記述言語：英語  

OBJECTIVE: This report describes the case of a male patient with a complete unilateral cleft lip and palate who presented with midface deficiency and an anteroposteriorly constricted maxilla. DESIGN: Case report Interventions: Correction involved anterior distraction of the segmented maxilla. RESULTS: The present case demonstrates that elongation of the maxilla with anterior distraction is an effective way to develop a proper dental arch, correct anterior and posterior crowding, and improve a midface deficiency.

DOI： 10.1177/1055665618821831

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：英語  

OBJECTIVES: To evaluate the effects of maxillary anterior segmental distraction osteogenesis (MASDO) in patients with cleft lip and palate (CLP) and to identify risk factors for increased relapse. DESIGN: A retrospective study. PATIENTS: Thirty-one Japanese patients with CLP who underwent MASDO were eligible for study inclusion. MAIN OUTCOME MEASURES: We evaluated lateral cephalograms obtained before (T1), at 3 months (T2), and at 1 year (T3) after MASDO, and measured changes from T1 to T2 (δT1T2), from T2 to T3 (δT2T3), and from T1 to T3 (δT1T3). We also evaluated the risk factors associated with an increased relapse. RESULTS: Overall (δT1T3), MASDO improved retrusion of the maxilla. We measured a significant advancement (6.1 mm) of the anterior maxillary segment in δT1T2 (A-McNamara classification) and increases in the overjet and the SNA, ANB, and nasolabial angles. However, skeletal relapse was evident in δT2T3, and the median percentage of relapse was 10%. To explore the risk factors, we subdivided patients with a δT1T2 of >5 mm into 2 groups based on the percentage of relapse (>15% vs ≤15%). There were significant differences between these groups in the vertical positions of the anterior nasal spine and point A, and the angle formed by the SN and palatal planes (SNPP), suggestive of intraoperative counterclockwise rotation of the maxilla. CONCLUSIONS: MASDO is effective for correcting midfacial deficiencies, but counterclockwise rotation of the maxilla during surgery may cause relapse.

DOI： 10.1177/1055665618758692

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：ELSEVIER SCIENCE BV  

Odontomas are generally encountered in permanent dentition and rarely seen in primary dentition. These lesions are regarded as essentially benign, though they often cause disturbances in eruption of the associated tooth. We present clinical findings and management of 3 cases of odontomas that occurred in primary dentition, including a 3-year-old girl referred for examination of an unerupted left upper primary canine, a 6-year-old boy with an unerupted left lower second primary molar, and a 5-year-old girl who was presented with an unerupted right upper second primary molar. In all cases, periapical and panoramic radiography revealed a radio-opaque mass surrounded by a narrow radiolucent space located above the crown of the unerupted tooth. Each was diagnosed as a compound odontoma interfering with eruption of a primary tooth and surgical removal was performed under general anesthesia for all patients, with the final diagnosis based on histological findings. Following surgery, the primary canine in Case 1 spontaneously erupted, while a space maintenance appliance was applied in Case 2 and 3. It is important to recognize that an odontoma can appear in primary dentition, though the incidence is quite low. Early detection and removal of an odontoma associated with an impacted primary tooth is necessary for optimal dentition. (C) 2017 Published by Elsevier Ltd on behalf of Japanese Society of Pediatric Dentistry.

DOI： 10.1016/j.pdj.2017.10.001

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DOI： 10.1016/j.jds.2017.03.007

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記述言語：日本語   出版者・発行元：(公社)日本口腔外科学会  

症例は21歳女性で、13年前に左側頬部の腫瘤を自覚したが確定診断には至らなかった。左側頬部に鈍痛を覚えるようになり、腫瘤の増大を認めた。左側頬粘膜は表面正常で、触診にて咬筋相当部に可動性で軽度の圧痛を伴う30mm大の骨様硬の病変を触知した。単純CT画像では、左側狡筋は右側と比較し腫大し、内部に長径22mm大、外形不整な高吸収域を認めた。病変内部に長径3〜6mm大の複数の類円形石灰物を認めた。造影CT画像では、高吸収域に不均一な造影効果を認め、造影性の高い領域では血管腔と同程度の高い造影性を示した。腫瘤内石灰化物の多くは内部に核を有し、層板状構造に近い性状であった。MRI所見では、病変内部はT1強調画像では低信号から筋と同程度の不均一な信号強度、T2強調画像では低信号から高信号の不均一な信号強度を呈し、石灰化物に相当する部分はほぼ無信号を呈した。全身麻酔下で口腔内より腫瘤の摘出術を施行した。現在、術後3年経過しているが、再発はなく経過良好である。摘出標本の病理組織学的診断は静脈石を伴った静脈奇形であった。

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その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2017&ichushi_jid=J01073&link_issn=&doc_id=20171130350014&doc_link_id=10.5794%2Fjjoms.63.593&url=https%3A%2F%2Fdoi.org%2F10.5794%2Fjjoms.63.593&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：ALLIANCE COMMUNICATIONS GROUP DIVISION ALLEN PRESS  

This report describes a case of successful orthodontic treatment using maxillary anterior segmental distraction osteogenesis with an internal maxillary distractor and bilateral sagittal split ramus osteotomy in a girl with cleft lip and palate. A 16-year-old girl with unilateral cleft lip and palate exhibited midface retrusion because of growth inhibition of the maxillary complex and mandibular excess. After the presurgical orthodontic treatment, 6.0-mm advancement of the maxillary anterior segment and 4.0-mm set back of the mandible were performed. After a retention period, the patient's midface convexity was greatly improved and the velopharyngeal competence was preserved without relapse.

DOI： 10.1597/14-326

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記述言語：日本語   出版者・発行元：社団法人 日本口腔外科学会  

<p>This report describes a case of venous malformation associated with multiple phleboliths in the masseter muscle. A 21-year-old woman presented with swelling of the left cheek. Computed tomography and magnetic resonance imaging suggested the presence of phleboliths in the venous malformation in the left masseter muscle. The venous malformation with the phleboliths was extirpated through an intraoral approach with the patient under general anesthesia. The postoperative course was uneventful, and the patient was asymptomatic with no signs of recurrence during 3 years of follow-up.</p>

DOI： 10.5794/jjoms.63.593

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その他リンク： http://search.jamas.or.jp/link/ui/2018061904

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SPANDIDOS PUBL LTD  

Odontogenic tumors and cysts, arising in the jawbones, grow by resorption and destruction of the jawbones. However, mechanisms underlying bone resorption by odontogenic tumors/cysts remain unclear. Odontogenic tumors/cysts comprise odontogenic epithelial cells and stromal fibroblasts, which originate from the developing tooth germ. It has been demonstrated that odontogenic epithelial cells of the developing tooth germ induce osteoclastogenesis to prevent the tooth germ from invading the developing bone to maintain its structure in developing bones. Thus, we hypothesized that odontogenic epithelial cells of odontogenic tumors/cysts induce osteoclast formation, which plays potential roles in tumor/cyst outgrowth into the jawbone. The purpose of this study was to examine osteoclastogenesis by cytokines, focusing on transforming growth factor-beta (TGF-beta), produced by odontogenic epithelial cells. We observed two pathways for receptor activator of NF-kappa B ligand (RANKL) induction by keratocystic odontogenic tumor fluid: the cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) pathway through interleukin-1 alpha (IL-1 alpha) signaling and non-COX-2/PGE2 pathway through TGF-beta receptor signaling. TGF-beta 1 and IL-1 alpha produced by odontogenic tumors/cysts induced osteoclastogenesis directly in the osteoclast precursor cells and indirectly via increased RANKL induction in the stroma.

DOI： 10.3892/ijo.2016.3548

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：ALLIANCE COMMUNICATIONS GROUP DIVISION ALLEN PRESS  

The present report describes a male patient with a unilateral cleft lip and palate who presented with midfacial anteroposterior and transverse deficiency. Correction involved a two-stage surgical-orthodontic approach: asymmetric anterior distraction of the segmented maxilla followed by two-jaw surgery (LeFort I and bilateral sagittal splitting ramus osteotomies). The present case demonstrates that the asymmetric elongation of the maxilla with anterior distraction is an effective way to correct a transversely distorted alveolar form and midfacial anteroposterior deficiency. Furthermore, successful tooth movement was demonstrated in the new bone created by distraction.

DOI： 10.1597/14-322

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DOI： 10.1597/14-322

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DOI： 10.1016/j.ajoms.2015.07.001

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記述言語：日本語   出版者・発行元：(一社)医療の質・安全学会  

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掲載種別：研究論文（学術雑誌）  

Objective: The antilingular prominence (AP) is a well-known landmark used during planning of intraoral vertical ramus osteotomy (IVRO) in order to prevent inferior alveolar nerve (IAN) injury, but the location of this landmark is not always clear. In this study, we analyzed the anatomical relationship between the mandibular foramen (MF) and the lateral surface shape of the mandibular ramus for use during IVRO. Patients and methods: We retrospectively analyzed 276 mandibular halves in 67 patients with mandibular deformity and 71 patients without deformity imaged at our department from April 2003 to March 2014. We defined 17 points on the mandibular ramus, and examined the anatomical relationships using multi-planar reconstruction (MPR) images and three-dimensional computed tomography (3DCT) created from preoperative CT data. Results: The prevalence of the AP was 57.6% (159/276) of all cases. The MF was located inferior to the AP in all cases; it was posterior to the AP in 50.3% (80/159) of cases and the sigmoid notch (SN) in 24.6% (68/276) of cases. The minimum horizontal distance between the mandibular posterior ramus border and the MF was 9.28. mm in all cases. Conclusion: The AP cannot always serve as a reference point to prevent IAN damage during IVRO. The osteotomy incision should be placed within 9. mm of the posterior mandibular ramus border in order to prevent intraoperative IAN damage. However, preoperative review of planned osteotomy incisions is necessary in every case.

DOI： 10.1016/j.ajoms.2014.11.007

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：ELSEVIER SCIENCE INC  

Objective: The antilingular prominence (AP) is a well-known landmark used during planning of intraoral vertical ramus osteotomy (IVRO) in order to prevent inferior alveolar nerve (IAN) injury, but the location of this landmark is not always clear. In this study, we analyzed the anatomical relationship between the mandibular foramen (MF) and the lateral surface shape of the mandibular ramus for use during IVRO.Patients and methods: We retrospectively analyzed 276 mandibular halves in 67 patients with mandibular deformity and 71 patients without deformity imaged at our department from April 2003 to March 2014. We defined 17 points on the mandibular ramus, and examined the anatomical relationships using multiplanar reconstruction (MPR) images and three-dimensional computed tomography (3DCT) created from preoperative CT data.Results: The prevalence of the AP was 57.6% (159/276) of all cases. The MF was located inferior to the AP in all cases; it was posterior to the AP in 50.3% (80/159) of cases and the sigmoid notch (SN) in 24.6% (68/276) of cases. The minimum horizontal distance between the mandibular posterior ramus border and the MF was 9.28 mm in all cases.Conclusion: The AP cannot always serve as a reference point to prevent IAN damage during IVRO. The osteotomy incision should be placed within 9 mm of the posterior mandibular ramus border in order to prevent intraoperative IAN damage. However, preoperative review of planned osteotomy incisions is necessary in every case. (c) 2014 Asian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAMI. Published by Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.ajoms.2014.11.007

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：ALLIANCE COMMUNICATIONS GROUP DIVISION ALLEN PRESS  

This case report presents the management of a female patient with unilateral cleft lip and palate presenting with skeletal Class III malocclusion and a narrow upper dental arch with a midline deviation. The treatment plan involved asymmetric transverse distraction osteogenesis of the maxilla to make the upper dental midline coincident with the facial midline. After the treatment, a good facial profile and a close intercuspation of teeth were achieved. Occlusion remained stable with normal overjet and overbite after 2-year retention.

DOI： 10.1597/13-278

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DOI： 10.1597/13-278

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：OKAYAMA UNIV MED SCHOOL  

This article reports the case of a 44-year-old male with skeletal Class III, Angle Class III malocclusion and unilateral crossbite with concerns about obstructive sleep apnea syndrome (OSAS), esthetics and functional problems. To correct the skeletal deformities, the maxilla was anteriorly repositioned by employing LeFort I osteotomy following pre-surgical orthodontic treatment, because a mandibular setback might induce disordered breathing and cause OSAS. After active treatment for 13 months, satisfactory occlusion was achieved and an acceptable facial and oral profile was obtained. In addition, the apnea hypopnea index (AHI) decreased from 18.8 preoperatively to 10.6 postoperatively. Furthermore, after a follow-up period of 7 months, the AHI again significantly decreased from 10.6 to 6.2. In conclusion, surgical advancement of the maxilla using LeFort I osteotomy has proven to be useful in patients with this kind of skeletal malocclusion, while preventing a worsening of the OSAS.

DOI： 10.18926/AMO/53525

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その他リンク： http://orcid.org/0000-0002-4419-9643

記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

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記述言語：日本語   出版者・発行元：岡山歯学会  

口腔癌検診研修会基礎コースを修了した歯科医師を対象に、研修会終了後にアンケート調査を行った。2013年に行われた3回の研修会の研修者の合計は46人(3人が2回研修)であった。臨床経験年数は10〜42年(平均23.6年、中央値25年)に比較的長い研修者が多かった。口腔癌症例経験ありは70%に認められ、経験症例数は1〜3例が多かった。口腔癌症例経験者の中で癌の疑いがあると診断して専門機関に紹介した症例が93%と大部分を占めた。しかし、その中で早期癌を診断できた症例は45%に過ぎず、初診時に進行していた症例も46例に認められた。また、紹介が少し遅くなった症例が9%認められたが患者が専門機関をなかなか受診してくれなかった例も1例あった。癌の部位は舌が最も多く41%認められ、下顎歯肉32%、口底13%と続いた。研修会の時間・レベルは概ね適切で、講義・実習・テキストもためになり、今後の臨床に役立つとの回答が得られた。再研修の必要性は91%と多かったが、アドバンスコースの希望者は69%に留まり、ベーシックコースの希望者も22%認められた。また、再研修までの期間は1年の35%を前後にばらつきが認められた。研修者はより実践的に役立つ研修内容を希望していた。

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記述言語：日本語   出版者・発行元：(公社)日本矯正歯科学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：WILEY-BLACKWELL  

In recent years, artificial biological materials have been commonly used for the treatment of bone tissue defects caused by trauma, tumors, or surgical stress. Although tricalcium phosphate (TCP) is a promising absorbent bone tissue reconstruction biomaterial, it has been reported that its biocompatibility and osteoconductivity depend on its preparation method and sintering temperature. In addition, although it is thought that the microenvironment produced by the extracellular matrix plays an important role in cell growth and differentiation, there have been few studies on how the geometric structure of artificial biological materials affects cells. In the present study, a new honeycomb TCP scaffold containing through-holes with diameters of 300 mm has been developed. The influence of the sintering temperature on the crystal structure and material properties of the honeycomb TCP scaffold was investigated using scanning electron microscopy and X-ray diffraction. Its biocompatibility and osteoconductivity were also evaluated by implantation into experimental animals. It was found that a beta-TCP scaffold sintered at 1200 degrees C exhibited high biocompatibility and osteoconductivity, and when it was loaded with BMP-2, it exhibited both osteoconductivity and osteoinductivity, promoting rapid bone formation in both ectopic and orthotopic areas. It is thus a highly promising bone reconstruction material that is expected to find clinical applications. (C) 2013 Wiley Periodicals, Inc.

