2024/02/29 更新

写真a

ヤマオカ キヨノリ
山岡 聖典
YAMAOKA Kiyonori
所属
保健学域 教授
職名
教授
連絡先
メールアドレス
外部リンク

学位

  • 理学博士 ( 早稲田大学 )

  • 医学博士 ( 岡山大学 )

研究キーワード

  • 放射線防護学

  • 健康長寿科学

  • 放射線健康科学

  • 酸化ストレス

  • 生体防御機能

  • 生体応答解析学

  • 安全安心科学

研究分野

  • ライフサイエンス / 放射線科学

  • 環境・農学 / 化学物質影響

  • 環境・農学 / 放射線影響

  • エネルギー / 原子力工学  / 放射線安全

  • ライフサイエンス / 薬系衛生、生物化学  / 生体防御、疾病予防

  • ライフサイエンス / 栄養学、健康科学

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経歴

  • 岡山大学学術研究院特任教授・名誉教授

    2021年4月 - 現在

  • 岡山大学学術研究院 特任教授・特命教授

    2021年 - 現在

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  • 岡山大学 名誉教授

    2021年 - 現在

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  • 岡山大学耐災安全安心センター(全学) 教授 部門長,副センター長他併任

    2014年 - 2018年

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  • 金沢大学大学院 教育教員(委嘱)

    2010年 - 現在

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  • 東京工業大学大学院 講義等委託教員

    2010年 - 現在

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  • 岡山大学大学院保健学研究科・医学部 教授 入試委員長,医学部長補佐他

    2007年 - 2021年

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  • 岡山大学医学部 教授,大学院自然科学研究科博士後期課程(薬学系)兼担

    2003年 - 2007年

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  • 岡山大学医学部 助教授,大学院自然科学研究科博士後期課程(薬学系)兼担

    1999年 - 2003年

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  • 東京大学 客員研究員

    1996年 - 1999年

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  • 理化学研究所 研究嘱託

    1987年 - 1989年

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  • 電力中央研究所 労組中執委員長,上席研究員他

    1982年 - 1999年

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  • 明治薬科大学

    1998年 - 1999年

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  • 静岡県立大学大学院 非常勤講師

    1997年 - 1998年

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所属学協会

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委員歴

  • 日本原子力学会 フェロー,理事  

    2020年 - 現在   

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    団体区分:学協会

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  • 日本原子力学会中国・四国支部 顧問  

    2020年 - 現在   

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    団体区分:学協会

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  • 大学改革支援・学位授与機構国立大学教育研究評価委員会 専門委員  

    2020年 - 2021年   

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    団体区分:政府

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  • 日本原子力学会 評議員,大会現地委員会委員長  

    2018年 - 2020年   

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    団体区分:学協会

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  • 日本原子力学会中国・四国支部 副支部長,支部長  

    2016年 - 2020年   

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    団体区分:学協会

    日本原子力学会

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  • 日本ラドン研究推進協会 副理事長  

    2009年 - 2021年   

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    団体区分:学協会

    日本ラドン研究推進協会

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  • 原子力分野における大学連携ネットワーク連携協力推進協議会 委員  

    2008年 - 現在   

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    団体区分:政府

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  • ラドン温泉医療による健康日本推進三朝会議 理事  

    2008年 - 現在   

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    団体区分:学協会

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  • Society for Free Radical Research International 正会員  

    2007年 - 現在   

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    団体区分:学協会

    国際フリーラジカル学会(Society for Free Radical Research)

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  • 岡山大学・日本原子力研究開発機構連携協議会 委員  

    2007年 - 現在   

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  • 日本酸化ストレス学会 評議員・代議員,理事  

    2001年 - 現在   

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    団体区分:学協会

    日本酸化ストレス学会

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  • 中国電力 代表アドバイザー  

    2001年 - 現在   

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    団体区分:その他

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  • 電力中央研究所低線量放射線生物影響連携研究プロジェクト 委員  

    1999年 - 2007年   

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論文

  • Association between radon hot spring bathing and health conditions: A cross-sectional study in Misasa, Japan 査読

    Takahiro Kataoka, Hiroshi Habu, Ayumi Tanaka, Shota Naoe, Kaito Murakami, Yuki Fujimoto, Ryohei Yukimine, Soshi Takao, Fumihiro Mitsunobu, Takashi Yorifuji, Kiyonori Yamaoka

    Acta Medica Okayama   77 ( 4 )   387 - 394   2023年8月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Okayama University Medical School  

    DOI: 10.18926/amo/65749

    CiNii Books

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  • Potential inhibitory effects of low-dose thoron inhalation and ascorbic acid administration on alcohol-induced hepatopathy in mice 査読

    Takahiro Kataoka, Tsuyoshi Ishida, Shota Naoe, Norie Kanzaki, Akihiro Sakoda, Hiroshi Tanaka, Fumihiro Mitsunobu, Kiyonori Yamaoka

    Journal of Radiation Research   63 ( 5 )   719 - 729   2022年9月

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    担当区分:最終著者, 責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Oxford University Press (OUP)  

    Abstract

    Although thoron inhalation exerts antioxidative effects in several organs, there are no reports on whether it inhibits oxidative stress-induced damage. In this study, we examined the combined effects of thoron inhalation and ascorbic acid (AA) administration on alcohol-induced liver damage. Mice were subjected to thoron inhalation at 500 or 2000 Bq/m3 and were administered 50% ethanol (alcohol) and 300 mg/kg AA. Results showed that although alcohol administration increased the levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) in the serum, the combination of thoron inhalation (500 Bq/m3) and AA administration 24 h after alcohol administration effectively inhibited alcohol-induced liver damage. The combination of thoron inhalation (500 Bq/m3) and AA administration 24 h after alcohol administration increased catalase (CAT) activity. Alcohol administration significantly decreased glutathione (GSH) levels in the liver. The GSH content in the liver after 2000 Bq/m3 thoron inhalation was lower than that after 500 Bq/m3 thoron inhalation. These findings suggest that the combination of thoron inhalation at 500 Bq/m3 and AA administration has positive effects on the recovery from alcohol-induced liver damage. The results also suggested that thoron inhalation at 500 Bq/m3 was more effective than that at 2000 Bq/m3, possibly because of the decrease in GSH content in the liver. In conclusion, the combination of thoron inhalation at 500 Bq/m3 and AA administration promoted an early recovery from alcohol-induced liver damage.

    DOI: 10.1093/jrr/rrac046

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  • Immunomodulatory effects of radon inhalation on lipopolysaccharide-induced inflammation in mice 査読

    Takahiro Kataoka, Shota Naoe, Kaito Murakami, Yuki Fujimoto, Ryohei Yukimine, Ayumi Tanaka, Kiyonori Yamaoka

    International Journal of Environmental Research and Public Health 19(17), 10632, 2022   19 ( 17 )   10632 - 10632   2022年8月

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    担当区分:最終著者, 責任著者   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/ijerph191710632

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  • Mechanisms of action of radon therapy on cytokine levels in normal mice and rheumatoid arthritis mouse model 査読

    Takahiro Kataoka, Shota Naoe, Kaito Murakami, Ryohei Yukimine, Yuki Fujimoto, Norie Kanzaki, Akihiro Sakoda, Fumihiro Mitsunobu, Kiyonori Yamaoka

    Journal of Clinical Biochemistry and Nutrition   70 ( 2 )   154 - 159   2022年3月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:The Society for Free Radical Research Japan  

    DOI: 10.3164/jcbn.21-91

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  • Confirmation of efficacy, elucidation of mechanism and new search for indications of radon therapy 査読

    Kiyonori Yamaoka, Takahiro Kataoka

    Journal of Clinical Biochemistry and Nutrition   70 ( 2 )   87 - 92   2022年3月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Radon inhalation decreases DNA damage induced by oxidative stress in mouse organs via the activation of antioxidative functions 査読 国際誌

    Takahiro Kataoka, Hina Shuto, Shota Naoe, Junki Yano, Norie Kanzaki, Akihiro Sakoda, Hiroshi Tanaka, Katsumi Hanamoto, Fumihiro Mitsunobu, Hiroaki Terato, Kiyonori Yamaoka

    Journal of Radiation Research   62 ( 5 )   861 - 867   2021年11月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Oxford University Press (OUP)  

    <title>Abstract</title>
    Radon inhalation decreases the level of lipid peroxide (LPO); this is attributed to the activation of antioxidative functions. This activation contributes to the beneficial effects of radon therapy, but there are no studies on the risks of radon therapy, such as DNA damage. We evaluated the effect of radon inhalation on DNA damage caused by oxidative stress and explored the underlying mechanisms. Mice were exposed to radon inhalation at concentrations of 2 or 20 kBq/m3 (for one, three, or 10 days). The 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels decreased in the brains of mice that inhaled 20 kBq/m3 radon for three days and in the kidneys of mice that inhaled 2 or 20 kBq/m3 radon for one, three or 10 days. The 8-OHdG levels in the small intestine decreased by approximately 20–40% (2 kBq/m3 for three days or 20 kBq/m3 for one, three or 10 days), but there were no significant differences in the 8-OHdG levels between mice that inhaled a sham treatment and those that inhaled radon. There was no significant change in the levels of 8-oxoguanine DNA glycosylase, which plays an important role in DNA repair. However, the level of Mn-superoxide dismutase (SOD) increased by 15–60% and 15–45% in the small intestine and kidney, respectively, following radon inhalation. These results suggest that Mn-SOD probably plays an important role in the inhibition of oxidative DNA damage.

    DOI: 10.1093/jrr/rrab069

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  • Evaluation of the redox state in mouse organs following radon inhalation 査読 国際誌

    Takahiro Kataoka, Norie Kanzaki, Akihiro Sakoda, Hina Shuto, Junki Yano, Shota Naoe, Hiroshi Tanaka, Katsumi Hanamoto, Hiroaki Terato, Fumihiro Mitsunobu, Kiyonori Yamaoka

    Journal of Radiation Research   62 ( 2 )   206 - 216   2021年3月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Oxford University Press (OUP)  

    <title>Abstract</title>
    Radon inhalation activates antioxidative functions in mouse organs, thereby contributing to inhibition of oxidative stress-induced damage. However, the specific redox state of each organ after radon inhalation has not been reported. Therefore, in this study, we evaluated the redox state of various organs in mice following radon inhalation at concentrations of 2 or 20 kBq/m3 for 1, 3 or 10 days. Scatter plots were used to evaluate the relationship between antioxidative function and oxidative stress by principal component analysis (PCA) of data from control mice subjected to sham inhalation. The results of principal component (PC) 1 showed that the liver and kidney had high antioxidant capacity; the results of PC2 showed that the brain, pancreas and stomach had low antioxidant capacities and low lipid peroxide (LPO) content, whereas the lungs, heart, small intestine and large intestine had high LPO content but low antioxidant capacities. Furthermore, using the PCA of each obtained cluster, we observed altered correlation coefficients related to glutathione, hydrogen peroxide and LPO for all groups following radon inhalation. Correlation coefficients related to superoxide dismutase in organs with a low antioxidant capacity were also changed. These findings suggested that radon inhalation could alter the redox state in organs; however, its characteristics were dependent on the total antioxidant capacity of the organs as well as the radon concentration and inhalation time. The insights obtained from this study could be useful for developing therapeutic strategies targeting individual organs.

    DOI: 10.1093/jrr/rraa129

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  • Comparison of antioxidative effects between radon and thoron inhalation in mouse organs. 査読 国際誌

    Yusuke Kobashi, Takahiro Kataoka, Norie Kanzaki, Tsuyoshi Ishida, Akihiro Sakoda, Hiroshi Tanaka, Yuu Ishimori, Fumihiro Mitsunobu, Kiyonori Yamaoka

    Radiation and Environmental Biophysics   59 ( 3 )   473 - 482   2020年8月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    Radon therapy has been traditionally performed globally for oxidative stress-related diseases. Many researchers have studied the beneficial effects of radon exposure in living organisms. However, the effects of thoron, a radioisotope of radon, have not been fully examined. In this study, we aimed to compare the biological effects of radon and thoron inhalation on mouse organs with a focus on oxidative stress. Male BALB/c mice were randomly divided into 15 groups: sham inhalation, radon inhalation at a dose of 500 Bq/m3 or 2000 Bq/m3, and thoron inhalation at a dose of 500 Bq/m3 or 2000 Bq/m3 were carried out. Immediately after inhalation, mouse tissues were excised for biochemical assays. The results showed a significant increase in superoxide dismutase and total glutathione, and a significant decrease in lipid peroxide following thoron inhalation under several conditions. Additionally, similar effects were observed for different doses and inhalation times between radon and thoron. Our results suggest that thoron inhalation also exerts antioxidative effects against oxidative stress in organs. However, the inhalation conditions should be carefully analyzed because of the differences in physical characteristics between radon and thoron.

    DOI: 10.1007/s00411-020-00843-0

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  • X-Irradiation at 0.5 Gy after the forced swim test reduces forced swimming-induced immobility in mice 査読 国際誌

    Takahiro Kataoka, Hina Shuto, Junki Yano, Shota Naoe, Tsuyoshi Ishida, Tetsuya Nakada, Keiko Yamato, Katsumi Hanamoto, Takaharu Nomura, Kiyonori Yamaoka

    Journal of Radiation Research   61 ( 4 )   517 - 523   2020年7月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Oxford University Press (OUP)  

    <title>Abstract</title>
    The forced swim test (FST) is a screening model for antidepressant activity; it causes immobility and induces oxidative stress. We previously reported that radon inhalation has antidepressant-like effects in mice potentially through the activation of antioxidative functions upon radon inhalation. This study aimed to investigate the effect of prior and post low-dose X-irradiation (0.1, 0.5, 1.0 and 2.0 Gy) on FST-induced immobility and oxidative stress in the mouse brain, and the differences, if any, between the two. Mice received X-irradiation before or after the FST repeatedly for 5 days. In the post-FST-irradiated group, an additional FST was conducted 4 h after the last irradiation. Consequently, animals receiving prior X-irradiation (0.1 Gy) had better mobility outcomes than sham-irradiated mice; however, their levels of lipid peroxide (LPO), an oxidative stress marker, remained unchanged. However, animals that received post-FST X-irradiation (0.5 Gy) had better mobility outcomes and their LPO levels were significantly lower than those of the sham-irradiated mice. The present results indicate that 0.5 Gy X-irradiation after FST inhibits FST-induced immobility and oxidative stress in mice.

    DOI: 10.1093/jrr/rraa022

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  • Comparative Effects of Radon Inhalation According to Mouse Strain and Cisplatin Dose in a Cisplatin-induced Renal Damage Model 査読

    Sasaoka Kaori, Kataoka Takahiro, Kanzaki Norie, Kobashi Yusuke, Sakoda Akihiro, Ishimori Yuu, Yamaoka Kiyonori

    Pakistan Journal of Zoology   50 ( 3 )   1157 - 1170   2018年6月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ZOOLOGICAL SOC PAKISTAN  

    Cisplatin (CDDP) is widely used for treating solid cancers; however, it induces nephrotoxicity caused by oxidative stress. Here, we investigated whether radon inhalation has different effects against CDDP-induced renal injury in two mouse strains differing in radiosensitivity, and determined the appropriate dose of CDDP combined with radon inhalation for highly radiosensitive mice. CDDP was administered at 20 mg/kg weight to C57BL/6J and BALB/c mice after radon inhalation at 1000 Bq/m(3) and 2000 Bq/m(3) for 24 h. Radon inhalation had a slight positive effect against CDDP toxicity in C57BL/6J mice with respect to improved hair condition, whereas radon inhalation exacerbated CDDP-induced toxicity in BALB/c mice, such as a decrease in hair condition, higher creatinine levels, and decreased antioxidant contents (catalase and glutathione). When BALB/c mice were treated with a lower dose of CDDP (15 mg/kg) after 1000 Bq/m(3) radon inhalation, the creatinine level was reduced and the superoxide dismutase content was increased, suggesting that this combination might have a protective effect against the CDDP-induced renal damage. The supportive effect of radon inhalation shows its good potential as a candidate treatment to alleviate CDDP-induced renal damage in veterinary medicine.

    DOI: 10.17582/journal.pjz/2018.50.3.1157.1170

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  • Radon inhalation induces manganese-superoxide dismutase in mouse brain via nuclear factor-κB activation 査読 国際誌

    Takahiro Kataoka, Reo Etani, Norie Kanzaki, Yusuke Kobashi, Yuto Yunoki, Tsuyoshi Ishida, Akihiro Sakoda, Yuu Ishimori, Kiyonori Yamaoka

    Journal of Radiation Research   58 ( 6 )   887 - 893   2017年12月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/jrr/rrx048

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  • Protective effects of hot spring water drinking and radon inhalation on ethanol-induced gastric mucosal injury in mice 査読 国際誌

    Reo Etani, Takahiro Kataoka, Norie Kanzaki, Akihiro Sakoda, Hiroshi Tanaka, Yuu Ishimori, Fumihiro Mitsunobu, Takehito Taguchi, Kiyonori Yamaoka

    Journal of Radiation Research   58 ( 5 )   614 - 625   2017年10月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OXFORD UNIV PRESS  

    Radon therapy using radon (Rn-222) gas is classified into two types of treatment: inhalation of radon gas and drinking water containing radon. Although short- or long-term intake of spa water is effective in increasing gastric mucosal blood flow, and spa water therapy is useful for treating chronic gastritis and gastric ulcer, the underlying mechanisms for and precise effects of radon protection against mucosal injury are unclear. In the present study, we examined the protective effects of hot spring water drinking and radon inhalation on ethanol-induced gastric mucosal injury in mice. Mice inhaled radon at a concentration of 2000 Bq/m(3) for 24 h or were provided with hot spring water for 2 weeks. The activity density of Rn-222 ranged from 663 Bq/l (start point of supplying) to 100 Bq/l (end point of supplying). Mice were then orally administered ethanol at three concentrations. The ulcer index (UI), an indicator of mucosal injury, increased in response to the administration of ethanol; however, treatment with either radon inhalation or hot spring water inhibited the elevation in the UI due to ethanol. Although no significant differences in antioxidative enzymes were observed between the radon-treated groups and the non-treated control groups, lipid peroxide levels were significantly lower in the stomachs of mice pre-treated with radon or hot spring water. These results suggest that hot spring water drinking and radon inhalation inhibit ethanol-induced gastric mucosal injury.

    DOI: 10.1093/jrr/rrx021

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  • Analysis of liver damage from radon, X-ray, or alcohol treatments in mice using a self-organizing map 査読 国際誌

    Norie Kanzaki, Takahiro Kataoka, Reo Etani, Kaori Sasaoka, Akihiro Kanagawa, Kiyonori Yamaoka

    Journal of Radiation Research   58 ( 1 )   33 - 40   2017年2月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Oxford University Press (OUP)  

    <title>Abstract</title>
    In our previous studies, we found that low-dose radiation inhibits oxidative stress–induced diseases due to increased antioxidants. Although these effects of low-dose radiation were demonstrated, further research was needed to clarify the effects. However, the analysis of oxidative stress is challenging, especially that of low levels of oxidative stress, because antioxidative substances are intricately involved. Thus, we proposed an approach for analysing oxidative liver damage via use of a self-organizing map (SOM)—a novel and comprehensive technique for evaluating hepatic and antioxidative function. Mice were treated with radon inhalation, irradiated with X-rays, or subjected to intraperitoneal injection of alcohol. We evaluated the oxidative damage levels in the liver from the SOM results for hepatic function and antioxidative substances. The results showed that the effects of low-dose irradiation (radon inhalation at a concentration of up to 2000 Bq/m3, or X-irradiation at a dose of up to 2.0 Gy) were comparable with the effect of alcohol administration at 0.5 g/kg bodyweight. Analysis using the SOM to discriminate small changes was made possible by its ability to ‘learn’ to adapt to unexpected changes. Moreover, when using a spherical SOM, the method comprehensively examined liver damage by radon, X-ray, and alcohol. We found that the types of liver damage caused by radon, X-rays, and alcohol have different characteristics. Therefore, our approaches would be useful as a method for evaluating oxidative liver damage caused by radon, X-rays and alcohol.

    DOI: 10.1093/jrr/rrw083

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  • Evaluating the protective effects of radon inhalation or ascorbic acid treatment after transient global cerebral ischemic injury in gerbils 査読

    Takahiro Kataoka, Reo Etani, Norie Kanzaki, Kaori Sasaoka, Yusuke Kobashi, Katsumi Hanamoto, Takehito Taguchi, Kiyonori Yamaoka

    Journal of Nuclear Science and Technology   53 ( 11 )   1681 - 1685   2016年11月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:TAYLOR & FRANCIS LTD  

    In this study, we compared the protective effects of radon inhalation and ascorbic acid administration on transient global cerebral ischemic injury in gerbils. Gerbils were treated with radon inhalation (2000 Bq/m(3), 24 hours) or ascorbic acid (100, 300, or 500mg/kg body weight). Then, transient global cerebral ischemia was induced by bilateral occlusion of the common carotid artery. Results showed that the number of damaged neurons was significantly increased in gerbils that underwent ischemia compared with that in control gerbils. However, the number of damaged neurons in gerbils treated with radon or 500mg/kg of ascorbic acid before ischemia was significantly lower than gerbils who were subjected to ischemia without any pretreatment, and the protective effects of radon inhalation were similar to the effects of administering 500mg/kg ascorbic acid. The levels of superoxide dismutase (SOD) and total glutathione (t-GSH) in brain tissue were increased to a similar extent by pretreatment with radon inhalation or 500mg/kg of ascorbic acid. These findings suggested that radon inhalation has a protective antioxidative effect against transient global cerebral ischemic injury similar to 500mg/kg ascorbic acid treatment.

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  • Radon inhalation suppresses nephropathy in streptozotocin-induced type-1 diabetic mice 査読

    Yuichi Nishiyama, Takahiro Kataoka, Keiko Yamato, Reo Etani, Takehito Taguchi, Kiyonori Yamaoka

    Journal of Nuclear Science and Technology   53 ( 6 )   909 - 915   2016年6月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:TAYLOR & FRANCIS LTD  

    In this study, we investigated the suppressive effects of radon inhalation against nephropathy in C57BL/6J mice with type-1 diabetes induced by intraperitoneal injection of streptozotocin (50 mg/kg weight, given five times). Four weeks after diabetes induction, the diabetic mice were continuously treated with inhaled radon-222 of 2000 Bq/m(3) or air only (sham) for four weeks. The results showed that radon inhalation did not affect type-1 diabetic symptoms such as body weight loss, hyperglycemia, and hypoinsulinemia. However, diabetic mice treated with radon showed lower urinary albumin excretion and fibrotic change in renal glomeruli compared with diabetic mice not treated with radon. Furthermore, renal superoxide dismutase activity and glutathione content were significantly higher in diabetic mice treated with radon than in diabetic mice not treated with radon. These findings suggested that radon inhalation enhanced renal antioxidants activities, resulting in the suppression of diabetic nephropathy. This study may contribute to the development of a novel approach in the treatment of nephropathy for diabetic patients.

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  • Difference in the action mechanism of radon inhalation and radon hot spring water drinking in suppression of hyperuricemia in mice 査読 国際誌

    Reo Etani, Takahiro Kataoka, Norie Kanzaki, Akihiro Sakoda, Hiroshi Tanaka, Yuu Ishimori, Fumihiro Mitsunobu, Kiyonori Yamaoka

    Journal of Radiation Research   57 ( 3 )   250 - 257   2016年6月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OXFORD UNIV PRESS  

    Although radon therapy is indicated for hyperuricemia, the underlying mechanisms of action have not yet been elucidated in detail. Therefore, we herein examined the inhibitory effects of radon inhalation and hot spring water drinking on potassium oxonate (PO)-induced hyperuricemia in mice. Mice inhaled radon at a concentration of 2000 Bq/m(3) for 24 h or were given hot spring water for 2 weeks. Mice were then administrated PO at a dose of 500 mg/kg. The results obtained showed that serum uric acid levels were significantly increased by the administration of PO. Radon inhalation or hot spring water drinking significantly inhibited elevations in serum uric acid levels through the suppression of xanthine oxidase activity in the liver. Radon inhalation activated anti-oxidative functions in the liver and kidney. These results suggest that radon inhalation inhibits PO-induced hyperuricemia by activating anti-oxidative functions, while hot spring water drinking may suppress PO-induced elevations in serum uric acid levels through the pharmacological effects of the chemical compositions dissolved in it.

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  • Activation of Antioxidative Functions by Radon Inhalation Enhances the Mitigation Effects of Pregabalin on Chronic Constriction Injury-Induced Neuropathic Pain in Mice 査読 国際誌

    Takahiro Kataoka, Shunsuke Horie, Reo Etani, Norie Kanzaki, Kaori Sasaoka, Yusuke Kobashi, Katsumi Hanamoto, Kiyonori Yamaoka

    Oxidative Medicine and Cellular Longevity   Article ID 9853692   1 - 8   2016年

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:HINDAWI LTD  

    Radon inhalation brings pain relief for chronic constriction injury- (CCI-) induced neuropathic pain in mice due to the activation of antioxidative functions, which is different from the mechanism of the pregabalin effect. In this study, we assessed whether a combination of radon inhalation and pregabalin administration is more effective against neuropathic pain than radon or pregabalin only. Mice were treated with inhaled radon at a concentration of 1,000 Bq/m(3) for 24 hours and pregabalin administration after CCI surgery. In mice treated with pregabalin at a dose of 3 mg/kg weight, the 50% paw withdrawal threshold of mice treated with pregabalin or radon and pregabalin was significantly increased, suggesting pain relief. The therapeutic effects of radon inhalation or the combined effects of radon and pregabalin (3 mg/kg weight) were almost equivalent to treatment with pregabalin at a dose of 1.4 mg/kg weight or 4.1 mg/kg weight, respectively. Radon inhalation and the combination of radon and pregabalin increased antioxidant associated substances in the paw. The antioxidant substances increased much more in radon inhalation than in pregabalin administration. These findings suggested that the activation of antioxidative functions by radon inhalation enhances the pain relief of pregabalin and that this combined effect is probably an additive effect.

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  • Combined effects of radon inhalation and antioxidant vitamin administration on acute alcohol-induced hepatopathy in mice 査読

    Reo Etani, Takahiro Kataoka, Yuichi Nishiyama, Yuji Takata, Kiyonori Yamaoka

    Journal of Nuclear Science and Technology   52 ( 12 )   1512 - 1518   2015年12月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:TAYLOR & FRANCIS LTD  

    It has been reported that radon inhalation activates antioxidative functions in liver and has an antioxidative effect against hepatopathy similar to that of the antioxidative effects of ascorbic acid (VC) or -tocopherol (VE). In this study, we examined the combined effects of radon inhalation and antioxidant vitamin administration on acute alcohol-induced hepatopathy in mice. ICR mice were subjected to intraperitoneal (i.p.) administration of alcohol after pretreating with air only (sham) or radon at a concentration of approximately 2000 Bq/m(3) for 24 hours and i.p. administration of VC (300 mg/kg body weight) or VE (300 mg/kg body weight). In mice injected with alcohol, the combined radon and antioxidant vitamins treatment significantly decreased the activities of glutamic oxaloacetic transaminase in serum compared to not only the alcohol-administered group (sham group), but also the radon inhalation with alcohol administration group or the vitamin and alcohol administration group. In addition, radon inhalation significantly increased the antioxidant level, in such as the catalase activity and the total glutathione content in liver compared to the sham group. These results suggested that the combined radon and antioxidant vitamin treatment could effectively inhibit alcohol-induced hepatopathy in mice without any antagonizing action.

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  • Recent studies on anti-inflammatory effects of radon inhalation in mice 査読

    Norie Kanzaki, Takahiro Kataoka, Reo Etani, Kiyonori Yamaoka

    Inflammation & Cell Signaling   1 ( 6 )   1 - 5   2015年12月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Radon Inhalation Protects Against Transient Global Cerebral Ischemic Injury in Gerbils 査読 国際誌

    Takahiro Kataoka, Reo Etani, Yuji Takata, Yuichi Nishiyama, Atsushi Kawabe, Masayuki Kumashiro, Takehito Taguchi, Kiyonori Yamaoka

    Inflammation   37 ( 5 )   1675 - 1682   2014年10月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER/PLENUM PUBLISHERS  

    Although brain disorders are not the main indication for radon therapy, our previous study suggested that radon inhalation therapy might mitigate brain disorders. In this study, we assessed whether radon inhalation protects against transient global cerebral ischemic injury in gerbils. Gerbils were treated with inhaled radon at a concentration of 2,000 Bq/m(3) for 24 h. After radon inhalation, transient global cerebral ischemia was induced by bilateral occlusion of the common carotid artery. Results showed that transient global cerebral ischemia induced neuronal damage in hippocampal CA1, and the number of damaged neurons was significantly increased compared with control. However, radon treatment inhibited ischemic damage. Superoxide dismutase (SOD) activity in the radon-treated gerbil brain was significantly higher than that in sham-operated gerbils. These findings suggested that radon inhalation activates antioxidative function, especially SOD, thereby inhibiting transient global cerebral ischemic injury in gerbils.

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  • Effects of cream containing ultralow volume radionuclides on carrageenan-induced inflammatory paw edema in mice 査読

    Takahiro Kataoka, Yuji Takata, Reo Etani, Yuichi Nishiyama, Atsushi Kawabe, Katsumi Hanamoto, Takehito Taguchi, Kiyonori Yamaoka

    Biochemistry and Physiology   3 ( 2 )   133 - 137   2014年4月

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    担当区分:最終著者, 責任著者  

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  • Preventive and curative effects of radon inhalation on chronic constriction injury-induced neuropathic pain in mice 査読

    K. Yamato, T. Kataoka, Y. Nishiyama, T. Taguchi, K. Yamaoka

    European Journal of Pain   17 ( 4 )   480 - 492   2013年4月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    Background Radon therapy is clinically useful for the treatment of pain-related diseases. However, there have been no studies regarding the effects of radon inhalation on neuropathic pain. In this study, we aimed to determine whether radon inhalation actually induced a remission of neuropathic pain and improved the quality of life. Methods First, we investigated the antinociceptive effects of radon inhalation in the chronic constriction injury (CCI) model of neuropathic pain. We evaluated pain behaviour in mice before and after CCI surgery, using von Frey test. Pretreated mice received CCI surgery immediately after 24-h inhalation of radon at background (BG) concentration (c. 19Bq/m3), or at a concentration of 1000 or 2000Bq/m3, and post-treated mice inhaled similar levels of radon 2 days after CCI surgery. Results CCI surgery induced mechanical allodynia and hyperalgesia on a plantar surface of mice, as assessed using von Frey test, and 2000Bq/m3 radon inhalation alleviated hyperalgesic conditions 2237% compared to BG level concentration. Concurrently, CCI surgery increased norepinephrine (NE), tumour necrosis factor-alpha (TNF-) and nitric oxide (NO) concentrations in plasma, and leukocyte migration in paws. Furthermore, CCI-induced neuropathy reduced superoxide dismutase (SOD) activity. Treatment with radon inhalation, specifically at a concentration of 2000Bq/m3, produced antinociceptive effects, i.e., lowered plasma TNF-, NE and NO levels and restored SOD activity, as well as pain-related behaviour. Conclusions This study showed that inhalation of 2000Bq/m3 radon prevented and alleviated CCI-induced neuropathic pain in mice.

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  • Antinociceptive Effects of Radon Inhalation on Formalin-Induced Inflammatory Pain in Mice 査読 国際誌

    Keiko Yamato, Takahiro Kataoka, Yuichi Nishiyama, Takehito Taguchi, Kiyonori Yamaoka

    Inflammation   36 ( 2 )   355 - 363   2013年4月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER/PLENUM PUBLISHERS  

    Radon therapy is clinically useful for the treatment of inflammatory diseases. The mechanisms of pain relief remain to be fully elucidated. In this study, we investigated the antinociceptive effects of radon inhalation in a mouse model of formalin-induced inflammatory pain. Immediately, after radon inhalation at a concentration of background level (ca. 19 Bq/m(3)), 1,000 or 2,000 Bq/m(3) for 24 h, 1.35 % formalin (0.5 % formaldehyde in saline, 20 mu l) was subcutaneously injected into the hind paw of mice, and we measured licking response time. Radon inhalation inhibited the second phase of response in formalin test. Formalin administration induced nociception and increased tumor necrosis factor alpha (TNF-alpha) and nitric oxide (NO) levels in serum and leukocyte migration in paws. Concurrently, formalin injection decreased antioxidative functions. Radon inhalation produced antinociceptive effects, i.e., lowered serum TNF-alpha and NO levels, and restored antioxidative functions. The results showed that radon inhalation inhibited formalin-induced inflammatory pain.

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  • Suppression of streptozotocin-induced type-1 diabetes in mice by radon inhalation 査読

    Y. Nishiyama, T. Kataoka, J. Teraoka, A. Sakoda, H. Tanaka, Y. Ishimori, F. Mitsunobu, T. Taguchi, K. Yamaoka

    Physiological Research   62 ( 1 )   57 - 66   2013年1月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We examined the protective effect of radon inhalation on streptozotocin (STZ)-induced type-1 diabetes in mice. Mice inhaled radon at concentrations of 1000, 2500, and 5500 Bq/m3 for 24 hours before STZ administration. STZ administration induced characteristics of type-1 diabetes such as hyperglycemia and hypoinsulinemia
    however, radon inhalation at doses of 1000 and 5500 Bq/m3 significantly suppressed the elevation of blood glucose in diabetic mice. Serum insulin was significantly higher in mice pre-treated with radon at a dose of 1000 Bq/m3 than in mice treated with a sham. In addition, superoxide dismutase activities and total glutathione contents were significantly higher and lipid peroxide was significantly lower in mice pre-treated with radon at doses of 1000 and 5500 Bq/m3 than in mice treated with a sham. These results were consistent with the result that radon inhalation at 1000 and 5500 Bq/m3 suppressed hyperglycemia. These findings suggested that radon inhalation suppressed STZ-induced type-1 diabetes through the enhancement of antioxidative functions in the pancreas. © 2013 Institute of Physiology v.v.i., Academy of Sciences of the Czech Republic, Prague, Czech Republic.

