Language：Japanese   Publisher：(NPO)日本顎変形症学会  

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Language：Japanese   Publisher：(NPO)日本顎変形症学会  

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Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.heliyon.2024.e29445

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Language：Japanese   Publisher：(一社)日本口蓋裂学会  

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Language：Japanese   Publisher：(一社)日本口蓋裂学会  

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Language：Japanese   Publisher：(一社)日本口蓋裂学会  

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Language：Japanese   Publisher：岡山歯学会  

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Authorship：Last author   Language：Japanese   Publishing type：Research paper (scientific journal)  

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Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

Abstract

Cellular communication network factor 2 (CCN2) molecules promote endochondral ossification and articular cartilage regeneration, and circular RNAs (circRNAs), which arise from various genes and regulate gene expression by adsorbing miRNAs, are known to be synthesized from CCN2 in human vascular endothelial cells and other types of cells. However, in chondrocytes, not only the function but also the presence of CCN2-derived circRNA remains completely unknown. In the present study, we investigated the expression and function of CCN2-derived circRNAs in chondrocytes. Amplicons smaller than those from known CCN2-derived circRNAs were observed using RT-PCR analysis that could specifically amplify CCN2-derived circRNAs in human chondrocytic HCS-2/8 cells. The nucleotide sequences of the PCR products indicated novel circRNAs in the HCS-2/8 cells that were different from known CCN2-derived circRNAs. Moreover, the expression of several Ccn2-derived circRNAs in murine chondroblastic ATDC5 cells was confirmed and observed to change alongside chondrocytic differentiation. Next, one of these circRNAs was knocked down in HCS-2/8 cells to investigate the function of the human CCN2-derived circRNA. As a result, CCN2-derived circRNA knockdown significantly reduced the expression of aggrecan mRNA and proteoglycan synthesis. Our data suggest that CCN2-derived circRNAs are expressed in chondrocytes and play a role in chondrogenic differentiation.

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DOI： 10.1007/s12079-023-00782-7

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Other Link： https://link.springer.com/article/10.1007/s12079-023-00782-7/fulltext.html

Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.ajoms.2023.08.015

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Language：Japanese   Publisher：中・四国矯正歯科学会  

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Language：Japanese   Publisher：(NPO)日本口腔科学会  

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Language：Japanese   Publisher：(NPO)日本顎変形症学会  

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Publishing type：Research paper (scientific journal)   Publisher：Wiley  

DOI： 10.1002/osi2.1186

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Language：Japanese   Publisher：(一社)日本口蓋裂学会  

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Language：Japanese   Publisher：(一社)日本口蓋裂学会  

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Language：Japanese   Publisher：(一社)日本口蓋裂学会  

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Language：English  

Appropriate operations in severe anterior open bite (AOB) cases are extremely complicated to perform because of the multiple surgical procedures involved, the difficulty of predicting posttreatment aesthetics, and the high relapse rate. We herein report a 16-year-old girl with skeletal Class II, severe AOB malocclusion, and crowding with short roots, and aesthetic and functional problems. Four-piece segmental Le Fort I osteotomy with horseshoe osteotomy was performed for maxillary intrusion, and bilateral sagittal split ramus osteotomy (SSRO) and genioplasty were performed for mandibular advancement. The malocclusion and skeletal deformity were significantly improved by the surgical orthodontic treatment. Functional and aesthetic occlusion with an improved facial profile was established, and no further root shortening was observed. Acceptable occlusion and dentition were maintained after a two-year retention period. This strategy of surgical orthodontic treatment with a complicated operative procedure might be effective for correcting certain severe AOB malocclusion cases.

DOI： 10.18926/AMO/64369

PubMed

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：OKAYAMA UNIV MED SCHOOL  

Medication-related osteonecrosis of the jaw (MRONJ) is a side effect in patients taking bone-modifying agents (BMAs), which are highly beneficial for treating osteoporosis and cancer. Bisphosphonates are prescribed to treat secondary osteoporosis in patients with rheumatoid arthritis (RA). We recently encountered two unusual cases of intraoral ONJ in RA patients who had not been treated with a BMA and did not have features of methotrexate-associated lymphoproliferative disorder. Their ONJ stage II bone exposures were treated by conservative therapy, providing good prognoses. These cases indicate that ONJ can occur in RA patients not treated with bisphosphonates. Several risk factors are discussed.

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Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.ajoms.2023.01.005

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Language：Japanese   Publisher：(公社)日本口腔外科学会  

79歳男性。既往として40年前に右下顎歯肉癌に対し手術と放射線治療が行われていた。今回、右下顎部の疼痛ならびに開口障害を主訴に、近在の歯科医院より精査目的で当科へ紹介となった。画像所見、生検結果を踏まえて、右下顎歯肉癌の再発と診断され、患者の全身状態、希望よりQUAD shotによる緩和的放射線治療が行われた。その結果、QUAD shotとの併用放射線増感剤にPTXを選択し、1コース終了時より腫瘍は縮小し、疼痛の改善傾向がみられた。更に3コース終了後にはオピオイドを中止し、NSAIDsのみで日常生活を過ごせるようになり、摂食機能の改善で食事量の増加から体重減少や低栄養が改善された。最終的には患者はQOLを維持したまま最期を迎えることができた。

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J01073&link_issn=&doc_id=20230201450002&doc_link_id=10.5794%2Fjjoms.69.9&url=https%3A%2F%2Fdoi.org%2F10.5794%2Fjjoms.69.9&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Language：Japanese   Publisher：(一社)日本口蓋裂学会  

一社・日本口蓋裂学会では,学術調査委員会の2020年度の事業として,2019年1年間の会員施設における新規患者について臨床的検討を行った。49施設より965例の登録があり,以下の結果を得た。1)症型別では辰裂110例(11.4%),唇顎裂206例(21.3%),唇顎口蓋裂388例(40.2%),口蓋裂193例(20.0%),粘膜下口蓋裂52例(5.4%),その他16例(1.7%)であった。2)罹患側では左側368例(52.2%),右側183例(26.0%),両側性160例(22.7%)。両側性は唇裂で少なく,唇顎口蓋裂で他の症型に比べて多かった。3)性別では女性432例(44.8%),男性533例(55.2%)。多くの症型で男性が多い中,口蓋裂では若干であるが,女性の方が多かった。4)出生時体重では,粘膜下口蓋裂で他の症型よりも低体重であった。5)出生前診断では,外表に変化のある口唇裂を含む症型で50%程度であった。6)両親の年齢では,全体に父親が母親よりも若干高年齢であったが症型間に差はなかった。7)血族内での出生では,いずれの症型も6～8%をしめていた。8)併発疾患および9)症候群,染色体異常については,口蓋裂および粘膜下口蓋裂児において頻度が高かった。併発疾患については,1例で複数の併発がみられる場合が多かった。なお,症型間で統計処理(カイ二乗検定)を行い,性差,罹患側,生下時体重,併発疾患,症候群・染色体異常において有意差(p<0.05)を認めた。以上,1年間に出生した日本人の口唇裂・口蓋裂児の多数例の検討から有意義なデータが得られた。(著者抄録)

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J01071&link_issn=&doc_id=20221208300004&doc_link_id=10.11224%2Fcleftpalate.47.210&url=https%3A%2F%2Fdoi.org%2F10.11224%2Fcleftpalate.47.210&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Language：Japanese   Publisher：(公社)日本矯正歯科学会  

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Publishing type：Research paper (scientific journal)   Publisher：Wiley  

DOI： 10.1111/1348-0421.12944

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Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/1348-0421.12944

Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND: We investigated and compared the osteogenic potential and bone regeneration capacities of dedifferentiated fat cells (DFAT cells) and adipose-derived stem cells (ASCs). METHOD: We isolated DFAT cells and ASCs from GFP mice. DFAT cells were established by a new culture method using a mesh culture instead of a ceiling culture. The isolated DFAT cells and ASCs were incubated in osteogenic medium, then alizarin red staining, alkaline phosphatase (ALP) assays, and RT-PCR (for RUNX2, osteopontin, DLX5, osterix, and osteocalcin) were performed to evaluate the osteoblastic differentiation ability of both cell types in vitro. In vivo, the DFAT cells and ASCs were incubated in osteogenic medium for four weeks and seeded on collagen composite scaffolds, then implanted subcutaneously into the backs of mice. We then performed hematoxylin and eosin staining and immunostaining for GFP and osteocalcin. RESULTS: The alizarin red-stained areas in DFAT cells showed weak calcification ability at two weeks, but high calcification ability at three weeks, similar to ASCs. The ALP levels of ASCs increased earlier than in DFAT cells and showed a significant difference (p < 0.05) at 6 and 9 days. The ALP levels of DFATs were higher than those of ASCs after 12 days. The expression levels of osteoblast marker genes (osterix and osteocalcin) of DFAT cells and ASCs were higher after osteogenic differentiation culture. CONCLUSION: DFAT cells are easily isolated from a small amount of adipose tissue and are readily expanded with high purity; thus, DFAT cells are applicable to many tissue-engineering strategies and cell-based therapies.

DOI： 10.3390/ijms222212392

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Language：English  

We herein report the case of a 19-year-old female with a transverse discrepancy, skeletal Class II malocclusion, severe crowding with concerns of classic-type Ehlers-Danlos syndrome (EDS), aesthetics problems and functional problems. The main characteristics of classic EDS are loose-jointedness and fragile, easily bruised skin that heals with peculiar "cigarette-paper" scars. The anteroposterior and transverse skeletal discrepancies can generally be resolved by maxilla repositioning and mandibular advancement surgery following pre-surgical orthodontic treatment. However, this patient was treated with orthodontic camouflage but not orthognathic surgery because of the risks of skin bruising, poor healing and a temporomandibular disorder. A satisfactory dental appearance and occlusion were achieved after camouflage treatment with orthodontic anchor screws and the use of Class II elastics, including the preservation of the stomatognathic functions. Acceptable occlusion and dentition were maintained after a two-year retention period. This treatment strategy of orthodontic camouflage using temporary anchorage, such as anchor screws and Class II elastics, may be a viable treatment option for skeletal malocclusion patients with EDS.

DOI： 10.18926/AMO/61902

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Language：English   Publishing type：Research paper (scientific journal)  

OBJECTIVES: Anti-osteoclastic treatments for breast cancer occasionally cause medication-related osteonecrosis of the jaw. Moreover, elevated glycolytic activity, which is known as the Warburg effect, is usually observed in these breast cancer cells. Previously, we found that cellular communication network factor 2 (CCN2) production and glycolysis enhanced each other in chondrocytes. Here, we evaluated the interplay between CCN2 and glycolysis in breast cancer cells, as we suspected a possible involvement of CCN2 in the Warburg effect in highly invasive breast cancer cells. METHODS: Two human breast cancer cell lines with a distinct phenotype were used. Glycolysis was inhibited by using 2 distinct compounds, and gene silencing was performed using siRNA. Glycolysis and the expression of relevant genes were monitored via colorimetric assays and quantitative RT-PCR, respectively. RESULTS: Although CCN2 expression was almost completely silenced when treating invasive breast cancer cells with a siRNA cocktail against CCN2, glycolytic activity was not affected. Notably, the expression of glycolytic enzyme genes, which was repressed by CCN2 deficiency in chondrocytes, tended to increase upon CCN2 silencing in breast cancer cells. Inhibition of glycolysis, which resulted in the repression of CCN2 expression in chondrocytic cells, did not alter or strongly enhanced CCN2 expression in the invasive and non-invasive breast cancer cells, respectively. CONCLUSIONS: High CCN2 expression levels play a critical role in the invasion and metastasis of breast cancer. Thus, a collapse in the intrinsic repressive machinery of CCN2 due to glycolysis may induce the acquisition of an invasive phenotype in breast cancer cells.