DOI： 10.1002/jbm.a.34966

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：日本語   出版者・発行元：岡山歯学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：CHURCHILL LIVINGSTONE  

Objectives: The purpose of this study was to explore the voice characteristics of patients with mandibular prognathism, and to investigate the effects of mandibular setback surgery on these characteristics using nonlinear dynamics and conventional acoustic analyses.
Materials and methods: Sixteen patients (8 males and 8 females) who had skeletal 3, class III malocclusion without cleft palate, and who underwent a bilateral sagittal split ramus osteotomy (BSSRO), were enrolled. As controls, 50 healthy adults (25 males and 25 females) were enrolled. The mean first LEs (mLE1) computed for each one-second interval, and the fundamental frequency (F0) and frequencies of the first and second formant (F1, F2) were calculated for each Japanese vowel.
Results and conclusions: The mLE1s for /u/ in males, and /o/ in females and the F2s for /i/ and /u/ in males, changed significantly after BSSRO. Class III voice characteristics were observed in the mLE1s for /i/ in both males and females, in the F0 for /a/, /i/, /u/ and /o/ in females, and in the F1 and F2 for /a/ in males, and the F1 for /u/ and the F2 for /i/ in females. Most of these characteristics were preserved after BSSRO. (C) 2013 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.jcms.2012.01.021

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記述言語：日本語   出版者・発行元：(一社)医療の質・安全学会  

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記述言語：日本語   出版者・発行元：(公社)日本矯正歯科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：英語  

DOI： 10.1007/s00223-012-9685-3

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MOSBY-ELSEVIER  

Delayed tooth eruption can affect the accuracy of orthodontic diagnosis and treatment planning and could delay overall treatment. A girl, aged 7 years 4 months, who had unilateral delayed eruption of several teeth was successfully treated. The evaluation of delayed tooth eruption should be considered by the orthodontist because the role of these teeth can affect the overall treatment of malocclusion. In patients with delayed tooth eruption, careful and accurate diagnosis and treatment planning will allow the orthodontist to start treatment at the proper stage and might reduce the overall orthodontic treatment time. (Am J Orthod Dentofacial Orthop 2013;143:134-9)

DOI： 10.1016/j.ajodo.2011.11.024

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記述言語：日本語   出版者・発行元：岡山歯学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare malignant odontogenic tumor arising from odontogenic epithelial remnants within the jawbones. PIOSCC is histopathologically divided into 3 types: solid-type carcinoma, carcinoma derived from a keratocystic odontogenic tumor, and carcinoma derived from an odontogenic cyst. In this article, we report a case of solid-type PIOSCC involving reactive bone formation in the mandible in a 60-year-old female patient together with its histopathological and imaging findings. © 2012 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.oooo.2012.05.019

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記述言語：日本語   出版者・発行元：(一社)医療の質・安全学会  

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記述言語：日本語   出版者・発行元：(公社)日本矯正歯科学会  

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記述言語：日本語   出版者・発行元：(公社)日本矯正歯科学会  

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記述言語：日本語   出版者・発行元：(公社)日本歯科医師会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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DOI： 10.1016/j.jcms.2011.04.019

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DOI： 10.1007/s10735-011-9385-8

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記述言語：日本語   出版者・発行元：Japanese Society of Oral and Maxillofacial Surgeons  

DOI： 10.5794/jjoms.58.501

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記述言語：日本語   出版者・発行元：Japanese Society of Oral and Maxillofacial Surgeons  

Maxillary anterior segmental distraction osteogenesis (MASDO) is a rather new surgical orthodontic treatment to produce an ideal maxillary dental arch form in patients with cleft lip and palate. Different from total maxillary advancement by DO, this surgical procedure can solves the problems in the small and retruded maxilla without the risk of deterioration of velopharyngeal function, because the distracted segment is only made at the anterior part of the maxillary bone.<br>To advance the anterior segment in only a single vector, a single palatal bone-borne distractor or toothborne distractor is effective, but two hybrid type distractors on each side of alveolar process can produce some rotational movements of anterior segment by controlling advancement amount in each side. Therefore, this procedure solves not only the size of maxillary arch but also the shape of deformed dental arch.<br>As bone height and width at distracted space on alveolar process is enough for fuature alignments of crowding teeth or anterior movement of molars, this treatment is an effective pre-orthodontic surgical treatment for solving discrepancy of maxillary dental arch.

DOI： 10.5794/jjoms.58.562

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

The purpose of this study was to determine the accuracy of a new high resolution digital camerabased three-dimensional system called Di3D by comparing with traditional direct anthropometry using digital calipers. The study sample consisted of 20 young adults, 10 male and 10 female. Facial soft tissue landmarks were identified and five linear distances were measured between the landmarks for each subject using the two methods
Di3D camera system and a digital caliper. No statistically significant differences (P &gt
0.05) were found for all five facial soft tissue distances measured by the Di3D camera system and the digital caliper. The magnitude of differences was very small (mean = 0.73 mm). Good congruence was observed between the means derived from the Di3D system and the digital caliper. The overall mean differences of the five measurements with these two methods were small enough to be clinically insignificant. The results show that both methods are concordant and one method can replace the other in clinical use. © 2012 The Hard Tissue Biology Network Association Printed in Japan, All rights reserved.

DOI： 10.2485/jhtb.21.87

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：CHURCHILL LIVINGSTONE  

DOI： 10.1016/j.bjoms.2010.09.004

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：ELSEVIER SCIENCE BV  

Identification and characterization of local molecules directing the differentiation of chondrocytes to either transient or permanent cartilage are major issues in cartilage biology. Here, we found CCN family protein 3 (CCN3) was abundantly produced in rat developing epiphyseal cartilage. Evaluations in vitro showed that CCN3 repressed epiphyseal chondrocyte proliferation, while promoting matrix production in multiple assays performed. Furthermore, CCN3 enhanced the articular chondrocytic phenotype; whereas it repressed the one representing endochondral ossification. Additionally, the phenotype of growth plate chondrocytes and chondrogenic progenitors also appeared to be affected by CCN3 in a similar manner. These findings suggest a significant role of CCN3 in inducing chondrocytes to articular ones during joint formation. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

DOI： 10.1016/j.febslet.2011.08.024

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS  

This study was designed to evaluate detailed philtral morphology involving sex and racial differences and to clarify the objective parameters related to subjective judgments regarding the clarity of the philtrum. Fifty-five Japanese and 20 Mexican normal subjects aged 24 to 40 years were recruited, and three-dimensional facial data were acquired using a noncontacting optical surface scanner. The visual classification of the philtral column morphology in Japanese adults using facial photographs revealed that the predominant philtral column shape was different by sex. The three-dimensional anthropometric data showed significant sex differences, which were reflected in the more pronounced visual impression of the philtrum in men. A comparative study between Japanese and Mexican women also revealed certain racial differences. Furthermore, both the philtral depth and central angle of Cupid's bow were extracted as explanatory variables related to the subjective judgments for the clarity of the philtrum. These results suggest that the comprehensive evaluation of philtral morphologic features by three-dimensional analysis is a useful means of identifying the ideal parameters in philtral construction in cleft surgery.

DOI： 10.1097/SCS.0b013e31822e5ebf

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Chondrocytes forming articular cartilage are embedded in a vast amount of extracellular matrix having physical stiffness and elasticity, properties that support the mechanical load from bones and enable the flexible movement of synovial joints. Unlike chondrocytes that conduct the growth of long bones by forming the growth plate, articular chondrocytes show suppressed cell proliferation, unless these cells are exposed to pathological conditions such as mechanical overload. In the present study, we found that one of the members of the CCN family, CCN3, was significantly expressed in chondrocytes isolated from the epiphyseal head in developing rat synovial joints. Evaluation of the effect of recombinant CCN3 on those chondrocytes revealed that CCN3 promoted proteoglycan synthesis, whereas this factor repressed the proliferation of the same cells. These results suggest a critical role for CCN3 in the regulation of the biological properties of articular chondrocytes. © The International CCN Society 2011.

DOI： 10.1007/s12079-011-0135-1

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：日本口腔外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

This study involved a histologic, enzyme histologic, immunohistologic, and three-dimensional microstructure evaluating the extent of osteogenesis and repair in the human alveolar extraction socket achievable with an artificial bone substitute. After tooth extraction in 7 patients, extraction sockets were filled with Mastergraft (15% hydroxyapatite, 85% β-tricalcium phosphate complex). Radiomicrographs and histologic examinations were performed on samples obtained during dental implant placement procedure. On micro-computed tomography, new bone was observed in all collected samples, and osteogenesis was observed to have taken place around the artificial bone substitute. Histologically, active osteogenesis was found throughout the region observed. Addition of new bone around the Mastergraft was observed, and osteoblast-like cells were present. Cells that had partially invaded the artificial bone included tartrate-resistant acid phosphate-positive and CD34-positive cells. These findings indicate that the Mastergraft artificial bone induced osteogenesis in the jawbone and seemed effective for repairing bone defects. Copyright © 2011 by Mutaz B. Habal, MD.

DOI： 10.1097/SCS.0b013e318208bacf

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Journal of Clinical Pediatric Dentistry  

Objective: The purpose of this study was to explore the 3-dimensional (3D) accuracy of magnetic resonance imaging (MRI) on cone-beam computed tomography (CBCT) images after the registration of MRI images on CBCT images. Materials and Methods: Three Japanese adult females volunteered for this study. To transform digital imaging and communication in medicine (DICOM) data derived from MRI and CBCT images into polygon data, five software programs were used. CBCT and MRI images were obtained within one week, and both were registered by the iterative closest point (ICP) method. To assess the accuracy of the composite MRI-CBCT, the measurement errors of the MRI-CBCT were verified. Measurement values were compared using frontal and cephalometric soft-tissue landmarks. Differences were analyzed using the non-parametric Mann-Whitney U test. Results: There were no significant linear measurement errors (P 0.05) when the images were measured from the superimposed MRI-CBCT images. Conclusion: The MRI images attained from MRI-CBCT registration showed accurate 3D linear measurements.

DOI： 10.17796/jcpd.36.2.r7853hp574045414

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Springer-Verlag Tokyo  

In patients in whom a tracheal tube cannot be inserted through the nostrils due to multiple facial trauma or hypoplasty of the nose, submental orotracheal intubation (SOI) is performed to avoid tracheostomy. We report a new modification for SOI to minimize the risk of apnea. A 20-year-old man was scheduled for sagittal split ramus osteotomy. As the patient had severe hypoplasia of the nose, SOI was planned. Following orotracheal intubation with a spiral tube (first tube), a submental tunnel was surgically created. A second tube that had been confirmed, in advance, to snugly fit into the proximal end of the first tube was passed into the submental tunnel via a polypropylene cylinder and connected between the first tube and the breathing circuit. After careful withdrawal of the second tube through the submental tunnel, the first tube was directly connected to the breathing circuit after removal of the second tube. Although this technique requires additional time, apnea time is minimal even in patients in whom withdrawal of the tracheal tube through the submental tunnel takes time, because the second tube forms a link between the first tube and the breathing circuit, making it possible to ventilate the patient throughout the procedure. © Japanese Society of Anesthesiologists 2011.

DOI： 10.1007/s00540-011-1204-6

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：OKAYAMA UNIV MED SCHOOL  

The term atypical lipomatous tumor (ALT) is synonymous with well-differentiated liposarcoma (WDL). This tumor occurs very rarely in the tongue. Thus, it is difficult to predict its prognosis. Although recurrence of ALT/WDL is thought to be unlikely after complete excision, long-term follow-up is necessary when considering the pathologic conditions of this tumor at other sites. Here, we report a case of an ALT of the tongue, with a review of the literature. A 68-year-old man was referred to our hospital because of a tumor on the left side of his tongue. Upon palpation, the tumor was 12mm in diameter, circumscribed, elastic and hard, well demarcated, movable, and painless. We diagnosed the lesion as a lipoma and extirpated the tumor under local anesthesia. Because the specimen was histopathologically diagnosed as an ALT, as a precaution, we excised an additional 5mm from the area surrounding the original tumor under general anesthesia. Three years after the operation, the tongue demonstrated good healing without paresthesia or dysfunction, and to date there has been no evidence of recurrence.

DOI： 10.18926/AMO/40134

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Herein, we report a very rare case of pilomatricoma in the perioral region. A 27-year old Japanese female was referred to our clinic with a subcutaneous tumor in the angle of the left side of the mouth. The tumor was observed as a subcutaneous well-circumscribed and bony hard mass, without any changes of the skin surface, while a soft radiographic examination revealed a weak calcifying rounded mass. The tumor was extirpated using an intraoral approach, because of patient request. During the operation, the tumor was found to be partly attached to the surface skin, though easily removed from the surrounding tissue. The tumor was a rounded calcifying mass, 13. mm in diameter, and histologically diagnosed as a pilomatricoma. © 2010 Asian Association of Oral and Maxillofacial Surgeons.

DOI： 10.1016/j.ajoms.2009.05.003

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記述言語：日本語   出版者・発行元：(NPO)日本顎変形症学会  

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

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記述言語：日本語   出版者・発行元：(公社)日本口腔外科学会  

症例は45歳女性で、1年前より左側上顎臼歯部に時折違和感を自覚していたが放置した。歯科治療で撮影されたパノラマX線で左側上顎洞内のX線不透過像を指摘された。顔貌は左右対称で、左側上顎眼窩下部に圧痛等の異常所見は認めなかった。左側上顎歯肉部に膨隆や腫脹、発赤等の異常所見を認めなかった。左上6、左上7は電気歯髄診断で生活反応を認めなかった。パノラマX線では左上678相当部の上顎洞底より左側上顎洞内に突出した類円形の塊状のX線不透過像が認められた。CTでは左側上顎洞内に上顎洞底から外向性に突出し上顎洞前壁、側壁、後壁と接する病変を認め、病変の内部のdensityは不均一であった。また、病変内部に歯を認めた。左側上顎骨腫瘍と診断し全身麻酔下に摘出術を施行した。病理組織学的所見は病変の内部に埋伏歯を認め、埋伏歯を取り囲むように塊状の不規則な形態の硬組織が認められた。硬組織はセメント質様、或いは骨様で、線維組織は細胞成分が豊富であった。術後経過は良好で術後6ヵ月現在、再発を認めていない。

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2010&ichushi_jid=J01072&link_issn=&doc_id=20100520230002&doc_link_id=%2Fcp8stoma%2F2010%2F005902%2F003%2F0068-0078%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcp8stoma%2F2010%2F005902%2F003%2F0068-0078%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

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出版者・発行元：11  

DOI： 10.1177/0022034509345998

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

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記述言語：英語  

DOI： 10.1016/j.jcms.2009.04.012

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1097/01.ta.0000245948.68844.00

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：CHURCHILL LIVINGSTONE  

Nasolabial cysts are rare non-odontogenic cysts that occur beneath the ala nasi, and debate about their complicated, unique pathogenesis continues. It is widely accepted that these lesions originate from the anlage of the nasolacrimal duct; however, some still think that nasolabial cysts arise from fissural cysts. The authors report a patient with a nasolabial cyst who also had a unilateral cleft lip and palate. This unusual finding may indicate a different origin for nasolabial cysts than what has been accepted in the past.