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  • Comparative study on the inhibitory effects of antioxidant vitamins and radon on carbon tetrachloride-induced Hepatopathy 査読 国際誌

    Takahiro Kataoka, Yuichi Nishiyama, Keiko Yamato, Junichi Teraoka, Yuji Morii, Akihiro Sakoda, Yuu Ishimori, Takehito Taguchi, Kiyonori Yamaoka

    Journal of Radiation Research   53 ( 6 )   830 - 839   2012年11月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OXFORD UNIV PRESS  

    We have previously reported that radon inhalation activates anti-oxidative functions and inhibits carbon tetrachloride (CCl4)-induced hepatopathy. It has also been reported that antioxidant vitamins can inhibit CCl4-induced hepatopathy. In the current study, we examined the comparative efficacy of treatment with radon, ascorbic acid and alpha-tocopherol on CCl4-induced hepatopathy. Mice were subjected to intraperitoneal injection of CCl4 after inhaling approximately 1000 or 2000 Bq/m(3) radon for 24 h, or immediately after intraperitoneal injection of ascorbic acid (100, 300, or 500 mg/kg bodyweight) or alpha-tocopherol (100, 300, or 500 mg/kg bodyweight). We estimated the inhibitory effects on CCl4-induced hepatopathy based on hepatic function-associated parameters, oxidative damage-associated parameters and histological changes. The results revealed that the therapeutic effects of radon inhalation were almost equivalent to treatment with ascorbic acid at a dose of 500 mg/kg or alpha-tocopherol at a dose of 300 mg/kg. The activities of superoxide dismutase, catalase, and glutathione peroxidase in the liver were significantly higher in mice exposed to radon than in mice treated with CCl4 alone. These findings suggest that radon inhalation has an anti-oxidative effect against CCl4-induced hepatopathy similar to the anti-oxidative effects of ascorbic acid or alpha-tocopherol due to the induction of anti-oxidative functions.

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  • Comparative study on the inhibitory effects of α-tocopherol and radon on carbon tetrachloride-induced renal damage 査読 国際誌

    T.Kataoka, K.Yamato, Y.Nishiyama, Yuji Morii, Reo Etani, Yuji Takata, K.Hanamoto, A.Kawabe, A.Sakoda, Y.Ishimori, T.Taguchi, K.Yamaoka

    Renal Failure   34 ( 9 )   1181 - 1187   2012年9月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3109/0886022X.2012.717496

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  • Radioactivity of Pb-210 in Japanese cigarettes and radiation dose from smoking inhalation 査読

    A. Sakoda, K. Fukao, A. Kawabe, T. Kataoka, K. Hanamoto, K. Yamaoka

    Radiation Protection Dosimetry   150 ( 1 )   109 - 113   2012年6月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OXFORD UNIV PRESS  

    It is well known that cigarette tobaccos contain naturally occurring radioactive nuclides such as Pb-210 and Po-210. In many countries, the radioactivity of tobaccos has been measured to estimate the effective dose from smoking inhalation. The present study covered 24 cigarette brands including the top 20 of sales in Japan between April 2008 and March 2009. The activity concentrations of Pb-210 were measured by gamma-ray spectrometry, and then those of its progeny (Po-210) were evaluated assuming the radioactive equilibrium between the two nuclides. Their concentrations were in the range of 214 mBq cigarette(1) with an arithmetic mean of 83 mBq cigarette(1). The annual committed effective doses were also calculated, based on the scenario that a smoker consumes 20 cigarettes a day. The average doses from Pb-210 and Po-210 inhalations were 229 and 6827 Sv y(1), respectively.

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  • Study on effects of thoron and thermal treatment for aging-related diseases in humans 査読

    Y. Aoyama, T. Kataoka, S. Nakagawa, A. Sakoda, Y. Ishimori, F. Mitsunobu, K. Yamaoka

    Iranian Journal of Radiation Research   9 ( 4 )   221 - 229   2012年4月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:IJRR-IRANIAN JOURNAL RADIATION RES  

    Background: The aim of this study was to analyze the effects of thoron and thermal treatment for aging-related diseases in humans. Materials and Methods: All subjects inhaled thoron with a high concentration (about 4900 Bq/m(3)) for 2 weeks. Blood pressures were measured and blood samples were collected after each treatment 1, 2 and 3 weeks after the first treatment. Results: The alpha-atrial natriuretic peptide level of the rheumatoid arthritis group was increased and the blood pressure was significantly decreased. Superoxide dismutase activity of rheumatoid arthritis group was significantly increased by treatment. In addition, thoron and thermal treatment significantly enhanced the concanavalin A-induced mitogen response and increased the level of CD4-positive cells; it decreased the level of CD8-positive cells. The results suggest that thoron and thermal treatment activates antioxidative function. Furthermore, these findings suggest that thoron and thermal treatment prevents diabetic ketoacidosis and contributes to the prevention of aging-related diseases. Conclusion: Thoron and thermal therapy may be part of the mechanism for the alleviation of diabetes mellitus and rheumatoid arthritis. Iran. J. Radiat. Res., 2012; 9(4): 221-229

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  • Protective Effects of Radon Inhalation on Carrageenan-Induced Inflammatory Paw Edema in Mice 査読

    Takahiro Kataoka, Junichi Teraoka, Akihiro Sakoda, Yuichi Nishiyama, Keiko Yamato, Mayuko Monden, Yuu Ishimori, Takaharu Nomura, Takehito Taguchi, Kiyonori Yamaoka

    Inflammation   35 ( 2 )   713 - 722   2012年4月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER/PLENUM PUBLISHERS  

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  • Inhibitory Effects of Pretreatment with Radon on Acute Alcohol-Induced Hepatopathy in Mice 査読 国際誌

    Teruaki Toyota, Takahiro Kataoka, Yuichi Nishiyama, Takehito Taguchi, Kiyonori Yamaoka

    Mediators of Inflammation   2012 ( 382801 )   1 - 10   2012年3月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:HINDAWI PUBLISHING CORPORATION  

    We previously reported that radon inhalation activates antioxidative functions in the liver and inhibits carbon tetrachloride-induced hepatopathy in mice. In addition, it has been reported that reactive oxygen species contribute to alcohol-induced hepatopathy. In this study, we examined the inhibitory effects of radon inhalation on acute alcohol- induced hepatopathy in mice. C57BL/6J mice were subjected to intraperitoneal injection of 50% alcohol (5 g/kg bodyweight) after inhaling approximately 4000 Bq/m(3) radon for 24 h. Alcohol administration significantly increased the activities of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT) in serum, and the levels of triglyceride and lipid peroxide in the liver, suggesting acute alcohol- induced hepatopathy. Radon inhalation activated antioxidative functions in the liver. Furthermore, pretreatment with radon inhibited the depression of hepatic functions and antioxidative functions. These findings suggested that radon inhalation activated antioxidative functions in the liver and inhibited acute alcohol- induced hepatopathy in mice.

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  • Suppression of Dextran Sulfate Sodium-Induced Colitis in Mice by Radon Inhalation 査読 国際誌

    Yuichi Nishiyama, Takahiro Kataoka, Keiko Yamato, Takehito Taguchi, Kiyonori Yamaoka

    Mediators of Inflammation   2012 ( 239617 )   1 - 11   2012年2月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:HINDAWI LTD  

    The enhanced release of reactive oxygen species from activated neutrophils plays important role in the pathogenesis of inflammatory bowel disease. We previously reported that radon inhalation activates antioxidative functions in various organs of mice. In this study, we examined the protective effects of radon inhalation on dextran sulfate sodium- (DSS) induced colitis in mice which were subjected to DSS for 7 days. Mice were continuously treated with air only (sham) or radon at a concentration of 2000 Bq/m(3) from a day before DSS administration to the end of colitis induction. In the results, radon inhalation suppressed the elevation of the disease activity index score and histological damage score induced by DSS. Based on the changes in tumor necrosis factor-alpha in plasma and myeloperoxidase activity in the colon, it was shown that radon inhalation suppressed DSS-induced colonic inflammation. Moreover, radon inhalation suppressed lipid peroxidation of the colon induced by DSS. The antioxidant level (superoxide dismutase and total glutathione) in the colon after DSS administration was significantly higher in mice treated with radon than with the sham. These results suggested that radon inhalation suppressed DSS-induced colitis through the enhancement of antioxidative functions in the colon.

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  • Inhibitory Effects of Prior Low-dose X-irradiation on Cold-induced Brain Injury in Mouse 査読 国際誌

    Masaaki Yoshimoto, Takahiro Kataoka, Teruaki Toyota, Takehito Taguchi, Kiyonori Yamaoka

    Inflammation   35 ( 1 )   89 - 97   2012年2月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER/PLENUM PUBLISHERS  

    We examined the inhibitory effects of low-dose X-irradiation on mouse brain tissue with cold-induced injury by comparing tissue samples from three groups of mice: control, sham-irradiated cold-exposed, and X-ray-irradiated (0.5 Gy) cold-exposed mice. The water content in brain increased significantly in the sham-irradiated group following the cold-induced injury relative to the control group. However, water content in brain tissue from the X-ray-irradiated group was significantly lower than that from the sham-irradiated group. Levels of antioxidants, such as superoxide dismutase and glutathione, in brain tissue from the X-ray-irradiated group were higher than those from the sham-irradiated group. Moreover, the cold injury-induced cell death, particularly apoptosis, while low-dose irradiation inhibited cell death, especially among glial cells, but not numeral cells. These findings suggest that prior low-dose X-irradiation activated antioxidant function and inhibited cold-induced brain injury.

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  • Radon Inhalation Protects Mice from Carbon-Tetrachloride-Induced Hepatic and Renal Damage 査読 国際誌

    Takahiro Kataoka, Yuichi Nishiyama, Teruaki Toyota, Masaaki Yoshimoto, Akihiro Sakoda, Yuu Ishimori, Yutaka Aoyama, Takehito Taguchi, Kiyonori Yamaoka

    Inflammation   34 ( 6 )   559 - 567   2011年12月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER/PLENUM PUBLISHERS  

    We assessed whether radon inhalation provided protection from carbon tetrachloride (CCl4)-induced hepatic and renal damage in mice. Mice were subjected to intraperitoneal injection of CCl4 after inhaling approximately 18 kBq/m(3) radon for 6 h. Radon inhalation significantly increased total glutathione (t-GSH) content and glutathione peroxidase (GPx) activity in the liver and kidney. Injection of CCl4 was associated with significantly higher levels of glutamic oxaloacetic transaminase (GOT) and alkaline phosphatase (ALP) activity and creatinine level in serum, and pretreatment with radon significantly decreased the GOT and ALP activity and creatinine level associated with CCl4 injection, suggesting that radon inhalation alleviates CCl4-induced hepatic and renal damage. The t-GSH contents and GPx activity in the liver and kidney of animals pretreated with radon were significantly higher than those of the CCl4-only group. These findings suggested that radon inhalation activated antioxidative functions and inhibited CCl4-induced hepatic and renal damage in mice.

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  • Study of the Response of Superoxide Dismutase in Mouse Organs to Radon Using a New Large-scale Facility for Exposing Small Animals to Radon 査読 国際誌

    Takahiro Kataoka, Akihiro Sakoda, Yuu Ishimori, Teruaki Toyota, Yuichi Nishiyama, Hiroshi Tanaka, Fumihiro Mitsunobu, Kiyonori Yamaoka

    Journal of Radiation Research   52 ( 6 )   775 - 781   2011年11月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN RADIATION RESEARCH SOC  

    We examined dose dependent or dose rate dependent changes of superoxide dismutase (SOD) activity using a new large-scale facility for exposing small animals to radon. Mice were exposed to radon at a concentration of 250, 500, 1000, 2000, or 4000 Bq/m(3) for 0.5, 1, 2, 4, or 8 days. When mice were exposed to radon at 2000 day.Bq/m(3), activation of SOD activities in plasma, liver, pancreas, heart, thymus, and kidney showed dose rate effects. Our results also suggested that continuous exposure to radon increased SOD activity, but SOD activity transiently returned to normal levels at around 2 days. Moreover, we classified the organs into four groups (1. plasma, brain, lung; 2. heart, liver, pancreas, small intestine; 3. kidney, thymus; 4. stomach) based on changes in SOD activity. Thymus had the highest responsiveness and stomach had lowest. These data provide useful baseline measurements for future studies on, radon effects.

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  • A comprehensive review of radon emanation measurements for mineral, rock, soil, mill tailing and fly ash 査読 国際誌

    Akihiro Sakoda, Yuu Ishimori, Kiyonori Yamaoka

    Applied Radiation and Isotopes   69 ( 10 )   1422 - 1435   2011年10月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    To our knowledge, this paper is the most comprehensive review to cover most studies, published in the past three decades at least, of radon emanation measurements. The radon emanation fraction, a possibility of radon atoms generated in a material escaping from its grains, has been widely measured for a variety of materials. The aim of this review is to organize a huge number of such data accumulated. The representative values of the emanation fraction for minerals, rocks, soils, mill tailings and fly ashes were derived to be 0.03, 0.13, 0.20, 0.17 and 0.03, respectively. Current knowledge of the emanation processes was also summarized to discuss their affected factors. (C) 2011 Elsevier Ltd. All rights reserved.

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  • A comprehensive review of radon emanation measurements for mineral, rock, soil, mill tailing and fly ash 査読 国際誌

    A.Sakoda, Y.Ishimori, K.Yamaoka

    Applied Radiation and Isotopes   69 ( 10 )   1422 - 1435   2011年10月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    To our knowledge, this paper is the most comprehensive review to cover most studies, published in the past three decades at least, of radon emanation measurements. The radon emanation fraction, a possibility of radon atoms generated in a material escaping from its grains, has been widely measured for a variety of materials. The aim of this review is to organize a huge number of such data accumulated. The representative values of the emanation fraction for minerals, rocks, soils, mill tailings and fly ashes were derived to be 0.03, 0.13, 0.20, 0.17 and 0.03, respectively. Current knowledge of the emanation processes was also summarized to discuss their affected factors.

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  • Studies on possibility for alleviation of lifestyle diseases by low-dose irradiation or radon inhalation 査読 国際誌

    Takahiro Kataoka, Akihiro Sakoda, Masaaki Yoshimoto, Shinya Nakagawa, Teruaki Toyota, Yuichi Nishiyama, Keiko Yamato, Yuu Ishimori, Atsushi Kawabe, Katsumi Hanamoto, Takehito Taguchi, Kiyonori Yamaoka

    Radiation Protection Dosimetry   146 ( 1-3 )   360 - 363   2011年7月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OXFORD UNIV PRESS  

    Our previous studies showed the possibility that activation of the antioxidative function alleviates various oxidative damages, which are related to lifestyle diseases. Results showed that, low-dose X-ray irradiation activated superoxide dismutase and inhibits oedema following ischaemia-reperfusion. To alleviate ischaemia-reperfusion injury with transplantation, the changes of the antioxidative function in liver graft using low-dose X-ray irradiation immediately after exenteration were examined. Results showed that liver grafts activate the antioxidative function as a result of irradiation. In addition, radon inhalation enhances the antioxidative function in some organs, and alleviates alcohol-induced oxidative damage of mouse liver. Moreover, in order to determine the most effective condition of radon inhalation, mice inhaled radon before or after carbon tetrachloride (CCl(4)) administration. Results showed that radon inhalation alleviates CCl(4)-induced hepatopathy, especially prior inhalation. It is highly possible that adequate activation of antioxidative functions induced by low-dose irradiation can contribute to preventing or reducing oxidative damages, which are related to lifestyle diseases.

    DOI: 10.1093/rpd/ncr189

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  • Differences of natural radioactivity and radon emanation fraction between constituent minerals of rock or soil 査読 国際誌

    Akihiro Sakoda, Yuichi Nishiyama, Katsumi Hanamoto, Yuu Ishimori, Yuki Yamamoto, Takahiro Kataoka, Atsushi Kawabe, Kiyonori Yamaoka

    Applied Radiation and Isotopes   68 ( 6 )   1180 - 1184   2010年12月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    We examined differences in the radioactive characteristics among the main minerals forming granite materials. Using a non-toxic high-density agent, minerals were separated from rock (granite-gneiss) and soil (weathered granite) samples. The natural radioactivity ((238)U and (226)Ra) and radon emanation fraction of the minerals were then studied by gamma-ray spectrometry. The radon emanation fractions (27-43%) of the minerals from the soil were much higher than those (0.6-4.6%) of the rock minerals. Additionally, the emanation fractions differed greatly among the minerals separated from both the bulk rock and soil. These results were discussed in terms of the differences of surface area and radium distribution in the mineral grains. It was noticeable that a higher emanation fraction than expected for quartz was commonly observed in the rock and soil samples. We then estimated the contribution of each constituent mineral to the total radon exhalation from the bulk samples. The result depended not only on the radon emanation fraction, but also on the (226)Ra activity and the mineral content. Furthermore, using the obtained data, we also discussed the effect of grain size on radon emanation and why this has been reported to vary markedly in previous studies.

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  • Applicability and performance of an imaging plate at subzero temperatures 査読 国際誌

    Akihiro Sakoda, Yuu Ishimori, Katsumi Hanamoto, Atsushi Kawabe, Takahiro Kataoka, Tomohiro Nagamatsu, Kiyonori Yamaoka

    Applied Radiation and Isotopes   68 ( 10 )   2013 - 2015   2010年10月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    The performance of imaging plates (IPs) has not been studied at temperatures lower than 0 degrees C. In the present study, an IP was irradiated with gamma rays emitted from the mineral monazite at temperatures between -80 and 30 degrees C to determine its fundamental properties. The IP response as a function of irradiation time was found to be linear, suggesting that the IP works properly at low temperatures. Fading, an effect which should be considered at temperatures of more than 0 degrees C, was not observed at -30 and 80 degrees C. Furthermore, the fading-corrected PSL value of the IP irradiated at 80 degrees C was lower than at other temperatures (30.5 and -30 degrees C). This can be explained by thermostimulated luminescence (TSL). Since the only intensive TSL peak in the temperature range from -80 to 30 degrees C is present at about -43 degrees C, some of the electrons trapped at F centers recombine with holes through the process of TSL before the stored radiation image is read out at room temperature. This finding suggests that the apparent sensitivity of the IP is lower at -80 degrees C although it is similar to sensitivities between -30 and 30 degrees C. This low sensitivity should be corrected to perform quantitative measurements. (C) 2010 Elsevier Ltd. All rights reserved.

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  • Physiologically Based Pharmacokinetic Modeling of Inhaled Radon to Calculate Absorbed Doses in Mice, Rats, and Humans 査読

    Akihiro Sakoda, Yuu Ishimori, Atsushi Kawabe, Takahiro Kataoka, Katsumi Hanamoto, Kiyonori Yamaoka

    Journal of Nuclear Science and Technology   47 ( 8 )   731 - 738   2010年8月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:TAYLOR & FRANCIS LTD  

    This is the first report to provide radiation doses, arising from inhalation of radon itself, in mice and rats. To quantify absorbed doses to organs and tissues in mice, rats, and humans, we computed the behavior of inhaled radon in their bodies on the basis of a physiologically based pharmacokinetic (PBPK) model. It was assumed that radon dissolved in blood entering the gas exchange compartment is transported to any tissue by the blood circulation to be instantaneously distributed according to a tissue/blood partition coefficient. The calculated concentrations of radon in the adipose tissue and red bone marrow following its inhalation were much higher than those in the others, because of the higher partition coefficients. Compared with a previous experimental data for rats and model calculation for humans, the present calculation was proved to be valid. Absorbed dose rates to organs and tissues were estimated to be within the range of 0.04-1.4 nGy (Bq m(-3))(-1) day(-1) for all the species. Although the dose rates are not so high, it may be better to pay attention to the dose to the red bone marrow from the perspective of radiation protection. For more accurate dose assessment, it is necessary to update tissue/blood partition coefficients of radon that strongly govern the result of the PBPK modeling.

    DOI: 10.1080/18811248.2010.9711649

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  • First model of the effect of grain size on radon emanation 査読 国際誌

    Akihiro Sakoda, Katsumi Hanamoto, Yuu Ishimori, Takahiro Kataoka, Atsushi Kawabe, Kiyonori Yamaoka

    Applied Radiation and Isotopes   68 ( 6 )   1169 - 1172   2010年6月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    The present model represents an improvement on previous models of radon emanation from soil by incorporating soil grain size in addition to moisture. Monte Carlo simulation was employed in the calculation since it was difficult to mathematically express the radon emanation fraction for the present soil model. Grain size is one of the most important factors in describing the properties of soil. Grain size was demonstrated to affect the radon emanation fraction, depending on moisture content. Although the emanation fraction is generally considered to be proportional to grain size, the result of the model calculation suggested that the effect of grain size is not so simple. This study should serve as an initial step toward improving the modeling of this radon emanation. (C) 2010 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.apradiso.2009.11.070

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  • Differences of natural radioactivity and radon emanation fraction among constituent minerals of rock or soil 査読

    Akihiro Sakoda, Yuichi Nishiyama, Katsumi Hanamoto, Yuu Ishimori, Yuki Yamamoto, Takahiro Kataoka, Atsushi Kawabe, Kiyonori Yamaoka

    Applied Radiation and Isotopes   68 ( 6 )   1180 - 1184   2010年6月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    We examined differences in the radioactive characteristics among the main minerals forming granite materials. Using a non-toxic high-density agent, minerals were separated from rock (granite-gneiss) and soil (weathered granite) samples. The natural radioactivity (U-238 and Ra-226) and radon emanation fraction of the minerals were then studied by gamma-ray spectrometry. The radon emanation fractions (27-43%) of the minerals from the soil were much higher than those (0.6-4.6%) of the rock minerals. Additionally, the emanation fractions differed greatly among the minerals separated from both the bulk rock and soil. These results were discussed in terms of the differences of surface area and radium distribution in the mineral grains. It was noticeable that a higher emanation fraction than expected for quartz was commonly observed in the rock and soil samples. We then estimated the contribution of each constituent mineral to the total radon exhalation from the bulk samples. The result depended not only on the radon emanation fraction, but also on the Ra-226 activity and the mineral content. Furthermore, using the obtained data, we also discussed the effect of grain size on radon emanation and why this has been reported to vary markedly in previous studies. (C) 2010 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.apradiso.2009.12.036

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  • Experimental and modeling studies of grain size and moisture content effects on radon emanation 査読

    Akihiro Sakoda, Yuu Ishimori, Katsumi Hanamoto, Takahiro Kataoka, Atsushi Kawabe, Kiyonori Yamaoka

    Radiation Measurements   45 ( 2 )   204 - 210   2010年2月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    Some models have already been developed to explain the effect of moisture content on the radon emanation fraction of soil. For this purpose, "microscopic" soil models, which are easy to deal with mathematically but cannot take grain size into consideration, have been designed. These previous models consist basically of two opposite grain surfaces and pores between the grains. In the present study, in order to study the effect of not only moisture content but also grain size, we present a simple modeling approach based on two "macroscopic" soil models: (1) a single-grain model and (2) a multiple-grain model. The latter model represents a configuration of spherical grains packed in a simple cubic structure. Based on these soil models and general assumptions, the radon emanation fraction was calculated as a function of grain size or moisture content by Monte Carlo simulation. The results for the multiple-grain model show that the radon emanation fraction is markedly increased with grain sizes ranging from 10 to 100 inn and reaches a constant value of 50% when moisture content is 0% and the radium is uniformly distributed on the grain surface. Moreover, a drastic increase is seen at smaller grain sizes with increasing moisture content. From these results, we concluded that the calculation of radon emanation depends greatly on the pore size between a Ra-bearing grain and a neighboring grain. The validity of the model was also evaluated by comparison to experimental data. (C) 2010 Elsevier Ltd. All rights reserved.

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  • Basic Study on Active Changes in Biological Function of Mouse Liver Graft in Cold Storage after Low-Dose X-Irradiation 査読

    Takahiro Kataoka, Masaaki Yoshimoto, Shinya Nakagawa, Yuko Mizuguchi, Takehito Taguchi, Kiyonori Yamaoka

    Journal of Clinical Biochemistry and Nutrition   45 ( 2 )   219 - 226   2009年9月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION  

    We previously reported that low-dose X-irradiation alleviates ischemia-reperfusion injury such as mouse paw edema. In this study, we examined active changes in the biological function of mouse liver grafts in cold storage after low-dose X-irradiation. Mouse livers were sham-irradiated or were irradiated with 0.25, 0.5, 1.0, or 5.0 Gy of X-ray and stored for 4, 8, 24, or 48 h in preservation or saline solution. The results show that storage for 24 h in saline solution after 0.5 Gy irradiation significantly increased the activity of superoxide dismutase (SOD) and catalase. Following storage for 4, 8, or 48 h in preservation solution, lipid peroxide levels of the 0.5 Gy irradiated group were significantly lower than those of the sham irradiated group. Following storage for 24 h in preservation solution, the activity of SOD and catalase of the 1.0 Gy irradiated group were significantly higher than those of the sham irradiated group. Hepatocytes stored in saline solution were vacuolated. However, no vacuole formation was observed in hepatocytes stored in preservation solution. These findings suggest that low-dose irradiation significantly activates antioxidative functions of liver grafts. Moreover, the dose at which enhancement of antioxidative function occurs in livers stored in preservation solution, which contains glutathione, is significantly higher than that in saline solution.

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  • No different sensitivity in terms of whole-body irradiation between normal and acatalasemic mice 査読

    Shinya Nakagawa, Takahiro Kataoka, Yuko Mizuguchi, Masaaki Yoshimoto, Akihiro Sakoda, Takaharu Nomura, Da-Hong Wang, Atsushi Kawabe, Takehito Taguchi, Kiyonori Yamaoka

    Journal of Clinical Biochemistry and Nutrition   43 ( 1 )   41 - 49   2008年7月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION  

    To elucidate the radiosensitivity of an acatalasemic mouse, we examined the time and dose-dependency in the survival rates, the lymphocytes and the intestinal epithelial cells, and the antioxidant function after 3.0 to 12.0 Gy whole body irradiation. Results showed that no significant differences between acatalasemic mice and normal mice were observed in the survival rates and the histological changes in spleens and small intestine after each irradiation. The catalase activities in livers and spleens of acatalasemic mice were significantly lower than those of normal mice and the glutathione peroxidase activity in livers of acatalasemic mice was significantly higher than that of normal mice. At 10 days after 6.0 Gy irradiation, the catalase activities in livers of acatalasemic and normal mice and that in spleens of normal mice significantly decreased compared with no-irradiation control, and there were no differences between those catalase activities. The total glutathione content in acatalasemic mice was significantly higher than that in normal mice at 10 days after 6.0 Gy irradiation. These findings suggested that the radiosensitivity of acatalasemic mice in terms of whole body irradiation doesn't significantly differ from that of normal mice, probably due to compensated sufficient contents of glutathione peroxidase and total glutathione in acatalasemic mice.

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  • Radioactivity and radon emanation fraction of the granites sampled at Misasa and Badgastein 査読 国際誌

    Akihiro Sakoda, Katsumi Hanamoto, Yuu Ishimori, Tomohiro Nagamatsu, Kiyonori Yamaoka

    Applied Radiation and Isotopes   66 ( 5 )   648 - 652   2008年5月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    The chemical composition was analyzed and the radioactivity, radon exhalation rate and emanation fraction were measured to investigate the characteristics of the granites sampled at Misasa and Badgastein, world famous for radon therapy. The Misasa granite was probably composed of quartz, albite and microcline. The Badgastein granite was probably composed of quartz and muscovite. The radon exhalation rates and emanation fractions of the Misasa granite were much higher than those of the Badgastein granite, regardless of the (226)Ra activity concentrations. (C) 2007 Elsevier Ltd. All rights reserved.

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  • Effects of some physical conditions on leaching rate of radon from radioactive minerals originating from some hot springs 査読

    Akihiro Sakoda, Katsumi Hanamoto, Yuu Ishimori, Tomohiro Nagamatsu, Kiyonori Yamaoka

    Radiation Measurements   43 ( 1 )   106 - 110   2008年1月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    In order to determine the best physical conditions for leaching more radon from minerals into water, we measured the leaching rate of radon from radioactive minerals under the conditions of some different grain sizes and water temperatures. Water temperature affected the leaching rate of radon although the grain size did not significantly affect it. Furthermore, we proposed ultrasonic irradiation to the mixture of a mineral and water as the method of leaching more radon. Ultrasonic irradiation was efficient to leach more radon from the mineral soaked in water because of ultrasonic cavitation. (C) 2007 Elsevier Ltd. All rights reserved.

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  • Inhibitory effects of prior low-dose X-irradiation on ischemia-reperfusion injury in mouse paw 査読 国際誌

    Takahiro Kataoka, Yuko Mizuguchi, Masaaki Yoshimoto, Takehito Taguchi, Kiyonori Yamaoka

    Journal of Radiation Research   48 ( 6 )   505 - 513   2007年11月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OXFORD UNIV PRESS  

    We have reported that low-dose, unlike high-dose, irradiation enhanced antioxidation function and reduced oxidative damage. On the other hand, ischemia-reperfusion injury is induced by reactive oxygen species. In this study, we examined the inhibitory effects of prior low-dose X-irradiation on ischemia-reperfusion injury in mouse paw. BALB/c mice were irradiated by sham or 0.5 Gy of X-ray. At 4 hrs after irradiation, the left hind leg was bound 10 times with a rubber ring for 0.5, 1, or 2 hrs and the paw thickness was measured. Results show that the paw swelling thickness by ischemia for 0.5 hr was lower than that for 2 hrs. At I hr after reperfusion from ischemia for I hr, superoxide dismutase activity in serum was increased in those mice which received 0.5 Gy irradiation and in the case of the ischemia for 0.5 or I hr, the paw swelling thicknesses were inhibited by 0.5 Gy irradiation. In addition, interstitial edema in those mice which received 0.5 Gy irradiation was less than that in the mice which underwent by sham irradiation. These findings suggest that the ischemia-reperfusion injury is inhibited by the enhancement of antioxidation function by 0.5 Gy irradiation.

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  • A comparative study on the characteristics of radioactivities and negative air ions originating from the minerals in some radon hot springs 査読 国際誌

    Akihiro Sakoda, Katsumi Hanamoto, Naoto Haruki, Tomohiro Nagamatsu, Kiyonori Yamaoka

    Applied Radiation and Isotopes   65 ( 1 )   50 - 56   2007年1月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    To elucidate the characteristics of some radon hot springs, we simulated a hot spring by soaking the rocks for the radon therapy in water and measured the concentrations of radon and negative air ions in various conditions. In the results, the individual rock structure could contribute to radon leaching because the radon leaching rates were independent of the grain sizes. More negative air ions were generated by the wet rocks than by the dry rocks. (c) 2006 Elsevier Ltd. All rights reserved.

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  • Activation of antioxidant system by low dose radiation and its applicable possibility for treatment of reactive oxygen species-related diseases 招待 査読

    Kiyonori Yamaoka

    Journal of Clinical Biochemistry and Nutrition   39 ( 3 )   114 - 133   2006年11月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION  

    We clarified that adequate oxygen stress induced by low dose irradiation activates not only chemical biological protective function, such as induction of the synthesis of superoxide dismutase, glutathione peroxidase, and heat shock protein 70, but also the biomembrane function, such as enhanced membrane fluidity and ATPase activity. It is possible that activation of these mechanisms alleviates in vivo oxidation injuries resulting in alleviation of pathologic condition, such as symptoms of hepatopathy and diabetes mellitus. Namely, adequate activation of the functions of the living body by low dose irradiation can contribute to suppressing aging and to preventing or reducing reactive oxygen species related diseases which are thought to involve peroxidation and have been regarded as the diseases for which radon spring water is an effective treatment. Clarification in detail of the mechanisms of these phenomena is required to understand the effects of low dose irradiation or radon inhalation on the functions of the living body, including adaptive response.

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  • Basic study on biochemical mechanism of thoron and thermal therapy 査読 国際誌

    Takahiro Kataoka, Yutaka Aoyama, Akihiro Sakoda, Shinya Nakagawa, Kiyonori Yamaoka

    Physiological Chemistry & Physics and Medical NMR   38 ( 2 )   85 - 92   2006年4月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Exposure to water in hot springs containing thoron is thought to exercise beneficial effects on hypertension and diabetes mellitus. To put to a test this hypothesis we examined the time dependent changes in the levels of lipid peroxide, vasoactive- and diabetes associated substances in human blood in order to throw further light on the possible beneficial influence of thoron and thermal therapy on the mechanism of hypertension and diabetes mellitus. Every 2 days, nasal inhalation of vapor containing thoron was performed for 40 min. Blood samples were collected after each treatment at 1,2, and 3 weeks after the first treatment. Results show that the treatment decreased the lipid peroxide levels. The finding suggests that the treatment contributes to the prevention of peroxidation reaction related to hypertension and diabetes mellitus. Moreover, the changes in vasoactive-associated substances indicate an increase in tissue perfusion, suggesting that the treatment plays a role in alleviating hypertension. The treatment decreased the total ketone body levels and the finding suggests that the treatment contributes to the prevention of diabetes mellitus related to the insulin deficiency.