DOI： 10.1016/j.job.2020.07.001

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Language：Japanese   Publisher：(公社)日本口腔外科学会  

症例は3ヵ月男児で、左側唇口蓋裂を認め、出生後早期の染色体G-banding検査にて46,XY,t(11;22)(q23.3;q11.2)と診断された。口蓋裂一貫治療目的に当科を紹介受診した。初診時にホッツ床作製のための印象採得を行い、生後3ヵ月からホッツ床による顎誘導ならびに哺乳の改善を行った。生後5ヵ月目に全身麻酔下にて口唇形成術を施行し、口蓋裂に対しては2段階による口蓋形成術を行うものとし、初回は1歳3ヵ月時に軟口蓋形成術(Furlow法)を行い、1歳11ヵ月で2回目となる硬口蓋閉鎖術を施行した。術後経過は良好であり、2歳2ヵ月から言語聴覚士による発達検査、言語治療を開始した。鼻咽腔閉鎖機能不全や構音障害はみられず、定期的な経過観察を行っている。現在5歳8ヵ月で反対咬合を認めている。

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J01073&link_issn=&doc_id=20200828330010&doc_link_id=130007928053&url=https%3A%2F%2Fci.nii.ac.jp%2Fnaid%2F130007928053&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_1.gif

Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND/AIM: Hepatitis B core (HBc) antibody positivity indicates a history of hepatitis B virus (HBV) infection and latent infection. PATIENTS AND METHODS: We conducted a retrospective case-control study of 512 and 495 head and neck cancer (HNC) and non-HNC patients treated at the Okayama University Hospital, Head and Neck Cancer Center from 2008-2017. Demographic data and risk factors that might affect HNC diagnosis were analyzed to assess their effects. RESULTS: Cancer diagnosis was found to correlate with HBc antibody positivity [odds ratio (OR)=1.50, 95% confidence interval (CI)=1.09-2.08], smoking (OR=3.03, 95%CI=2.16-4.25), and a previous history of cancer (OR=4.12, 95%CI=2.79-6.09). The HBs antigen positivity rate in both groups was very close to that observed in the general Japanese population. The HBc antibody positivity rate was very high only in the HNC group. CONCLUSION: HBc antibody positivity and HNC are epidemiologically correlated.

DOI： 10.21873/anticanres.14209

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Language：English  

OBJECTIVE: This report describes the case of a male patient with a complete unilateral cleft lip and palate who presented with midface deficiency and an anteroposteriorly constricted maxilla. DESIGN: Case report Interventions: Correction involved anterior distraction of the segmented maxilla. RESULTS: The present case demonstrates that elongation of the maxilla with anterior distraction is an effective way to develop a proper dental arch, correct anterior and posterior crowding, and improve a midface deficiency.

DOI： 10.1177/1055665618821831

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Authorship：Last author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

Abstract

Intermittent parathyroid hormone (PTH) administration is known to promote bone healing after surgical procedures. However, the mechanism and influence of PTH on the mineral and collagen quality of the jaw are not well understood. Most studies have focused on analyzing the bone density and microstructure of the mandible, and have insufficiently investigated its mineral and collagen quality. Oxidative stress activates osteoclasts, produces advanced glycation end products, and worsens mineral and collagen quality. We hypothesized that PTH induces oxidation and affects the mineral and collagen quality of newly formed mandibular bone. To test this, we examined the mineral and collagen quality of newly formed mandibular bone in rats administered PTH, and analyzed serum after intermittent PTH administration to examine the degree of oxidation. PTH administration reduced mineralization and worsened mineral and collagen quality in newly formed bone. In addition, total anti-oxidant capacity in serum was significantly decreased and the oxidative-INDEX was increased among PTH-treated compared to vehicle-treated rats, indicating serum oxidation. In conclusion, intermittent administration of PTH reduced mineral and collagen quality in newly formed mandibular bone. This effect may have been induced by oxidation.

DOI： 10.1038/s41598-019-44389-8

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Other Link： https://www.nature.com/articles/s41598-019-44389-8

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japanese Society of Jaw Deformities  

DOI： 10.5927/jjjd.29.295

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Language：Japanese   Publisher：岡山歯学会  

二卵性双生児で、一人は粘膜下口蓋裂、一人は先天性鼻咽腔閉鎖不全症を伴った22q11.2欠失症候群の症例を報告した。二卵性双生児の兄:5歳時に鼻咽腔閉鎖不全を指摘され、当院耳鼻咽喉科に紹介となった。特異的顔貌を認めたため、染色体検査を行い22q11.2欠失症候群と診断された。粘膜下口蓋裂に対して口蓋形成術(Furlow法)を施行し、その後は定期的に言語訓練を行うこととなった。二卵性双生児の弟:5歳時に鼻咽腔閉鎖不全を指摘され、兄とともに当院耳鼻咽喉科に紹介となった。軟口蓋挙上装置を装着し、言語訓練を行った。一旦来院が途絶えていたが再来院され、言語訓練の重要性を十分に説明した。その後は定期的に言語訓練を施行している。

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Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

DOI： 10.1007/s00221-018-5377-1

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Other Link： http://link.springer.com/content/pdf/10.1007/s00221-018-5377-1.pdf

Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCIENCE BV  

Impacted primary teeth can be caused by odontogenic tumors such as odontomas, cystic diseases such as dentigerous and eruption cysts, and fibrous hyperplasia of the gingiva, while elimination of those causes reportedly results in normal eruption of primary teeth. We describe the course of a child from the age of 1 year until 4 years 10 months who had primary tooth eruption failure and was treated with dental methods. Although primary teeth expected to spontaneously erupt were followed, there were several on the left side that remained unerupted. We performed a left maxillary and mandibular gingivectomy to closely examine the cause of eruption delay and tooth germ dislocation, as well as attempt to induce eruption of the primary teeth. Based on histopathological results, the diagnosis was fibroma. Surgical procedures did not result in clear improvement of eruption failure. In order to improve masticatory function and aesthetics, the child was fixed with an artificial denture for all primary teeth not expected to erupt. (C) 2018 Japanese Society of Pediatric Dentistry. Published by Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.pdj.2018.09.002

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OBJECTIVES: To evaluate the effects of maxillary anterior segmental distraction osteogenesis (MASDO) in patients with cleft lip and palate (CLP) and to identify risk factors for increased relapse. DESIGN: A retrospective study. PATIENTS: Thirty-one Japanese patients with CLP who underwent MASDO were eligible for study inclusion. MAIN OUTCOME MEASURES: We evaluated lateral cephalograms obtained before (T1), at 3 months (T2), and at 1 year (T3) after MASDO, and measured changes from T1 to T2 (δT1T2), from T2 to T3 (δT2T3), and from T1 to T3 (δT1T3). We also evaluated the risk factors associated with an increased relapse. RESULTS: Overall (δT1T3), MASDO improved retrusion of the maxilla. We measured a significant advancement (6.1 mm) of the anterior maxillary segment in δT1T2 (A-McNamara classification) and increases in the overjet and the SNA, ANB, and nasolabial angles. However, skeletal relapse was evident in δT2T3, and the median percentage of relapse was 10%. To explore the risk factors, we subdivided patients with a δT1T2 of >5 mm into 2 groups based on the percentage of relapse (>15% vs ≤15%). There were significant differences between these groups in the vertical positions of the anterior nasal spine and point A, and the angle formed by the SN and palatal planes (SNPP), suggestive of intraoperative counterclockwise rotation of the maxilla. CONCLUSIONS: MASDO is effective for correcting midfacial deficiencies, but counterclockwise rotation of the maxilla during surgery may cause relapse.

DOI： 10.1177/1055665618758692

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Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.bjoms.2018.08.003

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Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.ijom.2018.02.002

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Authorship：Last author   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.ajoms.2017.12.005

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCIENCE BV  

Odontomas are generally encountered in permanent dentition and rarely seen in primary dentition. These lesions are regarded as essentially benign, though they often cause disturbances in eruption of the associated tooth. We present clinical findings and management of 3 cases of odontomas that occurred in primary dentition, including a 3-year-old girl referred for examination of an unerupted left upper primary canine, a 6-year-old boy with an unerupted left lower second primary molar, and a 5-year-old girl who was presented with an unerupted right upper second primary molar. In all cases, periapical and panoramic radiography revealed a radio-opaque mass surrounded by a narrow radiolucent space located above the crown of the unerupted tooth. Each was diagnosed as a compound odontoma interfering with eruption of a primary tooth and surgical removal was performed under general anesthesia for all patients, with the final diagnosis based on histological findings. Following surgery, the primary canine in Case 1 spontaneously erupted, while a space maintenance appliance was applied in Case 2 and 3. It is important to recognize that an odontoma can appear in primary dentition, though the incidence is quite low. Early detection and removal of an odontoma associated with an impacted primary tooth is necessary for optimal dentition. (C) 2017 Published by Elsevier Ltd on behalf of Japanese Society of Pediatric Dentistry.

DOI： 10.1016/j.pdj.2017.10.001

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Publishing type：Research paper (scientific journal)   Publisher：Informa UK Limited  

DOI： 10.1080/00207454.2017.1381697

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Language：English   Publishing type：Research paper (scientific journal)  

The CCN family consists of 6 genes in the mammalian genome and produces multifunctional proteins involved in a variety of biological processes. Recent reports indicate the profound roles of CCN2 in energy metabolism in chondrocytes, and Ccn2 deficiency is known to alter the expression of 2 other family members including Ccn3. However, almost nothing is known concerning the regulation of the CCN family genes by energy metabolism. In order to gain insight into this critical issue, we initially and comprehensively evaluated the effect of inhibition of glycolysis on the expression of all of the CCN family genes in chondrocytic cells. Upon the inhibition of a glycolytic enzyme, repression of CCN2 expression was observed, whereas CCN3 expression was conversely induced. Similar repression of CCN2 was conferred by the inhibition of aerobic ATP production, which, however, did not induce CCN3 expression. In contrast, glucose starvation significantly enhanced the expression of CCN3 in those cells. The results of a reporter gene assay using a molecular construct containing a CCN3 proximal promoter revealed a dose-dependent induction of the CCN3 promoter activity by the glycolytic inhibitor in chondrocytic cells. These results unveiled a critical role of glycolytic activity in the regulation of CCN2 and CCN3, which activity mediated the mutual regulation of these 2 major CCN family members in chondrocytes.

DOI： 10.1007/s12079-017-0420-8

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Language：English   Publishing type：Research paper (scientific journal)  

Background/purpose: Few studies have investigated the possibility that bisphosphonate-related osteonecrosis of the jaw (BRONJ) might reflect an immune response; however, gamma delta T cells have been shown to significantly decline in the blood of BRONJ patients. Additionally, there have been some reports of teriparatide usage for the treatment of BRONJ. In this study, we compared the effects of zoledronate and teriparatide on lymphocyte populations and inflammatory cytokine production in mice. Materials and methods: Thirty female ICR mice were divided into three groups (n = 10 each): a vehicle, a zoledronate, and a teriparatide group. Drugs were administered for 8 weeks in each group. Lymphocytes in the blood and thymus were analyzed and femurs were used for histological observation and lymphocytes analysis of bone marrow. Cytokines were measured in separated serum using Milliplex® multiplex immunoassay analysis. Results: Zoledronate decreased the T cell number in the bone marrow. Additionally, serum levels of interleukin (IL)-2, IL-7, IL-12, IL-15 and RANTES, which are cytokines that affect T cell activation, differentiation and/or proliferation, were significantly lower in zoledronate treated mice. Conversely, teriparatide treatment induced an increase in gamma delta T cells in peripheral blood. Conclusion: Gamma delta T cells in the bone marrow are expected to decrease with zoledronate treatment and increase with teriparatide treatment. If BRONJ involves a loss of gamma delta T cells in the circulation or bone marrow, then the increase in gamma delta T cells that is induced by teriparatide may account for its ability to resolve BRONJ.

DOI： 10.1016/j.jds.2017.03.007

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DOI： 10.18926/AMO/55589

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Language：Japanese   Publisher：(公社)日本口腔外科学会  

症例は21歳女性で、13年前に左側頬部の腫瘤を自覚したが確定診断には至らなかった。左側頬部に鈍痛を覚えるようになり、腫瘤の増大を認めた。左側頬粘膜は表面正常で、触診にて咬筋相当部に可動性で軽度の圧痛を伴う30mm大の骨様硬の病変を触知した。単純CT画像では、左側狡筋は右側と比較し腫大し、内部に長径22mm大、外形不整な高吸収域を認めた。病変内部に長径3〜6mm大の複数の類円形石灰物を認めた。造影CT画像では、高吸収域に不均一な造影効果を認め、造影性の高い領域では血管腔と同程度の高い造影性を示した。腫瘤内石灰化物の多くは内部に核を有し、層板状構造に近い性状であった。MRI所見では、病変内部はT1強調画像では低信号から筋と同程度の不均一な信号強度、T2強調画像では低信号から高信号の不均一な信号強度を呈し、石灰化物に相当する部分はほぼ無信号を呈した。全身麻酔下で口腔内より腫瘤の摘出術を施行した。現在、術後3年経過しているが、再発はなく経過良好である。摘出標本の病理組織学的診断は静脈石を伴った静脈奇形であった。

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2017&ichushi_jid=J01073&link_issn=&doc_id=20171130350014&doc_link_id=10.5794%2Fjjoms.63.593&url=https%3A%2F%2Fdoi.org%2F10.5794%2Fjjoms.63.593&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Language：English   Publishing type：Research paper (scientific journal)  

Platinum-based chemotherapy plus cetuximab represents the first-line treatment for recurrent or metastatic squamous cell carcinoma of the head and neck. The most common adverse events associated with cetuximab are infusion reactions and skin reactions, and a risk of venous thromboembolic events has also recently been reported in association with cetuximab. It is well known that thrombosis is a common complication of malignancy, and represents the second most frequent cause of mortality in cancer patients. The present study reports the case of a 79-year-old man who presented with lung and liver metastases from tongue squamous cell carcinoma, for which platinum-based chemotherapy plus cetuximab was administered. After 1 cycle, the patient showed rapid growth of a left ventricular (LV) thrombus, despite ongoing antiplatelet therapy for an old myocardial infarction. Anticoagulant therapy was administered to treat the LV thrombus, which resolved within 1 week. To the best of our knowledge, this represents the first reported case of rapidly occurring LV thrombus associated with platinum-based chemotherapy plus cetuximab. Platinum-based chemotherapy plus cetuximab may be associated with a higher risk of embolic thrombus.

