Language：Japanese   Publisher：東京臨床出版(株)  

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Language：English   Publishing type：Research paper (scientific journal)  

Displacement of dental implants into the maxillary sinus is one of the common dental complications. However, it is rare that dental implants cause the displacement of multiple components due to separation. Here, we describe an unusual case of a 43-year-old man who had a missing implant in the maxillary sinus after an implant procedure. There was a two-week waiting period before we performed the removal during which the cap had unexpectedly separated from the body and freely moved into the ostium by sinus activity. The body was independently extracted intraorally. The remaining cap was secondly removed by utilizing nasal endoscopy. There were no complications in the postoperative period and the patient reported no symptoms of sinusitis after two months of follow-up. We experience unexpected events in the course of treating a displaced implant into the maxillary sinus. Our case report may provide several learning points for the removal of a missing implant.

DOI： 10.7759/cureus.63243

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Language：English   Publishing type：Research paper (scientific journal)  

Because cancer cells have a genetically unstable nature, they give rise to genetically different variant subclones inside a single tumor. Understanding cancer heterogeneity and subclone characteristics is crucial for developing more efficacious therapies. Oral squamous cell carcinoma (OSCC) is characterized by high heterogeneity and plasticity. On the other hand, CX3C motif ligand 1 (CX3CL1) is a double-faced chemokine with anti- and pro-tumor functions. Our study reported that CX3CL1 functioned differently in tumors with different cancer phenotypes, both in vivo and in vitro. Mouse OSCC 1 (MOC1) and MOC2 cells responded similarly to CX3CL1 in vitro. However, in vivo, CX3CL1 increased keratinization in indolent MOC1 cancer, while CX3CL1 promoted cervical lymphatic metastasis in aggressive MOC2 cancer. These outcomes were due to double-faced CX3CL1 effects on different immune microenvironments indolent and aggressive cancer created. Furthermore, we established that CX3CL1 promoted cancer metastasis via the lymphatic pathway by stimulating lymphangiogenesis and transendothelial migration of lymph-circulating tumor cells. CX3CL1 enrichment in lymphatic metastasis tissues was observed in aggressive murine and human cell lines. OSCC patient samples with CX3CL1 enrichment exhibited a strong correlation with lower overall survival rates and higher recurrence and distant metastasis rates. In conclusion, CX3CL1 is a pivotal factor that stimulates the metastasis of aggressive cancer subclones within the heterogeneous tumors to metastasize, and our study demonstrates the prognostic value of CX3CL1 enrichment in long-term monitoring in OSCC.

DOI： 10.1172/jci.insight.174618

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Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.heliyon.2024.e29445

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Publishing type：Research paper (scientific journal)   Publisher：SAGE Publications  

Neural crest cells (NCC) arise from the dorsal margin of the neural plate border and comprise a unique cell population that migrates to and creates the craniofacial region. Although factors including Shh, Fgf8, and bone morphogenetic proteins have been shown to regulate these biological events, the role of parathyroid hormone 1 receptor (Pth1r) has been less studied. We generated an NCC-specific mouse model for Pth1r and researched gene expression, function, and interaction focusing on nasal cartilage framework and midfacial development. Wnt1-Cre;Pth1r ^{fl/ fl}; Tomato ^fl/+ mice had perinatal lethality, but we observed short snout and jaws, tongue protrusion, reduced NCC-derived cranial length, increased mineralization in nasal septum and hyoid bones, and less bone mineralization at interfrontal suture in mutants at E18.5. Importantly, the mutant nasal septum and turbinate cartilage histologically revealed gradual, premature accelerated hypertrophic differentiation. We then studied the underlying molecular mechanisms by performing RNA seq analysis and unexpectedly found that expression of Ihh and related signaling molecules was enhanced in mutant nasomaxillary tissues. To see if Pth1r and Ihh signaling are associated, we generated a Wnt1-Cre; Ihh ^{fl/ fl}; Pth1r ^{fl/ fl}; Tomato ^fl/+ (DKO) mouse and compared the phenotypes to those of each single knockout mouse: Wnt1-Cre; Ihh ^{fl/ fl}; Pth1r ^fl/+; Tomato ^fl/+ (Ihh-CKO) and Wnt1-Cre;Ihh ^fl/+; Pth1r ^{fl/ fl}; Tomato ^fl/+ (Pth1r-CKO). Ihh-CKO mice displayed a milder effect. Of note, the excessive hypertrophic conversion of the nasal cartilage framework observed in Pth1r-CKO was somewhat rescued DKO embryos. Further, a half cAMP responsive element and the 4 similar sequences containing 2 mismatches were identified from the promoter to the first intron in Ihh gene. Gli1-Cre ^ERT2; Pth1r ^{fl/ fl}; Tomato ^fl/+, a Pth1r-deficient model targeted in hedgehog responsive cells, demonstrated the enlarged hypertrophic layer and significantly more Tomato-positive chondrocytes accumulated in the nasal septum and ethmoidal endochondral ossification. Collectively, the data suggest a relevant Pth1r/Ihh interaction. Our findings obtained from novel mouse models for Pth1r signaling illuminate previously unknown aspects in craniofacial biology and development.

DOI： 10.1177/00220345231221954

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Other Link： http://journals.sagepub.com/doi/full-xml/10.1177/00220345231221954

Language：Japanese   Publisher：岡山歯学会  

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Authorship：Last author   Language：Japanese  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J01073&link_issn=&doc_id=20231027410005&doc_link_id=10.5794%2Fjjoms.69.475&url=https%3A%2F%2Fdoi.org%2F10.5794%2Fjjoms.69.475&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Publishing type：Research paper (scientific journal)  

DOI： 10.1177/00220345231184405

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Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

Abstract

Cellular communication network factor 2 (CCN2) molecules promote endochondral ossification and articular cartilage regeneration, and circular RNAs (circRNAs), which arise from various genes and regulate gene expression by adsorbing miRNAs, are known to be synthesized from CCN2 in human vascular endothelial cells and other types of cells. However, in chondrocytes, not only the function but also the presence of CCN2-derived circRNA remains completely unknown. In the present study, we investigated the expression and function of CCN2-derived circRNAs in chondrocytes. Amplicons smaller than those from known CCN2-derived circRNAs were observed using RT-PCR analysis that could specifically amplify CCN2-derived circRNAs in human chondrocytic HCS-2/8 cells. The nucleotide sequences of the PCR products indicated novel circRNAs in the HCS-2/8 cells that were different from known CCN2-derived circRNAs. Moreover, the expression of several Ccn2-derived circRNAs in murine chondroblastic ATDC5 cells was confirmed and observed to change alongside chondrocytic differentiation. Next, one of these circRNAs was knocked down in HCS-2/8 cells to investigate the function of the human CCN2-derived circRNA. As a result, CCN2-derived circRNA knockdown significantly reduced the expression of aggrecan mRNA and proteoglycan synthesis. Our data suggest that CCN2-derived circRNAs are expressed in chondrocytes and play a role in chondrogenic differentiation.

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DOI： 10.1007/s12079-023-00782-7

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Other Link： https://link.springer.com/article/10.1007/s12079-023-00782-7/fulltext.html

Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.ajoms.2023.08.015

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Language：Japanese   Publisher：中・四国矯正歯科学会  

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Publishing type：Research paper (scientific journal)   Publisher：Wiley  

DOI： 10.1002/osi2.1186

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Language：English  

Appropriate operations in severe anterior open bite (AOB) cases are extremely complicated to perform because of the multiple surgical procedures involved, the difficulty of predicting posttreatment aesthetics, and the high relapse rate. We herein report a 16-year-old girl with skeletal Class II, severe AOB malocclusion, and crowding with short roots, and aesthetic and functional problems. Four-piece segmental Le Fort I osteotomy with horseshoe osteotomy was performed for maxillary intrusion, and bilateral sagittal split ramus osteotomy (SSRO) and genioplasty were performed for mandibular advancement. The malocclusion and skeletal deformity were significantly improved by the surgical orthodontic treatment. Functional and aesthetic occlusion with an improved facial profile was established, and no further root shortening was observed. Acceptable occlusion and dentition were maintained after a two-year retention period. This strategy of surgical orthodontic treatment with a complicated operative procedure might be effective for correcting certain severe AOB malocclusion cases.

