Updated on 2022/10/01

写真a

 
YAMAOKA Kiyonori
 
Organization
Faculty of Health Sciences Professor
Position
Professor
Contact information
メールアドレス
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Degree

  • Doctor of Science ( Waseda University )

  • Doctor of Medicine ( Okayama University )

Research Interests

  • 放射線防護学

  • 健康長寿科学

  • 放射線健康科学

  • 酸化ストレス

  • 生体防御機能

  • 生体応答解析学

  • 安全安心科学

Research Areas

  • Life Science / Radiological sciences

  • Life Science / Hygiene and public health (laboratory)

  • Environmental Science/Agriculture Science / Chemical substance influence on environment

  • Environmental Science/Agriculture Science / Radiation influence

Research History

  • 岡山大学学術研究院特任教授・名誉教授

    2021.4

  • 岡山大学学術研究院   特任教授・特命教授

    2021

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  • Okayama University   Professor Emeritus

    2021

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  • 岡山大学大学院保健学研究科・医学部 入試委員長、学部長補佐

    2018 - 2021

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  • 岡山大学耐災安全安心センター(全学)   部門長、副センター長併任

    2014 - 2018

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  • 金沢大学大学院 招聘講師

    2010

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  • 東京工業大学大学院 非常勤講師

    2010

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  • 岡山大学大学院保健学研究科・医学部 教授

    2007 - 2021

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  • 岡山大学医学部 教授

    2003 - 2007

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  • 岡山大学大学院自然科学研究科博士後期課程(薬学系) 教授兼担

    2003 - 2007

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  • 岡山大学医学部 助教授

    1999 - 2003

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  • 岡山大学大学院自然科学研究科博士後期課程(薬学系) 助教授兼担

    1999 - 2003

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  • 東京大学 客員研究員

    1996 - 1999

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  • 理化学研究所 研究嘱託(非常勤)

    1987 - 1989

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  • 電力中央研究所 上席研究員他

    1982 - 1999

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  • Meiji Pharmaceutical University

    1998 - 1999

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  • 静岡県立大学大学院   非常勤講師

    1997 - 1998

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Professional Memberships

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Committee Memberships

  •   国立大学教育研究評価委員会 専門委員  

    2020 - 2021   

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  • 日本原子力学会   評議員、フェロー、理事  

    2018   

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  • 日本原子力学会   中国・四国支部副支部長、支部長、大会現地委員会委員長  

    2016 - 2020   

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    Committee type:Academic society

    日本原子力学会

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  • 日本ラドン研究推進協会   副理事長  

    2009 - 2021   

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    Committee type:Academic society

    日本ラドン研究推進協会

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  • 原子力分野における大学連携ネットワーク連携協力推進協議会   委員  

    2008   

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  • ラドン温泉医療による健康日本推進三朝会議   理事  

    2008 - 2021   

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    Committee type:Academic society

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  • Society for Free Radical Research International   正会員  

    2007   

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    Committee type:Academic society

    国際フリーラジカル学会(Society for Free Radical Research)

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  • 日本酸化ストレス学会   評議員・代議員、理事  

    2001   

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    Committee type:Academic society

    日本酸化ストレス学会

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  • 中国電力   代表アドバイザー  

    2001   

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Papers

  • Immunomodulatory effects of radon inhalation on lipopolysaccharide-induced inflammation in mice Reviewed

    Takahiro Kataoka, Shota Naoe, Kaito Murakami, Yuki Fujimoto, Ryohei Yukimine, Ayumi Tanaka, Kiyonori Yamaoka

    2022.8

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    DOI: 10.3390/ijerph191710632

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  • Potential inhibitory effects of low-dose thoron inhalation and ascorbic acid administration on alcohol-induced hepatopathy in mice Reviewed

    Takahiro Kataoka, Tsuyoshi Ishida, Shota Naoe, Norie Kanzaki, Akihiro Sakoda, Hiroshi Tanaka, Fumihiro Mitsunobu, Kiyonori Yamaoka

    Journal of Radiation Research   63 ( 5 )   719 - 729   2022.7

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    Authorship:Last author, Corresponding author   Publishing type:Research paper (scientific journal)   Publisher:Oxford University Press (OUP)  

    Abstract

    Although thoron inhalation exerts antioxidative effects in several organs, there are no reports on whether it inhibits oxidative stress-induced damage. In this study, we examined the combined effects of thoron inhalation and ascorbic acid (AA) administration on alcohol-induced liver damage. Mice were subjected to thoron inhalation at 500 or 2000 Bq/m3 and were administered 50% ethanol (alcohol) and 300 mg/kg AA. Results showed that although alcohol administration increased the levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) in the serum, the combination of thoron inhalation (500 Bq/m3) and AA administration 24 h after alcohol administration effectively inhibited alcohol-induced liver damage. The combination of thoron inhalation (500 Bq/m3) and AA administration 24 h after alcohol administration increased catalase (CAT) activity. Alcohol administration significantly decreased glutathione (GSH) levels in the liver. The GSH content in the liver after 2000 Bq/m3 thoron inhalation was lower than that after 500 Bq/m3 thoron inhalation. These findings suggest that the combination of thoron inhalation at 500 Bq/m3 and AA administration has positive effects on the recovery from alcohol-induced liver damage. The results also suggested that thoron inhalation at 500 Bq/m3 was more effective than that at 2000 Bq/m3, possibly because of the decrease in GSH content in the liver. In conclusion, the combination of thoron inhalation at 500 Bq/m3 and AA administration promoted an early recovery from alcohol-induced liver damage.

    DOI: 10.1093/jrr/rrac046

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  • Mechanisms of action of radon therapy on cytokine levels in normal mice and rheumatoid arthritis mouse model Reviewed

    Takahiro Kataoka, Shota Naoe, Kaito Murakami, Ryohei Yukimine, Yuki Fujimoto, Norie Kanzaki, Akihiro Sakoda, Fumihiro Mitsunobu, Kiyonori Yamaoka

    Journal of Clinical Biochemistry and Nutrition   70 ( 2 )   154 - 159   2022.3

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  • Confirmation of efficacy, elucidation of mechanism and new search for indications of radon therapy Reviewed

    Kiyonori Yamaoka, Takahiro Kataoka

    Journal of Clinical Biochemistry and Nutrition   70 ( 2 )   87 - 92   2022.3

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  • Radon inhalation decreases DNA damage induced by oxidative stress in mouse organs via the activation of antioxidative functions Reviewed International journal

    Takahiro Kataoka, Hina Shuto, Shota Naoe, Junki Yano, Norie Kanzaki, Akihiro Sakoda, Hiroshi Tanaka, Katsumi Hanamoto, Fumihiro Mitsunobu, Hiroaki Terato, Kiyonori Yamaoka

    Journal of Radiation Research   62 ( 5 )   861 - 867   2021.9

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    <title>Abstract</title>
    Radon inhalation decreases the level of lipid peroxide (LPO); this is attributed to the activation of antioxidative functions. This activation contributes to the beneficial effects of radon therapy, but there are no studies on the risks of radon therapy, such as DNA damage. We evaluated the effect of radon inhalation on DNA damage caused by oxidative stress and explored the underlying mechanisms. Mice were exposed to radon inhalation at concentrations of 2 or 20 kBq/m3 (for one, three, or 10 days). The 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels decreased in the brains of mice that inhaled 20 kBq/m3 radon for three days and in the kidneys of mice that inhaled 2 or 20 kBq/m3 radon for one, three or 10 days. The 8-OHdG levels in the small intestine decreased by approximately 20–40% (2 kBq/m3 for three days or 20 kBq/m3 for one, three or 10 days), but there were no significant differences in the 8-OHdG levels between mice that inhaled a sham treatment and those that inhaled radon. There was no significant change in the levels of 8-oxoguanine DNA glycosylase, which plays an important role in DNA repair. However, the level of Mn-superoxide dismutase (SOD) increased by 15–60% and 15–45% in the small intestine and kidney, respectively, following radon inhalation. These results suggest that Mn-SOD probably plays an important role in the inhibition of oxidative DNA damage.

    DOI: 10.1093/jrr/rrab069

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  • Evaluation of the redox state in mouse organs following radon inhalation Reviewed International journal

    Takahiro Kataoka, Norie Kanzaki, Akihiro Sakoda, Hina Shuto, Junki Yano, Shota Naoe, Hiroshi Tanaka, Katsumi Hanamoto, Hiroaki Terato, Fumihiro Mitsunobu, Kiyonori Yamaoka

    Journal of Radiation Research   62 ( 2 )   206 - 216   2021.3

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    <title>Abstract</title>
    Radon inhalation activates antioxidative functions in mouse organs, thereby contributing to inhibition of oxidative stress-induced damage. However, the specific redox state of each organ after radon inhalation has not been reported. Therefore, in this study, we evaluated the redox state of various organs in mice following radon inhalation at concentrations of 2 or 20 kBq/m3 for 1, 3 or 10 days. Scatter plots were used to evaluate the relationship between antioxidative function and oxidative stress by principal component analysis (PCA) of data from control mice subjected to sham inhalation. The results of principal component (PC) 1 showed that the liver and kidney had high antioxidant capacity; the results of PC2 showed that the brain, pancreas and stomach had low antioxidant capacities and low lipid peroxide (LPO) content, whereas the lungs, heart, small intestine and large intestine had high LPO content but low antioxidant capacities. Furthermore, using the PCA of each obtained cluster, we observed altered correlation coefficients related to glutathione, hydrogen peroxide and LPO for all groups following radon inhalation. Correlation coefficients related to superoxide dismutase in organs with a low antioxidant capacity were also changed. These findings suggested that radon inhalation could alter the redox state in organs; however, its characteristics were dependent on the total antioxidant capacity of the organs as well as the radon concentration and inhalation time. The insights obtained from this study could be useful for developing therapeutic strategies targeting individual organs.

    DOI: 10.1093/jrr/rraa129

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  • Comparison of antioxidative effects between radon and thoron inhalation in mouse organs. Reviewed International journal

    Yusuke Kobashi, Takahiro Kataoka, Norie Kanzaki, Tsuyoshi Ishida, Akihiro Sakoda, Hiroshi Tanaka, Yuu Ishimori, Fumihiro Mitsunobu, Kiyonori Yamaoka

    Radiation and environmental biophysics   59 ( 3 )   473 - 482   2020.8

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:SPRINGER  

    Radon therapy has been traditionally performed globally for oxidative stress-related diseases. Many researchers have studied the beneficial effects of radon exposure in living organisms. However, the effects of thoron, a radioisotope of radon, have not been fully examined. In this study, we aimed to compare the biological effects of radon and thoron inhalation on mouse organs with a focus on oxidative stress. Male BALB/c mice were randomly divided into 15 groups: sham inhalation, radon inhalation at a dose of 500 Bq/m3 or 2000 Bq/m3, and thoron inhalation at a dose of 500 Bq/m3 or 2000 Bq/m3 were carried out. Immediately after inhalation, mouse tissues were excised for biochemical assays. The results showed a significant increase in superoxide dismutase and total glutathione, and a significant decrease in lipid peroxide following thoron inhalation under several conditions. Additionally, similar effects were observed for different doses and inhalation times between radon and thoron. Our results suggest that thoron inhalation also exerts antioxidative effects against oxidative stress in organs. However, the inhalation conditions should be carefully analyzed because of the differences in physical characteristics between radon and thoron.

    DOI: 10.1007/s00411-020-00843-0

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  • X-Irradiation at 0.5 Gy after the forced swim test reduces forced swimming-induced immobility in mice Reviewed International journal

    Takahiro Kataoka, Hina Shuto, Junki Yano, Shota Naoe, Tsuyoshi Ishida, Tetsuya Nakada, Keiko Yamato, Katsumi Hanamoto, Takaharu Nomura, Kiyonori Yamaoka

    Journal of Radiation Research   61 ( 4 )   517 - 523   2020.7

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    <title>Abstract</title>
    The forced swim test (FST) is a screening model for antidepressant activity; it causes immobility and induces oxidative stress. We previously reported that radon inhalation has antidepressant-like effects in mice potentially through the activation of antioxidative functions upon radon inhalation. This study aimed to investigate the effect of prior and post low-dose X-irradiation (0.1, 0.5, 1.0 and 2.0 Gy) on FST-induced immobility and oxidative stress in the mouse brain, and the differences, if any, between the two. Mice received X-irradiation before or after the FST repeatedly for 5 days. In the post-FST-irradiated group, an additional FST was conducted 4 h after the last irradiation. Consequently, animals receiving prior X-irradiation (0.1 Gy) had better mobility outcomes than sham-irradiated mice; however, their levels of lipid peroxide (LPO), an oxidative stress marker, remained unchanged. However, animals that received post-FST X-irradiation (0.5 Gy) had better mobility outcomes and their LPO levels were significantly lower than those of the sham-irradiated mice. The present results indicate that 0.5 Gy X-irradiation after FST inhibits FST-induced immobility and oxidative stress in mice.

    DOI: 10.1093/jrr/rraa022

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  • Comparative Effects of Radon Inhalation According to Mouse Strain and Cisplatin Dose in a Cisplatin-induced Renal Damage Model Reviewed

    Sasaoka Kaori, Kataoka Takahiro, Kanzaki Norie, Kobashi Yusuke, Sakoda Akihiro, Ishimori Yuu, Yamaoka Kiyonori

    Pakistan Journal of Zoology   50 ( 3 )   1157 - 1170   2018.6

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    Cisplatin (CDDP) is widely used for treating solid cancers; however, it induces nephrotoxicity caused by oxidative stress. Here, we investigated whether radon inhalation has different effects against CDDP-induced renal injury in two mouse strains differing in radiosensitivity, and determined the appropriate dose of CDDP combined with radon inhalation for highly radiosensitive mice. CDDP was administered at 20 mg/kg weight to C57BL/6J and BALB/c mice after radon inhalation at 1000 Bq/m(3) and 2000 Bq/m(3) for 24 h. Radon inhalation had a slight positive effect against CDDP toxicity in C57BL/6J mice with respect to improved hair condition, whereas radon inhalation exacerbated CDDP-induced toxicity in BALB/c mice, such as a decrease in hair condition, higher creatinine levels, and decreased antioxidant contents (catalase and glutathione). When BALB/c mice were treated with a lower dose of CDDP (15 mg/kg) after 1000 Bq/m(3) radon inhalation, the creatinine level was reduced and the superoxide dismutase content was increased, suggesting that this combination might have a protective effect against the CDDP-induced renal damage. The supportive effect of radon inhalation shows its good potential as a candidate treatment to alleviate CDDP-induced renal damage in veterinary medicine.

    DOI: 10.17582/journal.pjz/2018.50.3.1157.1170

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  • Radon inhalation induces manganese-superoxide dismutase in mouse brain via nuclear factor-κB activation Reviewed International journal

    Takahiro Kataoka, Reo Etani, Norie Kanzaki, Yusuke Kobashi, Yuto Yunoki, Tsuyoshi Ishida, Akihiro Sakoda, Yuu Ishimori, Kiyonori Yamaoka

    Journal of Radiation Research   58 ( 6 )   887 - 893   2017.11

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    <title>Abstract</title>
    Although radon inhalation increases superoxide dismutase (SOD) activities in mouse organs, the mechanisms and pathways have not yet been fully clarified. The aim of this study was to determine the details of SOD activation in mouse brain tissue following the inhalation of radon at concentrations of 500 or 2000 Bq/m3 for 24 h. After inhalation, brains were removed quickly for analysis. Radon inhalation increased the manganese (Mn)-SOD level and mitochondrial SOD activity. However, the differences were not significant. There were no changes in the Cu/Zn-SOD level or cytosolic SOD activity. Radon inhalation increased the brain nuclear factor (NF)-κB content, which regulates the induction of Mn-SOD, in the nuclear and cytosolic compartments. The level of inhibitor of nuclear factor κB kinase subunit β (IKK-β), which activates NF-κB, was slightly increased by radon inhalation. The expression of cytoplasmic ataxia-telangiectasia mutated kinase in mice inhaling radon at 500 Bq/m3 was 50% higher than in control mice. In addition, NF-κB–inducing kinase was slightly increased after inhaling radon at 2000 Bq/m3. These findings suggest that radon inhalation might induce Mn-SOD protein via NF-κB activation that occurs in response to DNA damage and oxidative stress.

    DOI: 10.1093/jrr/rrx048

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  • Protective effects of hot spring water drinking and radon inhalation on ethanol-induced gastric mucosal injury in mice Reviewed International journal

    Reo Etani, Takahiro Kataoka, Norie Kanzaki, Akihiro Sakoda, Hiroshi Tanaka, Yuu Ishimori, Fumihiro Mitsunobu, Takehito Taguchi, Kiyonori Yamaoka

    Journal of Radiation Research   58 ( 5 )   614 - 625   2017.5

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    Radon therapy using radon (Rn-222) gas is classified into two types of treatment: inhalation of radon gas and drinking water containing radon. Although short- or long-term intake of spa water is effective in increasing gastric mucosal blood flow, and spa water therapy is useful for treating chronic gastritis and gastric ulcer, the underlying mechanisms for and precise effects of radon protection against mucosal injury are unclear. In the present study, we examined the protective effects of hot spring water drinking and radon inhalation on ethanol-induced gastric mucosal injury in mice. Mice inhaled radon at a concentration of 2000 Bq/m(3) for 24 h or were provided with hot spring water for 2 weeks. The activity density of Rn-222 ranged from 663 Bq/l (start point of supplying) to 100 Bq/l (end point of supplying). Mice were then orally administered ethanol at three concentrations. The ulcer index (UI), an indicator of mucosal injury, increased in response to the administration of ethanol; however, treatment with either radon inhalation or hot spring water inhibited the elevation in the UI due to ethanol. Although no significant differences in antioxidative enzymes were observed between the radon-treated groups and the non-treated control groups, lipid peroxide levels were significantly lower in the stomachs of mice pre-treated with radon or hot spring water. These results suggest that hot spring water drinking and radon inhalation inhibit ethanol-induced gastric mucosal injury.

    DOI: 10.1093/jrr/rrx021

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  • Analysis of liver damage from radon, X-ray, or alcohol treatments in mice using a self-organizing map Reviewed International journal

    Norie Kanzaki, Takahiro Kataoka, Reo Etani, Kaori Sasaoka, Akihiro Kanagawa, Kiyonori Yamaoka

    Journal of Radiation Research   58 ( 1 )   33 - 40   2017.1

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    <title>Abstract</title>
    In our previous studies, we found that low-dose radiation inhibits oxidative stress–induced diseases due to increased antioxidants. Although these effects of low-dose radiation were demonstrated, further research was needed to clarify the effects. However, the analysis of oxidative stress is challenging, especially that of low levels of oxidative stress, because antioxidative substances are intricately involved. Thus, we proposed an approach for analysing oxidative liver damage via use of a self-organizing map (SOM)—a novel and comprehensive technique for evaluating hepatic and antioxidative function. Mice were treated with radon inhalation, irradiated with X-rays, or subjected to intraperitoneal injection of alcohol. We evaluated the oxidative damage levels in the liver from the SOM results for hepatic function and antioxidative substances. The results showed that the effects of low-dose irradiation (radon inhalation at a concentration of up to 2000 Bq/m3, or X-irradiation at a dose of up to 2.0 Gy) were comparable with the effect of alcohol administration at 0.5 g/kg bodyweight. Analysis using the SOM to discriminate small changes was made possible by its ability to ‘learn’ to adapt to unexpected changes. Moreover, when using a spherical SOM, the method comprehensively examined liver damage by radon, X-ray, and alcohol. We found that the types of liver damage caused by radon, X-rays, and alcohol have different characteristics. Therefore, our approaches would be useful as a method for evaluating oxidative liver damage caused by radon, X-rays and alcohol.

    DOI: 10.1093/jrr/rrw083

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  • Difference in the action mechanism of radon inhalation and radon hot spring water drinking in suppression of hyperuricemia in mice Reviewed International journal

    Reo Etani, Takahiro Kataoka, Norie Kanzaki, Akihiro Sakoda, Hiroshi Tanaka, Yuu Ishimori, Fumihiro Mitsunobu, Kiyonori Yamaoka

    Journal of Radiation Research   57 ( 3 )   250 - 257   2016.6

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    Although radon therapy is indicated for hyperuricemia, the underlying mechanisms of action have not yet been elucidated in detail. Therefore, we herein examined the inhibitory effects of radon inhalation and hot spring water drinking on potassium oxonate (PO)-induced hyperuricemia in mice. Mice inhaled radon at a concentration of 2000 Bq/m(3) for 24 h or were given hot spring water for 2 weeks. Mice were then administrated PO at a dose of 500 mg/kg. The results obtained showed that serum uric acid levels were significantly increased by the administration of PO. Radon inhalation or hot spring water drinking significantly inhibited elevations in serum uric acid levels through the suppression of xanthine oxidase activity in the liver. Radon inhalation activated anti-oxidative functions in the liver and kidney. These results suggest that radon inhalation inhibits PO-induced hyperuricemia by activating anti-oxidative functions, while hot spring water drinking may suppress PO-induced elevations in serum uric acid levels through the pharmacological effects of the chemical compositions dissolved in it.

    DOI: 10.1093/jrr/rrw014

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  • Evaluating the protective effects of radon inhalation or ascorbic acid treatment after transient global cerebral ischemic injury in gerbils Reviewed

    Takahiro Kataoka, Reo Etani, Norie Kanzaki, Kaori Sasaoka, Yusuke Kobashi, Katsumi Hanamoto, Takehito Taguchi, Kiyonori Yamaoka

    Journal of Nuclear Science and Technology   53 ( 11 )   1681 - 1685   2016

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    In this study, we compared the protective effects of radon inhalation and ascorbic acid administration on transient global cerebral ischemic injury in gerbils. Gerbils were treated with radon inhalation (2000 Bq/m(3), 24 hours) or ascorbic acid (100, 300, or 500mg/kg body weight). Then, transient global cerebral ischemia was induced by bilateral occlusion of the common carotid artery. Results showed that the number of damaged neurons was significantly increased in gerbils that underwent ischemia compared with that in control gerbils. However, the number of damaged neurons in gerbils treated with radon or 500mg/kg of ascorbic acid before ischemia was significantly lower than gerbils who were subjected to ischemia without any pretreatment, and the protective effects of radon inhalation were similar to the effects of administering 500mg/kg ascorbic acid. The levels of superoxide dismutase (SOD) and total glutathione (t-GSH) in brain tissue were increased to a similar extent by pretreatment with radon inhalation or 500mg/kg of ascorbic acid. These findings suggested that radon inhalation has a protective antioxidative effect against transient global cerebral ischemic injury similar to 500mg/kg ascorbic acid treatment.

    DOI: 10.1080/00223131.2016.1198731

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  • Radon inhalation suppresses nephropathy in streptozotocin-induced type-1 diabetic mice Reviewed

    Yuichi Nishiyama, Takahiro Kataoka, Keiko Yamato, Reo Etani, Takehito Taguchi, Kiyonori Yamaoka

    Journal of Nuclear Science and Technology   53 ( 6 )   909 - 915   2016

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    In this study, we investigated the suppressive effects of radon inhalation against nephropathy in C57BL/6J mice with type-1 diabetes induced by intraperitoneal injection of streptozotocin (50 mg/kg weight, given five times). Four weeks after diabetes induction, the diabetic mice were continuously treated with inhaled radon-222 of 2000 Bq/m(3) or air only (sham) for four weeks. The results showed that radon inhalation did not affect type-1 diabetic symptoms such as body weight loss, hyperglycemia, and hypoinsulinemia. However, diabetic mice treated with radon showed lower urinary albumin excretion and fibrotic change in renal glomeruli compared with diabetic mice not treated with radon. Furthermore, renal superoxide dismutase activity and glutathione content were significantly higher in diabetic mice treated with radon than in diabetic mice not treated with radon. These findings suggested that radon inhalation enhanced renal antioxidants activities, resulting in the suppression of diabetic nephropathy. This study may contribute to the development of a novel approach in the treatment of nephropathy for diabetic patients.

    DOI: 10.1080/00223131.2015.1078751

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  • Activation of Antioxidative Functions by Radon Inhalation Enhances the Mitigation Effects of Pregabalin on Chronic Constriction Injury-Induced Neuropathic Pain in Mice Reviewed International journal

    Takahiro Kataoka, Shunsuke Horie, Reo Etani, Norie Kanzaki, Kaori Sasaoka, Yusuke Kobashi, Katsumi Hanamoto, Kiyonori Yamaoka

    Oxidative Medicine and Cellular Longevity   Article ID 9853692   1 - 8   2016

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:HINDAWI LTD  

    Radon inhalation brings pain relief for chronic constriction injury- (CCI-) induced neuropathic pain in mice due to the activation of antioxidative functions, which is different from the mechanism of the pregabalin effect. In this study, we assessed whether a combination of radon inhalation and pregabalin administration is more effective against neuropathic pain than radon or pregabalin only. Mice were treated with inhaled radon at a concentration of 1,000 Bq/m(3) for 24 hours and pregabalin administration after CCI surgery. In mice treated with pregabalin at a dose of 3 mg/kg weight, the 50% paw withdrawal threshold of mice treated with pregabalin or radon and pregabalin was significantly increased, suggesting pain relief. The therapeutic effects of radon inhalation or the combined effects of radon and pregabalin (3 mg/kg weight) were almost equivalent to treatment with pregabalin at a dose of 1.4 mg/kg weight or 4.1 mg/kg weight, respectively. Radon inhalation and the combination of radon and pregabalin increased antioxidant associated substances in the paw. The antioxidant substances increased much more in radon inhalation than in pregabalin administration. These findings suggested that the activation of antioxidative functions by radon inhalation enhances the pain relief of pregabalin and that this combined effect is probably an additive effect.

    DOI: 10.1155/2016/9853692

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  • Combined effects of radon inhalation and antioxidant vitamin administration on acute alcohol-induced hepatopathy in mice Reviewed

    Reo Etani, Takahiro Kataoka, Yuichi Nishiyama, Yuji Takata, Kiyonori Yamaoka

    Journal of Nuclear Science and Technology   52 ( 12 )   1512 - 1518   2015.12

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    It has been reported that radon inhalation activates antioxidative functions in liver and has an antioxidative effect against hepatopathy similar to that of the antioxidative effects of ascorbic acid (VC) or -tocopherol (VE). In this study, we examined the combined effects of radon inhalation and antioxidant vitamin administration on acute alcohol-induced hepatopathy in mice. ICR mice were subjected to intraperitoneal (i.p.) administration of alcohol after pretreating with air only (sham) or radon at a concentration of approximately 2000 Bq/m(3) for 24 hours and i.p. administration of VC (300 mg/kg body weight) or VE (300 mg/kg body weight). In mice injected with alcohol, the combined radon and antioxidant vitamins treatment significantly decreased the activities of glutamic oxaloacetic transaminase in serum compared to not only the alcohol-administered group (sham group), but also the radon inhalation with alcohol administration group or the vitamin and alcohol administration group. In addition, radon inhalation significantly increased the antioxidant level, in such as the catalase activity and the total glutathione content in liver compared to the sham group. These results suggested that the combined radon and antioxidant vitamin treatment could effectively inhibit alcohol-induced hepatopathy in mice without any antagonizing action.

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  • Recent studies on anti-inflammatory effects of radon inhalation in mice Reviewed

    Norie Kanzaki, Takahiro Kataoka, Reo Etani, Kiyonori Yamaoka

    Inflammation & Cell Signaling   1 ( 2 )   1 - 5   2015

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  • Radon Inhalation Protects Against Transient Global Cerebral Ischemic Injury in Gerbils Reviewed International journal

    Takahiro Kataoka, Reo Etani, Yuji Takata, Yuichi Nishiyama, Atsushi Kawabe, Masayuki Kumashiro, Takehito Taguchi, Kiyonori Yamaoka

    Inflammation   37 ( 5 )   1675 - 1682   2014.10

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    Although brain disorders are not the main indication for radon therapy, our previous study suggested that radon inhalation therapy might mitigate brain disorders. In this study, we assessed whether radon inhalation protects against transient global cerebral ischemic injury in gerbils. Gerbils were treated with inhaled radon at a concentration of 2,000 Bq/m(3) for 24 h. After radon inhalation, transient global cerebral ischemia was induced by bilateral occlusion of the common carotid artery. Results showed that transient global cerebral ischemia induced neuronal damage in hippocampal CA1, and the number of damaged neurons was significantly increased compared with control. However, radon treatment inhibited ischemic damage. Superoxide dismutase (SOD) activity in the radon-treated gerbil brain was significantly higher than that in sham-operated gerbils. These findings suggested that radon inhalation activates antioxidative function, especially SOD, thereby inhibiting transient global cerebral ischemic injury in gerbils.

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  • Effects of cream containing ultralow volume radionuclides on carrageenan-induced inflammatory paw edema in mice Reviewed

    Takahiro Kataoka, Yuji Takata, Reo Etani, Yuichi Nishiyama, Atsushi Kawabe, Katsumi Hanamoto, Takehito Taguchi, Kiyonori Yamaoka

    Biochemistry & Physiology   3 ( 2 )   133 - 137   2014

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    DOI: 10.4172/2168-9652.1000133

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  • Preventive and curative effects of radon inhalation on chronic constriction injury-induced neuropathic pain in mice Reviewed

    K. Yamato, T. Kataoka, Y. Nishiyama, T. Taguchi, K. Yamaoka

    European Journal of Pain   17 ( 4 )   480 - 492   2013.4

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    Background Radon therapy is clinically useful for the treatment of pain-related diseases. However, there have been no studies regarding the effects of radon inhalation on neuropathic pain. In this study, we aimed to determine whether radon inhalation actually induced a remission of neuropathic pain and improved the quality of life. Methods First, we investigated the antinociceptive effects of radon inhalation in the chronic constriction injury (CCI) model of neuropathic pain. We evaluated pain behaviour in mice before and after CCI surgery, using von Frey test. Pretreated mice received CCI surgery immediately after 24-h inhalation of radon at background (BG) concentration (c. 19Bq/m3), or at a concentration of 1000 or 2000Bq/m3, and post-treated mice inhaled similar levels of radon 2 days after CCI surgery. Results CCI surgery induced mechanical allodynia and hyperalgesia on a plantar surface of mice, as assessed using von Frey test, and 2000Bq/m3 radon inhalation alleviated hyperalgesic conditions 2237% compared to BG level concentration. Concurrently, CCI surgery increased norepinephrine (NE), tumour necrosis factor-alpha (TNF-) and nitric oxide (NO) concentrations in plasma, and leukocyte migration in paws. Furthermore, CCI-induced neuropathy reduced superoxide dismutase (SOD) activity. Treatment with radon inhalation, specifically at a concentration of 2000Bq/m3, produced antinociceptive effects, i.e., lowered plasma TNF-, NE and NO levels and restored SOD activity, as well as pain-related behaviour. Conclusions This study showed that inhalation of 2000Bq/m3 radon prevented and alleviated CCI-induced neuropathic pain in mice.

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  • Antinociceptive Effects of Radon Inhalation on Formalin-Induced Inflammatory Pain in Mice Reviewed International journal

    Keiko Yamato, Takahiro Kataoka, Yuichi Nishiyama, Takehito Taguchi, Kiyonori Yamaoka

    Inflammation   36 ( 2 )   355 - 363   2013.4

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    Radon therapy is clinically useful for the treatment of inflammatory diseases. The mechanisms of pain relief remain to be fully elucidated. In this study, we investigated the antinociceptive effects of radon inhalation in a mouse model of formalin-induced inflammatory pain. Immediately, after radon inhalation at a concentration of background level (ca. 19 Bq/m(3)), 1,000 or 2,000 Bq/m(3) for 24 h, 1.35 % formalin (0.5 % formaldehyde in saline, 20 mu l) was subcutaneously injected into the hind paw of mice, and we measured licking response time. Radon inhalation inhibited the second phase of response in formalin test. Formalin administration induced nociception and increased tumor necrosis factor alpha (TNF-alpha) and nitric oxide (NO) levels in serum and leukocyte migration in paws. Concurrently, formalin injection decreased antioxidative functions. Radon inhalation produced antinociceptive effects, i.e., lowered serum TNF-alpha and NO levels, and restored antioxidative functions. The results showed that radon inhalation inhibited formalin-induced inflammatory pain.