DOI： 10.3892/mco.2017.1393

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Authorship：Last author   Publishing type：Research paper (scientific journal)   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

DOI： 10.5794/jjoms.63.506

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ALLIANCE COMMUNICATIONS GROUP DIVISION ALLEN PRESS  

This report describes a case of successful orthodontic treatment using maxillary anterior segmental distraction osteogenesis with an internal maxillary distractor and bilateral sagittal split ramus osteotomy in a girl with cleft lip and palate. A 16-year-old girl with unilateral cleft lip and palate exhibited midface retrusion because of growth inhibition of the maxillary complex and mandibular excess. After the presurgical orthodontic treatment, 6.0-mm advancement of the maxillary anterior segment and 4.0-mm set back of the mandible were performed. After a retention period, the patient's midface convexity was greatly improved and the velopharyngeal competence was preserved without relapse.

DOI： 10.1597/14-326

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Publishing type：Research paper (scientific journal)   Publisher：Wiley  

DOI： 10.1002/ccr3.751

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Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

DOI： 10.1007/s11064-016-2003-0

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Other Link： http://link.springer.com/article/10.1007/s11064-016-2003-0/fulltext.html

Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.ajoms.2016.03.009

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：SPANDIDOS PUBL LTD  

Odontogenic tumors and cysts, arising in the jawbones, grow by resorption and destruction of the jawbones. However, mechanisms underlying bone resorption by odontogenic tumors/cysts remain unclear. Odontogenic tumors/cysts comprise odontogenic epithelial cells and stromal fibroblasts, which originate from the developing tooth germ. It has been demonstrated that odontogenic epithelial cells of the developing tooth germ induce osteoclastogenesis to prevent the tooth germ from invading the developing bone to maintain its structure in developing bones. Thus, we hypothesized that odontogenic epithelial cells of odontogenic tumors/cysts induce osteoclast formation, which plays potential roles in tumor/cyst outgrowth into the jawbone. The purpose of this study was to examine osteoclastogenesis by cytokines, focusing on transforming growth factor-beta (TGF-beta), produced by odontogenic epithelial cells. We observed two pathways for receptor activator of NF-kappa B ligand (RANKL) induction by keratocystic odontogenic tumor fluid: the cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) pathway through interleukin-1 alpha (IL-1 alpha) signaling and non-COX-2/PGE2 pathway through TGF-beta receptor signaling. TGF-beta 1 and IL-1 alpha produced by odontogenic tumors/cysts induced osteoclastogenesis directly in the osteoclast precursor cells and indirectly via increased RANKL induction in the stroma.

DOI： 10.3892/ijo.2016.3548

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ALLIANCE COMMUNICATIONS GROUP DIVISION ALLEN PRESS  

The present report describes a male patient with a unilateral cleft lip and palate who presented with midfacial anteroposterior and transverse deficiency. Correction involved a two-stage surgical-orthodontic approach: asymmetric anterior distraction of the segmented maxilla followed by two-jaw surgery (LeFort I and bilateral sagittal splitting ramus osteotomies). The present case demonstrates that the asymmetric elongation of the maxilla with anterior distraction is an effective way to correct a transversely distorted alveolar form and midfacial anteroposterior deficiency. Furthermore, successful tooth movement was demonstrated in the new bone created by distraction.

DOI： 10.1597/14-322

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DOI： 10.1016/j.reth.2016.02.006

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DOI： 10.1093/jscr/rjw011

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Objective: 1,4-Dihydroxy-2-naphthoic acid (DHNA) is the main component of the metabolic products after fermentation by Propionibacterium freudenreichii ET-3. In this study, DHNA, vitamin K2 (VK2), and risedronate (Ris) were administered to ovariectomized (OVX) mice to ascertain their suppressive effects on bone mass reduction. Methods: Fifty mice were divided into five groups: Sham, OVX, DHNA, VK2, and Ris groups. The drugs were administered daily for 8 weeks. Subsequently, blood was collected from the orbital venous plexus. The bilateral femurs and L5 lumbar vertebra were excised. To determine the effects of the drugs, we performed histomorphometric analyses of the left femur and L5 by micro-CT, biochemical analyses of serum samples, and histological analyses of the right femur. Results: The results for the total bone mineral density, bone volume density, trabecular thickness, trabecular number, trabecular separation, and histological analyses showed that bone resorption was improved in the DHNA and Ris groups compared with the OVX group. Furthermore, the biochemical analyses revealed that the production of inflammatory cytokines was suppressed in the DHNA and Ris groups. Conclusions: The present findings show that DHNA suppresses the bone mass reduction in OVX mice, suggesting that it could be an alternative treatment for postmenopausal osteoporosis.

DOI： 10.1016/j.ajoms.2015.07.001

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Authorship：Last author   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.ajoms.2015.02.002

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Publishing type：Research paper (scientific journal)   Publisher：Ovid Technologies (Wolters Kluwer Health)  

DOI： 10.1097/scs.0000000000002127

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCIENCE INC  

Objective: The antilingular prominence (AP) is a well-known landmark used during planning of intraoral vertical ramus osteotomy (IVRO) in order to prevent inferior alveolar nerve (IAN) injury, but the location of this landmark is not always clear. In this study, we analyzed the anatomical relationship between the mandibular foramen (MF) and the lateral surface shape of the mandibular ramus for use during IVRO.Patients and methods: We retrospectively analyzed 276 mandibular halves in 67 patients with mandibular deformity and 71 patients without deformity imaged at our department from April 2003 to March 2014. We defined 17 points on the mandibular ramus, and examined the anatomical relationships using multiplanar reconstruction (MPR) images and three-dimensional computed tomography (3DCT) created from preoperative CT data.Results: The prevalence of the AP was 57.6% (159/276) of all cases. The MF was located inferior to the AP in all cases; it was posterior to the AP in 50.3% (80/159) of cases and the sigmoid notch (SN) in 24.6% (68/276) of cases. The minimum horizontal distance between the mandibular posterior ramus border and the MF was 9.28 mm in all cases.Conclusion: The AP cannot always serve as a reference point to prevent IAN damage during IVRO. The osteotomy incision should be placed within 9 mm of the posterior mandibular ramus border in order to prevent intraoperative IAN damage. However, preoperative review of planned osteotomy incisions is necessary in every case. (c) 2014 Asian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAMI. Published by Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.ajoms.2014.11.007

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ALLIANCE COMMUNICATIONS GROUP DIVISION ALLEN PRESS  

This case report presents the management of a female patient with unilateral cleft lip and palate presenting with skeletal Class III malocclusion and a narrow upper dental arch with a midline deviation. The treatment plan involved asymmetric transverse distraction osteogenesis of the maxilla to make the upper dental midline coincident with the facial midline. After the treatment, a good facial profile and a close intercuspation of teeth were achieved. Occlusion remained stable with normal overjet and overbite after 2-year retention.

DOI： 10.1597/13-278

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：OKAYAMA UNIV MED SCHOOL  

This article reports the case of a 44-year-old male with skeletal Class III, Angle Class III malocclusion and unilateral crossbite with concerns about obstructive sleep apnea syndrome (OSAS), esthetics and functional problems. To correct the skeletal deformities, the maxilla was anteriorly repositioned by employing LeFort I osteotomy following pre-surgical orthodontic treatment, because a mandibular setback might induce disordered breathing and cause OSAS. After active treatment for 13 months, satisfactory occlusion was achieved and an acceptable facial and oral profile was obtained. In addition, the apnea hypopnea index (AHI) decreased from 18.8 preoperatively to 10.6 postoperatively. Furthermore, after a follow-up period of 7 months, the AHI again significantly decreased from 10.6 to 6.2. In conclusion, surgical advancement of the maxilla using LeFort I osteotomy has proven to be useful in patients with this kind of skeletal malocclusion, while preventing a worsening of the OSAS.

DOI： 10.18926/AMO/53525

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Other Link： http://orcid.org/0000-0002-4419-9643

Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

DOI： 10.1007/s11064-015-1555-8

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Other Link： http://link.springer.com/article/10.1007/s11064-015-1555-8/fulltext.html

Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

DOI： 10.1007/s10571-014-0137-7

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Other Link： http://link.springer.com/article/10.1007/s10571-014-0137-7/fulltext.html

Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

DOI： 10.1007/s00221-015-4203-2

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Other Link： http://link.springer.com/article/10.1007/s00221-015-4203-2/fulltext.html

Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

DOI： 10.1007/s11064-014-1484-y

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Other Link： http://link.springer.com/article/10.1007/s11064-014-1484-y/fulltext.html

Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

Mesothelioma is a rare neoplasm that arises from the pleura or peritoneum. Although malignant mesothelioma is known to spread hematogenously, causing metastasis to various organs, there have been few reports on oral metastasis. The patient was a 75-year-old man who had an elastic soft mass, measuring 38 × 20 mm, in the right upper jaw gingiva. On biopsy the lesion was histopathologically diagnosed as a malignant pleural mesothelioma with metastasis to the upper jaw. The lesion shrank in response to radiotherapy. We have described a case of malignant pleural mesothelioma arising in the upper jaw gingiva. We discuss the related literature and summarize our findings.

DOI： 10.5794/jjoms.61.168

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Other Link： https://jlc.jst.go.jp/DN/JLC/20009068467?from=CiNii

Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

Bilateral chylothorax is a rare complication after radical neck dissection. We report a case of bilateral chylothorax that developed after left radical neck dissection. A 40-year-old man was given a diagnosis of secondary left cervical lymph-node metastasis from left-sided tongue cancer (T1N0M0), and supraomohyoid neck dissection was performed. Since multiple lymph-node metastases had been found, modified radical neck dissection was performed. We ligated the thoracic duct because it ruptured intraoperatively. On the first postoperative day, a chyle leak was diagnosed, and the thoracic duct was ligated again. The chyle leak resolved, but on the fourth postoperative day, the patient complained of dyspnea and chest discomfort. Computed tomographic scans and chest X-ray films showed bilateral pleural effusions. Diagnostic thoracentesis was performed. Milky fluid was aspirated, and chylothorax was diagnosed. We used a conservative management approach, which involved total parenteral nutrition with total enteric rest. Repeated chest X-ray films showed no evidence of pleural effusion, and the patient was started to receive a low-fat diet on the 11th postoperative day. The patient had recovered completely.

DOI： 10.5794/jjoms.61.288

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Other Link： https://jlc.jst.go.jp/DN/JLC/20011890438?from=CiNii

Language：Japanese   Publisher：岡山歯学会  

口腔癌検診研修会基礎コースを修了した歯科医師を対象に、研修会終了後にアンケート調査を行った。2013年に行われた3回の研修会の研修者の合計は46人(3人が2回研修)であった。臨床経験年数は10〜42年(平均23.6年、中央値25年)に比較的長い研修者が多かった。口腔癌症例経験ありは70%に認められ、経験症例数は1〜3例が多かった。口腔癌症例経験者の中で癌の疑いがあると診断して専門機関に紹介した症例が93%と大部分を占めた。しかし、その中で早期癌を診断できた症例は45%に過ぎず、初診時に進行していた症例も46例に認められた。また、紹介が少し遅くなった症例が9%認められたが患者が専門機関をなかなか受診してくれなかった例も1例あった。癌の部位は舌が最も多く41%認められ、下顎歯肉32%、口底13%と続いた。研修会の時間・レベルは概ね適切で、講義・実習・テキストもためになり、今後の臨床に役立つとの回答が得られた。再研修の必要性は91%と多かったが、アドバンスコースの希望者は69%に留まり、ベーシックコースの希望者も22%認められた。また、再研修までの期間は1年の35%を前後にばらつきが認められた。研修者はより実践的に役立つ研修内容を希望していた。

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Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.archoralbio.2014.08.008

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：WILEY-BLACKWELL  

In recent years, artificial biological materials have been commonly used for the treatment of bone tissue defects caused by trauma, tumors, or surgical stress. Although tricalcium phosphate (TCP) is a promising absorbent bone tissue reconstruction biomaterial, it has been reported that its biocompatibility and osteoconductivity depend on its preparation method and sintering temperature. In addition, although it is thought that the microenvironment produced by the extracellular matrix plays an important role in cell growth and differentiation, there have been few studies on how the geometric structure of artificial biological materials affects cells. In the present study, a new honeycomb TCP scaffold containing through-holes with diameters of 300 mm has been developed. The influence of the sintering temperature on the crystal structure and material properties of the honeycomb TCP scaffold was investigated using scanning electron microscopy and X-ray diffraction. Its biocompatibility and osteoconductivity were also evaluated by implantation into experimental animals. It was found that a beta-TCP scaffold sintered at 1200 degrees C exhibited high biocompatibility and osteoconductivity, and when it was loaded with BMP-2, it exhibited both osteoconductivity and osteoinductivity, promoting rapid bone formation in both ectopic and orthotopic areas. It is thus a highly promising bone reconstruction material that is expected to find clinical applications. (C) 2013 Wiley Periodicals, Inc.