DOI： 10.18926/AMO/64369

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Language：English   Publishing type：Research paper (scientific journal)  

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Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.ajoms.2023.01.005

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Language：Japanese   Publisher：(公社)日本口腔外科学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J01073&link_issn=&doc_id=20230201450002&doc_link_id=10.5794%2Fjjoms.69.9&url=https%3A%2F%2Fdoi.org%2F10.5794%2Fjjoms.69.9&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Language：Japanese   Publisher：(一社)日本口蓋裂学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J01071&link_issn=&doc_id=20221208300004&doc_link_id=10.11224%2Fcleftpalate.47.210&url=https%3A%2F%2Fdoi.org%2F10.11224%2Fcleftpalate.47.210&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Publishing type：Research paper (scientific journal)   Publisher：Wiley  

DOI： 10.1111/1348-0421.12944

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Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/1348-0421.12944

Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND: We investigated and compared the osteogenic potential and bone regeneration capacities of dedifferentiated fat cells (DFAT cells) and adipose-derived stem cells (ASCs). METHOD: We isolated DFAT cells and ASCs from GFP mice. DFAT cells were established by a new culture method using a mesh culture instead of a ceiling culture. The isolated DFAT cells and ASCs were incubated in osteogenic medium, then alizarin red staining, alkaline phosphatase (ALP) assays, and RT-PCR (for RUNX2, osteopontin, DLX5, osterix, and osteocalcin) were performed to evaluate the osteoblastic differentiation ability of both cell types in vitro. In vivo, the DFAT cells and ASCs were incubated in osteogenic medium for four weeks and seeded on collagen composite scaffolds, then implanted subcutaneously into the backs of mice. We then performed hematoxylin and eosin staining and immunostaining for GFP and osteocalcin. RESULTS: The alizarin red-stained areas in DFAT cells showed weak calcification ability at two weeks, but high calcification ability at three weeks, similar to ASCs. The ALP levels of ASCs increased earlier than in DFAT cells and showed a significant difference (p < 0.05) at 6 and 9 days. The ALP levels of DFATs were higher than those of ASCs after 12 days. The expression levels of osteoblast marker genes (osterix and osteocalcin) of DFAT cells and ASCs were higher after osteogenic differentiation culture. CONCLUSION: DFAT cells are easily isolated from a small amount of adipose tissue and are readily expanded with high purity; thus, DFAT cells are applicable to many tissue-engineering strategies and cell-based therapies.

DOI： 10.3390/ijms222212392

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Language：English  

We herein report the case of a 19-year-old female with a transverse discrepancy, skeletal Class II malocclusion, severe crowding with concerns of classic-type Ehlers-Danlos syndrome (EDS), aesthetics problems and functional problems. The main characteristics of classic EDS are loose-jointedness and fragile, easily bruised skin that heals with peculiar "cigarette-paper" scars. The anteroposterior and transverse skeletal discrepancies can generally be resolved by maxilla repositioning and mandibular advancement surgery following pre-surgical orthodontic treatment. However, this patient was treated with orthodontic camouflage but not orthognathic surgery because of the risks of skin bruising, poor healing and a temporomandibular disorder. A satisfactory dental appearance and occlusion were achieved after camouflage treatment with orthodontic anchor screws and the use of Class II elastics, including the preservation of the stomatognathic functions. Acceptable occlusion and dentition were maintained after a two-year retention period. This treatment strategy of orthodontic camouflage using temporary anchorage, such as anchor screws and Class II elastics, may be a viable treatment option for skeletal malocclusion patients with EDS.

DOI： 10.18926/AMO/61902

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Language：English   Publishing type：Research paper (scientific journal)  

OBJECTIVES: Anti-osteoclastic treatments for breast cancer occasionally cause medication-related osteonecrosis of the jaw. Moreover, elevated glycolytic activity, which is known as the Warburg effect, is usually observed in these breast cancer cells. Previously, we found that cellular communication network factor 2 (CCN2) production and glycolysis enhanced each other in chondrocytes. Here, we evaluated the interplay between CCN2 and glycolysis in breast cancer cells, as we suspected a possible involvement of CCN2 in the Warburg effect in highly invasive breast cancer cells. METHODS: Two human breast cancer cell lines with a distinct phenotype were used. Glycolysis was inhibited by using 2 distinct compounds, and gene silencing was performed using siRNA. Glycolysis and the expression of relevant genes were monitored via colorimetric assays and quantitative RT-PCR, respectively. RESULTS: Although CCN2 expression was almost completely silenced when treating invasive breast cancer cells with a siRNA cocktail against CCN2, glycolytic activity was not affected. Notably, the expression of glycolytic enzyme genes, which was repressed by CCN2 deficiency in chondrocytes, tended to increase upon CCN2 silencing in breast cancer cells. Inhibition of glycolysis, which resulted in the repression of CCN2 expression in chondrocytic cells, did not alter or strongly enhanced CCN2 expression in the invasive and non-invasive breast cancer cells, respectively. CONCLUSIONS: High CCN2 expression levels play a critical role in the invasion and metastasis of breast cancer. Thus, a collapse in the intrinsic repressive machinery of CCN2 due to glycolysis may induce the acquisition of an invasive phenotype in breast cancer cells.

DOI： 10.1016/j.job.2020.07.001

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Language：Japanese   Publisher：(公社)日本口腔外科学会  

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J01073&link_issn=&doc_id=20200828330010&doc_link_id=130007928053&url=https%3A%2F%2Fci.nii.ac.jp%2Fnaid%2F130007928053&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_1.gif

Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND/AIM: Hepatitis B core (HBc) antibody positivity indicates a history of hepatitis B virus (HBV) infection and latent infection. PATIENTS AND METHODS: We conducted a retrospective case-control study of 512 and 495 head and neck cancer (HNC) and non-HNC patients treated at the Okayama University Hospital, Head and Neck Cancer Center from 2008-2017. Demographic data and risk factors that might affect HNC diagnosis were analyzed to assess their effects. RESULTS: Cancer diagnosis was found to correlate with HBc antibody positivity [odds ratio (OR)=1.50, 95% confidence interval (CI)=1.09-2.08], smoking (OR=3.03, 95%CI=2.16-4.25), and a previous history of cancer (OR=4.12, 95%CI=2.79-6.09). The HBs antigen positivity rate in both groups was very close to that observed in the general Japanese population. The HBc antibody positivity rate was very high only in the HNC group. CONCLUSION: HBc antibody positivity and HNC are epidemiologically correlated.

DOI： 10.21873/anticanres.14209

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Language：English  

OBJECTIVE: This report describes the case of a male patient with a complete unilateral cleft lip and palate who presented with midface deficiency and an anteroposteriorly constricted maxilla. DESIGN: Case report Interventions: Correction involved anterior distraction of the segmented maxilla. RESULTS: The present case demonstrates that elongation of the maxilla with anterior distraction is an effective way to develop a proper dental arch, correct anterior and posterior crowding, and improve a midface deficiency.