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  • Histological changes in spleens of radio-sensitive and radio-resistant mice exposed to low-dose X-ray irradiation 査読 国際誌

    Takahiro Kataoka, Yuko Mizuguchi, Kenji Notohara, Takehito Taguchi, Kiyonori Yamaoka

    Physiological Chemistry & Physics and Medical NMR   38 ( 1 )   21 - 29   2006年2月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We have previously determined by using immune-assay or bio-assay methods that low-dose irradiation enhances immune and anti-oxidation functions. In this study, we examined histological changes of lymphatic follicles at 4, 24, or 48 hrs after sham, 0.25, 0.5, or 15 Gy irradiation in the spleens of BALB/c mice, which are sensitive to radiation compared with other strains, and C57BL/6J mice, which are resistant to radiation, using hematoxylin-eosin staining for lymphatic follicles or methylgreen pyronin staining for plasma cells. Results show that the lymphatic follicles in the spleens of the two mouse strains decreased at 24 or 48 hrs after 15 Gy irradiation. The number of plasma cells in the spleens of sham irradiated BALB/c mice was greater than that of sham irradiated C57BL/6J mice. At 4 hrs after 0.25 Gy irradiation, plasma cells increased in the spleens of the two mouse strains. These findings suggest, by histology, that low-dose irradiation activates the plasma cells and enhances the immune function. Although those two mouse strains have different sensitivities to radiation, the above changes were similar in both time course and degree of response. Therefore, the phenomena observed may be common in mice.

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  • Effects of post low-dose X-ray irradiation on carbon tetrachloride-induced acatalasemic mice liver damage 査読 国際誌

    Takahiro Kataoka, Takaharu Nomura, Da-Hong Wang, Takehito Taguchi, Kiyonori Yamaoka

    Physiological Chemistry & Physics and Medical NMR   37 ( 2 )   109 - 126   2005年4月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The catalase activities in the blood and organs of the acatalasemic (C3H/AnLCsb-Csb) mouse of the C3H strain are lower than those of the normal (C3H/AnLCsa-Csa) mouse. We examined the effects of post low-dose (0.5 Gy) X-ray irradiation which reduced the oxidative damage under carbon tetrachloride-induced hepatopathy in acatalasemic or normal mice. As a result, the 0.5 Gy irradiation after carbon tetrachloride administration decreased the glutamic oxaloacetic and glutamic pyruvic transaminase activity in the acatalasemic mouse blood to a level similar to that of the acatalasemic mouse blood not treated with carbon tetrachloride
    this is in contrast to a high-dose (15 Gy) irradiation. In the same manner, pathological disorder was improved by 0.5 Gy irradiation. The fat degeneration in normal mice was quickly reduced, in contrast to acatalasemic mice. These findings suggest that low-dose irradiation after carbon tetrachloride administration accelerates the rate of recovery and that catalase plays an important role in the recovery from hepatopathy induced by carbon tetrachloride, in contrast to high-dose irradiation.

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  • A comparative study on radioactive characteristics of the minerals for radon therapy 査読

    K Hanamoto, K Yamaoka

    Radiation Measurements   39 ( 2 )   157 - 160   2005年2月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    To elucidate the mechanism of the radon therapy, we analyzed the radioactive characteristics of the minerals in the famous regions for the radon therapy. Using a high-purity germanium detector, we measured the sludge at the hot bathroom with a high concentration of radon at Misasa Medical Center of Okayama University Medical School, the hokutolite, which was the same kind of mineral at Tamagawa Hot Spring in Japan, and the mineral at the gallery of Badgastein in Austria, which are celebrated regions for the radon therapy. As a result, the ratios of the uranium series to the thorium series for the sludge of Misasa, the hokutolite, and the mineral of Badgastein were 22, 50, and 0.94, respectively. The sludge of Misasa and the hokutolite mainly included the radioelements of the uranium series, while the mineral of Badgastein included the radioelements of both series with almost the same ratio. The ratio of the mineral of Badgastein is similar to that of background (1.1). Furthermore, two kinds of minerals, which are commercially available for radon therapy, were measured using the same detector. The ratios for the two minerals were 0.26 and 0.20, namely, the two minerals included larger radioelements of the thorium series than those of the uranium series. (C) 2004 Elsevier Ltd. All rights reserved.

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  • The elevation of p53 protein level and SOD activity in the resident blood of the Misasa radon hot spring district 査読 国際誌

    K Yamaoka, F Mitsunobu, S Kojima, M Shibakura, T Kataoka, K Hanamoto, Y Tanizaki

    Journal of Radiation Research   46 ( 1 )   21 - 24   2005年1月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN RADIATION RESEARCH SOC  

    To clarify the mechanism by which radon hot springs prevent cancer or not, in this study, blood was collected from residents in the Misasa hot spring district and in a control district. The level of a representative cancer-suppressive gene, p53, and the activity of a representative antioxidant enzyme, superoxide dismutase (SOD), were analyzed as indices. The level of serum p53 protein in the males in the Misasa hot spring district was found to be 2-fold higher than that in the control district, which is a significant difference. In the females in the Misasa hot spring district, SOD activity was approximately 15% higher than that in the control district, which is also statistically significant, and exceeded the reference range of SOD activity despite advanced age. These results suggested that routine exposure of the residents in the Misasa hot spring district to radon at a concentration about 3 times higher than the national mean induces trace active oxygen in vivo, potentiating products of cancer- suppressive gene and antioxidant function. As the p53 protein level was high in the residents in the Misasa hot spring district, apoptosis of cancer cells may readily occur.

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  • Study on biological effects of radon and thermal therapy on osteoarthritis 査読 国際誌

    K Yamaoka, F Mitsunobu, K Hanamoto, S Mori, Y Tanizaki, K Sugita

    Journal of Pain   5 ( 1 )   20 - 25   2004年2月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:CHURCHILL LIVINGSTONE  

    Radon therapy uses radon (Rn-222) gas, which mainly emits alpha-rays and induces a small amount of active oxygen in the body. We first examined the temporal changes in antioxidants, immune, vasoactive, and pain-associated substances in human blood by therapy to elucidate the mechanism of osteoarthritis in which radon therapy is used as a treatment. Results showed that radon inhalation enhanced the antioxidation and immune function, and the findings suggest that radon therapy contributes to the prevention of osteoarthritis related to peroxidation reactions and immune depression. Moreover, the changes in vasoactive and pain-associated substances indicated increases in tissue perfusion brought about by radon therapy, suggesting that radon inhalation plays a role in alleviating pain.
    Perspective: The findings suggest that an appropriate amount of active oxygen is produced in the body after radon inhalation, and this contributes to the alleviation of the symptoms of active oxygen diseases such as osteoarthritis. (C) 2004 by the American Pain Society.

    DOI: 10.1016/j.jpain.2003.09.005

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  • Biochemical comparison between radon effects and thermal effects on humans in radon hot spring therapy 査読 国際誌

    K Yamaoka, F Mitsunobu, K Hanamoto, K Shibuya, S Mori, Y Tanizaki, K Sugita

    Journal of Radiation Research   45 ( 1 )   83 - 88   2004年1月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN RADIATION RESEARCH SOC  

    The radioactive and thermal effects of radon hot spring were biochemically compared under a sauna room or hot spring conditions with a similar chemical component, using the parameters that are closely involved in the clinic for radon therapy. The results showed that the radon and thermal therapy enhanced the antioxidation functions, such as the activities of superoxide dismutase (SOD) and catalase, which inhibit lipid peroxidation and total cholesterol produced in the body. Moreover the therapy enhanced concanavalin A (ConA)-induced mitogen response and increased the percentage of CD4 positive cells, which is the marker of helper T cells, and decreased the percentage of CD8 positive cells, which is the common marker of killer T cells and suppressor T cells, in the white blood cell differentiation antigen (CD8/CD4) assay. Furthermore, the therapy increased the levels of a atrial natriuretic polypeptide (alphaANP), beta endorphin, adrenocorticotropic hormone (ACTH), insulin and glucose-6-phosphate dehydrogenase (G-6-PDH), and it decreased the vasopression level. The results were on the whole larger in the radon group than in the thermal group. The findings suggest that radon therapy contributes more to the prevention of life-style-related diseases related to peroxidation reactions and immune suppression than to thermal therapy. Moreover, these indicate what may be a part of the mechanism for the alleviation of hypertension, osteoarthritis (pain), and diabetes mellitus brought about more by radon therapy than by thermal therapy.

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  • Inhibitory effects of prior low-dose X-ray irradiation on carbon tetrachloride-induced hepatopathy in acatalasemic mice 査読 国際誌

    K Yamaoka, T Kataoka, T Nomura, T Taguchi, DH Wang, S Mori, K Hanamoto, S Kira

    Journal of Radiation Research   45 ( 1 )   89 - 95   2004年1月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN RADIATION RESEARCH SOC  

    The catalase activities in blood and organs of the acatalasemic (C3H/AnLCs(b)Cs(b)) mouse of C3H strain are lower than those of the normal (C3H/AnLCs(a)Cs(a)) mouse. We examined the effects of prior low-dose (0.5 Gy) X-ray irradiation, which reduced the oxidative damage under carbon tetrachloride-induced hepatopathy in the acatalasemic or normal mice. The acatalasemic mice showed a significantly lower catalase activity and a significantly higher glutathione peroxidase activity compared with those in the normal mice. Moreover, low-dose irradiation increased the catalase activity in the acatalasemic mouse liver to a level similar to that of the normal mouse liver. Pathological examinations and analyses of blood glutamic oxaloacetic and glutamic pyruvic transaminase activity and lipid peroxide levels showed that carbon tetrachloride induced hepatopathy was inhibited by low-dose irradiation. These findings may indicate that the free radical reaction induced by the lack of catalase and the administration of carbon tetrachloride is more properly neutralized by high glutathione peroxidase activity and low-dose irradiation in the acatalasemic mouse liver.

    DOI: 10.1269/jrr.45.89

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  • 展望 ラドン療法の適応症とその機構解明の現状 招待 査読

    山岡聖典

    Isotope News   588   2 - 8   2003年4月

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    担当区分:責任著者   掲載種別:研究論文(学術雑誌)  

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  • Elevation of antioxidant potency in mice brain by low-dose X-ray irradiation and its effect on Fe-NTA-induced brain damage 査読 国際誌

    Kiyonori Yamaoka, Shuji Mori, Takaharu Nomura, Takehito Taguchi, Takehiko Ito, Katsumi Hanamoto, Shuji Kojima

    Physiological Chemistry & Physics and Medical NMR   34 ( 2 )   119 - 132   2002年4月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The increase in lipid peroxide levels in mice brain following Fe 3+ administration was about 50% of that when 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine (MPTP) was administered. This may be due to excessive oxidation by Fe3+, and was supported by the decrease in activities of antioxidant enzymes, such as superoxide dismutase (SOD), catalase and glutathione peroxidase (GPX), Na+,K+-ATPase activity and membrane fluidity after Fe3+ administration. Relatively low-dose X-ray irradiation (0.5 Gy) inhibited lipid peroxidation associated with Fe 3+ administration and restored the decreased activities of the above antioxidant enzymes and Na+K+-ATPase, and membrane fluidity to the levels in the non-Fe3+-administered group. In the purine metabolism system, uric acid decreased after Fe3+ administration, which may be due to transient impairment of the system for production of uric acid from xanthine by excessive oxidation by Fe3+. However, 0.5 Gy irradiation inhibited this decrease in uric acid, increasing its level to that in the non Fe3+-administrated group. This may be due to factors such as rapid recovery of the activities of the above antioxidant enzymes and Na+,K+-ATPase, and membrane fluidity after 0.5 Gy irradiation. In addition, since no changes were observed in xanthine and uric acid, increased inosine and hypoxanthine may have advanced to a salvage pathway leading to not xanthine but inosine 5′-monophosphate (IMP).

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  • Adjustment function among antioxidant substances in acatalasemic mouse brain and its enhancement by low-dose x-ray irradiation 査読 国際誌

    Kiyonori Yamaoka, Takaharu Nomura, Da-Hong Wang, Shuji Mori, Takehito Taguchi, Tetsuya Ishikawa, Katsumi Hanamoto, Shohei Kira

    Physiological Chemistry & Physics and Medical NMR   34 ( 2 )   133 - 144   2002年4月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The catalase activities in blood and organs of the acatalasemic (C3H/AnLCsbCsb) mouse of the C3H strain are lower than those of the normal (C3H/AnLCsaCsa) mouse. We conducted a study to examine changes in the activities of antioxidant enzymes, such as catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPX), the total glutathione content, and the lipid peroxide level in the brain, which is more sensitive to oxidative stress than other organs, at 3, 6, or 24 hr following X-ray irradiation at doses of 0.25, 0.5, or 5.0 Gy to the acatalasemic and the normal mice. No significant change in the lipid peroxide level in the acatalasemic mouse brain was seen under non-irradiation conditions. However, the acatalasemic mouse brain was more damaged than the normal mouse brain by excessive oxygen stress, such as a high-dose (5.0 Gy) X-ray. On the other hand, we found that, unlike 5.0 Gy X-ray, a relatively low-dose (0.5 Gy) irradiation specifically increased the activities of both catalase and GPX in the acatalasemic mouse brain making the activities closer to those in the normal mouse brain. These findings may indicate that the free radical reaction induced by the lack of catalase is more properly neutralized by low dose irradiation.

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  • Elevation of Glutathione Induced by Low-dose γ-rays and its Involvement in Increased Natural Killer Activity 査読 国際誌

    S.Kojima, Hirokazu Ishida, M.Takahashi, K.Yamaoka

    Radiation Research   157 ( 3 )   275 - 280   2002年3月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1667/0033-7587(2002)157[0275:EOGIBL]2.0.CO;2

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  • Basic Study on Radon Effects and Thermal Effects on Humans in Radon Therapy 査読

    Kiyonori Yamaoka, Takashi Mifune, Fumihiro Mitsunobu, Shuji Kojima, Shuji Mori, Koichi Shibuya, Yoshiro Tanizaki, Katsuhiko Sugita

    Physiological Chemistry & Physics and Medical NMR   33 ( 2 )   133 - 138   2001年4月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Because most of the diseases to which radon (222Rn) therapy is applied are related to activated oxygen, in this study the effect of the radioactivity of radon and the thermal effect were compared under a room or a hot spring condition with the same chemical component using as the parameters the activity of superoxide dismutase (SOD), which is an oxidation inhibitor, and lipid peroxide and low density lipoprotein (LDL)-cholesterol, which are closely involved in arteriosclerosis. Results show that the SOD activity was significantly increased, and the lipid peroxide and LDL-cholesterol levels were significantly decreased on days 6 and 7 of study. The results were about 2-fold larger in the radon group than in the thermo group. This suggests that the anti-oxidation function was more enhanced by radon therapy than by thermo therapy, and suggests that radon therapy may help to prevent the causes of life style-related diseases such as arteriosclerosis. These findings are important in understanding the mechanism of diseases in which radon therapy is used as treatment, and most of which are called activated oxygen-related diseases.

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  • Possible role of elevation of glutathione in the acquisition of enhanced proliferation of mouse splenocytes exposed to small-dose gamma-rays 査読

    Kojima Shuji, Shiramine Matsumori, Hideki Ishida, Kiyonori Yamaoka

    International Journal of Radiation Biology   76 ( 12 )   1641 - 1647   2000年12月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:TAYLOR & FRANCIS LTD  

    Purpose: To examine the relation between the induction of an increased glutathione level and the elevated proliferative response of mouse splenocytes by a small dose of gamma -rays.
    Materials and methods: Male ICR strain mice, 7 weeks of age, were divided into irradiated and non-irradiated control groups. irradiation was done with gamma -rays from a Cs-137 source at a dose of 50 cGy (1.11 Gy/min). Glutathione content in the splenocytes was measured using a modified spectrophotometric technique. Concanavalin A (Con A)-induced proliferative response of the splenocytes after whole-body gamma -ray irradiation was estimated from the H-3-thymidine incorporation into the cells.
    Results: The glutathione level in mouse splenocytes increased 2 h after whole-body gamma -ray irradiation at 50 cGy, peaked at 4-h and thereafter decreased almost to the zero-time level by 12-h postirradiation. A significant enhancement of Con A-induced proliferation was observed in the splenocytes obtained from the whole-body-irradiated animals between 2 h and 6 h post-irradiation. Glutathione exogenously added to splenocytes obtained from normal mice enhanced the Con A-induced proliferation of splenocytes in a dose-dependent manner. This enhancement was completely blocked by buthionine sulfoximine, a specific inhibitor of the de novo pathway of glutathione synthesis.
    Conclusions: The induction of endogenous glutathione immediately after low-dose gamma -ray irradiation is at least partially responsible for the enhancement of immune function, and may throw light on the mechanisms of carcinostatic effects induced by low dose ionizing radiation.

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  • Mechanisms involved in the elevation of glutathione in RAW 264.7 cells exposed to low doses of gamma-rays 査読

    Kojima Shuji, Kazuo Teshima, Kiyonori Yamaoka

    Anticancer Research   20 ( 3A )   1589 - 1594   2000年5月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:INT INST ANTICANCER RESEARCH  

    We examined the mechanisms of the elevation of glutathione level induced in macrophage-like RAW 264.7 cells by low closes of gamma-rays. The level increased soon after exposure of the cells to 50 cGy of gamma-rays, peaked between 3 hours and 6 hours and rearmed almost to the time 0 value by 24 hours post-irradiation. Doses between 25 and 100 cGy significantly increased the glutathione level at 4 hours post-irradiation. However there was no significant elevation at doses of more than 100 cGy or less than 25 cGy. When the effect of dose I-ate was examined at a constant absorbed dose of 50 cGy, dose rates Of more than 50 cGy/minute significantly increased the GSH level at 4 hours post-irradiation. It was also shown that the elevation of glutathione level in cells irradiated with low doses of gamma-rays followed the induction of mRNA coding for gamma-glutamylcysteine synthetase (gamma-GCS) a rate-limiting enzyme of the de novo glutathione synthesis pathway When the cells were exposed to the radiation in the presence of genistein, calphostin C or nifedipine, the elevations of glutathione and gamma-GCS mRNA expression were both mostly blocked. EGTA also strongly inhibited these elevations. These results suggest that the tyrosine kinase, calcium channel and protein kinase C activities play an essential role in the law-dose-radiation-induced elevation of cellular glutathione.

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  • Inhibitory Effects of Post Low Dose γ-ray Irradiation on Ferric-nitrilotriacetate-induced Mice Liver Damage 査読

    Kiyonori Yamaoka, Shuji Kojima, Takaharu Nomura

    Free Radical Research   32 ( 3 )   213 - 221   2000年3月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Low-dose γ-ray Irradiation Reduces Oxidative Damage in Mouse Liver Induced by CCl4 査読

    Takaharu Nomura, Kiyonori Yamaoka

    Free Radical Biology & Medicine   27 ( 11-12 )   1324 - 1333   1999年12月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    We examined the effects of irradiation (50 cGy of gamma-ray) reducing the oxidative damage in carbon tetrachloride (CCl4)-hepatopathy mice. We made pathological examinations and analyzed transaminase activity (glutamic oxaloacetic transaminase and glutamic pyruvic transaminase), lipid peroxide level and the activities of endogenous antioxidants in the mouse. The irradiation was found to accelerate the recovery. Based on pathological examination as well as changes in each transaminase activity and lipid peroxide levels, it was shown that hepatopathy improved 3 d after the irradiation. The activities of glutathione reductase and glutathione peroxidase rapidly elevated after irradiation, and the total glutathione content gradually increased in the irradiation group. Both activities of gamma-glutamylcysteine synthetase and catalase were higher than normal at all times after the irradiation and gradually increased. In addition, the gamma-glutamylcysteine synthetase activity changed In a similar fashion to the total glutathione content. However, superoxide dismutase activity in bath groups decreased and that of the irradiation group was significantly lower than that of the sham-irradiation group. These findings suggest that low-dose radiation relieved functional disorder at least in the liver of mice with active oxygen diseases. (C) 1999 Elsevier Science Inc.

    DOI: 10.1016/S0891-5849(99)00180-X

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  • Elevation of glutathione in RAW 264.7 cells by low-dose gamma-ray irradiation and its responsibility for the appearance of radioresistance 査読

    Shuji Kojima, Shirane Matsumori, Hideki Ono, Kiyonori Yamaoka

    Anticancer Research   19 ( 6B )   5271 - 5275   1999年11月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:INT INST ANTICANCER RESEARCH  

    We examined the relationship between the induction of glutathione (GSH) level in macrophage-like RAW 264.7 cells by a low (adapting) dose gamma-rays and the cell damage caused by a lethal dose of gamma-rays at var-lolls intervals after the adapting dose. The reduced glutathione (GSH) level increased soon after exposure of the cells to 25 cGy of gamma-rays, peaked between 3 hl and 6 hr, and returned almost to the zero time (0 hr) bevel by 24 hr post-irradiation Cell damage was assessed by measuring the H-thymidine (H-3-TdR) incorporation into cellular DNA. gamma-Ray irradiation produced a dose- dependent cell damage in RAW cells, causing about 40% and 60% inhibition of H-3-TdR incorporation into DNA at 1.0 Gy and 2.0 Gy, respectively, as compared with non-irradiated cells. Treatment with the adapting dose of 25 cGy at I hr or 24 hr before the lethal irradiation was ineffective. However, pre-irradiation with 25 cGy at 3 hr or 6 hr prior to lethal irradiation inhibited the decrease of H-3-TdR incorporation into DNA, indicating a protective effect. GSH exogenously added to the medium also inhibited the cell damage induced by lethal doses of gamma-Rays in a dose-dependent manner. These results indicate that the induction of endogenous GSH in living cells immediately following low-dose gamma-Ray irradiation is at least partially responsible for the appearance of radioresistance to a subsequent lethal dose of radiation, and may make it possible to use higher doses of radiation in radiotherapy for tumor patients.

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  • Changes of SOD-like Substances in Mouse Organs after Low-dose X-ray Irradiation 査読

    Kiyonori Yamaoka, Shuji Kojima, Takahara Nomura

    Physiological Chemistry & Physics and Medical NMR   31 ( 1 )   23 - 28   1999年2月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We demonstrated that low-dose irradiation with 50 cGy of X-ray induces in vivo production of superoxide dismutase (SOD)-like substances and accelerates antioxidant activity. To elucidate the defense mechanism against X-ray radiation, we examined which components among these SOD-like substances, such as SOD, vitamin C and celuroplasmin, are produced by low-dose irradiation. Our study revealed that SOD-like specific activity hardly involved SOD-like substances other than SOD. Moreover, it is suggested that low-dose irradiation induced synthesis and production of SOD itself, leading to elevation of SOD-specific activity.

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  • Induction of mRNAs for glutathione synthesis-related proteins in mouse liver by low doses of gamma-rays 査読

    S Kojima, O Matsuki, T Nomura, A Kubodera, Y Honda, S Honda, H Tanooka, H Wakasugi, K Yamaoka

    Biochimica et Biophysica Acta   1381 ( 3 )   312 - 318   1998年8月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    We examined the elevation of the reduced form of glutathione (GSH) level and the induction of mRNAs for proteins involved in the synthesis and regeneration of GSH in the liver of mice after low-dose gamma-ray irradiation. The liver GSH level increased soon after irradiation with 50 cGy of gamma-rays, reached a maximum at around 12 h post-treatment, The mRNA of gamma-glutamylcysteine synthetase (gamma-GCS), the rate-limiting enzyme for de novo synthesis for GSH, showed a small increase that peaked at 6 h after gamma-ray irradiation at a dose of 50 cGy. Only a small increase in gamma-GCS activity was observed throughout the 24-h post-irradiation period. In the case of glutathione reductase (GR), which is involved in the regeneration of GSH from the oxidized form (GSSG), the mRNA level peaked strongly at 1 h, while the activity peaked at twice the control level 12 h after irradiation. The level of mRNA for thioredoxin (TRX), which contributes to GSH biosynthesis by supplying cysteine to the de novo pathway, peaked at 1 h and declined thereafter, while the activity peaked at 3 h and then declined sharply. These results indicate that the increase in endogenous GSH immediately following low-dose gamma-ray irradiation is predominantly due to operation of the regeneration cycle and not de novo synthesis. We also examined the dependence of mRNA induction on the gamma-ray dose. (C) 1998 Elsevier Science B.V. All rights reserved.

    DOI: 10.1016/S0304-4165(98)00043-9

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  • Change of glutathione peroxidase synthesis along with that of superoxide dismutase synthesis in mice spleens after low-dose X-ray irradiation 査読

    K Yamaoka, S Kojima, M Takahashi, T Nomura, K Iriyama

    Biochimica et Biophysica Acta   1381 ( 2 )   265 - 270   1998年7月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    We have previously demonstrated that the activity of superoxide dismutase (SOD), an antioxidant, is enhanced by low-dose X-ray irradiation in various organs of animals such as rats. Since SOD is an enzyme that mediates the dismutation of O-2(-) to H2O2, the question as to whether the resultant H2O2 is further detoxicated into H2O and O-2 or not must still be evaluated. Hence, we studied the effect of low-dose X-ray irradiation on the synthesis of glutathione peroxidase (GSHPx), which is an antioxidant that catalyzes this reaction. The results suggest that H2O2 produced by increased SOD activity can be detoxicated into H2O and O-2 due to simultaneous enhancement of the GSHPx activity by X-ray irradiation at 20 cGy, in contrast to irradiation at 400 cGy. The results also show the enhancement in enzyme activities by induction of their synthesis shortly after irradiation at 20 cGy, Moreover, as this phenomenon was observed in BALB/c mice (which are more radiation-sensitive compared to other mouse strains) and radiation-resistant C57BL/6NJcl mice, it was considered to be a common phenomenon in the rat spleen. (C) 1998 Elsevier Science B.V. All rights reserved.

    DOI: 10.1016/S0304-4165(98)00021-X

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  • Elevation of mouse liver glutathione level by low-dose gamma-ray irradiation and its effect on CCl4-induced liver damage 査読

    S Kojima, O Matsuki, T Nomura, A Kubodera, K Yamaoka

    Anticancer Research   18 ( 4A )   2471 - 2476   1998年7月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:INT INST ANTICANCER RESEARCH  

    We examined the elevation of glutathione (GSH) levels in the liver of C57BL/6 female mice after low-dose r-ray irradiation and its inhibitory effect on CCl4-induced liver damage. The liver GSH level increased soon after irradiation with 50 cGy of gamma-rays, reached a maximum at around 12 post-treatment, and returned almost to the control level by 24 h. The activities of glutathione reductase, and glutathione peroxidase also showed the same pattern of change, while the activity of gamma-glutamylcysteine synthetase showed a gradual increase up to 24 h. The effect of pre-irradiation on CCl4-induced liver damage was also investigated. The activities of glutamic oxaloacetic transaminase and glutamic pyruvic transaminase in serum were markedly increased 12 h post-treatment with CCl4. Both increases were significantly suppressed by a single low-dose pre-irradiation. Malondialdehyde, a marker of lipidperoxidation, was also greatly elevated after CCl4 treatment, and its increase was suppressed by irradiation. These results suggest low-dose gamma-ray irradiation might be effective for the prevention of and/or therapy of various reactive oxygen species-related diseases including cancer.

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  • Inhibitory effects of prior low dose X-ray irradiation on Fe3+-NTA-induced hepatopathy in rats 査読

    K Yamaoka, T Nomura, K Iriyama, S Kojima

    Physiological Chemistry & Physics and Medical NMR   30 ( 1 )   15 - 23   1998年2月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PHYSIOL CHEM PHYSICS MED NMR  

    Blood activities of hepatocellular enzymes such as lactate dehydrogenase (LDH), glutamic pyruvic transaminase (GPT) and glutamic oxalacetic transaminase (GOT) peaked at 12 hours after a single intraabdominal injection of ferric nitrilotriacetate (Fe3+-NTA) in rats. Enzymes such as alkaline phosphatase (ALP) and leucin amino peptidase (LAP) originating in the capillary bile ducts or bile secretory liver cells were also released into the blood between 6-24 hours after intraabdominal injection of Fe3+-NTA in rats. Furthermore, hyperoxidation of lipids occurred in rat hepatic cell membranes, reaching a peak 6 hours after intraabdominal injection of Fe3+-NTA. It was found that a single prior 0.5 Gy whole body X-ray irradiation significantly increased superoxide dismutase (SOD) activities and suppressed above-mentioned symptoms of transient hepatopathy in rats.

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  • Simultaneous quantitative analysis of prostaglandins and thromboxane after low-dose X irradiation 査読

    K Yamaoka, T Obata, K Iriyama, T Iwasaki, Y Hoshi

    Radiation Research   149 ( 1 )   103 - 106   1998年1月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:RADIATION RESEARCH SOC  

    The appearance of prostaglandins and thromboxane in mouse serum after X irradiation was observed by simultaneous quantitative analysis using gas chromatography/mass spectrometry/selected ion monitoring with stable isotope dilution methods. Mice of two strains (C57BL/CN Jcl and BALB/c) showed similar responses to X irradiation. In C57BL/6N Jcl mice, 0.2 Gy irradiation elicited a significant increase in generation of prostanoids: Immediately after irradiation, the 6-keto PGF(1) alpha:TXB2 ratio and the level of PGE(2) increased, after 20 min 6-keto PGF(1) alpha and PGE(2) increased, and after 4 h PGE(1) and PGE(2) increased. In BALB/c mice, generation of prostanoids was increased significantly immediately after irradiation (6-keto PGF(1) alpha, 6-keto PGF(1) alpha:TXB2 ratio, PGE(2)), and the increase was maintained from 20 min to 4 h (PGE(1), PGE(2)) after 0.2 Gy irradiation. In C57BL/6N Jcl mice, a significant increase in production of 9 alpha,11 beta-PGF(2) was observed at 20 min after irradiation. In BALB/c mice, a significant increase in 9 alpha,11 beta-PGF(2) was seen immediately after irradiation and was maintained for 20 min. In C57BL/6N Jcl mice, the level of 8-epi PGF(2) alpha was clearly increased 4 h after 4 Gy irradiation. A slight and slow increase was also seen after 0.2 Gy irradiation. In BALB/c mice, 8-epi PGF(2) alpha was increased significantly at 20 min and 4 h after 4 Gy irradiation. These results show that 0.2 Gy irradiation stimulates production of prostanoids related to the inflammatory response in mice. (C) 1998 by Radiation Research Society.

    DOI: 10.2307/3579687

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  • 低線量放射線による化学的生体防御機構の活性化と生体内酸化傷害の緩和 招待 査読

    山岡聖典

    フリーラジカルの臨床   11   31 - 37   1997年6月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • Effects of Low Dose X-ray Irradiation on Purine Metabolism in Mouse Splenocytes 査読

    K.Yamaoka, E.Niki, M.Takahashi, K.Iriyama

    Physiological Chemistry & Physics and Medical NMR   29 ( 1 )   1 - 10   1997年2月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

    This study examines the influence of low dose X-ray irradiation on purine nucleotide metabolites such as adenosine, inosine, hypoxanthine, xanthine and uric acid, and hence generation of ATP-mediated energy in mouse splenocytes. It was found that, unlike high dose irradiation which promotes membrane damage, low dose irradiation enhances the ability to regulate the energy metabolisms as reflected by the increase in Na+, K+-ATPase activity and the adequate activation of the above salvage pathway. Namely, the levels of adenosine, inosine and uric acid significantly increased, while the levels of xanthine and hypoxanthine decreased significantly. Moreover, the cysteine level and Superoxide dismutase activity significantly increased at a dosage of 20 cGy.

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  • 生体防御機構 招待 査読

    山岡聖典

    放医研シンポジウムシリーズ   27   97 - 112   1996年9月

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    担当区分:責任著者   掲載種別:研究論文(学術雑誌)  

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  • Experimental Study of Alleviation of Hypertation, Diabetes and Pain by Radon Inhalation 査読

    K.Yamaoka, Y.Komoto

    Physiological Chemistry & Physics and Medical NMR   28 ( 1 )   1 - 5   1996年2月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

    Indications for treatment at the Misasa Hot Spring, a radon producing radioactive spring, include hypertension, diabetes mellitus and pain. To clarify its mechanisms of action on these conditions, we evaluated dynamic changes in blood components such as vasoactive substances after radon inhalation. Vasodilation, alleviation of diabetic symptoms and morphine-like analgesic effects were observed, suggesting that these changes constitute part of the mechanisms of the radon spring therapy on the above conditions.

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  • 少量活性酸素による化学的生体防御機構の活性化と生体内酸化傷害の緩和に関する研究(Study on the Activation of Chemical Biological Defense Mechanism and the Alleviation of in vivo Oxidative Damage by Small Amounts of Active Oxygen) 査読

    山岡聖典

    早稲田大学博士論文(理学)   1 - 115   1996年2月

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    担当区分:責任著者   記述言語:英語   掲載種別:学位論文(博士)  

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  • 生理機能に及ぼす低線量放射線の作用に関する研究 招待 査読

    山岡聖典

    環境変異原研究 (日本環境変異原学会誌)   16 ( 3 )   333 - 344   1995年7月

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    担当区分:責任著者   掲載種別:研究論文(学術雑誌)  

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  • Effects of Low-Dose γ-irradiation to the Chest Regions on the Blood Pressure of Spontaneous Hypertensive Rat 査読

    K.Yamaoka, K.Ishii

    Physiological Chemistry & Physics and Medical NMR   27 ( 3 )   161 - 165   1995年6月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

    We examined changes in the blood pressure and the superoxide dismutase (SOD) activities in aortic tissue after gamma-irradiation to the chest regions of spontaneous hypertensive rats (SHR) and Wistar Kyoto rats (WKY), and obtained the following results. After 5 Gy irradiation, there was no change with time in the blood pressure in WKY rats, while a transient decrease (3 days later) was observed in SHR rats. The Cu/Zn-SOD activity in the aorta of SHR was less than that of WKY. 5 Gy irradiation induced an increase in the Cu/Zn-SOD activity in SHR nearly to the level observed in WKY, which remained unchanged upon irradiation. Therefore, unlike high-dose irradiation, irradiation at a relatively low-dose of 5 Gy to SHR appears to increase the aortic Cu/Zn-SOD activity, which is lacking in SHR, leading to a decrease in the blood pressure.