DOI： 10.1002/jbm.a.34966

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DOI： 10.1002/jcb.24728

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Publishing type：Research paper (scientific journal)   Publisher：American Society for Microbiology  

ABSTRACT

Periodontitis is an inflammatory disease of polymicrobial origin affecting the tissues supporting the tooth. The oral anaerobic bacterium Porphyromonas gingivalis , which is implicated as an important pathogen for chronic periodontitis, triggers a series of host inflammatory responses that promote the destruction of periodontal tissues. Among the virulence factors of P. gingivalis , hemoglobin receptor protein (HbR) is a major protein found in culture supernatants. In this study, we investigated the roles of HbR in the production of inflammatory mediators. We found that HbR induced interleukin-8 (IL-8) production in the human gingival epithelial cell line Ca9-22. p38 mitogen-activated protein kinase (MAPK) and extracellular signal-related kinase 1/2 (Erk1/2) were activated in HbR-stimulated Ca9-22 cells. Inhibitors of p38 MAPK (SB203580) and Erk1/2 (PD98059) blocked HbR-induced IL-8 production. Additionally, HbR stimulated the translocation of NF-κB-p65 to the nucleus, consistent with enhancement of IL-8 expression by activation of the NF-κB pathway. In addition, small interfering RNA (siRNA) targeting activating transcription factor 2 (ATF-2) or cyclic AMP-response element-binding protein (CREB) inhibited HbR-induced IL-8 production. Moreover, pretreatment with SB203580 and PD98059 reduced HbR-induced phosphorylation of CREB and ATF-2, respectively. Combined pretreatment with an inhibitor of NF-κB (BAY11-7082) and SB203580 was more efficient in inhibiting the ability of HbR to induce IL-8 production than pretreatment with either BAY11-7082 or SB203580 alone. Thus, in Ca9-22 cells, the direct activation of p38 MAPK and Erk1/2 by HbR caused the activation of the transcription factors ATF-2, CREB, and NF-κB, thus resulting in the induction of IL-8 production.

DOI： 10.1128/iai.01140-12

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：CHURCHILL LIVINGSTONE  

Objectives: The purpose of this study was to explore the voice characteristics of patients with mandibular prognathism, and to investigate the effects of mandibular setback surgery on these characteristics using nonlinear dynamics and conventional acoustic analyses.
Materials and methods: Sixteen patients (8 males and 8 females) who had skeletal 3, class III malocclusion without cleft palate, and who underwent a bilateral sagittal split ramus osteotomy (BSSRO), were enrolled. As controls, 50 healthy adults (25 males and 25 females) were enrolled. The mean first LEs (mLE1) computed for each one-second interval, and the fundamental frequency (F0) and frequencies of the first and second formant (F1, F2) were calculated for each Japanese vowel.
Results and conclusions: The mLE1s for /u/ in males, and /o/ in females and the F2s for /i/ and /u/ in males, changed significantly after BSSRO. Class III voice characteristics were observed in the mLE1s for /i/ in both males and females, in the F0 for /a/, /i/, /u/ and /o/ in females, and in the F1 and F2 for /a/ in males, and the F1 for /u/ and the F2 for /i/ in females. Most of these characteristics were preserved after BSSRO. (C) 2013 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.jcms.2012.01.021

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Language：English   Publisher：(公社)日本生化学会  

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Language：Japanese   Publisher：(一社)歯科基礎医学会  

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Bone healing is a complex and multistep process in which the origin of the cells participating in bone repair is still unknown. The involvement of bone marrow-derived cells in tissue repair has been the subject of recent studies. In the present study, bone marrow-derived cells in bone healing were traced using the GFP bone marrow transplantation model. Bone marrow cells from C57BL/6-Tg (CAG-EGFP) were transplanted into C57BL/6 J wild mice. After transplantation, bone injury was created using a 1.0-mm drill. Bone healing was histologically assessed at 3, 7, 14, and 28 postoperative days. Immunohistochemistry for GFP; double-fluorescent immunohistochemistry for GFP-F4/80, GFP-CD34, and GFP-osteocalcin; and double-staining for GFP and tartrate-resistant acid phosphatase were performed. Bone marrow transplantation successfully replaced the hematopoietic cells into GFP-positive donor cells. Immunohistochemical analyses revealed that osteoblasts or osteocytes in the repair stage were GFP-negative, whereas osteoclasts in the repair and remodeling stages and hematopoietic cells were GFP-positive. The results indicated that bone marrow-derived cells might not differentiate into osteoblasts. The role of bone marrow-derived cells might be limited to adjustment of the microenvironment by differentiating into inflammatory cells, osteoclasts, or endothelial cells in immature blood vessels.

DOI： 10.1007/s00223-012-9685-3

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：MOSBY-ELSEVIER  

Delayed tooth eruption can affect the accuracy of orthodontic diagnosis and treatment planning and could delay overall treatment. A girl, aged 7 years 4 months, who had unilateral delayed eruption of several teeth was successfully treated. The evaluation of delayed tooth eruption should be considered by the orthodontist because the role of these teeth can affect the overall treatment of malocclusion. In patients with delayed tooth eruption, careful and accurate diagnosis and treatment planning will allow the orthodontist to start treatment at the proper stage and might reduce the overall orthodontic treatment time. (Am J Orthod Dentofacial Orthop 2013;143:134-9)

DOI： 10.1016/j.ajodo.2011.11.024

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Language：English   Publisher：JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY  

Defensins are generally implicated in the quick resistance of epithelial surfaces to microbials; however, recent reports have indicated that defensins also have unknown purposes in relation to noninfectious diseases. In this study, the localization patterns of anti-microbial peptides, β defensins (BDs), in the tracheal epithelium of male C3H mice under exposure to toluene were analyzed by immunohistochemistry. Mice were exposed one to ten times to toluene for 30 min by nose-only inhalation. Expression of BDs was revealed by immunohistochemistry in serial sections of trachea after the final exposure. Expression of BD-1 was usually observed at almost the same levels in all exposure groups, and expression of BD-2 was observed in the control group; however, the signals for BD-2 decreased gradually with frequency of exposure. In the group exposed ten times, expression of BD-2 decreased to far lower than that of the control group. No expression of BD-3 was detected in any groups. Interestingly, expression of BD-4 increased to the maximum in the group exposed four times and decreased to a level lower than that of the control in the group exposed ten times. The results of the present study indicated that toluene gas might change the expression pattern of BDs in the tracheal epithelial cells. The oscillation of expression of BD-4 was quite characteristic and might contribute to morphological damage in on the epithelial cells.

DOI： 10.1293/tox.26.35

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Other Link： https://jlc.jst.go.jp/DN/JALC/10017550764?from=CiNii

Language：English   Publisher：THE JAPANESE SOCIETY FOR JAW DEFORMITIES  

DOI： 10.5927/jjjd.22.S7

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Other Link： http://search.jamas.or.jp/link/ui/2013185847

Language：Japanese   Publisher：日本再生歯科医学会  

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Language：Japanese   Publisher：岡山歯学会  

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Language：English   Publishing type：Research paper (scientific journal)  

Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare malignant odontogenic tumor arising from odontogenic epithelial remnants within the jawbones. PIOSCC is histopathologically divided into 3 types: solid-type carcinoma, carcinoma derived from a keratocystic odontogenic tumor, and carcinoma derived from an odontogenic cyst. In this article, we report a case of solid-type PIOSCC involving reactive bone formation in the mandible in a 60-year-old female patient together with its histopathological and imaging findings. © 2012 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.oooo.2012.05.019

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Language：Japanese   Publisher：(一社)歯科基礎医学会  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：CHURCHILL LIVINGSTONE  

Objective: This study was undertaken to analyse in detail the morphological features of the philtral dimple and the developmental changes of philtral morphology, including a comparison with patients with a cleft lip.Patients and participants: Fifty-five normal Japanese adults, seventy-five children and fifteen patients with complete unilateral cleft lip were referred for analysis.Design: 3D facial data were acquired with a non-contacting laser scanner. We calculated the desired linear and angular components, defining the features of the philtrum with analysing software.Results: The philtral dimple was morphologically expressed by the two different deepest points in the horizontal and sagittal sectional view, respectively. These decreased with age and did not show any correlation. In contrast, philtral measurements on the X-Y coordinates increased during the course of development. Most of the linear and angular variables in the patients with the cleft lip had exhibited greater values than the normal subjects, reflecting the deformed philtral morphology.Conclusions: To obtain an optimally natural philtral construction accompanied by a symmetrical lip in cleft surgery, it is critical to take into consideration both the geometric features of the philtral depth and age-appropriate morphological features of the philtrum as objective criteria. (C) 2011 European Association for Cranio-Maxillo-Facial Surgery.

DOI： 10.1016/j.jcms.2011.04.019

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：SPRINGER  

Some progress has been made in development of methods to regenerate bone from cultured cells, however no method is put to practical use. Here, we developed methods to isolate, purify, and expand mesenchymal stem cells (MSCs) from mouse compact bone that may be used to regenerate bone in vivo. These cells were maintained in long-term culture and were capable of differentiating along multiple lineages, including chondrocyte, osteocyte, and adipocyte trajectories. We used standard cell isolation and culture methods to establish cell cultures from mouse compact bone and bone marrow. Cultures were grown in four distinct media to determine the optimal composition of culture medium for bone-derived MSCs. Putative MSCs were subjected to flow cytometry, alkaline phosphatase assays, immunohistochemical staining, and several differentiation assays to assess cell identity, protein expression, and developmental potential. Finally, we used an in vivo bone formation assay to determine whether putative MSCs were capable of regenerating bone. We found that compact bone of mice was a better source of MCSs than the bone marrow, that growth in plastic flasks served to purify MSCs from hematopoietic cells, and that MSCs grown in basic fibroblast growth factor (bFGF)-conditioned medium were, based on multiple criteria, superior to those grown in leukemia inhibitory factor-conditioned medium. Moreover, we found that the MSCs isolated from compact bone and grown in bFGF-conditioned medium were capable of supporting bone formation in vivo. The methods and results described here have implications for understanding MSC biology and for clinical purpose.

DOI： 10.1007/s10735-011-9385-8

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The purpose of this study was to determine the accuracy of a new high resolution digital camerabased three-dimensional system called Di3D by comparing with traditional direct anthropometry using digital calipers. The study sample consisted of 20 young adults, 10 male and 10 female. Facial soft tissue landmarks were identified and five linear distances were measured between the landmarks for each subject using the two methods
Di3D camera system and a digital caliper. No statistically significant differences (P &gt
0.05) were found for all five facial soft tissue distances measured by the Di3D camera system and the digital caliper. The magnitude of differences was very small (mean = 0.73 mm). Good congruence was observed between the means derived from the Di3D system and the digital caliper. The overall mean differences of the five measurements with these two methods were small enough to be clinically insignificant. The results show that both methods are concordant and one method can replace the other in clinical use. © 2012 The Hard Tissue Biology Network Association Printed in Japan, All rights reserved.

DOI： 10.2485/jhtb.21.87

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Publishing type：Research paper (scientific journal)   Publisher：Hindawi Limited  

<italic>Objectives</italic>. To clarify the difference between Lyapunov exponents (LEs) for cleft palate (CP) patients with hypernasality versus without hypernasality and to investigate the relationship between their LEs and nasalance scores (NSs).<italic>Material and Methods</italic>. Six CP patients with severe hypernasality (mean age 9.2 years) and six CP patients without hypernasality (mean age 8.0 years) were enrolled. Five Japanese vowels were recorded at 44.1 KHz, and the NSs were measured simultaneously. The mean first LE (mLE₁) from all one-second intervals was computed.<italic>Results</italic>. The mLE₁for /o/ in patients with hypernasality was significantly higher than that in patients without hypernasality. The correlation coefficients between the mLE₁and NS for all vowels were not statistically different.<italic>Conclusion</italic>. The voice signal of /o/ for the patients with hypernasality was more instable than in those without hypernasality. The chaotic phenomenon was independent of nasal resonance in CP voice.