DOI： 10.1016/j.ijom.2008.04.016

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記述言語：日本語   出版者・発行元：(公社)日本口腔外科学会  

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記述言語：日本語   出版者・発行元：(公社)日本口腔外科学会  

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記述言語：日本語   出版者・発行元：(公社)日本口腔外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

26歳女。口蓋正中部疼痛を主訴とした。既往としてパニック障害、うつ病があり、25歳時より摂食障害を認め、過食と自己誘発性嘔吐を繰り返していた。右側口蓋に周囲硬結を伴う腫脹を認め、その中央部に壊死を伴う潰瘍を認めて口蓋悪性腫瘍を疑った。MRIでは右側口蓋にびまん性の腫脹を伴う境界明瞭な病変を認め、T1強調像で低信号、T2強調像で高信号を示した。潰瘍の生検を行い壊死性唾液腺炎と診断し、潰瘍にエレース軟膏とプロスタンディン軟膏を混和したガーゼを塗布し、保護床を装着して経過観察を行った。潰瘍は治癒傾向を示したが、生検6日後に左側口蓋に新たな潰瘍が出現した。右側病変と類似していたため同様の処置を行い、1ヵ月後に潰瘍は消失し、また経過観察中に過食や自己誘発性嘔吐も改善した。病理組織学的所見で小唾液腺の広範囲な腺房壊死や導管由来の扁平上皮化生を認めたが、粘液細胞の扁平上皮化生は認めず、腺房細胞周囲での著しい肉芽形成や炎症細胞浸潤も認めなかった。

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その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2008&ichushi_jid=J01072&link_issn=&doc_id=20080814280010&doc_link_id=%2Fcp8stoma%2F2008%2F005703%2F011%2F0311-0314%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcp8stoma%2F2008%2F005703%2F011%2F0311-0314%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

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記述言語：日本語   出版者・発行元：(公社)日本口腔外科学会  

41歳女。下垂体腺腫と診断され経蝶形骨洞下垂体腫瘍摘出術を受け、以降末端肥大症の改善目的に持続性ソマトスタチンアナログの継続的投与を受けていた。今回、末端肥大症に伴う不正咬合および下顎前歯部歯間離開の改善目的に当科紹介となった。顔貌所見は顔面高および幅ともに大きく、前額部は突出し、眉部、眼窩外側縁は隆起していた。口腔内所見は舌は肥大し、睡眠時にいびきを伴っていた。上顎中切歯間と下顎前歯部に歯間離開を認め、上下顎中切歯ではover jetが-5mm、over biteが1mmを示し、上下第一大臼歯はIII級の対向関係にあった。側面セファロX線規格写真ではトルコ鞍の風船様拡大を認め、セファロ分析では骨格性下顎前突症を示した。末端肥大症に伴う骨格性下顎前突症および巨舌症と診断し、術前矯正治療後、下顎枝矢状分割術による顎矯正手術および舌縮小術を施行した。術後経過は良好で、術後4年4ヵ月のセファロX線写真分析で良好な下顎位と咬合を認めた。

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その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2008&ichushi_jid=J01073&link_issn=&doc_id=20080430380003&doc_link_id=10.5794%2Fjjoms.54.234&url=https%3A%2F%2Fdoi.org%2F10.5794%2Fjjoms.54.234&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

掲載種別：研究論文（学術雑誌）  

Aim: Peripheral ameloblastoma (PA) is a rare variant of ameloblastoma occurring in the extraosseous region. With regard to the histogenesis of the tumor, two major sources of origin are considered: odontogenic epithelial remnants and the gingival epithelium. In this study, we examined the immunohistochemical profiles of cytokeratins (CKs) and Ki-67 labeling index (LI) of PAs, and discuss the histogenesis and the biologic behavior of the PA. Materials and methods: Eight cases of PA were retrieved from the pathology files of 212 cases of ameloblastoma that had been registered at our hospital. Immunohistochemical staining was performed in seven cases using monoclonal antibodies of six CKs (7, 8, 13, 14, 18, and 19) and Ki-67. Results: All cases of PA expressed CK13, 14, and 19. CK18 was positive staining in six cases, and CK8 in five cases. This staining pattern was similar to that in intraosseous ameloblastomas (IAs). The mean of Ki-67 LI of PAs (1.91%) was significantly lower than that of IAs (4.82%) (P = 0.002). Conclusion: We consider that the PA originates from odontogenic epithelial remnants rather than from the gingival epithelium, and the Ki-67 LI of the tumor is a good prognostic indicator. © 2007 The Authors.

DOI： 10.1111/j.1601-0825.2006.01340.x

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記述言語：日本語   出版者・発行元：(公社)日本口腔外科学会  

1歳2ヵ月、メキシコ人男児。術前所見では右側にTessier No.4顔面裂、左側にNo.5顔面裂(それぞれNo.4 cleft、No.5 cleft)、左側に顎裂部に連続する索状組織を認めた。右眼は開眼不能であり、角膜は肥厚、混濁し、失明していた。生後8ヵ月時に右側斜顔面裂の形成手術、左側の索状組織切除術を施行されたが、審美的・機能的改善が得られなかった。当科入院時、右側披裂部に手術後瘢痕、上唇の披裂を認め、下眼瞼は下方に強く牽引され閉眼不能であった。CTでは右側小眼球症を認め、右側眼窩内容積は左側に比べ狭小であった。右側の骨披裂は乳犬歯相当部から眼窩下縁にかけて、左側の骨披裂は第二乳臼歯相当部から眼窩下縁にかけて存在した。口蓋裂を伴う両側性斜顔面裂、右側No.4 cleft、左側No.5 cleftと診断し、No.4 cleftには連続Z形成術を応用し、No.5 cleftには口角形成術(松矢法)とZ形成術を応用した形成術を行った。術後経過は良好で、白唇、口角、頬部の良好な形態を確認した。

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その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2007&ichushi_jid=J01073&link_issn=&doc_id=20071025390004&doc_link_id=10.5794%2Fjjoms.53.603&url=https%3A%2F%2Fdoi.org%2F10.5794%2Fjjoms.53.603&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

記述言語：日本語   出版者・発行元：大阪大学歯学会  

20歳男。上下左右の大臼歯の骨性癒着を主訴とした。口腔内所見では両側上下顎第2小臼歯、第1大臼歯が低位であり、同部で咬合を認めなかった。X線で両側下顎第2小臼歯、第1大臼歯に歯根膜腔を認めず、骨性癒着を疑った。両側上下顎第1大臼歯、第1小臼歯の低位骨性癒着歯と診断し、右側上下顎第1大臼歯と左側上顎第1大臼歯に対しCorticotomyを施行し、顎間ゴムの矯正装置により咬合誘導を行った。しかし、初回の処置だけで移動を確認したのは右側上顎第1大臼歯のみであり、それ以外の2歯については再手術による海綿骨の離断を追加した。残りの左側下顎第1大臼歯に対しては、Single-tooth dento-osseous osteotomyを施行し、顎間ゴムの矯正装置により咬合誘導を行った。4歯とも移動を確認し、術後4ヵ月のX線で歯根膜スペースの拡大から歯牙の脱臼を認め、術後6ヵ月には歯槽骨の良好な治癒状況を認め、左右臼歯部の咬合関係が回復した。

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記述言語：日本語   出版者・発行元：大阪大学歯学会  

11歳男。学校検診で齲蝕を指摘され、某歯科医院を受診したところパラノラマX線検査で両側下顎第二乳臼歯根尖部にX線透過像を認められ当科に紹介された。諸検査により後続永久歯が先天的に欠損した乳臼歯歯根嚢胞と診断した。局所麻酔下に抜歯+嚢胞摘出術を施行し、術後経過良好であった。当院で1985〜2005年に経験した乳歯歯根嚢胞14例について臨床的検討を行った。男女比は1.8:1、初診時年齢は6〜13歳(平均9.6歳)であった。診断契機は「パノラマX線で偶然発見」が最も多く8例(57.1%)、次いで「顎骨の腫脹」4例(28.6%)、「疼痛」2例(14.3%)の順であった。治療法は抜歯+嚢胞摘出が9例(64.3%)、抜歯+開窓術が5例(35.7%)であった。

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DOI： 10.1111/j.1600-0714.2006.00409.x

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：ELSEVIER SCIENCE BV  

Vascularized bone grafts have become the preferred method of mandibular reconstruction. However, the technique is considered to increase both the operating time and blood loss, which might be associated with an increased morbidity and mortality. We conducted a retrospective analysis of 100 consecutive patients who underwent immediate bridging plate reconstruction. The median follow-up duration was 70 months. The 5-year overall survival rate was 69.9%. Cox multivariate analysis revealed that red blood cell transfusion was an independent prognostic factor for the overall survival. The plate survival with no complications was 62.2% at 5 years. Anterolateral defects and preoperative radiotherapy emerged as an independent adverse factor for plate survival. The use of bridging plates is an option for lateral mandibular reconstruction with no preoperative irradiation to avoid the risk from blood transfusion. (C) 2005 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.oraloncology.2005.03.006

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記述言語：日本語   出版者・発行元：(公社)日本口腔外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：日本語   出版者・発行元：(公社)日本口腔外科学会  

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DOI： 10.1016/j.joms.2005.01.011

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DOI： 10.1111/j.1600-0714.2005.00304.x

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：BRITISH INST RADIOLOGY  

Ameloblastoma is one of the well-known odontogenic tumours that can be associated with calcifying odontogenic cysts (COCs), but only a few reports include detailed clinical and radiographic features. In this paper we demonstrate a case of large ameloblastomatous COC in the mandible. The radiographic examination revealed the presence of a multilocular cystic lesion in the right posterior part of the mandible containing the impacted lower second molar with remarkable expansion toward both lingual and buccal side. This feature was different from the general findings of COC and rather resembled that of ameloblastomas.

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記述言語：日本語   掲載種別：研究論文（学術雑誌）  

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：日本語   出版者・発行元：大阪大学歯学会  

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記述言語：日本語   出版者・発行元：(公社)日本口腔外科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：英語   掲載種別：研究論文（国際会議プロシーディングス）   出版者・発行元：ELSEVIER SCIENCE PUBL B V  

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記述言語：英語   掲載種別：研究論文（国際会議プロシーディングス）   出版者・発行元：ELSEVIER SCIENCE PUBL B V  

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：日本語   出版者・発行元：日本法歯科医学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：日本法歯科医学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

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J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本口腔内科学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

J-GLOBAL

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J-GLOBAL

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記述言語：日本語   出版者・発行元：(NPO)日本法医学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本口腔内科学会  

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記述言語：英語   出版者・発行元：KOREAN ASSOC ORTHODONTISTS  

We report a case involving a young female patient with severe mandibular retrognathism accompanied by mandibular condylar deformity that was effectively treated with Le Fort I osteotomy and two genioplasty procedures. At 9 years and 9 months of age, she was diagnosed with Angle Class III malocclusion, a skeletal Class II jaw relationship, an anterior crossbite, congenital absence of some teeth, and a left-sided cleft lip and palate. Although the anterior crossbite and narrow maxillary arch were corrected by interceptive orthodontic treatment, severe mandibular hypogrowth resulted in unexpectedly severe mandibular retrognathism after growth completion. Moreover, bilateral condylar deformities were observed, and we suspected progressive condylar resorption (PCR). There was a high risk of further condylar resorption with mandibular advancement surgery;. therefore, Le Fort I osteotomy with two genioplasty procedures was performed to achieve counterclockwise rotation of the mandible and avoid ingravescence of the condylar deformities. The total duration of active treatment was 42 months. The maxilla was impacted by 7.0 mm and 5.0 mm in the incisor and molar regions, respectively, while the pogonion was advanced by 18.0 mm. This significantly resolved both skeletal disharmony and malocclusion. Furthermore, the hyoid bone was advanced, the pharyngeal airway space was increased, and the morphology of the mandibular condyle was maintained. At the 30-month follow-up examination, the patient exhibited a satisfactory facial profile. The findings from our case suggest that severe mandibular retrognathism with condylar deformities can be effectively treated without surgical mandibular advancement, thus decreasing the risk of PCR.

DOI： 10.4041/kjod.2016.46.6.395

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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DOI： 10.1016/j.ajoms.2016.03.009

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DOI： 10.18926/AMO/54420

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：日本画像医学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

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記述言語：日本語   出版者・発行元：岡山歯学会  

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記述言語：日本語   出版者・発行元：(一社)日本口腔内科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(公社)日本矯正歯科学会  

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記述言語：日本語   出版者・発行元：社団法人 日本口腔外科学会  

Substantial progress has been made in the development of cell therapy; however, there have been no practical applications related to bone regeneration. We analyzed mouse bone-marrow-derived lineage (-) cells and compact bone-derived lineage (-) cells as candidate mesenchymal stem cells (MSCs), and confirmed bone regeneration &lt;i&gt;in vivo&lt;/i&gt;. Materials and Methods: Bone marrow-derived cells were collected from the femurs of 5-week-old C57-GFP male mice. Bone marrow-derived cells were harvested by removing the epiphyses and flushing with medium, after which the femurs were broken into approximately 1 mm&lt;sup&gt;3&lt;/sup&gt; fragments and treated with collagenase II. Cells released from the compact bone were aspirated and cultured with the bone fragments. These cells were cultured in alpha-MEM supplemented with 20% fetal bovine serum at 37℃ in a 5% CO&lt;sub&gt;2&lt;/sub&gt; humidified incubator for 3 days, and the difference between bone marrow-derived cells and compact bonederived cells was investigated. After 3 days of incubation, cells were labeled with allophycocyanin (APC) antilineage antibody cocktail, analyzed by flow cytometry, and sorted into lineage (+) or lineage (-) populations. Cells that had acquired lineage (-) were then induced to differentiate into osteogenic lineages by incubation with osteogenic media for 3 days. Differentiated cells and 50 mg of beta-TCP were mixed to form an osteogenic pellet. Pellet samples were implanted into subcutaneous pouches of SCID mice and retrieved after 4 weeks. Tissue samples were fixed in 1.5% paraformaldehyde and embedded in paraffin. Sections were stained with hematoxylin and eosin, and immunohistochemical analysis were performed using anti-GFP antibody. Results: Approximately 90% of bone marrow-derived cells expressed lineage markers. However, only 40% of compact bone-derived cells expressed these markers. Both bone marrow-derived and compact bone-derived cells sorted as lineage (-) showed fibroblastic shapes and plastic-adhesion ability. The number of lineage (-) cells from an individual mouse femur was about 10,000 from bone marrow and about 400,000 from compact bone. Moreover, we found that cells isolated from compact bone and sorted as lineage (-) cells were capable of supporting bone formation &lt;i&gt;in vivo&lt;/i&gt;. The methods and results described here may facilitate understanding of MSC biology and lead to clinical applications.

DOI： 10.5794/jjoms.59.223

CiNii Article

J-GLOBAL

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記述言語：英語  

CiNii Article

CiNii Books

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

J-GLOBAL

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J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本頭頸部癌学会  

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(公社)日本口腔外科学会  

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記述言語：日本語   出版者・発行元：(公社)日本口腔外科学会  

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記述言語：日本語   出版者・発行元：(公社)日本口腔外科学会  

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記述言語：日本語   掲載種別：研究発表ペーパー・要旨（全国大会，その他学術会議）   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：日本語   出版者・発行元：(公社)日本口腔外科学会  

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記述言語：日本語   出版者・発行元：(公社)日本口腔外科学会  

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記述言語：日本語   掲載種別：研究発表ペーパー・要旨（全国大会，その他学術会議）   出版者・発行元：(公社)日本口腔外科学会  

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記述言語：英語   出版者・発行元：MOSBY-ELSEVIER  

Objective. Maxillary anterior segmental distraction osteogenesis (MASDO) is an effective surgical orthodontic treatment for the retruded maxilla in cleft lip and palate because of its benefit of the conservation of velopharyngeal function. Some reports showed MASDO using various devices, but they do not allow the rotational movement of the distracted anterior segment. In this article, we showed MASDO using hybrid distracters (DynaForm System: Stryker Osteosymthesis, Leibinger Micro Implants, Kalamazoo, MI), which allow the advance of the distracted segment with rotational movement.
Method. The hybrid distractor with 4 metal arms is secured beyond both alveolar osteotomy lines on each side. These 2 distractors permit rotational movement of the segment by controlling the amount of advancement on each side.
Results. For 6 patients with cleft lip and palate, MASDO using hybrid distractors was performed and the anterior segment moved at planned positions without any complications except lip discomfort, which disappeared after removal of the distractor.
Conclusion. MASDO, using an institutionally diagnosed hybrid distractor can successfully achieve the necessary rotational movements of the anterior maxillary segment owing to its design, which incorporates some mechanical flexibility. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;110:292-300)

DOI： 10.1016/j.tripleo.2010.01.017

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記述言語：日本語   出版者・発行元：(一社)日本顎関節学会  

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記述言語：日本語   出版者・発行元：日本口腔外科学会  

Septo-optic-pituitary dysplasia (SOPD) is a rare disorder first described by de Morsier in 1956. It is a syndrome characterized by optic nerve hypoplasia, hypothalamic pituitary insufficiency, and absence of the septum pellucidum.We report a case of SOPD associated with bilateral cleft lip and alveolus.The patient was a 4-day-old boy. He had pituitary hypoplasia, thyroid insufficiency, micropthalmia, coloboma, cleft lip and alveolus, and premaxillary hypoplasia. At the age of 3 months, we performed primary lip repair. As a postoperative complication, difficulty in oral feeding and ischemic necrosis of the premaxilla occurred. Now at the age of 6 years 1 month, he has no right-sided vision or pituitary insufficiency. The prognosis of patients with SOPD is good, but it is necessary to medically treat pituitary insufficiency as soon as possible. Therefore, early detection of SOPD in patients with cleft lip and/or palate associated with premaxillary hypoplasia and eye manifestations is important.