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  • Changes in Specific Amino Acid Residues and Na+,K+-ATPase Activity in Cell Membranes of Rat Cerebral Cortex by Low Dose X-irradiation 査読

    K.Yamaoka, K.Ishii, R.Edamatsu, T.Ito, A.Mori

    Physiological Chemistry & Physics and Medical NMR   26 ( 4 )   323 - 328   1994年8月

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    担当区分:筆頭著者   掲載種別:研究論文(学術雑誌)  

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  • Effects of Low Dose X-irradiation on Biomembrane in Brain Cortex of Aged Rats 査読

    K.Yamaoka, R.Edamatsu, T.Ito, A.Mori

    Free Radical Biology & Medicine   16 ( 4 )   529 - 534   1994年8月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Induction of Two Species of Superoxide Dismutase in Some Organs of Rats by Low Dose X-irradiation 査読

    K.Yamaoka, E.F.Sato, K.Utsumi

    Physiological Chemistry & Physicsand Medical NMR   26 ( 3 )   205 - 214   1994年6月

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    担当区分:筆頭著者   掲載種別:研究論文(学術雑誌)  

    Four hours after 0.25 Gy X-irradiation, the enzymatic activity of copper and zinc activated superoxide dismutase (Cu/Zn-SOD) in the spleen of mature rats showed a significant quantitative increase (by 25%); this was accompanied by a marked increase (by 70%) in the mRNA for this enzyme as compared to the control (sham irradiation) group. Irradiation had no effect on the enzymatic activity of manganese activated superoxide dismutase (Mn-SOD). Moreover, the expression of the mRNA for Mn-SOD was similar to that of the unirradiated control group. On the other hand, the enzymatic activity of both Cu/Zn-SOD and Mn-SOD in the liver of fetal rats showed a significant quantitative increase (by 15-35%); the expression of the mRNA for the two species of SOD increased (by 20-30%) at 4 hours after 1 Gy X-irradiation as compared to the control group. These findings suggest that the increase in SODmRNA level is due to novel transcription of SODmRNA by low dose irradiation.

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  • Study on Effects of Low Dose Radiation on Biological Function:1)Increased SOD Activities and Decreased Lipid Peroxides Levels Induced by low Dose X Irradiation in Rat Organs, 2)Effects of Low Dose X-ray Irradiation on Biomembrane in Brain Cortex of Aged Rats, and 3)Effects of Radon Inhalation on Biological Function-Lipid Peroxide, Superoxide Dismutase Activity and Membrane Fluidity 査読

    Kiyonori Yamaoka

    岡山大学博士論文(医学)(Okayama University Doctoral Thesis (Medicine))   1994年3月

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    担当区分:責任著者   記述言語:英語   掲載種別:学位論文(博士)  

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  • 低線量放射線が過酸化脂質量,SOD活性,および膜流動性に及ぼす影響ーラドン温泉の適応症および老化抑制との関連に着目してー 査読

    山岡聖典, 枝松礼, 古元嘉昭, 鈴鹿伊智雄, 森 昭胤

    磁気共鳴と医学   4   82 - 89   1993年5月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • Effects of Radon Inhalation on Biological Function-Lipid Peroxide, SOD Activity and Membrane Fluidity- 査読

    K.Yamaoka, Y.Komoto, I.Suzuka, R.Edamatsu, A.Mori

    Archives of Biochemistry and Biophysics   302 ( 1 )   37 - 41   1993年4月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS  

    We administered radon (Rn) to rabbits by inhalation and examined changes in the lipid peroxide (TBARS) level, superoxide dismutase (SOD) activity, and membrane fluidity in various organs to clarify the therapeutic effects of Rn. The lipid peroxide level of the brain was significantly decreased immediately after Rn inhalation for 90 min in both the low concentration group (about 7 ~ 10 kBq/liter) and the high concentration group (about 14 ~ 18 kBq/liter) as compared with that in the control group. It further decreased in the low concentration group but slightly recovered in the high concentration group 2 h after inhalation. The lipid peroxide level of the lung showed no change immediately after inhalation but decreased significantly in both groups 2 h after inhalation. With regard to SOD activity in the brain and lung, only that in the brain showed significant increase in the high concentration group immediately after inhalation; no other change was observed. Membrane fluidity, especially the fluidity of membrane protein, was significantly increased in the brains of both groups immediately after inhalation, and that 2 h after inhalation in the lung was significantly increased in both groups. These findings suggest that the inhalation of Rn at Rn springs contributes to the prevention of brain disorders related to peroxidation reactions by promoting these physiologic changes. © 1993 Academic Press, Inc.

    DOI: 10.1006/abbi.1993.1177

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  • Increased SOD Activities and Decreased Lipid Peroxides Levels in Rat Organs Induced by low Dose X-irradiation 査読

    K.Yamaoka, R.Edamatsu, A.Mori

    Free Radical Biology & Medicine   11 ( 3 )   299 - 306   1991年6月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    After a single exposure to doses ranging from 0.05 to 0.50 Gy, the SOD activities in immune organs of the irradiated rats, at 4 h after whole-body X irradiation, showed significant increases by 50 to 90% (hereinafter p &lt; 0.05) in comparison with the control groups. The dose in the brain and liver showed tendencies to increase by 30 to 50% for doses ranging from 0.50 to 2.50 Gy. The levels of TBARS (lipid peroxides) in immune organs decreased significantly by 20 to 50% in contrast with the control groups for doses ranging from 0.10 to 1.00 Gy. Decreases by 20 to 30% were observed in brains and livers for doses near 0.50 Gy. When the dose was 0.25 Gy, the SOD activities in the spleen showed a persistent radiation-induced increase for at least 12 weeks, livers for 8 weeks, brains and thymuses for 4 weeks, and bone marrows for about 1 week. The TBARS levels in the brain and thymus showed persistent decreases due to irradiation for at least 12 weeks, and those in bone marrows for 8 h.

    DOI: 10.1016/0891-5849(91)90127-O

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  • 総説 ラドン・トロンの健康効果に関する最近の研究動向 Ⅱ 招待 査読

    山岡聖典

    日本機能性イオン協会誌   33 ( 1 )   3 - 11   2024年1月

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    担当区分:責任著者   掲載種別:研究論文(大学,研究機関等紀要)  

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  • Effects of low-dose/high-dose-rate X-irradiation on oxidative stress in organs following forced swim test and its combined effects on alcohol-induced liver damage in mice 査読

    Shota Naoe, Yuki Fujimoto, Kaito Murakami, Ryohei Yukimine, Ayumi Tanaka, Kiyonori Yamaoka, Takahiro Kataoka

    Journal of Radiation Research   64 ( 4 )   635 - 643   2023年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Oxford University Press (OUP)  

    Abstract

    The liver’s susceptibility to oxidative stress after a combination of forced swim test (FST) and low-dose-rate γ-irradiation has been observed. Therefore, this study aims to clarify the effects of low-dose (0.1 and 0.5 Gy)/high-dose-rate (1.2 Gy/min) irradiation on combined oxidative stressors—liver damage associated with FST and alcohol administration. In addition, the effects of similar irradiation on FST-induced immobility, which induces psychomotor retardation, and antioxidative effects on the brain, lungs, liver and kidneys were investigated, and the results were compared with those of a similar previous study that utilized low-dose-rate irradiation. Low-dose/high-dose-rate (especially 0.5 Gy) irradiation temporarily worsened liver antioxidant function and hepatic function with FST- and alcohol administration-related oxidative damage; however, the damages improved soon after. In addition, the increase in total glutathione content in the liver contributed to the early improvement of hepatic functions. However, pre-irradiation did not suppress immobility during the FST. The results also suggested that the effects of low-dose/high-dose-rate irradiation on the antioxidant functions of each organ after the FST were different from those of low-dose/low-dose-rate irradiation. Overall, this study provides further insights into the effects of low-dose irradiation on exposure to a combination of different oxidative stressors. It will also contribute to the elucidation of dose rate effects on oxidative stress in the low-dose irradiation range.

    DOI: 10.1093/jrr/rrad030

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  • Changes in sulfur metabolism in mouse brains following radon inhalation 査読

    Norie Kanzaki, Akihiro Sakoda, Takahiro Kataoka, Lue Sun, Hiroshi Tanaka, Iwao Ohtsu, Kiyonori Yamaoka

    International Journal of Environmental Research and Public Health 19(17), 10750, 2022   19 ( 17 )   10750 - 10750   2022年8月

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    担当区分:最終著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:MDPI AG  

    Therapy using hot springs, including the high-level radioactive gas “radon”, is traditionally conducted as an alternative treatment for various diseases. Oxidative-stress-related diseases are inhibited by the enhancement of antioxidative functions following radon inhalation. We have reported that radon inhalation increased the level of anti-oxidants, such as glutathione (G-SH), in the brain and had a protective antioxidative effect against transient global cerebral ischemic injury. However, no studies have yet revealed the changes in G-SH associated substances after radon inhalation. In this study, we comprehensively analyzed several metabolites, focusing on G-SH. Mice were exposed to radon at concentrations of 200, 2000, or 20,000 Bq/m3 for 1, 3, or 10 days. We detected 27 metabolites in the mouse brains. The result showed that the L-methionine levels increased, whereas the levels of urea, glutathione, and sulfite ion decreased under any condition. Although the ratio of G-SH to oxidized glutathione (GS-SG) decreased, glutathione monosulfide (G-S-SH) and cysteine monosulfide (Cys-S-SH) increased after radon inhalation. G-S-SH and Cys-S-SH can produce a biological defense against the imbalance of the redox state at very low-dose irradiation following radon inhalation because they are strong scavengers of reactive oxygen species. Additionally, we performed an overall assessment of high-dimensional data and showed some specific characteristics. We showed the changes in metabolites after radon inhalation using partial least squares-discriminant analysis and self-organizing maps. The results showed the health effects of radon, especially the state of sulfur-related metabolites in mouse brains under the exposure conditions for radon therapy.

    DOI: 10.3390/ijerph191710750

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  • Radon Solubility and Diffusion in the Skin Surface Layers 査読

    Akihiro Sakoda, Tsuyoshi Ishida, Takahahiro Kataoka, Norie Kanzaki, Hiroshi Tanaka, Fumihiro Mitsunobu, Kiyonori Yamaoka

    International Journal of Environmental Research and Public Health 19(13), 7761, 2022   19 ( 13 )   7761 - 7761   2022年6月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MDPI AG  

    In specific situations such as bathing in a radon spa, where the radon activity concentration in thermal water is far higher than that in air, it has been revealed that radon uptake via skin can occur and should be considered for more precise dose evaluation. The primary aim of the present study was to numerically demonstrate the distribution as well as the degree of diffusion of radon in the skin, with a focus on its surface layer (i.e., stratum corneum). We developed a biokinetic model that included diffusion theory at the stratum corneum, and measured radon solubility in that tissue layer as a crucial parameter. The implementation of the model suggested that the diffusion coefficient in the stratum corneum was as low as general radon-proof sheets. After a 20-min immersion in water, the simulated depth profile of radon in the skin showed that the radon activity concentration at the top surface skin layer was approximately 103 times higher than that at the viable skin layer. The information on the position of radon as a radiation source would contribute to special dose evaluation where specific target cell layers are assumed for the skin.

    DOI: 10.3390/ijerph19137761

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  • A simple method for estimating the potential of the pyroelectric crystal surface 査読

    Katsumi Hanamoto, Takahiro Kataoka, Kiyonori Yamaoka

    Applied Radiation and Isotopes 185,110230, 2022   2022年4月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Dosimetry of radon progeny deposited on skin in air and thermal water 査読 国際誌

    Akihiro Sakoda, Yuu Ishimori, Norie Kanzaki, Hiroshi Tanaka, Takahiro Kataoka, Fumihiro Mitsunobu, Kiyonori Yamaoka

    Journal of Radiation Research   62 ( 4 )   634 - 644   2021年7月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Oxford University Press (OUP)  

    <title>Abstract</title>
    It is held that the skin dose from radon progeny is not negligibly small and that introducing cancer is a possible consequence under normal circumstances as there are a number of uncertainties in terms of related parameters such as activity concentrations in air and water, target cells in skin, skin covering materials, and deposition velocities. An interesting proposal has emerged in that skin exposure to natural radon-rich thermal water as part of balneotherapy can produce an immune response to induce beneficial health effects. The goal of this study was to obtain generic dose coefficients with a focus on the radon progeny deposited on the skin in air or water in relation to risk or treatment assessments. We thus first estimated the skin deposition velocities of radon progeny in air and thermal water based on data from the latest human studies. Skin dosimetry was then performed under different assumptions regarding alpha-emitting source position and target cell (i.e. basal cells or Langerhans cells). Furthermore, the impact of the radon progeny deposition on effective doses from all exposure pathways relating to ‘radon exposure’ was assessed using various possible scenarios. It was found that in both exposure media, effective doses from radon progeny inhalation are one to four orders of magnitude higher than those from the other pathways. In addition, absorbed doses on the skin can be the highest among all pathways when the radon activity concentrations in water are two or more orders of magnitude higher than those in air.

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  • The Effects of Low-Dose-Rate γ-irradiation on Forced Swim Test-Induced Immobility and Oxidative Stress in Mice. 査読

    Tetsuya Nakada, Takahiro Kataoka, Takaharu Nomura, Hina Shuto, Junki Yano, Shota Naoe, Katsumi Hanamoto, Kiyonori Yamaoka

    Acta Medica Okayama   75 ( 2 )   169 - 175   2021年4月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    The forced swim test (FST) induces immobility in mice. Low-dose (high-dose-rate) X-irradiation inhibits FSTinduced immobility in mice due to its antioxidative function. We evaluated the effects of low-dose γ-irradiation at a low-dose-rate on the FST-induced depletion of antioxidants in mouse organs. Mice received whole-body low-dose-rate (0.6 or 3.0 mGy/h) of low-dose γ-irradiation for 1 week, followed by daily FSTs (5 days). The immobility rate on day 2 compared to day 1 was significantly lower in the 3.0 mGy/h irradiated mice than in sham irradiated mice. The FST significantly decreased the catalase (CAT) activity and total glutathione (t-GSH) content in the brain and kidney, respectively. The superoxide dismutase (SOD) activity and t-GSH content in the liver of the 3.0 mGy/h irradiated mice were significantly lower than those of the non-FST-treated mice. The CAT activity in the lungs of mice exposed to 3.0 mGy/h γ-irradiation was higher than that of non-FST treated mice and mice treated with FST. However, no significant differences were observed in the levels of these antioxidant markers between the sham and irradiated groups except for the CAT activity in lungs. These findings suggest that the effects of low-dose-rate and low-dose γ-irradiation on FST are highly organ-dependent.

    DOI: 10.18926/AMO/61896

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  • Basic study on enhancement of antioxidant function by low- dose irradiation in mouse brain and its combined effect with ascorbic acid 査読

    Takahiro Kataoka, Yuto Yunoki, Norie Kanzaki, Kaori Sasaoka, Yusuke Kobashi, Tsuyoshi Ishida, Katsumi Hanamoto, Kiyonori Yamaoka

    Radioisotopes   69 ( 2 )   45 - 53   2020年7月

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    担当区分:責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Japan Radioisotope Association  

    DOI: 10.3769/radioisotopes.69.45

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  • Health Effects of Low Dose Radiation: Health Promotion by Radon Hot Spring and Its Risk 招待 査読

    Kiyonori Yamaoka

    Journal of Balneology, Climatology and Physical Medicine   83 ( 1 )   9 - 9   2020年

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    担当区分:責任著者   掲載種別:研究論文(学術雑誌)  

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  • 同位体をトレーサとしたラドン子孫核種の体内動態に関する研究 査読

    迫田晃弘, 神﨑訓枝, 田中裕史, 片岡隆浩, 山岡聖典

    日本健康開発雑誌   40 ( 6 )   90 - 94   2019年6月

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    担当区分:最終著者   掲載種別:研究論文(学術雑誌)  

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  • Reduction of radiation exposure in patients and cardiologists using a noise reduction technique in cardiac catheterization and percutaneous coronary intervention 査読

    Masayuki Kumashiro, Takahiro Kataoka, Shinobu Yokota, Shinobu Nakagawa, Fumiaki Kiyokawa, Hideki Mitsui, Shinji Osumi, Kiyonori Yamaoka

    Journal of JART   66 ( 2 )   45 - 57   2019年4月

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    担当区分:最終著者, 責任著者  

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  • 心臓カテーテル検査およびPCIにおける雑音低減技術を用いた患者と術者の被ばく低減効果 査読

    熊代正行, 片岡隆浩, 横田忍, 中川忍, 清川文秋, 光井英樹, 大角真司, 山岡聖典

    日本診療放射線技師会誌   65 ( 5 )   31 - 40   2018年10月

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    担当区分:最終著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • Knowledge discovery of suppressive effect of disease and increased anti-oxidative function by low-dose radiation using self-organizing map 査読

    Norie Kanzaki, Takahiro Kataoka, Yusuke Kobashi, Yuto Yunoki, Tsuyoshi Ishida, Akihiro Sakoda, Yuu Ishimori, Kiyonori Yamaoka

    Radioisotopes   67 ( 2 )   43 - 57   2018年7月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:(公社)日本アイソトープ協会  

    我々はこれまで、低線量放射線はマウス諸臓器中で抗酸化機能を亢進し、酸化ストレス関連疾患を抑制することを報告してきた。しかしながら、それらの結果は対象疾患も低線量放射線による処置の条件も様々で、有効性が立証された治療法は確立されていない。そこで、本研究では、それらの結果から低線量放射線の健康効果を明らかにすることを目的とし、ラドン療法のような低線量放射線を活用した治療法の新規適応症を探索した。データの解析には自己組織化マップ(SOM)を用い、不安定な抗酸化機能の変化を自己組織化マップの曖昧な表現で視覚的に直感的に捉えることにより、出力された疾患抑制効果と抗酸化機能亢進の関連性を検討した。その結果、ラドン療法の適応症である疼痛への効果には明らかな線量依存性があることがわかり、肝疾患や脳疾患においても、線量依存性はないもののその効果を期待できると予測できた。本研究は、ラドン療法のような低線量放射線を活用した治療法の応用に貢献できると考える。(著者抄録)

    DOI: 10.3769/radioisotopes.67.43

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    その他リンク: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2018&ichushi_jid=J01507&link_issn=&doc_id=20180220010001&doc_link_id=10.3769%2Fradioisotopes.67.43&url=https%3A%2F%2Fdoi.org%2F10.3769%2Fradioisotopes.67.43&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

  • ラドン吸入による抗酸化機能の亢進と抗酸化ビタミン摂取との複合効果に関する研究動向 査読

    片岡隆浩,山岡聖典

    放射線生物研究   53 ( 3 )   211 - 222   2018年6月

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  • Pressure dependence of X-rays produced by an LiTaO3 single crystal over a wide range of pressure 査読 国際誌

    Katsumi Hanamoto, Takahiro Kataoka, Kiyonori Yamaoka

    Applied Radiation and Isotopes   135   40 - 42   2018年5月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier Ltd  

    The energy spectra of X-rays produced by an LiTaO3 single crystal have been measured at the pressures of 8 × 10−4−4 Pa. The energy spectra showed that the endpoint energy steadily increased with decrease of pressure at 2–4 Pa and gradually decreased with decrease of pressure at 0.1–2 Pa, and became almost constant below 0.1 Pa. The amount of X-rays steadily increased with decrease of pressure at 2–4 Pa and almost saturated below 0.5 Pa. The change of X-rays produced by the LiTaO3 single crystal was compared with the previous works and discussed in relation to the distance between the crystal surface and the target.

    DOI: 10.1016/j.apradiso.2018.01.019

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  • Image Quality of the Coronary Angiography with Noise Reduction Technology to Decrease the Radiation Dose. 査読

    Masayuki Kumashiro, Takahiro Kataoka, Shinobu Yokota, Shinobu Nakagawa, Keisuke Otsuki, Nobuyuki Miyake, Shinji Osumi, Kiyonori Yamaoka

    Acta Medica Okayama   72 ( 2 )   153 - 164   2018年4月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    We examined the effects of a reduced exposure dose on the quality of images from an angiography device augmented with a noise reduction algorithm. Before its clinical application, we compared the diameter of the discrimination limit of the hole with that in the conventional method by a visual evaluation with a contrast-detail (C-D) phantom imaged using the target dose. Based on the results, a reducible dose was determined and applied clinically. The sample population consisted of patients being followed up after percutaneous coronary intervention (PCI) for coronary artery disease; we evaluated the effects of the exposure reduction on image quality. A significant dose reduction was observed by the noise-reduction method compared to the conventional method; the radiation dose to the flat panel detector (FPD) could be reduced to 70 nGy per frame. Clinically, a dose reduction of approx. 40% was obtained while maintaining image quality almost equal to that of the conventional method.

    DOI: 10.18926/AMO/55856

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  • Measurements of radon activity concentration in mouse tissues and organs 査読 国際誌

    Yuu Ishimori, Hiroshi Tanaka, Akihiro Sakoda, Takahiro Kataoka, Kiyonori Yamaoka, Fumihiro Mitsunobu

    Radiation and Environmental Biophysics   56 ( 2 )   161 - 165   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    The purpose of this study is to investigate the biokinetics of inhaled radon, radon activity concentrations in mouse tissues and organs were determined after mice had been exposed to about 1 MBq/m(3) of radon in air. Radon activity concentrations in mouse blood and in other tissues and organs were measured with a liquid scintillation counter and with a well-type HP Ge detector, respectively. Radon activity concentration in mouse blood was 0.410 +/- 0.016 Bq/g when saturated with 1 MBq/m(3) of radon activity concentration in air. In addition, average partition coefficients obtained were 0.74 +/- 0.19 for liver, 0.46 +/- 0.13 for muscle, 9.09 +/- 0.49 for adipose tissue, and 0.22 +/- 0.04 for other organs. With these results, a value of 0.414 for the blood-to-air partition coefficient was calculated by means of our physiologically based pharmacokinetic model. The time variation of radon activity concentration in mouse blood during exposure to radon was also calculated. All results are compared in detail with those found in the literature.

    DOI: 10.1007/s00411-017-0682-9

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  • Study on antidepressant-like effects of radon inhalation on forced swim induced depression in mice 査読

    K.Yamato, T.Kataoka, Y.Nishiyama, Yuji Takata, R.Etani, K.Yamaoka

    Radioisotopes   65 ( 12 )   493 - 506   2016年12月

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    担当区分:最終著者, 責任著者   記述言語:英語  

    DOI: 10.3769/radioisotopes.65.493

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  • Pressure dependence of X-rays produced by an LiTaO3 single crystal at the pressures of 1-20 Pa 査読 国際誌

    Katsumi Hanamoto, Takahiro Kataoka, Kiyonori Yamaoka

    Applied Radiation and Isotopes   116   134 - 137   2016年10月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    The energy spectra of X-rays produced by an LiTaO3 single crystal have been measured at pressures of 1-20 Pa. The energy spectra showed that the endpoint energy and the amount of X-rays gradually increased with the decrease of pressure at 5-8 Pa and abruptly increased around 4 Pa and below. A maximum endpoint energy of 70 keV was obtained using the LiTaO3 single crystal with 5 mm thickness at a pressure of 3 Pa. The change of X-rays produced by the LiTaO(3)single crystal was discussed in relation to the breakdown potential at the pressures. (C) 2016 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.apradiso.2016.08.003

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  • Possible applications of radon therapy in veterinary care for oxidative stress-induced kidney damage 査読

    Kaori Sasaoka, Takahiro Kataoka, Norie Kanzaki, Kiyonori Yamaoka

    Free Radicals and Health   61 - 74   2016年1月

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    担当区分:最終著者, 責任著者   掲載種別:論文集(書籍)内論文  

    Oxidative stress in the body is considered an imbalance between the production and removal of reactive oxygen species (ROS). Ischemic acute renal failure, chronic renal failure, uremia, glomerulonephritis, and diabetic nephropathy are ROS-related diseases. In the veterinary field, a few studies of chronic kidney failure related to oxidative stress have been reported. Radon therapy has been used in Japan and Europe, and has been shown to have beneficial effects on ROS-related diseases such as bronchial asthma, arteriosclerosis, osteoarthritis, and pain-related diseases. We have demonstrated that radon inhalation increases antioxidative functions in kidney, and inhibits oxidative stress-induced kidney damage in animals. In addition, radon exposure systems for pets have already been developed. Therefore, we review the possible applications of radon therapy in veterinary care for oxidative stress-induced kidney damage.

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  • 三朝ラドン温泉の健康効果に関する最近の研究動向 招待 査読

    片岡隆浩, 迫田晃弘, 恵谷玲央, 石森 有, 光延文裕, 山岡聖典

    温泉科学(日本温泉科学会学会誌)   64 ( 4 )   380 - 387   2015年8月

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    担当区分:最終著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • The possible applications of radon inhalation treatment as antioxidant therapy for hepatopathy 招待 査読

    Takahiro Kataoka, Akihiro Sakoda, Reo Etani, Yuu Ishimori, Fumihiro Mitsunobu, Kiyonori Yamaoka

    Radon: Geology, Environmental Impact and Toxicity Concerns   133 - 148   2015年1月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:論文集(書籍)内論文  

    The possibility of antioxidant therapy has been reported for several diseases such as ischemic stroke. The therapy could also be applied for diseases caused by reactive oxygen species (ROS). It has been reported that ROS or free radicals may cause various types of hepatopathy, including alcoholic liver disease. Low dose (0.5 Gy) X- or γ- irradiation activates the antioxidative functions of the mouse liver and inhibits ROS- or free radical-induced hepatopathy. Radon therapy is performed mainly for pain-related diseases in Japan and Europe. Several clinical studies have been reported, but the possible mechanisms of the beneficial effects remain unknown. Recently, we have reported that the possible mechanism of radon therapy is the activation of antioxidative functions following radon inhalation. For example, radon inhalation inhibits and alleviates chronic constriction injury induced pain or inflammatory pain in mice due to the activation of antioxidative functions. In addition, although hepatopathy is not the main indication for radon therapy, our recent studies suggested that radon inhalation inhibits hepatopathy caused by ROS or free radicals. In this chapter, based on experiments with mice, we reviewed the possible applications of radon inhalation as an antioxidant therapy for hepatopathy from the viewpoints of recent antioxidant therapy, hepatopathy induced by ROS or free radicals, and the beneficial effects of radon inhalation for hepatopathy.

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  • ラジウム・ラドン温泉の健康効果-ラドン療法の効果と機構に関する最近の研究動向- 招待

    山岡聖典

    健康と温泉フォーラム   22 - 29   2014年10月

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    担当区分:責任著者   掲載種別:研究論文(研究会,シンポジウム資料等)  

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  • ラドンの健康影響に関する一考察 -ラドン療法の効果と機構に関する最近の研究動向- 査読

    西山祐一, 片岡隆浩, 山岡聖典

    日本原子力学会和文論文誌   12 ( 4 )   267 - 276   2013年12月

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    担当区分:最終著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • ラドン温泉はがんの予防や治療に有効か? 招待 査読

    山岡聖典

    日本がん予防学会 NEWS LETTER   77   3 - 3   2013年9月

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  • Absorbed doses of lungs from radon retained in airway lumens of mice and rats 査読 国際誌

    Akihiro Sakoda, Yuu Ishimori, Kiyonori Yamaoka, Takahiro Kataoka, Fumihiro Mitsunobu

    Radiation and Environmental Biophysics   52 ( 3 )   389 - 395   2013年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    This paper provides absorbed doses arising from radon gas in air retained in lung airway lumens. Because radon gas exposure experiments often use small animals, the calculation was performed for mice and rats. For reference, the corresponding computations were also done for humans. Assuming that radon concentration in airway lumens is the same as that in the environment, its progeny's production in and clearance from airways were simulated. Absorbed dose rates were obtained for three lung regions and the whole lung, considering that secretory and basal cells are sensitive to radiation. The results showed that absorbed dose rates for all lung regions and whole lung generally increase from mice to rats to humans. For example, the dose rates for the whole lung were 25.4 in mice, 41.7 in rats, and 59.9 pGy (Bq m(-3))(-1) h(-1) in humans. Furthermore, these values were also compared with lung dose rates from two other types of exposures, that is, due to inhalation of radon or its progeny, which were already reported. It was confirmed that the direct inhalation of radon progeny in the natural environment, which is known as a cause of lung cancer, results in the highest dose rates for all species. Based on the present calculations, absorbed dose rates of the whole lung from radon gas were lower by a factor of about 550 (mice), 200 (rats), or 70 (humans) than those from radon progeny inhalation. The calculated dose rate values are comparatively small. Nevertheless, the present study is considered to contribute to our understanding of doses from inhalation of radon and its progeny.

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  • ラドン療法に関する最近の研究動向- 鎮痛効果に着目して- 査読

    大和恵子, 片岡隆浩, 西山祐一, 山岡聖典

    放射線生物研究   48 ( 1 )   66 - 81   2013年2月

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  • Lung dosimetry of inhaled radon progeny in mice 査読 国際誌

    Akihiro Sakoda, Yuu Ishimori, Kosuke Fukao, Kiyonori Yamaoka, Takahiro Kataoka, Fumihiro Mitsunobu

    Radiation and Environmental Biophysics   51 ( 4 )   425 - 442   2012年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    Biological response of exposure to radon progeny has long been investigated, but there are only few studies in which absorbed doses in lungs of laboratory animals were estimated. The present study is the first attempt to calculate the doses of inhaled radon progeny for mice. For reference, the doses for rats and humans were also computed with the corresponding models. Lung deposition of particles, their clearance, and energy deposition of alpha particles to sensitive tissues were systematically simulated. Absorbed doses to trachea and bronchi, bronchioles and terminal bronchioles, alveolar-interstitial regions, and whole lung were first provided as a function of monodisperse radon progeny particles with an equilibrium equivalent radon concentration of 1 Bq m(-3) (equilibrium factor, 0.4 and unattached fraction, 0.01). Based on the results, absorbed doses were then calculated for (1) a reference mine condition and (2) a condition previously used for animal experiments. It was found that the whole lung doses for mice, rats, and humans were 34.8, 20.7, and 10.7 nGy (Bq m(-3))(-1) h(-1) for the mine condition, respectively, while they were 16.9, 9.9, and 6.5 nGy (Bq m(-3))(-1) h(-1) for the animal experimental condition. In both cases, the values for mice are about 2 times higher than those for rats, and about 3 times higher than those for humans. Comparison of our data on rats and humans with those published in the literature shows an acceptable agreement, suggesting the validity of the present modeling for mice. In the future, a more sophisticated dosimetric study of inhaled radon progeny in mice would be desirable to demonstrate how anatomical, physiological, and environmental parameters can influence absorbed doses.

    DOI: 10.1007/s00411-012-0431-z

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  • Activation of biodefense system by low-dose irradiation or radon inhalation and its applicable possibility for treatment of diabetes and hepatopathy. 査読 国際誌

    Takahiro Kataoka, Kiyonori Yamaoka

    ISRN Endocrinology, Volume 2012 (2012), Article ID 292041, 11 pages   2012年7月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Adequate oxygen stress induced by low-dose irradiation activates biodefense system, such as induction of the synthesis of superoxide dismutase (SOD) and glutathione peroxidase. We studied the possibility for alleviation of oxidative damage, such as diabetes and nonalcoholic liver disease. Results show that low-dose γ-irradiation increases SOD activity and protects against alloxan diabetes. Prior or post-low-dose X- or γ-irradiation increases antioxidative functions in livers and inhibits ferric nitrilotriacetate and carbon tetrachloride-induced (CCl(4)) hepatopathy. Moreover, radon inhalation also inhibits CCl(4)-induced hepatopathy. It is highly possible that low-dose irradiation including radon inhalation activates the biodefence systems and, therefore, contributes to preventing or reducing reactive oxygen species-related diabetes and nonalcoholic liver disease, which are thought to involve peroxidation.