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  • Suppression of streptozotocin-induced type-1 diabetes in mice by radon inhalation Reviewed

    Y. Nishiyama, T. Kataoka, J. Teraoka, A. Sakoda, H. Tanaka, Y. Ishimori, F. Mitsunobu, T. Taguchi, K. Yamaoka

    Physiological Research   62 ( 1 )   57 - 66   2013

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    We examined the protective effect of radon inhalation on streptozotocin (STZ)-induced type-1 diabetes in mice. Mice inhaled radon at concentrations of 1000, 2500, and 5500 Bq/m3 for 24 hours before STZ administration. STZ administration induced characteristics of type-1 diabetes such as hyperglycemia and hypoinsulinemia
    however, radon inhalation at doses of 1000 and 5500 Bq/m3 significantly suppressed the elevation of blood glucose in diabetic mice. Serum insulin was significantly higher in mice pre-treated with radon at a dose of 1000 Bq/m3 than in mice treated with a sham. In addition, superoxide dismutase activities and total glutathione contents were significantly higher and lipid peroxide was significantly lower in mice pre-treated with radon at doses of 1000 and 5500 Bq/m3 than in mice treated with a sham. These results were consistent with the result that radon inhalation at 1000 and 5500 Bq/m3 suppressed hyperglycemia. These findings suggested that radon inhalation suppressed STZ-induced type-1 diabetes through the enhancement of antioxidative functions in the pancreas. © 2013 Institute of Physiology v.v.i., Academy of Sciences of the Czech Republic, Prague, Czech Republic.

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  • Comparative study on the inhibitory effects of antioxidant vitamins and radon on carbon tetrachloride-induced Hepatopathy Reviewed International journal

    Takahiro Kataoka, Yuichi Nishiyama, Keiko Yamato, Junichi Teraoka, Yuji Morii, Akihiro Sakoda, Yuu Ishimori, Takehito Taguchi, Kiyonori Yamaoka

    Journal of Radiation Research   53 ( 6 )   830 - 839   2012.11

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    We have previously reported that radon inhalation activates anti-oxidative functions and inhibits carbon tetrachloride (CCl4)-induced hepatopathy. It has also been reported that antioxidant vitamins can inhibit CCl4-induced hepatopathy. In the current study, we examined the comparative efficacy of treatment with radon, ascorbic acid and alpha-tocopherol on CCl4-induced hepatopathy. Mice were subjected to intraperitoneal injection of CCl4 after inhaling approximately 1000 or 2000 Bq/m(3) radon for 24 h, or immediately after intraperitoneal injection of ascorbic acid (100, 300, or 500 mg/kg bodyweight) or alpha-tocopherol (100, 300, or 500 mg/kg bodyweight). We estimated the inhibitory effects on CCl4-induced hepatopathy based on hepatic function-associated parameters, oxidative damage-associated parameters and histological changes. The results revealed that the therapeutic effects of radon inhalation were almost equivalent to treatment with ascorbic acid at a dose of 500 mg/kg or alpha-tocopherol at a dose of 300 mg/kg. The activities of superoxide dismutase, catalase, and glutathione peroxidase in the liver were significantly higher in mice exposed to radon than in mice treated with CCl4 alone. These findings suggest that radon inhalation has an anti-oxidative effect against CCl4-induced hepatopathy similar to the anti-oxidative effects of ascorbic acid or alpha-tocopherol due to the induction of anti-oxidative functions.

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  • Radioactivity of Pb-210 in Japanese cigarettes and radiation dose from smoking inhalation Reviewed

    A. Sakoda, K. Fukao, A. Kawabe, T. Kataoka, K. Hanamoto, K. Yamaoka

    Radiation Protection Dosimetry   150 ( 1 )   109 - 113   2012.6

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    It is well known that cigarette tobaccos contain naturally occurring radioactive nuclides such as Pb-210 and Po-210. In many countries, the radioactivity of tobaccos has been measured to estimate the effective dose from smoking inhalation. The present study covered 24 cigarette brands including the top 20 of sales in Japan between April 2008 and March 2009. The activity concentrations of Pb-210 were measured by gamma-ray spectrometry, and then those of its progeny (Po-210) were evaluated assuming the radioactive equilibrium between the two nuclides. Their concentrations were in the range of 214 mBq cigarette(1) with an arithmetic mean of 83 mBq cigarette(1). The annual committed effective doses were also calculated, based on the scenario that a smoker consumes 20 cigarettes a day. The average doses from Pb-210 and Po-210 inhalations were 229 and 6827 Sv y(1), respectively.

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  • Protective Effects of Radon Inhalation on Carrageenan-Induced Inflammatory Paw Edema in Mice Reviewed

    Takahiro Kataoka, Junichi Teraoka, Akihiro Sakoda, Yuichi Nishiyama, Keiko Yamato, Mayuko Monden, Yuu Ishimori, Takaharu Nomura, Takehito Taguchi, Kiyonori Yamaoka

    Inflammation   35 ( 2 )   713 - 722   2012.6

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  • Study on effects of thoron and thermal treatment for aging-related diseases in humans Reviewed

    Y. Aoyama, T. Kataoka, S. Nakagawa, A. Sakoda, Y. Ishimori, F. Mitsunobu, K. Yamaoka

    Iranian Journal of Radiation Research   9 ( 4 )   221 - 229   2012.3

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    Background: The aim of this study was to analyze the effects of thoron and thermal treatment for aging-related diseases in humans. Materials and Methods: All subjects inhaled thoron with a high concentration (about 4900 Bq/m(3)) for 2 weeks. Blood pressures were measured and blood samples were collected after each treatment 1, 2 and 3 weeks after the first treatment. Results: The alpha-atrial natriuretic peptide level of the rheumatoid arthritis group was increased and the blood pressure was significantly decreased. Superoxide dismutase activity of rheumatoid arthritis group was significantly increased by treatment. In addition, thoron and thermal treatment significantly enhanced the concanavalin A-induced mitogen response and increased the level of CD4-positive cells; it decreased the level of CD8-positive cells. The results suggest that thoron and thermal treatment activates antioxidative function. Furthermore, these findings suggest that thoron and thermal treatment prevents diabetic ketoacidosis and contributes to the prevention of aging-related diseases. Conclusion: Thoron and thermal therapy may be part of the mechanism for the alleviation of diabetes mellitus and rheumatoid arthritis. Iran. J. Radiat. Res., 2012; 9(4): 221-229

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  • Inhibitory Effects of Prior Low-dose X-irradiation on Cold-induced Brain Injury in Mouse Reviewed International journal

    Masaaki Yoshimoto, Takahiro Kataoka, Teruaki Toyota, Takehito Taguchi, Kiyonori Yamaoka

    Inflammation   35 ( 1 )   89 - 97   2012.2

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    We examined the inhibitory effects of low-dose X-irradiation on mouse brain tissue with cold-induced injury by comparing tissue samples from three groups of mice: control, sham-irradiated cold-exposed, and X-ray-irradiated (0.5 Gy) cold-exposed mice. The water content in brain increased significantly in the sham-irradiated group following the cold-induced injury relative to the control group. However, water content in brain tissue from the X-ray-irradiated group was significantly lower than that from the sham-irradiated group. Levels of antioxidants, such as superoxide dismutase and glutathione, in brain tissue from the X-ray-irradiated group were higher than those from the sham-irradiated group. Moreover, the cold injury-induced cell death, particularly apoptosis, while low-dose irradiation inhibited cell death, especially among glial cells, but not numeral cells. These findings suggest that prior low-dose X-irradiation activated antioxidant function and inhibited cold-induced brain injury.

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  • Comparative Study on the Inhibitory Effects of alpha-Tocopherol and Radon on Carbon Tetrachloride-Induced Renal Damage Reviewed International journal

    Takahiro Kataoka, Keiko Yamato, Yuichi Nishiyama, Yuji Morii, Reo Etani, Yuji Takata, Katsumi Hanamoto, Atsuishi Kawabe, Akihiro Sakoda, Yuu Ishimori, Takehito Taguchi, Kiyonori Yamaoka

    RENAL FAILURE   34 ( 9 )   1181 - 1187   2012

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    Since the 2011 nuclear accident in Fukushima, the effects of low-dose irradiation, especially internal exposure, are at the forefront of everyone's attention. However, low-dose radiation induced various stimulating effects such as activation of antioxidative and immune functions. In this study, we attempted to evaluate the quantitative effects of the activation of antioxidative activities in kidney induced by radon inhalation on carbon tetrachloride (CCl4)-induced renal damage. Mice were subjected to intraperitoneal (i.p.) injection of CCl4 after inhaling approximately 1000 or 2000 Bq/m(3) radon for 24 h, or immediately after i.p. injection of alpha-tocopherol (100, 300, or 500 mg/kg bodyweight). In case of renal function, radon inhalation at a concentration of 2000 Bq/m(3) has the inhibitory effects similar to alpha-tocopherol treatment at a dose of 300-500 mg/kg bodyweight. The activities of superoxide dismutase and catalase in kidneys were significantly higher in mice exposed to radon as compared to mice treated with CCl4 alone. These findings suggest that radon inhalation has an antioxidative effect against CCl4-induced renal damage similar to the antioxidative effects of alpha-tocopherol due to induction of antioxidative functions.

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  • Suppression of Dextran Sulfate Sodium-Induced Colitis in Mice by Radon Inhalation Reviewed International journal

    Yuichi Nishiyama, Takahiro Kataoka, Keiko Yamato, Takehito Taguchi, Kiyonori Yamaoka

    Mediators of Inflammation   2012 ( 239617 )   1 - 11   2012

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    The enhanced release of reactive oxygen species from activated neutrophils plays important role in the pathogenesis of inflammatory bowel disease. We previously reported that radon inhalation activates antioxidative functions in various organs of mice. In this study, we examined the protective effects of radon inhalation on dextran sulfate sodium- (DSS) induced colitis in mice which were subjected to DSS for 7 days. Mice were continuously treated with air only (sham) or radon at a concentration of 2000 Bq/m(3) from a day before DSS administration to the end of colitis induction. In the results, radon inhalation suppressed the elevation of the disease activity index score and histological damage score induced by DSS. Based on the changes in tumor necrosis factor-alpha in plasma and myeloperoxidase activity in the colon, it was shown that radon inhalation suppressed DSS-induced colonic inflammation. Moreover, radon inhalation suppressed lipid peroxidation of the colon induced by DSS. The antioxidant level (superoxide dismutase and total glutathione) in the colon after DSS administration was significantly higher in mice treated with radon than with the sham. These results suggested that radon inhalation suppressed DSS-induced colitis through the enhancement of antioxidative functions in the colon.

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  • Inhibitory Effects of Pretreatment with Radon on Acute Alcohol-Induced Hepatopathy in Mice Reviewed International journal

    Teruaki Toyota, Takahiro Kataoka, Yuichi Nishiyama, Takehito Taguchi, Kiyonori Yamaoka

    Mediators of Inflammation   2012 ( 382801 )   1 - 10   2012

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    We previously reported that radon inhalation activates antioxidative functions in the liver and inhibits carbon tetrachloride-induced hepatopathy in mice. In addition, it has been reported that reactive oxygen species contribute to alcohol-induced hepatopathy. In this study, we examined the inhibitory effects of radon inhalation on acute alcohol- induced hepatopathy in mice. C57BL/6J mice were subjected to intraperitoneal injection of 50% alcohol (5 g/kg bodyweight) after inhaling approximately 4000 Bq/m(3) radon for 24 h. Alcohol administration significantly increased the activities of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT) in serum, and the levels of triglyceride and lipid peroxide in the liver, suggesting acute alcohol- induced hepatopathy. Radon inhalation activated antioxidative functions in the liver. Furthermore, pretreatment with radon inhibited the depression of hepatic functions and antioxidative functions. These findings suggested that radon inhalation activated antioxidative functions in the liver and inhibited acute alcohol- induced hepatopathy in mice.

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  • Radon Inhalation Protects Mice from Carbon-Tetrachloride-Induced Hepatic and Renal Damage Reviewed International journal

    Takahiro Kataoka, Yuichi Nishiyama, Teruaki Toyota, Masaaki Yoshimoto, Akihiro Sakoda, Yuu Ishimori, Yutaka Aoyama, Takehito Taguchi, Kiyonori Yamaoka

    Inflammation   34 ( 6 )   559 - 567   2011.12

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    We assessed whether radon inhalation provided protection from carbon tetrachloride (CCl4)-induced hepatic and renal damage in mice. Mice were subjected to intraperitoneal injection of CCl4 after inhaling approximately 18 kBq/m(3) radon for 6 h. Radon inhalation significantly increased total glutathione (t-GSH) content and glutathione peroxidase (GPx) activity in the liver and kidney. Injection of CCl4 was associated with significantly higher levels of glutamic oxaloacetic transaminase (GOT) and alkaline phosphatase (ALP) activity and creatinine level in serum, and pretreatment with radon significantly decreased the GOT and ALP activity and creatinine level associated with CCl4 injection, suggesting that radon inhalation alleviates CCl4-induced hepatic and renal damage. The t-GSH contents and GPx activity in the liver and kidney of animals pretreated with radon were significantly higher than those of the CCl4-only group. These findings suggested that radon inhalation activated antioxidative functions and inhibited CCl4-induced hepatic and renal damage in mice.

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  • Study of the Response of Superoxide Dismutase in Mouse Organs to Radon Using a New Large-scale Facility for Exposing Small Animals to Radon Reviewed International journal

    Takahiro Kataoka, Akihiro Sakoda, Yuu Ishimori, Teruaki Toyota, Yuichi Nishiyama, Hiroshi Tanaka, Fumihiro Mitsunobu, Kiyonori Yamaoka

    Journal of Radiation Research   52 ( 6 )   775 - 781   2011.11

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    We examined dose dependent or dose rate dependent changes of superoxide dismutase (SOD) activity using a new large-scale facility for exposing small animals to radon. Mice were exposed to radon at a concentration of 250, 500, 1000, 2000, or 4000 Bq/m(3) for 0.5, 1, 2, 4, or 8 days. When mice were exposed to radon at 2000 day.Bq/m(3), activation of SOD activities in plasma, liver, pancreas, heart, thymus, and kidney showed dose rate effects. Our results also suggested that continuous exposure to radon increased SOD activity, but SOD activity transiently returned to normal levels at around 2 days. Moreover, we classified the organs into four groups (1. plasma, brain, lung; 2. heart, liver, pancreas, small intestine; 3. kidney, thymus; 4. stomach) based on changes in SOD activity. Thymus had the highest responsiveness and stomach had lowest. These data provide useful baseline measurements for future studies on, radon effects.

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  • A comprehensive review of radon emanation measurements for mineral, rock, soil, mill tailing and fly ash Reviewed International journal

    Akihiro Sakoda, Yuu Ishimori, Kiyonori Yamaoka

    Applied Radiation and Isotopes   69 ( 10 )   1422 - 1435   2011.10

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    To our knowledge, this paper is the most comprehensive review to cover most studies, published in the past three decades at least, of radon emanation measurements. The radon emanation fraction, a possibility of radon atoms generated in a material escaping from its grains, has been widely measured for a variety of materials. The aim of this review is to organize a huge number of such data accumulated. The representative values of the emanation fraction for minerals, rocks, soils, mill tailings and fly ashes were derived to be 0.03, 0.13, 0.20, 0.17 and 0.03, respectively. Current knowledge of the emanation processes was also summarized to discuss their affected factors. (C) 2011 Elsevier Ltd. All rights reserved.

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  • Studies on possibility for alleviation of lifestyle diseases by low-dose irradiation or radon inhalation Reviewed International journal

    Takahiro Kataoka, Akihiro Sakoda, Masaaki Yoshimoto, Shinya Nakagawa, Teruaki Toyota, Yuichi Nishiyama, Keiko Yamato, Yuu Ishimori, Atsushi Kawabe, Katsumi Hanamoto, Takehito Taguchi, Kiyonori Yamaoka

    Radiation Protection Dosimetry   146 ( 1-3 )   360 - 363   2011.7

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    Our previous studies showed the possibility that activation of the antioxidative function alleviates various oxidative damages, which are related to lifestyle diseases. Results showed that, low-dose X-ray irradiation activated superoxide dismutase and inhibits oedema following ischaemia-reperfusion. To alleviate ischaemia-reperfusion injury with transplantation, the changes of the antioxidative function in liver graft using low-dose X-ray irradiation immediately after exenteration were examined. Results showed that liver grafts activate the antioxidative function as a result of irradiation. In addition, radon inhalation enhances the antioxidative function in some organs, and alleviates alcohol-induced oxidative damage of mouse liver. Moreover, in order to determine the most effective condition of radon inhalation, mice inhaled radon before or after carbon tetrachloride (CCl(4)) administration. Results showed that radon inhalation alleviates CCl(4)-induced hepatopathy, especially prior inhalation. It is highly possible that adequate activation of antioxidative functions induced by low-dose irradiation can contribute to preventing or reducing oxidative damages, which are related to lifestyle diseases.

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  • A comprehensive review of radon emanation measurements for mineral, rock, soil, mill tailing and fly ash Reviewed

    A.Sakoda, Y.Ishimori, K.Yamaoka

    Applied Radiation and Isotopes   69 ( 10 )   1422 - 1435   2011

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  • Possibilities of Health Beneficial Effects by Low-dose Radiation and its Medical Applications Invited Reviewed

    16 ( 11 )   75 - 79   2011

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  • Differences of natural radioactivity and radon emanation fraction between constituent minerals of rock or soil Reviewed International journal

    Akihiro Sakoda, Yuichi Nishiyama, Katsumi Hanamoto, Yuu Ishimori, Yuki Yamamoto, Takahiro Kataoka, Atsushi Kawabe, Kiyonori Yamaoka

    Applied Radiation and Isotopes   68 ( 6 )   1180 - 1184   2010.12

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    We examined differences in the radioactive characteristics among the main minerals forming granite materials. Using a non-toxic high-density agent, minerals were separated from rock (granite-gneiss) and soil (weathered granite) samples. The natural radioactivity ((238)U and (226)Ra) and radon emanation fraction of the minerals were then studied by gamma-ray spectrometry. The radon emanation fractions (27-43%) of the minerals from the soil were much higher than those (0.6-4.6%) of the rock minerals. Additionally, the emanation fractions differed greatly among the minerals separated from both the bulk rock and soil. These results were discussed in terms of the differences of surface area and radium distribution in the mineral grains. It was noticeable that a higher emanation fraction than expected for quartz was commonly observed in the rock and soil samples. We then estimated the contribution of each constituent mineral to the total radon exhalation from the bulk samples. The result depended not only on the radon emanation fraction, but also on the (226)Ra activity and the mineral content. Furthermore, using the obtained data, we also discussed the effect of grain size on radon emanation and why this has been reported to vary markedly in previous studies.

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  • Applicability and performance of an imaging plate at subzero temperatures Reviewed International journal

    Akihiro Sakoda, Yuu Ishimori, Katsumi Hanamoto, Atsushi Kawabe, Takahiro Kataoka, Tomohiro Nagamatsu, Kiyonori Yamaoka

    Applied Radiation and Isotopes   68 ( 10 )   2013 - 2015   2010.10

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    The performance of imaging plates (IPs) has not been studied at temperatures lower than 0 degrees C. In the present study, an IP was irradiated with gamma rays emitted from the mineral monazite at temperatures between -80 and 30 degrees C to determine its fundamental properties. The IP response as a function of irradiation time was found to be linear, suggesting that the IP works properly at low temperatures. Fading, an effect which should be considered at temperatures of more than 0 degrees C, was not observed at -30 and 80 degrees C. Furthermore, the fading-corrected PSL value of the IP irradiated at 80 degrees C was lower than at other temperatures (30.5 and -30 degrees C). This can be explained by thermostimulated luminescence (TSL). Since the only intensive TSL peak in the temperature range from -80 to 30 degrees C is present at about -43 degrees C, some of the electrons trapped at F centers recombine with holes through the process of TSL before the stored radiation image is read out at room temperature. This finding suggests that the apparent sensitivity of the IP is lower at -80 degrees C although it is similar to sensitivities between -30 and 30 degrees C. This low sensitivity should be corrected to perform quantitative measurements. (C) 2010 Elsevier Ltd. All rights reserved.

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  • Physiologically Based Pharmacokinetic Modeling of Inhaled Radon to Calculate Absorbed Doses in Mice, Rats, and Humans Reviewed

    Akihiro Sakoda, Yuu Ishimori, Atsushi Kawabe, Takahiro Kataoka, Katsumi Hanamoto, Kiyonori Yamaoka

    Journal of Nuclear Science and Technology   47 ( 8 )   731 - 738   2010.8

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    This is the first report to provide radiation doses, arising from inhalation of radon itself, in mice and rats. To quantify absorbed doses to organs and tissues in mice, rats, and humans, we computed the behavior of inhaled radon in their bodies on the basis of a physiologically based pharmacokinetic (PBPK) model. It was assumed that radon dissolved in blood entering the gas exchange compartment is transported to any tissue by the blood circulation to be instantaneously distributed according to a tissue/blood partition coefficient. The calculated concentrations of radon in the adipose tissue and red bone marrow following its inhalation were much higher than those in the others, because of the higher partition coefficients. Compared with a previous experimental data for rats and model calculation for humans, the present calculation was proved to be valid. Absorbed dose rates to organs and tissues were estimated to be within the range of 0.04-1.4 nGy (Bq m(-3))(-1) day(-1) for all the species. Although the dose rates are not so high, it may be better to pay attention to the dose to the red bone marrow from the perspective of radiation protection. For more accurate dose assessment, it is necessary to update tissue/blood partition coefficients of radon that strongly govern the result of the PBPK modeling.

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  • First model of the effect of grain size on radon emanation Reviewed International journal

    Akihiro Sakoda, Katsumi Hanamoto, Yuu Ishimori, Takahiro Kataoka, Atsushi Kawabe, Kiyonori Yamaoka

    Applied Radiation and Isotopes   68 ( 6 )   1169 - 1172   2010.6

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    The present model represents an improvement on previous models of radon emanation from soil by incorporating soil grain size in addition to moisture. Monte Carlo simulation was employed in the calculation since it was difficult to mathematically express the radon emanation fraction for the present soil model. Grain size is one of the most important factors in describing the properties of soil. Grain size was demonstrated to affect the radon emanation fraction, depending on moisture content. Although the emanation fraction is generally considered to be proportional to grain size, the result of the model calculation suggested that the effect of grain size is not so simple. This study should serve as an initial step toward improving the modeling of this radon emanation. (C) 2010 Elsevier Ltd. All rights reserved.

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  • Differences of natural radioactivity and radon emanation fraction among constituent minerals of rock or soil Reviewed

    Akihiro Sakoda, Yuichi Nishiyama, Katsumi Hanamoto, Yuu Ishimori, Yuki Yamamoto, Takahiro Kataoka, Atsushi Kawabe, Kiyonori Yamaoka

    Applied Radiation and Isotopes   68 ( 6 )   1180 - 1184   2010.6

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    We examined differences in the radioactive characteristics among the main minerals forming granite materials. Using a non-toxic high-density agent, minerals were separated from rock (granite-gneiss) and soil (weathered granite) samples. The natural radioactivity (U-238 and Ra-226) and radon emanation fraction of the minerals were then studied by gamma-ray spectrometry. The radon emanation fractions (27-43%) of the minerals from the soil were much higher than those (0.6-4.6%) of the rock minerals. Additionally, the emanation fractions differed greatly among the minerals separated from both the bulk rock and soil. These results were discussed in terms of the differences of surface area and radium distribution in the mineral grains. It was noticeable that a higher emanation fraction than expected for quartz was commonly observed in the rock and soil samples. We then estimated the contribution of each constituent mineral to the total radon exhalation from the bulk samples. The result depended not only on the radon emanation fraction, but also on the Ra-226 activity and the mineral content. Furthermore, using the obtained data, we also discussed the effect of grain size on radon emanation and why this has been reported to vary markedly in previous studies. (C) 2010 Elsevier Ltd. All rights reserved.

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  • Experimental and modeling studies of grain size and moisture content effects on radon emanation Reviewed

    Akihiro Sakoda, Yuu Ishimori, Katsumi Hanamoto, Takahiro Kataoka, Atsushi Kawabe, Kiyonori Yamaoka

    Radiation Measurements   45 ( 2 )   204 - 210   2010.2

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    Some models have already been developed to explain the effect of moisture content on the radon emanation fraction of soil. For this purpose, "microscopic" soil models, which are easy to deal with mathematically but cannot take grain size into consideration, have been designed. These previous models consist basically of two opposite grain surfaces and pores between the grains. In the present study, in order to study the effect of not only moisture content but also grain size, we present a simple modeling approach based on two "macroscopic" soil models: (1) a single-grain model and (2) a multiple-grain model. The latter model represents a configuration of spherical grains packed in a simple cubic structure. Based on these soil models and general assumptions, the radon emanation fraction was calculated as a function of grain size or moisture content by Monte Carlo simulation. The results for the multiple-grain model show that the radon emanation fraction is markedly increased with grain sizes ranging from 10 to 100 inn and reaches a constant value of 50% when moisture content is 0% and the radium is uniformly distributed on the grain surface. Moreover, a drastic increase is seen at smaller grain sizes with increasing moisture content. From these results, we concluded that the calculation of radon emanation depends greatly on the pore size between a Ra-bearing grain and a neighboring grain. The validity of the model was also evaluated by comparison to experimental data. (C) 2010 Elsevier Ltd. All rights reserved.

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  • Basic Study on Active Changes in Biological Function of Mouse Liver Graft in Cold Storage after Low-Dose X-Irradiation Reviewed

    Takahiro Kataoka, Masaaki Yoshimoto, Shinya Nakagawa, Yuko Mizuguchi, Takehito Taguchi, Kiyonori Yamaoka

    Journal of Clinical Biochemistry and Nutrition   45 ( 2 )   219 - 226   2009.9

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    We previously reported that low-dose X-irradiation alleviates ischemia-reperfusion injury such as mouse paw edema. In this study, we examined active changes in the biological function of mouse liver grafts in cold storage after low-dose X-irradiation. Mouse livers were sham-irradiated or were irradiated with 0.25, 0.5, 1.0, or 5.0 Gy of X-ray and stored for 4, 8, 24, or 48 h in preservation or saline solution. The results show that storage for 24 h in saline solution after 0.5 Gy irradiation significantly increased the activity of superoxide dismutase (SOD) and catalase. Following storage for 4, 8, or 48 h in preservation solution, lipid peroxide levels of the 0.5 Gy irradiated group were significantly lower than those of the sham irradiated group. Following storage for 24 h in preservation solution, the activity of SOD and catalase of the 1.0 Gy irradiated group were significantly higher than those of the sham irradiated group. Hepatocytes stored in saline solution were vacuolated. However, no vacuole formation was observed in hepatocytes stored in preservation solution. These findings suggest that low-dose irradiation significantly activates antioxidative functions of liver grafts. Moreover, the dose at which enhancement of antioxidative function occurs in livers stored in preservation solution, which contains glutathione, is significantly higher than that in saline solution.

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  • No different sensitivity in terms of whole-body irradiation between normal and acatalasemic mice Reviewed

    Shinya Nakagawa, Takahiro Kataoka, Yuko Mizuguchi, Masaaki Yoshimoto, Akihiro Sakoda, Takaharu Nomura, Da-Hong Wang, Atsushi Kawabe, Takehito Taguchi, Kiyonori Yamaoka

    Journal of Clinical Biochemistry and Nutrition   43 ( 1 )   41 - 49   2008.7

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    To elucidate the radiosensitivity of an acatalasemic mouse, we examined the time and dose-dependency in the survival rates, the lymphocytes and the intestinal epithelial cells, and the antioxidant function after 3.0 to 12.0 Gy whole body irradiation. Results showed that no significant differences between acatalasemic mice and normal mice were observed in the survival rates and the histological changes in spleens and small intestine after each irradiation. The catalase activities in livers and spleens of acatalasemic mice were significantly lower than those of normal mice and the glutathione peroxidase activity in livers of acatalasemic mice was significantly higher than that of normal mice. At 10 days after 6.0 Gy irradiation, the catalase activities in livers of acatalasemic and normal mice and that in spleens of normal mice significantly decreased compared with no-irradiation control, and there were no differences between those catalase activities. The total glutathione content in acatalasemic mice was significantly higher than that in normal mice at 10 days after 6.0 Gy irradiation. These findings suggested that the radiosensitivity of acatalasemic mice in terms of whole body irradiation doesn't significantly differ from that of normal mice, probably due to compensated sufficient contents of glutathione peroxidase and total glutathione in acatalasemic mice.

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  • Radioactivity and radon emanation fraction of the granites sampled at Misasa and Badgastein Reviewed International journal

    Akihiro Sakoda, Katsumi Hanamoto, Yuu Ishimori, Tomohiro Nagamatsu, Kiyonori Yamaoka

    Applied Radiation and Isotopes   66 ( 5 )   648 - 652   2008.5

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    The chemical composition was analyzed and the radioactivity, radon exhalation rate and emanation fraction were measured to investigate the characteristics of the granites sampled at Misasa and Badgastein, world famous for radon therapy. The Misasa granite was probably composed of quartz, albite and microcline. The Badgastein granite was probably composed of quartz and muscovite. The radon exhalation rates and emanation fractions of the Misasa granite were much higher than those of the Badgastein granite, regardless of the (226)Ra activity concentrations. (C) 2007 Elsevier Ltd. All rights reserved.

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  • Effects of some physical conditions on leaching rate of radon from radioactive minerals originating from some hot springs Reviewed

    Akihiro Sakoda, Katsumi Hanamoto, Yuu Ishimori, Tomohiro Nagamatsu, Kiyonori Yamaoka

    Radiation Measurements   43 ( 1 )   106 - 110   2008.1

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    In order to determine the best physical conditions for leaching more radon from minerals into water, we measured the leaching rate of radon from radioactive minerals under the conditions of some different grain sizes and water temperatures. Water temperature affected the leaching rate of radon although the grain size did not significantly affect it. Furthermore, we proposed ultrasonic irradiation to the mixture of a mineral and water as the method of leaching more radon. Ultrasonic irradiation was efficient to leach more radon from the mineral soaked in water because of ultrasonic cavitation. (C) 2007 Elsevier Ltd. All rights reserved.

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  • Inhibitory effects of prior low-dose X-irradiation on ischemia-reperfusion injury in mouse paw Reviewed International journal

    Takahiro Kataoka, Yuko Mizuguchi, Masaaki Yoshimoto, Takehito Taguchi, Kiyonori Yamaoka

    Journal of Radiation Research   48 ( 6 )   505 - 513   2007.11

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    We have reported that low-dose, unlike high-dose, irradiation enhanced antioxidation function and reduced oxidative damage. On the other hand, ischemia-reperfusion injury is induced by reactive oxygen species. In this study, we examined the inhibitory effects of prior low-dose X-irradiation on ischemia-reperfusion injury in mouse paw. BALB/c mice were irradiated by sham or 0.5 Gy of X-ray. At 4 hrs after irradiation, the left hind leg was bound 10 times with a rubber ring for 0.5, 1, or 2 hrs and the paw thickness was measured. Results show that the paw swelling thickness by ischemia for 0.5 hr was lower than that for 2 hrs. At I hr after reperfusion from ischemia for I hr, superoxide dismutase activity in serum was increased in those mice which received 0.5 Gy irradiation and in the case of the ischemia for 0.5 or I hr, the paw swelling thicknesses were inhibited by 0.5 Gy irradiation. In addition, interstitial edema in those mice which received 0.5 Gy irradiation was less than that in the mice which underwent by sham irradiation. These findings suggest that the ischemia-reperfusion injury is inhibited by the enhancement of antioxidation function by 0.5 Gy irradiation.

