Updated on 2025/03/08

写真a

 
ASANUMA Masato
 
Organization
Faculty of Medicine, Dentistry and Pharmaceutical Sciences Professor
Position
Professor
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Degree

  • Ph.D.(MSci.) ( 1992.3   Okayama University )

Research Interests

  • Neuropharmacology

  • Neurology

  • Neurochemistry

Research Areas

  • Life Science / Neurology

  • Life Science / Neuroscience-general

  • Life Science / Pathophysiologic neuroscience

Education

  • Okayama University   医学研究科   生理系神経化学

    1988.4 - 1992.3

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    Country: Japan

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  • Okayama University   医学部   医学科

    1982.4 - 1988.3

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    Country: Japan

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Research History

  • Faculty of Pharmaceutical Sciences, Tokushima University   Part-time lecturer

    2016.4

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  • Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences   Department of Medical Neurobiology   Professor

    2014.7

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  • National Center of Neurology and Psychiatry   Division of Drug Dependence, National Institute of Mental Health   Part-time researcher

    2007.4 - 2023.3

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  • Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences   Department of Brain Science   Associate Professor

    2001.4 - 2014.6

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  • Okayama University Medical School   Department of Neuroscience, Institute of Molecular and Cellular Medicine   Associate Professor

    2000.10 - 2001.3

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Professional Memberships

  • The Japanese Society of Toxicology

    2017.2

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  • 日本毒性学会生体金属部会(メタルバイオサイエンス研究会)

    2015.2

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  • The Japanese Association of Anatomists

    2012.8

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  • Movement Disorder Society Japan (MDSJ)

    2009.8

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  • The Japanese Pharmacological Society

    2008.1

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Committee Memberships

  • 日本薬理学会   代議員  

    2024.12   

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    Committee type:Academic society

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  • 日本毒性学会   理事  

    2024.7   

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    Committee type:Academic society

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  • 日本神経精神薬理学会   企画研究将来構想委員会 委員  

    2022.11   

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    Committee type:Academic society

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  • Japan Neurological Society   Councilor  

    2021.5   

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    Committee type:Academic society

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  • Movement Disorder Society Japan (MDSJ)   Councilor  

    2020.7   

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Papers

  • Spatiotemporal expression pattern of dyslexia susceptibility 1 candidate 1 (DYX1C1) during rat cerebral cortex development

    Kazumasa Zensho, Ikuko Miyazaki, Aika Isse, Ichika Misawa, Kaori Masai, Makio Oka, Hirokazu Tsukahara, Masato Asanuma

    Pediatric Research   2025.2

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    Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    Abstract

    Background

    Developmental dyslexia (DD) is a common learning disorder with significant consequences for affected individuals. Although several candidate genes, including dyslexia susceptibility 1 candidate 1 (DYX1C1), have been implicated in dyslexia, their role in brain development remains unclear. We aimed to elucidate the spatiotemporal expression patterns of DYX1C1 during cerebral cortex development in rats.

    Methods

    We investigated DYX1C1 expression during cerebral cortex development using rat embryos at various gestational stages (E13.5, 15.5, 17.5 and 20.5) by immunohistochemistry (n = 7 embryos/stage), quantitative real-time PCR (n = 6), and in situ hybridization (n = 11–15).

    Results

    The DYX1C1-positive cells were predominantly located in the outermost layers of the cortical plate, particularly at E15.5. DYX1C1 mRNA expression peaked at E15.5 and subsequently declined. DYX1C1-positive cells did not co-localize with reelin-positive Cajal-Retzius cells, but co-localized with neuronal markers expressed during development, and had shorter primary cilia than DYX1C1-negative cells.

    Conclusions

    Our findings highlight the dynamic expression of DYX1C1 in the developing cerebral cortex of rats, implicating its involvement in neurodevelopmental processes. Further investigation of the functional interactions of DYX1C1, particularly its relationship with reelin and its role in cerebrocortical and hippocampal development, may provide insights into the pathophysiology of dyslexia and neurodevelopmental disorders.

    Impact

    Our study elucidates spatiotemporal expression patterns of endogenous DYX1C1 predominantly in the primitive cortical zone (PCZ), outermost layer of the cortical plate (CP) during cerebral cortex development, particularly peaked at E15.5.

    We revealed the spatial relationship between DYX1C1-positive and reelin-expressing Cajal-Retzius (CR) cells, and co-localize with neuronal markers expressed during cerebral cortex development, indicating its contribution to neuronal migration and cortical layer formation.

    DYX1C1-positive cells mainly in the PCZ possess shorter primary cilia than DYX1C1-negative cells, suggesting the completion of migration.