    DOI: 10.5402/2012/

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  • Inhibitory Effects of Pre and Post Radon Inhalation on Carbon Tetrachloride-induced Oxidative Damage in Mouse Organs 査読

    Y.Nishiyama, T.Kataoka, J.Teraoka, A.Saokda, Y.Ishimori, K.Yamaoka

    Radioisotopes   61 ( 5 )   231 - 241   2012年5月

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    担当区分:最終著者, 責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Japan Radioisotope Association  

    DOI: 10.3769/radioisotopes.61.231

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  • Pressure dependence of X-rays produced by an LiTaO3 single crystal at low pressures 査読

    Katsumi Hanamoto, Atsushi Kawabe, Akihiro Sakoda, Takahiro Kataoka, Mari Okada, Kiyonori Yamaoka

    Nuclear Instruments and Methods in Physics Research A   669   66 - 69   2012年3月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    The energy spectra of X-rays produced by an LiTaO3 single crystal have been measured at pressures of 5-50 Pa. The energy spectra showed that the amount of X-rays increased exponentially and the endpoint energy of the spectra increased linearly with the decrease of pressure at pressures of 10-25 Pa. A maximum endpoint energy of about 22 key was obtained using an LiTaO3 single crystal with 0.5 mm thickness at the pressure of 10 Pa. The maximum energy produced by the present experimental setup was estimated assuming that the LiTaO3 single crystal forms a parallel-plate capacitor. The estimated energy reasonably agreed with the energy obtained. The pressure dependence of the endpoint energy was discussed in relation to the breakdown potential at low pressures. (C) 2011 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.nima.2011.12.028

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  • ラドン吸入がペットの健康改善に及ぼす効果に関する基礎的検討 査読

    片岡隆浩, 徳永力三, 迫田晃弘, 川辺 睦, 花元克巳, 山岡聖典

    Radioisotopes   61 ( 1 )   1 - 8   2012年1月

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    担当区分:最終著者, 責任著者   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3769/radioisotopes.61.1

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  • Activation of bio-defense system by radon inhalation and its applicable possibility for treatment of lifestyle diseases 招待 査読

    Takahiro Kataoka, Akihiro Sakoda, Yuu Ishimori, Fumihiro Mitsunobu, Kiyonori Yamaoka

    Handbook of Radon: Properties, Applications and Health   335 - 356   2012年1月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:論文集(書籍)内論文  

    Adequate oxygen stress induced by radon inhalation activates chemical biological protective functions, such as induction of the synthesis of superoxide dismutase and glutathione peroxidase. We studied the probability that activation of this function alleviated various oxidation injuries. The results showed that 1) Radon inhalation enhanced the antioxidative function and membrane fluidity in some mouse organs, and biogenic amine neurotransmitters in the rabbit brain; 2) To elucidate a more effective condition for radon inhalation, mice inhaled radon before carbon tetrachloride (CCl4) administration. The results show that radon inhalation alleviates CCl4-induced hepatopathy; 3) Radon inhalation elevated antioxidant enzymes in patients with bronchial asthma and osteoarthritis; 4) Radon inhalation alleviated the symptoms of hypertension, diabetes and pain in humans; 5) Radon inhalation elevated the p53 protein level and SOD activity in the blood of residents of the Misasa radon hot spring district. Moreover, we compared biochemically the radon effects and thermal effects on humans in radon hot spring therapy, the effects of thoron and thermal treatment for aging-related diseases in humans, and the effects of radon inhalation on acute alcohol-induced oxidative injury of the liver and brain in mice. These findings suggest that radon inhalation alleviates various reactive oxygen species-related injuries. It is highly possible that adequate activation of the functions of the living body by radon inhalation can contribute to preventing or reducing reactive oxygen species-related injuries (lifestyle diseases) which are thought to involve peroxidation. © 2012 by Nova Science Publishers, Inc. All rights reserved.

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  • A Comparative Study on effect of continuous radon inhalation on several-time acute alcohol-induced oxidative damage of liver and brain in mouse 査読

    T.Kataoka, A.Sakoda, M.Yoshimoto, Teruaki Toyota, Yuki Yamamoto, Y.Ishimori, K.Hanamato, A.Kawabe, F.Mitsunobu, K.Yamaoka

    Radiation Safety Management   10 ( 1 )   1 - 7   2011年12月

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    担当区分:最終著者, 責任著者   掲載種別:研究論文(学術雑誌)  

    DOI: 10.12950/rsm.10.1

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  • 低線量放射線の健康への有益効果と医療への応用の可能性 招待 査読

    山岡聖典

    学術の動向(日本学術協力財団)   16 ( 11 )   75 - 79   2011年11月

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    担当区分:責任著者   掲載種別:研究論文(学術雑誌)  

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  • 放射線とアンチ・エイジング:低線量放射線による老化・生活習慣病の抑制の可能性 招待 査読

    山岡聖典

    アンチ・エイジング医学(日本抗加齢医学会雑誌)   7 ( 5 )   48 - 54   2011年10月

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    担当区分:責任著者   掲載種別:研究論文(学術雑誌)  

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  • Performance of the First Japanese Large-Scale Facility for Exposing Small Animals to Radon 査読 国際誌

    Yuu Ishimori, Fumihiro Mitsunobu, Kiyonori Yamaoka, Hiroshi Tanaka, Takahiro Kataoka, Akihiro Sakoda

    Radiation Protection Dosimetry   146 ( 1-3 )   31 - 33   2011年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OXFORD UNIV PRESS  

    A radon test facility for small animals was developed in order to increase the statistical validity of differences of the biological response in various radon environments. This paper illustrates the performances of that facility, the first large-scale facility of its kind in Japan. The facility has a capability to conduct approximately 150 mouse-scale tests at the same time. The apparatus for exposing small animals to radon has six animal chamber groups with five independent cages each. Different radon concentrations in each animal chamber group are available. Because the first target of this study is to examine the in vivo behaviour of radon and its effects, the major functions to control radon and to eliminate thoron were examined experimentally. Additionally, radon progeny concentrations and their particle size distributions in the cages were also examined experimentally to be considered in future projects.

    DOI: 10.1093/rpd/ncr100

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  • An Assessment of Radioactivity Levels of Pb-210 and K-40 in Tobacco and Radiation Exposure from Smoking 査読

    Tomohiro Nagamatsu, Akihiro Sakoda, Takahiro Kataoka, Toshiro Ono, Kiyonori Yamaoka

    Acta Medica Okayama   65 ( 2 )   91 - 95   2011年4月

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    担当区分:最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    No research has been conducted on the radiation influence of tobacco on the alimentary system, although there have been some previous works on the respiratory system. In this study, the radioactive concentrations of Pb-210 and K-40 in a cigarette sample were first measured. The transfer factors of the nuclides from tobacco into smoke and solution (saliva and/or alcohol) were then examined. Moreover, the radiation doses from smoke inhalation were also evaluated. The radioactive concentrations of Pb-210 and K-40 in the cigarette tobacco were 0.01 and 0.3 Bq/cigarette. Since this Pb-210 activity and the Po-210 activity previously reported for the same sample were comparable, it can be concluded that there was a radioactive equilibrium between the 2 nuclides. The observed transfer factor of Pb-210 (12%) into smoke was almost the same as that of K-40 (15%), whereas the reported value for Po-210 (60%) was significantly higher. The radiation doses due to inhalation of cigarette smoke varied from organ to organ, depending on the organotropic properties of the nuclide. For example, the kidneys, respiratory tract, and spleen showed relatively high doses from Pb-210 and Po-210. The leaching rates indicated an inconsistent tendency related to solution types. This result could suggest that alcohol drinking, which is common in smokers, does not especially enhance the leaching characteristics.

    DOI: 10.18926/AMO/45267

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  • 小動物病院におけるX線撮影に伴う放射線診療従事者の実効線量評価 査読

    川辺 睦, 山田一孝, 花元克巳, 迫田晃弘, 片岡隆浩, 山岡聖典

    動物臨床医学   19 ( 4 )   113 - 117   2010年8月

  • 総説 ラドンの健康効果に関する最近の研究動向 招待 査読

    山岡聖典

    日本機能性イオン協会誌   16 ( 1 )   2 - 7   2010年5月

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    担当区分:責任著者   掲載種別:研究論文(大学,研究機関等紀要)  

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  • AIR GAP代用法によるIVR患者被ばく低減のモンテカルロ検証 査読

    川辺 睦, 佐藤 斉, 迫田晃弘, 片岡隆浩, 花元克巳, 深井喜代子, 三村秀文, 山岡聖典

    医学物理   30 ( 2 )   351 - 352   2010年4月

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  • Primary Functions of the First Japanese Large-Scale Facility for Exposing Small Animals to Radon 査読

    Y.Ishimori, F.Mitsunobu, K.Yamaoka, Hiroshi Tanaka, T.Kataoka, A.Sakoda

    Japanese Journal of Health Physics   45 ( 1 )   65 - 71   2010年3月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Japan Health Physics Society  

    DOI: 10.5453/jhps.45.65

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  • 日本初の大規模な小動物のラドン吸入試験設備の主な機能 査読

    石森有, 光延文裕, 山岡聖典, 田中裕史, 片岡隆浩, 迫田晃弘

    保健物理   45 ( 1 )   65 - 71   2010年3月

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  • An Assessment of Radioactivity Level in 51Cr-Contaminated Dry Solid Waste Generated from a Research Facility for Verification of Clearance Levels 査読

    T.Nagamatsu, T.Hanafusa, T.Ono, K.Yamaoka

    Radiation Safety Management   9 ( 1 )   7 - 12   2010年1月

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    担当区分:最終著者   記述言語:英語   出版者・発行元:Japanese Society of Radiation Safety Management  

    Radioactive waste generated from research laboratories and other facilities is regulated by the Law Concerning Prevention from Radiation Hazards due to Radioisotopes etc. (Prevention Law). However, the Prevention Law does not provide the level of clearance or the procedures to follow for compliance monitoring. To assess radioactivity amounts for making decisions about clearance levels, the radioactivity levels in dry solid semi-combustible wastes generated from biomedical research, such as 51Cr-release assays, were measured and evaluated. Radioactivity of semi-combustible waste was 1.42-6.32% of the initial level. In comparison, records for the past 8 years in the Shikata Laboratory, Department of Radiation Research, Okayama University Advanced Science Research Center, indicated 7% to 90% of the initial radioactivity remained in the waste and was differed widely among researchers. This study determined an accurate radioactivity level in dry solid waste, which could lead to savings in disposal costs.<br>

    DOI: 10.12950/rsm.9.7

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  • 放射線影響を考える-動物実験から見えてきたこと-:低線量放射線による抗酸化機能の亢進と酸化障害の緩和の可能性 招待 査読

    山岡聖典

    アニテックス   21 ( 3 )   8 - 13   2009年5月

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    担当区分:責任著者   掲載種別:論文集(書籍)内論文  

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  • 低線量放射線の健康への影響と医療への応用 招待 査読

    山岡聖典

    日本臨床矯正歯科医会雑誌   21 ( 1 )   14 - 19   2009年1月

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    担当区分:責任著者   掲載種別:研究論文(学術雑誌)  

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  • 岡山大学における核燃料物質の安全管理のための劣化ウランと天燃ウランの鑑別について 査読

    永松知洋, 花房直志, 金野郁雄, 迫田晃弘, 花元克巳, 山岡聖典, 小野俊朗

    環境制御   30 ( 1 )   33 - 37   2008年12月

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    記述言語:日本語   出版者・発行元:岡山大学環境管理センター  

    In Japan, the Law for the Regulation of Nuclear Source Materials, Nuclear Fuel Materials and Reactors (Regulation Law) controls the nuclear fuel materials such as thorium (Th), uranium (U) and plutonium (Pu). Under the Regulation Law, all related materials and reactors are needed to register to the Government. In Okayama University, many nuclear fuel materials, mainly uranium compounds, are registered and stored in 11 departments, separately. Discrimination between depleted uranium and natural uranium is important for the observance of the Regulation Law and the safety management of the nuclear fuel materials in the Okayama University. However, the discrimination of the two kind of uranium has poorly analyzed. In this study, we analyzed several uranium compounds by using γ-ray spectrometry to determine whether the depleted uranium or not.

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    その他リンク: http://ousar.lib.okayama-u.ac.jp/14695

  • 低線量放射線の世界-その効用研究の現段階-:低線量放射線の健康への影響と医療への応用に関する研究 招待 査読

    山岡聖典

    原子力eye   54 ( 9 )   5 - 9   2008年9月

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    担当区分:責任著者   掲載種別:論文集(書籍)内論文  

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  • ラドン吸入試作装置によるマウス諸臓器中の抗酸化機能の亢進に関する研究 査読

    中川慎也, 片岡隆浩, 迫田晃弘, 石森 有, 花元克巳, 山岡聖典

    Radioisotopes   57 ( 4 )   241 - 251   2008年4月

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    担当区分:最終著者, 責任著者   記述言語:日本語   出版者・発行元:(公社)日本アイソトープ協会  

    医学的効果が再現でき、かつ、汎用性のある小動物実験用ラドン吸入装置を試作した。ラドン療法の適応症の機構解明に資するため、試作装置を用い、マウスへのラドン吸入による医学的効果の程度を知り得る抗酸化機能の変化特性を検討した。マウスに400Bq/m3あるいは4000Bq/m3のラドンを吸入させた。脳・肺・肝臓・腎臓において、抗酸化系酵素であるSODとカタラーゼの両活性が増加し、過酸化脂質量が減少した。この抗酸化機能の亢進により、ラドン吸入は活性酸素障害の抑制、すなわち、生活習慣病の予防や症状緩和に効呆のある可能性が示唆された。

    DOI: 10.3769/radioisotopes.57.241

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  • Methodological Approach for Assessment of the Radioactivity Level in Dry Solid Waste 査読

    T.Nagamatsu, A.Sakoda, K.Hanamoto, I.Kinno, T.Hanafusa, K.Yamaoka, T.Ono

    Radiation Safety Management   7 ( 1 )   6 - 10   2008年1月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.12950/rsm2002.7.6

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  • 放射線ホルミシス研究の現状と今後 招待 査読

    山岡聖典

    電気評論   503 ( 91 )   51 - 55   2006年11月

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    担当区分:責任著者   掲載種別:研究論文(研究会,シンポジウム資料等)  

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  • 埋蔵文化財発掘調査及び建設工事が環境放射線へ及ぼす影響評価 査読

    永松知洋, 花元克巳, 小野俊朗, 山岡聖典

    環境制御   27   11 - 16   2005年12月

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    担当区分:最終著者  

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  • 人工トロン温泉由来の放射能と負イオン(マイナスイオン)の諸特性 査読

    迫田晃弘, 片岡隆浩, 花元克巳, 山岡聖典

    Radioisotopes   54 ( 9 )   19 - 27   2005年9月

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    担当区分:最終著者, 責任著者   記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:(公社)日本アイソトープ協会  

    実際の人工ラドン温泉で利用されている加工した粉末状のモナズ石を水に浸すことで温泉状態を模擬するなどし,その際の放射能とマイナスイオンの基礎的特性について検討した.モナズ石含有のトリゥム系列核種とウラン系列核種の比放射能比は5.3であった.モナズ石含有核種の水への溶出率のpH(3.5〜12.5)依存性は,228Acと212Pbではモナズ石含有の高イオン化傾向の希土類元素のため酸性側ほど溶出率が大きくなったが,214Biと214Pbではモナズ石含有のそれら自体が少ないため有意に検出されなかった.モナズ石由来の空気中イオン量はモナズ石近傍ほど(10cm以内)多く,放出されるα線の飛程にほぼ一致した.また,空気中の相対湿度(35〜60%)が高いほど空気中イオン量も増加し,水和型で安定・存在することと一致した.更に,α線が水を電離する量はモナズ石の表面近辺で多かった

    DOI: 10.3769/radioisotopes.54.375

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  • 低線量放射線による抗酸化機能の亢進と酸化傷害の緩和に関する研究 招待 査読

    山岡聖典

    過酸化脂質研究   29 ( 1 )   23 - 26   2005年2月

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  • 三朝温泉におけるラドン療法とその機構解明の現状 招待 査読

    山岡聖典

    日本保健物理学会 水中ラドンに関する専門研究会活動報告書   103 - 106   2004年8月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(研究会,シンポジウム資料等)  

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  • 低線量放射線の生体への影響 招待 査読

    山岡聖典

    Radiology Frontier   7 ( 4 )   13 - 17   2004年4月

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  • 呼吸器疾患に対する温泉療法―その臨床効果と作用機序― 査読

    光延文裕, 保崎泰弘, 芦田耕三, 濱田全紀, 山岡聖典, 谷崎勝朗

    岡大三朝医療センター研究報告   75   61 - 63   2004年3月

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    記述言語:日本語   出版者・発行元:岡山大学医学部・歯学部附属病院三朝医療センター  

    呼吸器疾患に対する温泉療法の作用機序としては,直接作用として,自・他覚症状の改善,換気機能の改善,気道過敏性の改善,気道抵抗の低下,肺の過膨脹の改善,過分泌の抑制などが観察される.一方,間接作用としては,副腎皮質機能の改善,精神的リラックス,抗酸化酵素であるSOD活性の亢進などが観察され,これらの間接作用も気管支喘息の病態改善に重要な役割を果しているものと考えられる

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  • Using Physiological Indices to Consideration the Effects of Negative Air Ions on the Human Body 査読

    K.Shirai, K.Yamaoka, K.Hanamoto, N.Yamamoto

    Journal of International Society of Life Information Science   22 ( 1 )   97 - 102   2004年3月

  • Histidine-rich glycoprotein plus zinc reverses growth inhibition of vascular smooth muscle cells by heparin 査読 国際誌

    S Mori, R Shinohata, M Renbutsu, HK Takahashi, YI Fang, K Yamaoka, M Okamoto, Yamamoto, I, M Nishibori

    Cell and Tissue Research   312 ( 3 )   353 - 359   2003年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER-VERLAG  

    Vascular smooth muscle cell (SMC) hyperplasia is known to be an important component in the pathogenesis of arteriosclerosis and restenosis. Although heparin has been well recognized as the representative molecule suppressing SMC growth in vitro, attempts to use heparin as a therapeutic anti-restenosis drug have not favorably influenced the angiographic or clinical outcome after angioplasty in some clinical trials. In this study, we have examined the effect of histidine-rich glycoprotein (HRG), a relatively abundant serum glycoprotein (similar to100 mug/ml in human serum), on the growth inhibition of cultured vascular SMC by heparin. Vascular SMC growth was significantly inhibited by heparin, giving nearly 85% inhibition with 100 mug/ml heparin. HRG reversed heparin-induced SMC growth inhibition in a dose dependent manner; 75% restoration of cell growth was observed when 100 mug/ml of HRG was co-added with 100 mug/ml heparin. Interestingly, micromolar concentrations of the zinc ion (0-10 muM), compatible with concentrations released from activated platelets, were found to enhance the restorative action of HRG. Western blot experiment demonstrated no significant amounts of the HRG moiety in fetal bovine serum, eliminating the possible contribution of contaminant HRG from culture media. These findings indicate that HRG, in combination with the zinc ion, plays a role in modulating the SMC growth response in pathophysiological states and explain the lack of success of heparin as a therapeutic anti-restenosis drug in clinical trials.

    DOI: 10.1007/s00441-003-0737-x

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  • 低線量放射線が低カタラーゼマウスにおけるカタラーゼを含む抗酸化物質に及ぼす効果の検証 査読

    野村崇治, 山岡聖典, 森秀治, 汪達紘, 吉良尚平, 酒井一夫

    電力中央研究所研究報告   G03001   2003年5月

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  • High affinity binding of serum histidine-rich glycoprotein to nickel-nitrilotriacetic acid: The application to microquantification 査読 国際誌

    S Mori, HK Takahashi, K Yamaoka, M Okamoto, M Nishibori

    Life Sciences   73 ( 1 )   93 - 102   2003年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    Histidine-rich glycoprotein (HRG) is a serum protein with possible pluripotent activities. In this study, a method for the quantification of rabbit histidine-rich glycoprotein (rHRG) was developed based upon the high affinity binding profile of rHRG to nickel-nitrilotriacetic acid (Ni-NTA), an improved chelation agent. When the binding profile of Ni-NTA for whole serum proteins was assessed by Western blotting, Ni-NTA exhibited the binding specificity only to rHRG even after washing with 20 mM imidazole, owing to the unusual amounts of histidine residues in rHRG. In the following experiments, the rHRG immobilized onto a microplate with specific antibody was determined spectrophotometrically with peroxidase-labeled Ni-NTA. This method permitted evaluation of rHRG concentrations ranging from 1.0 to 100 ng/ml, and was actually applicable to the monitoring of rHRG in Resource Q-fractionated serum preparations. Also, the co-addition of L-histidine into the incubation mixture significantly diminished the specific binding between rHRG and Ni-NTA. These findings indicate the potential usefulness of this method for the specific measurement of small amounts of rHRG and for understanding the roles of abundant histidine residues in rHRG-metal cation interaction. (C) 2002 Elsevier Science Inc. All rights reserved.

    DOI: 10.1016/S0024-3205(03)00261-3

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  • MR imaging of vertebral metastases at 0.2 Tesla: Clinical evaluation of T1-weighted opposed-phase gradient-echo imaging 査読 国際誌

    Seiichiro Ohno, Izumi Togami, Tetsuro Sei, Kentaro Ida, Masatoshi Tsunoda, Kiyonori Yamaoka, Susumu Kanazawa, Yoshio Hiraki

    Physiological Chemistry & Physics and Medical NMR   35 ( 2 )   145 - 156   2003年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The purpose of this study was to evaluate clinically T1-weighted spin-echo imaging (T1-SE) and T1-weighted opposed-phase gradient-echo (T1-opposed GRE) in medical examinations for vertebral metastases using 0.2 Tesla MRI. Twenty-one patients (9 males and 12 females, 105 vertebrae) with non-neoplastic lesions were assigned to the normal group (Group N), whereas 27 patients (16 males and 11 females, 133 vertebrae) with malignant metastatic vertebral lesions were assigned to the metastatic group (Group M). Using quantitative analysis, the contrast to noise ratio (CNR) for bone marrow to muscle in the region of interest (ROI) defined by the operator were determined with both groups, whereas the CNR for lesion to bone marrow was determined with Group M. In the subjective analysis, 275 vertebrae of 27 patients in Group M were evaluated. There were significant differences in the Group M between CNR values, T1-SE and T1-opposed GRE. The evaluation by T1-SE image alone was rated as 85.0% for sensitivity, 99.3% for specificity, respectively. On the other hand, evaluation rate only by T1-opposed GRE was 98.5% for sensitivity, 82.4% for specificity, respectively. T1-opposed GRE image is an effective tool for 0.2 Tesla MRI to examine metastatic bone marrow tumors. These findings indicate the necessity of both T1-SE and T1-opposed GRE in diagnostic imaging of vertebral metastases using 0.2 Tesla MRI.

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  • Elevation of antioxidant enzymes in the clinical effects of radon and thermal therapy for bronchial asthma 査読 国際誌

    F Mitsunobu, K Yamaoka, K Hanamoto, S Kojima, Y Hosaki, K Ashida, K Sugita, Y Tanizaki

    Journal of Radiation Research   44 ( 2 )   95 - 99   2003年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN RADIATION RESEARCH SOC  

    An increased systemic production of oxygen-free radicals by activated inflammatory cells is thought to be involved in the pathophysiology of asthma. The aim of this study is to evaluate the clinical effects of radon and thermal therapy on asthma in relation to antioxidant enzymes and lipid peroxide. Radon and thermal therapy were performed once a week. All subjects went to a hot bathroom with a high concentration of radon, and nasal inhalation of vapor from a hot spring was performed for 40 min once a day under conditions of high humidity. The room temperature was 48degreesC; the room radon concentration was 2,080 Bq/m(3). Blood samples were collected at 2 h, 14, and 28 days after the first therapy. A blood sample also was collected before the first therapy (at body temperature and background radon level) to be used as the control. The forced expiratory volume in one second (%FEV1) was significantly increased 28 days after the first therapy. Oil day 28, the catalase (CAT) activity was significantly increased in comparison with the control. The superoxide dismutase (SOD) activity was significantly increased compared to the control after first inhalation. On days 14 and 28, the lipid peroxide level was significantly decreased in comparison with the control. In conclusion, the present pilot study has shown that radon and thermal therapy improved the pulmonary function of asthmatics by increasing the reduced activities of antioxidant enzymes.

    DOI: 10.1269/jrr.44.95

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  • 化学発がんの非遺伝毒性的メカニズムの解明に関する最近の動向 査読

    山岡聖典, 花元克巳, 稲 恭宏, 片岡隆浩, 佐野正展, 川辺 睦, 氏福亜矢子

    岡山大学医学部保健学科紀要   14 ( 1 )   1 - 14   2003年3月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(大学,研究機関等紀要)  

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  • Activation of Chemical Biological Defense Mechanisms and Alleviation of in vivo Oxidation Injury by Low Dose Radiation 招待 査読

    Kiyonori Yamaoka, Shuji Kojima

    Molecular Mechanisms for Radiation-induced Cellular Response and Cancer Development   210 - 216   2002年10月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:論文集(書籍)内論文  

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  • Elevation of antioxidants in the kidneys of mice by low-dose irradiation and its effect on Fe3+–NTA-induced kidney damage 査読

    T. Nomura, K. Yamaoka, K. Sakai

    Radiation and Homeostasis   1236   481 - 485   2002年7月

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    記述言語:英語  

    We previously examined the effects of 0.5 Gy of γ- or X-irradiation on endogenous antioxidative materials, including glutathione, glutathione-related enzymes, superoxide dismutase and catalase in the liver, pancreas and brain of mice. An increase in the antioxidants was observed soon after the irradiation. We also demonstrated that the low-dose irradiation gave suppressive effects on reactive oxygen species (ROS)-related disease models such as acute hepatitis, type I diabetes and Parkinson's disease. These results suggested that the suppression or inhibition of the ROS-related diseases were made through the elevation of the antioxidants. We studied the effects of irradiation (0.5 Gy of γ-ray) reducing the renal oxidative damage in Fe3+ nitrilotri-acetate (NTA) injected mice. We examined transaminase activity, lipid peroxide level and those levels of antioxidants in the mouse. Both transaminase activities and lipid peroxide level accelerated decrease to normal level by the irradiation. The levels of total glutathione content and the activities of its related enzymes were slightly increased in the irradiated group. On the other hand, catalase (CAT) activity was significantly increased by the irradiation. These findings suggested that low-dose irradiation relieved functional disorder in the kidney of mice with ROS-related diseases, probably through enhancing antioxidant, in particular CAT activity. © 2002 Elsevier Science B.V.

    DOI: 10.1016/S0531-5131(02)00151-6

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  • Possible Role of Elevation of Glutathione in Acquisition of Enhanced Immune Function of Mouse Splenocytes Exposed to Low-dose γ-rays 査読

    S. Kojima, S. Matsumori, H. Ishida, M. Takahashi, K. Yamaoka

    Radiation and Homeostasis   1236   491 - 494   2002年7月

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    担当区分:最終著者   記述言語:英語   掲載種別:論文集(書籍)内論文  

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  • Basic study on the radon effects and the thermal effects in radon therapy 査読

    Kiyonori Yamaoka, Takashi Mifune, Shuji Kojima, Shuji Mori, Koichi Shibuya, Yoshiro Tanizaki, Katsuhiko Sugita

    Radiation and Homeostasis   1236   75 - 79   2002年7月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:論文集(書籍)内論文  

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  • 気体状放射性ヨウ素濃度の簡易測定法 査読

    渋谷光一, 山岡聖典, 永松知洋, 花元克己, 川崎祥二, 平木祥夫

    Radioisotopes   51 ( 2 )   16 - 20   2002年4月

  • 低線量放射線の適応応答に関する最近の研究動向とその意義 査読

    楠原俊昌, 花元克己, 山岡聖典

    岡山大学医学部保健学科紀要   13 ( 1 )   7 - 15   2002年3月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(大学,研究機関等紀要)  

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  • 慢性期および急性期病棟におけるアメニテイに関する比較研究 査読

    小野清美, 林優子, 山岡聖典

    日本インテリア学会論文報告集   12   43 - 47   2002年3月

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  • Possible Role of Elevation of Glutathione in Acquisition of Enhanced Immune Function of Mouse Splenocytes Exposed to Low-dose γ-rays 査読

    Shuji Kojima, Shirane Matsumori, Hirokazu Ishida, Mareyuki Takahashi, Kiyonori Yamaoka

    Radiation and Homeostasis, Excerpta Medica   491 - 494   2001年6月

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    担当区分:最終著者   掲載種別:研究論文(研究会,シンポジウム資料等)  

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  • 放射性ヨウ素の空気中濃度測定法の簡便化に向けての基礎的検討 査読

    渋谷光一, 山岡聖典, 永松知洋, 川崎祥二, 平木祥夫

    岡山大学保健学科紀要   11 ( 1 )   35 - 39   2001年3月

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    記述言語:日本語   出版者・発行元:岡山大学医学部保健学科  

    空気中の放射性ヨウ素(125I)の濃度を簡便に測定する為に,活性炭濾紙を装着したホルダを50mlの注射器にセットした簡易な装置を考案・試作した.Nal(T1)ウェルタイプシンチレーションカウンタによって調べた活性炭濾紙での125Iの捕集効率は,44.5%であった.50ml注射器で1lの空気を活性炭濾紙に通し,その放射能とバックグランドをそれぞれ30分間,Nal(T1)ウェルタイプシンチレーションカウンタで測定した場合,空気中濃度限度の2.12倍の濃度であれば測定可能と考えられた.又,活性炭濾紙とプラスチックホルダからの気体状ヨウ素の漏れを防いで捕集効率を94.3%以上に上げることができれば,空気中濃度限度の125Iを測定できると考えられた.したがって,放射性ヨウ素の取り扱い中に,簡便に安価に空気中濃度の異常を検出する方法として有効と考えられた

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    その他リンク: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2000&ichushi_jid=J03360&link_issn=&doc_id=20001127480004&doc_link_id=http%3A%2F%2Fousar.lib.okayama-u.ac.jp%2F11711&url=http%3A%2F%2Fousar.lib.okayama-u.ac.jp%2F11711&type=%89%AA%8ER%91%E5%8Aw%81F%89%AA%8ER%91%E5%8Aw%8Aw%8Fp%90%AC%89%CA%83%8A%83%7C%83W%83g%83%8A&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F80034_3.gif

  • 看護の視点からのアメニティ創出への試み ラッピング技法を用いてのアプローチから 査読

    小野清美, 林優子, 大井伸子, 奥田博之, 山岡聖典

    岡山大学医学部保健学科紀要   12 ( 1 )   27 - 36   2001年3月

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  • 欧州におけるラドン療法の医学的研究に関する最近の動向 査読

    山岡聖典, 御舩尚志

    岡山大学医学部保健学科紀要   12 ( 1 )   7 - 13   2001年3月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(大学,研究機関等紀要)  

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  • Effects of Low-dose Irradiation on the Growth Changes in Culture Cells by Iron 査読

    Kiyonori Yamaoka, Shuji Kojima, Shuji Mori, Koichi Shibuya, Yoshiki Takehara

    Radioisotopes   50 ( 2 )   37 - 42   2001年2月

  • Prevention of type I diabetes by low-dose gamma irradiation in NOD mice 査読

    Mareyuki Takahashi, Shuji Kojima, Kiyonori Yamaoka, Etsuo Niki

    Radiation Research   154 ( 6 )   680 - 685   2000年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:RADIATION RESEARCH SOC  

    Pretreatment with nonlethal, low-dose irradiation has been shown to have a protective effect against oxidative injury in animal tissues, Since oxidative injury of tissues is known to be a major cause of many human diseases, we examined the effect of low-dose irradiation on the progression of type I diabetes in mice, Nonobese diabetic (NOD) mice were treated with gamma irradiation and the progression of the disease was monitored. An elevated level of glucose in urine was first detected at 15 weeks of age in the control NOD mice, whereas the detection was delayed as long as 7 weeks when the mice received a single dose of 0.5 Gy total-body irradiation between 12 and 14 weeks of age. The greatest effect was observed in the mice irradiated at 13 weeks of age, The increase in blood glucose and decrease in blood insulin were effectively suppressed by irradiation at 13 weeks of age. Both suppression of cell death by apoptosis and an increase in superoxide dismutase (SOD) activity were observed in the pancreas 1 week after irradiation. The results indicate that treatment with 0.5 Gy gamma rays suppresses progression of type I diabetes in NOD mice. This is the first report on the preventive effect of low-dose irradiation on disease progression. (C) 2000 by Radiation Research Society.

    DOI: 10.1667/0033-7587(2000)154[0680:POTIDB]2.0.CO;2

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  • Involvement of calcium ion in elevation of mRNA for γ-glutamylcysteine synthetase (γ-GCS) induced by low-dose gamma-rays 査読

    K Teshima, A Yamamoto, K Yamaoka, Y Honda, S Honda, T Sasaki, S Kojima

    International Journal of Radiation Biology   76 ( 12 )   1631 - 1639   2000年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:TAYLOR & FRANCIS LTD  

    Purpose. To investigate the mechanism of the intracellular glutathione elevation induced by low-dose gamma -radiation.
    Materials and methods: RAW 264.7 cells were irradiated with 1-400 cGy gamma -rays. Intracellular total glutathione content was determined by DTNB-recycling assay. Expression of mRNA for intracellular glutathione synthesis-related enzymes with or without treatment with Various inhibitors of second messengers of gene expression were examined by Northern blot analysis.
    Results: Expression of mRNA for gamma -glutamylcysteine synthetase (gamma -GCS), a race-limiting enzyme of the de novo glutathione synthesis pathway, was elevated much more than that of glutathione reductase (GR) mRNA after exposure to 50 cGy gamma -rays. The low-dose gamma -ray-induced gamma -GCS mRNA elevation was abolished by inhibitors of protein kinase C and protein tyrosine kinase, as well as by the calcium ion channel blocker, nifedipine. Calcium-related reagents, such BAPTA/AM and EGTA, chelators of intra- and extracellular Ca2+ respectively, and a Ca2+ ionophore (A23187), also strongly blocked the elevation of gamma -GCS mRNA expression induced by gamma -rays.
    Conclusions: The increase of intracellular glutathione in RAW 264.7 soon after low-dose gamma -ray exposure mainly occurs through the operation of the de novo pathway, following by the induction of gamma -GCS mRNA, for which elevation of intracellular calcium is required.

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  • One-step purification of rabbit histidine rich glycoprotein by dye-ligand affinity chromatography with metal ion requirement 査読

    Shuji Mori, Masahiro Nishibori, Kiyonori Yamaoka, Motoi Okamoto

    Archives of Biochemistry and Biophysics   383 ( 2 )   191 - 196   2000年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A simple method for purification of the histidine rich glycoprotein (rHRG) from rabbit sera was developed. The rHRG was purified by one-step affinity chromatography using the triphenylmethane dye 'acid fuchsin' as a specific ligand, which gave an overall yield above 80%. Interestingly, the binding of rHRG to the ligand required the divalent transition-metal ions such as Zn2+, Ni2+, and Co2+ at pH 9.5. In the presence of 0.5 mM ZnCl2, the binding was enhanced 15 times compared with that in the absence of ZnCl2. Bound rHRG was efficiently eluted from the affinity absorbent with 100 nM imidazole or histidine. Purified rHRG was homogeneous with an M(r) of 94 kDa when analyzed by SDS-PAGE, whereas isoelectric focusing revealed microheterogeniety with pI values ranging from 6.3 to 6.8. Blotting analysis with lectins specific for carbohydrate moieties and treatment with glycosidases demonstrated that rHRG is a highly N-glycosylated protein with diverse carbohydrate structures. (C) 2000 Academic Press.

