼 幹人, DIAZ-CORRALES Francisco J, 三好 耕, 清水 雅子, 北市 清幸, 小川 紀雄

    日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology   25 ( 6 )   342 - 342   2005年12月

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  • Common anti-apoptotic roles of parkin and alpha-synuclein in human dopaminergic cells (vol 332, pg 233, 2005)

    Y Machida, T Chiba, A Takayanagi, Y Tanaka, M Asanuma, N Ogawa, A Koyama, T Iwatsubo, S Ito, PH Jansen, N Shimizu, K Tanaka, Y Mizuno, N Hattori

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   334 ( 3 )   970 - 970   2005年9月

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    記述言語:英語   出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE  

    DOI: 10.1016/j.bbrc.2005.06.156

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  • Dopamine agonist pergolide prevents levodopa-induced quinoprotein formation in parkinsonian striatum and shows quenching effects on dopamine-semiquinone generated in vitro

    N Ogawa, M Asanuma, L Miyazaki, FJ Diaz-Corrales

    MOVEMENT DISORDERS   20   S69 - S69   2005年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:WILEY-LISS  

    DOI: 10.1097/01.wnf.0000175523.33334.24

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  • β遮断薬による心不全・不整脈治療の基礎と臨床 カルベジロールを中心として β遮断薬と酸化ストレス

    中村 一文, 垣下 幹夫, 草野 研吾, 三浦 綾, 久松 研一, 永瀬 聡, 森田 宏, 斉藤 博則, 江森 哲郎, 浅沼 幹人, 小川 紀雄, 宮崎 正博, 中村 陽一, 松原 広己, 伏見 和郎, 豊國 伸哉, 大江 透

    心電図   24 ( 1 )   15 - 21   2004年1月

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    記述言語:日本語   出版者・発行元:(一社)日本不整脈心電学会  

    拡張型心筋症患者と正常心機能者の心内膜生検組織において,過酸化脂質の代謝産物である4-Hydroxy-2-nonenal(HNE)修飾蛋白質を免疫染色にて検出した.拡張型心筋症患者全例の心筋においてHNE修飾蛋白質が増加していた.その増加は心筋の細胞質に多かった.更にカルベジロール投与を行った後再び調べたところ,心機能の改善と共に,HNE修飾蛋白質が有意に低下していた.以上の検討より,活性酸素による酸化ストレスの発生が不全心筋において増強しており,カルベジロールによるその抑制が心不全治療のターゲットの1つになりうることが示唆された

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