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  • A comparative study on the characteristics of radioactivities and negative air ions originating from the minerals in some radon hot springs Reviewed International journal

    Akihiro Sakoda, Katsumi Hanamoto, Naoto Haruki, Tomohiro Nagamatsu, Kiyonori Yamaoka

    Applied Radiation and Isotopes   65 ( 1 )   50 - 56   2007.1

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    To elucidate the characteristics of some radon hot springs, we simulated a hot spring by soaking the rocks for the radon therapy in water and measured the concentrations of radon and negative air ions in various conditions. In the results, the individual rock structure could contribute to radon leaching because the radon leaching rates were independent of the grain sizes. More negative air ions were generated by the wet rocks than by the dry rocks. (c) 2006 Elsevier Ltd. All rights reserved.

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  • Activation of antioxidant system by low dose radiation and its applicable possibility for treatment of reactive oxygen species-related diseases Invited Reviewed

    Kiyonori Yamaoka

    Journal of Clinical Biochemistry and Nutrition   39 ( 3 )   114 - 133   2006.11

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    We clarified that adequate oxygen stress induced by low dose irradiation activates not only chemical biological protective function, such as induction of the synthesis of superoxide dismutase, glutathione peroxidase, and heat shock protein 70, but also the biomembrane function, such as enhanced membrane fluidity and ATPase activity. It is possible that activation of these mechanisms alleviates in vivo oxidation injuries resulting in alleviation of pathologic condition, such as symptoms of hepatopathy and diabetes mellitus. Namely, adequate activation of the functions of the living body by low dose irradiation can contribute to suppressing aging and to preventing or reducing reactive oxygen species related diseases which are thought to involve peroxidation and have been regarded as the diseases for which radon spring water is an effective treatment. Clarification in detail of the mechanisms of these phenomena is required to understand the effects of low dose irradiation or radon inhalation on the functions of the living body, including adaptive response.

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  • Histological changes in spleens of radio-sensitive and radio-resistant mice exposed to low-dose X-ray irradiation Reviewed International journal

    Takahiro Kataoka, Yuko Mizuguchi, Kenji Notohara, Takehito Taguchi, Kiyonori Yamaoka

    Physiological Chemistry and Physics and Medical NMR   38 ( 1 )   21 - 29   2006

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    We have previously determined by using immune-assay or bio-assay methods that low-dose irradiation enhances immune and anti-oxidation functions. In this study, we examined histological changes of lymphatic follicles at 4, 24, or 48 hrs after sham, 0.25, 0.5, or 15 Gy irradiation in the spleens of BALB/c mice, which are sensitive to radiation compared with other strains, and C57BL/6J mice, which are resistant to radiation, using hematoxylin-eosin staining for lymphatic follicles or methylgreen pyronin staining for plasma cells. Results show that the lymphatic follicles in the spleens of the two mouse strains decreased at 24 or 48 hrs after 15 Gy irradiation. The number of plasma cells in the spleens of sham irradiated BALB/c mice was greater than that of sham irradiated C57BL/6J mice. At 4 hrs after 0.25 Gy irradiation, plasma cells increased in the spleens of the two mouse strains. These findings suggest, by histology, that low-dose irradiation activates the plasma cells and enhances the immune function. Although those two mouse strains have different sensitivities to radiation, the above changes were similar in both time course and degree of response. Therefore, the phenomena observed may be common in mice.

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  • Basic study on biochemical mechanism of thoron and thermal therapy Reviewed International journal

    Takahiro Kataoka, Yutaka Aoyama, Akihiro Sakoda, Shinya Nakagawa, Kiyonori Yamaoka

    Physiological Chemistry and Physics and Medical NMR   38 ( 2 )   85 - 92   2006

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    Exposure to water in hot springs containing thoron is thought to exercise beneficial effects on hypertension and diabetes mellitus. To put to a test this hypothesis we examined the time dependent changes in the levels of lipid peroxide, vasoactive- and diabetes associated substances in human blood in order to throw further light on the possible beneficial influence of thoron and thermal therapy on the mechanism of hypertension and diabetes mellitus. Every 2 days, nasal inhalation of vapor containing thoron was performed for 40 min. Blood samples were collected after each treatment at 1,2, and 3 weeks after the first treatment. Results show that the treatment decreased the lipid peroxide levels. The finding suggests that the treatment contributes to the prevention of peroxidation reaction related to hypertension and diabetes mellitus. Moreover, the changes in vasoactive-associated substances indicate an increase in tissue perfusion, suggesting that the treatment plays a role in alleviating hypertension. The treatment decreased the total ketone body levels and the finding suggests that the treatment contributes to the prevention of diabetes mellitus related to the insulin deficiency.

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  • The elevation of p53 protein level and SOD activity in the resident blood of the Misasa radon hot spring district Reviewed International journal

    K Yamaoka, F Mitsunobu, S Kojima, M Shibakura, T Kataoka, K Hanamoto, Y Tanizaki

    Journal of Radiation Research   46 ( 1 )   21 - 24   2005.3

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    To clarify the mechanism by which radon hot springs prevent cancer or not, in this study, blood was collected from residents in the Misasa hot spring district and in a control district. The level of a representative cancer-suppressive gene, p53, and the activity of a representative antioxidant enzyme, superoxide dismutase (SOD), were analyzed as indices. The level of serum p53 protein in the males in the Misasa hot spring district was found to be 2-fold higher than that in the control district, which is a significant difference. In the females in the Misasa hot spring district, SOD activity was approximately 15% higher than that in the control district, which is also statistically significant, and exceeded the reference range of SOD activity despite advanced age. These results suggested that routine exposure of the residents in the Misasa hot spring district to radon at a concentration about 3 times higher than the national mean induces trace active oxygen in vivo, potentiating products of cancer- suppressive gene and antioxidant function. As the p53 protein level was high in the residents in the Misasa hot spring district, apoptosis of cancer cells may readily occur.

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  • A comparative study on radioactive characteristics of the minerals for radon therapy Reviewed

    K Hanamoto, K Yamaoka

    Radiation Measurements   39 ( 2 )   157 - 160   2005.2

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    To elucidate the mechanism of the radon therapy, we analyzed the radioactive characteristics of the minerals in the famous regions for the radon therapy. Using a high-purity germanium detector, we measured the sludge at the hot bathroom with a high concentration of radon at Misasa Medical Center of Okayama University Medical School, the hokutolite, which was the same kind of mineral at Tamagawa Hot Spring in Japan, and the mineral at the gallery of Badgastein in Austria, which are celebrated regions for the radon therapy. As a result, the ratios of the uranium series to the thorium series for the sludge of Misasa, the hokutolite, and the mineral of Badgastein were 22, 50, and 0.94, respectively. The sludge of Misasa and the hokutolite mainly included the radioelements of the uranium series, while the mineral of Badgastein included the radioelements of both series with almost the same ratio. The ratio of the mineral of Badgastein is similar to that of background (1.1). Furthermore, two kinds of minerals, which are commercially available for radon therapy, were measured using the same detector. The ratios for the two minerals were 0.26 and 0.20, namely, the two minerals included larger radioelements of the thorium series than those of the uranium series. (C) 2004 Elsevier Ltd. All rights reserved.

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  • Effects of post low-dose X-ray irradiation on carbon tetrachloride-induced acatalasemic mice liver damage Reviewed International journal

    Takahiro Kataoka, Takaharu Nomura, Da-Hong Wang, Takehito Taguchi, Kiyonori Yamaoka

    Physiological Chemistry and Physics and Medical NMR   37 ( 2 )   109 - 126   2005

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    The catalase activities in the blood and organs of the acatalasemic (C3H/AnLCsb-Csb) mouse of the C3H strain are lower than those of the normal (C3H/AnLCsa-Csa) mouse. We examined the effects of post low-dose (0.5 Gy) X-ray irradiation which reduced the oxidative damage under carbon tetrachloride-induced hepatopathy in acatalasemic or normal mice. As a result, the 0.5 Gy irradiation after carbon tetrachloride administration decreased the glutamic oxaloacetic and glutamic pyruvic transaminase activity in the acatalasemic mouse blood to a level similar to that of the acatalasemic mouse blood not treated with carbon tetrachloride
    this is in contrast to a high-dose (15 Gy) irradiation. In the same manner, pathological disorder was improved by 0.5 Gy irradiation. The fat degeneration in normal mice was quickly reduced, in contrast to acatalasemic mice. These findings suggest that low-dose irradiation after carbon tetrachloride administration accelerates the rate of recovery and that catalase plays an important role in the recovery from hepatopathy induced by carbon tetrachloride, in contrast to high-dose irradiation.

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  • Biochemical comparison between radon effects and thermal effects on humans in radon hot spring therapy Reviewed International journal

    K Yamaoka, F Mitsunobu, K Hanamoto, K Shibuya, S Mori, Y Tanizaki, K Sugita

    Journal of Radiation Research   45 ( 1 )   83 - 88   2004.3

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    The radioactive and thermal effects of radon hot spring were biochemically compared under a sauna room or hot spring conditions with a similar chemical component, using the parameters that are closely involved in the clinic for radon therapy. The results showed that the radon and thermal therapy enhanced the antioxidation functions, such as the activities of superoxide dismutase (SOD) and catalase, which inhibit lipid peroxidation and total cholesterol produced in the body. Moreover the therapy enhanced concanavalin A (ConA)-induced mitogen response and increased the percentage of CD4 positive cells, which is the marker of helper T cells, and decreased the percentage of CD8 positive cells, which is the common marker of killer T cells and suppressor T cells, in the white blood cell differentiation antigen (CD8/CD4) assay. Furthermore, the therapy increased the levels of a atrial natriuretic polypeptide (alphaANP), beta endorphin, adrenocorticotropic hormone (ACTH), insulin and glucose-6-phosphate dehydrogenase (G-6-PDH), and it decreased the vasopression level. The results were on the whole larger in the radon group than in the thermal group. The findings suggest that radon therapy contributes more to the prevention of life-style-related diseases related to peroxidation reactions and immune suppression than to thermal therapy. Moreover, these indicate what may be a part of the mechanism for the alleviation of hypertension, osteoarthritis (pain), and diabetes mellitus brought about more by radon therapy than by thermal therapy.

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  • Inhibitory effects of prior low-dose X-ray irradiation on carbon tetrachloride-induced hepatopathy in acatalasemic mice Reviewed International journal

    K Yamaoka, T Kataoka, T Nomura, T Taguchi, DH Wang, S Mori, K Hanamoto, S Kira

    Journal of Radiation Research   45 ( 1 )   89 - 95   2004.3

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    The catalase activities in blood and organs of the acatalasemic (C3H/AnLCs(b)Cs(b)) mouse of C3H strain are lower than those of the normal (C3H/AnLCs(a)Cs(a)) mouse. We examined the effects of prior low-dose (0.5 Gy) X-ray irradiation, which reduced the oxidative damage under carbon tetrachloride-induced hepatopathy in the acatalasemic or normal mice. The acatalasemic mice showed a significantly lower catalase activity and a significantly higher glutathione peroxidase activity compared with those in the normal mice. Moreover, low-dose irradiation increased the catalase activity in the acatalasemic mouse liver to a level similar to that of the normal mouse liver. Pathological examinations and analyses of blood glutamic oxaloacetic and glutamic pyruvic transaminase activity and lipid peroxide levels showed that carbon tetrachloride induced hepatopathy was inhibited by low-dose irradiation. These findings may indicate that the free radical reaction induced by the lack of catalase and the administration of carbon tetrachloride is more properly neutralized by high glutathione peroxidase activity and low-dose irradiation in the acatalasemic mouse liver.

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  • Study on biological effects of radon and thermal therapy on osteoarthritis Reviewed International journal

    K Yamaoka, F Mitsunobu, K Hanamoto, S Mori, Y Tanizaki, K Sugita

    Journal of Pain   5 ( 1 )   20 - 25   2004.2

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    Radon therapy uses radon (Rn-222) gas, which mainly emits alpha-rays and induces a small amount of active oxygen in the body. We first examined the temporal changes in antioxidants, immune, vasoactive, and pain-associated substances in human blood by therapy to elucidate the mechanism of osteoarthritis in which radon therapy is used as a treatment. Results showed that radon inhalation enhanced the antioxidation and immune function, and the findings suggest that radon therapy contributes to the prevention of osteoarthritis related to peroxidation reactions and immune depression. Moreover, the changes in vasoactive and pain-associated substances indicated increases in tissue perfusion brought about by radon therapy, suggesting that radon inhalation plays a role in alleviating pain.
    Perspective: The findings suggest that an appropriate amount of active oxygen is produced in the body after radon inhalation, and this contributes to the alleviation of the symptoms of active oxygen diseases such as osteoarthritis. (C) 2004 by the American Pain Society.

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  • 展望 ラドン療法の適応症とその機構解明の現状 Invited Reviewed

    山岡聖典

    Isotope News   588   2 - 8   2003.4

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  • Elevation of glutathione induced by low-dose gamma rays and its involvement in increased natural killer activity Reviewed International journal

    S Kojima, H Ishida, M Takahashi, K Yamaoka

    RADIATION RESEARCH   157 ( 3 )   275 - 280   2002.3

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    We examined the relationship between the induction of an increase in the level of glutathione and the elevation of natural killer (NK) activity in mouse splenocytes by a low dose of 7 rays. The glutathione levels in mouse splenocytes increased significantly between 2 h and 6 h after whole-body 7 irradiation at 0.5 Gy, peaked at 4 h, and then decreased almost to the level before irradiation by 12 h postirradiation. A significant enhancement of NK activity was found in the splenocytes obtained from whole-body-irradiated mice between 4 and 6 h postirradiation. Reduced glutathione (GSH) added exogenously to splenocytes obtained from normal mice enhanced both the total cellular glutathione content and the NK activity in a dose-dependent manner. Other precursors of de novo GSH synthesis, such as cysteine, N-acetylcysteine and oxidized glutathione, also increased the activity. These enhancements were completely blocked by buthionine sulfoximine, an inhibitor of de novo GSH synthesis. We conclude that the induction of endogenous glutathione in living cells immediately after low-dose T irradiation is at least partially responsible for the appearance of enhanced NK activity. (C) 2002 by Radiation Research Society.

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  • Elevation of antioxidant potency in mice brain by low-dose X-ray irradiation and its effect on Fe-NTA-induced brain damage Reviewed International journal

    Kiyonori Yamaoka, Shuji Mori, Takaharu Nomura, Takehito Taguchi, Takehiko Ito, Katsumi Hanamoto, Shuji Kojima

    Physiological Chemistry and Physics and Medical NMR   34 ( 2 )   119 - 132   2002

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    The increase in lipid peroxide levels in mice brain following Fe 3+ administration was about 50% of that when 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine (MPTP) was administered. This may be due to excessive oxidation by Fe3+, and was supported by the decrease in activities of antioxidant enzymes, such as superoxide dismutase (SOD), catalase and glutathione peroxidase (GPX), Na+,K+-ATPase activity and membrane fluidity after Fe3+ administration. Relatively low-dose X-ray irradiation (0.5 Gy) inhibited lipid peroxidation associated with Fe 3+ administration and restored the decreased activities of the above antioxidant enzymes and Na+K+-ATPase, and membrane fluidity to the levels in the non-Fe3+-administered group. In the purine metabolism system, uric acid decreased after Fe3+ administration, which may be due to transient impairment of the system for production of uric acid from xanthine by excessive oxidation by Fe3+. However, 0.5 Gy irradiation inhibited this decrease in uric acid, increasing its level to that in the non Fe3+-administrated group. This may be due to factors such as rapid recovery of the activities of the above antioxidant enzymes and Na+,K+-ATPase, and membrane fluidity after 0.5 Gy irradiation. In addition, since no changes were observed in xanthine and uric acid, increased inosine and hypoxanthine may have advanced to a salvage pathway leading to not xanthine but inosine 5′-monophosphate (IMP).

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  • Adjustment function among antioxidant substances in acatalasemic mouse brain and its enhancement by low-dose x-ray irradiation Reviewed International journal

    Kiyonori Yamaoka, Takaharu Nomura, Da-Hong Wang, Shuji Mori, Takehito Taguchi, Tetsuya Ishikawa, Katsumi Hanamoto, Shohei Kira

    Physiological Chemistry and Physics and Medical NMR   34 ( 2 )   133 - 144   2002

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    The catalase activities in blood and organs of the acatalasemic (C3H/AnLCsbCsb) mouse of the C3H strain are lower than those of the normal (C3H/AnLCsaCsa) mouse. We conducted a study to examine changes in the activities of antioxidant enzymes, such as catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPX), the total glutathione content, and the lipid peroxide level in the brain, which is more sensitive to oxidative stress than other organs, at 3, 6, or 24 hr following X-ray irradiation at doses of 0.25, 0.5, or 5.0 Gy to the acatalasemic and the normal mice. No significant change in the lipid peroxide level in the acatalasemic mouse brain was seen under non-irradiation conditions. However, the acatalasemic mouse brain was more damaged than the normal mouse brain by excessive oxygen stress, such as a high-dose (5.0 Gy) X-ray. On the other hand, we found that, unlike 5.0 Gy X-ray, a relatively low-dose (0.5 Gy) irradiation specifically increased the activities of both catalase and GPX in the acatalasemic mouse brain making the activities closer to those in the normal mouse brain. These findings may indicate that the free radical reaction induced by the lack of catalase is more properly neutralized by low dose irradiation.

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  • Basic Study on Radon Effects and Thermal Effects on Humans in Radon Therapy Reviewed

    Kiyonori Yamaoka, Takashi Mifune, Fumihiro Mitsunobu, Shuji Kojima, Shuji Mori, Koichi Shibuya, Yoshiro Tanizaki, Katsuhiko Sugita

    Physiological Chemistry and Physics and Medical NMR   33 ( 2 )   133 - 138   2001

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    Because most of the diseases to which radon (222Rn) therapy is applied are related to activated oxygen, in this study the effect of the radioactivity of radon and the thermal effect were compared under a room or a hot spring condition with the same chemical component using as the parameters the activity of superoxide dismutase (SOD), which is an oxidation inhibitor, and lipid peroxide and low density lipoprotein (LDL)-cholesterol, which are closely involved in arteriosclerosis. Results show that the SOD activity was significantly increased, and the lipid peroxide and LDL-cholesterol levels were significantly decreased on days 6 and 7 of study. The results were about 2-fold larger in the radon group than in the thermo group. This suggests that the anti-oxidation function was more enhanced by radon therapy than by thermo therapy, and suggests that radon therapy may help to prevent the causes of life style-related diseases such as arteriosclerosis. These findings are important in understanding the mechanism of diseases in which radon therapy is used as treatment, and most of which are called activated oxygen-related diseases.

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  • Possible role of elevation of glutathione in the acquisition of enhanced proliferation of mouse splenocytes exposed to small-dose gamma-rays Reviewed

    Kojima Shuji, Shiramine Matsumori, Hideki Ishida, Kiyonori Yamaoka

    International Journal of Radiation Biology   76 ( 12 )   1641 - 1647   2000.12

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    Purpose: To examine the relation between the induction of an increased glutathione level and the elevated proliferative response of mouse splenocytes by a small dose of gamma -rays.
    Materials and methods: Male ICR strain mice, 7 weeks of age, were divided into irradiated and non-irradiated control groups. irradiation was done with gamma -rays from a Cs-137 source at a dose of 50 cGy (1.11 Gy/min). Glutathione content in the splenocytes was measured using a modified spectrophotometric technique. Concanavalin A (Con A)-induced proliferative response of the splenocytes after whole-body gamma -ray irradiation was estimated from the H-3-thymidine incorporation into the cells.
    Results: The glutathione level in mouse splenocytes increased 2 h after whole-body gamma -ray irradiation at 50 cGy, peaked at 4-h and thereafter decreased almost to the zero-time level by 12-h postirradiation. A significant enhancement of Con A-induced proliferation was observed in the splenocytes obtained from the whole-body-irradiated animals between 2 h and 6 h post-irradiation. Glutathione exogenously added to splenocytes obtained from normal mice enhanced the Con A-induced proliferation of splenocytes in a dose-dependent manner. This enhancement was completely blocked by buthionine sulfoximine, a specific inhibitor of the de novo pathway of glutathione synthesis.
    Conclusions: The induction of endogenous glutathione immediately after low-dose gamma -ray irradiation is at least partially responsible for the enhancement of immune function, and may throw light on the mechanisms of carcinostatic effects induced by low dose ionizing radiation.

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  • Mechanisms involved in the elevation of glutathione in RAW 264.7 cells exposed to low doses of gamma-rays Reviewed

    Kojima Shuji, Kazuo Teshima, Kiyonori Yamaoka

    Anticancer Research   20 ( 3A )   1589 - 1594   2000.5

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    We examined the mechanisms of the elevation of glutathione level induced in macrophage-like RAW 264.7 cells by low closes of gamma-rays. The level increased soon after exposure of the cells to 50 cGy of gamma-rays, peaked between 3 hours and 6 hours and rearmed almost to the time 0 value by 24 hours post-irradiation. Doses between 25 and 100 cGy significantly increased the glutathione level at 4 hours post-irradiation. However there was no significant elevation at doses of more than 100 cGy or less than 25 cGy. When the effect of dose I-ate was examined at a constant absorbed dose of 50 cGy, dose rates Of more than 50 cGy/minute significantly increased the GSH level at 4 hours post-irradiation. It was also shown that the elevation of glutathione level in cells irradiated with low doses of gamma-rays followed the induction of mRNA coding for gamma-glutamylcysteine synthetase (gamma-GCS) a rate-limiting enzyme of the de novo glutathione synthesis pathway When the cells were exposed to the radiation in the presence of genistein, calphostin C or nifedipine, the elevations of glutathione and gamma-GCS mRNA expression were both mostly blocked. EGTA also strongly inhibited these elevations. These results suggest that the tyrosine kinase, calcium channel and protein kinase C activities play an essential role in the law-dose-radiation-induced elevation of cellular glutathione.

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  • Inhibitory effects of post low dose gamma-ray irradiation on ferric-nitrilotriacetate-induced mice liver damage Reviewed

    K Yamaoka, S Kojima, T Nomura

    FREE RADICAL RESEARCH   32 ( 3 )   213 - 221   2000

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    We studied the effects of a single post whole-body low-dose irradiation (50 cGy of gamma-ray) on mice with ferric nitrilotriacetate (Fe3+-NTA)-induced transient hepatopathy. As a result, low-dose irradiation accelerated the rate of recovery. Based on the changes in glutamic oxaloacetic transaminase (GOT) activities, glutamic pyruvic transaminase (GPT) activities and lipid peroxide levels, it was shown that hepatopathy was improved by low-dose irradiation 3 h after Fe3+-NTA administration. This may be because of the enhancement of antioxidant agents such as total glutathione (GSH + GSSG), glutathione peroxidase (GPX), glutathione reductase (GR) and gamma-glutamylcysteine synthetase (gamma-GCS) by low-dose irradiation. These findings suggest that low-dose irradiation relieved functional disorders at least in the livers of mice with active oxygen species related diseases.

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  • Low-dose γ-ray Irradiation Reduces Oxidative Damage in Mouse Liver Induced by CCl4 Reviewed

    Takaharu Nomura, Kiyonori Yamaoka

    Free Radical Biology and Medicine   27 ( 11-12 )   1324 - 1333   1999.12

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    We examined the effects of irradiation (50 cGy of gamma-ray) reducing the oxidative damage in carbon tetrachloride (CCl4)-hepatopathy mice. We made pathological examinations and analyzed transaminase activity (glutamic oxaloacetic transaminase and glutamic pyruvic transaminase), lipid peroxide level and the activities of endogenous antioxidants in the mouse. The irradiation was found to accelerate the recovery. Based on pathological examination as well as changes in each transaminase activity and lipid peroxide levels, it was shown that hepatopathy improved 3 d after the irradiation. The activities of glutathione reductase and glutathione peroxidase rapidly elevated after irradiation, and the total glutathione content gradually increased in the irradiation group. Both activities of gamma-glutamylcysteine synthetase and catalase were higher than normal at all times after the irradiation and gradually increased. In addition, the gamma-glutamylcysteine synthetase activity changed In a similar fashion to the total glutathione content. However, superoxide dismutase activity in bath groups decreased and that of the irradiation group was significantly lower than that of the sham-irradiation group. These findings suggest that low-dose radiation relieved functional disorder at least in the liver of mice with active oxygen diseases. (C) 1999 Elsevier Science Inc.

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  • Elevation of glutathione in RAW 264.7 cells by low-dose gamma-ray irradiation and its responsibility for the appearance of radioresistance Reviewed

    Shuji Kojima, Shirane Matsumori, Hideki Ono, Kiyonori Yamaoka

    Anticancer Research   19 ( 6B )   5271 - 5275   1999.11

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    We examined the relationship between the induction of glutathione (GSH) level in macrophage-like RAW 264.7 cells by a low (adapting) dose gamma-rays and the cell damage caused by a lethal dose of gamma-rays at var-lolls intervals after the adapting dose. The reduced glutathione (GSH) level increased soon after exposure of the cells to 25 cGy of gamma-rays, peaked between 3 hl and 6 hr, and returned almost to the zero time (0 hr) bevel by 24 hr post-irradiation Cell damage was assessed by measuring the H-thymidine (H-3-TdR) incorporation into cellular DNA. gamma-Ray irradiation produced a dose- dependent cell damage in RAW cells, causing about 40% and 60% inhibition of H-3-TdR incorporation into DNA at 1.0 Gy and 2.0 Gy, respectively, as compared with non-irradiated cells. Treatment with the adapting dose of 25 cGy at I hr or 24 hr before the lethal irradiation was ineffective. However, pre-irradiation with 25 cGy at 3 hr or 6 hr prior to lethal irradiation inhibited the decrease of H-3-TdR incorporation into DNA, indicating a protective effect. GSH exogenously added to the medium also inhibited the cell damage induced by lethal doses of gamma-Rays in a dose-dependent manner. These results indicate that the induction of endogenous GSH in living cells immediately following low-dose gamma-Ray irradiation is at least partially responsible for the appearance of radioresistance to a subsequent lethal dose of radiation, and may make it possible to use higher doses of radiation in radiotherapy for tumor patients.

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  • Changes of SOD-like Substances in Mouse Organs after Low-dose X-ray Irradiation Reviewed

    Kiyonori Yamaoka, Shuji Kojima, Takahara Nomura

    Physiological Chemistry and Physics and Medical NMR   31 ( 1 )   23 - 28   1999

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    We demonstrated that low-dose irradiation with 50 cGy of X-ray induces in vivo production of superoxide dismutase (SOD)-like substances and accelerates antioxidant activity. To elucidate the defense mechanism against X-ray radiation, we examined which components among these SOD-like substances, such as SOD, vitamin C and celuroplasmin, are produced by low-dose irradiation. Our study revealed that SOD-like specific activity hardly involved SOD-like substances other than SOD. Moreover, it is suggested that low-dose irradiation induced synthesis and production of SOD itself, leading to elevation of SOD-specific activity.

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  • Induction of mRNAs for glutathione synthesis-related proteins in mouse liver by low doses of gamma-rays Reviewed

    S Kojima, O Matsuki, T Nomura, A Kubodera, Y Honda, S Honda, H Tanooka, H Wakasugi, K Yamaoka

    Biochimica et Biophysica Acta   1381 ( 3 )   312 - 318   1998.8

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    We examined the elevation of the reduced form of glutathione (GSH) level and the induction of mRNAs for proteins involved in the synthesis and regeneration of GSH in the liver of mice after low-dose gamma-ray irradiation. The liver GSH level increased soon after irradiation with 50 cGy of gamma-rays, reached a maximum at around 12 h post-treatment, The mRNA of gamma-glutamylcysteine synthetase (gamma-GCS), the rate-limiting enzyme for de novo synthesis for GSH, showed a small increase that peaked at 6 h after gamma-ray irradiation at a dose of 50 cGy. Only a small increase in gamma-GCS activity was observed throughout the 24-h post-irradiation period. In the case of glutathione reductase (GR), which is involved in the regeneration of GSH from the oxidized form (GSSG), the mRNA level peaked strongly at 1 h, while the activity peaked at twice the control level 12 h after irradiation. The level of mRNA for thioredoxin (TRX), which contributes to GSH biosynthesis by supplying cysteine to the de novo pathway, peaked at 1 h and declined thereafter, while the activity peaked at 3 h and then declined sharply. These results indicate that the increase in endogenous GSH immediately following low-dose gamma-ray irradiation is predominantly due to operation of the regeneration cycle and not de novo synthesis. We also examined the dependence of mRNA induction on the gamma-ray dose. (C) 1998 Elsevier Science B.V. All rights reserved.

    DOI: 10.1016/S0304-4165(98)00043-9

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  • Change of glutathione peroxidase synthesis along with that of superoxide dismutase synthesis in mice spleens after low-dose X-ray irradiation Reviewed

    K Yamaoka, S Kojima, M Takahashi, T Nomura, K Iriyama

    Biochimica et Biophysica Acta   1381 ( 2 )   265 - 270   1998.7

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    We have previously demonstrated that the activity of superoxide dismutase (SOD), an antioxidant, is enhanced by low-dose X-ray irradiation in various organs of animals such as rats. Since SOD is an enzyme that mediates the dismutation of O-2(-) to H2O2, the question as to whether the resultant H2O2 is further detoxicated into H2O and O-2 or not must still be evaluated. Hence, we studied the effect of low-dose X-ray irradiation on the synthesis of glutathione peroxidase (GSHPx), which is an antioxidant that catalyzes this reaction. The results suggest that H2O2 produced by increased SOD activity can be detoxicated into H2O and O-2 due to simultaneous enhancement of the GSHPx activity by X-ray irradiation at 20 cGy, in contrast to irradiation at 400 cGy. The results also show the enhancement in enzyme activities by induction of their synthesis shortly after irradiation at 20 cGy, Moreover, as this phenomenon was observed in BALB/c mice (which are more radiation-sensitive compared to other mouse strains) and radiation-resistant C57BL/6NJcl mice, it was considered to be a common phenomenon in the rat spleen. (C) 1998 Elsevier Science B.V. All rights reserved.

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  • Elevation of mouse liver glutathione level by low-dose gamma-ray irradiation and its effect on CCl4-induced liver damage Reviewed

    S Kojima, O Matsuki, T Nomura, A Kubodera, K Yamaoka

    Anticancer Research   18 ( 4A )   2471 - 2476   1998.7

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    We examined the elevation of glutathione (GSH) levels in the liver of C57BL/6 female mice after low-dose r-ray irradiation and its inhibitory effect on CCl4-induced liver damage. The liver GSH level increased soon after irradiation with 50 cGy of gamma-rays, reached a maximum at around 12 post-treatment, and returned almost to the control level by 24 h. The activities of glutathione reductase, and glutathione peroxidase also showed the same pattern of change, while the activity of gamma-glutamylcysteine synthetase showed a gradual increase up to 24 h. The effect of pre-irradiation on CCl4-induced liver damage was also investigated. The activities of glutamic oxaloacetic transaminase and glutamic pyruvic transaminase in serum were markedly increased 12 h post-treatment with CCl4. Both increases were significantly suppressed by a single low-dose pre-irradiation. Malondialdehyde, a marker of lipidperoxidation, was also greatly elevated after CCl4 treatment, and its increase was suppressed by irradiation. These results suggest low-dose gamma-ray irradiation might be effective for the prevention of and/or therapy of various reactive oxygen species-related diseases including cancer.