    DOI: 10.1006/abbi.2000.2032

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  • Suppression of ROS-related disease in mouse models by low-dose γ-ray irradiation 査読

    T. Nomura, K. Sakai, S. Kojima, M. Takahashi, K. Yamaoka

    Biological Effects of Low Dose Radiation   1211   101 - 106   2000年6月

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  • Induction of glutathione in mouse brain by low dose of γ-rays 査読

    S. Kojima, K. Yamaoka

    Biological Effects of Low Dose Radiation   1211   117 - 127   2000年6月

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  • Induction of Endogenous Antioxidant System by Low Dose Radiation and its Applicable Possibility for Treatment of Active Oxygen Species RelatedDiseases 査読

    K.Yamaoka

    Bull Fac. Health Sci., Okayama Univ. Med. Sch.   11 ( 1 )   1 - 15   2000年3月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(大学,研究機関等紀要)  

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  • Induction of Endogenous Antioxidant System by Low Dose Radiation and its Applicable Possibility for Treatment of Active Oxygen Species Related Diseases 査読

    Kiyonori Yamaoka

    Bull Fac. Health Sci., Okayama Univ. Med. Sch.   11 ( 1 )   1 - 15   2000年2月

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    担当区分:筆頭著者, 責任著者   記述言語:英語  

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  • 低線量放射線の不思議な生体作用-ラドン温泉が効くわけを探る- 招待 査読

    山岡聖典, 小島周二

    現代化学   346   24 - 30   2000年1月

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  • Oxygen concentration regulates NO-dependent relaxation of aortic smooth muscles 査読

    Y Takehara, H Nakahara, S Okada, K Yamaoka, K Hamazaki, A Yamazato, M Inoue, K Utsumi

    Free Radical Research   30 ( 4 )   287 - 294   1999年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:HARWOOD ACAD PUBL GMBH  

    Nitric oxide (NO) functions as an endothelium-derived relaxation factor and regulates vascular resistance. Recent studies in this laboratory (Arch. Biochem. Biophys. 323, 27-32, 1995) revealed that the lifetime of NO significantly increased at physiologically low levels of oxygen concentrations and, hence, this gaseous radical strongly inhibited mitochondrial electron transport for a fairly long duration at low oxygen concentrations. The present work describes the effect of oxygen concentration on NO-induced relaxation and guanylate cyclase (GC) activity of endothelium-denuded aorta of the rat. Both NO and 2,2'-(hydroxynitrosohydrazono)bis-ethanamine (NOC18), an NO donor, induced the relaxa-tion of endothelium-denuded helical segments of rat aorta which were contracted by norepinephrine. NO-dependent relaxation of arterial specimens was enhanced by lowering oxygen concentration in the medium with concomitant increase in their cGMP levels. Anoxia induced the relaxation of the aorta by some NO-enhanceable and methylene blue-insensitive mechanism. These results suggested that local concentrations of oxygen might play important roles in the regulation of NO-dependent GC activity and vascular tonus of resistance arteries.

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  • 低線量放射線に対する生体の応答反応-抗酸化系の誘導とその疾患治療への応用の可能性- 査読

    小島周二, 山岡聖典

    衛生化学   45 ( 3 )   133 - 143   1999年6月

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  • 放射線管理区域における作業環境測定の合理化の検討-表面汚染と空気汚染の関係に着目して- 査読

    山岡聖典, 渋谷光一, 永松知洋, 川崎祥二

    岡山大学医学部保健学科紀要   10 ( 1 )   1 - 13   1999年3月

  • Elevation of antioxidant potency in the brain of mice by low-dose gamma-ray irradiation and its effect on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced brain damage 査読

    S Kojima, O Matsuki, T Nomura, K Yamaoka, M Takahashi, E Niki

    Free Radical Biology & Medicine   26 ( 3-4 )   388 - 395   1999年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    The elevation of endogenous thiol-related antioxidants and free radical scavenging enzymes in the brain of C57BL/6 female mice after low-dose gamma-ray irradiation and its inhibitory effect on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced brain damage were investigated. The brain level of the reduced form of glutathione (GSH) increased soon after irradiation with 50 cGy of gamma-rays, reached a maximum at 3 h post-treatment, and remained elevated until 12 h. Thioredoxin (TRX) was also transiently increased after irradiation. The activities of free radical scavenging enzymes, including Cu/Zn-superoxide dismutase, catalase and glutathione peroxidase, were significantly induced after irradiation as well. Cerebral malondialdehyde was remarkably elevated by MPTP treatment, and this elevation was suppressed by pre- irradiation (50 cGy). The contents of GSH and TRX were significantly decreased by MPTP treatment in comparison with those of the control group. These reductions both seemed to be attenuated by pre-irradiation with gamma-rays. These results suggest that low-dose gamma-ray irradiation induces endogenous antioxidative potency in the brain of mice and might be effective for the prevention and/or therapy of various reactive oxygen species-related neurodegenerative disorders, such as Parkinson's disease and Alzheimer's disease. (C) 1998 Elsevier Science Inc.

    DOI: 10.1016/S0891-5849(98)00200-7

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  • Localization of glutathione and induction of glutathione synthesis-related proteins in mouse brain by low doses of gamma-rays 査読

    S Kojima, O Matsuki, T Nomura, N Shimura, A Kubodera, K Yamaoka, H Tanooka, H Wakasugi, Y Honda, S Honda, T Sasaki

    Brain Research   808 ( 2 )   262 - 269   1998年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    First, we determined the cerebral localization of reduced glutathione (GSH) in normal mice by means of autoradiography using Tc-99m-meso-hexamethyl propylene oxime. A highly specific localization of GSH in the cerebellum and hippocampus was observed. Secondly, we measured the elevation of GSH level in the brain after low-dose gamma-irradiation. The cerebral GSH levels increased soon after irradiation with 50 cGy of gamma-rays, reaching a maximum at 3 h post-treatment, then remaining significantly higher than that of the non-irradiated control until 12 h and returning to the control level by 24 h. Thirdly, we examined the induction of the activities and the mRNAs of proteins involved in the synthesis and regeneration of GSH in the brain of mice subjected to low-dose gamma-ray irradiation. The level of mRNA for gamma-glutamylcysteine synthetase was significantly increased at 0.5 h, and remained high until 2 h post-irradiation (50 cGy). The level was transiently lowered to the non-irradiated control level at 3 h and slightly increased again after 6 h post-irradiation. gamma-Glutamylcysteine synthetase activity was significantly increased 3 h after irradiation, and remained high up to 24 h post-irradiation. As for glutathione reductase, the mRNA level was increased at 0.5 h, and peaked strongly at 2 h, while the enzyme activity was significantly increased at 6 h after irradiation, and continued to increase up to 24 h. The level of mRNA for thioredoxin, which contributes to GSH biosynthesis by supplying cysteine to the de novo pathway, peaked between 0.5 h and 2 h post-irradiation, and rapidly declined thereafter. The content of thioredoxin showed a transient decrease immediately after irradiation, but was then remarkably elevated, reaching a maximum at 3 h, and thereafter declining sharply. These results indicate that the increase in endogenous GSH in mouse brain soon after low-dose gamma-ray irradiation is a consequence of the induction of GSH synthesis related proteins and occurs via both the de novo synthesis and the regeneration pathways. (C) 1998 Elsevier Science B,V, All rights reserved.

    DOI: 10.1016/S0006-8993(98)00832-4

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  • バードガスタインにおけるラドン療法とその機構解明 招待 査読

    山岡聖典

    Radioisotopes   47 ( 9 )   59 - 60   1998年9月

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    担当区分:責任著者   掲載種別:研究論文(学術雑誌)  

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  • 小線量γ線のマウス生体内抗酸化系酵素活性に対する作用 査読

    松木 修, 野村崇治, 小島周二, 久保寺昭子, 山岡聖典

    Radioisotopes   47 ( 4 )   291 - 299   1998年4月

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  • Influence of Low-dose X-irradiation on Cell Membrane Fluidity of Human Fibroblast 査読

    Keiichiro Ishii, Kiyonori Yamaoka

    Lipid Peroxide Research   21 ( 2 )   96 - 97   1997年10月

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  • Cold-Stress Induces Thymocyte Apoptosis in the Rat 査読

    S.Morishita, Y.Nishi, E.F.Sato, K.Yamaoka, M.Manabe, M.Inoue

    Pathophysiology   47 ( 3 )   213 - 219   1997年3月

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    掲載種別:研究論文(学術雑誌)  

    Although various stresses have been known to induce atrophy of the thymus, its pathogenesis remains to be clarified. To elucidate the mechanism of stress-induced atrophy of the thymus, possible involvement of thymocyte apoptosis was studied using rats which were exposed to cold environment. Exposure to cold temperature (5°C) for 4 h induced the fragmentation of thymocyte DNA in fasted rats but not in fed animals. Glucose levels in the blood and the body temperature of both fasted and fed rats markedly decreased during the exposure to cold temperature. Cold-stress significantly increased the plasma levels of corticosterone in fasted rats by some mechanism which was suppressed by feeding. The cold-stress-induced apoptosis was inhibited by either adrenalectomy or administration of RU486, a glucocorticoid receptor antagonist. Administration of glucose (7.5 g/kg body weight) also prevented the stress-induced apoptosis of thymocytes. These results suggested that cold-stress might enhance the secretion of glucocorticoid from the adrenal gland and induce apoptosis of thymocytes by some glucose-inhibitable mechanism.

    DOI: 10.1016/S0928-4680(97)00021-7

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  • 低線量放射線照射による化学的生体防御機構の活性化とその効果に関する研究 査読

    山岡聖典

    電力中央研究所総合報告   T46   1996年10月

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  • Low Dose X-ray Irradiation Induces Stress Proteins but does not Prevent Gastric Mucosal Lesion 査読

    E.F.Sato, K.Yamaoka, H.Yu, S.Morishita, M.Inoue

    Physiological Chemistry & Physics and Medical NMR   28 ( 2 )   103 - 109   1996年4月

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    掲載種別:研究論文(学術雑誌)  

    We studied the effect of low dose X-ray irradiation on the expression of stress proteins and gastric mucosal lesion. Low X-ray irradiation induced the expression of mRNA for heme oxygenase in adrenal and stomach. The expression hsp70 mRNA was also induced by low dose X-ray irradiation in the adrenal gland but not in the stomach. However, the expression of Mn-SOD mRNA was not changed in either tissue by low dose X-ray irradiation. Nor was WIR stress-induced gastric mucosal lesion prevented by pre-irradiation. These data suggest that low dose X-ray irradiation induced stress proteins in some specific tissues only. It did not prevent the gastric mucosal lesion.

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  • 分子生物学からのメッセージ:プリン・ピリミジン代謝系 招待

    入山啓治, 小幡徹, 石岡憲昭, 山岡聖典

    化学工業   47 ( 4 )   69 - 79   1996年4月

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  • 進む放射線ホルミシスの解明 招待 査読

    山岡聖典, 石田健二

    OHM   83 ( 4 )   84 - 88   1996年4月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • Study on Effects of Vitamin E and Low-dose X-irradiation on Lipid Peroxides in Cells 査読

    K.Yamaoka, K.Ishii

    Lipid Peroxide Research   19 ( 2 )   90 - 92   1995年7月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • Effect of low-dose X-ray irradiation on membrane fluidity of human fibroblasts 査読

    K.Ishii, K.Yamaoka

    Lipid Peroxide Research   19 ( 2 )   96 - 98   1995年7月

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  • Protection against Alloxan Diabetes by Low-dose 60Co γ Irradiation before Alloxan Administration 査読

    Y.Takehara, K.Yamaoka, Y.Hiraki, T.Yoshioka, K.Utsumi

    Physiological Chemistry & Physics and Medical NMR   27 ( 3 )   149 - 159   1995年6月

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    掲載種別:研究論文(学術雑誌)  

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  • Enhanced Mitogen-induced Prolification of Rat Splenocytes by Low-dose Whole-body X-irradiation 査読

    K.Ishii, K.Yamaoka, Y.Hosoi, T.Ono, K.Sakamoto

    Physiological Chemistry & Physics and Medical NMR   27 ( 1 )   17 - 23   1995年2月

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    掲載種別:研究論文(学術雑誌)  

    To elucidate the stimulative effect on the immune system, we studied the effect of acute low-dose whole-body X-irradiation on the mitogen-induced proliferative responses of rat splenocytes and thymocytes. Concanavalin A (Con A)-induced mitogen response of rat splenocytes 4 hours after 5 cGy irradiation was significantly higher (by 80%, p < 0.02) than that in sham-irradiated controls; whereas that of rat thymocytes did not show change after irradiation of 1-10 cGy. In the rats X-irradiated with doses greater than 25 cGy, Con A-induced mitogen responses of splenocytes and thymocytes were reduced. In a way similar to the Con A-induced mitogen response of splenocytes, the mitogen response of splenocytes induced by phytohemagglutinin (PHA) or lipopolysaccharide (LPS) was significantly increased by X-irradiation with 5 cGy (by 50%, p < 0.02). The enhancement of mitogen response of splenocytes was observed within a few hours after irradiation, being a temporary effect. After 5 cGy irradiation the level of leukotriene B4 (LTB4) in the supernatant fraction of the splenocyte suspension showed a significant increase (by 40%, p < 0.05).

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  • 低線量γ線照射によるアロキサン糖尿病症状の抑制効果 査読

    山岡聖典, 竹原良記, 吉岡保, 内海耕慥

    電力中央研究所研究報告   T94004   1994年10月

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  • ラドン泉吸入によるウサギ脳内の生体アミンの変化 査読

    山岡聖典, 古元嘉昭, 鈴鹿伊智雄, 枝松礼, 森 昭胤

    過酸化脂質研究   18 ( 2 )   201 - 204   1994年10月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • DNA Damage by Various Forms of Active Oxygens and its Inhibition by Different Scavengers using Plasmid DNA 査読

    Y.Takehara, K.Yamaoka, E.F.Sato, T.Yoshioka, K.Utsumi

    Physiological Chemistry & Physics and Medical NMR   26 ( 3 )   215 - 226   1994年6月

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  • 低線量X線照射がラット細胞膜の構造および輸送に及ぼす作用 査読

    山岡聖典, 枝松礼, 伊藤武彦, 森昭胤

    電力中央研究所研究報告   T93006   1994年4月

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    担当区分:筆頭著者, 責任著者   記述言語:英語  

    DOI: 10.1016/0891-5849(94)90132-5

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  • 低線量放射線が生体機能に及ぼす影響に関する研究 査読

    山岡聖典

    電力中央研究所総合報告   T34   1994年4月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • Changes in Biogenic Amine Neurotransmitters in Rabbits Brain by Inhalation of Radon Spring 査読

    K.Yamaoka, K.Ishii, T.Ito, Y.Komoto, I.Suzuka, R.Edamatsu, A.Mori

    Neurosciences   20 ( 1 )   17 - 22   1994年2月

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    担当区分:筆頭著者  

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  • ラドン泉吸入の生体機能に及ぼす影響ー家兎における過酸化脂質量とSOD活性― 査読

    山岡聖典, 古元嘉昭, 鈴鹿伊智雄, 枝松礼, 森 昭胤

    過酸化脂質研究   17 ( 3 )   271 - 273   1993年10月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

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  • 遺伝子解析による活性酸素代謝系蛋白測定法の確立とその適用 査読

    山岡聖典, 佐藤英介, 井上正康

    電力中央研究所研究報告   T93055   1993年5月

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    担当区分:筆頭著者, 責任著者  

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  • 活性酸素消去酵素によるDNA損傷の抑制 査読

    山岡聖典, 竹原良記, 佐藤英介, 渡部嘉哉, 吉岡保, 内海耕慥

    電力中央研究所研究報告   T92071   1993年4月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(大学,研究機関等紀要)  

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  • 老齢ラットに及ぼす低線量X線照射の老化抑制効果の検討 査読

    山岡聖典, 枝松礼, 森昭胤

    電力中央研究所研究報告   T92013   1992年12月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(大学,研究機関等紀要)  

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  • Effects of Low Dose X-ray Irradiation on Old Rats -SOD activity, Lipid Peroxide Level, and Membrane Fluidity- 査読

    K.Yamaoka, R.Edamatu, A.Mori

    Low Dose Irradiation and Biological Defense Mechanisms   419 - 422   1992年12月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:論文集(書籍)内論文  

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  • Effects of Inhalation of Radon Spring Water on Biological Functions and Neuronal transmission System 査読

    K.Yamaoka, K.Ishii, Y.Komoto, I.Suzuka, R.Edamatsu, A.Mori

    Oxygen Radicals   773 - 780   1992年10月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:論文集(書籍)内論文  

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  • 低線量照射によるSOD活性増加の機構解明-SODの誘導合成の確認- 査読

    山岡聖典, 佐藤英介, 秋丸国広, 枝重圭祐, 高橋正彦, 内海耕慥

    電力中央研究所研究報告   T91047   1992年5月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(大学,研究機関等紀要)  

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  • 低線量の放射線照射による高血圧改善の基礎検討-高血圧ラットに対するHB-SODの降圧作用- 査読

    山岡聖典, 中園光一, 渡辺信和, 井上正康

    電力中央研究所研究報告   T91042   1992年5月

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  • Possible Interferenceof Low Molecular Compound within a Measurement of SOD Activity using Electron Spin Resonance 査読

    R.Edamatsu, K.Yamaoka, A.Mori

    Magnetic Resonance in Medicine   3   126 - 128   1992年5月

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    掲載種別:研究論文(学術雑誌)  

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  • ESR法によるSOD比活性測定時における低分子化合物の影響 査読

    枝松礼, 山岡聖典, 森昭胤

    磁気共鳴と医学   3   75 - 82   1992年5月

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    掲載種別:研究論文(学術雑誌)  

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  • 低線量放射線照射による生体機能活性-細胞膜の流動性の亢進- 査読

    山岡聖典, 枝松礼, 石井敬一郎, 森昭胤

    電力中央研究所研究報告   T91005   1991年11月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(大学,研究機関等紀要)  

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  • Adrenal Secretion of Catecholamines by Inhalation of Radon Water in Relation to Increase of Tissue 査読

    I.Suzuka, K.Yamaoka, Y.Komoto

    Journal of Japanese College of Angiology   31   1182 - 1187   1991年9月

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    掲載種別:研究論文(学術雑誌)  

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  • 低線量の放射線照射による過酸化脂質量減少の機構解明-生体膜の脂質過酸化反応に対するSODの作用- 査読

    山岡聖典, 岡添陽子, 秋丸国広, 佐藤英介, 内海耕慥

    電力中央研究所研究報告   T90060   1991年6月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(大学,研究機関等紀要)  

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  • ラドン泉吸入による組織の循環促進と過酸化脂質量減少の効果 査読

    山岡聖典, 鈴鹿伊智雄, 宮地幸久, 森昭胤, 枝松礼, 古元嘉昭

    電力中央研究所研究報告   T90007   1990年10月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(大学,研究機関等紀要)  

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  • 放射線ホルミシス 査読

    服部禎男, 根本和泰, 石田健二, 御園生淳, 菅沼浩敏, 石井敬一郎, 山岡聖典

    日本原子力学会誌   32 ( 7 )   688 - 696   1990年7月

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    担当区分:最終著者   掲載種別:研究論文(学術雑誌)  

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  • 低線量照射による生体機能活性-SOD活性増加と過酸化脂質量減少の効果- 査読

    山岡聖典, 枝松礼, 森昭胤

    電力中央研究所研究報告   T89063   1990年5月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(大学,研究機関等紀要)  

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  • 低線量放射線照射が生体機能に及ぼす影響の基礎的検討-ラットの免疫器官におけるSOD活性と血液像の変化について- 査読

    山岡聖典, 金子一郎, 水谷武夫, 中野和城, 枝松礼, 森昭胤

    電力中央研究所研究報告   T89002   1989年6月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(大学,研究機関等紀要)  

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  • 低レベル廃棄物の分別管理システムに関する検討(第1報) 査読

    山岡聖典, 根本和泰, 尾崎幸男, 讃井敏光

    電力中央研究所研究報告   A84010   1985年5月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(大学,研究機関等紀要)  

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  • 紫外部チェレンコフ光による使用済燃料集合体の確認法 査読

    中岡章, 山岡聖典, 栗原雅幸, 福島政法

    電力中央研究所研究報告   A83003   1983年4月

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    掲載種別:研究論文(大学,研究機関等紀要)  

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▼全件表示

書籍等出版物

  • 教科書 改訂版:環境と健康を科学する

    山岡聖典( 担当: 単著)

    健康新聞社(東京)  2017年3月  ( ISBN:9784882698524

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  • Neuropathic Pain

    Takahiro Kataoka, Norie Kanzaki, Kaori Sasaoka, Kiyonori Yamaoka( 担当: 共著 ,  範囲: Mitigating effects of radon inhalation on neuropathic pain in mice and its possible application in veterinary care)

    Avid Science  2016年 

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  • Free Radicals and Health

    Kaori Sasaoka, Takahiro Kataoka, Norie Kanzaki, Kiyonori Yamaoka( 担当: 共著 ,  範囲: Possible applications of radon therapy in veterinary care for oxidative stress-induced kidney damage)

    Nova Science Publishers  2016年  ( ISBN:9781536101

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  • Radon: Geology, Environmental Impact and Toxicity Concerns

    Takahiro Kataoka, Akihiro Sakoda, Reo Etani, Yuu Ishimori, Fumihiro Mitsunobu, Kiyonori, Yamaoka( 担当: 共著 ,  範囲: The possible applications of radon inhalation treatment as antioxidant therapy for hepatopathy)

    Nova Science Publishers  2015年 

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  • 放射能泉の安全に関するガイドブック

    山岡聖典( 担当: 共著 ,  範囲: 放射能泉と健康)

    健康と温泉フォーラム(東京)  2012年  ( ISBN:9784990469412

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  • Handbook of Radon: Properties, Applications and Health

    Takahiro Kataoka, Akihiro Sakoda, Yuu Ishimori, Fumihiro Mitsunobu, Kiyonori Yamaoka( 担当: 共著 ,  範囲: Activation of Bio-defense System by Radon Inhalation and its Applicable Possibility for Treatment of Lifestyle Diseases)

    Nova Science Publishers  2012年  ( ISBN:9781621001775

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  • 教科書 放射線実験学

    山岡聖典,花元克巳,川辺 睦,片岡隆浩,迫田晃弘

    岡山大学出版会  2010年9月  ( ISBN:9784904228159

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  • 研究者たちの発信

    山岡聖典他

    to be 出版  2008年11月  ( ISBN:9784990269586

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  • 大自然の三大健康浴-森林浴・温泉浴・岩盤浴-

    山岡聖典

    健康新聞社(東京)  2008年4月 

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  • 教科書 環境と健康を科学する

    山岡聖典( 担当: 単著)

    健康新聞社(東京)  2005年4月  ( ISBN:4882695774

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    総ページ数:175   記述言語:日本語

    CiNii Books

    ASIN

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  • 低線量放射線影響-疫学と放射線生物学の接点を求めて-

    山岡聖典他

    日本工業新聞社  2004年 

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  • 遠赤外線とマイナスイオンの科学と展望

    金宗哲, 山岡聖典, 韓忠珠, 佐野洋, 金振寥

    日本遠赤外線応用研究会・韓国遠赤外線協会  2004年 

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  • 低線量放射線の健康影響ーがんリスクはあるか?ー

    山岡聖典( 担当: 共著 ,  範囲: ラドン温泉の適応症とその機構)

    電気新聞特別号  2003年12月 

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  • Radon und Gesundheit

    K.Yamaoka, S.Hattori, P.Deetjen, A.Falkenbach( 担当: 共著)

    Peter Lang GmbH (Frankfurt)  1999年9月 

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  • Bioradicals

    K.Yamaoka, T.Obata, H.Kamada, H.Ohya( 担当: 共著)

    Yamagata Technopolis Foundation  1998年6月 

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  • Radon and Thoron in the Human Environment

    K.Yamaoka, Y.Komoto, A.Katase, M.Shimo( 担当: 共著)

    Tohwa University  1998年3月 

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  • Health Effects of Low Dose of Ionizing Radiation

    S.Kojima, O.Matuki, K.Yamaoka( 担当: 共著)

    Internationa Atomic Energy Agency  1997年11月 

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  • フリーラジカルの臨床

    近藤元治, 浅田浩二, 岡田茂, 小川紀雄, 山岡聖典

    日本医学館  1996年12月 

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  • 放医研シンポジウムシリーズ No.27:活性酸素・フリーラジカル研究の新展開ー基礎から臨床までー

    山岡聖典( 担当: 共著 ,  範囲: 生体防御機構)

    放射線医学総合研究所  1996年9月 

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  • 放射線ホルミシスⅡ-ヒトおよび動物のデータを中心に-

    松平寛通, 石井敬一郎, 大山ハルミ, 栗原靖之, 佐藤温吉郎, 佐藤鐡也, 色田幹雄, 藤井由布, 古野育子, 御園生 淳, 宮地幸久, 山岡聖典, 山田武

    ソフトサイエンス社  1993年7月  ( ISBN:4881710486

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  • 新学習指導要領に基づく高等学校教科書のエネルギー・環境・原子力・放射線関連記述に関する調査と提言-地理歴史,公民,理科および工業の調査-

    日本原子力学会教育委員会教科書調査担当者, 教育委員会委員

    日本原子力学会  2023年8月 

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  • 新学習指導要領に基づく高等学校教科書のエネルギー・環境・原子力・放射線関連記述に関する調査と提言-地理歴史,公民,理科,保健体育,家庭および工業の調査-

    日本原子力学会教育委員会教科書調査担当者, 教育委員会委員

    日本原子力学会  2022年7月 

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  • 極微量ウラン影響効果試験(2)

    石森有, 迫田晃弘, 田中裕史, 光延文裕, 山岡聖典, 片岡隆浩, 恵谷玲央

    JAEA-Research 2016-005  2016年6月 

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  • ミササスタイル

    山岡聖典他( 担当: 共著 ,  範囲: 健康長寿の湯:三朝温泉)

    鳥取県三朝町  2013年7月 

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  • 極微量ウラン影響効果試験(1)

    石森有, 迫田晃弘, 田中裕史, 光延文裕, 山岡聖典, 片岡隆浩, 大和恵子, 西山祐一

    JAEA-Research 2013-005  2013年6月 

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  • トロン浴で健康増進

    山岡聖典

    法研(東京)  2011年9月 

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  • 教科書 RI実験の手引き 第3版

    山岡聖典, 澁谷光一, 花元克巳, 川辺睦, 迫田晃弘, 水口優子

    岡山大学医学部保健学科編  2007年4月 

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  • トロンで健康ライフ

    山岡聖典

    法研(東京)  2006年 

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  • 自然と健康

    山岡聖典他

    日本ジャーナル出版  2002年 

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  • 放射線と健康

    山岡聖典他

    放射線と健康を考える会  2001年 

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  • 電中研レビュー:放射線ホルミシス 研究の意義と取り組み

    石田健二, 山岡聖典他

    電力中央研究所  1996年3月 

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  • Magnetic Resonance in Medicine

    R.Edamatu, K.Yamaoka, A.Mori( 担当: 共著 ,  範囲: Possible Interference of Low Molecular Compound within a Measurement of SOD Activity using Electron Spin Resonance)

    Society of Magnetic Resonance in Medicine  1990年5月 

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▼全件表示

MISC

  • 理事会だより:支部活動のコロナ禍後の対応と今日的意義の実現

    山岡聖典

    日本原子力学会ホームページ   2024年2月

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    担当区分:責任著者   掲載種別:記事・総説・解説・論説等(学術雑誌)  

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  • 報告:ラドン温泉が三朝町民の健康に及ぼす効果に関するアン ケート調査結果

    山岡聖典, 片岡隆浩

    広報みささ(鳥取県三朝町広報誌)   806   7 - 7   2024年2月

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    担当区分:責任著者   掲載種別:記事・総説・解説・論説等(その他)  

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  • 理事会だより:支部活動の課題と今後の方向性

    山岡聖典

    日本原子力学会誌   65 ( 4 )   59 - 59   2023年4月

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    担当区分:責任著者   掲載種別:記事・総説・解説・論説等(学術雑誌)  

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  • 理事会だより:支部活動の今後の在り方を考える

    山岡聖典

    日本原子力学会誌   64 ( 4 )   54 - 54   2022年4月

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    担当区分:責任著者   掲載種別:記事・総説・解説・論説等(学術雑誌)  

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  • 巻頭言 改めて放射線教育と研究の重要性を考える 招待

    山岡聖典

    鹿田施設ニュース(岡山大学)   14   1 - 1   2021年3月

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    担当区分:責任著者   掲載種別:記事・総説・解説・論説等(大学・研究所紀要)  

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  • コロナ感染症と低線量放射線 招待

    山岡聖典

    月刊エネルギーレビュー誌   40 ( 9 )   3 - 3   2020年9月

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    担当区分:責任著者  

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  • 放射線は微量でも本当に危険,むしろ有益? 招待

    山岡聖典

    岡⼭⼤学医療系キャンパス 魅⼒発信メールマガジン   14   1 - 2   2020年9月

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    担当区分:責任著者   掲載種別:記事・総説・解説・論説等(大学・研究所紀要)  

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  • 鹿田施設におけるラドン療法の新規適応症の探索とその機構解明 招待

    片岡隆浩, 山岡聖典

    鹿田施設ニュース(岡山大学)   14   5 - 12   2019年12月

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    担当区分:責任著者   掲載種別:記事・総説・解説・論説等(大学・研究所紀要)  

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  • 特別寄稿 低線量放射線の健康効果を科学する-ラドン療法を中心に-③ 招待

    山岡聖典

    JAPI Newsletter   19 ( 6 )   2 - 4   2017年1月

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    担当区分:責任著者   掲載種別:記事・総説・解説・論説等(学術雑誌)  

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  • 特別寄稿 低線量放射線の健康効果を科学する-ラドン療法を中心に-② 招待

    山岡聖典

    JAPI Newsletter   19 ( 5 )   2 - 5   2016年11月

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    担当区分:責任著者   掲載種別:記事・総説・解説・論説等(学術雑誌)  

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  • 低線量放射線の健康影響 ラドン温泉の健康効果とそのリスク ラドン療法の適応症に関する機構解明と新規探索 招待

    山岡聖典, 片岡隆浩

    日本放射線影響学会第59回大会ワークショップ講演要旨集   2016年10月

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    担当区分:責任著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)   出版者・発行元:(一社)日本放射線影響学会  

    J-GLOBAL

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  • 特別寄稿 低線量放射線の健康効果を科学する-ラドン療法を中心に-① 招待

    山岡聖典

    JAPI Newsletter   19 ( 4 )   7 - 10   2016年9月

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    担当区分:責任著者   掲載種別:記事・総説・解説・論説等(学術雑誌)  

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  • 低線量放射線の健康影響と医療応用 招待

    山岡聖典

    2015年製薬放射線研修会特別講演抄録集   60 - 91   2015年6月

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    担当区分:責任著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • 低線量放射線と温熱の健康増進効果 招待

    山岡聖典

    Thermal Medicine 誌   30 ( 3 )   71 - 71   2014年9月

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    担当区分:責任著者   記述言語:日本語   出版者・発行元:(一社)日本ハイパーサーミア学会  

    J-GLOBAL

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  • 低線量放射線の健康影響と医療応用 招待

    山岡聖典

    日本アイソトープ協会ライフ サイエンス部会・理工学部会共催エンライトニングセミナー教育講演抄録集   2013年7月

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    担当区分:責任著者   掲載種別:講演資料等(セミナー,チュートリアル,講習,講義他)  

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  • 微量放射線と生体の適応応答 ラドンガスに健康増進の抗酸化力 招待

    山岡聖典

    自然食ニュース誌   475   4 - 17   2013年6月

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    担当区分:責任著者   掲載種別:記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)  

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  • 知らないことによる不幸 招待

    山岡聖典

    月刊エネルギーレビュー誌   33 ( 3 )   3 - 3   2013年3月

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    担当区分:責任著者   掲載種別:記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)  

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  • 特集 放射線を正しく恐れる 低線量放射線の健康への有益効果と医療への応用の可能性 招待

    山岡聖典

    学術の動向(日本学術協力財団)   16 ( 11 )   75 - 79   2011年11月

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    担当区分:責任著者   掲載種別:記事・総説・解説・論説等(学術雑誌)  

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  • 低線量放射線の健康への影響と医療・健康増進への応用の可能性 招待

    山岡聖典

    日本放射線安全管理学会学術第9回大会特別講演予稿集   16 - 16   2010年12月

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    担当区分:責任著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

    J-GLOBAL

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  • 低線量放射線の健康への影響と医療への応用,およびその関連に関する研究 招待

    片岡隆浩, 迫田晃弘, 花元克巳, 川辺 睦, 山岡聖典

    鹿田施設ニュース(岡山大学)   5 ( 1 )   4 - 9   2010年7月

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    担当区分:責任著者   掲載種別:記事・総説・解説・論説等(大学・研究所紀要)  

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  • 生活習慣病に風穴を開ける低線量(少量)放射線 招待

    山岡聖典

    ニューライフ誌   56 ( 10 )   36 - 39   2009年10月

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    担当区分:責任著者   掲載種別:記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)  

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  • 放射線ホルミシスによる健康効果 招待

    山岡聖典

    ニューライフ誌   56 ( 9 )   15 - 18   2009年9月

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    担当区分:責任著者   掲載種別:記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)  

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  • 巻頭言 発展が期待される鹿田施設 招待

    山岡聖典

    鹿田施設ニュース(岡山大学)   4   1 - 1   2009年7月

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    担当区分:責任著者   掲載種別:記事・総説・解説・論説等(大学・研究所紀要)  

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  • 低線量事前照射で脳浮腫が抑制 招待

    山岡聖典, 吉本雅章

    Medical Tribune 誌   42 ( 8 )   44 - 44   2009年2月

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    担当区分:責任著者   掲載種別:記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)  

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  • ラドンによる低線量放射線の医療・ヘルスプロモーション(健康増進)への応用 招待

    山岡聖典

    ヘルスライフビジネス誌   460   13 - 13   2009年2月

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    担当区分:責任著者   掲載種別:記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)  

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  • 低線量ラドンの健康効果を解明する-放射線ホルミシス効果の医療・健康増進への応用の可能性- 招待

    山岡聖典

    未来へげんき((国研)日本原子力研究開発機構広報誌)   10   6 - 7   2008年10月

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    担当区分:責任著者   掲載種別:記事・総説・解説・論説等(大学・研究所紀要)  

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  • ラドン療法とその機構 招待

    山岡聖典

    放射線教育フォーラム2008年度第1回勉強会講演資料   1 - 10   2008年6月

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    担当区分:責任著者   掲載種別:講演資料等(セミナー,チュートリアル,講習,講義他)  

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  • エネルギー・環境 最前線:放射線の不思議な生体作用 招待

    山岡聖典

    エネルギーフォーラム誌   2008年1月

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    担当区分:責任著者   掲載種別:記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)  

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  • 研究紹介 ラドン療法の適応症と機構解明の現状 招待

    山岡聖典

    くらしと放射線(関西電力)   21   14 - 24   2007年10月

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    担当区分:責任著者   掲載種別:記事・総説・解説・論説等(その他)  

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  • ストレスと生体応答:ラドン温泉療法の適応症とその機構 招待

    山岡聖典

    日本ハイパーサーミア学会第22回大会シンポジウム抄録集   21   67 - 67   2005年9月

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    担当区分:責任著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • Simplification of analysis for comparison of radioactive characteristics and its application to some minerals for radon therapy 査読

    K.Hanamoto, K.Yamaoka

    Proceedings of the 6th International Conference on High Levels of Natural Radiation and Radon Areas: Radiation Dose and Health Effects   1276   253 - 255   2005年2月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:ELSEVIER SCIENCE BV  

    To simplify the analysis of the radioactive characteristics of the minerals for the radon therapy, we developed a simple method to calculate the ratio of the uranium series to the thorium series (U/Th) without using activity. The ratios calculated by this method agreed well with the ratios calculated using the activity. We applied this method to some minerals for the radon therapy. As a result, the U/Th&apos;s for the sludge of Misasa, the hokutolite, the mineral of Badgastein, and the two kinds of commercially available minerals were 22, 50, 0.94, 0.26, and 0.20, respectively. (c) 2004 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.ics.2004.09.029

    Web of Science

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  • Effects of radon and thermal therapy on osteoarthritis 査読

    K.Yamaoka, F.Mitsunobu, K.Hanamoto, T.Kataoka, Y.Tanizaki

    Proceedings of the 6th International Conference on High Levels of Natural Radiation and Radon Areas: Radiation Dose and Health Effects   1276   249 - 250   2005年2月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:ELSEVIER SCIENCE BV  

    We examined the temporal changes in antioxidants, immune-, vasoactive- and pain-associated substances in human blood by therapy to elucidate the mechanism of osteoarthritis in which radon therapy is used as a treatment. Results showed that radon inhalation enhanced the antioxidation and immune function, and that the changes in vasoactive and pain-associated substances indicate increases in tissue perfusion brought about by radon therapy. (c) 2004 Published by Elsevier B.V.