DOI： 10.1177/1055665618821831

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Authorship：Last author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

Abstract

Intermittent parathyroid hormone (PTH) administration is known to promote bone healing after surgical procedures. However, the mechanism and influence of PTH on the mineral and collagen quality of the jaw are not well understood. Most studies have focused on analyzing the bone density and microstructure of the mandible, and have insufficiently investigated its mineral and collagen quality. Oxidative stress activates osteoclasts, produces advanced glycation end products, and worsens mineral and collagen quality. We hypothesized that PTH induces oxidation and affects the mineral and collagen quality of newly formed mandibular bone. To test this, we examined the mineral and collagen quality of newly formed mandibular bone in rats administered PTH, and analyzed serum after intermittent PTH administration to examine the degree of oxidation. PTH administration reduced mineralization and worsened mineral and collagen quality in newly formed bone. In addition, total anti-oxidant capacity in serum was significantly decreased and the oxidative-INDEX was increased among PTH-treated compared to vehicle-treated rats, indicating serum oxidation. In conclusion, intermittent administration of PTH reduced mineral and collagen quality in newly formed mandibular bone. This effect may have been induced by oxidation.

DOI： 10.1038/s41598-019-44389-8

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Other Link： https://www.nature.com/articles/s41598-019-44389-8

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japanese Society of Jaw Deformities  

DOI： 10.5927/jjjd.29.295

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Language：Japanese   Publisher：岡山歯学会  

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Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

DOI： 10.1007/s00221-018-5377-1

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Other Link： http://link.springer.com/content/pdf/10.1007/s00221-018-5377-1.pdf

Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.pdj.2018.09.002

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Language：English  

OBJECTIVES: To evaluate the effects of maxillary anterior segmental distraction osteogenesis (MASDO) in patients with cleft lip and palate (CLP) and to identify risk factors for increased relapse. DESIGN: A retrospective study. PATIENTS: Thirty-one Japanese patients with CLP who underwent MASDO were eligible for study inclusion. MAIN OUTCOME MEASURES: We evaluated lateral cephalograms obtained before (T1), at 3 months (T2), and at 1 year (T3) after MASDO, and measured changes from T1 to T2 (δT1T2), from T2 to T3 (δT2T3), and from T1 to T3 (δT1T3). We also evaluated the risk factors associated with an increased relapse. RESULTS: Overall (δT1T3), MASDO improved retrusion of the maxilla. We measured a significant advancement (6.1 mm) of the anterior maxillary segment in δT1T2 (A-McNamara classification) and increases in the overjet and the SNA, ANB, and nasolabial angles. However, skeletal relapse was evident in δT2T3, and the median percentage of relapse was 10%. To explore the risk factors, we subdivided patients with a δT1T2 of >5 mm into 2 groups based on the percentage of relapse (>15% vs ≤15%). There were significant differences between these groups in the vertical positions of the anterior nasal spine and point A, and the angle formed by the SN and palatal planes (SNPP), suggestive of intraoperative counterclockwise rotation of the maxilla. CONCLUSIONS: MASDO is effective for correcting midfacial deficiencies, but counterclockwise rotation of the maxilla during surgery may cause relapse.

DOI： 10.1177/1055665618758692

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Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.bjoms.2018.08.003

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Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.ijom.2018.02.002

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Authorship：Last author   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.ajoms.2017.12.005

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Language：Japanese   Publisher：日本骨形態計測学会  

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.pdj.2017.10.001

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Publishing type：Research paper (scientific journal)   Publisher：Informa UK Limited  

DOI： 10.1080/00207454.2017.1381697

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Language：English   Publishing type：Research paper (scientific journal)  

The CCN family consists of 6 genes in the mammalian genome and produces multifunctional proteins involved in a variety of biological processes. Recent reports indicate the profound roles of CCN2 in energy metabolism in chondrocytes, and Ccn2 deficiency is known to alter the expression of 2 other family members including Ccn3. However, almost nothing is known concerning the regulation of the CCN family genes by energy metabolism. In order to gain insight into this critical issue, we initially and comprehensively evaluated the effect of inhibition of glycolysis on the expression of all of the CCN family genes in chondrocytic cells. Upon the inhibition of a glycolytic enzyme, repression of CCN2 expression was observed, whereas CCN3 expression was conversely induced. Similar repression of CCN2 was conferred by the inhibition of aerobic ATP production, which, however, did not induce CCN3 expression. In contrast, glucose starvation significantly enhanced the expression of CCN3 in those cells. The results of a reporter gene assay using a molecular construct containing a CCN3 proximal promoter revealed a dose-dependent induction of the CCN3 promoter activity by the glycolytic inhibitor in chondrocytic cells. These results unveiled a critical role of glycolytic activity in the regulation of CCN2 and CCN3, which activity mediated the mutual regulation of these 2 major CCN family members in chondrocytes.

DOI： 10.1007/s12079-017-0420-8

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.jds.2017.03.007

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DOI： 10.18926/AMO/55589

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Language：Japanese   Publisher：(公社)日本口腔外科学会  

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2017&ichushi_jid=J01073&link_issn=&doc_id=20171130350014&doc_link_id=10.5794%2Fjjoms.63.593&url=https%3A%2F%2Fdoi.org%2F10.5794%2Fjjoms.63.593&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Language：English   Publishing type：Research paper (scientific journal)  

Platinum-based chemotherapy plus cetuximab represents the first-line treatment for recurrent or metastatic squamous cell carcinoma of the head and neck. The most common adverse events associated with cetuximab are infusion reactions and skin reactions, and a risk of venous thromboembolic events has also recently been reported in association with cetuximab. It is well known that thrombosis is a common complication of malignancy, and represents the second most frequent cause of mortality in cancer patients. The present study reports the case of a 79-year-old man who presented with lung and liver metastases from tongue squamous cell carcinoma, for which platinum-based chemotherapy plus cetuximab was administered. After 1 cycle, the patient showed rapid growth of a left ventricular (LV) thrombus, despite ongoing antiplatelet therapy for an old myocardial infarction. Anticoagulant therapy was administered to treat the LV thrombus, which resolved within 1 week. To the best of our knowledge, this represents the first reported case of rapidly occurring LV thrombus associated with platinum-based chemotherapy plus cetuximab. Platinum-based chemotherapy plus cetuximab may be associated with a higher risk of embolic thrombus.

DOI： 10.3892/mco.2017.1393

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Authorship：Last author   Publishing type：Research paper (scientific journal)   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

DOI： 10.5794/jjoms.63.506

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1597/14-326

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Publishing type：Research paper (scientific journal)   Publisher：Wiley  

DOI： 10.1002/ccr3.751

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Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

DOI： 10.1007/s11064-016-2003-0

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Other Link： http://link.springer.com/article/10.1007/s11064-016-2003-0/fulltext.html

Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.ajoms.2016.03.009

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Language：Japanese   Publisher：中国四国産科婦人科学会  

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DOI： 10.3892/ijo.2016.3548

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1597/14-322

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Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.reth.2016.02.006

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Publishing type：Research paper (scientific journal)   Publisher：Oxford University Press (OUP)  

DOI： 10.1093/jscr/rjw011

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DOI： 10.1016/j.ajoms.2015.07.001

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Okayama University  

Scopus

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Authorship：Last author   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.ajoms.2015.02.002

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Publishing type：Research paper (scientific journal)   Publisher：Ovid Technologies (Wolters Kluwer Health)  

DOI： 10.1097/scs.0000000000002127

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.ajoms.2014.11.007

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1597/13-278

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.18926/AMO/53525

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Other Link： http://orcid.org/0000-0002-4419-9643

Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

DOI： 10.1007/s11064-015-1555-8

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Other Link： http://link.springer.com/article/10.1007/s11064-015-1555-8/fulltext.html

Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

DOI： 10.1007/s10571-014-0137-7

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Other Link： http://link.springer.com/article/10.1007/s10571-014-0137-7/fulltext.html

Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

DOI： 10.1007/s00221-015-4203-2

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Other Link： http://link.springer.com/article/10.1007/s00221-015-4203-2/fulltext.html

Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

DOI： 10.1007/s11064-014-1484-y

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Other Link： http://link.springer.com/article/10.1007/s11064-014-1484-y/fulltext.html

Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

Bilateral chylothorax is a rare complication after radical neck dissection. We report a case of bilateral chylothorax that developed after left radical neck dissection. A 40-year-old man was given a diagnosis of secondary left cervical lymph-node metastasis from left-sided tongue cancer (T1N0M0), and supraomohyoid neck dissection was performed. Since multiple lymph-node metastases had been found, modified radical neck dissection was performed. We ligated the thoracic duct because it ruptured intraoperatively. On the first postoperative day, a chyle leak was diagnosed, and the thoracic duct was ligated again. The chyle leak resolved, but on the fourth postoperative day, the patient complained of dyspnea and chest discomfort. Computed tomographic scans and chest X-ray films showed bilateral pleural effusions. Diagnostic thoracentesis was performed. Milky fluid was aspirated, and chylothorax was diagnosed. We used a conservative management approach, which involved total parenteral nutrition with total enteric rest. Repeated chest X-ray films showed no evidence of pleural effusion, and the patient was started to receive a low-fat diet on the 11th postoperative day. The patient had recovered completely.