DOI： 10.5794/jjoms.56.179

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記述言語：日本語   出版者・発行元：大阪大学歯学会  

67歳男。右側下顎第二大臼歯に咬合痛を自覚し、生剤投与、および根管治療を受け一度症状は消失した。しかし、再度の同部自発痛と頬側歯肉の腫脹、第二大臼歯遠心歯肉ポケットからの排膿を認めた。局所洗浄と抗生剤投薬、および再度の根管治療を受けるも、その後も定期的に同様の症状が再燃するため紹介受診した。右側下顎智歯含歯性嚢胞と診断し、全身麻酔下に右側下顎第二大臼歯抜歯術、右側下顎埋伏智歯抜歯術嚢胞摘出術を施行した。摘出標本の病理組織診断は顎骨中心性扁平上皮癌であった。造影CT、造影MRI、頸部超音波エコー検査、胸部単純XPによる局所および全身の精査後、右側第一大臼歯から下顎枝にかけて下顎管を含んだ下顎骨辺縁切除術、金属プレートによる下顎骨の補強、および右側レベル1リンパ節の郭清手術を施行した。術後7ヵ月を経過し再発、転移なく経過観察中である。

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記述言語：英語   出版者・発行元：ELSEVIER SCIENCE BV  

The optimal method of management of clinical N0 neck in squamous cell carcinoma of the oral cavity remains controversial. We used decision analysis to determine the current optimal strategy in comparison with observation of the neck and elective neck dissection. A total of 165 previously untreated patients with N0 classification were investigated. Probabilities of each recurrence were calculated and probabilities of being cured in each event were substituted with the 5-year overall survival calculation with Kaplan-Meier method. A sensitivity analysis was performed to determine the optimal threshold for treatment of the N0 neck. The threshold of N0 neck was calculated using the formula with putting the three probabilities of being cured. In this study the threshold was estimated at 44.4%. N0 neck of squamous cell carcinoma of the oral cavity should be observed if the probability of occult metastasis is less than 44.4%. Proper calculation of three probabilities of being cured in each institution will make a decision of the optimal method of clinical N0 neck by using the threshold formula. (C) 2009 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.oraloncology.2009.03.013

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記述言語：英語   出版者・発行元：MOSBY-ELSEVIER  

DOI： 10.1016/j.tripleo.2009.06.007

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記述言語：英語   出版者・発行元：JAPANESE PHARMACOLOGICAL SOC  

Myeloid cell leukemia-1(Mcl-1), a member of the B-cell lymphoma-2 (Bcl-2) family, has been reported to be a critical survival factor in hematopoietic cells, yet little data exists for a role of Mcl-1 in human oral squamous cell carcinoma (SCC). A high level expression of Mcl-1 was observed in tumor cells of human primary SCC, lymph node metastasis tissues, and SCC cell lines. We manipulated expression of Mcl-1 protein in SCC cells by small interfering RNA (siRNA) for Mcl-1 and observed that Mcl-1 siRNA inhibited the growth of SCCs accompanied with apoptosis. Combination therapy of Mcl-1 siRNA and anti-tumor drug drastically inhibited the cell growth In comparison to that in each single treatment. In addition, phosphorylation of focal adhesion kinase (FAK) was decreased by treatment with Mcl-1 siRNA, resulting in decreases in phosphorylation of MEK1/2 and MAPK. The cell growth inhibition caused by knockdown of Mcl-1 was suggested to be mainly a result of suppression of proliferation via the inhibition of intracellular FAK/MAPK signaling pathways. These results imply a potentially important and novel role of the inhibition of Mcl-1 function by the use of specific siRNA in the treatment of SCC.

DOI： 10.1254/jphs.08339FP

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記述言語：英語   出版者・発行元：MOSBY-ELSEVIER  

Intraductal papilloma is a rare benign salivary gland tumor. This lesion is commonly observed in the duct of the minor salivary gland, predominantly in lip and buccal mucosa, but the case in the sublingual region is quite rare. This report shows a first case of intraductal papilloma developed in minor salivary gland of sublingual region.
A 47-year-old Japanese male was referred to our hospital with painless submucosal nodule in the right sublingual region beside Wharton&apos;s duct orifice. The excised specimen was histologically diagnosed as intraductal papilloma of minor salivary gland, according to the microscopic finding of the papillary growth of ductal epithelium into the ductal space with fibrovascular core. Immunohistochemical study showed the tumor cells originated from ductal luminal cells because of positive Cytokeratin 18 and 7 staining in both types of cells. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;107:e34-e37)

DOI： 10.1016/j.tripleo.2009.01.019

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記述言語：英語   出版者・発行元：W B SAUNDERS CO LTD  

Dental, surgery performed with high speed instruments, such as a dental turbine, air motor, or micro-engine handpiece, produces a large amount of splattering and particles, which can be contaminated by micro-organisms from the oral cavity. It has been speculated that such particulate mists contain blood-based elements. In the present study, we investigated whether blood-contaminated aerosol was present in a room where oral surgery was performed with high speed instruments. An extra-oral evacuator system was used for sample collection (N = 132). For the experiment, a non-woven towel. was set on the nozzle of the evacuator as a filter and invisible mist was collected at distances of 20, 60 and 100 cm from the surgical site. A leucomalachite green presumptive test was performed with each fitter after every tooth extraction. At locations 20 and 100 cm from the surgical site, 76% and 57%, respectively, of the particulates were positive in blood presumptive tests. Based on our results, we consider that blood-contaminated materials have the potential to be suspended in air as blood-contaminated aerosol. These results indicate the risk of cross-infection at the dental practice for immunocompromised patients as well as healthy personnel. (c) 2008 The Hospital Infection Society. Published by Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.jhin.2008.12.005

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記述言語：英語   出版者・発行元：W B SAUNDERS CO LTD  

Dental, surgery performed with high speed instruments, such as a dental turbine, air motor, or micro-engine handpiece, produces a large amount of splattering and particles, which can be contaminated by micro-organisms from the oral cavity. It has been speculated that such particulate mists contain blood-based elements. In the present study, we investigated whether blood-contaminated aerosol was present in a room where oral surgery was performed with high speed instruments. An extra-oral evacuator system was used for sample collection (N = 132). For the experiment, a non-woven towel. was set on the nozzle of the evacuator as a filter and invisible mist was collected at distances of 20, 60 and 100 cm from the surgical site. A leucomalachite green presumptive test was performed with each fitter after every tooth extraction. At locations 20 and 100 cm from the surgical site, 76% and 57%, respectively, of the particulates were positive in blood presumptive tests. Based on our results, we consider that blood-contaminated materials have the potential to be suspended in air as blood-contaminated aerosol. These results indicate the risk of cross-infection at the dental practice for immunocompromised patients as well as healthy personnel. (c) 2008 The Hospital Infection Society. Published by Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.jhin.2008.12.005

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

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記述言語：英語   出版者・発行元：I O S PRESS  

A novel computer-assisted 3-D simulation for osteotomy and CAD/CAM fabrication of surgical splints consider the relative inter-bone interference and space after bone translation were developed. CT image of a patient for osteotomy was operated and simulation of surgery for deformation, segmentation, displacement of the bone was processed effectively by virtual reality haptic device PHANTOM. CAD of a bite splint before surgery and after bone displacement was done in the process of simulation. CAM of resin bite splints was done by precise Rapid Prototyping CAM machine All fabricated splint were sufficiently functioned to determine the position of jaws.

DOI： 10.3233/978-1-58603-964-6-331

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記述言語：英語   出版者・発行元：MOSBY-ELSEVIER  

Vertical alveolar augmentation by distraction osteogenesis has become a standard pretreatment of dental implants due to the main benefit of lack of donor site complications, and many reports have shown its benefit with various types of alveolar distractors. However, autogenous bone transplantation and/or guided bone regeneration techniques are still the standard treatment for correcting a narrow alveolar ridge because of few commercially available distractors for alveolar widening. In this article, we treated a case by a mesh-plate type of alveolar widening distractor for a narrow posterior mandibular alveolar ridge after extirpation of a large jaw cyst. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;106:e1-e7)

DOI： 10.1016/j.tripleo.2008.07.006

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記述言語：英語   出版者・発行元：MOSBY-ELSEVIER  

Vertical alveolar augmentation by distraction osteogenesis has become a standard pretreatment of dental implants due to the main benefit of lack of donor site complications, and many reports have shown its benefit with various types of alveolar distractors. However, autogenous bone transplantation and/or guided bone regeneration techniques are still the standard treatment for correcting a narrow alveolar ridge because of few commercially available distractors for alveolar widening. In this article, we treated a case by a mesh-plate type of alveolar widening distractor for a narrow posterior mandibular alveolar ridge after extirpation of a large jaw cyst. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;106:e1-e7)

DOI： 10.1016/j.tripleo.2008.07.006

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記述言語：英語   出版者・発行元：MOSBY-ELSEVIER  

In this report, we show a case of the extensive nasopalatine duct cyst showing remarkable nasolabial protrusion. CT and MR examinations showed remarkable expansion of the extraosseous part of the lesion toward anterior and lateral sides, and this finding is considered to show the rather aggressive nature of this common cystic lesion after penetration of the maxillary cortex. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008; 106: e46-e50)

DOI： 10.1016/j.tripleo.2008.05.046

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記述言語：英語   出版者・発行元：MOSBY-ELSEVIER  

In this report, we show a case of the extensive nasopalatine duct cyst showing remarkable nasolabial protrusion. CT and MR examinations showed remarkable expansion of the extraosseous part of the lesion toward anterior and lateral sides, and this finding is considered to show the rather aggressive nature of this common cystic lesion after penetration of the maxillary cortex. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008; 106: e46-e50)

DOI： 10.1016/j.tripleo.2008.05.046

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：英語   出版者・発行元：MOSBY-ELSEVIER  

Maxillary distraction osteogenesis using intraoral distractors is now one of the standard treatments of maxillary retrusion. This report shows 2 cases of breakage of this internal maxillary distractor in patients with cleft lip and palate; one was observed during the distraction period and the other was during the retention period. The first case required a rotational movement of the distraction segment, and this movement caused the laterally dislocation of the posterior part of the distractor, where the distractor suffered some mechanical forces by mouth opening. In the latter case, breakage of distractor was observed on the radiographs taken 3 months after distraction and this complication may have been caused by mechanical force by occlusion and mastication. Both breakages were found at the joint of the anchorage plate and the extension rod, which has some flexibility for adjusting the plate to the bone surface. Therefore, surgeons should pay special attention for this mechanical weak area in this distractor not only during the advancement period, but also during the retention period and should avoid unnecessary frequent bending for adopting the bone surface, which directly weakens the joint.

DOI： 10.1016/j.tripleo.2008.03.035

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記述言語：英語   出版者・発行元：MOSBY-ELSEVIER  

Maxillary distraction osteogenesis using intraoral distractors is now one of the standard treatments of maxillary retrusion. This report shows 2 cases of breakage of this internal maxillary distractor in patients with cleft lip and palate; one was observed during the distraction period and the other was during the retention period. The first case required a rotational movement of the distraction segment, and this movement caused the laterally dislocation of the posterior part of the distractor, where the distractor suffered some mechanical forces by mouth opening. In the latter case, breakage of distractor was observed on the radiographs taken 3 months after distraction and this complication may have been caused by mechanical force by occlusion and mastication. Both breakages were found at the joint of the anchorage plate and the extension rod, which has some flexibility for adjusting the plate to the bone surface. Therefore, surgeons should pay special attention for this mechanical weak area in this distractor not only during the advancement period, but also during the retention period and should avoid unnecessary frequent bending for adopting the bone surface, which directly weakens the joint.

DOI： 10.1016/j.tripleo.2008.03.035

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：英語   出版者・発行元：W B SAUNDERS CO-ELSEVIER INC  

Purpose: To evaluate the incidence of blood exposure during outpatient oral surgery from splattering caused by use of high-speed rotary instruments at the Referral and Teaching Center, University Dental Hospital.
Materials and Methods: Twenty-five consecutive patients who had impacted mandibular third molars were selected. The attending surgeon wore an operation gown and visor mask, and carried out the tooth extraction with the regular procedure. We counted the number of bloodstains found on the operation gown and visor mask, and confirmed the presence of diluted and invisible bloodstains using a leucomalachite green presumptive test, which was able to detect dilutions up to 1:4,000.
Results: There were 469 separate bloodstains on the gown and visor mask of oral surgeons, which came from 19 (76%) of 25 patients during impacted mandibular third molar surgery. Presumptive tests for invisible bloodstains resulted in 1,206 positive reactions, 2.57-fold greater than the visible stains, from 88% of the cases. All of the surgeons were right-handed and the common areas of staining were the right forearm, face, and thorax regions.
Conclusions: Dental procedures with high-speed instruments exposed surgeons to possible blood-borne infections by splashing in nearly 90% of the cases. Greater than 50% of the stains were invisible to the naked eye. Based on our results, strict compliance with barrier precautions, including routine use of an operation gown and visor mask, is recommended whenever oral surgery is carried out with high-speed rotary instruments. (C) 2008 American Association of Oral and Maxillofacial Surgeons.

DOI： 10.1016/j.joms.2007.06.663

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記述言語：英語   出版者・発行元：W B SAUNDERS CO-ELSEVIER INC  

Purpose: To evaluate the incidence of blood exposure during outpatient oral surgery from splattering caused by use of high-speed rotary instruments at the Referral and Teaching Center, University Dental Hospital.
Materials and Methods: Twenty-five consecutive patients who had impacted mandibular third molars were selected. The attending surgeon wore an operation gown and visor mask, and carried out the tooth extraction with the regular procedure. We counted the number of bloodstains found on the operation gown and visor mask, and confirmed the presence of diluted and invisible bloodstains using a leucomalachite green presumptive test, which was able to detect dilutions up to 1:4,000.
Results: There were 469 separate bloodstains on the gown and visor mask of oral surgeons, which came from 19 (76%) of 25 patients during impacted mandibular third molar surgery. Presumptive tests for invisible bloodstains resulted in 1,206 positive reactions, 2.57-fold greater than the visible stains, from 88% of the cases. All of the surgeons were right-handed and the common areas of staining were the right forearm, face, and thorax regions.
Conclusions: Dental procedures with high-speed instruments exposed surgeons to possible blood-borne infections by splashing in nearly 90% of the cases. Greater than 50% of the stains were invisible to the naked eye. Based on our results, strict compliance with barrier precautions, including routine use of an operation gown and visor mask, is recommended whenever oral surgery is carried out with high-speed rotary instruments. (C) 2008 American Association of Oral and Maxillofacial Surgeons.

DOI： 10.1016/j.joms.2007.06.663

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記述言語：英語   出版者・発行元：W B SAUNDERS CO-ELSEVIER INC  

Purpose: To evaluate the incidence of blood exposure during outpatient oral surgery from splattering caused by use of high-speed rotary instruments at the Referral and Teaching Center, University Dental Hospital.
Materials and Methods: Twenty-five consecutive patients who had impacted mandibular third molars were selected. The attending surgeon wore an operation gown and visor mask, and carried out the tooth extraction with the regular procedure. We counted the number of bloodstains found on the operation gown and visor mask, and confirmed the presence of diluted and invisible bloodstains using a leucomalachite green presumptive test, which was able to detect dilutions up to 1:4,000.
Results: There were 469 separate bloodstains on the gown and visor mask of oral surgeons, which came from 19 (76%) of 25 patients during impacted mandibular third molar surgery. Presumptive tests for invisible bloodstains resulted in 1,206 positive reactions, 2.57-fold greater than the visible stains, from 88% of the cases. All of the surgeons were right-handed and the common areas of staining were the right forearm, face, and thorax regions.
Conclusions: Dental procedures with high-speed instruments exposed surgeons to possible blood-borne infections by splashing in nearly 90% of the cases. Greater than 50% of the stains were invisible to the naked eye. Based on our results, strict compliance with barrier precautions, including routine use of an operation gown and visor mask, is recommended whenever oral surgery is carried out with high-speed rotary instruments. (C) 2008 American Association of Oral and Maxillofacial Surgeons.