DOI： 10.1155/2012/739523

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Other Link： http://downloads.hindawi.com/journals/ijoto/2012/739523.xml

Language：English   Publishing type：Research paper (scientific journal)   Publisher：CHURCHILL LIVINGSTONE  

DOI： 10.1016/j.bjoms.2010.09.004

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCIENCE BV  

Identification and characterization of local molecules directing the differentiation of chondrocytes to either transient or permanent cartilage are major issues in cartilage biology. Here, we found CCN family protein 3 (CCN3) was abundantly produced in rat developing epiphyseal cartilage. Evaluations in vitro showed that CCN3 repressed epiphyseal chondrocyte proliferation, while promoting matrix production in multiple assays performed. Furthermore, CCN3 enhanced the articular chondrocytic phenotype; whereas it repressed the one representing endochondral ossification. Additionally, the phenotype of growth plate chondrocytes and chondrogenic progenitors also appeared to be affected by CCN3 in a similar manner. These findings suggest a significant role of CCN3 in inducing chondrocytes to articular ones during joint formation. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

DOI： 10.1016/j.febslet.2011.08.024

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：LIPPINCOTT WILLIAMS & WILKINS  

This study was designed to evaluate detailed philtral morphology involving sex and racial differences and to clarify the objective parameters related to subjective judgments regarding the clarity of the philtrum. Fifty-five Japanese and 20 Mexican normal subjects aged 24 to 40 years were recruited, and three-dimensional facial data were acquired using a noncontacting optical surface scanner. The visual classification of the philtral column morphology in Japanese adults using facial photographs revealed that the predominant philtral column shape was different by sex. The three-dimensional anthropometric data showed significant sex differences, which were reflected in the more pronounced visual impression of the philtrum in men. A comparative study between Japanese and Mexican women also revealed certain racial differences. Furthermore, both the philtral depth and central angle of Cupid's bow were extracted as explanatory variables related to the subjective judgments for the clarity of the philtrum. These results suggest that the comprehensive evaluation of philtral morphologic features by three-dimensional analysis is a useful means of identifying the ideal parameters in philtral construction in cleft surgery.

DOI： 10.1097/SCS.0b013e31822e5ebf

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Language：Japanese   Publisher：(公社)日本口腔外科学会  

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Chondrocytes forming articular cartilage are embedded in a vast amount of extracellular matrix having physical stiffness and elasticity, properties that support the mechanical load from bones and enable the flexible movement of synovial joints. Unlike chondrocytes that conduct the growth of long bones by forming the growth plate, articular chondrocytes show suppressed cell proliferation, unless these cells are exposed to pathological conditions such as mechanical overload. In the present study, we found that one of the members of the CCN family, CCN3, was significantly expressed in chondrocytes isolated from the epiphyseal head in developing rat synovial joints. Evaluation of the effect of recombinant CCN3 on those chondrocytes revealed that CCN3 promoted proteoglycan synthesis, whereas this factor repressed the proliferation of the same cells. These results suggest a critical role for CCN3 in the regulation of the biological properties of articular chondrocytes. © The International CCN Society 2011.

DOI： 10.1007/s12079-011-0135-1

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Language：Japanese   Publishing type：Research paper (scientific journal)  

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This study involved a histologic, enzyme histologic, immunohistologic, and three-dimensional microstructure evaluating the extent of osteogenesis and repair in the human alveolar extraction socket achievable with an artificial bone substitute. After tooth extraction in 7 patients, extraction sockets were filled with Mastergraft (15% hydroxyapatite, 85% β-tricalcium phosphate complex). Radiomicrographs and histologic examinations were performed on samples obtained during dental implant placement procedure. On micro-computed tomography, new bone was observed in all collected samples, and osteogenesis was observed to have taken place around the artificial bone substitute. Histologically, active osteogenesis was found throughout the region observed. Addition of new bone around the Mastergraft was observed, and osteoblast-like cells were present. Cells that had partially invaded the artificial bone included tartrate-resistant acid phosphate-positive and CD34-positive cells. These findings indicate that the Mastergraft artificial bone induced osteogenesis in the jawbone and seemed effective for repairing bone defects. Copyright © 2011 by Mutaz B. Habal, MD.

DOI： 10.1097/SCS.0b013e318208bacf

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Journal of Clinical Pediatric Dentistry  

Objective: The purpose of this study was to explore the 3-dimensional (3D) accuracy of magnetic resonance imaging (MRI) on cone-beam computed tomography (CBCT) images after the registration of MRI images on CBCT images. Materials and Methods: Three Japanese adult females volunteered for this study. To transform digital imaging and communication in medicine (DICOM) data derived from MRI and CBCT images into polygon data, five software programs were used. CBCT and MRI images were obtained within one week, and both were registered by the iterative closest point (ICP) method. To assess the accuracy of the composite MRI-CBCT, the measurement errors of the MRI-CBCT were verified. Measurement values were compared using frontal and cephalometric soft-tissue landmarks. Differences were analyzed using the non-parametric Mann-Whitney U test. Results: There were no significant linear measurement errors (P 0.05) when the images were measured from the superimposed MRI-CBCT images. Conclusion: The MRI images attained from MRI-CBCT registration showed accurate 3D linear measurements.

DOI： 10.17796/jcpd.36.2.r7853hp574045414

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer-Verlag Tokyo  

In patients in whom a tracheal tube cannot be inserted through the nostrils due to multiple facial trauma or hypoplasty of the nose, submental orotracheal intubation (SOI) is performed to avoid tracheostomy. We report a new modification for SOI to minimize the risk of apnea. A 20-year-old man was scheduled for sagittal split ramus osteotomy. As the patient had severe hypoplasia of the nose, SOI was planned. Following orotracheal intubation with a spiral tube (first tube), a submental tunnel was surgically created. A second tube that had been confirmed, in advance, to snugly fit into the proximal end of the first tube was passed into the submental tunnel via a polypropylene cylinder and connected between the first tube and the breathing circuit. After careful withdrawal of the second tube through the submental tunnel, the first tube was directly connected to the breathing circuit after removal of the second tube. Although this technique requires additional time, apnea time is minimal even in patients in whom withdrawal of the tracheal tube through the submental tunnel takes time, because the second tube forms a link between the first tube and the breathing circuit, making it possible to ventilate the patient throughout the procedure. © Japanese Society of Anesthesiologists 2011.

DOI： 10.1007/s00540-011-1204-6

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：OKAYAMA UNIV MED SCHOOL  

The term atypical lipomatous tumor (ALT) is synonymous with well-differentiated liposarcoma (WDL). This tumor occurs very rarely in the tongue. Thus, it is difficult to predict its prognosis. Although recurrence of ALT/WDL is thought to be unlikely after complete excision, long-term follow-up is necessary when considering the pathologic conditions of this tumor at other sites. Here, we report a case of an ALT of the tongue, with a review of the literature. A 68-year-old man was referred to our hospital because of a tumor on the left side of his tongue. Upon palpation, the tumor was 12mm in diameter, circumscribed, elastic and hard, well demarcated, movable, and painless. We diagnosed the lesion as a lipoma and extirpated the tumor under local anesthesia. Because the specimen was histopathologically diagnosed as an ALT, as a precaution, we excised an additional 5mm from the area surrounding the original tumor under general anesthesia. Three years after the operation, the tongue demonstrated good healing without paresthesia or dysfunction, and to date there has been no evidence of recurrence.

DOI： 10.18926/AMO/40134

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Herein, we report a very rare case of pilomatricoma in the perioral region. A 27-year old Japanese female was referred to our clinic with a subcutaneous tumor in the angle of the left side of the mouth. The tumor was observed as a subcutaneous well-circumscribed and bony hard mass, without any changes of the skin surface, while a soft radiographic examination revealed a weak calcifying rounded mass. The tumor was extirpated using an intraoral approach, because of patient request. During the operation, the tumor was found to be partly attached to the surface skin, though easily removed from the surrounding tissue. The tumor was a rounded calcifying mass, 13. mm in diameter, and histologically diagnosed as a pilomatricoma. © 2010 Asian Association of Oral and Maxillofacial Surgeons.

DOI： 10.1016/j.ajoms.2009.05.003

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Language：Japanese   Publisher：(一社)日本顎関節学会  

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Language：Japanese   Publisher：(公社)日本口腔外科学会  

症例は45歳女性で、1年前より左側上顎臼歯部に時折違和感を自覚していたが放置した。歯科治療で撮影されたパノラマX線で左側上顎洞内のX線不透過像を指摘された。顔貌は左右対称で、左側上顎眼窩下部に圧痛等の異常所見は認めなかった。左側上顎歯肉部に膨隆や腫脹、発赤等の異常所見を認めなかった。左上6、左上7は電気歯髄診断で生活反応を認めなかった。パノラマX線では左上678相当部の上顎洞底より左側上顎洞内に突出した類円形の塊状のX線不透過像が認められた。CTでは左側上顎洞内に上顎洞底から外向性に突出し上顎洞前壁、側壁、後壁と接する病変を認め、病変の内部のdensityは不均一であった。また、病変内部に歯を認めた。左側上顎骨腫瘍と診断し全身麻酔下に摘出術を施行した。病理組織学的所見は病変の内部に埋伏歯を認め、埋伏歯を取り囲むように塊状の不規則な形態の硬組織が認められた。硬組織はセメント質様、或いは骨様で、線維組織は細胞成分が豊富であった。術後経過は良好で術後6ヵ月現在、再発を認めていない。

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Language：Japanese   Publisher：(NPO)日本口腔科学会  

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2010&ichushi_jid=J01072&link_issn=&doc_id=20100520230002&doc_link_id=%2Fcp8stoma%2F2010%2F005902%2F003%2F0068-0078%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcp8stoma%2F2010%2F005902%2F003%2F0068-0078%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese   Publishing type：Research paper (scientific journal)  

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Language：English   Publisher：11  

DOI： 10.1177/0022034509345998

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AIM: The purpose of this study was to examine morphological changes of the mandibular region using frontal cephalograms following bilateral sagittal split osteotomy (BSSO) for mandibular setback. Furthermore, we compared the stability between screw and plate fixation. METHODS: Pre and postoperative frontal cephalograms were taken of 26 patients. Parameters, Angle "A" which is formed by constructed lines along the mandibular ramus, and mandibular width at the angle were calculated. The subjects were analyzed according to the types of bony fixation, whether by screws or plates. RESULTS: Angle "A" and mandibular angular width of total numbers did not widely change at early period following operation. Late postoperatively, mandibular width of total numbers decreased in conjunction with increasing Angle "A". When comparing the parameters between screw and plate groups, the plate group showed a decrease of Angle "A" as an early change. Late postoperatively, the plate group showed an increase of Angle "A" and a decrease of mandibular width, while the screw group had smaller changes. CONCLUSION: We demonstrate postoperative inclination of mandibular lower ramus towards the facial midline. We suggest that the types of rigid fixation have an influence on frontal skeletal morphology, namely that screw fixation has higher stability.

DOI： 10.1016/j.jcms.2009.04.012

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Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

Epulis osteoplastica is a rare disease. We report a case of giant epulis osteoplastica containing a largesequestrum. A 63-year-old man was referred to our clinic because of a painless swelling on the left mandibularalveolus. Intraoral examination revealed an elastic hard tumor with a normal surface in the left lower molar region.Radiographic examination showed a large radiopaque mass separate from mandibular bone. Gingival tumor excisionwas performed with the patient under general anesthesia. The excised specimen measured 50 X 38 X 28mm and contained the bony mass. Histopathologically, the lesion was diagnosed as epulis osteoplastica with asequestrum. The patient was followed up for 4 years after the operation, without any recurrence.

DOI： 10.5794/jjoms.55.453

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Other Link： https://jlc.jst.go.jp/DN/JALC/00338247726?from=CiNii

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DOI： 10.1097/01.ta.0000245948.68844.00

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Vertical alveolar augmentation by distraction osteogenesis has become a standard pretreatment of dental implants due to the main benefit of lack of donor site complications, and many reports have shown its benefit with various types of alveolar distractors. However, autogenous bone transplantation and/or guided bone regeneration techniques are still the standard treatment for correcting a narrow alveolar ridge because of few commercially available distractors for alveolar widening. In this article, we treated a case by a mesh-plate type of alveolar widening distractor for a narrow posterior mandibular alveolar ridge after extirpation of a large jaw cyst.

DOI： 10.1016/j.tripleo.2008.07.006

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：CHURCHILL LIVINGSTONE  

Nasolabial cysts are rare non-odontogenic cysts that occur beneath the ala nasi, and debate about their complicated, unique pathogenesis continues. It is widely accepted that these lesions originate from the anlage of the nasolacrimal duct; however, some still think that nasolabial cysts arise from fissural cysts. The authors report a patient with a nasolabial cyst who also had a unilateral cleft lip and palate. This unusual finding may indicate a different origin for nasolabial cysts than what has been accepted in the past.