DOI： 10.5794/jjoms.61.288

CiNii Article

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Other Link： https://jlc.jst.go.jp/DN/JLC/20011890438?from=CiNii

Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

Mesothelioma is a rare neoplasm that arises from the pleura or peritoneum. Although malignant mesothelioma is known to spread hematogenously, causing metastasis to various organs, there have been few reports on oral metastasis. The patient was a 75-year-old man who had an elastic soft mass, measuring 38 × 20 mm, in the right upper jaw gingiva. On biopsy the lesion was histopathologically diagnosed as a malignant pleural mesothelioma with metastasis to the upper jaw. The lesion shrank in response to radiotherapy. We have described a case of malignant pleural mesothelioma arising in the upper jaw gingiva. We discuss the related literature and summarize our findings.

DOI： 10.5794/jjoms.61.168

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Other Link： https://jlc.jst.go.jp/DN/JLC/20009068467?from=CiNii

Language：Japanese   Publisher：岡山歯学会  

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Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.archoralbio.2014.08.008

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DOI： 10.1002/jbm.a.34966

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Publishing type：Research paper (scientific journal)   Publisher：Wiley  

DOI： 10.1002/jcb.24728

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Publishing type：Research paper (scientific journal)   Publisher：American Society for Microbiology  

ABSTRACT

Periodontitis is an inflammatory disease of polymicrobial origin affecting the tissues supporting the tooth. The oral anaerobic bacterium Porphyromonas gingivalis , which is implicated as an important pathogen for chronic periodontitis, triggers a series of host inflammatory responses that promote the destruction of periodontal tissues. Among the virulence factors of P. gingivalis , hemoglobin receptor protein (HbR) is a major protein found in culture supernatants. In this study, we investigated the roles of HbR in the production of inflammatory mediators. We found that HbR induced interleukin-8 (IL-8) production in the human gingival epithelial cell line Ca9-22. p38 mitogen-activated protein kinase (MAPK) and extracellular signal-related kinase 1/2 (Erk1/2) were activated in HbR-stimulated Ca9-22 cells. Inhibitors of p38 MAPK (SB203580) and Erk1/2 (PD98059) blocked HbR-induced IL-8 production. Additionally, HbR stimulated the translocation of NF-κB-p65 to the nucleus, consistent with enhancement of IL-8 expression by activation of the NF-κB pathway. In addition, small interfering RNA (siRNA) targeting activating transcription factor 2 (ATF-2) or cyclic AMP-response element-binding protein (CREB) inhibited HbR-induced IL-8 production. Moreover, pretreatment with SB203580 and PD98059 reduced HbR-induced phosphorylation of CREB and ATF-2, respectively. Combined pretreatment with an inhibitor of NF-κB (BAY11-7082) and SB203580 was more efficient in inhibiting the ability of HbR to induce IL-8 production than pretreatment with either BAY11-7082 or SB203580 alone. Thus, in Ca9-22 cells, the direct activation of p38 MAPK and Erk1/2 by HbR caused the activation of the transcription factors ATF-2, CREB, and NF-κB, thus resulting in the induction of IL-8 production.

DOI： 10.1128/iai.01140-12

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.jcms.2012.01.021

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Language：English   Publisher：(公社)日本生化学会  

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Language：Japanese   Publisher：(一社)歯科基礎医学会  

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Bone healing is a complex and multistep process in which the origin of the cells participating in bone repair is still unknown. The involvement of bone marrow-derived cells in tissue repair has been the subject of recent studies. In the present study, bone marrow-derived cells in bone healing were traced using the GFP bone marrow transplantation model. Bone marrow cells from C57BL/6-Tg (CAG-EGFP) were transplanted into C57BL/6 J wild mice. After transplantation, bone injury was created using a 1.0-mm drill. Bone healing was histologically assessed at 3, 7, 14, and 28 postoperative days. Immunohistochemistry for GFP; double-fluorescent immunohistochemistry for GFP-F4/80, GFP-CD34, and GFP-osteocalcin; and double-staining for GFP and tartrate-resistant acid phosphatase were performed. Bone marrow transplantation successfully replaced the hematopoietic cells into GFP-positive donor cells. Immunohistochemical analyses revealed that osteoblasts or osteocytes in the repair stage were GFP-negative, whereas osteoclasts in the repair and remodeling stages and hematopoietic cells were GFP-positive. The results indicated that bone marrow-derived cells might not differentiate into osteoblasts. The role of bone marrow-derived cells might be limited to adjustment of the microenvironment by differentiating into inflammatory cells, osteoclasts, or endothelial cells in immature blood vessels.

DOI： 10.1007/s00223-012-9685-3

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DOI： 10.1016/j.ajodo.2011.11.024

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Language：English   Publisher：JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY  

Defensins are generally implicated in the quick resistance of epithelial surfaces to microbials; however, recent reports have indicated that defensins also have unknown purposes in relation to noninfectious diseases. In this study, the localization patterns of anti-microbial peptides, β defensins (BDs), in the tracheal epithelium of male C3H mice under exposure to toluene were analyzed by immunohistochemistry. Mice were exposed one to ten times to toluene for 30 min by nose-only inhalation. Expression of BDs was revealed by immunohistochemistry in serial sections of trachea after the final exposure. Expression of BD-1 was usually observed at almost the same levels in all exposure groups, and expression of BD-2 was observed in the control group; however, the signals for BD-2 decreased gradually with frequency of exposure. In the group exposed ten times, expression of BD-2 decreased to far lower than that of the control group. No expression of BD-3 was detected in any groups. Interestingly, expression of BD-4 increased to the maximum in the group exposed four times and decreased to a level lower than that of the control in the group exposed ten times. The results of the present study indicated that toluene gas might change the expression pattern of BDs in the tracheal epithelial cells. The oscillation of expression of BD-4 was quite characteristic and might contribute to morphological damage in on the epithelial cells.

DOI： 10.1293/tox.26.35

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Other Link： https://jlc.jst.go.jp/DN/JALC/10017550764?from=CiNii

Language：English   Publisher：THE JAPANESE SOCIETY FOR JAW DEFORMITIES  

DOI： 10.5927/jjjd.22.S7

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Other Link： http://search.jamas.or.jp/link/ui/2013185847

Language：Japanese   Publisher：日本再生歯科医学会  

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Language：Japanese   Publisher：岡山歯学会  

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DOI： 10.1016/j.oooo.2012.05.019

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Language：Japanese   Publisher：(一社)歯科基礎医学会  

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DOI： 10.1016/j.jcms.2011.04.019

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DOI： 10.1007/s10735-011-9385-8

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DOI： 10.2485/jhtb.21.87

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Publishing type：Research paper (scientific journal)   Publisher：Hindawi Limited  

<italic>Objectives</italic>. To clarify the difference between Lyapunov exponents (LEs) for cleft palate (CP) patients with hypernasality versus without hypernasality and to investigate the relationship between their LEs and nasalance scores (NSs).<italic>Material and Methods</italic>. Six CP patients with severe hypernasality (mean age 9.2 years) and six CP patients without hypernasality (mean age 8.0 years) were enrolled. Five Japanese vowels were recorded at 44.1 KHz, and the NSs were measured simultaneously. The mean first LE (mLE₁) from all one-second intervals was computed.<italic>Results</italic>. The mLE₁for /o/ in patients with hypernasality was significantly higher than that in patients without hypernasality. The correlation coefficients between the mLE₁and NS for all vowels were not statistically different.<italic>Conclusion</italic>. The voice signal of /o/ for the patients with hypernasality was more instable than in those without hypernasality. The chaotic phenomenon was independent of nasal resonance in CP voice.