DOI： 10.1016/j.joms.2007.06.663

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記述言語：英語   出版者・発行元：W B SAUNDERS CO-ELSEVIER INC  

Purpose: To evaluate the incidence of blood exposure during outpatient oral surgery from splattering caused by use of high-speed rotary instruments at the Referral and Teaching Center, University Dental Hospital.
Materials and Methods: Twenty-five consecutive patients who had impacted mandibular third molars were selected. The attending surgeon wore an operation gown and visor mask, and carried out the tooth extraction with the regular procedure. We counted the number of bloodstains found on the operation gown and visor mask, and confirmed the presence of diluted and invisible bloodstains using a leucomalachite green presumptive test, which was able to detect dilutions up to 1:4,000.
Results: There were 469 separate bloodstains on the gown and visor mask of oral surgeons, which came from 19 (76%) of 25 patients during impacted mandibular third molar surgery. Presumptive tests for invisible bloodstains resulted in 1,206 positive reactions, 2.57-fold greater than the visible stains, from 88% of the cases. All of the surgeons were right-handed and the common areas of staining were the right forearm, face, and thorax regions.
Conclusions: Dental procedures with high-speed instruments exposed surgeons to possible blood-borne infections by splashing in nearly 90% of the cases. Greater than 50% of the stains were invisible to the naked eye. Based on our results, strict compliance with barrier precautions, including routine use of an operation gown and visor mask, is recommended whenever oral surgery is carried out with high-speed rotary instruments. (C) 2008 American Association of Oral and Maxillofacial Surgeons.

DOI： 10.1016/j.joms.2007.06.663

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

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記述言語：日本語   出版者・発行元：社団法人 日本口腔外科学会  

Synovial chondromatosis is a non-neoplastic monoarticular condition that is uncommon in the temporomandibular joint (TMJ). A 31-year-old patient with synovial chondromatosis of theleft TMJ was followed for 5 years before operation. Magnetic resonance images showed the longitudinal course of synovial chondromatosis. The synovial membrane increased in thickness and then protruded into the joint cavity and produced loose bodies. The MR findings of this case show the longitudinal course of synovial chondromatosis of the TMJ over time.

DOI： 10.5794/jjoms.54.59

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記述言語：英語   出版者・発行元：INT AMER ASSOC DENTAL RESEARCHI A D R/A A D R  

The finding that the vomer plays a crucial role in maxillary growth suggests that the bilateral cleft configuration of unilateral cleft lip and palate (UCLP), in which the vomer is detached from the non-cleft-side secondary hard palate, negatively influences palatal development, and this hypothesis was tested. Sixty persons with complete UCLP, including those with the vomer detached from (n = 30, b-UCLP) and attached to (n = 30, u-UCLP) the secondary hard palate, were analyzed morphologically, with the use of cast models taken at 10 days, 3 mos, and 12 mos of age. The anterio- posterior palatal length at 12 mos of age in those with b-UCLP was significantly shorter than that in those with u-UCLP, by 8.7% (p &lt; 0.05). In addition, palatal width development in the first year in those with b-UCLP was also significantly retarded. These results suggest that the uncommon bilateral cleft subtype in UCLP should be included in the cleft classification.

DOI： 10.1177/154405910808700212

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記述言語：英語   出版者・発行元：MOSBY-ELSEVIER  

Objective. Surgical-assisted rapid palatal expansion includes various treatment procedures for solving transverse maxillary deficiencies, especially in cases with a matured palatal suture. Recent introduction of the concept of distraction osteogenesis has contributed to generalize this useful treatment and to develop some bone-borne devices that will not cause the problems found in cases treated by tooth-supported palatal expander. This report shows a conventional bone-borne distractor using commercially available orthodontic palatal expansion screws.
Method. The distractor consists of 2 parts: one is a commercially available orthodontic palatal expansion screw ( Hyrax type, Fan style) and another is a screw-ring, which is one of the attached parts of the mandibular distraction system. The bone screws are inserted transmucosally to the palatal bone via the screw-rings.
Result. The palatal distractor can be applied to varied palatal shapes and can expand the palate without any trouble.
Conclusion. This conventional palatal distractor may contribute to generalize the transpalatal maxillary distraction osteogenesis for cases with maxillary teeth problems.

DOI： 10.1016/j.tripleo.2007.08.022

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記述言語：英語  

Objective: Surgical-assisted rapid palatal expansion includes various treatment procedures for solving transverse maxillary deficiencies, especially in cases with a matured palatal suture. Recent introduction of the concept of distraction osteogenesis has contributed to generalize this useful treatment and to develop some bone-borne devices that will not cause the problems found in cases treated by tooth-supported palatal expander. This report shows a conventional bone-borne distractor using commercially available orthodontic palatal expansion screws. Method: The distractor consists of 2 parts: one is a commercially available orthodontic palatal expansion screw (Hyrax type, Fan style) and another is a screw-ring, which is one of the attached parts of the mandibular distraction system. The bone screws are inserted transmucosally to the palatal bone via the screw-rings. Result: The palatal distractor can be applied to varied palatal shapes and can expand the palate without any trouble. Conclusion: This conventional palatal distractor may contribute to generalize the transpalatal maxillary distraction osteogenesis for cases with maxillary teeth problems. © 2008 Mosby, Inc. All rights reserved.

DOI： 10.1016/j.tripleo.2007.08.022

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記述言語：英語   出版者・発行元：ELSEVIER IRELAND LTD  

In this study, we found that a certain motor branch of glossopharyngeal (IX) motor nerves stably exhibits not only inspiratory activity but also expiratory activity with pons removal in neonatal rat brainstem-spinal cord preparations in vitro. Because this finding indicates that IX expiratory activity is masked by an inhibitory mechanism operating in the pons, we sought to determine the candidate neurons that exert an inhibitory effect on IX expiratory activity. IX expiratory activity was observed when only the pons was perfused with noradrenaline (NA) or clonidine (alpha 2 adrenergic receptor agonist), but not when NA and yohimbine (alpha 2 adrenergic receptor antagonist) were perfused together. IX expiratory activity was also observed following the removal of the dorsal pons but not the ventral pons. The local administration of clonidine into the bilateral locus coeruleus (LC) evoked burst discharges during the expiratory phase in the IX motor rootlet. These results suggest that neurons in the LC that possess an a2 adrenergic receptor on the membrane surface exert a tonic inhibitory effect on IX expiratory activity in neonatal rat brainstem-spinal cord preparations. (c) 2007 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

DOI： 10.1016/j.neures.2007.09.001

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記述言語：英語   出版者・発行元：ELSEVIER IRELAND LTD  

In this study, we found that a certain motor branch of glossopharyngeal (IX) motor nerves stably exhibits not only inspiratory activity but also expiratory activity with pons removal in neonatal rat brainstem-spinal cord preparations in vitro. Because this finding indicates that IX expiratory activity is masked by an inhibitory mechanism operating in the pons, we sought to determine the candidate neurons that exert an inhibitory effect on IX expiratory activity. IX expiratory activity was observed when only the pons was perfused with noradrenaline (NA) or clonidine (alpha 2 adrenergic receptor agonist), but not when NA and yohimbine (alpha 2 adrenergic receptor antagonist) were perfused together. IX expiratory activity was also observed following the removal of the dorsal pons but not the ventral pons. The local administration of clonidine into the bilateral locus coeruleus (LC) evoked burst discharges during the expiratory phase in the IX motor rootlet. These results suggest that neurons in the LC that possess an a2 adrenergic receptor on the membrane surface exert a tonic inhibitory effect on IX expiratory activity in neonatal rat brainstem-spinal cord preparations. (c) 2007 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

DOI： 10.1016/j.neures.2007.09.001

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記述言語：英語   出版者・発行元：AMER SOC NEURORADIOLOGY  

BACKGROUND AND PURPOSE: The presence of cervical lymph node metastases is an important prognostic factor for oral tongue cancer. The accurate preoperative assessment is essential for treatment. Several studies have suggested that histologic tumor thickness is related to the metastases. The aim of this study was to determine whether MR images of oral tongue tumor have the potential to predict cervical lymph node metastases.
MATERIALS AND METHODS: A total of 43 patients with squamous cell carcinoma of the oral tongue were investigated. Tumor thickness, sublingual distance between tumor and sublingual space, and paralingual distance between tumor and paralingual space, as determined from coronal MR imaging, were preoperatively estimated. Logistic regression analysis was used to identify independent predictors of lymph node metastases.
RESULTS: Univariate logistic regression analysis showed that T classification, N classification, and 3 measured MR imaging distances (millimeters) were significantly associated with lymph node metastases. Multivariate logistic regression analysis showed that tumor thickness (odds ratio, 1.34; 95% confidence interval [CI], 1.11-1.63; P &lt;.005) and paralingual distance (odds ratio, 0.53; 95% Cl, 0.35-0.82; P &lt;.005) were significant predictors for lymph node metastases. The probability of metastases was estimated with these models. The preoperative decision (20% probability) as to whether to perform neck dissection could be based on tumor thickness of &gt;9.7 mm and paralingual distance of &lt;5.2 mm.
CONCLUSION: MR images provide satisfactory accuracy for the preoperative estimation of the tumor thickness and the paralingual distance, which are valuable for predicting cervical lymph node metastases.

DOI： 10.3174/ajnr.A0749

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：JAPANESE PHARMACOLOGICAL SOC  

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記述言語：英語   出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS  

DOI： 10.1097/01.prs.0000267435.17767.0a

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記述言語：日本語   出版者・発行元：(公社)日本口腔外科学会  

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記述言語：英語   出版者・発行元：MOSBY-ELSEVIER  

Congenital granular cell lesion (CGCL) is well known to appear as the congenital epulis, predominantly on the median maxillary alveolar ridge. This lesion rarely occurs on the tongue, and only 7 cases, including 4 cases with simultaneous occurrence on the alveolar ridge, have been reported in the English literature. In this report, we report a case of congenital granular cell lesion seen on the tongue. The patient was a 7-day-old Japanese girl who presented with a polypoid mass on the anterior ventral surface near the tip of the tongue. The lesion was excised at 4 months, and its histological examination revealed large granular cells. Immunochemical staining by S- 100 was negative, and it was diagnosed as congenital granular cell lesion.

DOI： 10.1016/j.tripleo.2007.01.038

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記述言語：英語   出版者・発行元：MOSBY-ELSEVIER  

Congenital granular cell lesion (CGCL) is well known to appear as the congenital epulis, predominantly on the median maxillary alveolar ridge. This lesion rarely occurs on the tongue, and only 7 cases, including 4 cases with simultaneous occurrence on the alveolar ridge, have been reported in the English literature. In this report, we report a case of congenital granular cell lesion seen on the tongue. The patient was a 7-day-old Japanese girl who presented with a polypoid mass on the anterior ventral surface near the tip of the tongue. The lesion was excised at 4 months, and its histological examination revealed large granular cells. Immunochemical staining by S- 100 was negative, and it was diagnosed as congenital granular cell lesion.

DOI： 10.1016/j.tripleo.2007.01.038

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

CiNii Article

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

CiNii Article

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

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記述言語：英語   出版者・発行元：BLACKWELL PUBLISHING  

Leiomyomatous hamartoma (LH) is congenital lesion rarely seen in oral cavity. In English literature, all reported cases appeared as solitary lesion in alveolar ridge or the tongue, and there have never been a report showing a case of multiple occurrence of this lesion. A quite rare case of multiple LH occurred in a 2-year-old Japanese boy is presented. A polypoid lesion was presented at incisive papilla and two isolated lesions in the tongue dorsum, one appeared as a polypoid mass in the posterior dorsum and other as a small spindle-shaped agger in the anterior dorsum. All of them were histologically diagnosed as LH.

DOI： 10.1111/j.1600-0714.2007.00518.x

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記述言語：英語   出版者・発行元：W B SAUNDERS CO-ELSEVIER INC  

DOI： 10.1016/j.joms.2005.10.062

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記述言語：英語   出版者・発行元：W B SAUNDERS CO-ELSEVIER INC  

DOI： 10.1016/j.joms.2005.10.062

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

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記述言語：英語   出版者・発行元：NATURE PUBLISHING GROUP  

Ossifying fibroma and fibrous dysplasia of the jaw are maxillofacial fibro-osseous lesions that should be distinguished each other by a pathologist because they show distinct patterns of disease progression. However, both lesions often show similar histological and radiological features, making distinction between the two a diagnostic dilemma. In this study, we performed immunological and molecular analyses of five ossifying fibromas, four cases of extragnathic fibrous dysplasia, and five cases of gnathic fibrous dysplasia with typical histological and radiographic features. First, we examined the difference between fibrous dysplasia and ossifying fibroma in the expression of Runx2 (which determined osteogenic differentiation from mesenchymal stem cells) and other osteogenic markers. Fibroblastic cells in fibrous dysplasia and ossifying fibroma showed strong Runx2 expression in the nucleus. The bone matrices of both lesions showed similar expression patterns for all markers tested except for osteocalcin. Immunoreactivity for osteocalcin was strong throughout calcified regions in fibrous dysplasia, but weak in ossifying fibroma lesions. Second, we performed PCR analysis with peptide nucleic acid (PNA) for mutations at the Arg(201) codon of the alpha subunit of the stimulatory G protein gene (GNAS), which has reported to be a marker for extragnathic fibrous dysplasia. All nine cases of extragnathic or gnathic fibrous dysplasia were positive for this mutation. On the other hand, none of the five cases of ossifying fibroma showed the mutation. These findings indicate that although fibrous dysplasia and ossifying fibroma are similar disease entities, especially in the demonstration of the osteogenic lineage in stromal fibroblast-like cells, they show distinct differences that can be revealed by immunohistochemical detection of osteocalcin expression. Furthermore, PCR analysis with PNA for GNAS mutations at the Arg(201) codon is a useful method to differentiate between fibrous dysplasia and ossifying fibroma.

DOI： 10.1038/modpathol.3800753

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記述言語：英語   出版者・発行元：NATURE PUBLISHING GROUP  

Ossifying fibroma and fibrous dysplasia of the jaw are maxillofacial fibro-osseous lesions that should be distinguished each other by a pathologist because they show distinct patterns of disease progression. However, both lesions often show similar histological and radiological features, making distinction between the two a diagnostic dilemma. In this study, we performed immunological and molecular analyses of five ossifying fibromas, four cases of extragnathic fibrous dysplasia, and five cases of gnathic fibrous dysplasia with typical histological and radiographic features. First, we examined the difference between fibrous dysplasia and ossifying fibroma in the expression of Runx2 (which determined osteogenic differentiation from mesenchymal stem cells) and other osteogenic markers. Fibroblastic cells in fibrous dysplasia and ossifying fibroma showed strong Runx2 expression in the nucleus. The bone matrices of both lesions showed similar expression patterns for all markers tested except for osteocalcin. Immunoreactivity for osteocalcin was strong throughout calcified regions in fibrous dysplasia, but weak in ossifying fibroma lesions. Second, we performed PCR analysis with peptide nucleic acid (PNA) for mutations at the Arg(201) codon of the alpha subunit of the stimulatory G protein gene (GNAS), which has reported to be a marker for extragnathic fibrous dysplasia. All nine cases of extragnathic or gnathic fibrous dysplasia were positive for this mutation. On the other hand, none of the five cases of ossifying fibroma showed the mutation. These findings indicate that although fibrous dysplasia and ossifying fibroma are similar disease entities, especially in the demonstration of the osteogenic lineage in stromal fibroblast-like cells, they show distinct differences that can be revealed by immunohistochemical detection of osteocalcin expression. Furthermore, PCR analysis with PNA for GNAS mutations at the Arg(201) codon is a useful method to differentiate between fibrous dysplasia and ossifying fibroma.

DOI： 10.1038/modpathol.3800753

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記述言語：英語   出版者・発行元：BLACKWELL PUBLISHING  

Peripheral ameloblastomas (PAs) of the extragingival areas are extremely rare. To the best of our knowledge, only five cases of extragingival PA have been reported. We present here a sixth case of extragingival PA of the buccal mucosa in an 80-year-old male. The tumor was surgically removed by blunt dissection and there is no evidence of recurrence for 7 months. We also discuss here the clinical characteristics, the origin, and the management of the tumor by reference to the relevant literature.

