研究者詳細 - 山岡　聖典

論文 - 山岡　聖典

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ラドン温泉療法の適応症とそのメカニズムに関する最近の研究動向査読

片岡隆浩,迫田晃弘,神崎訓枝,光延文裕,山岡聖典

日本温泉気候物理医学会雑誌 88 ( 2 ) 57 - 72 2025年5月

トロンの生体作用とラドンとの比較に関する研究査読

山岡聖典, 片岡隆浩

Radioisotopes 74 ( 1 ) 87 - 89 2025年3月

Association between radon hot spring bathing and health conditions: A cross-sectional study in Misasa, Japan 査読

Takahiro Kataoka, Hiroshi Habu, Ayumi Tanaka, Shota Naoe, Kaito Murakami, Yuki Fujimoto, Ryohei Yukimine, Soshi Takao, Fumihiro Mitsunobu, Takashi Yorifuji, Kiyonori Yamaoka

Acta Medica Okayama 77 ( 4 ) 387 - 394 2023年8月

Immunomodulatory effects of radon inhalation on lipopolysaccharide-induced inflammation in mice 査読

Takahiro Kataoka, Shota Naoe, Kaito Murakami, Yuki Fujimoto, Ryohei Yukimine, Ayumi Tanaka, Kiyonori Yamaoka

International Journal of Environmental Research and Public Health 19(17), 10632 2022年8月

担当区分：最終著者,　責任著者掲載種別：研究論文（学術雑誌）出版者・発行元：MDPI AG

Typical indications for radon therapy include autoimmune diseases such as rheumatoid arthritis (RA). We had previously reported that radon inhalation inhibits Th17 immune responses in RA mice by activating Th1 and Th2 immune responses. However, there are no reports on how radon inhalation affects the activated Th1 and Th17 immune responses, and these findings may be useful for identifying new indications for radon therapy. Therefore, in this study, we investigated the effect of radon inhalation on the lipopolysaccharide (LPS)-induced inflammatory response, focusing on the expression of related cytokines and antioxidant function. Male BALB/c mice were exposed to 2000 Bq/m3 radon for one day. Immediately after radon inhalation, LPS was administered intraperitoneally at 1.0 mg/kg body weight for 4 h. LPS administration increased the levels of Th1- and Th17-prone cytokines, such as interleukin-2, tumor necrosis factor-α, and granulocyte-macrophage colony-stimulating factor, compared to no treatment control (sham). However, these effects were suppressed by radon inhalation. IL-10 levels were significantly increased by LPS administration, with or without radon inhalation, compared to sham. However, radon inhalation did not inhibit oxidative stress induced by LPS administration. These findings suggest that radon inhalation has immunomodulatory but not antioxidative functions in LPS-induced injury.

DOI： 10.3390/ijerph191710632

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Potential inhibitory effects of low-dose thoron inhalation and ascorbic acid administration on alcohol-induced hepatopathy in mice 査読

Takahiro Kataoka, Tsuyoshi Ishida, Shota Naoe, Norie Kanzaki, Akihiro Sakoda, Hiroshi Tanaka, Fumihiro Mitsunobu, Kiyonori Yamaoka

Journal of Radiation Research 63 ( 5 ) 719 - 729 2022年7月

担当区分：最終著者,　責任著者掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford University Press (OUP)

Abstract

Although thoron inhalation exerts antioxidative effects in several organs, there are no reports on whether it inhibits oxidative stress-induced damage. In this study, we examined the combined effects of thoron inhalation and ascorbic acid (AA) administration on alcohol-induced liver damage. Mice were subjected to thoron inhalation at 500 or 2000 Bq/m3 and were administered 50% ethanol (alcohol) and 300 mg/kg AA. Results showed that although alcohol administration increased the levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) in the serum, the combination of thoron inhalation (500 Bq/m3) and AA administration 24 h after alcohol administration effectively inhibited alcohol-induced liver damage. The combination of thoron inhalation (500 Bq/m3) and AA administration 24 h after alcohol administration increased catalase (CAT) activity. Alcohol administration significantly decreased glutathione (GSH) levels in the liver. The GSH content in the liver after 2000 Bq/m3 thoron inhalation was lower than that after 500 Bq/m3 thoron inhalation. These findings suggest that the combination of thoron inhalation at 500 Bq/m3 and AA administration has positive effects on the recovery from alcohol-induced liver damage. The results also suggested that thoron inhalation at 500 Bq/m3 was more effective than that at 2000 Bq/m3, possibly because of the decrease in GSH content in the liver. In conclusion, the combination of thoron inhalation at 500 Bq/m3 and AA administration promoted an early recovery from alcohol-induced liver damage.