    DOI: 10.1016/j.ics.2004.12.013

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  • 低線量放射線による健康への影響と医療への応用 招待

    山岡聖典

    第10回日韓遠赤外線シンポジウム記念大会要旨集   61 - 67   2004年5月

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  • ラドン温泉効果とマイナスイオン効果との関係に関する検討-それぞれの適応症とその機構の相関性- 査読

    山岡聖典, 光延文裕, 花元克巳

    過酸化脂質研究   27 ( 1 )   64 - 64   2003年10月

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  • 低線量放射線の生体影響研究 高バックグラウンド研究から宇宙研究へ 高自然放射線環境の健康影響とその機構 ラドン療法の適応症とその機構解明の現状を中心に 招待

    山岡聖典

    日本放射線影響学会第45回大会ワークショップ講演要旨集   70 - 70   2002年9月

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    担当区分:責任著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)   出版者・発行元:(一社)日本放射線影響学会  

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  • 三朝ラドン温泉適応症の機構に関する検討 招待

    山岡聖典

    放射線と健康を考える会誌   6   2 - 12   2002年9月

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  • 欧州におけるラドン療法の医学的研究の動向 招待

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    放射線と健康を考える会誌   4   2 - 10   2002年3月

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  • 温泉入浴法 招待

    松浦邦雄, 久保田一雄, 山岡聖典

    自然と健康誌   9 ( 1 )   120 - 127   2002年1月

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  • ラドン温泉が効く訳を探る 招待

    山岡聖典

    放射線と健康を考える会誌   2   2 - 13   2001年3月

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  • 原子力最前線-放射線ホルミシス- 招待

    山岡聖典

    Energia(中国電力)   592   30 - 41   2001年

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  • Activation of chemical biological defense mechanisms and remission of vital oxidative injury by low dose radiation 招待 査読

    K.Yamaoka, T.Nomura, S.Kojima

    IRPA (International Radiation Protection Association) -10誌   1 - 10   2000年

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  • Effects of Low Dose X-ray Irradiation on Purine Metabolism and Prostaglandins Production in Mice

    K.Yamaoka, E.Niki, T.Obata, K.Iriyama, M.Takahashi

    Proceedings of 2nd International Conference on Biologicals   63 - 65   1997年10月

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  • Effect of small doses of γ-ray on the glutathione synthesis in mouse, In Low doses of ionization radiation: Biological Effects and Regulatory Control 招待

    S.Kojima, O.Matsuki, T.Nomura, M.Takahashi, K.Yamaoka

    IAEA-TECDOC-976   417 - 420   1997年

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  • 現代医学の最前線 低線量γ線照射で糖尿病発症を抑制 招待

    山岡聖典, 石田健二

    キッセイクール誌   13 ( 5 )   13 - 14   1995年10月

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  • 低線量照射による老化抑制機能の活性化 招待

    山岡聖典

    理工学における同位元素研究発表会パネル討論要旨集   32nd   258 - 261   1995年7月

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  • 放射線ホルミシスの正体に迫る

    山田武, 坂本澄彦, 石田健二, 山岡聖典

    原子力工業誌   39 ( 9 )   8 - 33   1993年9月

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  • 温泉を活用した健康まちづくりシンポジウム

    山岡聖典他

    広報みささ(鳥取県三朝町広報誌)   806   6 - 7   2024年2月

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  • ラドン吸入やX線照射に応答するマ ウス肺の代謝物

    神﨑訓枝, 迫田晃弘, 孫略, 片岡隆浩, 山岡聖典

    2022年度人形峠環境技術センターにおける研究・技術開発成果(JAEA- Review) 2023-049   29 - 31   2024年2月

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  • トロンの安全性と可能性について 招待

    山岡聖典

    Sante Dream 誌   35   3 - 6   2024年1月

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  • プロテオーム解析を用いたLPS 誘発マウス肺炎に対するラドン効果研究

    直江翔太, 片岡隆浩, 田中歩, 宮地孝明, 山岡聖典

    日本原子力学会中国・四国支部第17回研究発表会講演要旨集   2023年12月

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  • ラドン吸入のマウス脳中諸タンパク質への作用に関するプロテオーム解析における部分最小二乗判別分析による検討

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    日本原子力学会中国・四国支部第17回研究発表会講演要旨集   2023年12月

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  • 三朝町住民を対象としたラドン温泉入浴習慣と健康に関する横断研究

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    日本原子力学会中国・四国支部第17回研究発表会講演要旨集   2023年12月

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  • Comprehensive analysis of the effects of radon inhalation on protein expression in mouse brain

    Takahiro Kataoka, Shota Naoe, Ayumi Tanaka, Norie Kanzaki, Akihiro Sakoda, Takaaki Miyaji, Kiyonori Yamaoka

    日本放射線影響学会第66回大会講演要旨集   2023年11月

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  • Combination of thoron inhalation and cyclosporine A administration may inhibit acute colitis in mice

    Shota Naoe, Takahiro Kataoka, Ayumi Tanaka, Norie Kanzaki, Akihiro Sakoda, Kiyonori Yamaoka

    日本放射線影響学会第66回大会講演要旨集   2023年11月

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  • Changes in sulfur metabolism in mouse heart following radon inhalation

    Norie Kanzaki, Akihiro Sakoda, Takahiro Kataoka, Kiyonori Yamaoka

    日本放射線影響学会第66回大会講演要旨集   2023年11月

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  • ラドン吸入がマウス脳中タンパク質に及ぼす作用特性とその生理学的意義に関するプロテオーム解析など用いた基礎検討

    直江翔太, 片岡隆浩, 田中歩, 神﨑訓枝, 迫田晃弘, 宮地孝明, 山岡聖典

    日本放射線影響学会第3回若手放射線影響研究会講演要旨集   2023年9月

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  • ラドン吸入によるマウス脳中タンパク質の変動特性に関するプロテオーム解析を用いた基礎検討

    直江翔太, 片岡隆浩, 田中歩, 神﨑訓枝, 迫田晃弘, 宮地孝明, 山岡聖典

    日本原子力学会2023年秋の大会講演要旨集   2023年9月

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  • Changes in glutathione-related metabolites in mouse lungs following radon inhalation or X-ray irradiation

    Norie Kanzaki, Lue Sun, Akihiro Sakoda, Takahiro Kataoka, Kiyonori Yamaoka

    Proceedings of 17th International Congress of Radiation Research   2023年8月

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  • ラドン吸入がマウス脳中タンパク質の発現に及ぼす作用に関する検討

    片岡隆浩, 直江翔太, 雪峰諒平, 田中歩, 神﨑訓枝, 迫田晃弘, 宮地孝明, 山岡聖典

    第60回アイソトープ・放射線研究発表会要旨集   2023年7月

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    直江翔太, 片岡隆浩, 田中歩, 神﨑訓枝, 迫田晃弘, 山岡聖典

    第60回アイソトープ・放射線研究発表会要旨集   2023年7月

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    第60回アイソトープ・放射線研究発表会要旨集   2023年7月

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    担当区分:責任著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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    片岡隆浩, 土生裕, 田中歩, 直江翔太, 高尾総司, 光延文裕, 賴藤貴志, 山岡聖典

    第76回日本酸化ストレス学会抄録集   76   106 - 106   2023年5月

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    第76回日本酸化ストレス学会抄録集   76   105 - 105   2023年5月

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  • ラドン吸入の濃度と期間によるマウス肺のレドックス状態の変化

    神﨑訓枝, 迫田晃弘, 片岡隆浩, 山岡聖典

    第76回日本酸化ストレス学会学術集会抄録集   76   107 - 107   2023年5月

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    日本原子力学会2023年春の年会講演抄録集   2023年3月

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    直江翔太, 片岡隆浩, 雪峰諒平, 村上海斗, 藤本有希, 宮地孝明, 山岡聖典

    日本原子力学会2023年春の年会講演抄録集   2023年3月

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  • 焦電性結晶表面における発生電圧の算出方法

    花元克巳, 片岡隆浩, 山岡聖典

    第70回応用物理学会春季学術講演会講演予稿集   02-156 - 02-156   2023年3月

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  • 低線量X線照射が強制水泳試験とアルコール投与に伴う酸化ストレス障害に及ぼす作用

    藤本有希, 片岡隆浩, 直江翔太, 村上海斗, 雪峰諒平, 山岡聖典

    日本原子力学会中国・四国支部第16回研究発表会講演要旨集   2022年12月

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    片岡隆浩, 石田毅, 直江翔太, 神﨑訓枝, 迫田晃弘, 田中裕史, 光延文裕, 山岡聖典

    日本原子力学会中国・四国支部第16回研究発表会講演要旨集   2022年12月

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    村上海斗, 片岡隆浩, 直江翔太, 藤本有希, 雪峰諒平, 田中歩, 山岡聖典

    日本原子力学会中国・四国支部第16回研究発表会講演要旨集   2022年12月

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    雪峰諒平, 片岡隆浩, 直江翔太, 村上海斗, 藤本有希, 田中歩, 神﨑訓枝, 迫田晃弘, 宮地孝明, 山岡聖典

    日本原子力学会中国・四国支部第16回研究発表会講演要旨集   2022年12月

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  • トロン吸入またはシクロスポリンA投与による急性マウス大腸炎の抑制効果に関する検討―体重・疾患活動性指数・結腸の長さに及ぼす作用―

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    日本原子力学会中国・四国支部第16回研究発表会講演要旨集   2022年12月

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  • Effects of low-dose X-irradiation on oxidative stress induced by forced swim test in some organs

    Shota Naoe, Takahiro Kataoka, Yuki Fujimoto, Kaito Murakami, Ryohei Yukimine, Ayumi Tanaka, Kiyonori Yamaoka

    日本放射線影響学会第65回大会講演要旨集   2022年9月

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  • Combined inhibitory effects of thoron inhalation and ascorbic acid administration on alcohol-induced hepatopathy in mice

    Takahiro Kataoka, Tsuyoshi Ishida, Shota Naoe, Norie Kanzaki, Akihiro Sakoda, Hiroshi Tanaka, Fumihiro Mitsunobu, Kiyonori Yamaoka

    日本放射線影響学会第65回大会講演要旨集   2022年9月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • Changes in sulfur-related metabolites in mouse lungs following radon inhalation

    Norie Kanzaki, Akihiro Sakoda, Takahiro Kataoka, Kiyonori Yamaoka

    日本放射線影響学会第65回大会講演要旨集   2022年9月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • ラドンの細胞培養用培地における溶解・散逸特性に関する基礎的検討

    村上海斗, 片岡隆浩, 直江翔太, 藤本有希, 雪峰諒平, 神﨑訓枝, 迫田晃弘, 寺東宏明, 山岡聖典

    第59回アイソトープ・放射線研究発表会要旨集   2022年7月

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    担当区分:責任著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • ラドン吸入が正常と関節リウマチマウスのサイトカイン代謝に及ぼす影響に関する比較検討

    直江翔太, 片岡隆浩, 村上海斗, 雪峰諒平, 藤本有希, 神﨑訓枝, 迫田晃弘, 光延文祐, 山岡聖典

    第59回アイソトープ・放射線研究発表会要旨集   2022年7月

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  • プロテオーム解析によるラドン吸入マウス脳の酸化ストレス関連タンパク質の変化特性に関する検討

    雪峰諒平, 片岡隆浩, 直江翔太, 村上海斗, 藤本有希, 神﨑訓枝, 迫田晃弘, 宮地孝明, 山岡聖典

    第59回アイソトープ・放射線研究発表会要旨集   2022年7月

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  • 低線量X線照射と強制水泳試験がマウス各組織に及ぼす酸化ストレスの影響に関する比較検討

    藤本有希, 片岡隆浩, 直江翔太, 村上海斗, 雪峰諒平, 山岡聖典

    第59回アイソトープ・放射線研究発表会要旨集   2022年7月

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    担当区分:最終著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • トロン吸入のアスコルビン酸投与併用による急性アルコール性肝障害の抑制とラドン吸入との比較

    片岡隆浩, 石田 毅, 直江翔太, 神﨑訓枝, 迫田晃弘, 田中裕史, 光延文裕, 山岡聖典

    第75回日本酸化ストレス学会学術集会抄録集   75th (CD-ROM)   2022年5月

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    担当区分:責任著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • ラドン吸入は異なる作用で正常と関節リウマチマウスの免疫機能を調節する

    直江翔太, 片岡隆浩, 村上海斗, 雪峰諒平, 藤本有希, 神﨑訓枝, 迫田晃弘, 光延文裕, 山岡聖典

    第75回日本酸化ストレス学会学術集会抄録集   75th (CD-ROM)   2022年5月

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    担当区分:責任著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

    J-GLOBAL

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  • 焦電性結晶による発生X線の温度変化率効果

    花元克巳, 片岡隆浩, 山岡聖典

    第69回応用物理学会春季学術講演会予稿集   2022年3月

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    担当区分:最終著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • ラドン吸入によるマウス諸臓器中のレドックス状態の変化特性とDNA酸化損傷の抑制効果の濃度・吸入時間依存性の検討

    片岡隆浩, 首藤妃奈, 直江翔太, 矢野準喜, 神﨑訓枝, 迫田晃弘, 花元克巳, 光延文裕, 寺東宏明, 山岡聖典

    日本原子力学会 2022年春の年会講演抄録集   2022   2022年3月

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    担当区分:責任著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

    J-GLOBAL

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  • ラドン吸入による免疫調節機能の亢進効果の基礎検討

    直江翔太, 片岡隆浩, 村上海斗, 雪峰諒平, 藤本有希, 神﨑訓枝, 迫田晃弘, 光延文裕, 山岡聖典

    日本原子力学会2022年春の年会講演抄録集   2022   2022年3月

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    担当区分:責任著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

    J-GLOBAL

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  • 皮膚表面におけるラドンの溶解と拡散

    迫田晃弘, 神﨑訓枝, 田中裕史, 石田毅, 片岡隆浩, 光延文裕, 山岡聖典

    2021年度人形峠環境技術センターにおける研究・技術開発成果(JAEA-Review)   2022-080   27 - 28   2022年

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    担当区分:最終著者   掲載種別:記事・総説・解説・論説等(大学・研究所紀要)  

    DOI: 10.11484/jaea-review-2022-080

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  • メタボローム解析を用いたラドン吸入による肺中グルタチオン関連物質の変化特性

    神﨑訓枝, 迫田晃弘, 片岡隆浩, 光延文裕, 山岡聖典

    2021年度人形峠環境技術センターにおける研究・技術開発成果(JAEA-Review)   2022-080   29 - 32   2022年

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    担当区分:最終著者   掲載種別:記事・総説・解説・論説等(大学・研究所紀要)  

    DOI: 10.11484/jaea-review-2022-080

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  • 正常マウスとリウマチマウスではラドン吸入によるサイトカイン代謝に及ぼす影響は異なる

    直江翔太, 片岡隆浩, 村上海斗, 雪峰諒平, 藤本有希, 神﨑訓枝, 迫田晃弘, 光延文裕, 山岡聖典

    日本原子力学会中国・四国支部第15回研究発表会要旨集   2021年10月

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    担当区分:責任著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • ラドン吸入によるマウス諸臓器中のレドックス状態の変化特性とDNA酸化損傷の抑制効果の検討

    片岡隆浩, 首藤妃奈, 直江翔太, 矢野準喜, 神﨑訓枝, 迫田晃弘, 田中裕史, 花元克巳, 光延文裕, 寺東宏明, 山岡聖典

    日本原子力学会中国・四国支部第15回研究発表会要旨集   2021年10月

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  • Radon inhalation decreases DNA damage induced by oxidative stress in mouse organs via the activation of antioxidative functions

    Takahiro Kataoka, Hina Shuto, NAOE Shota Naoe, Junki Yano, Norie Kanzaki, Akihiro Sakoda, Hiroshi Tanaka, Katsumi Hanamoto, Fumihiro Mitsunobu, Hiroaki Terato, Kiyonori Yamaoka

    日本放射線影響学会第64回大会講演要旨集   2021年9月

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  • Dosimetry of radon progeny deposited on skin in air and thermal water

    Akihiro Sakoda, Yuu Ishimori, Norie Kanzaki, Hiroshi Tanaka, Takahiro Kataoka, Fumihiro Mitsunobu, Kiyonori Yamaoka

    日本放射線影響学会第64回大会講演要旨集   2021年9月

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    担当区分:最終著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

    J-GLOBAL

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  • Basic study on the effects of radon inhalation on the cytokine metabolism in mouse blood

    Shota Naoe, Takahiro Kataoka, Yuki Fujimoto, Kaito Murakami, Ryohei Yukimine, Norie Kanzaki, Akihiro Sakoda, Fumihiro Mitsunobu, Kiyonori Yamaoka

    日本放射線影響学会第64回大会講演要旨集   2021年9月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • Metabolomics Data Analysis in Mouse Organs Following Radon Inhalation Using Machine Learning

    Norie Kanzaki, Akihiro Sakoda, Takahiro Kataoka, Kiyonori Yamaoka

    日本放射線影響学会第64回大会講演要旨集   2021年9月

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    担当区分:最終著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • ラドン吸入によるマウス血中サイトカインの変化特性に関する検討

    直江翔太, 片岡隆浩, 矢野準喜, 首藤妃奈, 神﨑訓枝, 迫田晃弘, 光延文裕, 山岡聖典

    第58回アイソトープ・放射線研究発表会要旨集   2021年7月

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    担当区分:責任著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • ラドン吸入によるマウス諸臓器中のDNA酸化損傷抑制の濃度依存性に関する検討

    増川祐伎, 片岡隆浩, 首藤妃奈, 直江翔太, 矢野準喜, 神﨑訓枝, 迫田晃弘, 田中裕史, 花元克巳, 光延文裕, 寺東宏明, 山岡聖典

    第58回アイソトープ・放射線研究発表会要旨集   2021年7月

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    担当区分:責任著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • ラドン吸入によるマウス臓器中のイオウ関連代謝物の変化-メタボローム解析結果の可視化-

    神﨑訓枝, 迫田晃弘, 片岡隆浩, 田中裕史, 山岡聖典

    第58回アイソトープ・放射線研究発表会要旨集   2021年7月

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    担当区分:最終著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • トロン吸入とアスコルビン酸投与による急性アルコール性マウス肝障害の抑制効果に関する検討

    西微香, 片岡隆浩, 石田毅, 直江翔太, 首藤妃奈, 矢野準喜, 神﨑訓枝, 迫田晃弘, 田中裕史, 光延文裕, 山岡聖典

    第58回アイソトープ・放射線研究発表会要旨集   2021年7月

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    担当区分:責任著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • ラドン吸入によるDNA酸化損傷の抑制効果に関する検討

    片岡隆浩, 神崎訓枝, 迫田晃弘, 首藤妃奈, 矢野準喜, 直江翔太, 田中裕史, 花元克巳, 寺東宏明, 光延文裕, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   74th   2021年5月

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    担当区分:責任著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

    J-GLOBAL

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  • マウスの脳および肝臓中のラドン吸入による硫黄関連代謝物の変化

    神崎訓枝, 迫田晃弘, 片岡隆浩, 田中裕史, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   74th   2021年5月

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    担当区分:最終著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • 焦電性結晶による発生X線の経時変化

    花元克巳, 片岡隆浩, 山岡聖典

    第68回応用物理学会春季学術講演会講演予稿集   2021年3月

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    担当区分:最終著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • Alteration of redox state following radon inhalation depends on the antioxidant capacity of organs

    T. Kataoka, N. Kanzaki, A. Sakoda, H. Shuto, J. Yano, S. Naoe, H. Tanaka, K. Hanamoto, H. Terato, F. Mitsunobu, K. Yamaoka

    Proceeding of 20th Biennial Meeting of Society for Free Radical Research – International   165   56 - 56   2021年3月

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    担当区分:責任著者   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.freeradbiomed.2020.12.424

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  • Low-dose irradiation reduces forced swim test-induced immobility and oxidative stress in mice

    Shota Naoe, Takahiro Kataoka, Hina Shuto, Junki Yano, Tsuyoshi Ishida, Tetsuya Nakada, Keiko Yamato, Katsumi Hanamoto, Takaharu Nomura, Kiyonori Yamaoka

    Proceeding of 20th Biennial Meeting of Society for Free Radical Research – International   165   2021年3月

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  • 空気中または水中の皮膚表面に沈着したラドン子孫核種の線量計算

    迫田晃弘, 神﨑訓枝, 田中裕史, 石森有, 片岡隆浩, 光延文裕, 山岡聖典

    2020年度人形峠環境技術センターにおける研究・技術開発成果(JAEA-Review) 2021-068   37 - 38   2021年

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    担当区分:最終著者   掲載種別:記事・総説・解説・論説等(大学・研究所紀要)  

    DOI: 10.11484/jaea-review-2021-068

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  • ラドン吸入による諸臓器中のレドックス状態の変化特性に関する比較検討

    矢野準喜,片岡隆浩,神﨑訓枝,迫田晃弘,首藤妃奈,直江翔太,田中裕史,花元克巳,寺東宏明,光延文裕,山岡聖典

    日本原子力学会中国・四国支部第14回研究発表会講演要旨集   2020年12月

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    担当区分:責任著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • 低線量X線またはγ線照射による強制水泳誘導の無動時間の抑制効果に関する検討

    首藤妃奈, 片岡隆浩, 矢野準喜, 直江翔太, 石田 毅, 中田哲也, 大和恵子, 花元克巳, 野村崇治, 山岡聖典

    日本原子力学会中国・四国支部第14回研究発表会講演要旨集   2020年12月

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    担当区分:責任著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • 放射線技術科学専攻学生の放射線健康影響に関する知識・意識の基礎調査-学習量による意識の変化-

    片岡隆浩, 直江翔太, 矢野準喜, 首藤妃奈, 山岡聖典

    日本原子力学会中国・四国支部第14回研究発表会講演要旨集   2020年12月

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    担当区分:責任著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • ラドン吸入がマウス脳・肝臓に及ぼす酸化ストレスの変化特性

    片岡隆浩, 神崎訓枝, 迫田晃弘, 首藤妃奈, 矢野準喜, 直江翔太, 石田毅, 田中裕史, 花元克巳, 寺東宏明, 光延文裕, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   73rd   2020年10月

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    担当区分:責任著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

    J-GLOBAL

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  • ラドン子孫核種の皮膚表面への沈着と被ばく線量

    迫田晃弘, 石森有, 神崎訓枝, 田中裕史, 山岡聖典, 片岡隆浩, 光延文裕

    日本放射線影響学会第63回大会講演要旨集   136 - 136   2020年10月

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    記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • ラドン吸入がマウス四肢の浮腫に及ぼす作用に関する基礎的検討

    矢野準喜, 片岡隆浩, 首藤妃奈, 直江翔太, 神崎訓枝, 迫田晃弘, 田中裕史, 光延文裕, 山岡聖典

    日本放射線影響学会第63回大会講演要旨集   86 - 86   2020年10月

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    担当区分:責任著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • ラドン吸入によるマウス諸臓器中のレドックス状態の評価

    片岡隆浩, 神崎訓枝, 迫田晃弘, 首藤妃奈, 矢野準喜, 直江翔太, 石田毅, 田中裕史, 花元克巳, 寺東宏明, 光延文裕, 山岡聖典

    日本放射線影響学会第63回大会講演要旨集   87 - 87   2020年10月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • 機械学習を用いたメタボローム解析によるラドン吸入の生物学的影響データの総合的な解釈

    神崎訓枝, 迫田晃弘, 片岡隆浩, 田中裕史, 山岡聖典

    日本放射線影響学会第63回大会講演要旨集   85 - 85   2020年10月

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    担当区分:最終著者   記述言語:英語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • マウス諸臓器中のレドックス状態の違いはラドン吸入による抗酸化機能の亢進に影響する

    片岡隆浩, 神崎訓枝, 迫田晃弘, 首藤妃奈, 矢野準喜, 直江翔太, 石田毅, 田中裕史, 花元克巳, 寺東宏明, 光延文裕, 山岡聖典

    日本原子力学会2020年秋の大会予稿集   2020年9月

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  • 低線量X線照射による抗酸化機能の亢進が強制水泳誘導無動時間を抑制する

    首藤妃奈, 片岡隆浩, 矢野準喜, 直江翔太, 石田毅, 中田哲也, 大和恵子, 花元克巳, 野村崇治, 山岡聖典

    日本原子力学会2020年春の年会予稿集   2020年3月

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  • LiTaO3単結晶による発生X線の経時変化

    花元克巳, 片岡隆浩, 山岡聖典

    応用物理学会春季学術講演会講演予稿集   67th   2020年3月

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    担当区分:最終著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • マウス諸臓器における過酸化水素の産生量のラドン吸入時間依存性

    片岡隆浩, 神崎訓枝, 迫田晃弘, 首藤妃奈, 矢野準喜, 石田毅, 田中裕史, 花元克巳, 寺東宏明, 光延文裕, 山岡聖典

    日本原子力学会2020年春の年会予稿集   2020年3月

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  • 事前または事後の低線量X線照射による強制水泳試験誘導マウス脳の酸化ストレスの抑制効果とその差異

    首藤妃奈, 片岡隆浩, 矢野準喜, 石田毅, 中田哲也, 大和恵子, 花元克巳, 野村崇治, 山岡聖典

    日本放射線影響学会第62回大会講演要旨集   86 - 86   2019年11月

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    担当区分:責任著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • マウス諸臓器におけるラドン吸入による過酸化水素の産生に伴う酸化ストレスの評価

    片岡隆浩, 神崎訓枝, 迫田晃弘, 石田毅, 首藤妃奈, 矢野準喜, 田中裕史, 花元克巳, 寺東宏明, 光延文裕, 山岡聖典

    日本放射線影響学会第62回大会講演要旨集   117 - 117   2019年11月

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    担当区分:責任著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • ラドン吸入によるマウス脳中のグルタチオン合成に関する機械学習に基づいたメタボローム解析

    神崎訓枝, 迫田晃弘, 田中裕史, 片岡隆浩, 石田毅, 山岡聖典

    日本放射線影響学会第62回大会講演要旨集   85 - 85   2019年11月

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    担当区分:最終著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • 低線量X線によるマウス強制水泳試験の無動時間と脳中の酸化ストレスの抑制効果に関する検討

    首藤妃奈, 片岡隆浩, 矢野準喜, 石田毅, 中田哲也, 大和恵子, 花元克巳, 野村崇治, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   13th   2019年9月

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    担当区分:責任著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • ラドン吸入による抗酸化機能の亢進がマウス諸臓器中の過酸化水素産生に及ぼす作用

    片岡隆浩, 神崎訓枝, 迫田晃弘, 石田毅, 首藤妃奈, 矢野準喜, 田中裕史, 花元克巳, 寺東宏明, 光延文裕, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   13th   2019年9月

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  • 岡山大学医学部放射線技術科学専攻学生の放射線の健康影響に関する知識・意識の基礎調査

    片岡隆浩, 矢野準喜, 首藤妃奈, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   13th   2019年9月

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    担当区分:責任著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • 低線量X線照射によるマウスのうつ病症状に及ぼす作用に関する基礎的検討

    片岡隆浩, 石田毅, 柚木勇人, 大和恵子, 花元克巳, 野村崇治, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   56th   2019年7月

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  • ラドン水の皮脂成分への溶解度とその温度依存性に関する検討

    石田毅, 迫田晃弘, 片岡隆浩, 神崎訓枝, 田中裕史, 柚木勇人, 光延文裕, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   56th   2019年7月

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  • 低線量X線照射がマウスの強制水泳に伴う無動時間に及ぼす影響に関する検討

    片岡隆浩, 石田毅, 柚木勇人, 大和恵子, 花元克巳, 野村崇治, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   72nd   2019年6月

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  • LiTaO3単結晶による発生X線の結晶表面-ターゲット間距離依存性 II

    花元克巳, 片岡隆浩, 山岡聖典

    応用物理学会春季学術講演会講演予稿集   66th   2019年3月

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    担当区分:最終著者  

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  • 機械学習による低線量放射線の生体影響評価

    神崎訓枝, 迫田晃弘, 片岡隆浩, 山岡聖典

    CCSE Workshop   30th   2019年3月

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    担当区分:最終著者   掲載種別:機関テクニカルレポート,技術報告書,プレプリント等  

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  • Radon inhalation has antioxidative effects and suppresses oxidative stress induced damages

    Takahiro Kataoka, Kiyonori Yamaoka

    Proceeding of 9th Annual Meeting of the International Society of Radiation Neurobiology   2019年

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    担当区分:最終著者, 責任著者   掲載種別:研究発表ペーパー・要旨(国際会議)  

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  • Assessment of Radiation Effects using Taguchi Method

    Norie Kanzaki, Akihiro Sakoda, Takahiro Kataoka, Tsuyoshi Ishida, Hiroshi Tanaka, Kiyonori Yamaoka

    Proceeding of 65th Annual Meeting of the Radiation Research Society   2019年

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    担当区分:最終著者   掲載種別:研究発表ペーパー・要旨(国際会議)  

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  • Basic study on suppression effects of active oxygen diseases by radon inhalation and its mechanism

    Takahiro Kataoka, Norie Kanzaki, Akihiro Sakoda, Tsuyoshi Ishida, Hiroshi Tanaka, Katsumi Hanamoto, Hiroaki Terato, Fumihiro Mitsunobu, Kiyonori Yamaoka

    Proceeding of 16th International Congress of Radiation Research   2019年

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  • Effects of low-dose X-irradiation on forced swim stress-induced depression in mice

    Takahiro Kataoka, Tsuyoshi Ishida, Yuto Yunoki, Keiko Yamato, Katsumi Hanamoto, Takaharu Nomura, Kiyonori Yamaoka