DOI： 10.1111/j.0904-2512.2006.00480.x

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記述言語：英語   出版者・発行元：CHROMA INC  

This study presents a comparative analysis of the open surgical and nonsurgical treatment of patients with bilateral condylar fractures. Sixty-seven (67) patients were treated, and the completed data on 55 patients were reviewed to compare both therapeutic modalities, which consisted of nonsurgical and surgical treatment in 37 and 18 patients, respectively. In the nonsurgical group, 23 patients (23/37, 62%) had normal mouth opening. Functional success rate was 79% (15/19) and 44% (8/18) in young adult patients (-29yrs) and older patients (30+yrs), respectively, and there was a significant difference of outcome between the two groups. In nonsurgically treated young patients with disorders, bilateral dislocation and existence of concomitant mandibular fractures were commonly observed. In the open surgical group, seven (7/11, 64%) young adult and three (3/7, 43%) older patients gained normal mouth opening, and no significant difference was observed. Additionally, there was no difference between non-surgical and surgical treatment in any category. Patients undergoing rigid fixation benefited from restoring maximum mouth opening, although there was no significant difference between the rigid and non-rigid fixation groups. Based on these findings, nonrigid fixation should be avoided, and rigid fixation might improve outcome in young adult patients with severe fracture pattern, such as bilateral dislocation and concomitant mandibular fracture.

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記述言語：英語   出版者・発行元：CHROMA INC  

This study presents a comparative analysis of the open surgical and nonsurgical treatment of patients with bilateral condylar fractures. Sixty-seven (67) patients were treated, and the completed data on 55 patients were reviewed to compare both therapeutic modalities, which consisted of nonsurgical and surgical treatment in 37 and 18 patients, respectively. In the nonsurgical group, 23 patients (23/37, 62%) had normal mouth opening. Functional success rate was 79% (15/19) and 44% (8/18) in young adult patients (-29yrs) and older patients (30+yrs), respectively, and there was a significant difference of outcome between the two groups. In nonsurgically treated young patients with disorders, bilateral dislocation and existence of concomitant mandibular fractures were commonly observed. In the open surgical group, seven (7/11, 64%) young adult and three (3/7, 43%) older patients gained normal mouth opening, and no significant difference was observed. Additionally, there was no difference between non-surgical and surgical treatment in any category. Patients undergoing rigid fixation benefited from restoring maximum mouth opening, although there was no significant difference between the rigid and non-rigid fixation groups. Based on these findings, nonrigid fixation should be avoided, and rigid fixation might improve outcome in young adult patients with severe fracture pattern, such as bilateral dislocation and concomitant mandibular fracture.

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DOI： 10.1097/01.prs.0000267435.17767.0a

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DOI： 10.11277/stomatology1952.56.9

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DOI： 10.1111/j.1600-0714.2007.00518.x

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記述言語：英語  

Because the submandibular gland is believed to have no intraparenchymal lymph nodes, preserving the submandibular gland for neck dissection and transferring the submandibular gland in order to prevent xerostomia induced by radiation therapy in patients with head and neck cancer have recently been described. We report a case of intraparenchymal metastasis in the submandibular gland 8 months after the initial intraoral excision of tongue cancer. This finding offers evidence that the submandibular gland includes intraparenchymal metastasis that can be involved with cancer. © 2006 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.ooe.2006.10.001

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記述言語：英語   出版者・発行元：AMER SOC NEURORADIOLOGY  

We report 2 cases of nasolabial cyst and a case of schwannoma beneath the alar base that required a differential diagnosis because of clinical features and MR images that resembled the nasolabial cyst. The morphologic analysis on MR images revealed the characteristic appearance of the nasolabial cyst, and the sagittal MR image may be most helpful for diagnosing this rare disease.

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記述言語：英語   出版者・発行元：BLACKWELL PUBLISHING  

We report a case of osseous dysplasia (OD) showing extremely rare clinical features. A 37-year-old Japanese woman was referred to our clinic complaining of a left alveolar bony swelling at an impacted canine. Radiographic examinations revealed a mixed radiopaque lesion involving the impacted left canine and also revealed an impacted left wisdom tooth with a cystic change and a clear radiopaque lesion suspected to be odontoma. All the extracted upper teeth and odontoma showed hypercementosis and the canine was fully involved in it. Histopathologically, they showed the same features and were diagnosed as OD. The findings of multiple OD from incompletely erupted teeth and odontoma in our case may well show that OD can arise from any tooth with periodontal ligaments and that focal OD can show expansive growth like the ossifying fibroma.

DOI： 10.1111/j.1600-0714.2006.00414.x

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記述言語：英語   出版者・発行元：CHURCHILL LIVINGSTONE  

Background: The frequent insertion of self-tapping screws for securing the proximal positioning plate in bimaxillary osteotomy often cause loosening of screws and plate, which produces incorrect repositioning. In this article, a newly developed base-attachment for a T-shaped proximal positioning plate for bimaxillary osteotomy is presented. Material: The base-attachment set consists of a titanium base-attachment and two titanium tapped screws. The attachment has a shallow depression having the same shape as the basal part of the positioning plate. Method: The base-attachment is secured by self-tapping screws until the end of the procedure, and the T-shaped proximal positioning plate is placed and secured by two titanium-tapped screws. Result: By using this base-attachment, the T-shaped plate can be easily placed repeatedly without difficulty. Conclusion: This base-attachment set may be useful for the frequently repositioned proximal plate in bimaxillary osteotomy. (C) 2006 European Association for Cranio-Maxillofacial Surgery.

DOI： 10.1016/j.jcms.2006.01.002

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記述言語：英語   出版者・発行元：CHURCHILL LIVINGSTONE  

Background: The frequent insertion of self-tapping screws for securing the proximal positioning plate in bimaxillary osteotomy often cause loosening of screws and plate, which produces incorrect repositioning. In this article, a newly developed base-attachment for a T-shaped proximal positioning plate for bimaxillary osteotomy is presented. Material: The base-attachment set consists of a titanium base-attachment and two titanium tapped screws. The attachment has a shallow depression having the same shape as the basal part of the positioning plate. Method: The base-attachment is secured by self-tapping screws until the end of the procedure, and the T-shaped proximal positioning plate is placed and secured by two titanium-tapped screws. Result: By using this base-attachment, the T-shaped plate can be easily placed repeatedly without difficulty. Conclusion: This base-attachment set may be useful for the frequently repositioned proximal plate in bimaxillary osteotomy. (C) 2006 European Association for Cranio-Maxillofacial Surgery.

DOI： 10.1016/j.jcms.2006.01.002

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記述言語：英語   出版者・発行元：QUINTESSENCE PUBLISHING CO INC  

In this article, a procedure involving 2-stage alveolar distraction osteogenesis using eccentric distraction devices for the augmentation of resorbed transplanted iliac bone following mandibular tumor resection is presented. A 6-month consolidation period was allowed between the first and second distractions, and endosseous implants were placed 4 months after the second distraction. Computerized tomographic images obtained before the implantation revealed that, 10 months after the first distraction, the bone generated still showed lower density compared with the basal bone, but the bone from both distractions showed enough maturity for implantation. It may be concluded that 2-stage alveolar distraction osteogenesis can be a useful and safe procedure for excessive alveolar lengthening if a sufficiently long consolidation period is allowed.

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記述言語：英語   出版者・発行元：QUINTESSENCE PUBLISHING CO INC  

In this article, a procedure involving 2-stage alveolar distraction osteogenesis using eccentric distraction devices for the augmentation of resorbed transplanted iliac bone following mandibular tumor resection is presented. A 6-month consolidation period was allowed between the first and second distractions, and endosseous implants were placed 4 months after the second distraction. Computerized tomographic images obtained before the implantation revealed that, 10 months after the first distraction, the bone generated still showed lower density compared with the basal bone, but the bone from both distractions showed enough maturity for implantation. It may be concluded that 2-stage alveolar distraction osteogenesis can be a useful and safe procedure for excessive alveolar lengthening if a sufficiently long consolidation period is allowed.

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

CiNii Article

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

CiNii Article

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

CiNii Article

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記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

CiNii Article

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記述言語：英語   出版者・発行元：MOSBY, INC  

Objective. This retrospective study examines the relationship between histopathologically diagnosed cases of in calcifying odontogenic cysts (COCs) on the adjacent dentition.
Study design. The records including diagnostic radiograph images of 11 patients treated for COCs from 1991 to 2004 were analyzed and correlations made between radiologic and histopathologic features. Special attention was applied to the associations between COCs and adjacent teeth.
Results. Radiologic and histopathologic features of the 11 lesions were variable, with some lesions being more solid and others more cystic. Calcifications varied from small flecks to solid calcified areas of frank odontoma. In 7 cases, the COC was associated with an impacted tooth and 5 of these cases involved COC-enveloping teeth. All cases excepting one in an edentulous jaw segment showed positional changes of adjacent teeth, including impaction.
Conclusions. The radiographical features of COCs are varied but there is a high frequency of changes in adjacent teeth, including dental impaction. The presence of impaction or displacement of teeth for COCs occurring in the posterior segments of the jaw, and absence of this finding for anteriorly placed lesions may be indicative of the timing of COC development.

DOI： 10.1016/j.tripleo.2005.08.037

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DOI： 10.1016/j.ooe.2006.10.001

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DOI： 10.1111/j.1600-0714.2006.00414.x

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記述言語：英語   出版者・発行元：CHURCHILL LIVINGSTONE  

ground: Several studies have shown the increased risk of mandibular angle fractures associated with incompletely erupted mandibular third molars. But only a few reports analysed in detail the relationship of the status of eruption of this tooth and this type of fracture. Objectives: The purpose of this study was to clarify the influence of the eruption status of incompletely erupted mandibular third molars on the incidence of mandibular angle fractures. Methods: Four hundred and thirty-six mandibular halves in 218 patients with mandibular fractures, aged between 15 and 40 years old, were analysed using panoramic radiographs. Results: The incidence of angle fractures in the mandibular halves with incompletely erupted mandibular third molars was 30.8% and this was statistically significantly higher than that in another group (p&LT; 0.0001). Deeply located mandibular third molars clearly showed a higher incidence of this fracture when compared with the adjacent second molar (p&LT; 0.0001). Conclusion: The results of this investigation showed that incompletely erupted mandibular third molars close to the inferior border of the mandible have a high risk of angle fractures. &COPY; 2005 European Association for Cranio-Maxillofacial Surgery.

DOI： 10.1016/j.jcms.2004.12.001

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記述言語：英語   出版者・発行元：CHURCHILL LIVINGSTONE  

ground: Several studies have shown the increased risk of mandibular angle fractures associated with incompletely erupted mandibular third molars. But only a few reports analysed in detail the relationship of the status of eruption of this tooth and this type of fracture. Objectives: The purpose of this study was to clarify the influence of the eruption status of incompletely erupted mandibular third molars on the incidence of mandibular angle fractures. Methods: Four hundred and thirty-six mandibular halves in 218 patients with mandibular fractures, aged between 15 and 40 years old, were analysed using panoramic radiographs. Results: The incidence of angle fractures in the mandibular halves with incompletely erupted mandibular third molars was 30.8% and this was statistically significantly higher than that in another group (p&LT; 0.0001). Deeply located mandibular third molars clearly showed a higher incidence of this fracture when compared with the adjacent second molar (p&LT; 0.0001). Conclusion: The results of this investigation showed that incompletely erupted mandibular third molars close to the inferior border of the mandible have a high risk of angle fractures. &COPY; 2005 European Association for Cranio-Maxillofacial Surgery.

DOI： 10.1016/j.jcms.2004.12.001

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記述言語：英語  

The cortical masticatory area (CMA) elicits rhythmic jaw movements in response to repetitive stimulation and is involved in the control of mastication. Based on jaw movement patterns, the CMA is divided into two parts. One is the part of the CMA in which a T-pattern similar to jaw movements during food transport in natural mastication is evoked by electrical stimulation. The other is more dorsomedially located, and during chewing a C-pattern similar to jaw movements can be induced. However, it is still not known which region of the putamen receives projections from the CMA and whether projections originate from both parts of the CMA. In this study, electrophysiological and histological experiments were undertaken in rabbits to investigate projections from the CMA to the putamen. Both experiments showed that the ventral region of the putamen received projections from the CMA. The density of the projections from the CMA area inducing the T-pattern seemed to be higher than that from the area inducing the C-pattern. Furthermore, the peak latency of the evoked potentials from stimulation of the CMA area inducing the T-pattern was shorter than that from stimulation of the area inducing the C-pattern. The data obtained from the present study indicate the functional role of the ventral region of the putamen in the regulation of mastication, and further suggest that the corticostriatal pathway is involved in the transition between behavioral jaw movement patterns. © Springer-Verlag 2004.

DOI： 10.1007/s00221-004-2073-0

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記述言語：英語  

The cortical masticatory area (CMA) elicits rhythmic jaw movements in response to repetitive stimulation and is involved in the control of mastication. Based on jaw movement patterns, the CMA is divided into two parts. One is the part of the CMA in which a T-pattern similar to jaw movements during food transport in natural mastication is evoked by electrical stimulation. The other is more dorsomedially located, and during chewing a C-pattern similar to jaw movements can be induced. However, it is still not known which region of the putamen receives projections from the CMA and whether projections originate from both parts of the CMA. In this study, electrophysiological and histological experiments were undertaken in rabbits to investigate projections from the CMA to the putamen. Both experiments showed that the ventral region of the putamen received projections from the CMA. The density of the projections from the CMA area inducing the T-pattern seemed to be higher than that from the area inducing the C-pattern. Furthermore, the peak latency of the evoked potentials from stimulation of the CMA area inducing the T-pattern was shorter than that from stimulation of the area inducing the C-pattern. The data obtained from the present study indicate the functional role of the ventral region of the putamen in the regulation of mastication, and further suggest that the corticostriatal pathway is involved in the transition between behavioral jaw movement patterns. © Springer-Verlag 2004.

DOI： 10.1007/s00221-004-2073-0

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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出版者・発行元：日本歯科理工学会  

顎変形症患者の骨切り手術では、２次元セファロ写真を元に上下顎骨の位置を予測し、手術における顎位の決定には、歯列模型上で製作したバイトスプリントを用いるのが一般的である。一方、我々は3次元顎骨CT像をVRハプティックデバイスで操作することで、骨切り術のシミュレーションを行ってきた。今回はシミュレーションにおいてCADし、RP法でCAM製作したバイトスプリントを顎位決定に用いた手術法を開発したので報告する。

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記述言語：英語   出版者・発行元：CHURCHILL LIVINGSTONE  

A maxillofacial simulator can support education and training. In the present study, cutting, separation, and quantitative rearrangement of bone during orthognathic surgery were simulated by means of a haptic device with virtual tactile perception. Computed tomographic (CT) images of two patients with severe jaw deformity, one women and one man, were input into the device. In the woman, Le Fort I osteotomy of the maxilla and sagittal splitting ramus osteotomy of the mandible were initially simulated. During surgery with the haptic device, separation and rearrangement of the maxilla and the ramus of the mandible were initially processed. However, there was discrepancy and overlapping of the ramus with the mandible. Intraoral vertical osteotomy of the right ramus was then performed, with satisfactory results and less discrepancy and interference. The simulation was referred to at surgery, and satisfactory surgical assistance was postoperatively confirmed on CT images. The male patient had severe jaw deformity due to unequal growth between the ramuses, resulting in anterior crossbite. Sagittal splitting ramus osteotomy with rotation of the mandible was successfully simulated. Because of its versatility and functions, the present device was found to be useful for simulating various procedures for orthognathic surgery and thereby three-dimensionally determine surgical movements.

DOI： 10.1016/j.ijom.2004.03.003

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記述言語：英語   出版者・発行元：CHURCHILL LIVINGSTONE  

A maxillofacial simulator can support education and training. In the present study, cutting, separation, and quantitative rearrangement of bone during orthognathic surgery were simulated by means of a haptic device with virtual tactile perception. Computed tomographic (CT) images of two patients with severe jaw deformity, one women and one man, were input into the device. In the woman, Le Fort I osteotomy of the maxilla and sagittal splitting ramus osteotomy of the mandible were initially simulated. During surgery with the haptic device, separation and rearrangement of the maxilla and the ramus of the mandible were initially processed. However, there was discrepancy and overlapping of the ramus with the mandible. Intraoral vertical osteotomy of the right ramus was then performed, with satisfactory results and less discrepancy and interference. The simulation was referred to at surgery, and satisfactory surgical assistance was postoperatively confirmed on CT images. The male patient had severe jaw deformity due to unequal growth between the ramuses, resulting in anterior crossbite. Sagittal splitting ramus osteotomy with rotation of the mandible was successfully simulated. Because of its versatility and functions, the present device was found to be useful for simulating various procedures for orthognathic surgery and thereby three-dimensionally determine surgical movements.