DOI： 10.1016/j.ijom.2008.04.016

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Language：Japanese   Publisher：(NPO)日本口腔科学会  

26歳女。口蓋正中部疼痛を主訴とした。既往としてパニック障害、うつ病があり、25歳時より摂食障害を認め、過食と自己誘発性嘔吐を繰り返していた。右側口蓋に周囲硬結を伴う腫脹を認め、その中央部に壊死を伴う潰瘍を認めて口蓋悪性腫瘍を疑った。MRIでは右側口蓋にびまん性の腫脹を伴う境界明瞭な病変を認め、T1強調像で低信号、T2強調像で高信号を示した。潰瘍の生検を行い壊死性唾液腺炎と診断し、潰瘍にエレース軟膏とプロスタンディン軟膏を混和したガーゼを塗布し、保護床を装着して経過観察を行った。潰瘍は治癒傾向を示したが、生検6日後に左側口蓋に新たな潰瘍が出現した。右側病変と類似していたため同様の処置を行い、1ヵ月後に潰瘍は消失し、また経過観察中に過食や自己誘発性嘔吐も改善した。病理組織学的所見で小唾液腺の広範囲な腺房壊死や導管由来の扁平上皮化生を認めたが、粘液細胞の扁平上皮化生は認めず、腺房細胞周囲での著しい肉芽形成や炎症細胞浸潤も認めなかった。

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2008&ichushi_jid=J01072&link_issn=&doc_id=20080814280010&doc_link_id=%2Fcp8stoma%2F2008%2F005703%2F011%2F0311-0314%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcp8stoma%2F2008%2F005703%2F011%2F0311-0314%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese   Publisher：(公社)日本口腔外科学会  

41歳女。下垂体腺腫と診断され経蝶形骨洞下垂体腫瘍摘出術を受け、以降末端肥大症の改善目的に持続性ソマトスタチンアナログの継続的投与を受けていた。今回、末端肥大症に伴う不正咬合および下顎前歯部歯間離開の改善目的に当科紹介となった。顔貌所見は顔面高および幅ともに大きく、前額部は突出し、眉部、眼窩外側縁は隆起していた。口腔内所見は舌は肥大し、睡眠時にいびきを伴っていた。上顎中切歯間と下顎前歯部に歯間離開を認め、上下顎中切歯ではover jetが-5mm、over biteが1mmを示し、上下第一大臼歯はIII級の対向関係にあった。側面セファロX線規格写真ではトルコ鞍の風船様拡大を認め、セファロ分析では骨格性下顎前突症を示した。末端肥大症に伴う骨格性下顎前突症および巨舌症と診断し、術前矯正治療後、下顎枝矢状分割術による顎矯正手術および舌縮小術を施行した。術後経過は良好で、術後4年4ヵ月のセファロX線写真分析で良好な下顎位と咬合を認めた。

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Publishing type：Research paper (scientific journal)   Publisher：SAGE Publications  

The finding that the vomer plays a crucial role in maxillary growth suggests that the bilateral cleft configuration of unilateral cleft lip and palate (UCLP), in which the vomer is detached from the non-cleft-side secondary hard palate, negatively influences palatal development, and this hypothesis was tested. Sixty persons with complete UCLP, including those with the vomer detached from (n = 30, b-UCLP) and attached to (n = 30, u-UCLP) the secondary hard palate, were analyzed morphologically, with the use of cast models taken at 10 days, 3 mos, and 12 mos of age. The anterio-posterior palatal length at 12 mos of age in those with b-UCLP was significantly shorter than that in those with u-UCLP, by 8.7% (p &lt; 0.05). In addition, palatal width development in the first year in those with b-UCLP was also significantly retarded. These results suggest that the uncommon bilateral cleft subtype in UCLP should be included in the cleft classification.

DOI： 10.1177/154405910808700212

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Other Link： http://journals.sagepub.com/doi/full-xml/10.1177/154405910808700212

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Aim: Peripheral ameloblastoma (PA) is a rare variant of ameloblastoma occurring in the extraosseous region. With regard to the histogenesis of the tumor, two major sources of origin are considered: odontogenic epithelial remnants and the gingival epithelium. In this study, we examined the immunohistochemical profiles of cytokeratins (CKs) and Ki-67 labeling index (LI) of PAs, and discuss the histogenesis and the biologic behavior of the PA. Materials and methods: Eight cases of PA were retrieved from the pathology files of 212 cases of ameloblastoma that had been registered at our hospital. Immunohistochemical staining was performed in seven cases using monoclonal antibodies of six CKs (7, 8, 13, 14, 18, and 19) and Ki-67. Results: All cases of PA expressed CK13, 14, and 19. CK18 was positive staining in six cases, and CK8 in five cases. This staining pattern was similar to that in intraosseous ameloblastomas (IAs). The mean of Ki-67 LI of PAs (1.91%) was significantly lower than that of IAs (4.82%) (P = 0.002). Conclusion: We consider that the PA originates from odontogenic epithelial remnants rather than from the gingival epithelium, and the Ki-67 LI of the tumor is a good prognostic indicator. © 2007 The Authors.

DOI： 10.1111/j.1601-0825.2006.01340.x

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Language：Japanese   Publisher：大阪大学歯学会  

20歳男。上下左右の大臼歯の骨性癒着を主訴とした。口腔内所見では両側上下顎第2小臼歯、第1大臼歯が低位であり、同部で咬合を認めなかった。X線で両側下顎第2小臼歯、第1大臼歯に歯根膜腔を認めず、骨性癒着を疑った。両側上下顎第1大臼歯、第1小臼歯の低位骨性癒着歯と診断し、右側上下顎第1大臼歯と左側上顎第1大臼歯に対しCorticotomyを施行し、顎間ゴムの矯正装置により咬合誘導を行った。しかし、初回の処置だけで移動を確認したのは右側上顎第1大臼歯のみであり、それ以外の2歯については再手術による海綿骨の離断を追加した。残りの左側下顎第1大臼歯に対しては、Single-tooth dento-osseous osteotomyを施行し、顎間ゴムの矯正装置により咬合誘導を行った。4歯とも移動を確認し、術後4ヵ月のX線で歯根膜スペースの拡大から歯牙の脱臼を認め、術後6ヵ月には歯槽骨の良好な治癒状況を認め、左右臼歯部の咬合関係が回復した。

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Language：Japanese   Publisher：(公社)日本口腔外科学会  

1歳2ヵ月、メキシコ人男児。術前所見では右側にTessier No.4顔面裂、左側にNo.5顔面裂(それぞれNo.4 cleft、No.5 cleft)、左側に顎裂部に連続する索状組織を認めた。右眼は開眼不能であり、角膜は肥厚、混濁し、失明していた。生後8ヵ月時に右側斜顔面裂の形成手術、左側の索状組織切除術を施行されたが、審美的・機能的改善が得られなかった。当科入院時、右側披裂部に手術後瘢痕、上唇の披裂を認め、下眼瞼は下方に強く牽引され閉眼不能であった。CTでは右側小眼球症を認め、右側眼窩内容積は左側に比べ狭小であった。右側の骨披裂は乳犬歯相当部から眼窩下縁にかけて、左側の骨披裂は第二乳臼歯相当部から眼窩下縁にかけて存在した。口蓋裂を伴う両側性斜顔面裂、右側No.4 cleft、左側No.5 cleftと診断し、No.4 cleftには連続Z形成術を応用し、No.5 cleftには口角形成術(松矢法)とZ形成術を応用した形成術を行った。術後経過は良好で、白唇、口角、頬部の良好な形態を確認した。

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Language：Japanese   Publisher：大阪大学歯学会  

11歳男。学校検診で齲蝕を指摘され、某歯科医院を受診したところパラノラマX線検査で両側下顎第二乳臼歯根尖部にX線透過像を認められ当科に紹介された。諸検査により後続永久歯が先天的に欠損した乳臼歯歯根嚢胞と診断した。局所麻酔下に抜歯+嚢胞摘出術を施行し、術後経過良好であった。当院で1985〜2005年に経験した乳歯歯根嚢胞14例について臨床的検討を行った。男女比は1.8:1、初診時年齢は6〜13歳(平均9.6歳)であった。診断契機は「パノラマX線で偶然発見」が最も多く8例(57.1%)、次いで「顎骨の腫脹」4例(28.6%)、「疼痛」2例(14.3%)の順であった。治療法は抜歯+嚢胞摘出が9例(64.3%)、抜歯+開窓術が5例(35.7%)であった。

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Bisphosphonates (BPs) are widely used for the management of hypercalcemia related to malignancy and bone metastases from breast cancer in Japan. We report a case of osteonecrosis of the jaw (ONJ) associated with a history of BPs therapy forthe management of bone metastases from breast cancer. A 69-year-old woman was referred to our department becaused of unhealed extraction sockets of the lower left premolar and first molar, which were removed at a dental clinic. CT scans of the mandible showed regions of mottled bone and sequestra, and a clinical diagnosis of ONJ was made. After conservative treatment with antibiotics and local minor curettage, the inflammatory symptoms almost completely disappeared. Dentists should be aware of this potentially serious complication in patients receiving long-term treatment with BPs.

DOI： 10.5794/jjoms.53.28

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：BLACKWELL PUBLISHING  

Sialolipoma is a new variant of salivary gland lipoma, which was first proposed by Nagao et al. (Histopathology 2001; 38: 30) in 2001. We report this rare case of sialolipoma in the hard palate. A 60-year-old Japanese woman was referred to our department complaining of a painless swelling on the right side of the hard palate. Intra-oral examination revealed a soft, elastic, dome-shaped mass with I cm in diameter located in the posterior part of the hard palate. Magnetic resonance imaging examination revealed high intensity on T-1-weighted image and iso-intensity on T-2-weighted image. Incisional biopsy revealed that the tumor was encapsulated by fibrous tissue, consisted of adipose tissue, and also contained normal salivary gland tissue peripherally. First diagnosed as an ordinary lipoma of the hard palate, the tumor was excised. According to the recent criteria of histologic findings of sialolipoma, we rediagnosed the tumor as sialolipoma of the hard palate.

DOI： 10.1111/j.1600-0714.2006.00409.x

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BACKGROUND: The frequent insertion of self-tapping screws for securing the proximal positioning plate in bimaxillary osteotomy often cause loosening of screws and plate, which produces incorrect repositioning. In this article, a newly developed base-attachment for a T-shaped proximal positioning plate for bimaxillary osteotomy is presented. MATERIAL: The base-attachment set consists of a titanium base-attachment and two titanium tapped screws. The attachment has a shallow depression having the same shape as the basal part of the positioning plate. METHOD: The base-attachment is secured by self-tapping screws until the end of the procedure, and the T-shaped proximal positioning plate is placed and secured by two titanium-tapped screws. RESULT: By using this base-attachment, the T-shaped plate can be easily placed repeatedly without difficulty. CONCLUSION: This base-attachment set may be useful for the frequently repositioned proximal plate in bimaxillary osteotomy.

DOI： 10.1016/j.jcms.2006.01.002

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Chickenpox is a common infection due to varicella-zoster virus (VZV), which generally occurs in childhood. However, the incidence of chickenpox in adults is increasing because of changes in the social environment. In this paper, we report a case of adult chickenpox with the first symptom in the oral cavity. A 32-year-old Japanese woman presented with palatal ulcerative lesions and many bullae on her skin. The first symptom was continuous spontaneous pain at the left upper molar, present for 15 days before her first visit. Intravenous and oral acyclovir was given for a clinical diagnosis of VZV infection. Although the serum antibody examination showed no evidence of VZV infection, the symptoms led to a diagnose of adult chickenpox.

DOI： 10.5794/jjoms.51.505

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCIENCE BV  

Vascularized bone grafts have become the preferred method of mandibular reconstruction. However, the technique is considered to increase both the operating time and blood loss, which might be associated with an increased morbidity and mortality. We conducted a retrospective analysis of 100 consecutive patients who underwent immediate bridging plate reconstruction. The median follow-up duration was 70 months. The 5-year overall survival rate was 69.9%. Cox multivariate analysis revealed that red blood cell transfusion was an independent prognostic factor for the overall survival. The plate survival with no complications was 62.2% at 5 years. Anterolateral defects and preoperative radiotherapy emerged as an independent adverse factor for plate survival. The use of bridging plates is an option for lateral mandibular reconstruction with no preoperative irradiation to avoid the risk from blood transfusion. (C) 2005 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.oraloncology.2005.03.006

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DOI： 10.1016/j.joms.2005.01.011

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DOI： 10.1111/j.1600-0714.2005.00304.x

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Ameloblastoma is one of the well-known odontogenic tumours that can be associated with calcifying odontogenic cysts (COCs), but only a few reports include detailed clinical and radiographic features. In this paper we demonstrate a case of large ameloblastomatous COC in the mandible. The radiographic examination revealed the presence of a multilocular cystic lesion in the right posterior part of the mandible containing the impacted lower second molar with remarkable expansion toward both lingual and buccal side. This feature was different from the general findings of COC and rather resembled that of ameloblastomas.