DOI： 10.1155/2012/739523

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Other Link： http://downloads.hindawi.com/journals/ijoto/2012/739523.xml

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DOI： 10.1016/j.bjoms.2010.09.004

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DOI： 10.1016/j.febslet.2011.08.024

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DOI： 10.1097/SCS.0b013e31822e5ebf

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Language：Japanese   Publisher：(公社)日本口腔外科学会  

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DOI： 10.1007/s12079-011-0135-1

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DOI： 10.1097/SCS.0b013e318208bacf

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Journal of Clinical Pediatric Dentistry  

DOI： 10.17796/jcpd.36.2.r7853hp574045414

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer-Verlag Tokyo  

DOI： 10.1007/s00540-011-1204-6

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DOI： 10.18926/AMO/40134

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DOI： 10.1016/j.ajoms.2009.05.003

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Language：Japanese   Publisher：(一社)日本顎関節学会  

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Language：Japanese   Publisher：(公社)日本口腔外科学会  

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Language：Japanese   Publisher：(NPO)日本口腔科学会  

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2010&ichushi_jid=J01072&link_issn=&doc_id=20100520230002&doc_link_id=%2Fcp8stoma%2F2010%2F005902%2F003%2F0068-0078%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcp8stoma%2F2010%2F005902%2F003%2F0068-0078%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese   Publishing type：Research paper (scientific journal)  

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Language：English   Publisher：11  

DOI： 10.1177/0022034509345998

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AIM: The purpose of this study was to examine morphological changes of the mandibular region using frontal cephalograms following bilateral sagittal split osteotomy (BSSO) for mandibular setback. Furthermore, we compared the stability between screw and plate fixation. METHODS: Pre and postoperative frontal cephalograms were taken of 26 patients. Parameters, Angle "A" which is formed by constructed lines along the mandibular ramus, and mandibular width at the angle were calculated. The subjects were analyzed according to the types of bony fixation, whether by screws or plates. RESULTS: Angle "A" and mandibular angular width of total numbers did not widely change at early period following operation. Late postoperatively, mandibular width of total numbers decreased in conjunction with increasing Angle "A". When comparing the parameters between screw and plate groups, the plate group showed a decrease of Angle "A" as an early change. Late postoperatively, the plate group showed an increase of Angle "A" and a decrease of mandibular width, while the screw group had smaller changes. CONCLUSION: We demonstrate postoperative inclination of mandibular lower ramus towards the facial midline. We suggest that the types of rigid fixation have an influence on frontal skeletal morphology, namely that screw fixation has higher stability.

DOI： 10.1016/j.jcms.2009.04.012

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Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

Epulis osteoplastica is a rare disease. We report a case of giant epulis osteoplastica containing a largesequestrum. A 63-year-old man was referred to our clinic because of a painless swelling on the left mandibularalveolus. Intraoral examination revealed an elastic hard tumor with a normal surface in the left lower molar region.Radiographic examination showed a large radiopaque mass separate from mandibular bone. Gingival tumor excisionwas performed with the patient under general anesthesia. The excised specimen measured 50 X 38 X 28mm and contained the bony mass. Histopathologically, the lesion was diagnosed as epulis osteoplastica with asequestrum. The patient was followed up for 4 years after the operation, without any recurrence.

DOI： 10.5794/jjoms.55.453

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Other Link： https://jlc.jst.go.jp/DN/JALC/00338247726?from=CiNii

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DOI： 10.1097/01.ta.0000245948.68844.00

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DOI： 10.1016/j.tripleo.2008.07.006

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DOI： 10.1016/j.ijom.2008.04.016

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Language：Japanese   Publisher：(NPO)日本口腔科学会  

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2008&ichushi_jid=J01072&link_issn=&doc_id=20080814280010&doc_link_id=%2Fcp8stoma%2F2008%2F005703%2F011%2F0311-0314%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcp8stoma%2F2008%2F005703%2F011%2F0311-0314%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese   Publisher：(公社)日本口腔外科学会  

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2008&ichushi_jid=J01073&link_issn=&doc_id=20080430380003&doc_link_id=10.5794%2Fjjoms.54.234&url=https%3A%2F%2Fdoi.org%2F10.5794%2Fjjoms.54.234&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Publishing type：Research paper (scientific journal)   Publisher：SAGE Publications  

The finding that the vomer plays a crucial role in maxillary growth suggests that the bilateral cleft configuration of unilateral cleft lip and palate (UCLP), in which the vomer is detached from the non-cleft-side secondary hard palate, negatively influences palatal development, and this hypothesis was tested. Sixty persons with complete UCLP, including those with the vomer detached from (n = 30, b-UCLP) and attached to (n = 30, u-UCLP) the secondary hard palate, were analyzed morphologically, with the use of cast models taken at 10 days, 3 mos, and 12 mos of age. The anterio-posterior palatal length at 12 mos of age in those with b-UCLP was significantly shorter than that in those with u-UCLP, by 8.7% (p &lt; 0.05). In addition, palatal width development in the first year in those with b-UCLP was also significantly retarded. These results suggest that the uncommon bilateral cleft subtype in UCLP should be included in the cleft classification.

DOI： 10.1177/154405910808700212

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Other Link： http://journals.sagepub.com/doi/full-xml/10.1177/154405910808700212

Publishing type：Research paper (scientific journal)  

DOI： 10.1111/j.1601-0825.2006.01340.x

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Language：Japanese   Publisher：(公社)日本口腔外科学会  

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2007&ichushi_jid=J01073&link_issn=&doc_id=20071025390004&doc_link_id=10.5794%2Fjjoms.53.603&url=https%3A%2F%2Fdoi.org%2F10.5794%2Fjjoms.53.603&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Language：Japanese   Publisher：大阪大学歯学会  

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Language：Japanese   Publisher：大阪大学歯学会  

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Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

Bisphosphonates (BPs) are widely used for the management of hypercalcemia related to malignancy and bone metastases from breast cancer in Japan. We report a case of osteonecrosis of the jaw (ONJ) associated with a history of BPs therapy forthe management of bone metastases from breast cancer. A 69-year-old woman was referred to our department becaused of unhealed extraction sockets of the lower left premolar and first molar, which were removed at a dental clinic. CT scans of the mandible showed regions of mottled bone and sequestra, and a clinical diagnosis of ONJ was made. After conservative treatment with antibiotics and local minor curettage, the inflammatory symptoms almost completely disappeared. Dentists should be aware of this potentially serious complication in patients receiving long-term treatment with BPs.

DOI： 10.5794/jjoms.53.28

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DOI： 10.1111/j.1600-0714.2006.00409.x

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BACKGROUND: The frequent insertion of self-tapping screws for securing the proximal positioning plate in bimaxillary osteotomy often cause loosening of screws and plate, which produces incorrect repositioning. In this article, a newly developed base-attachment for a T-shaped proximal positioning plate for bimaxillary osteotomy is presented. MATERIAL: The base-attachment set consists of a titanium base-attachment and two titanium tapped screws. The attachment has a shallow depression having the same shape as the basal part of the positioning plate. METHOD: The base-attachment is secured by self-tapping screws until the end of the procedure, and the T-shaped proximal positioning plate is placed and secured by two titanium-tapped screws. RESULT: By using this base-attachment, the T-shaped plate can be easily placed repeatedly without difficulty. CONCLUSION: This base-attachment set may be useful for the frequently repositioned proximal plate in bimaxillary osteotomy.