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  • Simultaneous quantitative analysis of prostaglandins and thromboxane after low-dose X irradiation Reviewed

    K Yamaoka, T Obata, K Iriyama, T Iwasaki, Y Hoshi

    Radiation Research   149 ( 1 )   103 - 106   1998.1

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    The appearance of prostaglandins and thromboxane in mouse serum after X irradiation was observed by simultaneous quantitative analysis using gas chromatography/mass spectrometry/selected ion monitoring with stable isotope dilution methods. Mice of two strains (C57BL/CN Jcl and BALB/c) showed similar responses to X irradiation. In C57BL/6N Jcl mice, 0.2 Gy irradiation elicited a significant increase in generation of prostanoids: Immediately after irradiation, the 6-keto PGF(1) alpha:TXB2 ratio and the level of PGE(2) increased, after 20 min 6-keto PGF(1) alpha and PGE(2) increased, and after 4 h PGE(1) and PGE(2) increased. In BALB/c mice, generation of prostanoids was increased significantly immediately after irradiation (6-keto PGF(1) alpha, 6-keto PGF(1) alpha:TXB2 ratio, PGE(2)), and the increase was maintained from 20 min to 4 h (PGE(1), PGE(2)) after 0.2 Gy irradiation. In C57BL/6N Jcl mice, a significant increase in production of 9 alpha,11 beta-PGF(2) was observed at 20 min after irradiation. In BALB/c mice, a significant increase in 9 alpha,11 beta-PGF(2) was seen immediately after irradiation and was maintained for 20 min. In C57BL/6N Jcl mice, the level of 8-epi PGF(2) alpha was clearly increased 4 h after 4 Gy irradiation. A slight and slow increase was also seen after 0.2 Gy irradiation. In BALB/c mice, 8-epi PGF(2) alpha was increased significantly at 20 min and 4 h after 4 Gy irradiation. These results show that 0.2 Gy irradiation stimulates production of prostanoids related to the inflammatory response in mice. (C) 1998 by Radiation Research Society.

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  • Inhibitory effects of prior low dose X-ray irradiation on Fe3+-NTA-induced hepatopathy in rats Reviewed

    K Yamaoka, T Nomura, K Iriyama, S Kojima

    Physiological Chemistry and Physics and Medical NMR   30 ( 1 )   15 - 23   1998

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    Blood activities of hepatocellular enzymes such as lactate dehydrogenase (LDH), glutamic pyruvic transaminase (GPT) and glutamic oxalacetic transaminase (GOT) peaked at 12 hours after a single intraabdominal injection of ferric nitrilotriacetate (Fe3+-NTA) in rats. Enzymes such as alkaline phosphatase (ALP) and leucin amino peptidase (LAP) originating in the capillary bile ducts or bile secretory liver cells were also released into the blood between 6-24 hours after intraabdominal injection of Fe3+-NTA in rats. Furthermore, hyperoxidation of lipids occurred in rat hepatic cell membranes, reaching a peak 6 hours after intraabdominal injection of Fe3+-NTA. It was found that a single prior 0.5 Gy whole body X-ray irradiation significantly increased superoxide dismutase (SOD) activities and suppressed above-mentioned symptoms of transient hepatopathy in rats.

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  • Effects of Low Dose X-ray Irradiation on Purine Metabolism in Mouse Splenocytes Reviewed

    K.Yamaoka, E.Niki, M.Takahashi, K.Iriyama

    Physiological Chemistry & Physics and Medical NMR   29 ( 1 )   1 - 10   1997

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    This study examines the influence of low dose X-ray irradiation on purine nucleotide metabolites such as adenosine, inosine, hypoxanthine, xanthine and uric acid, and hence generation of ATP-mediated energy in mouse splenocytes. It was found that, unlike high dose irradiation which promotes membrane damage, low dose irradiation enhances the ability to regulate the energy metabolisms as reflected by the increase in Na+, K+-ATPase activity and the adequate activation of the above salvage pathway. Namely, the levels of adenosine, inosine and uric acid significantly increased, while the levels of xanthine and hypoxanthine decreased significantly. Moreover, the cysteine level and Superoxide dismutase activity significantly increased at a dosage of 20 cGy.

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  • 低線量放射線による化学的生体防御機構の活性化と生体内酸化傷害の緩和 Invited Reviewed

    山岡聖典

    フリーラジカルの臨床   11   31 - 37   1997

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  • Research on the activation of chemical biological defense mechanism and the alleviation of in vivo oxidative damage by small amounts of active oxygen Reviewed

    Kiyonori Yamaoka

    Waseda University Doctoral Thesis (Science)   1996.2

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  • Experimental Study of Alleviation of Hypertation, Diabetes and Pain by Radon Inhalation Reviewed

    K.Yamaoka, Y.Komoto

    Physiological Chemistry & Physics and Medical NMR   28 ( 1 )   1 - 5   1996

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    Indications for treatment at the Misasa Hot Spring, a radon producing radioactive spring, include hypertension, diabetes mellitus and pain. To clarify its mechanisms of action on these conditions, we evaluated dynamic changes in blood components such as vasoactive substances after radon inhalation. Vasodilation, alleviation of diabetic symptoms and morphine-like analgesic effects were observed, suggesting that these changes constitute part of the mechanisms of the radon spring therapy on the above conditions.

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  • Biological Defense Mechanisms Invited Reviewed

    27   97 - 112   1996

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  • Study on effects of low dose radiation on physiological function Invited Reviewed

    16 ( 3 )   333 - 344   1995.7

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  • Effects of Low-Dose γ-irradiation to the Chest Regions on the Blood Pressure of Spontaneous Hypertensive Rat Reviewed

    K.Yamaoka, K.Ishii

    Physiological Chemistry & Physics and Medical NMR   27 ( 3 )   161 - 165   1995

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    We examined changes in the blood pressure and the superoxide dismutase (SOD) activities in aortic tissue after gamma-irradiation to the chest regions of spontaneous hypertensive rats (SHR) and Wistar Kyoto rats (WKY), and obtained the following results. After 5 Gy irradiation, there was no change with time in the blood pressure in WKY rats, while a transient decrease (3 days later) was observed in SHR rats. The Cu/Zn-SOD activity in the aorta of SHR was less than that of WKY. 5 Gy irradiation induced an increase in the Cu/Zn-SOD activity in SHR nearly to the level observed in WKY, which remained unchanged upon irradiation. Therefore, unlike high-dose irradiation, irradiation at a relatively low-dose of 5 Gy to SHR appears to increase the aortic Cu/Zn-SOD activity, which is lacking in SHR, leading to a decrease in the blood pressure.

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  • Study on effects of low dose radiation on biological function (3 subtitles) Reviewed

    Kiyonori Yamaoka

    Okayama University Doctoral Thesis (Medicine)   1994.3

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  • Changes in Specific Amino Acid Residues and Na+,K+-ATPase Activity in Cell Membranes of Rat Cerebral Cortex by Low Dose X-irradiation Reviewed

    K.Yamaoka, K.Ishii, R.Edamatsu, T.Ito, A.Mori

    Physiological Chemistry & Physics and Medical NMR   26 ( 4 )   323 - 328   1994

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  • Induction of Two Species of Superoxide Dismutase in Some Organs of Rats by Low Dose X-irradiation Reviewed

    K.Yamaoka, E.F.Sato, K.Utsumi

    Physiological Chemistry & Physicsand Medical NMR   26 ( 3 )   205 - 214   1994

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    Four hours after 0.25 Gy X-irradiation, the enzymatic activity of copper and zinc activated superoxide dismutase (Cu/Zn-SOD) in the spleen of mature rats showed a significant quantitative increase (by 25%); this was accompanied by a marked increase (by 70%) in the mRNA for this enzyme as compared to the control (sham irradiation) group. Irradiation had no effect on the enzymatic activity of manganese activated superoxide dismutase (Mn-SOD). Moreover, the expression of the mRNA for Mn-SOD was similar to that of the unirradiated control group. On the other hand, the enzymatic activity of both Cu/Zn-SOD and Mn-SOD in the liver of fetal rats showed a significant quantitative increase (by 15-35%); the expression of the mRNA for the two species of SOD increased (by 20-30%) at 4 hours after 1 Gy X-irradiation as compared to the control group. These findings suggest that the increase in SODmRNA level is due to novel transcription of SODmRNA by low dose irradiation.

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  • Effects of Low Dose X-irradiation on Biomembrane in Brain Cortex of Aged Rats Reviewed

    K.Yamaoka, R.Edamatsu, T.Ito, A.Mori

    Free Radical Biology & Medicine   16 ( 4 )   529 - 534   1994

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  • Effects of Radon Inhalation on Biological Function-Lipid Peroxide, SOD Activity and Membrane Fluidity- Reviewed

    K.Yamaoka, Y.Komoto, I.Suzuka, R.Edamatsu, A.Mori

    Archives of Biochemistry and Biophysics   302 ( 1 )   37 - 41   1993.4

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    We administered radon (Rn) to rabbits by inhalation and examined changes in the lipid peroxide (TBARS) level, superoxide dismutase (SOD) activity, and membrane fluidity in various organs to clarify the therapeutic effects of Rn. The lipid peroxide level of the brain was significantly decreased immediately after Rn inhalation for 90 min in both the low concentration group (about 7 ~ 10 kBq/liter) and the high concentration group (about 14 ~ 18 kBq/liter) as compared with that in the control group. It further decreased in the low concentration group but slightly recovered in the high concentration group 2 h after inhalation. The lipid peroxide level of the lung showed no change immediately after inhalation but decreased significantly in both groups 2 h after inhalation. With regard to SOD activity in the brain and lung, only that in the brain showed significant increase in the high concentration group immediately after inhalation; no other change was observed. Membrane fluidity, especially the fluidity of membrane protein, was significantly increased in the brains of both groups immediately after inhalation, and that 2 h after inhalation in the lung was significantly increased in both groups. These findings suggest that the inhalation of Rn at Rn springs contributes to the prevention of brain disorders related to peroxidation reactions by promoting these physiologic changes. © 1993 Academic Press, Inc.

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  • 低線量放射線が過酸化脂質量,SOD活性,および膜流動性に及ぼす影響ーラドン温泉の適応症および老化抑制との関連に着目してー Reviewed

    山岡聖典, 枝松礼, 古元嘉昭, 鈴鹿伊智雄, 森 昭胤

    磁気共鳴と医学   4   82 - 89   1993.4

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  • Increased SOD Activities and Decreased Lipid Peroxides Levels in Rat Organs Induced by low Dose X-irradiation Reviewed

    K.Yamaoka, R.Edamatsu, A.Mori

    Free Radical Biology and Medicine   11 ( 3 )   299 - 306   1991

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    After a single exposure to doses ranging from 0.05 to 0.50 Gy, the SOD activities in immune organs of the irradiated rats, at 4 h after whole-body X irradiation, showed significant increases by 50 to 90% (hereinafter p &lt; 0.05) in comparison with the control groups. The dose in the brain and liver showed tendencies to increase by 30 to 50% for doses ranging from 0.50 to 2.50 Gy. The levels of TBARS (lipid peroxides) in immune organs decreased significantly by 20 to 50% in contrast with the control groups for doses ranging from 0.10 to 1.00 Gy. Decreases by 20 to 30% were observed in brains and livers for doses near 0.50 Gy. When the dose was 0.25 Gy, the SOD activities in the spleen showed a persistent radiation-induced increase for at least 12 weeks, livers for 8 weeks, brains and thymuses for 4 weeks, and bone marrows for about 1 week. The TBARS levels in the brain and thymus showed persistent decreases due to irradiation for at least 12 weeks, and those in bone marrows for 8 h.

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  • Changes in sulfur metabolism in mouse brains following radon inhalation Reviewed

    Norie Kanzaki, Akihiro Sakoda, Takahiro Kataoka, Lue Sun, Hiroshi Tanaka, Iwao Ohtsu, Kiyonori Yamaoka

    International Journal of Environmental Research and Public Health 19(17), 10750, 2022   2022.8

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  • Radon Solubility and Diffusion in the Skin Surface Layers Reviewed

    Akihiro Sakoda, Tsuyoshi Ishida, Takahahiro Kataoka, Norie Kanzaki, Hiroshi Tanaka, Fumihiro Mitsunobu, Kiyonori Yamaoka

    International Journal of Environmental Research and Public Health 19(13), 7761, 2022   2022.6

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    DOI: 10.3390/ijerph19137761

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  • A simple method for estimating the potential of the pyroelectric crystal surface Reviewed

    Katsumi Hanamoto, Takahiro Kataoka, Kiyonori Yamaoka

    Applied Radiation and Isotopes 185,110230, 2022   2022.4

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  • Dosimetry of radon progeny deposited on skin in air and thermal water Reviewed International journal

    Akihiro Sakoda, Yuu Ishimori, Norie Kanzaki, Hiroshi Tanaka, Takahiro Kataoka, Fumihiro Mitsunobu, Kiyonori Yamaoka

    Journal of Radiation Research   62 ( 4 )   634 - 644   2021.7

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    It is held that the skin dose from radon progeny is not negligibly small and that introducing cancer is a possible consequence under normal circumstances as there are a number of uncertainties in terms of related parameters such as activity concentrations in air and water, target cells in skin, skin covering materials, and deposition velocities. An interesting proposal has emerged in that skin exposure to natural radon-rich thermal water as part of balneotherapy can produce an immune response to induce beneficial health effects. The goal of this study was to obtain generic dose coefficients with a focus on the radon progeny deposited on the skin in air or water in relation to risk or treatment assessments. We thus first estimated the skin deposition velocities of radon progeny in air and thermal water based on data from the latest human studies. Skin dosimetry was then performed under different assumptions regarding alpha-emitting source position and target cell (i.e. basal cells or Langerhans cells). Furthermore, the impact of the radon progeny deposition on effective doses from all exposure pathways relating to ‘radon exposure’ was assessed using various possible scenarios. It was found that in both exposure media, effective doses from radon progeny inhalation are one to four orders of magnitude higher than those from the other pathways. In addition, absorbed doses on the skin can be the highest among all pathways when the radon activity concentrations in water are two or more orders of magnitude higher than those in air.

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  • The Effects of Low-Dose-Rate γ-irradiation on Forced Swim Test-Induced Immobility and Oxidative Stress in Mice. Reviewed

    Tetsuya Nakada, Takahiro Kataoka, Takaharu Nomura, Hina Shuto, Junki Yano, Shota Naoe, Katsumi Hanamoto, Kiyonori Yamaoka

    Acta medica Okayama   75 ( 2 )   169 - 175   2021.4

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    The forced swim test (FST) induces immobility in mice. Low-dose (high-dose-rate) X-irradiation inhibits FSTinduced immobility in mice due to its antioxidative function. We evaluated the effects of low-dose γ-irradiation at a low-dose-rate on the FST-induced depletion of antioxidants in mouse organs. Mice received whole-body low-dose-rate (0.6 or 3.0 mGy/h) of low-dose γ-irradiation for 1 week, followed by daily FSTs (5 days). The immobility rate on day 2 compared to day 1 was significantly lower in the 3.0 mGy/h irradiated mice than in sham irradiated mice. The FST significantly decreased the catalase (CAT) activity and total glutathione (t-GSH) content in the brain and kidney, respectively. The superoxide dismutase (SOD) activity and t-GSH content in the liver of the 3.0 mGy/h irradiated mice were significantly lower than those of the non-FST-treated mice. The CAT activity in the lungs of mice exposed to 3.0 mGy/h γ-irradiation was higher than that of non-FST treated mice and mice treated with FST. However, no significant differences were observed in the levels of these antioxidant markers between the sham and irradiated groups except for the CAT activity in lungs. These findings suggest that the effects of low-dose-rate and low-dose γ-irradiation on FST are highly organ-dependent.

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  • Basic study on enhancement of antioxidant function by low- dose irradiation in mouse brain and its combined effect with ascorbic acid Reviewed

    Takahiro Kataoka, Yuto Yunoki, Norie Kanzaki, Kaori Sasaoka, Yusuke Kobashi, Tsuyoshi Ishida, Katsumi Hanamoto, Kiyonori Yamaoka

    Radioisotopes   69 ( 2 )   45 - 53   2020

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  • Health Effects of Low Dose Radiation: Health Promotion by Radon Hot Spring and Its Risk Invited Reviewed

    Kiyonori Yamaoka

    The Journal of Balneology, Climatology and Physical Medicine   83 ( 1 )   9 - 9   2020

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  • Study of biokinetics of radon progeny with thoron progeny as the isotope tracer Reviewed

    Akihiro Sakoda, Norie Kanzaki, Hiroshi Tanaka, Takahiro Kataoka, Kiyonori Yamaoka

    Japanese journal of health & research   40 ( 6 )   90 - 94   2019.6

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  • Reduction of radiation exposure in patients and cardiologists using a noise reduction technique in cardiac catheterization and percutaneous coronary intervention Reviewed

    Masayuki Kumashiro, Takahiro Kataoka, Shinobu Yokota, Shinobu Nakagawa, Fumiaki Kiyokawa, Hideki Mitsui, Shinji Osumi, Kiyonori Yamaoka

    Journal of JART   66 ( 2 )   45 - 57   2019.4

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  • Pressure dependence of X-rays produced by an LiTaO3 single crystal over a wide range of pressure Reviewed International journal

    Katsumi Hanamoto, Takahiro Kataoka, Kiyonori Yamaoka

    Applied Radiation and Isotopes   135   40 - 42   2018.5

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    The energy spectra of X-rays produced by an LiTaO3 single crystal have been measured at the pressures of 8 × 10−4−4 Pa. The energy spectra showed that the endpoint energy steadily increased with decrease of pressure at 2–4 Pa and gradually decreased with decrease of pressure at 0.1–2 Pa, and became almost constant below 0.1 Pa. The amount of X-rays steadily increased with decrease of pressure at 2–4 Pa and almost saturated below 0.5 Pa. The change of X-rays produced by the LiTaO3 single crystal was compared with the previous works and discussed in relation to the distance between the crystal surface and the target.

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  • Knowledge discovery of suppressive effect of disease and increased anti-oxidative function by low-dose radiation using self-organizing map Reviewed

    Norie Kanzaki, Takahiro Kataoka, Yusuke Kobashi, Yuto Yunoki, Tsuyoshi Ishida, Akihiro Sakoda, Yuu Ishimori, Kiyonori Yamaoka

    Radioisotopes   67 ( 2 )   43 - 57   2018.2

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    我々はこれまで、低線量放射線はマウス諸臓器中で抗酸化機能を亢進し、酸化ストレス関連疾患を抑制することを報告してきた。しかしながら、それらの結果は対象疾患も低線量放射線による処置の条件も様々で、有効性が立証された治療法は確立されていない。そこで、本研究では、それらの結果から低線量放射線の健康効果を明らかにすることを目的とし、ラドン療法のような低線量放射線を活用した治療法の新規適応症を探索した。データの解析には自己組織化マップ(SOM)を用い、不安定な抗酸化機能の変化を自己組織化マップの曖昧な表現で視覚的に直感的に捉えることにより、出力された疾患抑制効果と抗酸化機能亢進の関連性を検討した。その結果、ラドン療法の適応症である疼痛への効果には明らかな線量依存性があることがわかり、肝疾患や脳疾患においても、線量依存性はないもののその効果を期待できると予測できた。本研究は、ラドン療法のような低線量放射線を活用した治療法の応用に貢献できると考える。(著者抄録)

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  • Image Quality of the Coronary Angiography with Noise Reduction Technology to Decrease the Radiation Dose. Reviewed

    Masayuki Kumashiro, Takahiro Kataoka, Shinobu Yokota, Shinobu Nakagawa, Keisuke Otsuki, Nobuyuki Miyake, Shinji Osumi, Kiyonori Yamaoka

    Acta Medica Okayama   72 ( 2 )   153 - 164   2018

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    We examined the effects of a reduced exposure dose on the quality of images from an angiography device augmented with a noise reduction algorithm. Before its clinical application, we compared the diameter of the discrimination limit of the hole with that in the conventional method by a visual evaluation with a contrast-detail (C-D) phantom imaged using the target dose. Based on the results, a reducible dose was determined and applied clinically. The sample population consisted of patients being followed up after percutaneous coronary intervention (PCI) for coronary artery disease; we evaluated the effects of the exposure reduction on image quality. A significant dose reduction was observed by the noise-reduction method compared to the conventional method; the radiation dose to the flat panel detector (FPD) could be reduced to 70 nGy per frame. Clinically, a dose reduction of approx. 40% was obtained while maintaining image quality almost equal to that of the conventional method.

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  • Reduction of radiation exposure in patients and cardiologists using a noise reduction technique in cardiac catheterization and percutaneous coronary intervention Reviewed

    熊代正行, 熊代正行, 片岡隆浩, 横田忍, 中川忍, 清川文秋, 光井英樹, 大角真司, 山岡聖典

    日本診療放射線技師会誌   65 ( 5 )   31 - 40   2018

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  • ラドン吸入による抗酸化機能の亢進と抗酸化ビタミン摂取との複合効果に関する研究動向 Reviewed

    片岡隆浩,山岡聖典

    放射線生物研究   53 ( 3 )   211 - 222   2018

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  • Measurements of radon activity concentration in mouse tissues and organs Reviewed International journal

    Yuu Ishimori, Hiroshi Tanaka, Akihiro Sakoda, Takahiro Kataoka, Kiyonori Yamaoka, Fumihiro Mitsunobu

    Radiation and Environmental Biophysics   56 ( 2 )   161 - 165   2017.5

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    The purpose of this study is to investigate the biokinetics of inhaled radon, radon activity concentrations in mouse tissues and organs were determined after mice had been exposed to about 1 MBq/m(3) of radon in air. Radon activity concentrations in mouse blood and in other tissues and organs were measured with a liquid scintillation counter and with a well-type HP Ge detector, respectively. Radon activity concentration in mouse blood was 0.410 +/- 0.016 Bq/g when saturated with 1 MBq/m(3) of radon activity concentration in air. In addition, average partition coefficients obtained were 0.74 +/- 0.19 for liver, 0.46 +/- 0.13 for muscle, 9.09 +/- 0.49 for adipose tissue, and 0.22 +/- 0.04 for other organs. With these results, a value of 0.414 for the blood-to-air partition coefficient was calculated by means of our physiologically based pharmacokinetic model. The time variation of radon activity concentration in mouse blood during exposure to radon was also calculated. All results are compared in detail with those found in the literature.

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  • 強制水泳誘導うつ病マウスに対するラドン吸入による抗うつ効果の検討(Study on Antidepressant-Like Effects of Radon Inhalation on Forced Swim Induced Depression in Mice) Reviewed

    大和 恵子, 片岡 隆浩, 西山 祐一, 高田 裕司, 恵谷 玲央, 山岡 聖典

    Radioisotopes   65 ( 12 )   493 - 506   2016.12

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    雄8〜9週齢ICRマウスを用いて強制水泳試験(FST)を行い、試験により誘導されるうつ病様症状に対するラドン吸入の効果について検証した。マウスの運動機能や不安状態に関してはオープンフィールド試験(OFT)により評価を行い、次に、FST誘導うつ病様症状に対するラドン前処理の効果(予防効果)およびラドン後処理の効果(治療効果)を調べると共に、生化学的検査により、脳内および血中モノアミン類、抗酸化物質の変化を調べた。その結果、予防効果の面では、FST前の2000Bq/m3の24hラドン吸入により、絶望行動が低下し、水泳意欲の向上が観察された。また、治療効果においては、2000Bq/m3の24hラドン吸入により、水泳意欲の向上とうつ病様症状への効果が認められ、水泳ストレスにより、脳内ノルエピネフリンとドーパミンが低下すると共に、FST誘導うつ病状態は血漿中スーパーオキシドジスムターゼ(SOD)活性低下および脳内脂質過酸化物(LPO)含量を増加させることが示された。さらに、ラドン吸入は脳組織内のモノアミン類(セロトニン、ノルエピネフリン、ドーパミン)を増加させると共に、FST前処理においてSOD活性を上昇させ、FST後処理におけるLPO含量を低下させた。以上の結果から、ラドン吸入は、マウス水泳ストレスにより誘導されるうつ病様症状を予防し、抑制することが明らかにされた。

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  • Pressure dependence of X-rays produced by an LiTaO3 single crystal at the pressures of 1-20 Pa Reviewed International journal

    Katsumi Hanamoto, Takahiro Kataoka, Kiyonori Yamaoka

    Applied Radiation and Isotopes   116   134 - 137   2016.10

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    The energy spectra of X-rays produced by an LiTaO3 single crystal have been measured at pressures of 1-20 Pa. The energy spectra showed that the endpoint energy and the amount of X-rays gradually increased with the decrease of pressure at 5-8 Pa and abruptly increased around 4 Pa and below. A maximum endpoint energy of 70 keV was obtained using the LiTaO3 single crystal with 5 mm thickness at a pressure of 3 Pa. The change of X-rays produced by the LiTaO(3)single crystal was discussed in relation to the breakdown potential at the pressures. (C) 2016 Elsevier Ltd. All rights reserved.

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  • 三朝ラドン効果研究の意義と近年の研究動向 Reviewed

    片岡隆浩, 神崎訓枝, 笹岡香織, 小橋佑介, 迫田晃弘, 田中裕史, 石森有, 光延文裕, 山岡聖典

    放射線生物研究   51 ( 3 )   296 - 297   2016.9

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  • Possible applications of radon therapy in veterinary care for oxidative stress-induced kidney damage Reviewed

    Kaori Sasaoka, Takahiro Kataoka, Norie Kanzaki, Kiyonori Yamaoka

    Free Radicals and Health   61 - 74   2016.1

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    Oxidative stress in the body is considered an imbalance between the production and removal of reactive oxygen species (ROS). Ischemic acute renal failure, chronic renal failure, uremia, glomerulonephritis, and diabetic nephropathy are ROS-related diseases. In the veterinary field, a few studies of chronic kidney failure related to oxidative stress have been reported. Radon therapy has been used in Japan and Europe, and has been shown to have beneficial effects on ROS-related diseases such as bronchial asthma, arteriosclerosis, osteoarthritis, and pain-related diseases. We have demonstrated that radon inhalation increases antioxidative functions in kidney, and inhibits oxidative stress-induced kidney damage in animals. In addition, radon exposure systems for pets have already been developed. Therefore, we review the possible applications of radon therapy in veterinary care for oxidative stress-induced kidney damage.

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  • 三朝ラドン温泉の健康効果に関する最近の研究動向 Invited Reviewed

    片岡隆浩, 迫田晃弘, 恵谷玲央, 石森 有, 光延文裕, 山岡聖典

    温泉科学(日本温泉科学会学会誌)   64 ( 4 )   380 - 387   2015.3

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  • The possible applications of radon inhalation treatment as antioxidant therapy for hepatopathy

    Takahiro Kataoka, Akihiro Sakoda, Reo Etani, Yuu Ishimori, Fumihiro Mitsunobu, Kiyonori Yamaoka

    Radon: Geology, Environmental Impact and Toxicity Concerns   133 - 148   2015.1

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    The possibility of antioxidant therapy has been reported for several diseases such as ischemic stroke. The therapy could also be applied for diseases caused by reactive oxygen species (ROS). It has been reported that ROS or free radicals may cause various types of hepatopathy, including alcoholic liver disease. Low dose (0.5 Gy) X- or γ- irradiation activates the antioxidative functions of the mouse liver and inhibits ROS- or free radical-induced hepatopathy. Radon therapy is performed mainly for pain-related diseases in Japan and Europe. Several clinical studies have been reported, but the possible mechanisms of the beneficial effects remain unknown. Recently, we have reported that the possible mechanism of radon therapy is the activation of antioxidative functions following radon inhalation. For example, radon inhalation inhibits and alleviates chronic constriction injury induced pain or inflammatory pain in mice due to the activation of antioxidative functions. In addition, although hepatopathy is not the main indication for radon therapy, our recent studies suggested that radon inhalation inhibits hepatopathy caused by ROS or free radicals. In this chapter, based on experiments with mice, we reviewed the possible applications of radon inhalation as an antioxidant therapy for hepatopathy from the viewpoints of recent antioxidant therapy, hepatopathy induced by ROS or free radicals, and the beneficial effects of radon inhalation for hepatopathy.

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  • ラジウム・ラドン温泉の健康効果-ラドン療法の効果と機構に関する最近の研究動向-

    山岡聖典

    健康と温泉フォーラム   22 - 29   2014.10

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  • Study on health effects of exposure to radon recent studies on effects and mechanisms of radon therapy Reviewed

    12 ( 4 )   267 - 276   2013.12

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  • ラドン温泉はがんの予防や治療に有効か? Invited Reviewed

    山岡聖典

    日本がん予防学会 NEWS LETTER   77   3 - 3   2013.9

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  • Absorbed doses of lungs from radon retained in airway lumens of mice and rats Reviewed International journal

    Akihiro Sakoda, Yuu Ishimori, Kiyonori Yamaoka, Takahiro Kataoka, Fumihiro Mitsunobu

    Radiation and Environmental Biophysics   52 ( 3 )   389 - 395   2013.8

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    This paper provides absorbed doses arising from radon gas in air retained in lung airway lumens. Because radon gas exposure experiments often use small animals, the calculation was performed for mice and rats. For reference, the corresponding computations were also done for humans. Assuming that radon concentration in airway lumens is the same as that in the environment, its progeny's production in and clearance from airways were simulated. Absorbed dose rates were obtained for three lung regions and the whole lung, considering that secretory and basal cells are sensitive to radiation. The results showed that absorbed dose rates for all lung regions and whole lung generally increase from mice to rats to humans. For example, the dose rates for the whole lung were 25.4 in mice, 41.7 in rats, and 59.9 pGy (Bq m(-3))(-1) h(-1) in humans. Furthermore, these values were also compared with lung dose rates from two other types of exposures, that is, due to inhalation of radon or its progeny, which were already reported. It was confirmed that the direct inhalation of radon progeny in the natural environment, which is known as a cause of lung cancer, results in the highest dose rates for all species. Based on the present calculations, absorbed dose rates of the whole lung from radon gas were lower by a factor of about 550 (mice), 200 (rats), or 70 (humans) than those from radon progeny inhalation. The calculated dose rate values are comparatively small. Nevertheless, the present study is considered to contribute to our understanding of doses from inhalation of radon and its progeny.

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  • ラドン療法に関する最近の研究動向- 鎮痛効果に着目して- Reviewed

    大和恵子, 片岡隆浩, 西山祐一, 山岡聖典

    放射線生物研究   48 ( 1 )   66 - 81   2013.3

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  • Lung dosimetry of inhaled radon progeny in mice Reviewed International journal

    Akihiro Sakoda, Yuu Ishimori, Kosuke Fukao, Kiyonori Yamaoka, Takahiro Kataoka, Fumihiro Mitsunobu

    Radiation and Environmental Biophysics   51 ( 4 )   425 - 442   2012.11

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    Biological response of exposure to radon progeny has long been investigated, but there are only few studies in which absorbed doses in lungs of laboratory animals were estimated. The present study is the first attempt to calculate the doses of inhaled radon progeny for mice. For reference, the doses for rats and humans were also computed with the corresponding models. Lung deposition of particles, their clearance, and energy deposition of alpha particles to sensitive tissues were systematically simulated. Absorbed doses to trachea and bronchi, bronchioles and terminal bronchioles, alveolar-interstitial regions, and whole lung were first provided as a function of monodisperse radon progeny particles with an equilibrium equivalent radon concentration of 1 Bq m(-3) (equilibrium factor, 0.4 and unattached fraction, 0.01). Based on the results, absorbed doses were then calculated for (1) a reference mine condition and (2) a condition previously used for animal experiments. It was found that the whole lung doses for mice, rats, and humans were 34.8, 20.7, and 10.7 nGy (Bq m(-3))(-1) h(-1) for the mine condition, respectively, while they were 16.9, 9.9, and 6.5 nGy (Bq m(-3))(-1) h(-1) for the animal experimental condition. In both cases, the values for mice are about 2 times higher than those for rats, and about 3 times higher than those for humans. Comparison of our data on rats and humans with those published in the literature shows an acceptable agreement, suggesting the validity of the present modeling for mice. In the future, a more sophisticated dosimetric study of inhaled radon progeny in mice would be desirable to demonstrate how anatomical, physiological, and environmental parameters can influence absorbed doses.

