研究者詳細 - 山岡　聖典

論文 - 山岡　聖典

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放射線ホルミシスの研究動向について招待査読

山岡聖典

放連通信 33 ( 1 ) 13 - 22 1995年6月

Changes in specific amino acid residues and Na+,K+-ATPase activity in cell membranes of rat cerebral cortex by low dose X-irradiation 査読

K.Yamaoka, K.Ishii, R.Edamatsu, T.Ito, A.Mori

Physiological Chemistry & Physics and Medical NMR 26 ( 4 ) 323 - 328 1994年8月

老齢ラットに及ぼす低線量X線照射の老化抑制効果の検討査読

山岡聖典, 枝松礼, 森昭胤

電力中央研究所研究報告 16 ( 4 ) 529 - 534 1994年8月

Induction of two species of superoxide dismutase in some organs of rats by low dose X-irradiation 査読

K.Yamaoka, E.F.Sato, K.Utsumi

Physiological Chemistry & Physicsand Medical NMR 26 ( 3 ) 205 - 214 1994年6月

Study on effects of low dose radiation on biological function:1)Increased SOD activities and decreased lipid peroxides levels induced by low dose X irradiation in rat organs, 2)Effects of low dose X-ray irradiation on biomembrane in brain cortex of aged rats, and 3)Effects of radon inhalation on biological function -Lipid peroxide, superoxide dismutase activity and membrane fluidity 査読

Kiyonori Yamaoka

岡山大学医学博士論文（生理学専攻）Okayama University Doctoral Thesis of Medicine 1994年3月

Effects of low dose X-irradiation on biomembrane in brain cortex of aged rats 査読

K.Yamaoka, R.Edamatsu, T.Ito, A.Mori

Free Radical Biology & Medicine 16 ( 4 ) 529 - 534 1994年

ラドン泉吸入の生体機能に及ぼす影響ー家兎における過酸化脂質量とSOD活性― 査読

山岡聖典, 古元嘉昭, 鈴鹿伊智雄, 枝松礼, 森昭胤

過酸化脂質研究 17 ( 3 ) 271 - 273 1993年10月

低線量放射線が過酸化脂質量，SOD活性，および膜流動性に及ぼす影響ーラドン温泉の適応症および老化抑制との関連に着目してー査読

山岡聖典, 枝松礼, 古元嘉昭, 鈴鹿伊智雄, 森昭胤

磁気共鳴と医学 4 82 - 89 1993年5月

Effects of radon inhalation on biological function -Lipid peroxide, SOD activity and membrane fluidity- 査読

K.Yamaoka, Y.Komoto, I.Suzuka, R.Edamatsu, A.Mori

Archives of Biochemistry and Biophysics 302 ( 1 ) 37 - 41 1993年4月

Increased SOD activities and decreased lipid peroxides levels in rat organs induced by low dose X-irradiation 査読

K.Yamaoka, R.Edamatsu, A.Mori

Free Radical Biology & Medicine 11 ( 3 ) 299 - 306 1991年6月

放射線ホルミシス査読

服部禎男, 根本和泰, 石田健二, 御園生淳, 菅沼浩敏, 石井敬一郎, 山岡聖典

日本原子力学会誌 32 ( 7 ) 688 - 696 1990年7月

Effect of radon inhalation on murine brain proteins: Investigation using proteomic and multivariate analyses 査読

Shota Naoe, Ayumi Tanaka, Norie Kanzaki, Reiju Takenaka, Akihiro Sakoda, Takaaki Miyaji, Kiyonori Yamaoka, Takahiro Kataoka

Acta Medica Okayama 78 ( 5 ) 387 - 399 2024年10月

総説ラドン・トロンの健康効果に関する最近の研究動向 Ⅱ 招待査読

山岡聖典

日本機能性イオン協会誌 33 ( 1 ) 3 - 11 2024年1月

Effects of low-dose/high-dose-rate X-irradiation on oxidative stress in organs following forced swim test and its combined effects on alcohol-induced liver damage in mice 査読

Shota Naoe, Yuki Fujimoto, Kaito Murakami, Ryohei Yukimine, Ayumi Tanaka, Kiyonori Yamaoka, Takahiro Kataoka

Journal of Radiation Research 64 ( 4 ) 635 - 643 2023年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford University Press (OUP)

Abstract

The liver’s susceptibility to oxidative stress after a combination of forced swim test (FST) and low-dose-rate γ-irradiation has been observed. Therefore, this study aims to clarify the effects of low-dose (0.1 and 0.5 Gy)/high-dose-rate (1.2 Gy/min) irradiation on combined oxidative stressors—liver damage associated with FST and alcohol administration. In addition, the effects of similar irradiation on FST-induced immobility, which induces psychomotor retardation, and antioxidative effects on the brain, lungs, liver and kidneys were investigated, and the results were compared with those of a similar previous study that utilized low-dose-rate irradiation. Low-dose/high-dose-rate (especially 0.5 Gy) irradiation temporarily worsened liver antioxidant function and hepatic function with FST- and alcohol administration-related oxidative damage; however, the damages improved soon after. In addition, the increase in total glutathione content in the liver contributed to the early improvement of hepatic functions. However, pre-irradiation did not suppress immobility during the FST. The results also suggested that the effects of low-dose/high-dose-rate irradiation on the antioxidant functions of each organ after the FST were different from those of low-dose/low-dose-rate irradiation. Overall, this study provides further insights into the effects of low-dose irradiation on exposure to a combination of different oxidative stressors. It will also contribute to the elucidation of dose rate effects on oxidative stress in the low-dose irradiation range.