DOI： 10.1016/j.ijom.2004.03.003

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記述言語：英語  

Background: Several studies have shown an increased risk of mandibular angle fractures by the presence of the lower third molar (M3), especially the incompletely erupted M3. The presence of M3s might influence condylar fractures, which is one of the most common fracture sites, as well as the angle fracture. Methods: Six hundred ninety-two mandibular sides among 346 patients with mandibular fracture were analyzed. They were classified into two groups according to the presence of incompletely erupted M3s and were analyzed according to fracture site, age, and cause of injury. Results: Among these patients with mandibular fractures, the frequency of occurrence of the mandibular angle fracture was higher in the group with incompletely erupted M3s (p &lt
0.0001) and that of the condylar fracture was higher in the group without it (p &lt
0.001). Conclusion: The result of this retrospective investigation shows that an incompletely erupted M3 decreases the risk of condylar fractures and increases the risk of mandibular angle fractures.

DOI： 10.1097/01.TA.0000096647.36992.83

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記述言語：英語   出版者・発行元：CHURCHILL LIVINGSTONE  

Osteochondroma is a benign neoplasm that usually develops in long. bones and very rarely occurs in craniofacial bones. Nearly all reported mandibular osteochondromas have arisen in the condyle and the coronoid process, and occurrence in other locations is extremely rare. We describe a case of osteochondroma arising from the inferior border of the mandibular symphysis.

DOI： 10.1016/j.ijom.2003.10.010

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記述言語：英語   出版者・発行元：CHURCHILL LIVINGSTONE  

Osteochondroma is a benign neoplasm that usually develops in long. bones and very rarely occurs in craniofacial bones. Nearly all reported mandibular osteochondromas have arisen in the condyle and the coronoid process, and occurrence in other locations is extremely rare. We describe a case of osteochondroma arising from the inferior border of the mandibular symphysis.

DOI： 10.1016/j.ijom.2003.10.010

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記述言語：日本語   出版者・発行元：(公財)石本記念デサントスポーツ科学振興財団  

スポーツによって受傷した下顎骨骨折36例のパノラマX線写真をもとに,親知らず(下顎埋伏智歯)の存在が下顎角部骨折にどのような影響を及ぼしているのかを検討した.その結果,スポーツ外傷例は他の受傷例と同様に,埋伏智歯を保有する下顎角部での骨折頻度がほかの部位に比べて有意に高く,とくに次のようなケースで高いことが明らかになった.1)近心に傾斜し根尖が下顎角部方向に萠出する智歯.2)下顎角部が智歯によって広く占拠され同部のX線的骨面積が狭いもの

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記述言語：英語   出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD  

Cancer metastasis is not a random process and different cancer types have favorite metastatic sites. Recent studies on metastasis have focused on chemoattraction, particularly on the role of chemokines. Therefore, in this study we investigated whether CXCR4 (receptor for stromal cell-derived factor-1) is expressed in squamous cell carcinoma of the tongue. For this purpose, immunohistochemical staining was performed on 26 sections obtained from 23 patients (15 patients having tongue tumor without lymph node metastasis and eight patients having lymph node metastasis). All tumor cells expressed CXCR4, whereas normal mucosa of the tongue had no or faint expression CXCR4. Metastatic tumor cells in lymph nodes had stronger expression than primary tongue tumor cells. Our data raises the possibility that CXCR4 could be involved in lymph node metastasis of oral squamous cell carcinoma. (C) 2003 Elsevier Ltd. All rights reserved.

DOI： 10.1016/S1368-8375(03)00144-1

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記述言語：英語   出版者・発行元：MOSBY, INC  

Objective. The aim of this study was to investigate the incidence and type of maxillofacial fractures caused by various sports played with a ball to better understand the nature of these fractures.
Study design. Retrospective study was carried out using records from 100 patients treated between 1986-2002. Age and sex, etiology, and site of the fracture, yearly and monthly distribution of the fractures, and treatment modality were analyzed.
Results. The fractures mostly resulted from baseball (44%), followed by rugby (28%) and soccer (18%). The highest incidence was in the 10- to 19-year age-group with male propensity. The most common cause of the fractures was impact against another player (43%). The majority of the patients suffered from mandibular fractures (56%), followed by midface (31%) and alveolar fractures (12%). Mandibular angle, zygoma, and zygomatic arch fractures were prominent for rugby fractures. A yearly comparison of the fracture incidence showed a gradual decrease over the 16-year period. Fractures had a peak incidence in autumn. 55% of the patients were treated surgically. Surgical intervention was mostly needed for patients sustaining fractures during soccer (72.2%).
Conclusions. Among ball-related sports, baseball is responsible for most of the maxillofacial fractures, but, although the incidence is not that high, soccer-related fractures may be more severe due to the nature of this sport.

DOI： 10.1016/j.tripleo.2003.10.008

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記述言語：英語   出版者・発行元：MOSBY, INC  

Objective. The aim of this study was to investigate the incidence and type of maxillofacial fractures caused by various sports played with a ball to better understand the nature of these fractures.
Study design. Retrospective study was carried out using records from 100 patients treated between 1986-2002. Age and sex, etiology, and site of the fracture, yearly and monthly distribution of the fractures, and treatment modality were analyzed.
Results. The fractures mostly resulted from baseball (44%), followed by rugby (28%) and soccer (18%). The highest incidence was in the 10- to 19-year age-group with male propensity. The most common cause of the fractures was impact against another player (43%). The majority of the patients suffered from mandibular fractures (56%), followed by midface (31%) and alveolar fractures (12%). Mandibular angle, zygoma, and zygomatic arch fractures were prominent for rugby fractures. A yearly comparison of the fracture incidence showed a gradual decrease over the 16-year period. Fractures had a peak incidence in autumn. 55% of the patients were treated surgically. Surgical intervention was mostly needed for patients sustaining fractures during soccer (72.2%).
Conclusions. Among ball-related sports, baseball is responsible for most of the maxillofacial fractures, but, although the incidence is not that high, soccer-related fractures may be more severe due to the nature of this sport.

DOI： 10.1016/j.tripleo.2003.10.008

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DOI： 10.1097/01.TA.0000096647.36992.83

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DOI： 10.5794/jjoms.50.227

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記述言語：英語   出版者・発行元：CHURCHILL LIVINGSTONE  

Objective: This study was performed to clarify the characteristics of facial fractures caused by falls with a particular focus on aetiology. Patients: Of 505 patients with facial fractures treated in the Department of Oral and Maxillofacial/Craniofacial Surgery, Heidelberg University Hospital from January 1997 to May 2001, 129 patients injured by falls were analysed. Study design: Aetiological analysis was performed according to falling patterns. Results: The distribution of age showed two peaks in the 4th and 8th decades, and the male to female ratio was 1.1:1, unlike the overall facial fracture ratio of 3:1. Seventy-six patients had fallen from standing height or less and 44 patients had fallen from greater heights. The former cases were more often seen in older females. More severe injuries tend to be seen in the patients who have fallen from greater heights, and in the cases associated with acute medical disorders. Conclusion: This retrospective study documents the higher risk of fractures in older females and the higher risk of severe injury in those patients who were unconscious. This is in agreement with recent orthopaedic studies. (C) 2003 European Association for Cranio-Maxillofacial Surgery.

DOI： 10.1016/S1010-5182(03)00069-6

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記述言語：英語   出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS  

To correct the nasal deformity in cleft lip patients, a new procedure of open rhinoplasty using a "flying-bird" incision in the nostril tip with a vestibule "tornado" shaped incision in the cleft side is presented. The newly designed vestibular incision produces effective vestibular advancement with the freed lower lateral cartilage. The flying-bird incision makes it possible to produce a suitable nostril tip appearance with symmetrical external nostril vestibules. If the vestibular defect after flap advancement is wide, a full-thickness skin graft is used to give priority for making a good external nostril shape. This procedure is useful for most cleft lip noses, particularly in cases of moderate to severe deformity.

DOI： 10.1097/01.PRS.0000070723.17041.4D

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記述言語：英語   出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS  

To correct the nasal deformity in cleft lip patients, a new procedure of open rhinoplasty using a "flying-bird" incision in the nostril tip with a vestibule "tornado" shaped incision in the cleft side is presented. The newly designed vestibular incision produces effective vestibular advancement with the freed lower lateral cartilage. The flying-bird incision makes it possible to produce a suitable nostril tip appearance with symmetrical external nostril vestibules. If the vestibular defect after flap advancement is wide, a full-thickness skin graft is used to give priority for making a good external nostril shape. This procedure is useful for most cleft lip noses, particularly in cases of moderate to severe deformity.

DOI： 10.1097/01.PRS.0000070723.17041.4D

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記述言語：英語   出版者・発行元：ALLIANCE COMMUNICATIONS GROUP DIVISION ALLEN PRESS  

Objective: To analyze the effects of airflow in the larynx on activity of the levator veli palatini and pterygopharyngeal muscles.
Design: Ten adult beagle dogs were anesthetized with sodium pentobarbital. In each dog, two tracheal tubes were inserted subsequent to tracheotomy, one in the direction of the vocal folds and the other toward the lungs for respiration. In the first of three experiments, the effect of artificial airflow on electromyographic activity of the levator and pterygopharyngeal muscles was studied. In the second experiment, the effect of air pressure beneath the vocal folds on the activity of these muscles was studied. For the third experiment, the larynx was isolated surgically without cutting the bilateral superior laryngeal nerves and the effect of airflow through it examined.
Results and Conclusion: Both outward airflow and higher pressure enhanced expiratory activity of the levator and pterygopharyngeal muscles. Receptors in the subglottal area play major roles in this enhancement. Furthermore, an increase in air pressure during expiration enhances closure of the velopharynx.

DOI： 10.1597/1545-1569(2003)040<0351:EOSAPO>2.0.CO;2

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記述言語：英語   出版者・発行元：ALLIANCE COMMUNICATIONS GROUP DIVISION ALLEN PRESS  

Objective: To analyze the effects of airflow in the larynx on activity of the levator veli palatini and pterygopharyngeal muscles.
Design: Ten adult beagle dogs were anesthetized with sodium pentobarbital. In each dog, two tracheal tubes were inserted subsequent to tracheotomy, one in the direction of the vocal folds and the other toward the lungs for respiration. In the first of three experiments, the effect of artificial airflow on electromyographic activity of the levator and pterygopharyngeal muscles was studied. In the second experiment, the effect of air pressure beneath the vocal folds on the activity of these muscles was studied. For the third experiment, the larynx was isolated surgically without cutting the bilateral superior laryngeal nerves and the effect of airflow through it examined.
Results and Conclusion: Both outward airflow and higher pressure enhanced expiratory activity of the levator and pterygopharyngeal muscles. Receptors in the subglottal area play major roles in this enhancement. Furthermore, an increase in air pressure during expiration enhances closure of the velopharynx.

DOI： 10.1597/1545-1569(2003)040<0351:EOSAPO>2.0.CO;2

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記述言語：英語   出版者・発行元：ALLIANCE COMMUNICATIONS GROUP DIVISION ALLEN PRESS  

Objective: To analyze the effects of airflow in the larynx on activity of the levator veli palatini and pterygopharyngeal muscles.
Design: Ten adult beagle dogs were anesthetized with sodium pentobarbital. In each dog, two tracheal tubes were inserted subsequent to tracheotomy, one in the direction of the vocal folds and the other toward the lungs for respiration. In the first of three experiments, the effect of artificial airflow on electromyographic activity of the levator and pterygopharyngeal muscles was studied. In the second experiment, the effect of air pressure beneath the vocal folds on the activity of these muscles was studied. For the third experiment, the larynx was isolated surgically without cutting the bilateral superior laryngeal nerves and the effect of airflow through it examined.
Results and Conclusion: Both outward airflow and higher pressure enhanced expiratory activity of the levator and pterygopharyngeal muscles. Receptors in the subglottal area play major roles in this enhancement. Furthermore, an increase in air pressure during expiration enhances closure of the velopharynx.

DOI： 10.1597/1545-1569(2003)040<0351:EOSAPO>2.0.CO;2

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記述言語：英語  

To clarify the aspects and role of oropharyngeal closure, soft palate movements during sucking were observed and then assessed by electromyographic and fluoroscopic analyses. Three patterns of sucking movements by the palatoglossus and levator veli palatini muscles were analyzed with electromyographic means in seven healthy adults. Furthermore, a forced sucking maneuver, which required special effort to produce a strong sucking pressure by opening the jaw, was analyzed using lateral fluoroscopy in three of the subjects. During all tested sucking movements, the palatoglossus muscle showed continuous activity. The levator veli palatini muscle did not show remarkable activity during regular air sucking or water sucking when water was held in the oral cavity. However, its participation increased when intraoral sucking pressure was increased by opening the jaw, and lateral fluoroscopic examinations revealed that the soft palate was pulled toward the oral cavity to form a tight contact between the rostral portion of the soft palate and the retrotongue, causing the soft palate to make an "L" shape. The palatoglossus muscle plays a major role in palatal movement during sucking. Furthermore, the levator veli palatini muscle, whose activity was observed only during high-pressure sucking with an open jaw, may act to maintain tension in the soft palate against strong negative pressure in the oral cavity.

DOI： 10.1007/s00455-002-0090-3

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記述言語：英語  

To clarify the aspects and role of oropharyngeal closure, soft palate movements during sucking were observed and then assessed by electromyographic and fluoroscopic analyses. Three patterns of sucking movements by the palatoglossus and levator veli palatini muscles were analyzed with electromyographic means in seven healthy adults. Furthermore, a forced sucking maneuver, which required special effort to produce a strong sucking pressure by opening the jaw, was analyzed using lateral fluoroscopy in three of the subjects. During all tested sucking movements, the palatoglossus muscle showed continuous activity. The levator veli palatini muscle did not show remarkable activity during regular air sucking or water sucking when water was held in the oral cavity. However, its participation increased when intraoral sucking pressure was increased by opening the jaw, and lateral fluoroscopic examinations revealed that the soft palate was pulled toward the oral cavity to form a tight contact between the rostral portion of the soft palate and the retrotongue, causing the soft palate to make an "L" shape. The palatoglossus muscle plays a major role in palatal movement during sucking. Furthermore, the levator veli palatini muscle, whose activity was observed only during high-pressure sucking with an open jaw, may act to maintain tension in the soft palate against strong negative pressure in the oral cavity.

DOI： 10.1007/s00455-002-0090-3

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記述言語：英語  

To clarify the aspects and role of oropharyngeal closure, soft palate movements during sucking were observed and then assessed by electromyographic and fluoroscopic analyses. Three patterns of sucking movements by the palatoglossus and levator veli palatini muscles were analyzed with electromyographic means in seven healthy adults. Furthermore, a forced sucking maneuver, which required special effort to produce a strong sucking pressure by opening the jaw, was analyzed using lateral fluoroscopy in three of the subjects. During all tested sucking movements, the palatoglossus muscle showed continuous activity. The levator veli palatini muscle did not show remarkable activity during regular air sucking or water sucking when water was held in the oral cavity. However, its participation increased when intraoral sucking pressure was increased by opening the jaw, and lateral fluoroscopic examinations revealed that the soft palate was pulled toward the oral cavity to form a tight contact between the rostral portion of the soft palate and the retrotongue, causing the soft palate to make an "L" shape. The palatoglossus muscle plays a major role in palatal movement during sucking. Furthermore, the levator veli palatini muscle, whose activity was observed only during high-pressure sucking with an open jaw, may act to maintain tension in the soft palate against strong negative pressure in the oral cavity.