DOI： 10.1016/j.jcms.2006.01.002

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Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

Chickenpox is a common infection due to varicella-zoster virus (VZV), which generally occurs in childhood. However, the incidence of chickenpox in adults is increasing because of changes in the social environment. In this paper, we report a case of adult chickenpox with the first symptom in the oral cavity. A 32-year-old Japanese woman presented with palatal ulcerative lesions and many bullae on her skin. The first symptom was continuous spontaneous pain at the left upper molar, present for 15 days before her first visit. Intravenous and oral acyclovir was given for a clinical diagnosis of VZV infection. Although the serum antibody examination showed no evidence of VZV infection, the symptoms led to a diagnose of adult chickenpox.

DOI： 10.5794/jjoms.51.505

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DOI： 10.1016/j.oraloncology.2005.03.006

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DOI： 10.1016/j.joms.2005.01.011

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DOI： 10.1111/j.1600-0714.2005.00304.x

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Language：Japanese   Publisher：(NPO)日本口腔科学会  

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Language：Japanese   Publisher：大阪大学歯学会  

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Open vertical osteotomy in the mandibular ramus is the one surgical option for the correction of mandible deformity. It is easy to assume that this procedure is useful for open reduction of condylar fractures. In this paper we describe a new systematic procedure for open reduction of high condylar fractures. The procedure involves vertical subcondylotomy and a new retractor for subcondylotomy to protect the mandibular neurovascular bundle.<BR>The major points of this operation are the use of vertical condylotomy, removal of the posterior border of the ramus and plating the condylar head with it, and accurate replacement of the posterior border of the ramus with mini plates prepared before osteotomy.

DOI： 10.5794/jjoms.44.412

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Other Link： http://search.jamas.or.jp/link/ui/1998198548

Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

In this study, we clinically observed 146 patients with sports-related oral and maxillofacial fractures treated at the First Department of Oral and Maxillofacial Surgery, Osaka University Faculty of Dentistry during the past 15 years. The results were as follows.<BR>Among 146 patients, 134 were male and 12 were female. Although 62.5% of the patients were 15 to 24 years of age, there was an annual trend toward a decrease in patients aged 15 to 19 years. The most common causative sport event was baseball (54 patients), followed by rugby football (26 patients) and soccer (15 patients). There was also a decrease in baseballrelated cases and an increase in soccer-related cases in recent years. Isolated mandibular fractures occurred in 92 patients, and the most common site was the mandibular angle, followed by the condyle and canine. Among 37 isolated midface fractures, the most common site was the zygomatic arch (14 patients).<BR>Baseball-related mandibular fractures had a high incidence of two-line fractures and fractures of the anterior portion of the mandibular body as compared with other events.

DOI： 10.5794/jjoms.44.805

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Other Link： http://search.jamas.or.jp/link/ui/1999069467

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DOI： 10.11277/stomatology1952.46.393

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Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

We report six cases of unilateral transverse facial cleft. Five patients were male and one was female. One case was diagnosed as solitary macrostomia, and other cases had accessory ears. Among latter cases, one also suffered from microtia and was diagnosed as the first and second branchial syndrome. Another case was diagnosed as Goldenhar syndrome because of the presence of epibulbar dermoid. The other cases were diagnosed as the first branchial syndrome.

DOI： 10.5794/jjoms.43.373

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Other Link： http://search.jamas.or.jp/link/ui/1997193080

Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

Eight patients with unilateral condylar fractures of the mandible who were treated at our clinic by Martin-Eckelt lag screw osteosynthesis are described.<BR>The patients were aged 14 to 78 years. There were 4 males and 4 females. Four patients had fractures of the base of the condylar process, and four had fractures of the condylar neck. Two patients had no dislocation, four had dislocation, and two had luxation. Clinical examinations 6 months after primary operation showed that mouth opening was not less than 40mm in any patient. Radiographic examinations revealed a correct position and normal form of the condylar head in six patients, but resorption of the condylar head was found in two patients. These two patients required extirpation of condylar head for reduction. Since the use of a lag screw decreases the supply of nutrients from the bone marrow of mandibular ramus to the condylar head, the condylar head should not be removed from the surrounding soft tissue during operation.

DOI： 10.5794/jjoms.43.927

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Other Link： http://search.jamas.or.jp/link/ui/1998090003

Language：Japanese   Publisher：Japanese Stomatological Society  

Sialolith usually occurs in the submandibular gland and its occurrence in the parotid gland is relatively rare. Especially the occurrence of sialoliths in the bilateral parotid gland is very rare and only three cases of such a case have been reported. In this paper, a case of sialolithiasis occurring in the bilateral parotid gland was reported.<BR>The patient, a 65-year-old Japanese male, visited our clinic complaining of swelling of the right buccal mucosa including the orifice of the parotid duct. Roentogen examination revealed the presense of sialoliths in the right parotid duct and the deep lobe of the left parotid gland. Extirpation of the sialoliths of the right parotid duct was performed under local anesthesia, and 6 sialoliths of 2 mm or less in diameter were observed. Though extirpation of the left sialolith was not performed because of lack of objective and subjective symptoms, long-term follow up is considered nessesary.

DOI： 10.11277/stomatology1952.46.187

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Pharyngeal flap surgery is used in the prevention of hypernasality and the devel-opment of articulation disorders that are associated with velopharyngeal incompetence after primary palatal closure. However, surgery may result in failure when the level of the pharyngeal flap base is not determined properly with relation to that of velopharyngeal move-ment or when the flap shrinks because of scar contraction through prolonged exposure of its raw surface. This report describes one patient who had suffered from recurrence of velopharyngeal incompetence after pharyngeal flap surgery. Lateral cephalographic and nasopharyngeal fiberscopic examinations identified the cause of flap atrophy to be marked scar contraction, and the flap base was remarkably lower than the level of velopharyngeal closure in the patient. Unified velopharyngoplasty was newly performed on the basis of find-ings obtained from lateral cephalographic and nasopharyngeal fiberscopic examinations to correct the recurrence of velopharyngeal incompetence in the patient. One year postoperatively, complete closure of the velopharynx in coordination of the flap during speech was confirmed by nasopharyngeal fiberscopy.

DOI： 10.5794/jjoms.42.320

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Other Link： http://search.jamas.or.jp/link/ui/1996193738

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DOI： 10.11277/stomatology1952.45.67

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Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

Hemifacial microsomia is defined as a condition affecting primarily aural, oral, and mandibular development and its clinical features may vary. In this paper we report a case of hemifacial microsomia with cleft palate. A Japanese girl 8 months of age was referred to our clinic for the treatment of cleft palate. Clinically, she had hypoplasia and inferior displacement of the left auricle, stenosis of the external auditory canal, a hypoplastic mandible, and facial palsy at the left side of the lower lip. There was no significant asymmetry of the maxillary dental arch or soft palate, and the left side of the soft palate showed mild hypokinesia. Palatoplasty with a push-back method was performed under general anesthesis at the age of 1 year 5 months. A few reports have shown a trend toward velopharyngeal insufficiency in hemifacial microsomia due to hypoplastic palatal muscles and poor neural control of these muscles. In the future, comprehensive speech therapy will be required in this patient.