DOI： 10.1093/jrr/rrad030

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Changes in sulfur metabolism in mouse brains following radon inhalation 査読

Norie Kanzaki, Akihiro Sakoda, Takahiro Kataoka, Lue Sun, Hiroshi Tanaka, Iwao Ohtsu, Kiyonori Yamaoka

International Journal of Environmental Research and Public Health 19(17), 10750 2022年8月

担当区分：最終著者掲載種別：研究論文（学術雑誌）出版者・発行元：MDPI AG

Therapy using hot springs, including the high-level radioactive gas “radon”, is traditionally conducted as an alternative treatment for various diseases. Oxidative-stress-related diseases are inhibited by the enhancement of antioxidative functions following radon inhalation. We have reported that radon inhalation increased the level of anti-oxidants, such as glutathione (G-SH), in the brain and had a protective antioxidative effect against transient global cerebral ischemic injury. However, no studies have yet revealed the changes in G-SH associated substances after radon inhalation. In this study, we comprehensively analyzed several metabolites, focusing on G-SH. Mice were exposed to radon at concentrations of 200, 2000, or 20,000 Bq/m3 for 1, 3, or 10 days. We detected 27 metabolites in the mouse brains. The result showed that the L-methionine levels increased, whereas the levels of urea, glutathione, and sulfite ion decreased under any condition. Although the ratio of G-SH to oxidized glutathione (GS-SG) decreased, glutathione monosulfide (G-S-SH) and cysteine monosulfide (Cys-S-SH) increased after radon inhalation. G-S-SH and Cys-S-SH can produce a biological defense against the imbalance of the redox state at very low-dose irradiation following radon inhalation because they are strong scavengers of reactive oxygen species. Additionally, we performed an overall assessment of high-dimensional data and showed some specific characteristics. We showed the changes in metabolites after radon inhalation using partial least squares-discriminant analysis and self-organizing maps. The results showed the health effects of radon, especially the state of sulfur-related metabolites in mouse brains under the exposure conditions for radon therapy.

DOI： 10.3390/ijerph191710750

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A simple method for estimating the potential of the pyroelectric crystal surface 査読

Katsumi Hanamoto, Takahiro Kataoka, Kiyonori Yamaoka

Applied Radiation and Isotopes 185 110230 2022年7月

Radon solubility and diffusion in the skin surface layers 査読

Akihiro Sakoda, Tsuyoshi Ishida, Takahahiro Kataoka, Norie Kanzaki, Hiroshi Tanaka, Fumihiro Mitsunobu, Kiyonori Yamaoka

International Journal of Environmental Research and Public Health 19(13), 7761 2022年6月

担当区分：最終著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：MDPI AG

In specific situations such as bathing in a radon spa, where the radon activity concentration in thermal water is far higher than that in air, it has been revealed that radon uptake via skin can occur and should be considered for more precise dose evaluation. The primary aim of the present study was to numerically demonstrate the distribution as well as the degree of diffusion of radon in the skin, with a focus on its surface layer (i.e., stratum corneum). We developed a biokinetic model that included diffusion theory at the stratum corneum, and measured radon solubility in that tissue layer as a crucial parameter. The implementation of the model suggested that the diffusion coefficient in the stratum corneum was as low as general radon-proof sheets. After a 20-min immersion in water, the simulated depth profile of radon in the skin showed that the radon activity concentration at the top surface skin layer was approximately 103 times higher than that at the viable skin layer. The information on the position of radon as a radiation source would contribute to special dose evaluation where specific target cell layers are assumed for the skin.

DOI： 10.3390/ijerph19137761

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Radon inhalation decreases DNA damage induced by oxidative stress in mouse organs via the activation of antioxidative functions 査読国際誌

Takahiro Kataoka, Hina Shuto, Shota Naoe, Junki Yano, Norie Kanzaki, Akihiro Sakoda, Hiroshi Tanaka, Katsumi Hanamoto, Fumihiro Mitsunobu, Hiroaki Terato, Kiyonori Yamaoka

Journal of Radiation Research 62 ( 5 ) 861 - 867 2021年9月

Dosimetry of radon progeny deposited on skin in air and thermal water 査読国際誌

Akihiro Sakoda, Yuu Ishimori, Norie Kanzaki, Hiroshi Tanaka, Takahiro Kataoka, Fumihiro Mitsunobu, Kiyonori Yamaoka

Journal of Radiation Research 62 ( 4 ) 634 - 644 2021年7月

Evaluation of the redox state in mouse organs following radon inhalation 査読国際誌

Takahiro Kataoka, Norie Kanzaki, Akihiro Sakoda, Hina Shuto, Junki Yano, Shota Naoe, Hiroshi Tanaka, Katsumi Hanamoto, Hiroaki Terato, Fumihiro Mitsunobu, Kiyonori Yamaoka

Journal of Radiation Research 62 ( 2 ) 206 - 216 2021年3月

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