DOI： 10.1007/s00455-002-0090-3

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DOI： 10.1597/1545-1569(2003)040<0351:EOSAPO>2.0.CO;2

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DOI： 10.1097/01.PRS.0000070723.17041.4D

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DOI： 10.1597/1545-1569(2003)040<0351:EOSAPO>2.0.CO;2

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出版者・発行元：日本歯科理工学会  

前回，VRハプティックデバイスを用いた顎変形症の外科矯正手術シミュレーションを試み報告した．3次元CT像に対しこのデバイスを操作することで，骨切開，分離，移動，接合のプロセスを進めることができた．今回は，臨床における下顎骨切りの術式である，下顎矢状分割術や口腔内下顎枝垂直分割術等，種々の術式に対するシミュレーションと，その際の骨の移動と回転量の比較，および最適術式についての検討を試みたので報告する．

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記述言語：日本語   出版者・発行元：(公社)日本口腔外科学会  

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記述言語：英語  

DOI： 10.1053/joms.2002.35033

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記述言語：英語  

DOI： 10.1053/joms.2002.35033

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記述言語：英語   出版者・発行元：W B SAUNDERS CO  

DOI： 10.1053/joms.2002.35033

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記述言語：英語  

DOI： 10.1054/jcms.2002.0295

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記述言語：英語   出版者・発行元：CHURCHILL LIVINGSTONE  

Objective: Paediatric maxillofacial fractures are not common and carry different clinical features when compared with adults. To clarify the differences of aetiology and patterns of fractures in paediatric patients, a clinical retrospective analysis was performed. Patients: One hundred seventy-four paediatric patients younger than 16 years of age treated in the First Department of Oral and Maxillofacial Surgery, Osaka University Dental Hospital during a 15-year period were analysed. Study design: Age, sex, fracture patterns, incidence, common locations of the mandibular fractures and treatment were studied according to the patients' charts and radiographs. Results: The ratio of boys to girls was 2: 1 and the largest age subgroup was 15-years old. The most common cause of injury was bicycle accidents (26%), followed by falls (25%). The distribution of causes and ages revealed that the incidence of the fall-related injuries decreased in patients older than 10 years, and assaults became a common cause in patients older than 12 years. The yearly distribution showed a decrease of the group between 6 and 10 years and of bicycle-related accidents in the last 5-year period (1992-1996). Mandibular fractures were most common (56%), followed by fractures of the alveolar process (31%). Condylar fracture was common in children younger than 14 years, especially in those below 6 years. Fractures of the mandibular angle were the most common in those above 13 years. Conclusion: These results document that the aetiological characters and patterns of paediatric maxillofacial fractures gradually shifted towards those found in adolescents. (C) 2002 European Association for Cranio-Maxillofacial Surgery. Published by Elsevier Science Ltd. All rights reserved

DOI： 10.1054/jcms.2002.0295

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記述言語：英語   出版者・発行元：Churchill Livingstone  

Objective: Paediatric maxillofacial fractures are not common and carry different clinical features when compared with adults. To clarify the differences of aetiology and patterns of fractures in paediatric patients, a clinical retrospective analysis was performed. Patients: One hundred seventy-four paediatric patients younger than 16 years of age treated in the First Department of Oral and Maxillofacial Surgery, Osaka University Dental Hospital during a 15-year period were analysed. Study design: Age, sex, fracture patterns, incidence, common locations of the mandibular fractures and treatment were studied according to the patients' charts and radiographs. Results: The ratio of boys to girls was 2:1 and the largest age subgroup was 15-years old. The most common cause of injury was bicycle accidents (26%), followed by falls (25%). The distribution of causes and ages revealed that the incidence of the fall-related injuries decreased in patients older than 10 years, and assaults became a common cause in patients older than 12 years. The yearly distribution showed a decrease of the group between 6 and 10 years and of bicycle-related accidents in the last 5-year period (1992-1996). Mandibular fractures were most common (56%), followed by fractures of the alveolar process (31%). Condylar fracture was common in children younger than 14 years, especially in those below 6 years. Fractures of the mandibular angle were the most common in those above 13 years. Conclusion: These results document that the aetiological characters and patterns of paediatric maxillofacial fractures gradually shifted towards those found in adolescents. © 2002 European Association for Cranio-Maxillofacial Surgery. Published by Elsevier Science Ltd. All rights reserved.

DOI： 10.1054/jcms.2002.0295

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DOI： 10.1054/jcms.2002.0295

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DOI： 10.1053/joms.2002.35033

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記述言語：英語   出版者・発行元：CHURCHILL LIVINGSTONE  

A total of 1502 patients with facial fractures treated between 1981 and 1996 were retrospectively analysed. The male: female ratio was 2.8:1 and the largest subgroup of patients was between 10 and 29 years of age. The most common cause of injury was traffic accidents (52%) involving motorcycles, bicycles or automobiles. Other common causes included, in descending order, falls (16.6%), assaults (15.5%) and sports (9.7%). Isolated mandibular fractures were most common (56.9%), followed by isolated midface fractures (25.9%). The percentage of fractures involving both the midface and mandible was 6.7, and that of isolated alveolar fractures was 10.5.

DOI： 10.1054/ijom.2001.0056

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記述言語：英語   出版者・発行元：CHURCHILL LIVINGSTONE  

Mucous cysts in the submandibular region-so-called 'plunging' ranula-are relatively uncommon. We report a case of a plunging ranula that complicated excision of an intraductal sialolith of the submandibular gland. (C) 2001 The British Association of Oral and Maxillofacial Surgeons.

DOI： 10.1054/bjom.2001.0621

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記述言語：英語   出版者・発行元：CHURCHILL LIVINGSTONE  

Mucous cysts in the submandibular region-so-called 'plunging' ranula-are relatively uncommon. We report a case of a plunging ranula that complicated excision of an intraductal sialolith of the submandibular gland. (C) 2001 The British Association of Oral and Maxillofacial Surgeons.

DOI： 10.1054/bjom.2001.0621

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DOI： 10.1054/ijom.2001.0056

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DOI： 10.5794/jjoms.47.447

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DOI： 10.1054/ijom.2001.0056

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記述言語：英語   出版者・発行元：Blackwell Munksgaard  

A total of 1502 patients with facial fractures treated between 1981 and 1996 were retrospectively analysed. The male: female ratio was 2.8:1 and the largest subgroup of patients was between 10 and 29 years of age. The most common cause of injury was traffic accidents (52%) involving motorcycles, bicycles or automobiles. Other common causes included, in descending order, falls (16.6%), assaults (15.5%) and sports (9.7%). Isolated mandibular fractures were most common (56.9%), followed by isolated midface fractures (25.9%). The percentage of fractures involving both the midface and mandible was 6.7, and that of isolated alveolar fractures was 10.5.

DOI： 10.1054/ijom.2001.0056

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記述言語：英語   出版者・発行元：MUNKSGAARD INT PUBL LTD  

This article reports a rare case of a displaced dental implant that migrated into the maxillary sinus.

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記述言語：英語   出版者・発行元：MUNKSGAARD INT PUBL LTD  

This article reports a rare case of a displaced dental implant that migrated into the maxillary sinus.

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記述言語：英語   出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD  

N-methyl-D,L-aspartate acid and bicuculline are required to enhance the trigeminal rhythmic activities in an in vitro isolated brainstem block preparation. In this study, we analyzed the effect of norepinephrine on the trigeminal neural circuit underlying rhythmic jaw movements. Rhythmic trigeminal activity is observed in brainstem preparations (inferior colliculus to obex) only following blockade of cu,adrenoceptors with idazoxan. This observation, combined with the inhibition of rhythm by alpha (2)-adrenoceptor agonists suggests endogenous alpha (2)-adrenoceptor mediated inhibition of trigeminal networks. A complex noradrenergic modulation of trigeminal systems is further supported by the prazosinsensitive potentiation of rhythm by bath application of the alpha (1)-adrenoceptor agonist phenylephrine. (C) 2000 Elsevier Science Inc.

DOI： 10.1016/S0361-9230(00)00322-1

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記述言語：英語  

DOI： 10.1016/S0361-9230(00)00322-1

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記述言語：英語  

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記述言語：英語   出版者・発行元：AMER CLEFT PALATE-CRANIOFACIAL ASSOC  

Objective: Respiratory-related electromyographic (EMG) activity of the superior pharyngeal constrictor (SPC) muscle was analyzed during the early stage of forced breathing.
Design: Four adult dogs anesthetized with sodium pentobarbital were used. In the first part of the study, oral and nasal breathing tubes were placed into the respective cavities, and a tracheotomy tube was placed in the second part of the study. Two conditions, the presence (oral-nasal tube breathing) and absence (tracheotomy breathing) of airflow in the upper airway, were achieved in each dog. Following quiet breathing, animals were connected to a closed breathing system, first by an oral-nasal tube and then by a tracheotomy tube. We proposed to induce a forced breathing condition mechanically by using this system for 1 minute. We increased resistance to airflow during forced breathing by means of connecting tubes and a bag. Our aim was not to produce chemical drive but to produce a forced respiration by increasing the resistance to airflow. Tidal volume, breathing frequency, minute volume, chest wall movement, and EMG activity of the SPC muscle were measured and analyzed.
Results: During quiet breathing through an oral-nasal or tracheotomy tube, low-amplitude EMG activity of the SPC muscle corresponding to the expiratory cycle of the respiration was observed. In both study conditions, phasic expiratory EMG activity increased immediately after the advent of the breathing from the closed system. Tidal volumes and frequencies also increased rapidly during forced breathing.
Conclusions: An increase in the resistance to airflow increased the activity of the SPC muscle. This augmented respiratory activity probably assists the patency of the upper airway. The augmented respiratory activity was independent of the local reflex pathways. Respiratory-related activity of the SPC muscle may help dilate and stiffen the pharyngeal airway, promoting airway patency.

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記述言語：英語   掲載種別：速報，短報，研究ノート等（学術雑誌）   出版者・発行元：MUNKSGAARD INT PUBL LTD  

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記述言語：英語   掲載種別：速報，短報，研究ノート等（学術雑誌）   出版者・発行元：MUNKSGAARD INT PUBL LTD  

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記述言語：英語   出版者・発行元：MUNKSGAARD INT PUBL LTD  

This study showed the influence of the push-back operation on the occurrence of sleep-related apnea in cleft-palate patients with an analysis of arterial oxygen saturation (SpO(2)) during sleep, polygraphic analysis of nasal air flow, and chest wall movements. The postoperative SpO(2) was lower than that of the presurgical period in all cases, requiring from five to nine days to recover to presurgical levels. According to polygraphic analysis this depression of SpO(2) was caused by peripheral obstructive apnea, while, in spite of the cessation of nasal airflow, chest wall movement continued.

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記述言語：英語   出版者・発行元：MUNKSGAARD INT PUBL LTD  

This study showed the influence of the push-back operation on the occurrence of sleep-related apnea in cleft-palate patients with an analysis of arterial oxygen saturation (SpO(2)) during sleep, polygraphic analysis of nasal air flow, and chest wall movements. The postoperative SpO(2) was lower than that of the presurgical period in all cases, requiring from five to nine days to recover to presurgical levels. According to polygraphic analysis this depression of SpO(2) was caused by peripheral obstructive apnea, while, in spite of the cessation of nasal airflow, chest wall movement continued.

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記述言語：英語   出版者・発行元：AMER CLEFT PALATE-CRANIOFACIAL ASSOC  

Objective: The mechanical contraction property of the superior pharyngeal constrictor (PC) muscle was analyzed and compared with the levator veli palatini (LVP) muscle.
Design: Twenty adult dogs anesthetized with sodium pentobarbital were used.
Results: The isometric contraction curves of LVP and PC were recorded after direct electric stimulation to each muscle. The contraction time of isometric twitch contraction of the superior PC muscles was 30.3 +/- 5.25 msec, and the half relaxation time was 22.97 +/- 5.44 msec, The summation curve was observed at a stimulus frequency above 20 Hz of a repetitive pulse stimulus frequency of 85 Hz,
Conclusions: The mechanical contraction properties of the PC muscle are similar to those of the LVP, but with more aspects that are characteristic of a fast twitch muscle.

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記述言語：英語  

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DOI： 10.5794/jjoms.44.412

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DOI： 10.5794/jjoms.44.805

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記述言語：英語   出版者・発行元：AMER ASSOC DENTAL RESEARCH  

The levator veli palatini (LVP) and superior pharyngeal constrictor muscles (PC) close the velopharynx. However, for the velopharyngeal movements to be understood in detail, each muscle contraction must be analyzed precisely. This study was performed to clarify the velopharyngeal movement which was induced by a single muscle contraction, LVP or PC. Using a nasopharyngeal fiberscope, we analyzed the velopharyngeal movement associated with the contraction of the LVP and PC muscles in mongrel dogs. To elicit the maximal contraction of each muscle, we applied repetitive electrical stimulation to each peripheral nerve efferent to the LVP or PC muscle. Stimulation with a frequency of 77 Hz and 83 Hz induced maximal tension in the LVP and PC muscles, respectively, in isometric contraction. In a second series of experiments, fiberscopic views of the velopharyngeal movements associated with each muscle's maximal contraction were recorded. The degree of closure was calculated at several sections. The LVP muscle pulled the caudal fourth of the soft palate, while the PC projected the posterior wall at the level of the caudal end of the soft palate. The PC muscle also projected the lateral wall of the velopharynx. The effect of LVP contraction on the lateral wall was very small. These results show that the velopharyngeal movement associated with LVP contraction is very different from that with PC contraction.

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記述言語：英語  

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記述言語：英語   出版者・発行元：DECKER PERIODICALS INC  

Objective: This study, using mongrel dogs, attempted to delineate the respiratory activity of two closure muscles of the velopharynx, the levator veli palatini (LVP) and superior pharyngeal constrictor (PC) muscles.
Method: Fifteen mongrel dogs were given tracheotomies, with intratracheal tubes being connected to their respiratory circuits, Activities of the PC and LVP muscles were recorded electromyographically, and the effects of Pao(2) and Paco(2) were analyzed along with the effects of lung inflation intratracheally with O-2 and N-2.
Results: Under hypoxic conditions, expiratory LVP activity was observed while PC activity diminished. The effects of lung inflation on both LVP and PC activities were also studied, The activities of both muscles were enhanced by lung inflation,.
Conclusion: It was thus suggested that the roles of both muscles during velopharyngeal closing movements are not the same.

DOI： 10.1597/1545-1569(1997)034<0337:AOSPCA>2.3.CO;2

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記述言語：英語   出版者・発行元：DECKER PERIODICALS INC  

Objective: Oral-cavity feeding movements were analyzed during sucking and used to modify a Hotz-type plate to facilitate sucking in infants with cleft lip and palate.
Design: Sucking movements were analyzed using lateral view cine radiography as three adults fed from a bottle. A Hotz-type plate was then modified to better isolate the oral cavity and to occlude the oral airway,The plate was then utilized in direct breast feeding by 10 babies.
Outcome measures: Sucking rate, amount of milk taken, and duration of use of the plate were assessed.
Results: Wearing this plate, four babies with cleft lip and palate could suck their mother's breast, drinking about 22 g/trial.
Conclusions: Although supplemental bottle feeding was required to provide enough nourishment, this is the first step to reaching ideal breast feeding situation for these patients.

DOI： 10.1597/1545-1569(1997)034<0350:BFFCLA>2.3.CO;2

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記述言語：英語  

DOI： 10.1597/1545-1569(1997)034<0337:AOSPCA>2.3.CO;2

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DOI： 10.5794/jjoms.43.373

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DOI： 10.1597/1545-1569(1997)034<0350:BFFCLA>2.3.CO;2

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DOI： 10.11277/stomatology1952.46.187

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DOI： 10.5794/jjoms.43.927

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DOI： 10.11277/stomatology1952.46.393

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DOI： 10.5794/jjoms.42.693

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DOI： 10.11224/cleftpalate1976.21.3_150

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DOI： 10.5794/jjoms.42.320

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DOI： 10.5794/jjoms.42.457

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DOI： 10.11277/stomatology1952.45.67

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DOI： 10.5794/jjoms.41.890

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DOI： 10.5794/jjoms.41.263

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DOI： 10.5794/jjoms.40.1290

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DOI： 10.5794/jjoms.40.209

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DOI： 10.5794/jjoms.38.818

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DOI： 10.5794/jjoms.38.1919

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