    DOI: 10.1038/s41390-025-03920-6

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    Other Link: https://www.nature.com/articles/s41390-025-03920-6

  • Editorial: Glial crosstalk in neurological disorders Reviewed

    Ikuko Miyazaki, Masato Asanuma, Francisco Javier Díaz-Corrales

    Frontiers in Cell and Developmental Biology   12   1515052   2024.11

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Frontiers Media SA  

    DOI: 10.3389/fcell.2024.1515052

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  • Neurogenesis impairment with glial activation in the hippocampus-connected regions of intracerebroventricular streptozotocin-injected mice Reviewed

    Kaori Masai, Yuta Nakayama, Kotaro Shin, Chiaki Sugahara, Ikuko Miyazaki, Takao Yasuhara, Isao Date, Masato Asanuma

    Neuroscience Letters   820   137598 - 137598   2024.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.neulet.2023.137598

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  • Behavioural and neurochemical alterations following acute inflammation induced by intraperitoneal and intratracheal injection with lipopolysaccharide in mice. Reviewed

    Yasuhisa Izushi, Shouki Tanaka, Teppei Ueda, Soichiro Ushio, Yuichi Tasaka, Ikuko Miyazaki, Masato Asanuma, Yoshihisa Kitamura

    Naunyn-Schmiedeberg's Archives of Pharmacology   2024

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    Language:English   Publishing type:Research paper (scientific journal)  

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  • Differentially Expressed Nedd4-binding Protein Ndfip1 Protects Neurons Against Methamphetamine-induced Neurotoxicity. Reviewed

    Masato Asanuma, Ikuko Miyazaki, Jean Lud Cadet

    Neurotoxicity Research   2024

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

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Books

  • 生命金属ダイナミクス 生体内における金属の挙動と制御

    浅沼幹人, 宮崎育子( Role: Contributor ,  パーキンソン病と亜鉛結合蛋白. pp304-309)

    エヌ・ティー・エス,東京  2021 

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  • 脳内環境辞典

    浅沼幹人, 宮崎育子( Role: Contributor ,  Nrf2. pp122-123)

    メディカルドウ,大阪  2017 

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  • 脳内環境-維持機構と破綻がもたらす疾患研究

    浅沼幹人, 宮崎育子(アストロサイトの部位特異的プロファイルがもたらす脳内環境と神経保護.pp102-107)

    メディカルドウ,大阪  2014 

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  • Handbook of Free Radicals: Formation, Types and Effects

    Ikuko Miyazaki, Masato Asanuma( Role: Contributor ,  Antioxidative and neuroprotective effects of metallothioneins on dopaminergic neurons. pp557-568)

    Nova Science Publishers, New York  2010 

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  • 腎とフリーラジカル第10集

    浅沼幹人( Role: Contributor ,  酸化ストレスの評価のpitfall─神経科学からの話題.pp32-35)

    東京医学社,東京  2010 

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MISC

  • パーキンソン病におけるメタロチオネインを標的とした神経保護, シンポジウム 1: 多角的アプローチでひも解く生体金属研究の新展開

    宮崎育子, 浅沼幹人

    日本毒性学会生体金属部会メタルバイオサイエンス研究会2024抄録集   2024.10

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    Authorship:Last author   Language:Japanese   Publishing type:Research paper, summary (national, other academic conference)  

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  • ロテノン持続皮下投与によるパーキンソン病モデルマウスに対する迷走神経刺激療法の有効性

    皮居巧嗣, 佐々木達也, 谷本駿, 西条智也, 正井香織, 宮崎育子, 浅沼幹人, 佐々田晋, 安原隆雄, 田中將太

    第83回日本脳神経外科学会総会抄録集   2024.10

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    Language:Japanese   Publishing type:Research paper, summary (national, other academic conference)  

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  • Pulmonary inflammation induced by intratracheal lipopolysaccharide injection causes anxiety-like behavior in mice.

    Izushi, Y., Tanaka, S., Ueda, T., Ago, T., Ushio, S., Tasaka, Y., Miyazaki, I., Asanuma, M., Kitamura, Y.

    Neuroscience 2024, Abstract   2024.10

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    Language:English   Publishing type:Research paper, summary (international conference)  

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  • 危険ドラッグの神経細胞毒性発現の蓋然性スクリーニング:フェネチルアミン系薬物を中心に. シンポジウム: 危険ドラッグの乱用・流通の現状と有害作用評価研究の最前線

    浅沼幹人, 宮崎育子

    2024年度薬物依存関連学会合同学術総会抄録集   2024.9

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publishing type:Research paper, summary (national, other academic conference)  

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  • パーキンソン病における神経グリア連関. シンポジウム: 神経・グリアクロストークが織りなす神経病態/Glial Crosstalk in Neurological Disorder

    宮崎育子, 浅沼幹人

    第51回日本毒性学会学術年会抄録集   2024.7

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    Authorship:Last author   Language:Japanese   Publishing type:Research paper, summary (national, other academic conference)  

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Presentations

  • 妊娠・授乳期マウスのエポキシ樹脂BADGE曝露による産仔の行動異常

    正井加織, 富本佳奈, Yan Geng, 後藤顕次, 畠山昂太郎, 宮﨑育子, 浅沼幹人

    第42回創薬・薬理フォーラム岡山  2024.12.21 

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    Event date: 2024.12.21

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • パーキンソン病におけるメタロチオネインを標的とした神経保護, シンポジウム 1: 多角的アプローチでひも解く生体金属研究の新展開.