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Open vertical osteotomy in the mandibular ramus is the one surgical option for the correction of mandible deformity. It is easy to assume that this procedure is useful for open reduction of condylar fractures. In this paper we describe a new systematic procedure for open reduction of high condylar fractures. The procedure involves vertical subcondylotomy and a new retractor for subcondylotomy to protect the mandibular neurovascular bundle.<BR>The major points of this operation are the use of vertical condylotomy, removal of the posterior border of the ramus and plating the condylar head with it, and accurate replacement of the posterior border of the ramus with mini plates prepared before osteotomy.

DOI： 10.5794/jjoms.44.412

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Other Link： http://search.jamas.or.jp/link/ui/1998198548

Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

In this study, we clinically observed 146 patients with sports-related oral and maxillofacial fractures treated at the First Department of Oral and Maxillofacial Surgery, Osaka University Faculty of Dentistry during the past 15 years. The results were as follows.<BR>Among 146 patients, 134 were male and 12 were female. Although 62.5% of the patients were 15 to 24 years of age, there was an annual trend toward a decrease in patients aged 15 to 19 years. The most common causative sport event was baseball (54 patients), followed by rugby football (26 patients) and soccer (15 patients). There was also a decrease in baseballrelated cases and an increase in soccer-related cases in recent years. Isolated mandibular fractures occurred in 92 patients, and the most common site was the mandibular angle, followed by the condyle and canine. Among 37 isolated midface fractures, the most common site was the zygomatic arch (14 patients).<BR>Baseball-related mandibular fractures had a high incidence of two-line fractures and fractures of the anterior portion of the mandibular body as compared with other events.

DOI： 10.5794/jjoms.44.805

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Other Link： http://search.jamas.or.jp/link/ui/1999069467

Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

We report six cases of unilateral transverse facial cleft. Five patients were male and one was female. One case was diagnosed as solitary macrostomia, and other cases had accessory ears. Among latter cases, one also suffered from microtia and was diagnosed as the first and second branchial syndrome. Another case was diagnosed as Goldenhar syndrome because of the presence of epibulbar dermoid. The other cases were diagnosed as the first branchial syndrome.

DOI： 10.5794/jjoms.43.373

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Other Link： http://search.jamas.or.jp/link/ui/1997193080

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DOI： 10.11277/stomatology1952.46.393

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Language：Japanese   Publisher：Japanese Stomatological Society  

Sialolith usually occurs in the submandibular gland and its occurrence in the parotid gland is relatively rare. Especially the occurrence of sialoliths in the bilateral parotid gland is very rare and only three cases of such a case have been reported. In this paper, a case of sialolithiasis occurring in the bilateral parotid gland was reported.<BR>The patient, a 65-year-old Japanese male, visited our clinic complaining of swelling of the right buccal mucosa including the orifice of the parotid duct. Roentogen examination revealed the presense of sialoliths in the right parotid duct and the deep lobe of the left parotid gland. Extirpation of the sialoliths of the right parotid duct was performed under local anesthesia, and 6 sialoliths of 2 mm or less in diameter were observed. Though extirpation of the left sialolith was not performed because of lack of objective and subjective symptoms, long-term follow up is considered nessesary.

DOI： 10.11277/stomatology1952.46.187

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Eight patients with unilateral condylar fractures of the mandible who were treated at our clinic by Martin-Eckelt lag screw osteosynthesis are described.<BR>The patients were aged 14 to 78 years. There were 4 males and 4 females. Four patients had fractures of the base of the condylar process, and four had fractures of the condylar neck. Two patients had no dislocation, four had dislocation, and two had luxation. Clinical examinations 6 months after primary operation showed that mouth opening was not less than 40mm in any patient. Radiographic examinations revealed a correct position and normal form of the condylar head in six patients, but resorption of the condylar head was found in two patients. These two patients required extirpation of condylar head for reduction. Since the use of a lag screw decreases the supply of nutrients from the bone marrow of mandibular ramus to the condylar head, the condylar head should not be removed from the surrounding soft tissue during operation.

DOI： 10.5794/jjoms.43.927

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Other Link： http://search.jamas.or.jp/link/ui/1998090003

Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

Pharyngeal flap surgery is used in the prevention of hypernasality and the devel-opment of articulation disorders that are associated with velopharyngeal incompetence after primary palatal closure. However, surgery may result in failure when the level of the pharyngeal flap base is not determined properly with relation to that of velopharyngeal move-ment or when the flap shrinks because of scar contraction through prolonged exposure of its raw surface. This report describes one patient who had suffered from recurrence of velopharyngeal incompetence after pharyngeal flap surgery. Lateral cephalographic and nasopharyngeal fiberscopic examinations identified the cause of flap atrophy to be marked scar contraction, and the flap base was remarkably lower than the level of velopharyngeal closure in the patient. Unified velopharyngoplasty was newly performed on the basis of find-ings obtained from lateral cephalographic and nasopharyngeal fiberscopic examinations to correct the recurrence of velopharyngeal incompetence in the patient. One year postoperatively, complete closure of the velopharynx in coordination of the flap during speech was confirmed by nasopharyngeal fiberscopy.

DOI： 10.5794/jjoms.42.320

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Other Link： http://search.jamas.or.jp/link/ui/1996193738

Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

We reported two cases of calcifying epithelioma arising in subcutaneous tissue around the auricle. One case was in a 11-year-old Japanese girl who visited our clinic complaining of a mass at the left preauricular region, which had been present since the age of 3. Radiographic examination revealed the presence of calcification measuring 10×8 mm in diameter. Enucleation was performed, and a histopathological diagnosis of a calcifying epithelioma was made. Histopathologically, the tumor was composed mainly of shadow cells, and bone formation was also observed. The other case was in a 52-year old Japanese man, who visited our clinic complaining of a mass at the left side of the neck. The tumor was located at the subauricular region, and the surface of the tumor had undergone partial necrosis. The tumor was enucleated with the surrounding granulation tissue. The histopathological diagnosis was a calcifying epithelioma. Histopathological examination revealed the tumor to be composed of basophilic cells and shadow cells; calcifications were also observed.<BR>The postoperative course of both patients was uneventful, with no evidence of recurrence.

DOI： 10.5794/jjoms.42.693

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Other Link： http://search.jamas.or.jp/link/ui/1997075903

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DOI： 10.11224/cleftpalate1976.21.3_150

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Hemifacial microsomia is defined as a condition affecting primarily aural, oral, and mandibular development and its clinical features may vary. In this paper we report a case of hemifacial microsomia with cleft palate. A Japanese girl 8 months of age was referred to our clinic for the treatment of cleft palate. Clinically, she had hypoplasia and inferior displacement of the left auricle, stenosis of the external auditory canal, a hypoplastic mandible, and facial palsy at the left side of the lower lip. There was no significant asymmetry of the maxillary dental arch or soft palate, and the left side of the soft palate showed mild hypokinesia. Palatoplasty with a push-back method was performed under general anesthesis at the age of 1 year 5 months. A few reports have shown a trend toward velopharyngeal insufficiency in hemifacial microsomia due to hypoplastic palatal muscles and poor neural control of these muscles. In the future, comprehensive speech therapy will be required in this patient.

DOI： 10.5794/jjoms.42.457

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Other Link： http://search.jamas.or.jp/link/ui/1996234675

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DOI： 10.11277/stomatology1952.45.67

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Language：Japanese   Publisher：医歯薬出版(株)  

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We clinically observed patients with sialolithiasis of the submandibular gland who visited our department during the past 10 years (January 1984 to December 1993). The following results were obtained.<BR>One hundred forty-six cases of sialolithiasis of the submandibular gland were diagnosed. The highest proportion of patients were in their 3rd decade of life, and the ratio of men to women was 1 to 1.4. The most common site of occurrence was within the submandibular duct (84.2%), and larger sialoliths tended to occur in the gland and the transitional portion. The main clinical symptoms of submandibular sialolithiasis were swelling and/or tenderness of the gland, and these symptoms tended to occur on the gland side. Infection of the oral cavity tended to occur on the orifice side.

DOI： 10.5794/jjoms.41.890

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Other Link： http://search.jamas.or.jp/link/ui/1996136698

Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

Sialolithiasis mainly occurs in the submandiblar gland and its occurrence in minor salivary glands is very rare. In this paper we report three cases of sialolithiasis occurring in the minor salivary glands of the lip. Two cases occurred in the upper lip and one in the lower lip. Histopathologically, the case in the lower lip consisted of more than six calcified masses in the minor salivary gland tissue.

DOI： 10.5794/jjoms.41.263

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Other Link： http://search.jamas.or.jp/link/ui/1995233309

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Benign fibrous histocytoma is a well-established soft tissue neoplasm, and the occurrence of this lesion in the oral cavity is rare. Only 3 cases of this lesion arising centrally in the mandible have been reported in the literature. In this paper, we reported a patient with benign fibrous histiocytoma of the mandible.<BR>A 42-year-old Japanese woman was referred to our department complaining of swelling on the lingual side of the right mandibular body in November 1987. Radiographic examination demonstrated a illdefined radiolucent lesion in the right body of the mandible extending from 7 to the ramus. We performed segmental resection of the mandible in March 1988. A solid yellowish lesion was observed in the mandible body, and partial destruction of the lingual palate was found. Histopathologically, the lesion was composed of spindle-shaped figroblastic cells and histiocytic cells. The histiocytic cells showed negative staining for S-100 protein and positive staining for a-1 antitrypsin. Based on these clinical and histopathological findings, the lesion was diagnosed as benign fibrous histiocytoma. The postoperative course was good and no signs of recurrence have been seen almost 6 years and 4 months after operation.

DOI： 10.5794/jjoms.40.209

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Other Link： http://search.jamas.or.jp/link/ui/1994186632

Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

This study investigated the correlation between clinical and histopathological findings in 171 cases clinically diagnosed as oral leukoplakia. Histopathological examination revealed squamous cell carcinoma in 14 cases, leukoplakia with epithelial dysplasia in 68 cases, and hyperkeratosis without epithelial dysplasia in 89 cases. According to the grade of epithelial dysplasia, the leukoplakias were classified into mild, moderate, severe epithelial dysplasia and carcinoma in situ, which included 49, 14, 3 and 2 cases, respectively. High grades of epithelial dysplasia were mainly observed on the lateral edge of the tongue or the oral floor. There was a close correlation between the clinical appearance of lesions and a high grade of dysplasia; the majority of the cases with high grades of dysplasia or with early invasive carcinoma clinically showed erosive-type lesions.

DOI： 10.5794/jjoms.40.1290

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Other Link： http://search.jamas.or.jp/link/ui/1995189697

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DOI： 10.5794/jjoms.38.1919

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Other Link： http://search.jamas.or.jp/link/ui/1993238121

Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

Four cases of pituitary hormone deficiency with cleft defects of the lip and palate were reported. In all cases, we noticed the small premaxilla, but there was no cerebral anomaly such as holoprosencephaly.The present report suggests the small premaxilla is a sign of the pituitary hormone deficiency in cleft lip and palate children.This clinical feature would be useful for diagnosis of the pituitary hormone deficiency.

DOI： 10.5794/jjoms.38.818

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Conservative treatment for ameloblastoma frequently produces recurrence. But even after radical treatment for this lesion, recurrence may occur. Recurrence in such cases is most likely due to involvement of adjacent soft tissue structures by tumor tissue.<BR>In such cases of recurrence after conservative treatment, ameloblastoma proliferate immediately in soft tissue and gingiva. We performed segmental resection of mandible bone involving adjacent soft tissue and one-stage microsurgical reconstruction using radial forearm skin flap.

DOI： 10.5794/jjoms.37.398

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DOI： 10.11224/cleftpalate1976.16.4_190

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As cleidocranial dysplasia is one of the systemic bone disorders characterised by anomalies of clavicle, cranium, maxilla and mandible, complications are rarely found in other than the bone system.<BR>We have examined a boy, 8 years and 3 months old when first seen, of this disease accompanied with pseudohypoparathyroidism I, who is perhaps the second reported case in Japan. He was diagnosed to be pseudohypoparathyroidism I based on the attacks of tetany, calcified bodies in the brain found by CT, low Ca and high P levels in the blood, and on the Ellsworth-Howard examination. He was diagnosed to have cleidocranial dysplasia because of the specific motion of approaching shoulders, late existence of the anterior fontanell, and teeth anomalies as written below.<BR>At the examination of 9 years and 4 months, D+D/D+D and cuspids of E/E/E/E erupted, but no permanent tooth had erupted, all remaining in the jaws ascertained by roentgenography. Several serious carious deciduous teeth were extracted at this time. At the examination of 12 years and 3 months, however, no permanent tooth was seen except for the incisor edges of the lower central incisors.<BR>Cephalometric x-ray analysis at 9 years and 4 months revealed maxillary maldevelopment to anterior and down directions, progenia, and maldevelopment of the mandibular angle. These were also found at the 12 years 3 months examination, but the amount of the maxillary and mandibular developments during these periods were nearly the same as that of normal boys.<BR>The etiology of cleidocrnial dysplasia was discussed based on the present case and on some literatures reporting the complications that accompanied this disease.