DOI： 10.1093/jrr/rrac046

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Mechanisms of action of radon therapy on cytokine levels in normal mice and rheumatoid arthritis mouse model 査読

Takahiro Kataoka, Shota Naoe, Kaito Murakami, Ryohei Yukimine, Yuki Fujimoto, Norie Kanzaki, Akihiro Sakoda, Fumihiro Mitsunobu, Kiyonori Yamaoka

Journal of Clinical Biochemistry and Nutrition 70 ( 2 ) 154 - 159 2022年3月

Confirmation of efficacy, elucidation of mechanism, and new search for indications of radon therapy 査読

Kiyonori Yamaoka, Takahiro Kataoka

Journal of Clinical Biochemistry and Nutrition 70 ( 2 ) 87 - 92 2022年3月

The effects of low-dose-rate γ-irradiation on forced swim test-Induced immobility and oxidative stress in mice. 査読

Tetsuya Nakada, Takahiro Kataoka, Takaharu Nomura, Hina Shuto, Junki Yano, Shota Naoe, Katsumi Hanamoto, Kiyonori Yamaoka

Acta Medica Okayama 75 ( 2 ) 169 - 175 2021年4月

X-Irradiation at 0.5 Gy after the forced swim test reduces forced swimming-induced immobility in mice 査読国際誌

Takahiro Kataoka, Hina Shuto, Junki Yano, Shota Naoe, Tsuyoshi Ishida, Tetsuya Nakada, Keiko Yamato, Katsumi Hanamoto, Takaharu Nomura, Kiyonori Yamaoka

Journal of Radiation Research 61 ( 4 ) 517 - 523 2020年

Comparison of antioxidative effects between radon and thoron inhalation in mouse organs. 査読国際誌

Yusuke Kobashi, Takahiro Kataoka, Norie Kanzaki, Tsuyoshi Ishida, Akihiro Sakoda, Hiroshi Tanaka, Yuu Ishimori, Fumihiro Mitsunobu, Kiyonori Yamaoka

Radiation and Environmental Biophysics 59 ( 3 ) 473 - 482 2020年

Comparative effects of radon inhalation according to mouse strain and cisplatin dose in a cisplatin-induced renal damage model 査読

Sasaoka Kaori, Kataoka Takahiro, Kanzaki Norie, Kobashi Yusuke, Sakoda Akihiro, Ishimori Yuu, Yamaoka Kiyonori

Pakistan Journal of Zoology 50 ( 3 ) 1157 - 1170 2018年4月

Radon inhalation induces manganese-superoxide dismutase in mouse brain via nuclear factor-κB activation 査読国際誌

Takahiro Kataoka, Reo Etani, Norie Kanzaki, Yusuke Kobashi, Yuto Yunoki, Tsuyoshi Ishida, Akihiro Sakoda, Yuu Ishimori, Kiyonori Yamaoka

Journal of Radiation Research 58 ( 6 ) 887 - 893 2017年11月

Protective effects of hot spring water drinking and radon inhalation on ethanol-induced gastric mucosal injury in mice 査読国際誌

Reo Etani, Takahiro Kataoka, Norie Kanzaki, Akihiro Sakoda, Hiroshi Tanaka, Yuu Ishimori, Fumihiro Mitsunobu, Takehito Taguchi, Kiyonori Yamaoka

Journal of Radiation Research 58 ( 5 ) 614 - 625 2017年9月

Analysis of liver damage from radon, X-ray, or alcohol treatments in mice using a self-organizing map 査読国際誌

Norie Kanzaki, Takahiro Kataoka, Reo Etani, Kaori Sasaoka, Akihiro Kanagawa, Kiyonori Yamaoka

Journal of Radiation Research 58 ( 1 ) 33 - 40 2017年2月

Evaluating the protective effects of radon inhalation or ascorbic acid treatment after transient global cerebral ischemic injury in gerbils 査読

Takahiro Kataoka, Reo Etani, Norie Kanzaki, Kaori Sasaoka, Yusuke Kobashi, Katsumi Hanamoto, Takehito Taguchi, Kiyonori Yamaoka

Journal of Nuclear Science and Technology 53 ( 11 ) 1681 - 1685 2016年11月

Radon inhalation suppresses nephropathy in streptozotocin-induced type-1 diabetic mice 査読

Yuichi Nishiyama, Takahiro Kataoka, Keiko Yamato, Reo Etani, Takehito Taguchi, Kiyonori Yamaoka

Journal of Nuclear Science and Technology 53 ( 6 ) 909 - 915 2016年6月

Difference in the action mechanism of radon inhalation and radon hot spring water drinking in suppression of hyperuricemia in mice 査読国際誌

Reo Etani, Takahiro Kataoka, Norie Kanzaki, Akihiro Sakoda, Hiroshi Tanaka, Yuu Ishimori, Fumihiro Mitsunobu, Kiyonori Yamaoka

Journal of Radiation Research 57 ( 3 ) 250 - 257 2016年6月

Activation of antioxidative functions by radon inhalation enhances the mitigation effects of pregabalin on chronic constriction injury-induced neuropathic pain in mice 査読国際誌

Takahiro Kataoka, Shunsuke Horie, Reo Etani, Norie Kanzaki, Kaori Sasaoka, Yusuke Kobashi, Katsumi Hanamoto, Kiyonori Yamaoka

Oxidative Medicine and Cellular Longevity Article ID 9853692 1 - 8 2016年

Combined effects of radon inhalation and antioxidant vitamin administration on acute alcohol-induced hepatopathy in mice 査読

Reo Etani, Takahiro Kataoka, Yuichi Nishiyama, Yuji Takata, Kiyonori Yamaoka

Journal of Nuclear Science and Technology 52 ( 12 ) 1512 - 1518 2015年12月

Recent studies on anti-inflammatory effects of radon inhalation in mice 査読

Norie Kanzaki, Takahiro Kataoka, Reo Etani, Kiyonori Yamaoka

Inflammation and Cell Signaling 1 ( 6 ) 1 - 5 2015年5月

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