    宮崎育子, 浅沼幹人

    日本毒性学会生体金属部会メタルバイオサイエンス研究会2024  2024.10.17 

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    Event date: 2024.10.17 - 2024.10.18

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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  • ロテノン持続皮下投与によるパーキンソン病モデルマウスに対する迷走神経刺激療法の有効性.

    皮居巧嗣, 佐々木達也, 谷本駿, 西条智也, 正井香織, 宮崎育子, 浅沼幹人, 佐々田晋, 安原隆雄, 田中將太

    第83回日本脳神経外科学会総会  2024.10.16 

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    Event date: 2024.10.16 - 2024.10.18

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 危険ドラッグの神経細胞毒性発現の蓋然性スクリーニング:フェネチルアミン系薬物を中心に. シンポジウム: 危険ドラッグの乱用・流通の現状と有害作用評価研究の最前線

    浅沼幹人, 宮崎育子

    2024年度薬物依存関連学会合同学術総会  2024.9.21 

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    Event date: 2024.9.19 - 2024.9.21

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

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  • Contribution of glial cells to the vulnerability of the medial septum cholinergic neurons to oxidative stress.

    Masai, K. Miyazaki, I, Asanuma, M

    2024.7.25 

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    Event date: 2024.7.24 - 2024.7.27

    Language:English   Presentation type:Poster presentation  

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Awards

  • 2022年度日本毒性学会生体金属部会 部会賞

    2022.10   日本毒性学会生体金属部会   神経保護修飾薬の創薬標的となりうるグリア細胞アストロサイトのメタロチオネイン

    浅沼幹人

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  • 第10回パーキンソン病・運動障害疾患コングレス 優秀賞

    2016.10   日本パーキンソン病・運動障害疾患学会   ALSモデルの運動障害および運動神経変性に対するセロトニン1Aアゴニストの抑制効果

    浅沼幹人

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    Country:Japan

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  • 第5回パーキンソン病・運動障害疾患コングレス 優秀ポスター賞

    2011.10   日本パーキンソン病・運動障害疾患学会   ロテノン曝露の腸管神経叢における神経およびグリア細胞への影響

    浅沼幹人

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  • Juhn and Mary Wada Prize, The Japan Epilepsy Society

    1996.10  

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    Country:Japan

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  • 1991年度岡山医学会 新見賞

    1992.2   岡山医学会   Alterations of somatostatin and its modulation by levodopa in MPTP-treated mice brain

    浅沼幹人

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Research Projects

  • 腸管粘膜バリアの破綻に着目した末梢先行型パーキンソン病の神経変性機構の解明

    Grant number:24K10620  2024.04 - 2027.03

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    浅沼 幹人, 宮崎 育子

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    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct expense: \3600000 、 Indirect expense:\1080000 )

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  • パーキンソン病での中枢・腸管神経障害に対する緑茶成分テアニンの消化管神経環境修飾による神経保護効果

    2023.08 - 2024.07

    本庄八郎記念お茶財団  2023年度助成金 

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  • 食品容器から溶出するエポキシ樹脂への妊娠期曝露による産仔自閉症様早期脳発達の機序

    2023.07 - 2024.06

    三島海雲記念財団  2023年度学術研究奨励金(自然科学部門/個人研究奨励金) 

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  • Inhibition of cell-to-cell propagation of alpha-synuclein aggregation by glial cells and its involvement in neuropathology in Parkinson's disease.

    Grant number:23K06928  2023.04 - 2026.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    宮崎 育子, 浅沼 幹人

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    Authorship:Coinvestigator(s) 

    Grant amount:\4550000 ( Direct expense: \3500000 、 Indirect expense:\1050000 )

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  • Involvement of astrocytes on mental function due to inflammation-induced GABAergic nerve system

    Grant number:22K06714  2022.04 - 2025.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    北村 佳久, 浅沼 幹人

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    Grant amount:\4030000 ( Direct expense: \3100000 、 Indirect expense:\930000 )

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Class subject in charge

  • Primary Anatomy (2024academic year) special  - その他

  • Human Anatomy (2024academic year) Concentration  - その他

  • Medical Tutorial (2024academic year) 1st semester  - 火2~3

  • Mystery of Life 1 (2024academic year) Third semester  - 木1~2

  • Neuroanatomy (2024academic year) special  - その他

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