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  • Pressure dependence of X-rays produced by an LiTaO3 single crystal at low pressures Reviewed

    Katsumi Hanamoto, Atsushi Kawabe, Akihiro Sakoda, Takahiro Kataoka, Mari Okada, Kiyonori Yamaoka

    Nuclear Instruments and Methods in Physics Research A   669   66 - 69   2012.3

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    The energy spectra of X-rays produced by an LiTaO3 single crystal have been measured at pressures of 5-50 Pa. The energy spectra showed that the amount of X-rays increased exponentially and the endpoint energy of the spectra increased linearly with the decrease of pressure at pressures of 10-25 Pa. A maximum endpoint energy of about 22 key was obtained using an LiTaO3 single crystal with 0.5 mm thickness at the pressure of 10 Pa. The maximum energy produced by the present experimental setup was estimated assuming that the LiTaO3 single crystal forms a parallel-plate capacitor. The estimated energy reasonably agreed with the energy obtained. The pressure dependence of the endpoint energy was discussed in relation to the breakdown potential at low pressures. (C) 2011 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.nima.2011.12.028

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  • Activation of bio-defense system by radon inhalation and its applicable possibility for treatment of lifestyle diseases

    Takahiro Kataoka, Akihiro Sakoda, Yuu Ishimori, Fumihiro Mitsunobu, Kiyonori Yamaoka

    Handbook of Radon: Properties, Applications and Health   335 - 356   2012.1

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    Adequate oxygen stress induced by radon inhalation activates chemical biological protective functions, such as induction of the synthesis of superoxide dismutase and glutathione peroxidase. We studied the probability that activation of this function alleviated various oxidation injuries. The results showed that 1) Radon inhalation enhanced the antioxidative function and membrane fluidity in some mouse organs, and biogenic amine neurotransmitters in the rabbit brain; 2) To elucidate a more effective condition for radon inhalation, mice inhaled radon before carbon tetrachloride (CCl4) administration. The results show that radon inhalation alleviates CCl4-induced hepatopathy; 3) Radon inhalation elevated antioxidant enzymes in patients with bronchial asthma and osteoarthritis; 4) Radon inhalation alleviated the symptoms of hypertension, diabetes and pain in humans; 5) Radon inhalation elevated the p53 protein level and SOD activity in the blood of residents of the Misasa radon hot spring district. Moreover, we compared biochemically the radon effects and thermal effects on humans in radon hot spring therapy, the effects of thoron and thermal treatment for aging-related diseases in humans, and the effects of radon inhalation on acute alcohol-induced oxidative injury of the liver and brain in mice. These findings suggest that radon inhalation alleviates various reactive oxygen species-related injuries. It is highly possible that adequate activation of the functions of the living body by radon inhalation can contribute to preventing or reducing reactive oxygen species-related injuries (lifestyle diseases) which are thought to involve peroxidation. © 2012 by Nova Science Publishers, Inc. All rights reserved.

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  • Inhibitory Effects of Pre and Post Radon Inhalation on Carbon Tetrachloride-induced Oxidative Damage in Mouse Organs Reviewed

    Y.Nishiyama, T.Kataoka, J.Teraoka, A.Saokda, Y.Ishimori, K.Yamaoka

    Radioisotopes   61 ( 5 )   231 - 241   2012

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    DOI: 10.3769/radioisotopes.61.231

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  • Activation of biodefense system by low-dose irradiation or radon inhalation and its applicable possibility for treatment of diabetes and hepatopathy. Reviewed International journal

    Takahiro Kataoka, Kiyonori Yamaoka

    ISRN Endocrinology, Volume 2012 (2012), Article ID 292041, 11 pages   2012

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    Adequate oxygen stress induced by low-dose irradiation activates biodefense system, such as induction of the synthesis of superoxide dismutase (SOD) and glutathione peroxidase. We studied the possibility for alleviation of oxidative damage, such as diabetes and nonalcoholic liver disease. Results show that low-dose γ-irradiation increases SOD activity and protects against alloxan diabetes. Prior or post-low-dose X- or γ-irradiation increases antioxidative functions in livers and inhibits ferric nitrilotriacetate and carbon tetrachloride-induced (CCl(4)) hepatopathy. Moreover, radon inhalation also inhibits CCl(4)-induced hepatopathy. It is highly possible that low-dose irradiation including radon inhalation activates the biodefence systems and, therefore, contributes to preventing or reducing reactive oxygen species-related diabetes and nonalcoholic liver disease, which are thought to involve peroxidation.

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  • Basic Study on Positive Effects of Radon Inhalation on Pet's Health Reviewed

    Takahiro KATAOKA, Rikizo TOKUNAGA, Akihiro SAKODA, Atsushi KAWABE, Katsumi HANAMOTO, Kiyonori YAMAOKA

    RADIOISOTOPES   61 ( 1 )   1 - 8   2012

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    DOI: 10.3769/radioisotopes.61.1

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  • A comparative study on effect of continuous radon inhalation on several-time acute alcohol-induced oxidative damages of liver and brain in mouse Reviewed

    Takahiro Kataoka, Akihiro Sakoda, Masaaki Yoshimoto, Teruaki Toyota, Yuki Yamamoto, Yuu Ishimori, Katsumi Hanamoto, Atsushi Kawabe, Fumihiro Mitsunobu, Kiyonori Yamaoka

    Radiation Safety Management   10 ( 1 )   1 - 7   2011.12

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    DOI: 10.12950/rsm.10.1

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  • Performance of the First Japanese Large-Scale Facility for Exposing Small Animals to Radon Reviewed International journal

    Yuu Ishimori, Fumihiro Mitsunobu, Kiyonori Yamaoka, Hiroshi Tanaka, Takahiro Kataoka, Akihiro Sakoda

    Radiation Protection Dosimetry   146 ( 1-3 )   31 - 33   2011.7

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    A radon test facility for small animals was developed in order to increase the statistical validity of differences of the biological response in various radon environments. This paper illustrates the performances of that facility, the first large-scale facility of its kind in Japan. The facility has a capability to conduct approximately 150 mouse-scale tests at the same time. The apparatus for exposing small animals to radon has six animal chamber groups with five independent cages each. Different radon concentrations in each animal chamber group are available. Because the first target of this study is to examine the in vivo behaviour of radon and its effects, the major functions to control radon and to eliminate thoron were examined experimentally. Additionally, radon progeny concentrations and their particle size distributions in the cages were also examined experimentally to be considered in future projects.

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  • Study of fundamental physical properties of mineral grains toward understanding radon emanation phenomenon Reviewed

    Akihiro Sakoda, Katsumi Hanamoto, Yuu Ishimori, Atsushi Kawabe, Takahiro Kataoka, Yuki Yamamoto, Yuichi Nishiyama, Kiyonori Yamaoka

    Radiation Protection Dosimetry   146 ( 1-3 )   2011.7

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  • Radiation exposure to the hands of physicians during CT fluoroscopy-guided interventions Reviewed

    Atsushi Kawabe, Akihiro Sakoda, Takahiro Kataoka, Hideo Gobara, Takao Hiraki, Kentaro Shibamoto, Hitoshi Sato, Katsumi Hanamoto, Hidefumi MimurA, Susumu Kanazawa, Kiyonori Yamaoka

    Radiation Protection Dosimetry   146 ( 1-3 )   2011.7

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  • An Assessment of Radioactivity Levels of Pb-210 and K-40 in Tobacco and Radiation Exposure from Smoking Reviewed

    Tomohiro Nagamatsu, Akihiro Sakoda, Takahiro Kataoka, Toshiro Ono, Kiyonori Yamaoka

    Acta Medica Okayama   65 ( 2 )   91 - 95   2011.4

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    No research has been conducted on the radiation influence of tobacco on the alimentary system, although there have been some previous works on the respiratory system. In this study, the radioactive concentrations of Pb-210 and K-40 in a cigarette sample were first measured. The transfer factors of the nuclides from tobacco into smoke and solution (saliva and/or alcohol) were then examined. Moreover, the radiation doses from smoke inhalation were also evaluated. The radioactive concentrations of Pb-210 and K-40 in the cigarette tobacco were 0.01 and 0.3 Bq/cigarette. Since this Pb-210 activity and the Po-210 activity previously reported for the same sample were comparable, it can be concluded that there was a radioactive equilibrium between the 2 nuclides. The observed transfer factor of Pb-210 (12%) into smoke was almost the same as that of K-40 (15%), whereas the reported value for Po-210 (60%) was significantly higher. The radiation doses due to inhalation of cigarette smoke varied from organ to organ, depending on the organotropic properties of the nuclide. For example, the kidneys, respiratory tract, and spleen showed relatively high doses from Pb-210 and Po-210. The leaching rates indicated an inconsistent tendency related to solution types. This result could suggest that alcohol drinking, which is common in smokers, does not especially enhance the leaching characteristics.

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  • Possibility for Inhibition of Aging and Lifestyle Diseases by Low-dose Irradiation Invited Reviewed

    7 ( 5 )   48 - 54   2011

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  • AIR GAP代用法によるIVR患者被ばく低減のモンテカルロ検証 Reviewed

    川辺 睦, 佐藤 斉, 迫田晃弘, 片岡隆浩, 花元克巳, 深井喜代子, 三村秀文, 山岡聖典

    医学物理   30 ( 2 )   351 - 352   2010.4

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  • Primary Functions of the First Japanese Large-Scale Facility for Exposing Small Animals to Radon Reviewed

    Y.Ishimori, F.Mitsunobu, K.Yamaoka, Hiroshi Tanaka, T.Kataoka, A.Sakoda

    Japanese Journal of Health Physics   45 ( 1 )   65 - 71   2010.3

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    DOI: 10.5453/jhps.45.65

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  • Estimation of Occupational Radiation Exposure in Veterinary Practice Reviewed

    川辺睦, 山田一孝, 花元克巳, 迫田晃弘, 片岡隆浩, 山岡聖典

    動物臨床医学   19 ( 4 )   113 - 117   2010

  • An Assessment of Radioactivity Level in 51Cr-contaminated Dry Solid Waste Generated from a Research Facility for Verification of Clearance Levels Reviewed

    Nagamatsu Tomohiro, Hanafusa Tadashi, Ono Toshiro, Yamaoka Kiyonori

    Radiation Safety Management   9 ( 1 )   7 - 12   2010

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    Radioactive waste generated from research laboratories and other facilities is regulated by the Law Concerning Prevention from Radiation Hazards due to Radioisotopes etc. (Prevention Law). However, the Prevention Law does not provide the level of clearance or the procedures to follow for compliance monitoring. To assess radioactivity amounts for making decisions about clearance levels, the radioactivity levels in dry solid semi-combustible wastes generated from biomedical research, such as 51Cr-release assays, were measured and evaluated. Radioactivity of semi-combustible waste was 1.42-6.32% of the initial level. In comparison, records for the past 8 years in the Shikata Laboratory, Department of Radiation Research, Okayama University Advanced Science Research Center, indicated 7% to 90% of the initial radioactivity remained in the waste and was differed widely among researchers. This study determined an accurate radioactivity level in dry solid waste, which could lead to savings in disposal costs.<br>

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  • 放射線影響を考える-動物実験から見えてきたこと-:低線量放射線による抗酸化機能の亢進と酸化障害の緩和の可能性 Invited Reviewed

    山岡聖典

    アニテックス   21 ( 3 )   8 - 13   2009.5

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  • 低線量放射線の健康への影響と医療への応用 Invited Reviewed

    山岡聖典

    日本臨床矯正歯科医会雑誌   21 ( 1 )   14 - 19   2009

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  • 低線量放射線の世界-その効用研究の現段階-:低線量放射線の健康への影響と医療への応用に関する研究 Invited Reviewed

    山岡聖典

    原子力eye   54 ( 9 )   5 - 9   2008.9

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  • Methodological Approach for Assessment of the Radioactivity Level in Dry Solid Waste Reviewed

    Tomohiro Nagamatsu, Akihiro Sakoda, Katsumi Hanamoto, Ikuo Kinno, Tadashi Hanafusa, Kiyonori Yamaoka, Toshiro Ono

    Radiation Safety Management   7 ( 1 )   6 - 10   2008

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    DOI: 10.12950/rsm2002.7.6

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  • Basic Study on Activation of Antioxidation Function in Some Organs of Mice by Radon Inhalation Using New Radon Exposure Device Reviewed

    Shinya NAKAGAWA, Takahiro KATAOKA, Akihiro SAKODA, Yuu ISHIMORI, Katsumi HANAMOTO, Kiyonori YAMAOKA

    RADIOISOTOPES   57 ( 4 )   241 - 251   2008

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  • Discrimination between depleted uranium and natural uranium in uranium compounds stored in Okayama University Reviewed

    Environmental research & control   30 ( 1 )   33 - 37   2008

  • 放射線ホルミシス研究の現状と今後 Invited Reviewed

    山岡聖典

    電気評論   503 ( 91 )   51 - 55   2006

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  • Study on Radioactivity and Negative Ion Originated from a Thoron Artificial Hot Spring Reviewed

    Akihiro SAKODA, Takahiro KATAOKA, Katsumi HANAMOTO, Kiyonori YAMAOKA

    RADIOISOTOPES   54 ( 9 )   375 - 383   2005

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    DOI: 10.3769/radioisotopes.54.375

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  • 埋蔵文化財発掘調査及び建設工事が環境放射線へ及ぼす影響評価 Reviewed

    永松知洋, 花元克巳, 小野俊朗, 山岡聖典

    環境制御   27   11 - 16   2005

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  • 低線量放射線による抗酸化機能の亢進と酸化傷害の緩和に関する研究 Invited Reviewed

    山岡聖典

    過酸化脂質研究(過酸化脂質フリーラジカル学会誌)   29 ( 1 )   23 - 26   2005

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  • 三朝温泉におけるラドン療法とその機構解明の現状 Invited Reviewed

    山岡聖典

    日本保健物理学会 水中ラドンに関する専門研究会活動報告書   103 - 106   2004.8

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  • 低線量放射線の生体への影響 Invited Reviewed

    山岡聖典

    Radiology Frontier   7 ( 4 )   13 - 17   2004.4

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  • Spa therapy for patients with respiratory disease. Clinical efficacy and action mechanisms of the therapy on asthma Reviewed

    光延文裕, 保崎泰弘, 芦田耕三, 浜田全紀, 山岡聖典, 谷崎勝朗

    岡大三朝医療センター研究報告   75   61 - 63   2004

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  • 生理活動指標を用いたマイナスイオンの身体への作用の検討(Using Physiological Indices to Consider the Effects of Negative Air Ions on the Human Body) Reviewed

    白井 喜代子, 山岡 聖典, 花元 克巳, 山本 尚武

    Journal of International Society of Life Information Science   22 ( 1 )   97 - 102   2004

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    被験者への吸入濃度を7000個/cm3あるいは20000個/cm3に調整したマイナスイオンによる自律神経系と循環器系への作用について,それぞれ皮膚電気活動と皮膚血流量を指標に測定した.その結果,皮膚血流量には有意な変化は見られなかったが,皮膚電気活動には有意な変化が認められた.これらより,マイナスイオンが少なくとも自律神経系などの生理活動に作用していることが示唆された

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  • Histidine-rich glycoprotein plus zinc reverses growth inhibition of vascular smooth muscle cells by heparin Reviewed International journal

    S Mori, R Shinohata, M Renbutsu, HK Takahashi, YI Fang, K Yamaoka, M Okamoto, Yamamoto, I, M Nishibori

    Cell and Tissue Research   312 ( 3 )   353 - 359   2003.6

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    Vascular smooth muscle cell (SMC) hyperplasia is known to be an important component in the pathogenesis of arteriosclerosis and restenosis. Although heparin has been well recognized as the representative molecule suppressing SMC growth in vitro, attempts to use heparin as a therapeutic anti-restenosis drug have not favorably influenced the angiographic or clinical outcome after angioplasty in some clinical trials. In this study, we have examined the effect of histidine-rich glycoprotein (HRG), a relatively abundant serum glycoprotein (similar to100 mug/ml in human serum), on the growth inhibition of cultured vascular SMC by heparin. Vascular SMC growth was significantly inhibited by heparin, giving nearly 85% inhibition with 100 mug/ml heparin. HRG reversed heparin-induced SMC growth inhibition in a dose dependent manner; 75% restoration of cell growth was observed when 100 mug/ml of HRG was co-added with 100 mug/ml heparin. Interestingly, micromolar concentrations of the zinc ion (0-10 muM), compatible with concentrations released from activated platelets, were found to enhance the restorative action of HRG. Western blot experiment demonstrated no significant amounts of the HRG moiety in fetal bovine serum, eliminating the possible contribution of contaminant HRG from culture media. These findings indicate that HRG, in combination with the zinc ion, plays a role in modulating the SMC growth response in pathophysiological states and explain the lack of success of heparin as a therapeutic anti-restenosis drug in clinical trials.

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  • Elevation of antioxidant enzymes in the clinical effects of radon and thermal therapy for bronchial asthma Reviewed International journal

    F Mitsunobu, K Yamaoka, K Hanamoto, S Kojima, Y Hosaki, K Ashida, K Sugita, Y Tanizaki

    Journal of Radiation Research   44 ( 2 )   95 - 99   2003.6

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    An increased systemic production of oxygen-free radicals by activated inflammatory cells is thought to be involved in the pathophysiology of asthma. The aim of this study is to evaluate the clinical effects of radon and thermal therapy on asthma in relation to antioxidant enzymes and lipid peroxide. Radon and thermal therapy were performed once a week. All subjects went to a hot bathroom with a high concentration of radon, and nasal inhalation of vapor from a hot spring was performed for 40 min once a day under conditions of high humidity. The room temperature was 48degreesC; the room radon concentration was 2,080 Bq/m(3). Blood samples were collected at 2 h, 14, and 28 days after the first therapy. A blood sample also was collected before the first therapy (at body temperature and background radon level) to be used as the control. The forced expiratory volume in one second (%FEV1) was significantly increased 28 days after the first therapy. Oil day 28, the catalase (CAT) activity was significantly increased in comparison with the control. The superoxide dismutase (SOD) activity was significantly increased compared to the control after first inhalation. On days 14 and 28, the lipid peroxide level was significantly decreased in comparison with the control. In conclusion, the present pilot study has shown that radon and thermal therapy improved the pulmonary function of asthmatics by increasing the reduced activities of antioxidant enzymes.

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  • 低線量放射線が低カタラーゼマウスにおけるカタラーゼを含む抗酸化物質に及ぼす効果の検証 Reviewed

    野村崇治, 山岡聖典, 森秀治, 汪達紘, 吉良尚平, 酒井一夫

    電力中央研究所研究報告   G03001   2003.5

  • High affinity binding of serum histidine-rich glycoprotein to nickel-nitrilotriacetic acid: The application to microquantification Reviewed International journal

    S Mori, HK Takahashi, K Yamaoka, M Okamoto, M Nishibori

    Life Sciences   73 ( 1 )   93 - 102   2003.5

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    Histidine-rich glycoprotein (HRG) is a serum protein with possible pluripotent activities. In this study, a method for the quantification of rabbit histidine-rich glycoprotein (rHRG) was developed based upon the high affinity binding profile of rHRG to nickel-nitrilotriacetic acid (Ni-NTA), an improved chelation agent. When the binding profile of Ni-NTA for whole serum proteins was assessed by Western blotting, Ni-NTA exhibited the binding specificity only to rHRG even after washing with 20 mM imidazole, owing to the unusual amounts of histidine residues in rHRG. In the following experiments, the rHRG immobilized onto a microplate with specific antibody was determined spectrophotometrically with peroxidase-labeled Ni-NTA. This method permitted evaluation of rHRG concentrations ranging from 1.0 to 100 ng/ml, and was actually applicable to the monitoring of rHRG in Resource Q-fractionated serum preparations. Also, the co-addition of L-histidine into the incubation mixture significantly diminished the specific binding between rHRG and Ni-NTA. These findings indicate the potential usefulness of this method for the specific measurement of small amounts of rHRG and for understanding the roles of abundant histidine residues in rHRG-metal cation interaction. (C) 2002 Elsevier Science Inc. All rights reserved.

    DOI: 10.1016/S0024-3205(03)00261-3

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  • MR imaging of vertebral metastases at 0.2 Tesla: Clinical evaluation of T1-weighted opposed-phase gradient-echo imaging Reviewed International journal

    Seiichiro Ohno, Izumi Togami, Tetsuro Sei, Kentaro Ida, Masatoshi Tsunoda, Kiyonori Yamaoka, Susumu Kanazawa, Yoshio Hiraki

    Physiological Chemistry and Physics and Medical NMR   35 ( 2 )   145 - 156   2003

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    The purpose of this study was to evaluate clinically T1-weighted spin-echo imaging (T1-SE) and T1-weighted opposed-phase gradient-echo (T1-opposed GRE) in medical examinations for vertebral metastases using 0.2 Tesla MRI. Twenty-one patients (9 males and 12 females, 105 vertebrae) with non-neoplastic lesions were assigned to the normal group (Group N), whereas 27 patients (16 males and 11 females, 133 vertebrae) with malignant metastatic vertebral lesions were assigned to the metastatic group (Group M). Using quantitative analysis, the contrast to noise ratio (CNR) for bone marrow to muscle in the region of interest (ROI) defined by the operator were determined with both groups, whereas the CNR for lesion to bone marrow was determined with Group M. In the subjective analysis, 275 vertebrae of 27 patients in Group M were evaluated. There were significant differences in the Group M between CNR values, T1-SE and T1-opposed GRE. The evaluation by T1-SE image alone was rated as 85.0% for sensitivity, 99.3% for specificity, respectively. On the other hand, evaluation rate only by T1-opposed GRE was 98.5% for sensitivity, 82.4% for specificity, respectively. T1-opposed GRE image is an effective tool for 0.2 Tesla MRI to examine metastatic bone marrow tumors. These findings indicate the necessity of both T1-SE and T1-opposed GRE in diagnostic imaging of vertebral metastases using 0.2 Tesla MRI.

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  • 化学発がんの非遺伝毒性的メカニズムの解明に関する最近の動向 Reviewed

    山岡聖典, 花元克巳, 稲 恭宏, 片岡隆浩, 佐野正展, 川辺 睦, 氏福亜矢子

    岡山大学医学部保健学科紀要   14 ( 1 )   1 - 14   2003

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  • Elevation of antioxidants in the kidneys of mice by low-dose irradiation and its effect on Fe3+–NTA-induced kidney damage Reviewed

    T. Nomura, K. Yamaoka, K. Sakai

    Radiation and Homeostasis   1236   481 - 485   2002.7

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    We previously examined the effects of 0.5 Gy of γ- or X-irradiation on endogenous antioxidative materials, including glutathione, glutathione-related enzymes, superoxide dismutase and catalase in the liver, pancreas and brain of mice. An increase in the antioxidants was observed soon after the irradiation. We also demonstrated that the low-dose irradiation gave suppressive effects on reactive oxygen species (ROS)-related disease models such as acute hepatitis, type I diabetes and Parkinson's disease. These results suggested that the suppression or inhibition of the ROS-related diseases were made through the elevation of the antioxidants. We studied the effects of irradiation (0.5 Gy of γ-ray) reducing the renal oxidative damage in Fe3+ nitrilotri-acetate (NTA) injected mice. We examined transaminase activity, lipid peroxide level and those levels of antioxidants in the mouse. Both transaminase activities and lipid peroxide level accelerated decrease to normal level by the irradiation. The levels of total glutathione content and the activities of its related enzymes were slightly increased in the irradiated group. On the other hand, catalase (CAT) activity was significantly increased by the irradiation. These findings suggested that low-dose irradiation relieved functional disorder in the kidney of mice with ROS-related diseases, probably through enhancing antioxidant, in particular CAT activity. © 2002 Elsevier Science B.V.

    DOI: 10.1016/S0531-5131(02)00151-6

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  • 慢性期および急性期病棟におけるアメニテイに関する比較研究 Reviewed

    小野清美, 林優子, 山岡聖典

    日本インテリア学会論文報告集   12   43 - 47   2002.3

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  • Simple and Easy Method for Measurement of Airborne Radioactive Iodine(125I). Reviewed

    渋谷光一, 山岡聖典, 永松知洋, 花元克巳, 川崎祥二, 平木祥夫

    Radioisotopes   51 ( 2 )   16 - 20   2002

  • 低線量放射線の適応応答に関する最近の研究動向とその意義 Reviewed

    楠原俊昌, 花元克己, 山岡聖典

    岡山大学医学部保健学科紀要   13 ( 1 )   7 - 15   2002

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  • 看護の視点からのアメニティ創出への試み ラッピング技法を用いてのアプローチから Reviewed

    小野清美, 林優子, 大井伸子, 奥田博之, 山岡聖典

    岡山大学医学部保健学科紀要   12 ( 1 )   27 - 36   2001.12

  • 放射性ヨウ素の空気中濃度測定法の簡便化に向けての基礎的検討 Reviewed

    渋谷光一, 山岡聖典, 永松知洋, 川崎祥二, 平木祥夫

    岡山大学保健学科紀要   11 ( 1 )   35 - 39   2001

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    空気中の放射性ヨウ素(125I)の濃度を簡便に測定する為に,活性炭濾紙を装着したホルダを50mlの注射器にセットした簡易な装置を考案・試作した.Nal(T1)ウェルタイプシンチレーションカウンタによって調べた活性炭濾紙での125Iの捕集効率は,44.5%であった.50ml注射器で1lの空気を活性炭濾紙に通し,その放射能とバックグランドをそれぞれ30分間,Nal(T1)ウェルタイプシンチレーションカウンタで測定した場合,空気中濃度限度の2.12倍の濃度であれば測定可能と考えられた.又,活性炭濾紙とプラスチックホルダからの気体状ヨウ素の漏れを防いで捕集効率を94.3%以上に上げることができれば,空気中濃度限度の125Iを測定できると考えられた.したがって,放射性ヨウ素の取り扱い中に,簡便に安価に空気中濃度の異常を検出する方法として有効と考えられた

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  • 鉄による培養細胞の生育変化とこれに対する低線量放射線の作用(Effects of Low-dose Irradiation on the Growth Changes in Culture Cells by Iron) Reviewed

    山岡 聖典, 小島 周二, 森 秀治, 澁谷 光一, 竹原 良記

    Radioisotopes   50 ( 2 )   37 - 42   2001

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    Fe3+-NTAを高濃度添加した肺癌由来の培養細胞の場合とは逆に,4μg/ml以下の低濃度で添加した場合,培養細胞の生育はよかった.更にこの培養細胞へFe3+-NTA添加前に0.25Gyの低線量X線を照射しておくと,その良好な生育が促進すると共に,LDHの遊離も抑制した

    DOI: 10.3769/radioisotopes.50.37

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  • 欧州におけるラドン療法の医学的研究に関する最近の動向 Reviewed

    山岡聖典, 御舩尚志

    岡山大学医学部保健学科紀要   12 ( 1 )   7 - 13   2001

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  • Possible Role of Elevation of Glutathione in Acquisition of Enhanced Immune Function of Mouse Splenocytes Exposed to Low-dose γ-rays Reviewed

    Shuji Kojima, Shirane Matsumori, Hirokazu Ishida, Mareyuki Takahashi, Kiyonori Yamaoka

    Excerpta Medica: Radiation and Homeostasis   491 - 494   2001

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  • Prevention of type I diabetes by low-dose gamma irradiation in NOD mice Reviewed

    Mareyuki Takahashi, Shuji Kojima, Kiyonori Yamaoka, Etsuo Niki

    Radiation Research   154 ( 6 )   680 - 685   2000.12

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    Pretreatment with nonlethal, low-dose irradiation has been shown to have a protective effect against oxidative injury in animal tissues, Since oxidative injury of tissues is known to be a major cause of many human diseases, we examined the effect of low-dose irradiation on the progression of type I diabetes in mice, Nonobese diabetic (NOD) mice were treated with gamma irradiation and the progression of the disease was monitored. An elevated level of glucose in urine was first detected at 15 weeks of age in the control NOD mice, whereas the detection was delayed as long as 7 weeks when the mice received a single dose of 0.5 Gy total-body irradiation between 12 and 14 weeks of age. The greatest effect was observed in the mice irradiated at 13 weeks of age, The increase in blood glucose and decrease in blood insulin were effectively suppressed by irradiation at 13 weeks of age. Both suppression of cell death by apoptosis and an increase in superoxide dismutase (SOD) activity were observed in the pancreas 1 week after irradiation. The results indicate that treatment with 0.5 Gy gamma rays suppresses progression of type I diabetes in NOD mice. This is the first report on the preventive effect of low-dose irradiation on disease progression. (C) 2000 by Radiation Research Society.

    DOI: 10.1667/0033-7587(2000)154[0680:POTIDB]2.0.CO;2

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  • Involvement of calcium ion in elevation of mRNA for gamma-glutamylcysteine synthetase (gamma-GCS) induced by low-dose gamma-rays Reviewed

    K Teshima, A Yamamoto, K Yamaoka, Y Honda, S Honda, T Sasaki, S Kojima

    International Journal of Radiation Biology   76 ( 12 )   1641 - 1647   2000.12

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    Purpose. To investigate the mechanism of the intracellular glutathione elevation induced by low-dose gamma -radiation.
    Materials and methods: RAW 264.7 cells were irradiated with 1-400 cGy gamma -rays. Intracellular total glutathione content was determined by DTNB-recycling assay. Expression of mRNA for intracellular glutathione synthesis-related enzymes with or without treatment with Various inhibitors of second messengers of gene expression were examined by Northern blot analysis.
    Results: Expression of mRNA for gamma -glutamylcysteine synthetase (gamma -GCS), a race-limiting enzyme of the de novo glutathione synthesis pathway, was elevated much more than that of glutathione reductase (GR) mRNA after exposure to 50 cGy gamma -rays. The low-dose gamma -ray-induced gamma -GCS mRNA elevation was abolished by inhibitors of protein kinase C and protein tyrosine kinase, as well as by the calcium ion channel blocker, nifedipine. Calcium-related reagents, such BAPTA/AM and EGTA, chelators of intra- and extracellular Ca2+ respectively, and a Ca2+ ionophore (A23187), also strongly blocked the elevation of gamma -GCS mRNA expression induced by gamma -rays.
    Conclusions: The increase of intracellular glutathione in RAW 264.7 soon after low-dose gamma -ray exposure mainly occurs through the operation of the de novo pathway, following by the induction of gamma -GCS mRNA, for which elevation of intracellular calcium is required.

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  • One-step purification of rabbit histidine rich glycoprotein by dye-ligand affinity chromatography with metal ion requirement Reviewed

    Shuji Mori, Masahiro Nishibori, Kiyonori Yamaoka, Motoi Okamoto

    Archives of Biochemistry and Biophysics   383 ( 2 )   191 - 196   2000.11

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    A simple method for purification of the histidine rich glycoprotein (rHRG) from rabbit sera was developed. The rHRG was purified by one-step affinity chromatography using the triphenylmethane dye 'acid fuchsin' as a specific ligand, which gave an overall yield above 80%. Interestingly, the binding of rHRG to the ligand required the divalent transition-metal ions such as Zn2+, Ni2+, and Co2+ at pH 9.5. In the presence of 0.5 mM ZnCl2, the binding was enhanced 15 times compared with that in the absence of ZnCl2. Bound rHRG was efficiently eluted from the affinity absorbent with 100 nM imidazole or histidine. Purified rHRG was homogeneous with an M(r) of 94 kDa when analyzed by SDS-PAGE, whereas isoelectric focusing revealed microheterogeniety with pI values ranging from 6.3 to 6.8. Blotting analysis with lectins specific for carbohydrate moieties and treatment with glycosidases demonstrated that rHRG is a highly N-glycosylated protein with diverse carbohydrate structures. (C) 2000 Academic Press.