DOI： 10.5794/jjoms.35.755

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This study was intended to clarify the mechanical contraction properties of the tensor veli palatini muscle in dogs. Twenty adult dogs were used under an intraperitoneum anesthesia of the pentobarbital sodium. The tension of the tensor veli paltini muscle was recorded by electrical stimulation to the motor nerve.<BR>Results were as follows:<BR>1. The contraction time and half relaxation time of maximal isometric twitch of the muscle were calculated as 13.7±0.7 msec and 10.4±1.2 msec, respectively.<BR>2. A clear summation of muscle contractions was obtained with stimulation at 20 Hz and maximal tetanic tension was at 90 Hz. The tetanus twitch tension ratio wasfound to be 10.7±1.1.<BR>3. The maximum rate of tension rise was observed at 150 Hz and value was 2.5±0.5 times as long as the rate of a twitch contraction.<BR>4. The contraction rate of an isotonic twitch was 3.2±0.7% and the maximum contraction rate was obtained at 80 Hz which was 26.3±1.9%.

DOI： 10.5794/jjoms.34.1845

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Language：Japanese   Publisher：(NPO)日本顎変形症学会  

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Language：Japanese   Publisher：日本法歯科医学会  

J-GLOBAL

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J-GLOBAL

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Language：Japanese   Publisher：日本画像医学会  

J-GLOBAL

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Language：Japanese   Publisher：岡山歯学会  

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Language：Japanese   Publisher：(公社)日本矯正歯科学会  

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Language：English   Publishing type：Book review, literature introduction, etc.  

Mesenchymal stem cells (MSCs) have emerged as a promising alternative to traditional surgical techniques. The purpose of this review is to document the current state of research and identify future research directions. At present, no specific markers have been shown to specifically identify MSCs. The most commonly reported positive markers are CD105, CD90, CD44, CD73, CD29, CD13, CD34, CD146, CD106, CD54 and CD166. The most frequently reported negative markers are CD34, CD14, CD45, CD11b, CD49d, CD106, CD10 and CD31. Regarding the source of MSCs, bone marrow-derived MSCs are the most frequently studied MSCs in bone regeneration
however, no reports have demonstrated advantages of bone marrow-derived MSCs over other types of MSCs in bone regeneration. For the purpose of clinical use, serum-free media is recommended to avoid risks connected with the use of animal products. Attempts have been made to develop defined serum-free media for animal and human MSC growth
however, most products have demonstrated only limited performance. Tumorigenesis is the other major problem in MSC regeneration. It is strongly recommended to prepare MSCs for tissue regeneration at early passages to avoid potential chromosomal abnormalities. © 2012 Japanese Association for Dental Science.

DOI： 10.1016/j.jdsr.2012.11.003

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Language：Japanese   Publishing type：Research paper, summary (national, other academic conference)   Publisher：(NPO)日本口腔科学会  

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Language：Japanese   Publishing type：Research paper, summary (national, other academic conference)   Publisher：(NPO)日本口腔科学会  

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Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

DOI： 10.5794/jjoms.58.501

CiNii Article

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Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

Maxillary anterior segmental distraction osteogenesis (MASDO) is a rather new surgical orthodontic treatment to produce an ideal maxillary dental arch form in patients with cleft lip and palate. Different from total maxillary advancement by DO, this surgical procedure can solves the problems in the small and retruded maxilla without the risk of deterioration of velopharyngeal function, because the distracted segment is only made at the anterior part of the maxillary bone.<br>To advance the anterior segment in only a single vector, a single palatal bone-borne distractor or toothborne distractor is effective, but two hybrid type distractors on each side of alveolar process can produce some rotational movements of anterior segment by controlling advancement amount in each side. Therefore, this procedure solves not only the size of maxillary arch but also the shape of deformed dental arch.<br>As bone height and width at distracted space on alveolar process is enough for fuature alignments of crowding teeth or anterior movement of molars, this treatment is an effective pre-orthodontic surgical treatment for solving discrepancy of maxillary dental arch.

DOI： 10.5794/jjoms.58.562

CiNii Article

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Language：Japanese   Publisher：(公社)日本口腔外科学会  

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Language：Japanese   Publisher：(公社)日本口腔外科学会  

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Language：Japanese   Publisher：岡山歯学会  

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Language：Japanese   Publisher：(NPO)日本口腔科学会  

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Language：Japanese   Publisher：(NPO)日本口腔科学会  

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Language：Japanese   Publisher：(NPO)日本口腔科学会  

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Language：Japanese   Publishing type：Research paper, summary (national, other academic conference)   Publisher：(公社)日本口腔外科学会  

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Language：Japanese   Publisher：(公社)日本口腔外科学会  

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Language：Japanese   Publisher：(公社)日本口腔外科学会  

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Language：Japanese   Publisher：(一社)日本口蓋裂学会  

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Language：Japanese   Publisher：(NPO)日本口腔科学会  

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Language：Japanese   Publisher：(一社)日本口蓋裂学会  

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Language：Japanese   Publisher：(NPO)日本口腔科学会  

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Language：Japanese   Publisher：(公社)日本口腔外科学会  

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DOI： 10.5843/jsot.19.7

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Language：Japanese   Publisher：(公社)日本口腔外科学会  

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Event date： 2020

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Event date： 2019.7

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Event date： 2019.5.25

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Event date： 2018.6.30

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Event date： 2017

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インプラント体の上顎洞内への迷入症例6例について、カルテ記載事項と画像等の検査結果を後ろ向きに調査した。その結果、迷入判明から当科初診までの期間は当日〜約1ヵ月後であった。初診時年齢は平均57.3歳で、埋入部位は不明の1例を除き上顎第一大臼歯部であった。迷入時期はインプラント埋入時が2例、埋入1週間後に経過不良のためインプラント摘出を試みた際に迷入させた症例が1例、埋入後の経過観察中が1例、上部構造装着後が1例、不詳が1例であった。自覚症状を認めた症例は3例で、いずれも鼻閉等の鼻症状であり、うち1例には嗅覚障害を認めた。インプラント体は全例で結果的に体外に出ており、4例に摘出術を施行し、うち2例が歯槽部からの摘出、1例が犬歯窩(上顎洞開放術)からの摘出、1例が鼻内内視鏡手術であった。残り2例は、消炎および経過観察中に自然排出していた。迷入部位は上顎洞下方4例、上顎洞中央1例、自然孔1例であった。

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Event date： 2016.12.15

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Event date： 2016.12

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Event date： 2016.12

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Other Link： http://search.jamas.or.jp/link/ui/2017215458

Event date： 2016.7

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Event date： 2016

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Event date： 2016

We report a case of calcifying cystic odontogenic tumor (CCOT) with odontoma developing in the deciduous dentition period, and present previously reported cases in Japan. A 5-year-old boy visited a dental clinic because of swelling on his left mandibular buccal alveolar region, and was referred to our department. Clinical examination revealed a 20-mm (in diameter), bone-like, hard mass on the left mandibular buccal gingiva at the first deciduous molar region. A panoramic radiograph showed a 25 mm × 20 mm, unilocular, cystic radiolucent area from the left mandibular second deciduous molar to the first molar region. There were radiopaque tiny flecks at the upper side of the lesion. The clinical diagnosis was a benign tumor of the left mandible. Consequently, tumor enucleation was performed under general anesthesia. Histopathological diagnosis confirmed a CCOT associated with odontoma. Five years after surgery, the left mandibular region has healed well, with no evidence of recurrence.

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Event date： 2016

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Event date： 2016

Language：English  

A palatal augmentation prosthesis (PAP) is used to facilitate improvement in the speech and swallowing functions of patients with tongue resection or tongue movement disorders. However, a PAP's effect is limited in cases where articulation disorder is severe due to wide glossectomy and/or segmental mandibulectomy. In this paper, we describe speech outcomes of a patient with an articulation disorder following glossectomy and segmental mandibulectomy. We used a palatal plate (PP) based on a PAP, along with an artificial tongue (KAT). Speech improvement was evaluated by a standardized speech intelligibility test consisting of 100 syllables. The speech intelligibility score was significantly higher when the patient wore both the PP and KAT than when he wore neither (p＝0.013). The conversational intelligibility score was significantly improved with the PP and KAT than without PP and KAT (p＝0.024). These results suggest that speech function can be improved in patients with hard tissue defects with segmental mandibulectomy using both a PP and a KAT. The nature of the design of the PP and that of the KAT will allow these prostheses to address a wide range of tissue defects.

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Event date： 2016

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Event date： 2016

Language：English  

We report a case involving a young female patient with severe mandibular retrognathism accompanied by mandibular condylar deformity that was effectively treated with Le Fort I osteotomy and two genioplasty procedures. At 9 years and 9 months of age, she was diagnosed with Angle Class III malocclusion, a skeletal Class II jaw relationship, an anterior crossbite, congenital absence of some teeth, and a left-sided cleft lip and palate. Although the anterior crossbite and narrow maxillary arch were corrected by interceptive orthodontic treatment, severe mandibular hypogrowth resulted in unexpectedly severe mandibular retrognathism after growth completion. Moreover, bilateral condylar deformities were observed, and we suspected progressive condylar resorption (PCR). There was a high risk of further condylar resorption with mandibular advancement surgery;. therefore, Le Fort I osteotomy with two genioplasty procedures was performed to achieve counterclockwise rotation of the mandible and avoid ingravescence of the condylar deformities. The total duration of active treatment was 42 months. The maxilla was impacted by 7.0 mm and 5.0 mm in the incisor and molar regions, respectively, while the pogonion was advanced by 18.0 mm. This significantly resolved both skeletal disharmony and malocclusion. Furthermore, the hyoid bone was advanced, the pharyngeal airway space was increased, and the morphology of the mandibular condyle was maintained. At the 30-month follow-up examination, the patient exhibited a satisfactory facial profile. The findings from our case suggest that severe mandibular retrognathism with condylar deformities can be effectively treated without surgical mandibular advancement, thus decreasing the risk of PCR.

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Other Link： http://synapse.koreamed.org/DOIx.php?id=10.4041/kjod.2016.46.6.395

Event date： 2016

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Event date： 2013.4.20

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Substantial progress has been made in the development of cell therapy; however, there have been no practical applications related to bone regeneration. We analyzed mouse bone-marrow-derived lineage (-) cells and compact bone-derived lineage (-) cells as candidate mesenchymal stem cells (MSCs), and confirmed bone regeneration &lt;i&gt;in vivo&lt;/i&gt;. Materials and Methods: Bone marrow-derived cells were collected from the femurs of 5-week-old C57-GFP male mice. Bone marrow-derived cells were harvested by removing the epiphyses and flushing with medium, after which the femurs were broken into approximately 1 mm&lt;sup&gt;3&lt;/sup&gt; fragments and treated with collagenase II. Cells released from the compact bone were aspirated and cultured with the bone fragments. These cells were cultured in alpha-MEM supplemented with 20% fetal bovine serum at 37℃ in a 5% CO&lt;sub&gt;2&lt;/sub&gt; humidified incubator for 3 days, and the difference between bone marrow-derived cells and compact bonederived cells was investigated. After 3 days of incubation, cells were labeled with allophycocyanin (APC) antilineage antibody cocktail, analyzed by flow cytometry, and sorted into lineage (+) or lineage (-) populations. Cells that had acquired lineage (-) were then induced to differentiate into osteogenic lineages by incubation with osteogenic media for 3 days. Differentiated cells and 50 mg of beta-TCP were mixed to form an osteogenic pellet. Pellet samples were implanted into subcutaneous pouches of SCID mice and retrieved after 4 weeks. Tissue samples were fixed in 1.5% paraformaldehyde and embedded in paraffin. Sections were stained with hematoxylin and eosin, and immunohistochemical analysis were performed using anti-GFP antibody. Results: Approximately 90% of bone marrow-derived cells expressed lineage markers. However, only 40% of compact bone-derived cells expressed these markers. Both bone marrow-derived and compact bone-derived cells sorted as lineage (-) showed fibroblastic shapes and plastic-adhesion ability. The number of lineage (-) cells from an individual mouse femur was about 10,000 from bone marrow and about 400,000 from compact bone. Moreover, we found that cells isolated from compact bone and sorted as lineage (-) cells were capable of supporting bone formation &lt;i&gt;in vivo&lt;/i&gt;. The methods and results described here may facilitate understanding of MSC biology and lead to clinical applications.

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Event date： 2013.4.20

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Event date： 2011.9

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