DOI： 10.5794/jjoms.42.457

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Other Link： http://search.jamas.or.jp/link/ui/1996234675

Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

We reported two cases of calcifying epithelioma arising in subcutaneous tissue around the auricle. One case was in a 11-year-old Japanese girl who visited our clinic complaining of a mass at the left preauricular region, which had been present since the age of 3. Radiographic examination revealed the presence of calcification measuring 10×8 mm in diameter. Enucleation was performed, and a histopathological diagnosis of a calcifying epithelioma was made. Histopathologically, the tumor was composed mainly of shadow cells, and bone formation was also observed. The other case was in a 52-year old Japanese man, who visited our clinic complaining of a mass at the left side of the neck. The tumor was located at the subauricular region, and the surface of the tumor had undergone partial necrosis. The tumor was enucleated with the surrounding granulation tissue. The histopathological diagnosis was a calcifying epithelioma. Histopathological examination revealed the tumor to be composed of basophilic cells and shadow cells; calcifications were also observed.<BR>The postoperative course of both patients was uneventful, with no evidence of recurrence.

DOI： 10.5794/jjoms.42.693

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DOI： 10.11224/cleftpalate1976.21.3_150

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Language：Japanese   Publisher：医歯薬出版(株)  

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Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

We clinically observed patients with sialolithiasis of the submandibular gland who visited our department during the past 10 years (January 1984 to December 1993). The following results were obtained.<BR>One hundred forty-six cases of sialolithiasis of the submandibular gland were diagnosed. The highest proportion of patients were in their 3rd decade of life, and the ratio of men to women was 1 to 1.4. The most common site of occurrence was within the submandibular duct (84.2%), and larger sialoliths tended to occur in the gland and the transitional portion. The main clinical symptoms of submandibular sialolithiasis were swelling and/or tenderness of the gland, and these symptoms tended to occur on the gland side. Infection of the oral cavity tended to occur on the orifice side.

DOI： 10.5794/jjoms.41.890

CiNii Article

CiNii Books

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Other Link： http://search.jamas.or.jp/link/ui/1996136698

Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

Sialolithiasis mainly occurs in the submandiblar gland and its occurrence in minor salivary glands is very rare. In this paper we report three cases of sialolithiasis occurring in the minor salivary glands of the lip. Two cases occurred in the upper lip and one in the lower lip. Histopathologically, the case in the lower lip consisted of more than six calcified masses in the minor salivary gland tissue.

DOI： 10.5794/jjoms.41.263

CiNii Article

CiNii Books

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Other Link： http://search.jamas.or.jp/link/ui/1995233309

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Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

Benign fibrous histocytoma is a well-established soft tissue neoplasm, and the occurrence of this lesion in the oral cavity is rare. Only 3 cases of this lesion arising centrally in the mandible have been reported in the literature. In this paper, we reported a patient with benign fibrous histiocytoma of the mandible.<BR>A 42-year-old Japanese woman was referred to our department complaining of swelling on the lingual side of the right mandibular body in November 1987. Radiographic examination demonstrated a illdefined radiolucent lesion in the right body of the mandible extending from 7 to the ramus. We performed segmental resection of the mandible in March 1988. A solid yellowish lesion was observed in the mandible body, and partial destruction of the lingual palate was found. Histopathologically, the lesion was composed of spindle-shaped figroblastic cells and histiocytic cells. The histiocytic cells showed negative staining for S-100 protein and positive staining for a-1 antitrypsin. Based on these clinical and histopathological findings, the lesion was diagnosed as benign fibrous histiocytoma. The postoperative course was good and no signs of recurrence have been seen almost 6 years and 4 months after operation.

DOI： 10.5794/jjoms.40.209

CiNii Article

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Other Link： http://search.jamas.or.jp/link/ui/1994186632

Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

This study investigated the correlation between clinical and histopathological findings in 171 cases clinically diagnosed as oral leukoplakia. Histopathological examination revealed squamous cell carcinoma in 14 cases, leukoplakia with epithelial dysplasia in 68 cases, and hyperkeratosis without epithelial dysplasia in 89 cases. According to the grade of epithelial dysplasia, the leukoplakias were classified into mild, moderate, severe epithelial dysplasia and carcinoma in situ, which included 49, 14, 3 and 2 cases, respectively. High grades of epithelial dysplasia were mainly observed on the lateral edge of the tongue or the oral floor. There was a close correlation between the clinical appearance of lesions and a high grade of dysplasia; the majority of the cases with high grades of dysplasia or with early invasive carcinoma clinically showed erosive-type lesions.

DOI： 10.5794/jjoms.40.1290

CiNii Article

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Other Link： http://search.jamas.or.jp/link/ui/1995189697

CiNii Article

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Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

DOI： 10.5794/jjoms.38.1919

CiNii Article

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Other Link： http://search.jamas.or.jp/link/ui/1993238121

Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

Four cases of pituitary hormone deficiency with cleft defects of the lip and palate were reported. In all cases, we noticed the small premaxilla, but there was no cerebral anomaly such as holoprosencephaly.The present report suggests the small premaxilla is a sign of the pituitary hormone deficiency in cleft lip and palate children.This clinical feature would be useful for diagnosis of the pituitary hormone deficiency.

DOI： 10.5794/jjoms.38.818

CiNii Article

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Other Link： http://search.jamas.or.jp/link/ui/1993108987

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Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

Conservative treatment for ameloblastoma frequently produces recurrence. But even after radical treatment for this lesion, recurrence may occur. Recurrence in such cases is most likely due to involvement of adjacent soft tissue structures by tumor tissue.<BR>In such cases of recurrence after conservative treatment, ameloblastoma proliferate immediately in soft tissue and gingiva. We performed segmental resection of mandible bone involving adjacent soft tissue and one-stage microsurgical reconstruction using radial forearm skin flap.

DOI： 10.5794/jjoms.37.398

CiNii Article

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DOI： 10.11224/cleftpalate1976.16.4_190

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Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

As cleidocranial dysplasia is one of the systemic bone disorders characterised by anomalies of clavicle, cranium, maxilla and mandible, complications are rarely found in other than the bone system.<BR>We have examined a boy, 8 years and 3 months old when first seen, of this disease accompanied with pseudohypoparathyroidism I, who is perhaps the second reported case in Japan. He was diagnosed to be pseudohypoparathyroidism I based on the attacks of tetany, calcified bodies in the brain found by CT, low Ca and high P levels in the blood, and on the Ellsworth-Howard examination. He was diagnosed to have cleidocranial dysplasia because of the specific motion of approaching shoulders, late existence of the anterior fontanell, and teeth anomalies as written below.<BR>At the examination of 9 years and 4 months, D+D/D+D and cuspids of E/E/E/E erupted, but no permanent tooth had erupted, all remaining in the jaws ascertained by roentgenography. Several serious carious deciduous teeth were extracted at this time. At the examination of 12 years and 3 months, however, no permanent tooth was seen except for the incisor edges of the lower central incisors.<BR>Cephalometric x-ray analysis at 9 years and 4 months revealed maxillary maldevelopment to anterior and down directions, progenia, and maldevelopment of the mandibular angle. These were also found at the 12 years 3 months examination, but the amount of the maxillary and mandibular developments during these periods were nearly the same as that of normal boys.<BR>The etiology of cleidocrnial dysplasia was discussed based on the present case and on some literatures reporting the complications that accompanied this disease.

DOI： 10.5794/jjoms.35.755

CiNii Article

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Other Link： http://search.jamas.or.jp/link/ui/1990062085

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Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

This study was intended to clarify the mechanical contraction properties of the tensor veli palatini muscle in dogs. Twenty adult dogs were used under an intraperitoneum anesthesia of the pentobarbital sodium. The tension of the tensor veli paltini muscle was recorded by electrical stimulation to the motor nerve.<BR>Results were as follows:<BR>1. The contraction time and half relaxation time of maximal isometric twitch of the muscle were calculated as 13.7±0.7 msec and 10.4±1.2 msec, respectively.<BR>2. A clear summation of muscle contractions was obtained with stimulation at 20 Hz and maximal tetanic tension was at 90 Hz. The tetanus twitch tension ratio wasfound to be 10.7±1.1.<BR>3. The maximum rate of tension rise was observed at 150 Hz and value was 2.5±0.5 times as long as the rate of a twitch contraction.<BR>4. The contraction rate of an isotonic twitch was 3.2±0.7% and the maximum contraction rate was obtained at 80 Hz which was 26.3±1.9%.