    DOI: 10.1006/abbi.2000.2032

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  • Induction of Endogenous Antioxidant System by Low Dose Radiation and its Applicable Possibility for Treatment of Active Oxygen Species Related Diseases Reviewed

    Kiyonori Yamaoka

    Bull Fac. Health Sci., Okayama Univ. Med. Sch   11 ( 1 )   1 - 15   2000.2

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  • Induction of Endogenous Antioxidant System by Low Dose Radiation and its Applicable Possibility for Treatment of Active Oxygen Species RelatedDiseases Reviewed

    K.Yamaoka

    Bull Fac. Health Sci., Okayama Univ. Med. Sch.   11 ( 1 )   1 - 15   2000

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  • 低線量放射線の不思議な生体作用-ラドン温泉が効くわけを探る- Invited Reviewed

    山岡聖典, 小島周二

    現代化学   346   24 - 30   2000

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  • Elevation of antioxidant potency in the brain of mice by low-dose gamma-ray irradiation and its effect on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced brain damage Reviewed

    S Kojima, O Matsuki, T Nomura, K Yamaoka, M Takahashi, E Niki

    Free Radical Biology and Medicine   26 ( 3-4 )   388 - 395   1999.2

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    The elevation of endogenous thiol-related antioxidants and free radical scavenging enzymes in the brain of C57BL/6 female mice after low-dose gamma-ray irradiation and its inhibitory effect on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced brain damage were investigated. The brain level of the reduced form of glutathione (GSH) increased soon after irradiation with 50 cGy of gamma-rays, reached a maximum at 3 h post-treatment, and remained elevated until 12 h. Thioredoxin (TRX) was also transiently increased after irradiation. The activities of free radical scavenging enzymes, including Cu/Zn-superoxide dismutase, catalase and glutathione peroxidase, were significantly induced after irradiation as well. Cerebral malondialdehyde was remarkably elevated by MPTP treatment, and this elevation was suppressed by pre- irradiation (50 cGy). The contents of GSH and TRX were significantly decreased by MPTP treatment in comparison with those of the control group. These reductions both seemed to be attenuated by pre-irradiation with gamma-rays. These results suggest that low-dose gamma-ray irradiation induces endogenous antioxidative potency in the brain of mice and might be effective for the prevention and/or therapy of various reactive oxygen species-related neurodegenerative disorders, such as Parkinson's disease and Alzheimer's disease. (C) 1998 Elsevier Science Inc.

    DOI: 10.1016/S0891-5849(98)00200-7

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  • Rationalization of measures to protect the working environment in radiation controlled areas from the perspective of the relationship between surface and airborne contamination. Reviewed

    岡山大学医学部保健学科紀要   10 ( 1 )   1 - 13   1999

  • Oxygen concentration regulates NO-dependent relaxation of aortic smooth muscles Reviewed

    Y Takehara, H Nakahara, S Okada, K Yamaoka, K Hamazaki, A Yamazato, M Inoue, K Utsumi

    Free Radical Research   30 ( 4 )   287 - 294   1999

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    Nitric oxide (NO) functions as an endothelium-derived relaxation factor and regulates vascular resistance. Recent studies in this laboratory (Arch. Biochem. Biophys. 323, 27-32, 1995) revealed that the lifetime of NO significantly increased at physiologically low levels of oxygen concentrations and, hence, this gaseous radical strongly inhibited mitochondrial electron transport for a fairly long duration at low oxygen concentrations. The present work describes the effect of oxygen concentration on NO-induced relaxation and guanylate cyclase (GC) activity of endothelium-denuded aorta of the rat. Both NO and 2,2'-(hydroxynitrosohydrazono)bis-ethanamine (NOC18), an NO donor, induced the relaxa-tion of endothelium-denuded helical segments of rat aorta which were contracted by norepinephrine. NO-dependent relaxation of arterial specimens was enhanced by lowering oxygen concentration in the medium with concomitant increase in their cGMP levels. Anoxia induced the relaxation of the aorta by some NO-enhanceable and methylene blue-insensitive mechanism. These results suggested that local concentrations of oxygen might play important roles in the regulation of NO-dependent GC activity and vascular tonus of resistance arteries.

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  • Adaptive responses of living cells towards low-doses of radiation; Induction of endogenous antioxidant system and its applicable possibility for treatment of diseases Reviewed

    45 ( 3 )   133 - 143   1999

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  • Localization of glutathione and induction of glutathione synthesis-related proteins in mouse brain by low doses of gamma-rays Reviewed

    S Kojima, O Matsuki, T Nomura, N Shimura, A Kubodera, K Yamaoka, H Tanooka, H Wakasugi, Y Honda, S Honda, T Sasaki

    Brain Research   808 ( 2 )   262 - 269   1998.10

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    First, we determined the cerebral localization of reduced glutathione (GSH) in normal mice by means of autoradiography using Tc-99m-meso-hexamethyl propylene oxime. A highly specific localization of GSH in the cerebellum and hippocampus was observed. Secondly, we measured the elevation of GSH level in the brain after low-dose gamma-irradiation. The cerebral GSH levels increased soon after irradiation with 50 cGy of gamma-rays, reaching a maximum at 3 h post-treatment, then remaining significantly higher than that of the non-irradiated control until 12 h and returning to the control level by 24 h. Thirdly, we examined the induction of the activities and the mRNAs of proteins involved in the synthesis and regeneration of GSH in the brain of mice subjected to low-dose gamma-ray irradiation. The level of mRNA for gamma-glutamylcysteine synthetase was significantly increased at 0.5 h, and remained high until 2 h post-irradiation (50 cGy). The level was transiently lowered to the non-irradiated control level at 3 h and slightly increased again after 6 h post-irradiation. gamma-Glutamylcysteine synthetase activity was significantly increased 3 h after irradiation, and remained high up to 24 h post-irradiation. As for glutathione reductase, the mRNA level was increased at 0.5 h, and peaked strongly at 2 h, while the enzyme activity was significantly increased at 6 h after irradiation, and continued to increase up to 24 h. The level of mRNA for thioredoxin, which contributes to GSH biosynthesis by supplying cysteine to the de novo pathway, peaked between 0.5 h and 2 h post-irradiation, and rapidly declined thereafter. The content of thioredoxin showed a transient decrease immediately after irradiation, but was then remarkably elevated, reaching a maximum at 3 h, and thereafter declining sharply. These results indicate that the increase in endogenous GSH in mouse brain soon after low-dose gamma-ray irradiation is a consequence of the induction of GSH synthesis related proteins and occurs via both the de novo synthesis and the regeneration pathways. (C) 1998 Elsevier Science B,V, All rights reserved.

    DOI: 10.1016/S0006-8993(98)00832-4

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  • Effect of Small-dose γ-ray on Endogenous Antioxidant Enzymes in Mice Reviewed

    47 ( 4 )   291 - 299   1998

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  • Indication for Radon Therapy at Badgastein and Elucidation of Its Mechanism. Invited Reviewed

    47 ( 9 )   59 - 60   1998

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  • Cold-Stress Induces Thymocyte Apoptosis in the Rat Reviewed

    S.Morishita, Y.Nishi, E.F.Sato, K.Yamaoka, M.Manabe, M.Inoue

    Pathophysiology   47 ( 3 )   213 - 219   1997

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    Although various stresses have been known to induce atrophy of the thymus, its pathogenesis remains to be clarified. To elucidate the mechanism of stress-induced atrophy of the thymus, possible involvement of thymocyte apoptosis was studied using rats which were exposed to cold environment. Exposure to cold temperature (5°C) for 4 h induced the fragmentation of thymocyte DNA in fasted rats but not in fed animals. Glucose levels in the blood and the body temperature of both fasted and fed rats markedly decreased during the exposure to cold temperature. Cold-stress significantly increased the plasma levels of corticosterone in fasted rats by some mechanism which was suppressed by feeding. The cold-stress-induced apoptosis was inhibited by either adrenalectomy or administration of RU486, a glucocorticoid receptor antagonist. Administration of glucose (7.5 g/kg body weight) also prevented the stress-induced apoptosis of thymocytes. These results suggested that cold-stress might enhance the secretion of glucocorticoid from the adrenal gland and induce apoptosis of thymocytes by some glucose-inhibitable mechanism.

    DOI: 10.1016/S0928-4680(97)00021-7

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  • Influence of Low-dose X-irradiation on Cell Membrane Fluidity of Human Fibroblast Reviewed

    Keiichiro Ishii, Kiyonori Yamaoka

    Lipid Peroxide Research   21 ( 2 )   96 - 97   1997

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  • Studies on the biological effects of chemical defense mechanisms in vivo activated by low-dose irradiation Reviewed

    T46   1996.10

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  • 進む放射線ホルミシスの解明 Invited Reviewed

    山岡聖典, 石田健二

    OHM   83 ( 4 )   84 - 88   1996.4

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  • Low Dose X-ray Irradiation Induces Stress Proteins but does not Prevent Gastric Mucosal Lesion Reviewed

    E.F.Sato, K.Yamaoka, H.Yu, S.Morishita, M.Inoue

    Physiological Chemistry & Physics and Medical NMR   28 ( 2 )   103 - 109   1996

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    We studied the effect of low dose X-ray irradiation on the expression of stress proteins and gastric mucosal lesion. Low X-ray irradiation induced the expression of mRNA for heme oxygenase in adrenal and stomach. The expression hsp70 mRNA was also induced by low dose X-ray irradiation in the adrenal gland but not in the stomach. However, the expression of Mn-SOD mRNA was not changed in either tissue by low dose X-ray irradiation. Nor was WIR stress-induced gastric mucosal lesion prevented by pre-irradiation. These data suggest that low dose X-ray irradiation induced stress proteins in some specific tissues only. It did not prevent the gastric mucosal lesion.

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  • Study on Effects of Vitamin E and Low-dose X-irradiation on Lipid Peroxides in Cells Reviewed

    K.Yamaoka, K.Ishii

    Lipid Peroxide Research   19 ( 2 )   90 - 92   1995.10

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  • Enhanced Mitogen-induced Prolification of Rat Splenocytes by Low-dose Whole-body X-irradiation Reviewed

    K.Ishii, K.Yamaoka, Y.Hosoi, T.Ono, K.Sakamoto

    Physiological Chemistry & Physics and Medical NMR   27 ( 1 )   17 - 23   1995

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    To elucidate the stimulative effect on the immune system, we studied the effect of acute low-dose whole-body X-irradiation on the mitogen-induced proliferative responses of rat splenocytes and thymocytes. Concanavalin A (Con A)-induced mitogen response of rat splenocytes 4 hours after 5 cGy irradiation was significantly higher (by 80%, p < 0.02) than that in sham-irradiated controls; whereas that of rat thymocytes did not show change after irradiation of 1-10 cGy. In the rats X-irradiated with doses greater than 25 cGy, Con A-induced mitogen responses of splenocytes and thymocytes were reduced. In a way similar to the Con A-induced mitogen response of splenocytes, the mitogen response of splenocytes induced by phytohemagglutinin (PHA) or lipopolysaccharide (LPS) was significantly increased by X-irradiation with 5 cGy (by 50%, p < 0.02). The enhancement of mitogen response of splenocytes was observed within a few hours after irradiation, being a temporary effect. After 5 cGy irradiation the level of leukotriene B4 (LTB4) in the supernatant fraction of the splenocyte suspension showed a significant increase (by 40%, p < 0.05).

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  • Protection against Alloxan Diabetes by Low Dose γ-irradiation before Alloxan Administration Reviewed

    Y.Takehara, K.Yamaoka, Y.Hiraki, T.Yoshioka, K.Utsumi

    Physiological Chemistry & Physics and Medical NMR   27 ( 3 )   149 - 159   1995

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  • Effect of low-dose X-ray irradiation on membrane fluidity of human fibroblasts Reviewed

    K.Ishii, K.Yamaoka

    Lipid Peroxide Research   19 ( 2 )   96 - 98   1995

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  • ラドン泉吸入によるウサギ脳内の生体アミンの変化 Reviewed

    山岡聖典, 古元嘉昭, 鈴鹿伊智雄, 枝松礼, 森 昭胤

    過酸化脂質研究   18 ( 2 )   201 - 204   1995

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  • 低線量γ線照射によるアロキサン糖尿病症状の抑制効果 Reviewed

    山岡聖典, 竹原良記, 吉岡保, 内海耕慥

    電力中央研究所研究報告   T94004   1994.10

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  • 遺伝子解析による活性酸素代謝系蛋白測定法の確立とその適用 Reviewed

    山岡聖典, 佐藤英介, 井上正康

    電力中央研究所研究報告   T93055   1994.5

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  • EFFECTS OF LOW-DOSE X-RAY-IRRADIATION ON BIOMEMBRANE IN BRAIN CORTEX OF AGED RATS Reviewed

    K YAMAOKA, R EDAMATSU, T ITOH, A MORI

    T93006   1994.4

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    We previously found that low-dose X-ray irradiation or radon (weak alpha-ray) inhalation increases SOD activities and reduces lipid peroxide levels in various organs of 7-week-old rats or rabbits. In this study, we examined how the changes of SOD activity, lipid peroxide level, and membrane fluidity of the cerebral cortex in aged male Wistar rats (65 and 91 weeks old) were affected by low-dose X-ray irradiation (100 cGy or under) compared with those in 7-week-old rats, to elucidate the mechanism of aging inhibition. The following results were obtained: Although radiation sensitivity was observed to decreases with age, low-dose irradiation changed the Mn-SOD activity, lipid peroxide level, and membrane protein fluidity parameter of the cerebral cortex in the aged rats to be closer to those in the youth. These findings suggest that the increased SOD activity induced by low-dose irradiation enhances biomembrane functions, and that the decrease of lipid peroxide level enhances the membrane protein fluidity.

    DOI: 10.1016/0891-5849(94)90132-5

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  • Study on Effects of Low Dose Radiation on Biological Function Reviewed

    T34   1994.4

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  • DNA Damage by Various Forms of Active Oxygens and its Inhibition by Different Scavengers using Plasmid DNA Reviewed

    Y.Takehara, K.Yamaoka, E.F.Sato, T.Yoshioka, K.Utsumi

    Physiological Chemistry & Physics and Medical NMR   26 ( 3 )   215 - 226   1994

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  • Changes in Biogenic Amine Neurotransmitters in Rabbits Brain by Inhalation of Radon Spring Reviewed

    K.Yamaoka, K.Ishii, T.Ito, Y.Komoto, I.Suzuka, R.Edamatsu, A.Mori

    Neurosciences   20 ( 1 )   17 - 22   1994

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  • ラドン泉吸入の生体機能に及ぼす影響ー家兎における過酸化とSOD活性― Reviewed

    山岡聖典, 古元嘉昭, 鈴鹿伊智雄, 枝松礼, 森 昭胤

    過酸化脂質研究   17 ( 3 )   271 - 273   1993.10

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  • Study on Inhibition of DNA Damage by SOD. Reviewed

    T92071   1993.4

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  • Effects of Low Dose X-ray Irradiation on Aged Rats. Reviewed

    T92013   1992.12

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  • 放射線ホルミシス Reviewed

    服部禎男,石田健二,山岡聖典

    原子力学会誌   34   688 - 696   1992.7

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  • Study on mechanism of Increased SOD Activity by Low Dose Radiation; Elucidation on Induction of SOD. Reviewed

    T91047   1992.5

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  • Study on Inhibition of Hypertention by Low Dose Radiation. Effect of HB-SOD on Blood Pressure of SHR. Reviewed

    山岡聖典, 中園光一, 渡辺信和, 井上正康

    電力中央研究所狛江研究所報告   T91042   1992.5

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  • Possible Interferenceof Low Molecular Compound within a Measurement of SOD Activity using Electron Spin Resonance

    R.Edamatsu, K.Yamaoka, A.Mori

    Magnetic Resonance in Medicine   31   126 - 128   1992.5

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  • Enhancement of Bio-functions by low Dose Irradiation. Enhancement of Cell Membrane Fluidity. Reviewed

    T91005   1991.11

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  • Adrenal Secretion of Catecholamines by Inhalation of Radon Water in Relation to Increase of Tissue Reviewed

    I.Suzuka, K.Yamaoka, Y.Komoto

    Journal of Japanese College of Angiology   31   1182 - 1187   1991.9

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  • Study on Mechanism of Decreased Lipid Peroxide by low dose Radiation: Effect of SOD on the Lipid Peroxidation in biomembrane. Reviewed

    T90060   1991.6

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  • Vasoactive effects and decreased lipid peroxides by radon inhalation on rabbits. Reviewed

    T90007   1990.10

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  • Basic study on low dose radiation effects. Increased SOD activities and decreased lipid peroxides. Reviewed

    T89063   1990.5

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  • COMPARISON OF POPULATION PHARMACOKINETICS MODELS BY MULTI (ELS) ON PERSONAL-COMPUTER Reviewed

    K YAMAOKA, H TANAKA

    Advances in Therapeutic Drug Monitoring   72 - 75   1990

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  • Basic study on low dose radiation effect: SOD activity of immune organs and hemogram in rats. Reviewed

    T89002   1989.6

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  • 低レベル廃棄物の分別管理システムに関する検討(第1報) Reviewed

    山岡聖典, 根本和泰, 尾崎幸男, 讃井敏光

    電力中央研究所研究報告   A84010   1985.5

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  • 紫外部チェレンコフ光による使用済燃料集合体の確認法 Reviewed

    中岡章, 山岡聖典, 栗原雅幸, 福島政法

    電力中央研究所研究報告   A83003   1983.4

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Books

  • 教科書 改訂版:環境と健康を科学する

    山岡聖典( Role: Sole author)

    健康新聞社(東京)  2017.3  ( ISBN:9784882698524

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  • “Mitigating effects of radon inhalation on neuropathic pain in mice and its possible application in veterinary care” in Neuropathic Pain

    Takahiro Kataoka, Norie Kanzaki, Kaori Sasaoka, Kiyonori Yamaoka

    Avid Science  2016 

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  • “Possible applications of radon therapy in veterinary care for oxidative stress-induced kidney damage” in Free Radicals and Health

    Kaori Sasaoka, Takahiro Kataoka, Norie Kanzaki, Kiyonori Yamaoka

    Nova Science Publishers, Inc.  2016  ( ISBN:9781536101

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  • “The possible applications of radon inhalation treatment as antioxidant therapy for hepatopathy” in Radon: Geology, Environmental Impact and Toxicity Concerns

    T.Kataoka, A.Sakoda, R.Etani, Y.Ishimori, F.Mitsunobu, K.Yamaoka(pp.133-148)

    Nova Science Publishers, Inc.  2015.1 

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  • 放射能泉の安全に関するガイドブック

    山岡聖典(放射能泉と健康)

    健康と温泉フォーラム(東京)  2012  ( ISBN:9784990469412

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  • ”Activation of Bio-defense System by Radon Inhalation and its Applicable Possibility for Treatment of Lifestyle Diseases” in Handbook of Radon

    T.Kataoka, A.Sakoda, Y.Ishimori, F.Mitsunobu, K.Yamaoka

    Nova Science Publishers, Inc.  2012 

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  • 教科書 放射線実験学

    山岡聖典,花元克巳,川辺 睦,片岡隆浩,迫田晃弘

    岡山大学出版会  2010.9  ( ISBN:9784904228159

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  • 研究者たちの発信

    山岡聖典他

    to be 出版  2008.11  ( ISBN:9784990269586

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  • 大自然の三大健康浴-森林浴・温泉浴・岩盤浴-

    山岡聖典

    健康新聞社  2008.4 

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  • 教科書 環境と健康を科学する

    山岡聖典( Role: Sole author)

    健康新聞社(東京)  2005.4  ( ISBN:4882695774

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    Total pages:175   Language:Japanese

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  • 低線量放射線影響-疫学と放射線生物学の接点を求めて-

    山岡聖典他

    日本工業新聞社  2004 

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  • 低線量放射線の健康影響ーがんリスクはあるか?ー

    山岡聖典他

    電気新聞特別号  2003.12 

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  • Molecular Mechanisms for Radiation-induced Cellular Response and Cancer Development

    K.Yamaoka, S.Kojima(pp.210-226)

    Environmental Sciences  2003.4 

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  • Biological Effects of Low Dose Radiation: Activation of Chemical Biological Defense Mechanisms and Alleviation of in vivo Oxidation Injuryby Low Dose Radiation

    Kiyonori Yamaoka, Shuji Kojima(pp.210-216)

    Institute for Environmental Sciences  2002.10 

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  • Radiation and Homeostasis: Scientific Basis of Risk Assessment and the Mechanism of Radiation Carcinogenesis-

    K.Yamaoka, S.Kojima, T.Nomura

    Elsevier Science (Amsterdam)  2002.4 

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  • Harmonization of Radiation, Human Life and Ecosystem

    K.Yamaoka, T.Nomura, S.Kojima

    International Radiation Protection Association  2000.5 

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  • Radon und Gesundheit

    K.Yamaoka, S.Hattori, P.Deetjen, A.Falkenbach

    Peter Lang GmbH (Frankfurt)  1999.9 

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  • Health Effects of Low Dose of Ionizing Radiation

    S.Kojima, O.Matuki, K.Yamaoka

    Internationa Atomic Energy Agency  1997.11 

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  • フリーラジカルの臨床

    近藤元治, 浅田浩二, 岡田 茂, 小川紀雄, 山岡聖典

    日本医学館  1996.12 

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  • 放医研シンポジウムシリーズ No.27:活性酸素・フリーラジカル研究の新展開ー基礎から臨床までー:生体防御機構

    山岡聖典(pp.97-112)

    放射線医学総合研究所  1996.9 

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  • 放射線ホルミシスⅡ-ヒトおよび動物のデータを中心に-

    松平寛通, 石井敬一郎, 大山ハルミ, 栗原靖之, 佐藤温吉郎, 佐藤鐡也, 色田幹雄, 藤井由布, 古野育子, 御園生 淳, 宮地幸久, 山岡聖典, 山田武

    ソフトサイエンス社  1993.7  ( ISBN:4881710486

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  • Low Dose Irradiation and Biological Defense Mechanisms

    K.Yamaoka, R.Edamatu, A.Mori(pp.419-422)

    Elsevier Science (Amsterdam)  1992.12 

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  • Oxygen Radicals

    K.Yamaoka, Y.Komoto, I.Suzuka, R.Edamatsu, A.Mori(pp.777-780)

    Excerpta Medica (Amsterdam)  1992.10 

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  • トロン浴で健康増進

    山岡聖典

    法研(東京)  2011.9 

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  • 教科書 RI実験の手引き 第3版

    山岡聖典, 澁谷光一, 花元克巳, 川辺睦, 迫田晃弘, 水口優子

    岡山大学医学部保健学科  2007.4 

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  • トロンで健康ライフ

    山岡聖典

    法研(東京)  2006 

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  • 遠赤外線とマイナスイオンの科学と展望

    金 宗哲, 山岡聖典, 韓 忠珠, 佐野 洋, 金 振寥

    日本遠赤外線応用研究会・韓国遠赤外線協会  2004 

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  • Radiation and Homeostasis: Elevation of antioxidants in the kidneys of mice by low- dose irradiation and its effect on Fe3+-NTA-induced kidney damage

    T.Nomura, K.Yamaoka, K.Sakai(pp.481-485)

    Elsevier Science (Amsterdam)  2002.4 

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  • 自然と健康

    山岡聖典他

    日本ジャーナル出版  2002 

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  • 放射線と健康

    山岡聖典他

    放射線と健康を考える会  2001 

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  • Bioradicals

    K.Yamaoka, T.Obata, H.Kamada, H.Ohya

    Yamagata Technopolis Foundation  1998.6 

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  • Radon and Thoron in the Human Environment

    K.Yamaoka, Y.Komoto, A.Katase, M.Shimo

    Tohwa University  1998.3 

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  • DENCHUKEN REVIEW:放射線ホルミシス-研究の意義と取り組み-

    石田健二, 石井敬一郎, 山岡聖典

    電力中央研究所  1996.3 

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  • 電中研レビュー:放射線ホルミシス 研究の意義と取り組み

    石田健二, 山岡聖典, 他

    電力中央研究所  1996.3 

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  • Possible Interference of Low Molecular Compound within a Measurement of SOD Activity using Electron Spin Resonance

    R.Edamatu, K.Yamaoka, A.Mori

    Magnetic Resonance in Medicine  1990.5 

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MISC

  • 理事会だより:支部活動の今後の在り方を考える

    山岡聖典

    日本原子力学会誌   64 ( 4 )   54 - 54   2022.4

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  • 巻頭言 改めて放射線教育と研究の重要性を考える Invited

    山岡聖典

    鹿田施設ニュース   14   1 - 1   2021.3

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  • コロナ感染症と低線量放射線 Invited

    山岡聖典

    月刊エネルギーレビュー   40 ( 9 )   3 - 3   2020.9

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  • 鹿田施設におけるラドン療法の新規適応症の探索とその機構解明 Invited

    片岡隆浩, 山岡聖典

    鹿田施設ニュース   14   5 - 12   2019.12

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  • 特別寄稿 低線量放射線の健康効果を科学する-ラドン療法を中心に-③ Invited

    山岡聖典

    JAPI Newsletter   19 ( 6 )   2 - 4   2017.1

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  • 特別寄稿 低線量放射線の健康効果を科学する-ラドン療法を中心に-② Invited

    山岡聖典

    JAPI Newsletter   19 ( 5 )   2 - 5   2016.11

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  • 低線量放射線の健康影響 ラドン温泉の健康効果とそのリスク ラドン療法の適応症に関する機構解明と新規探索 Invited

    山岡 聖典, 片岡 隆浩

    日本放射線影響学会第59回大会ワークショップ講演要旨集   2016.10

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    J-GLOBAL

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  • 特別寄稿 低線量放射線の健康効果を科学する-ラドン療法を中心に-① Invited

    山岡聖典

    JAPI Newsletter   19 ( 4 )   7 - 10   2016.9

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  • 低線量放射線と温熱の健康増進効果 Invited

    山岡 聖典

    Thermal Medicine   30 ( 3 )   71 - 71   2014.9

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  • 健康長寿の湯:三朝温泉

    山岡聖典

    ミササスタイル(鳥取県三朝町)   20 - 23   2013.7

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  • 低線量放射線の健康影響と医療応用 Invited

    山岡聖典

    日本アイソトープ協会ライフ サイエンス部会・理工学部会共催エンライトニングセミナー教育講演抄録集   2013.7

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  • 微量放射線と生体の適応応答 ラドンガスに健康増進の抗酸化力 Invited

    山岡聖典

    自然食ニュース   475   4 - 17   2013.6

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  • 知らないことによる不幸 Invited

    山岡聖典

    月刊エネルギーレビュー   33 ( 3 )   3 - 3   2013.3

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  • 低線量放射線の健康への影響と医療・健康増進への応用の可能性 Invited

    山岡聖典

    日本放射線安全管理学会学術第9回大会特別講演予稿集   16 - 16   2010.12

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  • 低線量放射線の健康への影響と医療への応用,およびその関連に関する研究 Invited

    片岡隆浩, 迫田晃弘, 花元克巳, 川辺 睦, 山岡聖典

    鹿田施設ニュース   5 ( 1 )   4 - 9   2010.7

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  • ラドンの健康効果に関する最近の研究動向 Invited

    山岡聖典

    日本機能性イオン協会会報誌 i-press   16 ( 1 )   2 - 7   2010.5

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  • 生活習慣病に風穴を開ける低線量(少量)放射線 Invited

    山岡聖典

    ニューライフ   56 ( 10 )   36 - 39   2009.10

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  • 放射線ホルミシスによる健康効果 Invited

    山岡聖典

    ニューライフ   56 ( 9 )   15 - 18   2009.9

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  • 巻頭言 発展が期待される鹿田施設 Invited

    山岡聖典

    鹿田施設ニュース   4   1 - 1   2009.7

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  • 低線量事前照射で脳浮腫が抑制 Invited

    山岡聖典, 吉本雅章

    Medical Tribune誌   42 ( 8 )   44 - 44   2009.2

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  • ラドンによる低線量放射線の医療・ヘルスプロモーション(健康増進)への応用 Invited

    山岡聖典

    ヘルスライフビジネス   460   13 - 13   2009.2

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  • 低線量ラドンの健康効果を解明する-放射線ホルミシス効果の医療・健康増進への応用の可能性- Invited

    山岡聖典

    未来へげんき((国研)日本原子力研究開発機構広報誌)   10   6 - 7   2008.10

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  • ラドン療法とその機構 Invited

    山岡聖典

    放射線教育フォーラム2008年度第1回勉強会講演資料   1 - 10   2008.6

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  • エネルギー・環境 最前線:放射線の不思議な生体作用 Invited

    山岡聖典

    エネルギーフォーラム   ネット   2008

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  • 研究紹介 ラドン療法の適応症と機構解明の現状 Invited

    山岡聖典

    くらしと放射線   21   14 - 24   2007.10

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  • ストレスと生体応答:ラドン温泉療法の適応症とその機構 Invited

    山岡聖典

    日本ハイパーサーミア学会第22回大会シンポジウム抄録集   21   67 - 67   2005.9

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  • Simplification of analysis for comparison of radioactive characteristics and its application to some minerals for radon therapy Reviewed

    K.Hanamoto, K.Yamaoka

    RADIATION DOSE AND HEALTH EFFECTS   1276   253 - 255   2005.2

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    To simplify the analysis of the radioactive characteristics of the minerals for the radon therapy, we developed a simple method to calculate the ratio of the uranium series to the thorium series (U/Th) without using activity. The ratios calculated by this method agreed well with the ratios calculated using the activity. We applied this method to some minerals for the radon therapy. As a result, the U/Th&apos;s for the sludge of Misasa, the hokutolite, the mineral of Badgastein, and the two kinds of commercially available minerals were 22, 50, 0.94, 0.26, and 0.20, respectively. (c) 2004 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.ics.2004.09.029

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  • Effects of radon and thermal therapy on osteoarthritis Reviewed

    K.Yamaoka, F.Mitsunobu, K.Hanamoto, T.Kataoka, Y.Tanizaki

    RADIATION DOSE AND HEALTH EFFECTS   1276   249 - 250   2005

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    We examined the temporal changes in antioxidants, immune-, vasoactive- and pain-associated substances in human blood by therapy to elucidate the mechanism of osteoarthritis in which radon therapy is used as a treatment. Results showed that radon inhalation enhanced the antioxidation and immune function, and that the changes in vasoactive and pain-associated substances indicate increases in tissue perfusion brought about by radon therapy. (c) 2004 Published by Elsevier B.V.

    DOI: 10.1016/j.ics.2004.12.013

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  • ラドン温泉効果とマイナスイオン効果との関係に関する検討-それぞれの適応症とその機構の相関性-

    山岡聖典, 光延文裕, 花元克巳

    過酸化脂質研究   27 ( 1 )   64 - 64   2003.10

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  • Activation of chemical biological defense mechanisms and alleviation of in vivo oxidation injury by low dose radiation Reviewed

    K. Yamaoka, S. Kojima

    Molecular Mechanisms for Radiation-induced Cellular Response and Cancer Development Towada, Art Press Co. Ltd   210 - 216   2003

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  • 低線量放射線の生体影響研究 高バックグラウンド研究から宇宙研究へ 高自然放射線環境の健康影響とその機構 ラドン療法の適応症とその機構解明の現状を中心に Invited

    山岡 聖典

    日本放射線影響学会第45回大会ワークショップ講演要旨集   70 - 70   2002.9

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  • 三朝ラドン温泉適応症の機構に関する検討 Invited

    山岡聖典

    放射線と健康を考える会誌   6   2 - 12   2002.9

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  • Basic study on the radon effects and the thermal effects in radon therapy Reviewed

    Kiyonori Yamaoka, Takashi Mifune, Shuji Kojima, Shuji Mori, Koichi Shibuya, Yoshiro Tanizaki, Katsuhiko Sugita

    Radiation and Homeostasis   1236   75 - 79   2002.7

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    Because most of the diseases to which radon therapy is applied are related with activated oxygen, in this study, the effects of the radioactivity of radon and the thermal effects were compared under condition with the same chemical effects using the activity of superoxide dismutase (SOD), which is an oxidation inhibitor, and lipid peroxide and low-density lipoprotein (LDL)-cholesterol, which are closely involved in arteriosclerosis, as the parameters. The results were as follows, the SOD activity was significantly increased, and the lipid peroxide and LDL-cholesterol levels were significantly decreased on days 6 and 7. The results were about twofold larger in the radon group than in the thermo group. This suggests that the antioxidation function was more enhanced by radon therapy than by thermo therapy, and it was suggested that radon therapy may prevent the causes of lifestyle-related diseases such as arteriosclerosis. These findings are important in understanding the mechanism of diseases to which radon therapy can be performed, and most of which are called activated oxygen-related diseases. © 2002 Elsevier Science B.V.