    Proceeding of 9th Biennial Meeting of Society for Free Radical Research-Asia   2019年

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  • 焦電性結晶によるX線発生装置の開発-X線発生とギャップ間との関係に関して-

    首藤妃奈, 花元克巳, 片岡隆浩, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   12th   2018年11月

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    担当区分:責任著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • 低線量X線照射とアスコルビン酸投与の併用によるマウス脳中の酸化ストレス緩和に関する基礎的検討

    柚木勇人, 片岡隆浩, 神崎訓枝, 神崎訓枝, 小橋佑介, 石田毅, 花元克巳, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   12th   2018年11月

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    担当区分:責任著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • ラドンの皮脂成分での溶解特性

    石田毅, 迫田晃弘, 片岡隆浩, 神崎訓枝, 田中裕史, 小橋佑介, 柚木勇人, 石森有, 光延文裕, 山岡聖典

    日本放射線影響学会第61回大会講演要旨集   79 - 79   2018年11月

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    担当区分:責任著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)   出版者・発行元:(一社)日本放射線影響学会  

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  • ラドン水の皮膚への作用に関する検討-皮脂諸成分への溶解度とその温度依存性-

    石田毅, 迫田晃弘, 片岡隆浩, 神崎訓枝, 田中裕史, 柚木勇人, 石森有, 光延文裕, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   12   28 - 31   2018年11月

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    担当区分:責任著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • 曖昧な低線量放射線影響の評価に向けた機械学習によるビジュアライズ手法の提案

    神崎訓枝, 迫田晃弘, 片岡隆浩, 山岡聖典

    日本放射線影響学会第61回大会講演要旨集   91 - 91   2018年11月

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    担当区分:責任著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)   出版者・発行元:(一社)日本放射線影響学会  

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  • X線照射によるマウス脳の酸化ストレス状態の変化特性に関する検討

    片岡隆浩, 神崎訓枝, 柚木勇人, 小橋佑介, 石田毅, 花元克巳, 山岡聖典

    日本放射線影響学会第61回大会講演要旨集   78 - 78   2018年11月

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    担当区分:責任著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)   出版者・発行元:(一社)日本放射線影響学会  

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  • ラドンの皮脂成分での溶解特性

    石田 毅, 迫田 晃弘, 片岡 隆浩, 神崎 訓枝, 田中 裕史, 小橋 佑介, 柚木 勇人, 石森 有, 光延 文裕, 山岡 聖典

    日本放射線影響学会大会講演要旨集   61回   79 - 79   2018年11月

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    記述言語:日本語   出版者・発行元:(一社)日本放射線影響学会  

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  • ラドンとトロンの吸入によるマウス諸臓器中の酸化ストレス緩和効果に関する比較検討

    小橋佑介, 片岡隆浩, 神崎訓枝, 神崎訓枝, 迫田晃弘, 田中裕史, 石森有, 光延文裕, 石田毅, 柚木勇人, 山岡聖典

    日本原子力学会2018年秋の大会予稿集   2018年9月

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    担当区分:責任著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • ラドン水の皮膚に及ぼす影響の基礎的検討-皮脂への溶解度-

    石田毅, 迫田晃弘, 片岡隆浩, 神崎訓枝, 田中裕史, 小橋佑介, 柚木勇人, 石森有, 光延文裕, 山岡聖典

    日本原子力学会2018年秋の大会予稿集   2018年9月

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  • ラドン吸入によるマウス腎障害の抑制効果に関する検討

    笹岡香織, 笹岡香織, 片岡隆浩, 神崎訓枝, 神崎訓枝, 小橋佑介, 迫田晃弘, 石森有, 山岡聖典

    日本原子力学会2018年秋の大会予稿集   2018年9月

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  • X線照射がマウス脳に及ぼす酸化ストレスの評価

    片岡隆浩, 神崎訓枝, 笹岡香織, 小橋佑介, 柚木勇人, 石田毅, 花元克巳, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   55th   2018年7月

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    担当区分:責任著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • 酸化ストレス疾患に対するラドン吸入と関連薬剤投与の抑制効果の比較検討

    神崎訓枝, 片岡隆浩, 小橋佑介, 石田毅, 柚木勇人, 迫田晃弘, 石森有, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   55th   2018年7月

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    担当区分:責任著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • X線照射がマウス脳に及ぼす酸化ストレスの線量と経過時間依存性の検討

    片岡隆浩, 神崎訓枝, 笹岡香織, 小橋佑介, 柚木勇人, 石田毅, 花元克巳, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   71st   2018年5月

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  • 機械学習による低線量放射線と関連薬剤の効能比較

    神崎訓枝, 片岡隆浩, 小橋佑介, 石田毅, 柚木勇人, 迫田晃弘, 石森有, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   71st   2018年5月

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  • 低線量放射線がマウス脳に及ぼす酸化ストレスの検討

    片岡隆浩, 神崎訓枝, 笹岡香織, 小橋佑介, 柚木勇人, 石田毅, 花元克巳, 山岡聖典

    日本原子力学会2018年春の年会予稿集   2018年3月

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  • LiTaO3単結晶による発生X線の結晶表面-ターゲット間距離依存性

    花元克巳, 片岡隆浩, 山岡聖典

    応用物理学会春季学術講演会講演予稿集   65th   2018年3月

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  • ラドン療法新規適応症探索のための抗酸化機能などを指標にした機械学習によるデータ解析

    神崎訓枝, 片岡隆浩, 小橋佑介, 石田毅, 柚木勇人, 迫田晃弘, 石森有, 山岡聖典

    日本放射線影響学会第60回大会講演要旨集   112 - 112   2017年10月

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  • ラドンとトロンの吸入による生物学的効果に関する比較検討 小動物用トロン吸入装置の試作と抗酸化機能の比較

    小橋佑介, 片岡隆浩, 神崎訓枝, 迫田晃弘, 田中裕史, 石森有, 光延文裕, 山岡聖典

    日本放射線影響学会第60回大会講演要旨集   112 - 112   2017年10月

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  • ラドン吸入によるマウス脳中のSOD活性の増加の機構とその生物学的意義

    片岡隆浩, 神崎訓枝, 小橋佑介, 柚木勇人, 石田毅, 迫田晃弘, 石森有, 山岡聖典

    日本放射線影響学会第60回大会講演要旨集   165 - 165   2017年10月

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  • 機械学習を用いた低線量放射線による疾患抑制効果に関するデータ解析

    神崎訓枝, 片岡隆浩, 小橋佑介, 柚木勇人, 石田毅, 迫田晃弘, 石森有, 山岡聖典

    日本原子力学会2017年秋の大会予稿集   2017年9月

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  • 改良型自己組織化マップ法による文献データに基づく低線量放射線の健康影響の評価

    神崎訓枝, 片岡隆浩, 小橋佑介, 柚木勇人, 石田毅, 迫田晃弘, 石森有, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   11th   2017年9月

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  • 放射線安全の観点からみたプレガバリンの副作用低減を考慮したラドン療法併用による費用対効果に関する検討

    麓有希, 片岡隆浩, 神崎訓枝, 山岡聖典

    安全工学研究発表会講演予稿集   50th   2017年9月

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  • 小動物用トロン吸入装置の試作とこれを用いたラドンとトロンの吸入効果比較の基礎的検討

    小橋佑介, 片岡隆浩, 神崎訓枝, 迫田晃弘, 田中裕史, 石森有, 光延文裕, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   11th   2017年9月

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  • ラドン吸入によるマウス脳におけるMn-SODの誘導合成機構の検討

    片岡隆浩, 神崎訓枝, 小橋佑介, 柚木勇人, 石田毅, 迫田晃弘, 石森有, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   11th   2017年9月

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  • ラドン吸入によるマウス脳中のMn-SOD活性の増加に伴う疾患・老化の抑制の可能性

    片岡隆浩, 神崎訓枝, 小橋佑介, 柚木勇人, 石田毅, 迫田晃弘, 石森有, 山岡聖典

    日本原子力学会2017年秋の大会予稿集   2017年9月

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  • 低線量放射線による疾患抑制の可能性に関する機械学習を用いた特徴抽出

    神崎訓枝, 片岡隆浩, 笹岡香織, 小橋佑介, 石田毅, 柚木勇人, 迫田晃弘, 石森有, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   54th   2017年7月

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  • ラドンの吸入と飲泉の差異によるアルコール誘導マウス胃粘膜障害の抑制効果の比較検討

    片岡隆浩, 恵谷玲央, 恵谷玲央, 神崎訓枝, 迫田晃弘, 田中裕史, 石森有, 光延文裕, 田口勇仁, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   54th   2017年7月

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  • ラドン吸入によるシスプラチン誘導腎障害の抑制に関するマウス系統差の比較検討

    笹岡香織, 片岡隆浩, 小橋佑介, 神崎訓枝, 迫田晃弘, 石森有, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   54th   2017年7月

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  • 低線量放射線による疾患抑制効果と抗酸化機能の関連についての機械学習を用いた検討

    神崎訓枝, 片岡隆浩, 小橋佑介, 石田毅, 柚木勇人, 迫田晃弘, 石森有, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   70th   2017年6月

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  • ラドンの吸入と飲泉によるアルコール誘導マウス胃粘膜障害の抑制作用の機序に関する比較検討

    片岡隆浩, 恵谷玲央, 恵谷玲央, 神崎訓枝, 迫田晃弘, 田中裕史, 石森有, 光延文裕, 田口勇仁, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   70th   2017年6月

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  • 焦電性結晶によるX線イメージングの可能性

    花元克巳, 片岡隆浩, 山岡聖典

    応用物理学会春季学術講演会講演予稿集   64th   2017年3月

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    担当区分:最終著者   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)  

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  • ラドンの吸入または飲泉によるアルコール誘導マウス胃粘膜障害の抑制効果における抗酸化機能の関与

    片岡隆浩, 恵谷玲央, 神崎訓枝, 迫田晃弘, 田中裕史, 石森有, 光延文裕, 田口勇仁, 山岡聖典

    日本原子力学会2017年春の年会予稿集   2017年3月

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  • ラドン吸入によるシスプラチン誘導マウス腎障害の抑制に関する検討

    笹岡香織, 片岡隆浩, 恵谷玲央, 神崎訓枝, 迫田晃弘, 石森有, 山岡聖典

    日本放射線影響学会第59回大会講演要旨集   13 - 13   2016年10月

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    担当区分:責任著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)   出版者・発行元:(一社)日本放射線影響学会  

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  • 球面SOMを用いたラドン吸入とX線照射による抗酸化機能への影響の比較評価

    神崎訓枝, 片岡隆浩, 恵谷玲央, 笹岡香織, 小橋佑介, 金川明弘, 山岡聖典

    日本放射線影響学会第59回大会講演要旨集   13 - 13   2016年10月

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    担当区分:責任著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)   出版者・発行元:(一社)日本放射線影響学会  

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  • ラドン療法条件の最適化に関する基礎的検討

    片岡隆浩, 恵谷玲央, 神崎訓枝, 笹岡香織, 迫田晃弘, 田中裕史, 石森有, 光延文裕, 山岡聖典

    日本放射線影響学会第59回大会講演要旨集   13 - 13   2016年10月

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    担当区分:責任著者   記述言語:日本語   掲載種別:研究発表ペーパー・要旨(全国大会,その他学術会議)   出版者・発行元:(一社)日本放射線影響学会  

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  • ラドン吸入とプレガバリン投与の併用によるマウス神経障害性疼痛への抑制相加効果

    堀江駿介, 片岡隆浩, 恵谷玲央, 神崎訓枝, 笹岡香織, 小橋佑介, 花元克巳, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   10th   2016年9月

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  • ラドン吸入とX線照射によるマウス肝臓への酸化ストレスの比較検討

    神崎訓枝, 片岡隆浩, 笹岡香織, 小橋佑介, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   10th   2016年9月

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  • ラドン吸入とアスコルビン酸投与による一過性脳虚血に伴う神経細胞障害の抑制効果の比較検討

    片岡隆浩, 神崎訓枝, 笹岡香織, 小橋佑介, 花元克己, 田口勇仁, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   10th   2016年9月

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  • アルコール誘導マウス胃粘膜障害へのラドンの吸入と飲泉による抑制効果の組織・病理学的比較検討

    石田毅, 片岡隆浩, 恵谷玲央, 神崎訓枝, 迫田晃弘, 田中裕史, 石森有, 光延文裕, 田口勇仁, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   10th   2016年9月

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  • マウス肝機能に及ぼす低線量放射線とアルコールの作用に関する比較検討

    神崎訓枝, 片岡隆浩, 恵谷玲央, 笹岡香織, 小橋佑介, 山岡聖典

    日本原子力学会2016年秋の大会予稿集   2016年9月

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  • マウス酸化障害抑制に及ぼすラドン各種摂取方法の比較検討

    片岡隆浩, 恵谷玲央, 神崎訓枝, 笹岡香織, 迫田晃弘, 田中裕史, 小橋佑介, 石森有, 光延文裕, 山岡聖典

    日本原子力学会2016年秋の大会予稿集   2016年9月

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  • 球面SOMを用いた低線量放射線と低用量アルコールによる酸化ストレスの比較検討

    神崎訓枝, 片岡隆浩, 恵谷玲央, 笹岡香織, 小橋佑介, 金川明弘, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   69th   2016年8月

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  • 低線量放射線への適応応答による酸化障害の抑制に関する基礎的研究

    片岡隆浩, 田口勇仁, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   69th   2016年8月

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  • ラドン吸入がシスプラチン誘導マウス腎障害に及ぼす効果

    笹岡香織, 片岡隆浩, 恵谷玲央, 神崎訓枝, 迫田晃弘, 石森有, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   53rd   2016年7月

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  • ラドン吸入とプレガバリン投与の併用はマウス神経障害性疼痛に対し相加効果がある

    片岡隆浩, 堀江駿介, 恵谷玲央, 神崎訓枝, 笹岡香織, 小橋佑介, 花元克巳, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   53rd   2016年7月

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  • 自己組織化マップを用いた低線量放射線によるマウス肝臓への酸化ストレスの評価

    神崎訓枝, 片岡隆浩, 恵谷玲央, 笹岡香織, 金川明弘, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   53rd   2016年7月

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  • 三朝ラドン効果研究の意義と近年の研究動向

    片岡隆浩, 神﨑訓枝, 笹岡香織, 小橋佑介, 迫田晃弘, 田中裕史, 石森有, 光延文裕, 山岡聖典

    第41回中国地区放射線影響研究会要旨集   41th   2016年7月

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  • LiTaO3単結晶による発生X線の平均温度変化率依存性

    花元克巳, 片岡隆浩, 山岡聖典

    応用物理学会春季学術講演会講演予稿集   63rd   2016年3月

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  • 自己組織化マップを用いたラドン吸入による微量酸化ストレスの各種評価

    神崎訓枝, 片岡隆浩, 恵谷玲央, 笹岡香織, 峯田英幸, 金川明弘, 山岡聖典

    日本原子力学会2016年春の年会予稿集   2016年3月

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  • 極微量ウラン影響効果試験(2) 査読

    石森有, 迫田晃弘, 田中裕史, 光延文裕, 山岡聖典, 片岡隆浩, 恵谷玲央

    日本原子力研究開発機構JAEA-Research(Web)   2015 ( 024 )   1 - 41   2016年3月

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  • 一過性虚血に伴うスナネズミ脳細胞障害に対するラドン吸入と抗酸化ビタミン剤摂取による抑制効果の比較検討

    片岡隆浩, 恵谷玲央, 神崎訓枝, 笹岡香織, 小橋佑介, 田口勇仁, 山岡聖典

    日本原子力学会2016年春の年会予稿集   2016年3月

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  • ラドン吸入がリポ多糖経鼻投与に伴う肺中の抗酸化物質に及ぼす効果

    中田哲也, 片岡隆浩, 恵谷玲央, 神崎訓枝, 迫田晃弘, 石森有, 田口勇仁, 山岡聖典

    日本放射線安全管理学会学術大会講演予稿集   14th   2015年12月

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  • ラドン吸入またはアスコルビン酸投与によるスナネズミ一過性脳虚血に伴う細胞障害の抑制に関する検討

    片岡隆浩, 恵谷玲央, 神崎訓枝, 笹岡香織, 堀江駿介, 小橋佑介, 田口勇仁, 山岡聖典

    日本放射線影響学会ワークショップ講演論文集   98 - 99   2015年10月

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  • ラドン温泉における吸入または飲泉による高尿酸血症の抑制効果の比較検討

    恵谷玲央, 片岡隆浩, 神崎訓枝, 迫田晃弘, 田中裕史, 石森有, 光延文裕, 山岡聖典

    日本放射線影響学会ワークショップ講演論文集   86 - 87   2015年10月

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  • 自己組織化マップを用いたラドン吸入による肝臓への酸化ストレスの評価

    神崎訓枝, 片岡隆浩, 恵谷玲央, 笹岡香織, 金川明弘, 山岡聖典

    日本放射線影響学会ワークショップ講演論文集   88 - 89   2015年10月

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  • ラドン温泉における高尿酸血症の抑制効果に関する検討

    恵谷玲央, 片岡隆浩, 神崎訓枝, 迫田晃弘, 田中裕史, 石森有, 光延文裕, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   9th   2015年9月

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  • ラドン吸入によるSOD活性の増加がスナネズミ一過性脳虚血に伴う細胞障害抑制に有効に働く

    片岡隆浩, 恵谷玲央, 神崎訓枝, 笹岡香織, 田口勇仁, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   9th   2015年9月

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  • ラドン吸入によるシスプラチン誘導マウス腎障害の緩和の可能性

    笹岡香織, 片岡隆浩, 恵谷玲央, 神崎訓枝, 迫田晃弘, 石森有, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   9th   2015年9月

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  • 自己組織化マップによるラドン吸入とアルコール摂取の酸化ストレスの比較

    神崎訓枝, 片岡隆浩, 恵谷玲央, 笹岡香織, 金川明弘, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   9th   2015年9月

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  • ラドン吸入によるSOD活性の増加作用に関する分子機序の検討

    片岡隆浩, 恵谷玲央, 神崎訓枝, 中田哲也, 迫田晃弘, 石森有, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   52nd   2015年7月

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  • ラドン吸入によるXOD活性の減少は尿酸値の増加を抑制する

    恵谷玲央, 片岡隆浩, 神崎訓枝, 中田哲也, 迫田晃弘, 田中裕史, 石森有, 光延文裕, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   52nd   2015年7月

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  • ラドン吸入による抗酸化機能の亢進は高尿酸血症の症状緩和に有効に働く

    恵谷玲央, 片岡隆浩, 神崎訓枝, 迫田晃弘, 田中裕史, 石森有, 光延文裕, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   68th   2015年6月

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  • ラドン吸入によるマウス脳中SOD活性の増加とその機構に関する考察

    片岡隆浩, 恵谷玲央, 神崎訓枝, 小橋佑介, 迫田晃弘, 石森有, 光延文裕, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   68th   2015年6月

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  • Study on inhibitory effects of radon inhalation on hyperuricemia in mice

    Reo Etani, Takahiro Kataoka, Norie kanzaki, Akihiro Sakoda, Yuu Ishimori, Takehito Taguchi, Kiyonori Yamaoka

    Proceeding of The 15th International Congress of Radiation Research & 日本放射線影響学会第58回大会   2015年5月

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  • Study on response of antioxidant enzymes in mice organs to radon inhalation

    Takahiro Kataoka, Reo Etani, Norie Kanzaki, Tetsuya Nakada, Akihiro Sakoda, Yuu Ishimori, Kiyonori Yamaoka

    Proceeding of The 15th International Congress of Radiation Research & 日本放射線影響学会第58回大会   2015年5月

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  • Comparative study on oxidative stress effects induced by radon inhalation with alcohol administration in mouse liver

    Norie Kanzaki, Takahiro Kataoka, Reo Etani, Kaori Sasaoka, Shunsuke Horie, Kiyonori Yamaoka

    Proceeding of The 15th International Congress of Radiation Research & 日本放射線影響学会第58回大会   2015年5月

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  • Measurements of radon concentration in mouse blood following radon inhalation

    Yuu Ishimori, Hiroshi Tanaka, Akihiro Sakoda, Takahiro Kataoka, Kiyonori Yamaoka, Fumihiro Mitsunobu

    Proceeding of The 15th International Congress of Radiation Research & 日本放射線影響学会第58回大会   2015年5月

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  • LiTaO3単結晶による発生X線の温度差に対する変化

    花元克巳, 片岡隆浩, 山岡聖典

    応用物理学会2015年春季学術講演会講演予稿集   62nd   2015年3月

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  • トロン温浴で健康寿命をアップ 招待

    山岡聖典

    花巻トロン元気通信   2014年12月

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  • ラドン含有の吸入と飲泉によるマウス1型糖尿病の抑制効果の比較検討

    片岡隆浩, 西山祐一, 迫田晃弘, 恵谷玲央, 神崎訓枝, 田中裕史, 石森有, 光延文裕, 山岡聖典

    日本放射線影響学会第57回大会講演要旨集   159 - 159   2014年9月

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  • ラドン吸入による抗酸化機能の亢進が一過性脳虚血に伴うスナネズミ細胞障害に及ぼす効果

    片岡隆浩, 恵谷玲央, 神崎訓枝, 中田哲也, 田口勇仁, 山岡聖典

    日本放射線影響学会第57回大会講演要旨集   159 - 159   2014年9月

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  • ラドン吸入によるマウス腎障害の抑制効果における抗酸化機能の関与の検討

    恵谷玲央, 片岡隆浩, 西山祐一, 迫田晃弘, 神崎訓枝, 田中裕史, 石森有, 光延文裕, 田口勇仁, 山岡聖典

    日本放射線影響学会第57回大会講演要旨集   136 - 136   2014年9月

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  • ラドン吸入によるSODの活性増加の濃度・吸入時間依存性およびその局在に関する検討

    片岡隆浩, 恵谷玲央, 神崎訓枝, 中田哲也, 迫田晃弘, 田中裕史, 石森有, 光延文裕, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   8th   2014年9月

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  • マウス腎臓におけるラドン吸入による抗酸化機能の亢進と関連疾患抑制の検討

    恵谷玲央, 片岡隆浩, 西山祐一, 西山祐一, 迫田晃弘, 神崎訓枝, 田中裕史, 石森有, 光延文裕, 田口勇仁, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   67th   2014年9月

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  • 極微量放射性物質塗布によるマウス炎症性浮腫の抑制効果

    片岡隆浩, 高田裕司, 恵谷玲央, 西山祐一, 西山祐一, 川辺睦, 花元克己, 神崎訓枝, 中田哲也, 田口勇仁, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   67th   2014年9月

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  • ラドン温泉において糖尿病の抑制に吸入と飲泉はどちらが有効か

    山岡聖典, 片岡隆浩, 西山祐一, 西山祐一, 恵谷玲央, 神崎訓枝, 光延文裕, 石森有, 迫田晃弘, 田中裕史

    日本酸化ストレス学会学術集会抄録集   67th   2014年9月

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  • ラドン吸入と抗酸化ビタミン投与の併用によるアルコール性マウス肝障害の抑制効果に関する検討

    恵谷玲央, 片岡隆浩, 西山祐一, 西山祐一, 高田裕司, 高田裕司, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   8th   2014年9月

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  • スナネズミ一過性脳虚血に伴う神経細胞障害に対するラドン吸入による抑制効果

    片岡隆浩, 恵谷玲央, 高田裕司, 川辺睦, 田口勇仁, 山岡聖典

    第51回アイソトープ・放射線研究発表会要旨集   153 - 153   2014年7月

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  • ラドン吸入によるマウス腎障害の抑制効果とその医療応用の可能性

    恵谷玲央, 片岡隆浩, 高田裕司, 西山祐一, 迫田晃弘, 石森有, 光延文裕, 田口勇仁, 山岡聖典

    第51回アイソトープ・放射線研究発表会要旨集   22 - 22   2014年7月

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  • 低線量放射線の健康影響研究:ラドン吸入による一過性脳虚血に伴う細胞障害の抑制効果

    片岡隆浩, 恵谷玲央, 西山祐一, 高田裕司, 田口勇仁, 山岡聖典

    日本原子力学会2014年春の年会予稿集   2014年3月

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  • ラドン吸入によるマウス炎症性腸疾患の症状緩和に関する検討

    西山祐一, 片岡隆浩, 恵谷玲央, 大和恵子, 高山裕司, 田口勇仁, 山岡聖典

    日本放射線影響学会第56回大会講演要旨集   175 - 175   2013年10月

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  • ラドン吸入によるマウス肝障害の抑制効果とその医療応用の可能性

    片岡隆浩, 西山祐一, 恵谷玲央, 高田裕司, 迫田晃弘, 石森有, 光延文裕, 田口勇仁, 山岡聖典

    日本放射線影響学会第56回大会講演要旨集   145 - 145   2013年10月

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  • ラドン雰囲気におけるマウスの臓器吸収線量の系統的検討

    迫田晃弘, 石森有, 田中裕史, 山岡聖典, 片岡隆浩, 西山祐一, 光延文裕

    日本放射線影響学会第56回大会講演要旨集   188 - 188   2013年10月

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  • マウスへのラドン吸入と抗酸化ビタミン投与による抗酸化作用の比較検討

    片岡隆浩, 西山祐一, 恵谷玲央, 高田裕司, 迫田晃弘, 石森有, 田口勇仁, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   7th   2013年9月

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  • ラジウム・ラドン温泉広域連携による地域活性化:ラジウム・ラドン温泉の健康効果 招待

    山岡聖典

    健康と温泉フォーラム   4 - 5   2013年9月

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  • ラドン吸入によるマウス大腸炎の抑制効果に関する検討

    西山祐一, 片岡隆浩, 大和恵子, 大和恵子, 田口勇仁, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   50th   2013年7月

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  • 極微量放射性クリームがマウス炎症性足浮腫に及ぼす効果に関する検討

    高田裕司, 片岡隆浩, 恵谷玲央, 西山祐一, 大和恵子, 大和恵子, 田口勇仁, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   50th   2013年7月

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  • ラドン吸入と抗酸化ビタミン投与によるマウス肝障害の抑制の相乗効果に関する検討

    恵谷玲央, 片岡隆浩, 西山祐一, 大和恵子, 大和恵子, 高田裕司, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   50th   2013年7月

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  • ラドン吸入によるマウス炎症性腸疾患の抑制効果に関する検討

    西山祐一, 片岡隆浩, 大和恵子, 大和恵子, 田口勇仁, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   66th   2013年6月

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  • ラドン吸入試験におけるマウスの線量評価

    迫田晃弘, 石森有, 田中裕史, 山岡聖典, 片岡隆浩, 西山祐一, 光延文裕

    日本保健物理学会研究発表会講演要旨集   46th   2013年6月

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  • PCXMCにおいて線量計算に影響を与える因子

    川辺睦, 花元克巳, 飯島順, 熊代正行, 熊代正行, 片岡隆浩, 山岡聖典

    日本保健物理学会研究発表会講演要旨集   46th   2013年6月

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  • ラドン吸入によるCCl4誘導マウス肝障害の抑制効果とその医療応用の可能性

    片岡隆浩, 西山祐一, 恵谷玲央, 高田裕司, 豊田晃章, 迫田晃弘, 石森有, 光延文裕, 田口勇仁, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   66th   2013年6月

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  • ラドン吸入による急性アルコール性マウス肝障害の抑制効果に関する検討

    豊田晃章, 片岡隆浩, 西山祐一, 田口勇仁, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   66th   2013年6月

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  • 広範囲な気圧下でのLiTaO3単結晶による発生X線と放出電荷

    花元克巳, 川辺睦, 片岡隆浩, 山岡聖典

    応用物理学会2013年春季学術講演会講演予稿集   60th   2013年3月

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  • 極微量ウラン影響効果試験 査読

    石森有, 迫田晃弘, 田中裕史, 光延文裕, 山岡聖典, 片岡隆浩, 大和恵子, 西山祐一

    日本原子力研究開発機構JAEA-Research(Web)   2013 ( 005 )   1 - 60   2013年3月

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  • 焦電性結晶による小型X線源の開発-低気圧下での電子電流と発生X線-

    花元克巳, 川辺睦, 片岡隆浩, 山岡聖典

    日本放射線安全管理学会学術大会講演予稿集   11th   2012年12月

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  • マウス肝臓・腎臓におけるラドン吸入による抗酸化機能亢進とビタミン作用との比較

    片岡隆浩, 西山祐一, 迫田晃弘, 大和恵子, 森井佑至, 恵谷玲央, 高田裕司, 石森有, 田口勇仁, 山岡聖典

    日本放射線影響学会第55回大会講演要旨集   162 - 162   2012年9月

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  • ラドン吸入によるマウス神経障害性疼痛の予防と緩和の効果に関する検討

    大和恵子, 片岡隆浩, 西山祐一, 花元克巳, 川辺睦, 田口勇仁, 山岡聖典

    日本放射線影響学会第55回大会講演要旨集   162 - 162   2012年9月

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  • ラドン療法によるI型糖尿病の症状緩和に関する一考察

    西山祐一, 片岡隆浩, 迫田晃弘, 大和恵子, 田中裕史, 石森有, 光延文裕, 田口勇仁, 山岡聖典

    日本放射線影響学会第55回大会講演要旨集   162 - 162   2012年9月

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  • 大学院教育でのコースワークとリサーチワーク:低線量放射線環境安全・安心工学研究教育 招待

    山岡聖典

    岡山大学教育開発センター 桃太郎フォーラム   XV   45 - 47   2012年9月

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  • ラドン吸入によるI型糖尿病マウスの抑制効果に関する検討

    西山祐一, 片岡隆浩, 大和恵子, 迫田晃弘, 田中裕史, 石森有, 光延文裕, 田口勇仁, 山岡聖典

    第49回アイソトープ・放射線研究発表会要旨集   119 - 119   2012年7月

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  • ラドン吸入による炎症性疼痛と神経障害性疼痛の緩和効果に関する検討

    大和恵子, 片岡隆浩, 西山祐一, 田口勇仁, 山岡聖典

    第49回アイソトープ・放射線研究発表会要旨集   120 - 120   2012年7月

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  • マウス肝障害に対するラドン吸入とビタミンC・E投与による各抗酸化作用の比較検討

    森井佑至, 片岡隆浩, 西山祐一, 迫田晃弘, 大和恵子, 恵谷玲央, 高田裕司, 石森有, 田口勇仁, 山岡聖典

    第49回アイソトープ・放射線研究発表会要旨集   118 - 118   2012年7月

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  • 極微量ウラン子孫核種の吸入による抗酸化機能の亢進に関するビタミン投与との比較による定量化

    片岡隆浩, 西山祐一, 迫田晃弘, 大和恵子, 恵谷玲央, 高田裕司, 森井佑至, 石森有, 田口勇仁, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   65th   2012年6月

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  • ラドン吸入によるストレプトゾトシン誘導マウス1型糖尿病の抑制効果に関する検討

    西山祐一, 片岡隆浩, 迫田晃弘, 田中裕史, 石森有, 田口勇仁, 光延文裕, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   65th   2012年6月

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  • 広範囲な気圧下でのLiTaO3単結晶による発生X線

    花元克巳, 眞鍋政樹, 川辺睦, 片岡隆浩, 山岡聖典

    応用物理学会学術講演会講演予稿集   73rd   2012年3月

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  • LiTaO3単結晶によるX線発生持続時間の気圧依存性

    花元克巳, 川辺睦, 迫田晃弘, 片岡隆浩, 岡田麻里, 山岡聖典

    応用物理学関係連合講演会講演予稿集   59th   2012年3月

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  • 診断X線装置における設定管電流が入射線量に与える影響

    川辺睦, 花元克巳, 迫田晃弘, 三村秀文, 山田一孝, 岸本海織, 片岡隆浩, 飯島順, 熊代正行, 山岡聖典

    医学物理 Supplement   32 ( 1 )   2012年

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  • 四塩化炭素誘導マウス臓器障害に対するラドンの事前と事後吸入の抑制効果の比較検討

    西山祐一, 片岡隆浩, 寺岡准一, 迫田晃弘, 大和恵子, 石森有, 山岡聖典

    日本放射線影響学会第54回大会講演要旨集   112 - 112   2011年11月

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  • マウスにおけるラドン子孫核種吸入による肺の線量評価

    深尾光佑, 迫田晃弘, 石森有, 片岡隆浩, 花元克巳, 川辺睦, 光延文裕, 山岡聖典

    日本放射線影響学会第54回大会講演要旨集   112 - 112   2011年11月

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  • 焦電性結晶による低線量X線源の開発 発生電圧の定量的評価

    花元克巳, 迫田晃弘, 川辺睦, 片岡隆浩, 山岡聖典

    日本放射線影響学会第54回大会講演要旨集   160 - 160   2011年11月

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  • 四塩化炭素誘導マウス肝障害に対するラドンとアスコルビン酸の各抗酸化作用の比較検討

    寺岡准一, 片岡隆浩, 西山祐一, 森井佑至, 大和恵子, 迫田晃弘, 石森有, 田口勇仁, 山岡聖典

    日本放射線影響学会第54回大会講演要旨集   115 - 115   2011年11月

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  • ヒトと小動物におけるラドン及び子孫核種の吸入による吸収線量

    迫田晃弘, 石森有, 深尾光佑, 片岡隆浩, 花元克巳, 川辺睦, 田中裕史, 光延文裕, 山岡聖典

    日本放射線影響学会第54回大会講演要旨集   132 - 132   2011年11月

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  • ラドン吸入によるマウス炎症性疼痛の緩和効果に関する検討

    大和恵子, 片岡隆浩, 西山祐一, 寺岡准一, 森井佑至, 田口勇仁, 山岡聖典

    日本放射線影響学会第54回大会講演要旨集   115 - 115   2011年11月

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