DOI： 10.5794/jjoms.34.1845

CiNii Article

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Other Link： http://search.jamas.or.jp/link/ui/1989131379

CiNii Article

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Language：Japanese   Publisher：(NPO)日本口腔科学会  

J-GLOBAL

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Language：Japanese   Publisher：(公社)日本矯正歯科学会  

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Language：Japanese   Publisher：(NPO)日本口腔科学会  

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Language：Japanese   Publisher：日本法歯科医学会  

J-GLOBAL

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Language：Japanese   Publisher：日本歯科衛生学会  

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Language：Japanese   Publisher：(NPO)日本法医学会  

J-GLOBAL

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Language：Japanese   Publisher：(一社)日本口腔内科学会  

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Language：Japanese   Publisher：(一社)日本歯科医学教育学会  

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Language：Japanese   Publisher：(NPO)日本食道学会  

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Language：Japanese   Publisher：(NPO)日本食道学会  

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Language：Japanese   Publisher：(一社)日本口腔内科学会  

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Language：Japanese   Publisher：(一社)日本口蓋裂学会  

J-GLOBAL

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Language：Japanese   Publisher：(一社)日本口腔診断学会  

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Language：Japanese   Publisher：(一社)日本口腔内科学会  

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Language：Japanese   Publisher：(NPO)日本口腔科学会  

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Language：Japanese   Publisher：(公社)日本矯正歯科学会  

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Language：English   Publishing type：Book review, literature introduction, etc.  

DOI： 10.1016/j.jdsr.2012.11.003

Scopus

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Language：Japanese   Publishing type：Research paper, summary (national, other academic conference)   Publisher：(一社)歯科基礎医学会  

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Language：Japanese   Publisher：(NPO)日本口腔科学会  

J-GLOBAL

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Language：Japanese   Publishing type：Research paper, summary (national, other academic conference)   Publisher：(NPO)日本口腔科学会  

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Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

DOI： 10.5794/jjoms.58.501

CiNii Article

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Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

Maxillary anterior segmental distraction osteogenesis (MASDO) is a rather new surgical orthodontic treatment to produce an ideal maxillary dental arch form in patients with cleft lip and palate. Different from total maxillary advancement by DO, this surgical procedure can solves the problems in the small and retruded maxilla without the risk of deterioration of velopharyngeal function, because the distracted segment is only made at the anterior part of the maxillary bone.<br>To advance the anterior segment in only a single vector, a single palatal bone-borne distractor or toothborne distractor is effective, but two hybrid type distractors on each side of alveolar process can produce some rotational movements of anterior segment by controlling advancement amount in each side. Therefore, this procedure solves not only the size of maxillary arch but also the shape of deformed dental arch.<br>As bone height and width at distracted space on alveolar process is enough for fuature alignments of crowding teeth or anterior movement of molars, this treatment is an effective pre-orthodontic surgical treatment for solving discrepancy of maxillary dental arch.

DOI： 10.5794/jjoms.58.562

CiNii Article

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Language：English   Publishing type：Research paper, summary (international conference)  

Web of Science

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Language：Japanese   Publisher：(公社)日本口腔外科学会  

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Language：Japanese   Publisher：岡山歯学会  

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Language：Japanese   Publisher：(NPO)日本口腔科学会  

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Language：Japanese   Publisher：(NPO)日本口腔科学会  

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Language：Japanese   Publishing type：Research paper, summary (national, other academic conference)   Publisher：(公社)日本口腔外科学会  

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Language：Japanese   Publisher：(公社)日本口腔外科学会  

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Language：Japanese   Publisher：(一社)日本口蓋裂学会  

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Language：Japanese   Publisher：(一社)日本口蓋裂学会  

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Language：Japanese   Publisher：(NPO)日本口腔科学会  

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DOI： 10.5843/jsot.19.7

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インプラント体の上顎洞内への迷入症例6例について、カルテ記載事項と画像等の検査結果を後ろ向きに調査した。その結果、迷入判明から当科初診までの期間は当日〜約1ヵ月後であった。初診時年齢は平均57.3歳で、埋入部位は不明の1例を除き上顎第一大臼歯部であった。迷入時期はインプラント埋入時が2例、埋入1週間後に経過不良のためインプラント摘出を試みた際に迷入させた症例が1例、埋入後の経過観察中が1例、上部構造装着後が1例、不詳が1例であった。自覚症状を認めた症例は3例で、いずれも鼻閉等の鼻症状であり、うち1例には嗅覚障害を認めた。インプラント体は全例で結果的に体外に出ており、4例に摘出術を施行し、うち2例が歯槽部からの摘出、1例が犬歯窩(上顎洞開放術)からの摘出、1例が鼻内内視鏡手術であった。残り2例は、消炎および経過観察中に自然排出していた。迷入部位は上顎洞下方4例、上顎洞中央1例、自然孔1例であった。

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Event date： 2016.12.15

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Other Link： http://search.jamas.or.jp/link/ui/2017215458

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A palatal augmentation prosthesis (PAP) is used to facilitate improvement in the speech and swallowing functions of patients with tongue resection or tongue movement disorders. However, a PAP's effect is limited in cases where articulation disorder is severe due to wide glossectomy and/or segmental mandibulectomy. In this paper, we describe speech outcomes of a patient with an articulation disorder following glossectomy and segmental mandibulectomy. We used a palatal plate (PP) based on a PAP, along with an artificial tongue (KAT). Speech improvement was evaluated by a standardized speech intelligibility test consisting of 100 syllables. The speech intelligibility score was significantly higher when the patient wore both the PP and KAT than when he wore neither (p＝0.013). The conversational intelligibility score was significantly improved with the PP and KAT than without PP and KAT (p＝0.024). These results suggest that speech function can be improved in patients with hard tissue defects with segmental mandibulectomy using both a PP and a KAT. The nature of the design of the PP and that of the KAT will allow these prostheses to address a wide range of tissue defects.

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Event date： 2016

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Event date： 2016

Language：English  

We report a case involving a young female patient with severe mandibular retrognathism accompanied by mandibular condylar deformity that was effectively treated with Le Fort I osteotomy and two genioplasty procedures. At 9 years and 9 months of age, she was diagnosed with Angle Class III malocclusion, a skeletal Class II jaw relationship, an anterior crossbite, congenital absence of some teeth, and a left-sided cleft lip and palate. Although the anterior crossbite and narrow maxillary arch were corrected by interceptive orthodontic treatment, severe mandibular hypogrowth resulted in unexpectedly severe mandibular retrognathism after growth completion. Moreover, bilateral condylar deformities were observed, and we suspected progressive condylar resorption (PCR). There was a high risk of further condylar resorption with mandibular advancement surgery;. therefore, Le Fort I osteotomy with two genioplasty procedures was performed to achieve counterclockwise rotation of the mandible and avoid ingravescence of the condylar deformities. The total duration of active treatment was 42 months. The maxilla was impacted by 7.0 mm and 5.0 mm in the incisor and molar regions, respectively, while the pogonion was advanced by 18.0 mm. This significantly resolved both skeletal disharmony and malocclusion. Furthermore, the hyoid bone was advanced, the pharyngeal airway space was increased, and the morphology of the mandibular condyle was maintained. At the 30-month follow-up examination, the patient exhibited a satisfactory facial profile. The findings from our case suggest that severe mandibular retrognathism with condylar deformities can be effectively treated without surgical mandibular advancement, thus decreasing the risk of PCR.

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Other Link： http://synapse.koreamed.org/DOIx.php?id=10.4041/kjod.2016.46.6.395

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