    DOI: 10.1016/S0531-5131(02)00311-4

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  • 欧州におけるラドン療法の医学的研究の動向 Invited

    山岡聖典, 御舩尚志

    放射線と健康を考える会誌   4   2 - 10   2002.3

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  • 温泉入浴法 Invited

    松浦邦雄, 久保田一雄, 山岡聖典

    自然と健康   9 ( 1 )   120 - 127   2002.1

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  • ラドン温泉が効く訳を探る Invited

    山岡 聖典

    放射線と健康を考える会誌   2   2 - 13   2001.3

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  • 原子力最前線-放射線ホルミシス- Invited

    山岡聖典

    Energia   592   30 - 41   2001

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  • Suppression of ROS-related disease in mouse models by low-dose γ-ray irradiation Reviewed

    T. Nomura, K. Sakai, S. Kojima, M. Takahashi, K. Yamaoka

    Biological Effects of Low Dose Radiation, Excerpta Medica   1211   101 - 106   2000

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  • Induction of glutathione in mouse brain by low dose of γ-rays Invited

    S. Kojima, K. Yamaoka

    Biological Effects of Low Dose Radiation, Excerpta Medica   1211   117 - 127   2000

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  • Activation of chemical biological defense mechanisms and remission of vital oxidative injury by low dose radiation Reviewed

    K.Yamaoka, T.Nomura, S.Kojima

    IRPA-10   1 - 10   2000

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  • Effects of Low Dose X-ray Irradiation on Purine Metabolism and Prostaglandins Production in Mice

    K.Yamaoka, E.Niki, T.Obata, K.Iriyama, M.Takahashi

    Proceedings of 2nd International Conference on Biologicals   63 - 65   1997.10

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  • Effect of small doses of γ-ray on the glutathione synthesis in mouse, In Low doses of ionization radiation: Biological Effects and Regulatory Control Invited

    S.Kojima, O.Matsuki, T.Nomura, M.Takahashi, K.Yamaoka

    IAEA-TECDOC-976   417 - 420   1997

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  • Message from molecular natural history: Purine-pyrimidine metabolism system Invited

    入山啓治, 小幡徹, 石岡憲昭, 山岡聖典

    化学工業   47 ( 4 )   69 - 79   1996.4

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  • 現代医学の最前線 低線量γ線照射で糖尿病発症を抑制 Invited

    山岡聖典, 石田健二

    キッセイクール   13 ( 5 )   13 - 14   1995.10

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  • Suppression of Aging by Low Dose Radiation.

    山岡聖典

    理工学における同位元素研究発表会パネル討論要旨集   32nd   258 - 261   1995.7

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  • Special issue : Search for radiation hormesis.Details of radiation hormesis research in Central Res. Inst. of Electric Power Industry.

    石田健二, 御園生淳, 石井敬一郎, 山岡聖典

    原子力工業   39 ( 9 )   8 - 33   1993.9

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  • Effects of low-dose X-irradiation on oxidative stress induced by forced swim test in some organs

    Shota Naoe, Takahiro Kataoka, Yuki Fujimoto, Kaito Murakami, Ryohei Yukimine, Ayumi Tanaka, Kiyonori Yamaoka

    2022.9

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  • Combined inhibitory effects of thoron inhalation and ascorbic acid administration on alcohol-induced hepatopathy in mice

    Takahiro Kataoka, Tsuyoshi Ishida, Shota Naoe, Norie Kanzaki, Akihiro Sakoda, Hiroshi Tanaka, Fumihiro Mitsunobu, Kiyonori Yamaoka

    2022.9

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  • Changes in sulfur-related metabolites in mouse lungs following radon inhalation

    Norie Kanzaki, Akihiro Sakoda, Takahiro Kataoka, Kiyonori Yamaoka

    2022.9

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  • 低線量X線照射と強制水泳試験がマウス各組織に及ぼす酸化ストレスの影響に関する比較検討

    藤本有希, 片岡隆浩, 直江翔太, 村上海斗, 雪峰諒平, 山岡聖典

    第59回アイソトープ・放射線研究発表会要旨集   2022.7

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  • プロテオーム解析によるラドン吸入マウス脳の酸化ストレス関連タンパク質の変化特性に関する検討

    雪峰諒平, 片岡隆浩, 直江翔太, 村上海斗, 藤本有希, 神﨑訓枝, 迫田晃弘, 宮地孝明, 山岡聖典

    第59回アイソトープ・放射線研究発表会要旨集   2022.7

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  • ラドンの細胞培養用培地における溶解・散逸特性に関する基礎的検討

    村上海斗, 片岡隆浩, 直江翔太, 藤本有希, 雪峰諒平, 神﨑訓枝, 迫田晃弘, 寺東宏明, 山岡聖典

    第59回アイソトープ・放射線研究発表会要旨集   2022.7

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  • ラドン吸入が正常と関節リウマチマウスのサイトカイン代謝に及ぼす影響に関する比較検討

    直江翔太, 片岡隆浩, 村上海斗, 雪峰諒平, 藤本有希, 神﨑訓枝, 迫田晃弘, 光延文祐, 山岡聖典

    第59回アイソトープ・放射線研究発表会要旨集   2022.7

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  • トロン吸入のアスコルビン酸投与併用による急性アルコール性肝障害の抑制とラドン吸入との比較

    片岡隆浩, 石田 毅, 直江翔太, 神﨑訓枝, 迫田晃弘, 田中裕史, 光延文裕, 山岡聖典

    第75回日本酸化ストレス学会学術集会抄録集   2022.5

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  • ラドン吸入は異なる作用で正常と関節リウマチマウスの免疫機能を調節する

    直江翔太, 片岡隆浩, 村上海斗, 雪峰諒平, 藤本有希, 神﨑訓枝, 迫田晃弘, 光延文裕, 山岡聖典

    第75回日本酸化ストレス学会学術集会抄録集   2022.5

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  • 焦電性結晶による発生X線の温度変化率効果

    花元克巳, 片岡隆浩, 山岡聖典

    第69回応用物理学会春季学術講演会予稿集   2022.3

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  • ラドン吸入によるマウス諸臓器中のレドックス状態の変化特性とDNA酸化損傷の抑制効果の濃度・吸入時間依存性の検討

    片岡隆浩, 首藤妃奈, 直江翔太, 矢野準喜, 神﨑訓枝, 迫田晃弘, 花元克巳, 光延文裕, 寺東宏明, 山岡聖典

    日本原子力学会 2022年春の年会講演抄録集   2022.3

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  • ラドン吸入による免疫調節機能の亢進効果の基礎検討

    直江翔太, 片岡隆浩, 村上海斗, 雪峰諒平, 藤本有希, 神﨑訓枝, 迫田晃弘, 光延文裕, 山岡聖典

    日本原子力学会2022年春の年会講演抄録集   2022.3

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  • 正常マウスとリウマチマウスではラドン吸入によるサイトカイン代謝に及ぼす影響は異なる

    直江翔太, 片岡隆浩, 村上海斗, 雪峰諒平, 藤本有希, 神﨑訓枝, 迫田晃弘, 光延文裕, 山岡聖典

    日本原子力学会中国・四国支部第15回研究発表会要旨集   2021.10

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  • ラドン吸入によるマウス諸臓器中のレドックス状態の変化特性とDNA酸化損傷の抑制効果の検討

    片岡隆浩, 首藤妃奈, 直江翔太, 矢野準喜, 神﨑訓枝, 迫田晃弘, 田中裕史, 花元克巳, 光延文裕, 寺東宏明, 山岡聖典

    日本原子力学会中国・四国支部第15回研究発表会要旨集   2021.10

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  • Radon inhalation decreases DNA damage induced by oxidative stress in mouse organs via the activation of antioxidative functions

    KATAOKA Takahiro, SHUTO Hina, NAOE Shota, YANO Junki, KANZAKI Norie, SAKODA Akihiro, TANAKA Hiroshi, HANAMOTO Katsumi, MITSUNOBU Fumihiro, TERATO Hiroaki, YAMAOKA Kiyonori

    日本放射線影響学会第64回大会講演要旨集   2021.9

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  • Dosimetry of radon progeny deposited on skin in air and thermal water

    SAKODA Akihiro, ISHIMORI Yuu, ISHIMORI Yuu, KANZAKI Norie, TANAKA Hiroshi, KATAOKA Takahiro, MITSUNOBU Fumihiro, YAMAOKA Kiyonori

    日本放射線影響学会第64回大会講演要旨集   2021.9

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  • Metabolomics Data Analysis in Mouse Organs Following Radon Inhalation Using Machine Learning

    Norie Kanzaki, Akihiro Sakoda, Takahiro Kataoka, Kiyonori Yamaoka

    日本放射線影響学会第64回大会講演要旨集   2021.9

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  • Basic study on the effects of radon inhalation on the cytokine metabolism in mouse blood

    Shota Naoe, Takahiro Kataoka, Yuki Fujimoto, Kaito Murakami, Ryohei Yukimine, Norie Kanzaki, Akihiro Sakoda, Fumihiro Mitsunobu, Kiyonori Yamaoka

    日本放射線影響学会第64回大会講演要旨集   2021.9

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  • ラドン吸入によるマウス血中サイトカインの変化特性に関する検討

    直江翔太, 片岡隆浩, 矢野準喜, 首藤妃奈, 神﨑訓枝, 迫田晃弘, 光延文裕, 山岡聖典

    第58回アイソトープ・放射線研究発表会要旨集   2021.7

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  • ラドン吸入によるマウス諸臓器中のDNA酸化損傷抑制の濃度依存性に関する検討

    増川祐伎, 片岡隆浩, 首藤妃奈, 直江翔太, 矢野準喜, 神﨑訓枝, 迫田晃弘, 田中裕史, 花元克巳, 光延文裕, 寺東宏明, 山岡聖典

    第58回アイソトープ・放射線研究発表会要旨集   2021.7

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  • ラドン吸入によるマウス臓器中のイオウ関連代謝物の変化-メタボローム解析結果の可視化-

    神﨑訓枝, 迫田晃弘, 片岡隆浩, 田中裕史, 山岡聖典

    第58回アイソトープ・放射線研究発表会要旨集   2021.7

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  • トロン吸入とアスコルビン酸投与による急性アルコール性マウス肝障害の抑制効果に関する検討

    西微香, 片岡隆浩, 石田毅, 直江翔太, 首藤妃奈, 矢野準喜, 神﨑訓枝, 迫田晃弘, 田中裕史, 光延文裕, 山岡聖典

    第58回アイソトープ・放射線研究発表会要旨集   2021.7

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  • ラドン吸入によるDNA酸化損傷の抑制効果に関する検討

    片岡隆浩, 神崎訓枝, 迫田晃弘, 首藤妃奈, 矢野準喜, 直江翔太, 田中裕史, 花元克巳, 寺東宏明, 光延文裕, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   74th   2021.5

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  • マウスの脳および肝臓中のラドン吸入による硫黄関連代謝物の変化

    神崎訓枝, 迫田晃弘, 片岡隆浩, 田中裕史, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   74th   2021.5

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  • Aging effects of the X-ray Energy and Intensity Produced by a Pyroelectric Crystal

    花元克巳, 片岡隆浩, 山岡聖典

    第68回応用物理学会春季学術講演会講演予稿集(CD-ROM)   2021.3

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  • Alteration of redox state following radon inhalation depends on the antioxidant capacity of organs

    T. Kataoka, N. Kanzaki, A. Sakoda, H. Shuto, J. Yano, S. Naoe, H. Tanaka, K. Hanamoto, H. Terato, F. Mitsunobu, K. Yamaoka

    Proceeding of 20th Biennial Meeting of Society for Free Radical Research – International   2021.3

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  • Low-dose irradiation reduces forced swim test-induced immobility and oxidative stress in mice

    Shota Naoe, Takahiro Kataoka, Hina Shuto, Junki Yano, Tsuyoshi Ishida, Tetsuya Nakada, Keiko Yamato, Katsumi Hanamoto, Takaharu Nomura, Kiyonori Yamaoka

    Proceeding of 20th Biennial Meeting of Society for Free Radical Research – International   2021.3

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  • 空気中または水中の皮膚表面に沈着したラドン子孫核種の線量計算

    迫田晃弘, 神﨑訓枝, 田中裕史, 石森有, 片岡隆浩, 光延文裕, 山岡聖典

    2020年度人形峠環境技術センターにおける研究・技術開発成果(JAEA-Review 2021)   ( 68 )   37 - 38   2021

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    DOI: 10.11484/jaea-review-2021-068

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  • ラドン吸入がマウス脳・肝臓に及ぼす酸化ストレスの変化特性

    片岡隆浩, 神崎訓枝, 迫田晃弘, 首藤妃奈, 矢野準喜, 直江翔太, 石田毅, 田中裕史, 花元克巳, 寺東宏明, 光延文裕, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   73rd   2020.10

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  • ラドン子孫核種の皮膚表面への沈着と被ばく線量

    136 - 136   2020.10

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  • Basic study on the effect of radon inhalation on edema of mouse limbs

    86 - 86   2020.10

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  • Evaluation of redox status in various organs of mice by radon inhalation

    87 - 87   2020.10

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  • Comprehensive Interpretation of Data on Biological Effects of Radon Inhalation by Metabolomics Using Machine Learning

    85 - 85   2020.10

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  • The differences in redox status in mice organs affect the activation of antioxidative functions by radon inhalation

    片岡隆浩, 神崎訓枝, 迫田晃弘, 首藤妃奈, 矢野準喜, 直江翔太, 石田毅, 田中裕史, 花元克巳, 寺東宏明, 光延文裕, 山岡聖典

    日本原子力学会2020年秋の大会予稿集   2020.9

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  • Activation of antioxidative functions by low-dose X-irradiation inhibits forced swim test induced immobility of mice

    首藤妃奈, 片岡隆浩, 矢野準喜, 直江翔太, 石田毅, 中田哲也, 大和恵子, 花元克巳, 野村崇治, 山岡聖典

    日本原子力学会2020年春の年会予稿集   2020.3

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  • Aging effects of the X-ray Energy and Intensity Produced by an LiTaO3 Single Crystal

    花元克巳, 片岡隆浩, 山岡聖典

    応用物理学会春季学術講演会講演予稿集   67th   2020.3

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  • Radon inhalation time dependent changes of hydrogen peroxide production in mice organs

    片岡隆浩, 神崎訓枝, 迫田晃弘, 首藤妃奈, 矢野準喜, 石田毅, 田中裕史, 花元克巳, 寺東宏明, 光延文裕, 山岡聖典

    日本原子力学会2020年春の年会予稿集   2020.3

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  • Inhibitory effects of prior or post low-dose X-irradiation on forced swim test induced oxidative stress in mouse brain and its differences

    86 - 86   2019.11

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  • Evaluation of hydrogen peroxide induced oxidative stress by radon inhalation in mouse organs

    117 - 117   2019.11

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  • Machine learning based metabolic analysis about the regulation of glutathione synthesis in mouse brain due to radon inhalation

    神崎 訓枝, 迫田 晃弘, 田中 裕史, 片岡 隆浩, 石田 毅, 山岡 聖典

    日本放射線影響学会第62回大会講演要旨集   85 - 85   2019.11

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  • ラドン吸入による抗酸化機能の亢進がマウス諸臓器中の過酸化水素産生に及ぼす作用

    片岡隆浩, 神崎訓枝, 迫田晃弘, 石田毅, 首藤妃奈, 矢野準喜, 田中裕史, 花元克巳, 寺東宏明, 光延文裕, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   13th   2019.9

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  • 低線量X線によるマウス強制水泳試験の無動時間と脳中の酸化ストレスの抑制効果に関する検討

    首藤妃奈, 片岡隆浩, 矢野準喜, 石田毅, 中田哲也, 大和恵子, 花元克巳, 野村崇治, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   13th   2019.9

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  • 岡山大学医学部放射線技術科学専攻学生の放射線の健康影響に関する知識・意識の基礎調査

    片岡隆浩, 矢野準喜, 首藤妃奈, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   13th   2019.9

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  • 低線量X線照射によるマウスのうつ病症状に及ぼす作用に関する基礎的検討

    片岡隆浩, 石田毅, 柚木勇人, 大和恵子, 花元克巳, 野村崇治, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   56th   2019.7

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  • ラドン水の皮脂成分への溶解度とその温度依存性に関する検討

    石田毅, 迫田晃弘, 片岡隆浩, 神崎訓枝, 田中裕史, 柚木勇人, 光延文裕, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   56th   2019.7

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  • 低線量X線照射がマウスの強制水泳に伴う無動時間に及ぼす影響に関する検討

    片岡隆浩, 石田毅, 柚木勇人, 大和恵子, 花元克巳, 野村崇治, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   72nd   2019.6

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  • LiTaO3単結晶による発生X線の結晶表面-ターゲット間距離依存性 II

    花元克巳, 片岡隆浩, 山岡聖典

    応用物理学会春季学術講演会講演予稿集   66th   2019.3

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  • 機械学習による低線量放射線の生体影響評価

    神崎訓枝, 迫田晃弘, 片岡隆浩, 山岡聖典

    CCSE Workshop   30th   2019

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  • 焦電性結晶によるX線発生装置の開発-X線発生とギャップ間との関係に関して-

    首藤妃奈, 花元克巳, 片岡隆浩, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   12th   2018.11

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  • 低線量X線照射とアスコルビン酸投与の併用によるマウス脳中の酸化ストレス緩和に関する基礎的検討

    柚木勇人, 片岡隆浩, 神崎訓枝, 神崎訓枝, 小橋佑介, 石田毅, 花元克巳, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   12th   2018.11

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  • X線照射によるマウス脳の酸化ストレス状態の変化特性に関する検討

    片岡 隆浩, 神崎 訓枝, 柚木 勇人, 小橋 佑介, 石田 毅, 花元 克巳, 山岡 聖典

    日本放射線影響学会第61回大会講演要旨集   78 - 78   2018.11

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  • ラドン水の皮膚への作用に関する検討-皮脂諸成分への溶解度とその温度依存性-

    石田毅, 迫田晃弘, 片岡隆浩, 神崎訓枝, 田中裕史, 柚木勇人, 石森有, 光延文裕, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   12   28 - 31   2018.11

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  • 曖昧な低線量放射線影響の評価に向けた機械学習によるビジュアライズ手法の提案

    神崎 訓枝, 迫田 晃弘, 片岡 隆浩, 山岡 聖典

    日本放射線影響学会第61回大会講演要旨集   91 - 91   2018.11

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  • ラドンの皮脂成分での溶解特性

    石田 毅, 迫田 晃弘, 片岡 隆浩, 神崎 訓枝, 田中 裕史, 小橋 佑介, 柚木 勇人, 石森 有, 光延 文裕, 山岡 聖典

    日本放射線影響学会第61回大会講演要旨集   79 - 79   2018.11

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  • ラドンとトロンの吸入によるマウス諸臓器中の酸化ストレス緩和効果に関する比較検討

    小橋佑介, 片岡隆浩, 神崎訓枝, 神崎訓枝, 迫田晃弘, 田中裕史, 石森有, 光延文裕, 石田毅, 柚木勇人, 山岡聖典

    日本原子力学会2018年秋の大会予稿集   2018.9

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  • ラドン水の皮膚に及ぼす影響の基礎的検討-皮脂への溶解度-

    石田毅, 迫田晃弘, 片岡隆浩, 神崎訓枝, 田中裕史, 小橋佑介, 柚木勇人, 石森有, 光延文裕, 山岡聖典

    日本原子力学会2018年秋の大会予稿集   2018.9

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  • ラドン吸入によるマウス腎障害の抑制効果に関する検討

    笹岡香織, 笹岡香織, 片岡隆浩, 神崎訓枝, 神崎訓枝, 小橋佑介, 迫田晃弘, 石森有, 山岡聖典

    日本原子力学会2018年秋の大会予稿集   2018.9

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  • X線照射がマウス脳に及ぼす酸化ストレスの評価

    片岡隆浩, 神崎訓枝, 笹岡香織, 小橋佑介, 柚木勇人, 石田毅, 花元克巳, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   55th   2018.7

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  • 酸化ストレス疾患に対するラドン吸入と関連薬剤投与の抑制効果の比較検討

    神崎訓枝, 片岡隆浩, 小橋佑介, 石田毅, 柚木勇人, 迫田晃弘, 石森有, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   55th   2018.7

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  • X線照射がマウス脳に及ぼす酸化ストレスの線量と経過時間依存性の検討

    片岡隆浩, 神崎訓枝, 笹岡香織, 小橋佑介, 柚木勇人, 石田毅, 花元克巳, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   71st   2018.5

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  • 機械学習による低線量放射線と関連薬剤の効能比較

    神崎訓枝, 片岡隆浩, 小橋佑介, 石田毅, 柚木勇人, 迫田晃弘, 石森有, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   71st   2018.5

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  • 低線量放射線がマウス脳に及ぼす酸化ストレスの検討

    片岡隆浩, 神崎訓枝, 笹岡香織, 小橋佑介, 柚木勇人, 石田毅, 花元克巳, 山岡聖典

    日本原子力学会2018年春の年会予稿集   2018.3

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  • LiTaO3単結晶による発生X線の結晶表面-ターゲット間距離依存性

    花元克巳, 片岡隆浩, 山岡聖典

    応用物理学会春季学術講演会講演予稿集   65th   2018.3

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  • ラドン療法新規適応症探索のための抗酸化機能などを指標にした機械学習によるデータ解析

    神崎 訓枝, 片岡 隆浩, 小橋 佑介, 石田 毅, 柚木 勇人, 迫田 晃弘, 石森 有, 山岡 聖典

    日本放射線影響学会第60回大会講演要旨集   112 - 112   2017.10

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  • ラドンとトロンの吸入による生物学的効果に関する比較検討 小動物用トロン吸入装置の試作と抗酸化機能の比較

    小橋 佑介, 片岡 隆浩, 神崎 訓枝, 迫田 晃弘, 田中 裕史, 石森 有, 光延 文裕, 山岡 聖典

    日本放射線影響学会第60回大会講演要旨集   112 - 112   2017.10

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  • ラドン吸入によるマウス脳中のSOD活性の増加の機構とその生物学的意義

    片岡 隆浩, 神崎 訓枝, 小橋 佑介, 柚木 勇人, 石田 毅, 迫田 晃弘, 石森 有, 山岡 聖典

    日本放射線影響学会第60回大会講演要旨集   165 - 165   2017.10

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  • 機械学習を用いた低線量放射線による疾患抑制効果に関するデータ解析

    神崎訓枝, 片岡隆浩, 小橋佑介, 柚木勇人, 石田毅, 迫田晃弘, 石森有, 山岡聖典

    日本原子力学会2017年秋の大会予稿集   2017.9

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  • 改良型自己組織化マップ法による文献データに基づく低線量放射線の健康影響の評価

    神崎訓枝, 片岡隆浩, 小橋佑介, 柚木勇人, 石田毅, 迫田晃弘, 石森有, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   11th   2017.9

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  • 放射線安全の観点からみたプレガバリンの副作用低減を考慮したラドン療法併用による費用対効果に関する検討

    麓有希, 片岡隆浩, 神崎訓枝, 山岡聖典

    安全工学研究発表会講演予稿集   50th   2017.9

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  • 小動物用トロン吸入装置の試作とこれを用いたラドンとトロンの吸入効果比較の基礎的検討

    小橋佑介, 片岡隆浩, 神崎訓枝, 迫田晃弘, 田中裕史, 石森有, 光延文裕, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   11th   2017.9

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  • ラドン吸入によるマウス脳におけるMn-SODの誘導合成機構の検討

    片岡隆浩, 神崎訓枝, 小橋佑介, 柚木勇人, 石田毅, 迫田晃弘, 石森有, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   11th   2017.9

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  • ラドン吸入によるマウス脳中のMn-SOD活性の増加に伴う疾患・老化の抑制の可能性

    片岡隆浩, 神崎訓枝, 小橋佑介, 柚木勇人, 石田毅, 迫田晃弘, 石森有, 山岡聖典

    日本原子力学会2017年秋の大会予稿集   2017.9

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  • 低線量放射線による疾患抑制の可能性に関する機械学習を用いた特徴抽出

    神崎訓枝, 片岡隆浩, 笹岡香織, 小橋佑介, 石田毅, 柚木勇人, 迫田晃弘, 石森有, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   54th   2017.7

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  • ラドンの吸入と飲泉の差異によるアルコール誘導マウス胃粘膜障害の抑制効果の比較検討

    片岡隆浩, 恵谷玲央, 恵谷玲央, 神崎訓枝, 迫田晃弘, 田中裕史, 石森有, 光延文裕, 田口勇仁, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   54th   2017.7

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  • ラドン吸入によるシスプラチン誘導腎障害の抑制に関するマウス系統差の比較検討

    笹岡香織, 片岡隆浩, 小橋佑介, 神崎訓枝, 迫田晃弘, 石森有, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   54th   2017.7

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  • 低線量放射線による疾患抑制効果と抗酸化機能の関連についての機械学習を用いた検討

    神崎訓枝, 片岡隆浩, 小橋佑介, 石田毅, 柚木勇人, 迫田晃弘, 石森有, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   70th   2017.6

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  • ラドンの吸入と飲泉によるアルコール誘導マウス胃粘膜障害の抑制作用の機序に関する比較検討

    片岡隆浩, 恵谷玲央, 恵谷玲央, 神崎訓枝, 迫田晃弘, 田中裕史, 石森有, 光延文裕, 田口勇仁, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   70th   2017.6

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  • ラドンの吸入または飲泉によるアルコール誘導マウス胃粘膜障害の抑制効果における抗酸化機能の関与

    片岡隆浩, 恵谷玲央, 神崎訓枝, 迫田晃弘, 田中裕史, 石森有, 光延文裕, 田口勇仁, 山岡聖典

    日本原子力学会2017年春の年会予稿集   2017.3

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  • 焦電性結晶によるX線イメージングの可能性

    花元克巳, 片岡隆浩, 山岡聖典

    応用物理学会春季学術講演会講演予稿集   64th   2017.3

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  • ラドン吸入によるシスプラチン誘導マウス腎障害の抑制に関する検討

    笹岡 香織, 片岡 隆浩, 恵谷 玲央, 神崎 訓枝, 迫田 晃弘, 石森 有, 山岡 聖典

    日本放射線影響学会第59回大会講演要旨集   13 - 13   2016.10

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  • 球面SOMを用いたラドン吸入とX線照射による抗酸化機能への影響の比較評価

    神崎 訓枝, 片岡 隆浩, 恵谷 玲央, 笹岡 香織, 小橋 佑介, 金川 明弘, 山岡 聖典

    日本放射線影響学会第59回大会講演要旨集   13 - 13   2016.10

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  • ラドン療法条件の最適化に関する基礎的検討

    片岡 隆浩, 恵谷 玲央, 神崎 訓枝, 笹岡 香織, 迫田 晃弘, 田中 裕史, 石森 有, 光延 文裕, 山岡 聖典

    日本放射線影響学会第59回大会講演要旨集   13 - 13   2016.10

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  • マウス酸化障害抑制に及ぼすラドン各種摂取方法の比較検討

    片岡隆浩, 恵谷玲央, 神崎訓枝, 笹岡香織, 迫田晃弘, 田中裕史, 小橋佑介, 石森有, 光延文裕, 山岡聖典

    日本原子力学会2016年秋の大会予稿集   2016.9

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  • ラドン吸入とプレガバリン投与の併用によるマウス神経障害性疼痛への抑制相加効果

    堀江駿介, 片岡隆浩, 恵谷玲央, 神崎訓枝, 笹岡香織, 小橋佑介, 花元克巳, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   10th   2016.9

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  • ラドン吸入とX線照射によるマウス肝臓への酸化ストレスの比較検討

    神崎訓枝, 片岡隆浩, 笹岡香織, 小橋佑介, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   10th   2016.9

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  • ラドン吸入とアスコルビン酸投与による一過性脳虚血に伴う神経細胞障害の抑制効果の比較検討

    片岡隆浩, 神崎訓枝, 笹岡香織, 小橋佑介, 花元克己, 田口勇仁, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   10th   2016.9

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  • アルコール誘導マウス胃粘膜障害へのラドンの吸入と飲泉による抑制効果の組織・病理学的比較検討

    石田毅, 片岡隆浩, 恵谷玲央, 神崎訓枝, 迫田晃弘, 田中裕史, 石森有, 光延文裕, 田口勇仁, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   10th   2016.9

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  • マウス肝機能に及ぼす低線量放射線とアルコールの作用に関する比較検討

    神崎訓枝, 片岡隆浩, 恵谷玲央, 笹岡香織, 小橋佑介, 山岡聖典

    日本原子力学会2016年秋の大会予稿集   2016.9

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  • 球面SOMを用いた低線量放射線と低用量アルコールによる酸化ストレスの比較検討

    神崎訓枝, 片岡隆浩, 恵谷玲央, 笹岡香織, 小橋佑介, 金川明弘, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   69th   2016.8

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  • 低線量放射線への適応応答による酸化障害の抑制に関する基礎的研究

    片岡隆浩, 田口勇仁, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   69th   2016.8

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  • ラドン吸入がシスプラチン誘導マウス腎障害に及ぼす効果

    笹岡香織, 片岡隆浩, 恵谷玲央, 神崎訓枝, 迫田晃弘, 石森有, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   53rd   2016.7

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  • ラドン吸入とプレガバリン投与の併用はマウス神経障害性疼痛に対し相加効果がある

    片岡隆浩, 堀江駿介, 恵谷玲央, 神崎訓枝, 笹岡香織, 小橋佑介, 花元克巳, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   53rd   2016.7

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  • 自己組織化マップを用いた低線量放射線によるマウス肝臓への酸化ストレスの評価

    神崎訓枝, 片岡隆浩, 恵谷玲央, 笹岡香織, 金川明弘, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   53rd   2016.7

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  • LiTaO3単結晶による発生X線の平均温度変化率依存性

    花元克巳, 片岡隆浩, 山岡聖典

    応用物理学会春季学術講演会講演予稿集   63rd   2016.3

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  • 自己組織化マップを用いたラドン吸入による微量酸化ストレスの各種評価

    神崎訓枝, 片岡隆浩, 恵谷玲央, 笹岡香織, 峯田英幸, 金川明弘, 山岡聖典

    日本原子力学会2016年春の年会予稿集   2016.3

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  • Animal Study on Biological Responses by Radon Inhalation Making Use of Waste Rock which Contains Feeble Activity of Uranium (2) Reviewed

    石森有, 迫田晃弘, 田中裕史, 光延文裕, 山岡聖典, 片岡隆浩, 恵谷玲央

    日本原子力研究開発機構JAEA-Research(Web)   2015 ( 024 )   1 - 41   2016.3

  • 一過性虚血に伴うスナネズミ脳細胞障害に対するラドン吸入と抗酸化ビタミン剤摂取による抑制効果の比較検討

    片岡隆浩, 恵谷玲央, 神崎訓枝, 笹岡香織, 小橋佑介, 田口勇仁, 山岡聖典

    日本原子力学会2016年春の年会予稿集   2016.3

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  • ラドン吸入がリポ多糖経鼻投与に伴う肺中の抗酸化物質に及ぼす効果

    中田哲也, 片岡隆浩, 恵谷玲央, 神崎訓枝, 迫田晃弘, 石森有, 田口勇仁, 山岡聖典

    日本放射線安全管理学会学術大会講演予稿集   14th   2015.12

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  • ラドン吸入またはアスコルビン酸投与によるスナネズミ一過性脳虚血に伴う細胞障害の抑制に関する検討

    片岡 隆浩, 恵谷 玲央, 神崎 訓枝, 笹岡 香織, 堀江 駿介, 小橋 佑介, 田口 勇仁, 山岡 聖典

    日本放射線影響学会ワークショップ講演論文集   98 - 99   2015.10

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  • ラドン温泉における吸入または飲泉による高尿酸血症の抑制効果の比較検討

    恵谷 玲央, 片岡 隆浩, 神崎 訓枝, 迫田 晃弘, 田中 裕史, 石森 有, 光延 文裕, 山岡 聖典

    日本放射線影響学会ワークショップ講演論文集   86 - 87   2015.10

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  • 自己組織化マップを用いたラドン吸入による肝臓への酸化ストレスの評価

    神崎 訓枝, 片岡 隆浩, 恵谷 玲央, 笹岡 香織, 金川 明弘, 山岡 聖典

    日本放射線影響学会ワークショップ講演論文集   88 - 89   2015.10

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  • ラドン温泉における高尿酸血症の抑制効果に関する検討

    恵谷玲央, 片岡隆浩, 神崎訓枝, 迫田晃弘, 田中裕史, 石森有, 光延文裕, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   9th   2015.9

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  • ラドン吸入によるSOD活性の増加がスナネズミ一過性脳虚血に伴う細胞障害抑制に有効に働く

    片岡隆浩, 恵谷玲央, 神崎訓枝, 笹岡香織, 田口勇仁, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   9th   2015.9

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  • ラドン吸入によるシスプラチン誘導マウス腎障害の緩和の可能性

    笹岡香織, 片岡隆浩, 恵谷玲央, 神崎訓枝, 迫田晃弘, 石森有, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   9th   2015.9

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  • 自己組織化マップによるラドン吸入とアルコール摂取の酸化ストレスの比較

    神崎訓枝, 片岡隆浩, 恵谷玲央, 笹岡香織, 金川明弘, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   9th   2015.9

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  • ラドン吸入によるSOD活性の増加作用に関する分子機序の検討

    片岡隆浩, 恵谷玲央, 神崎訓枝, 中田哲也, 迫田晃弘, 石森有, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   52nd   2015.7

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  • ラドン吸入によるXOD活性の減少は尿酸値の増加を抑制する

    恵谷玲央, 片岡隆浩, 神崎訓枝, 中田哲也, 迫田晃弘, 田中裕史, 石森有, 光延文裕, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   52nd   2015.7

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  • ラドン吸入による抗酸化機能の亢進は高尿酸血症の症状緩和に有効に働く

    恵谷玲央, 片岡隆浩, 神崎訓枝, 迫田晃弘, 田中裕史, 石森有, 光延文裕, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   68th   2015.6

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  • ラドン吸入によるマウス脳中SOD活性の増加とその機構に関する考察

    片岡隆浩, 恵谷玲央, 神崎訓枝, 小橋佑介, 迫田晃弘, 石森有, 光延文裕, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   68th   2015.6

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  • Study on inhibitory effects of radon inhalation on hyperuricemia in mice

    Reo Etani, Takahiro Kataoka, Norie kanzaki, Akihiro Sakoda, Yuu Ishimori, Takehito Taguchi, Kiyonori Yamaoka

    Proceeding of The 15th International Congress of Radiation Research & 日本放射線影響学会第58回大会   2015.5

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  • Measurements of radon concentration in mouse blood following radon inhalation

    Yuu Ishimori, Hiroshi Tanaka, Akihiro Sakoda, Takahiro Kataoka, Kiyonori Yamaoka, Fumihiro Mitsunobu

    Proceeding of The 15th International Congress of Radiation Research & 日本放射線影響学会第58回大会   2015.5

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  • Comparative study on oxidative stress effects induced by radon inhalation with alcohol administration in mouse liver

    Norie Kanzaki, Takahiro Kataoka, Reo Etani, Kaori Sasaoka, Shunsuke Horie, Kiyonori Yamaoka

    Proceeding of The 15th International Congress of Radiation Research & 日本放射線影響学会第58回大会   2015.5

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  • Study on response of antioxidant enzymes in mice organs to radon inhalation

    Takahiro Kataoka, Reo Etani, Norie Kanzaki, Tetsuya Nakada, Akihiro Sakoda, Yuu Ishimori, Kiyonori Yamaoka

    Proceeding of The 15th International Congress of Radiation Research & 日本放射線影響学会第58回大会   2015.5

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  • LiTaO3単結晶による発生X線の温度差に対する変化

    花元克巳, 片岡隆浩, 山岡聖典

    応用物理学会2015年春季学術講演会講演予稿集   62nd   2015.3

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  • ラドン含有の吸入と飲泉によるマウス1型糖尿病の抑制効果の比較検討

    片岡 隆浩, 西山 祐一, 迫田 晃弘, 恵谷 玲央, 神崎 訓枝, 田中 裕史, 石森 有, 光延 文裕, 山岡 聖典

    日本放射線影響学会第57回大会講演要旨集   159 - 159   2014.9

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  • ラドン吸入による抗酸化機能の亢進が一過性脳虚血に伴うスナネズミ細胞障害に及ぼす効果

    片岡 隆浩, 恵谷 玲央, 神崎 訓枝, 中田 哲也, 田口 勇仁, 山岡 聖典

    日本放射線影響学会第57回大会講演要旨集   159 - 159   2014.9

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  • ラドン吸入によるマウス腎障害の抑制効果における抗酸化機能の関与の検討

    恵谷 玲央, 片岡 隆浩, 西山 祐一, 迫田 晃弘, 神崎 訓枝, 田中 裕史, 石森 有, 光延 文裕, 田口 勇仁, 山岡 聖典

    日本放射線影響学会第57回大会講演要旨集   136 - 136   2014.9

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  • ラドン吸入によるSODの活性増加の濃度・吸入時間依存性およびその局在に関する検討

    片岡隆浩, 恵谷玲央, 神崎訓枝, 中田哲也, 迫田晃弘, 田中裕史, 石森有, 光延文裕, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   8th   2014.9

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  • ラドン温泉において糖尿病の抑制に吸入と飲泉はどちらが有効か

    山岡聖典, 片岡隆浩, 西山祐一, 西山祐一, 恵谷玲央, 神崎訓枝, 光延文裕, 石森有, 迫田晃弘, 田中裕史

    日本酸化ストレス学会学術集会抄録集   67th   2014.9

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  • ラドン吸入と抗酸化ビタミン投与の併用によるアルコール性マウス肝障害の抑制効果に関する検討

    恵谷玲央, 片岡隆浩, 西山祐一, 西山祐一, 高田裕司, 高田裕司, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   8th   2014.9

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  • 極微量放射性物質塗布によるマウス炎症性浮腫の抑制効果

    片岡隆浩, 高田裕司, 恵谷玲央, 西山祐一, 西山祐一, 川辺睦, 花元克己, 神崎訓枝, 中田哲也, 田口勇仁, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   67th   2014.9

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  • マウス腎臓におけるラドン吸入による抗酸化機能の亢進と関連疾患抑制の検討

    恵谷玲央, 片岡隆浩, 西山祐一, 西山祐一, 迫田晃弘, 神崎訓枝, 田中裕史, 石森有, 光延文裕, 田口勇仁, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   67th   2014.9

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  • スナネズミ一過性脳虚血に伴う神経細胞障害に対するラドン吸入による抑制効果

    片岡隆浩, 恵谷玲央, 高田裕司, 川辺睦, 田口勇仁, 山岡聖典

    第51回アイソトープ・放射線研究発表会要旨集   153 - 153   2014.7

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  • ラドン吸入によるマウス腎障害の抑制効果とその医療応用の可能性

    恵谷玲央, 片岡隆浩, 高田裕司, 西山祐一, 迫田晃弘, 石森有, 光延文裕, 田口勇仁, 山岡聖典

    第51回アイソトープ・放射線研究発表会要旨集   22 - 22   2014.7

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  • 低線量放射線の健康影響研究:ラドン吸入による一過性脳虚血に伴う細胞障害の抑制効果

    片岡隆浩, 恵谷玲央, 西山祐一, 高田裕司, 田口勇仁, 山岡聖典

    日本原子力学会2014年春の年会予稿集   2014.3

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  • トロン温浴で健康寿命をアップ Invited

    山岡聖典

    花巻トロン元気通信   2014

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  • ラドン吸入によるマウス炎症性腸疾患の症状緩和に関する検討

    西山 祐一, 片岡 隆浩, 恵谷 玲央, 大和 恵子, 高山 裕司, 田口 勇仁, 山岡 聖典

    日本放射線影響学会第56回大会講演要旨集   175 - 175   2013.10

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  • ラドン吸入によるマウス肝障害の抑制効果とその医療応用の可能性

    片岡 隆浩, 西山 祐一, 恵谷 玲央, 高田 裕司, 迫田 晃弘, 石森 有, 光延 文裕, 田口 勇仁, 山岡 聖典

    日本放射線影響学会第56回大会講演要旨集   145 - 145   2013.10

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  • ラドン雰囲気におけるマウスの臓器吸収線量の系統的検討

    迫田 晃弘, 石森 有, 田中 裕史, 山岡 聖典, 片岡 隆浩, 西山 祐一, 光延 文裕

    日本放射線影響学会第56回大会講演要旨集   188 - 188   2013.10

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  • マウスへのラドン吸入と抗酸化ビタミン投与による抗酸化作用の比較検討

    片岡隆浩, 西山祐一, 恵谷玲央, 高田裕司, 迫田晃弘, 石森有, 田口勇仁, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   7th   2013.9

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  • ラジウム・ラドン温泉広域連携による地域活性化:ラジウム・ラドン温泉の健康効果 Invited

    山岡聖典

    健康と温泉フォーラム   4 - 4   2013.9

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  • ラドン吸入によるマウス大腸炎の抑制効果に関する検討

    西山祐一, 片岡隆浩, 大和恵子, 大和恵子, 田口勇仁, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   50th   2013.7

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  • 極微量放射性クリームがマウス炎症性足浮腫に及ぼす効果に関する検討

    高田裕司, 片岡隆浩, 恵谷玲央, 西山祐一, 大和恵子, 大和恵子, 田口勇仁, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   50th   2013.7

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  • ラドン吸入と抗酸化ビタミン投与によるマウス肝障害の抑制の相乗効果に関する検討

    恵谷玲央, 片岡隆浩, 西山祐一, 大和恵子, 大和恵子, 高田裕司, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   50th   2013.7

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  • ラドン吸入によるマウス炎症性腸疾患の抑制効果に関する検討

    西山祐一, 片岡隆浩, 大和恵子, 大和恵子, 田口勇仁, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   66th   2013.6

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  • ラドン吸入試験におけるマウスの線量評価

    迫田晃弘, 石森有, 田中裕史, 山岡聖典, 片岡隆浩, 西山祐一, 光延文裕

    日本保健物理学会研究発表会講演要旨集   46th   2013.6

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  • PCXMCにおいて線量計算に影響を与える因子

    川辺睦, 花元克巳, 飯島順, 熊代正行, 熊代正行, 片岡隆浩, 山岡聖典

    日本保健物理学会研究発表会講演要旨集   46th   2013.6

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  • ラドン吸入によるCCl4誘導マウス肝障害の抑制効果とその医療応用の可能性

    片岡隆浩, 西山祐一, 恵谷玲央, 高田裕司, 豊田晃章, 迫田晃弘, 石森有, 光延文裕, 田口勇仁, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   66th   2013.6

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  • ラドン吸入による急性アルコール性マウス肝障害の抑制効果に関する検討

    豊田晃章, 片岡隆浩, 西山祐一, 田口勇仁, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   66th   2013.6

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  • 広範囲な気圧下でのLiTaO3単結晶による発生X線と放出電荷

    花元克巳, 川辺睦, 片岡隆浩, 山岡聖典

    応用物理学会2013年春季学術講演会講演予稿集   60th   2013.3

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  • Animal Study on Biological Responses by Radon Inhalation Making Use of Waste Rock Which Contains Feeble Activity of Uranium Reviewed

    石森有, 迫田晃弘, 田中裕史, 光延文裕, 山岡聖典, 片岡隆浩, 大和恵子, 西山祐一

    日本原子力研究開発機構JAEA-Research(Web)   2013 ( 005 )   1 - 60   2013.3

  • 焦電性結晶による小型X線源の開発-低気圧下での電子電流と発生X線-

    花元克巳, 川辺睦, 片岡隆浩, 山岡聖典

    日本放射線安全管理学会学術大会講演予稿集   11th   2012.12

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  • マウス肝臓・腎臓におけるラドン吸入による抗酸化機能亢進とビタミン作用との比較

    片岡 隆浩, 西山 祐一, 迫田 晃弘, 大和 恵子, 森井 佑至, 恵谷 玲央, 高田 裕司, 石森 有, 田口 勇仁, 山岡 聖典

    日本放射線影響学会第55回大会講演要旨集   162 - 162   2012.9

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  • ラドン吸入によるマウス神経障害性疼痛の予防と緩和の効果に関する検討

    大和 恵子, 片岡 隆浩, 西山 祐一, 花元 克巳, 川辺 睦, 田口 勇仁, 山岡 聖典

    日本放射線影響学会第55回大会講演要旨集   162 - 162   2012.9

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  • ラドン療法によるI型糖尿病の症状緩和に関する一考察

    西山 祐一, 片岡 隆浩, 迫田 晃弘, 大和 恵子, 田中 裕史, 石森 有, 光延 文裕, 田口 勇仁, 山岡 聖典

    日本放射線影響学会第55回大会講演要旨集   162 - 162   2012.9

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  • ラドン吸入によるI型糖尿病マウスの抑制効果に関する検討

    西山祐一, 片岡隆浩, 大和恵子, 迫田晃弘, 田中裕史, 石森有, 光延文裕, 田口勇仁, 山岡聖典

    第49回アイソトープ・放射線研究発表会要旨集   119 - 119   2012.7

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  • マウス肝障害に対するラドン吸入とビタミンC・E投与による各抗酸化作用の比較検討

    森井佑至, 片岡隆浩, 西山祐一, 迫田晃弘, 大和恵子, 恵谷玲央, 高田裕司, 石森有, 田口勇仁, 山岡聖典

    第49回アイソトープ・放射線研究発表会要旨集   118 ( 118 )   2012.7

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  • ラドン吸入による炎症性疼痛と神経障害性疼痛の緩和効果に関する検討

    大和恵子, 片岡隆浩, 西山祐一, 田口勇仁, 山岡聖典

    第49回アイソトープ・放射線研究発表会要旨集   120 - 120   2012.7

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  • 極微量ウラン子孫核種の吸入による抗酸化機能の亢進に関するビタミン投与との比較による定量化

    片岡隆浩, 西山祐一, 迫田晃弘, 大和恵子, 恵谷玲央, 高田裕司, 森井佑至, 石森有, 田口勇仁, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   65th   2012.6

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  • ラドン吸入によるストレプトゾトシン誘導マウス1型糖尿病の抑制効果に関する検討

    西山祐一, 片岡隆浩, 迫田晃弘, 田中裕史, 石森有, 田口勇仁, 光延文裕, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   65th   2012.6

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  • 広範囲な気圧下でのLiTaO3単結晶による発生X線

    花元克巳, 眞鍋政樹, 川辺睦, 片岡隆浩, 山岡聖典

    応用物理学会学術講演会講演予稿集   73rd   2012.3

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  • LiTaO3単結晶によるX線発生持続時間の気圧依存性

    花元克巳, 川辺睦, 迫田晃弘, 片岡隆浩, 岡田麻里, 山岡聖典

    応用物理学関係連合講演会講演予稿集   59th   2012.3

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  • 診断X線装置における設定管電流が入射線量に与える影響

    川辺睦, 花元克巳, 迫田晃弘, 三村秀文, 山田一孝, 岸本海織, 片岡隆浩, 飯島順, 熊代正行, 山岡聖典

    医学物理 Supplement   32 ( 1 )   2012

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  • ヒトと小動物におけるラドン及び子孫核種の吸入による吸収線量

    迫田 晃弘, 石森 有, 深尾 光佑, 片岡 隆浩, 花元 克巳, 川辺 睦, 田中 裕史, 光延 文裕, 山岡 聖典

    日本放射線影響学会第54回大会講演要旨集   132 - 132   2011.11

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  • 四塩化炭素誘導マウス臓器障害に対するラドンの事前と事後吸入の抑制効果の比較検討

    西山 祐一, 片岡 隆浩, 寺岡 准一, 迫田 晃弘, 大和 恵子, 石森 有, 山岡 聖典

    日本放射線影響学会第54回大会講演要旨集   112 - 112   2011.11

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  • マウスにおけるラドン子孫核種吸入による肺の線量評価

    深尾 光佑, 迫田 晃弘, 石森 有, 片岡 隆浩, 花元 克巳, 川辺 睦, 光延 文裕, 山岡 聖典

    日本放射線影響学会第54回大会講演要旨集   112 - 112   2011.11

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  • 焦電性結晶による低線量X線源の開発 発生電圧の定量的評価

    花元 克巳, 迫田 晃弘, 川辺 睦, 片岡 隆浩, 山岡 聖典

    日本放射線影響学会第54回大会講演要旨集   160 - 160   2011.11

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  • 四塩化炭素誘導マウス肝障害に対するラドンとアスコルビン酸の各抗酸化作用の比較検討

    寺岡 准一, 片岡 隆浩, 西山 祐一, 森井 佑至, 大和 恵子, 迫田 晃弘, 石森 有, 田口 勇仁, 山岡 聖典

    日本放射線影響学会第54回大会講演要旨集   115 - 115   2011.11

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  • ラドン吸入によるマウス炎症性疼痛の緩和効果に関する検討

    大和 恵子, 片岡 隆浩, 西山 祐一, 寺岡 准一, 森井 佑至, 田口 勇仁, 山岡 聖典

    日本放射線影響学会第54回大会講演要旨集   115 - 115   2011.11

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  • ラドン吸入によるカラゲニン誘導マウス炎症性足浮腫の抑制効果に関する検討

    片岡 隆浩, 寺岡 准一, 西山 祐一, 迫田 晃弘, 大和 恵子, 石森 有, 野村 崇治, 田口 勇仁, 山岡 聖典

    日本放射線影響学会第54回大会講演要旨集   114 - 114   2011.11

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  • PCXMCにおける管電流時間積に基づく線量計算の評価

    川辺睦, 花元克巳, 迫田晃弘, 片岡隆浩, 飯島順, 山岡聖典

    日本放射線安全管理学会学術大会講演予稿集   10th   2011.11

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  • ラドンおよび子孫核種の吸入による体内線量の計算-マウス,ラット,ヒトにおける違い-

    迫田晃弘, 石森有, 深尾光佑, 片岡隆浩, 田中裕史, 川辺睦, 花元克巳, 光延文裕, 山岡聖典

    日本保健物理学会研究発表会講演要旨集   44th   2011.10

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  • マウス体内における吸入ラドンの挙動に関する研究

    石森有, 迫田晃弘, 田中裕史, 片岡隆浩, 山岡聖典, 光延文裕

    日本保健物理学会研究発表会講演要旨集   44th   2011.10

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  • 獣医療における診療従事者被ばくの現状と対策

    川辺 睦, 山田 一孝, 岸本 海織, 花元 克巳, 山岡 聖典

    日本放射線技師会雑誌   58 ( 9 )   849 - 849   2011.9

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  • 低気圧下でのLiTaO3単結晶による放出電子と発生X線

    花元克巳, 冨永裕樹, 川辺睦, 迫田晃弘, 片岡隆浩, 岡田麻里, 山岡聖典

    応用物理学会学術講演会講演予稿集   72nd   2011.8

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  • ラドン吸入によるマウスの抗酸化機能亢進と疾患抑制効果に関する最近の研究動向

    片岡隆浩, 迫田晃弘, 迫田晃弘, 吉本雅章, 西山祐一, 大和恵子, 寺岡准一, 豊田晃章, 石森有, 田口勇仁, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   48th   2011.7

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  • ラドンガス吸入による肺線量の評価-ヒトと実験小動物間の比較-

    迫田晃弘, 石森有, 田中裕史, 片岡隆浩, 川辺睦, 花元克巳, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   48th   2011.7

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  • 低線量X線照射によるマウス浮腫の抑制効果に関する検討

    吉本雅章, 片岡隆浩, 田口勇仁, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   48th   2011.7

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  • ラドン吸入装置の開発とこれを用いたマウスカラゲニン誘導浮腫の抑制効果に関する検討

    片岡隆浩, 寺岡准一, 迫田晃弘, 迫田晃弘, 西山祐一, 大和恵子, 野村崇治, 石森有, 田口勇仁, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   64th   2011.7

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  • LiTaO3単結晶により発生するX線の気圧依存性

    花元克巳, 川辺睦, 迫田晃弘, 片岡隆浩, 岡田麻里, 山岡聖典

    応用物理学関係連合講演会講演予稿集   58th   2011.3

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  • 産業動物X線撮影における放射線管理

    川辺睦, 迫田晃弘, 花元克巳, 片岡隆浩, 山田一孝, 佐藤斉, 山岡聖典

    日本放射線安全管理学会学術第9回大会講演予稿集   43 - 43   2010.12

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  • 吸入ラドンガスに起因した線量の解析

    迫田晃弘, 石森有, 片岡隆浩, 川辺睦, 花元克巳, 山岡聖典

    日本放射線安全管理学会学術第9回大会講演予稿集   108 - 108   2010.12

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  • 岡山大学病院(三朝)におけるラドン療法用の温泉水中,および周辺空間中ラドン濃度の特性

    西山祐一, 迫田晃弘, 石森有, 片岡隆浩, 光延文裕, 山岡聖典

    日本放射線安全管理学会学術第9回大会講演予稿集   109 - 109   2010.12

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  • トロン温熱浴が加齢に伴う疾患に及ぼす影響に関する検討

    青山裕, 片岡隆浩, 中川慎也, 迫田晃弘, 石森有, 光延文裕, 山岡聖典

    日本放射線安全管理学会学術第9回大会講演予稿集   84 - 84   2010.12

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  • 焦電性結晶による小型X線源の開発-発生X線に対する気圧の影響-

    花元克巳, 川辺睦, 迫田晃弘, 片岡隆浩, 岡田麻里, 山岡聖典

    日本放射線安全管理学会学術第9回大会講演予稿集   53 - 53   2010.12

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  • 小動物用ラドン吸入装置の開発とその性能評価

    迫田 晃弘, 花元 克巳, 片岡 隆浩, 川辺 睦, 吉本 雅章, 豊田 晃章, 西山 祐一, 寺岡 准一, 深尾 光佑, 山岡 聖典

    日本放射線影響学会第53回大会講演要旨集   151 - 151   2010.10

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  • ラドン吸入に対するマウス臓器別感受性に関する検討

    片岡 隆浩, 迫田 晃弘, 石森 有, 豊田 晃章, 西山 祐一, 花元 克巳, 川辺 睦, 田中 裕史, 光延 文裕, 山岡 聖典

    日本放射線影響学会第53回大会講演要旨集   152 - 152   2010.10

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  • 焦電性結晶による低線量X線源の開発

    花元 克巳, 迫田 晃弘, 片岡 隆浩, 川辺 睦, 永松 知洋, 山岡 聖典

    日本放射線影響学会第53回大会講演要旨集   152 - 152   2010.10

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  • ラドン吸入による四塩化炭素誘導マウス腎障害の抑制に関する検討

    西山 祐一, 片岡 隆浩, 迫田 晃弘, 豊田 晃章, 寺岡 准一, 青山 裕, 花元 克巳, 川辺 睦, 田口 勇仁, 山岡 聖典

    日本放射線影響学会第53回大会講演要旨集   152 - 152   2010.10

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  • ラドン子孫核種の吸入線量評価に向けたマウス肺気道における粒子の沈着効率の解析

    迫田 晃弘, 深尾 光佑, 石森 有, 花元 克巳, 川辺 睦, 片岡 隆浩, 西山 祐一, 山岡 聖典

    日本放射線影響学会第53回大会講演要旨集   151 - 151   2010.10

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  • 吸入摂取されたラドンの体内動態-ヒトと実験小動物における検討-

    迫田晃弘, 石森有, 川辺睦, 片岡隆浩, 花元克巳, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   4th   2010.9

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  • 吸入ラドンの体内動態解析-ヒトと実験小動物間の比較-

    迫田晃弘, 石森有, 片岡隆浩, 川辺睦, 花元克巳, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   47th   130 - 130   2010.7

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  • ラドン吸入による抗酸化機能亢進のマウス臓器別感受性に関する検討

    片岡隆浩, 迫田晃弘, 石森有, 豊田晃章, 西山祐一, 田中裕史, 光延文裕, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   63rd   2010.6

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  • 中真空中におけるLiTaO3単結晶の電子・X線放出特性

    花元克巳, 川辺睦, 迫田晃弘, 片岡隆浩, 大場央子, 山岡聖典

    応用物理学会学術講演会講演予稿集   71st   2010.3

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  • 超低温下におけるイメージングプレートのガンマ線応答

    迫田晃弘, 石森有, 片岡隆浩, 花元克巳, 川辺睦, 田中裕史, 山岡聖典

    日本放射線安全管理学会学術大会講演予稿集   8th   2009.12

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  • 獣医療におけるエックス線撮影時の保定者被曝

    川辺睦, 花元克巳, 片岡隆浩, 迫田晃弘, 山岡聖典

    日本放射線安全管理学会学術大会講演予稿集   8th   2009.12

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  • 51Cr含有放射性固体廃棄物中の放射能レベルの解析と評価-クリアランス制度の導入に向けて-

    永松知洋, 永松知洋, 花房直志, 迫田晃弘, 小野俊朗, 山岡聖典

    日本放射線安全管理学会学術大会講演予稿集   8th   2009.12

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  • 焦電結晶による小型放射線源の開発-温度傾斜率による電流特性の検討-

    山本祐紀, 花元克巳, 迫田晃弘, 川辺睦, 片岡隆浩, 山岡聖典

    日本放射線影響学会第52回大会講演要旨集   2009.11

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  • ラドン吸入による四塩化炭素誘導マウス肝障害の抑制効果とその最適吸入条件の検討

    片岡 隆浩, 迫田 晃弘, 野村 崇治, 石森 有, 豊田 晃章, 西山 祐一, 吉本 雅章, 光延 文裕, 田口 勇仁, 山岡 聖典

    日本放射線影響学会第52回大会講演要旨集   129 - 129   2009.11

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  • 低線量X線照射によるマウス慢性アルコール障害の抑制効果の検討

    豊田 晃章, 片岡 隆浩, 西山 祐一, 吉本 雅章, 田口 勇仁, 山岡 聖典

    日本放射線影響学会第52回大会講演要旨集   129 - 129   2009.11

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  • トロン温泉の生活習慣病に及ぼす健康効果の基礎的検討

    中川 慎也, 片岡 隆浩, 迫田 晃弘, 石森 有, 吉田 昭, 山岡 聖典

    日本放射線影響学会第52回大会講演要旨集   128 - 128   2009.11

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  • 低線量X線照射による凍結マウス脳損傷の抑制効果の病理学的検討

    吉本 雅章, 片岡 隆浩, 中川 慎也, 豊田 晃章, 西山 祐一, 田口 勇仁, 山岡 聖典

    日本放射線影響学会第52回大会講演要旨集   128 - 128   2009.11

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  • 岩石における自然放射能分布の不均一性の検討

    迫田晃弘, 花元克巳, 石森有, 山本祐紀, 西山祐一, 山岡聖典

    日本放射線影響学会第52回大会講演要旨集   2009.11

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  • 焦電結晶による小型放射線源の開発-真空度と温度傾斜率に対するLiTaO3の電子放出特性-

    花元克巳, 山本祐紀, 迫田晃弘, 川辺睦, 片岡隆浩, 山岡聖典

    日本放射線影響学会第52回大会講演要旨集   2009.11

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    応用物理学会学術講演会講演予稿集   70th ( 2 )   2009.9

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  • 微量ラドン放出健康製品の諸特性とその生体的効果に関する基礎的検討

    中川慎也, 中川慎也, 青山裕, 片岡隆浩, 迫田晃弘, 吉本雅章, 石森有, 川辺睦, 花元克巳, 光延文裕, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   46th   117 - 117   2009.7

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    アイソトープ・放射線研究発表会要旨集   46th   116 - 116   2009.7

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    石森有, 光延文裕, 山岡聖典, 片岡隆浩, 迫田晃弘

    日本保健物理学会研究発表会講演要旨集   43rd   2009.6

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    日本保健物理学会研究発表会講演要旨集   43rd   2009.6

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  • 低線量X線照射およびラドン吸入による抗酸化機能の亢進と活性酸素由来諸症状の緩和効果に関する最近の研究成果

    片岡隆浩, 迫田晃弘, 中川慎也, 吉本雅章, 野村崇冶, 光延文裕, 田口勇仁, 山岡聖典

    日本酸化ストレス学会学術集会抄録集   62nd   2009.6

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    迫田晃弘, 花元克巳, 石森有, 山岡聖典

    日本原子力学会2009年春の年会予稿集   2009.3

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  • 遠赤外線を用いたマイルド加温療法による2型糖尿病改善効果

    藤井義徳, 上者郁夫, 黒田昌弘, 山岡聖典, 篠崎洋二, 宮木康成

    中四国放射線医療技術   ( 4 )   2009

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    日本放射線安全管理学会学術大会講演予稿集   7th   2008.12

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    日本放射線安全管理学会学術大会講演予稿集   7th   2008.12

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    日本放射線影響学会第51回大会講演要旨集   151 - 151   2008.11

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    日本放射線影響学会第51回大会講演要旨集   151 - 151   2008.11

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    日本放射線影響学会第51回大会講演要旨集   120 - 120   2008.11

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  • ラドン吸入がマウス急性アルコール性障害に及ぼす作用に関する基礎的検討

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    日本放射線影響学会第51回大会講演要旨集   120 - 120   2008.11

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  • 2型糖尿病に対する岩盤浴の効果(第2報)

    上者 郁夫, 藤井 義徳, 黒田 昌宏, 山岡 聖典, 下山 弘志, 篠崎 洋二, 宮木 康成

    日本補完代替医療学会学術集会抄録集   11回   95 - 95   2008.11

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  • 低線量事前照射によるマウス脳浮腫の抑制効果に関する基礎的検討

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    日本放射線影響学会第51回大会講演要旨集   120 - 120   2008.11

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  • モンテカルロシミュレーションによる単粒構造をした土壌の222Rn散逸率の算出

    迫田晃弘, 花元克巳, 石森有, 山岡聖典

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    2008年日本放射化学会年会・第52回放射化学討論会研究発表要旨集   9   128 - 128   2008.9

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    迫田 晃弘, 花元 克巳, 永松 知洋, 石森 有, 山岡 聖典

    日本放射線影響学会第50回大会講演要旨集   121 - 121   2007.11

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    日本放射線影響学会第50回大会講演要旨集   120 - 120   2007.11

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    日本放射線影響学会第50回大会講演要旨集   122 - 122   2007.11

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    日本放射線影響学会第50回大会講演要旨集   121 - 121   2007.11

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    日本放射線影響学会第50回大会講演要旨集   121 - 121   2007.11

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  • 2型糖尿病血糖値に対する岩盤浴の効果

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    日本補完代替医療学会学術集会抄録集   10回   2007.11

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  • 低線量照射によるマウス虚血-再灌流障害の抑制効果に関する病理観察的検討

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    日本放射線影響学会第50回大会講演要旨集   122 - 122   2007.11

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  • 低線量照射によるマウス足虚血-再灌流障害の抑制効果に関する検討

    片岡隆浩, 水口優子, 吉本雅章, 中川慎也, 青山裕, 迫田晃弘, 田口勇仁, 山岡聖典

    アイソトープ・放射線研究発表会要旨集   44th   79 - 79   2007.7

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  • 天然ラジウム鉱石から水中へのラドン溶出に及ぼす環境諸因子の影響

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  • 特集 医科学の湯トロン Invited

    山岡聖典

    ヘルスレーダー(健康新聞社)   174   2007.5

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  • ラドン温泉療法による抗酸化機能の亢進と生体内酸化傷害(適応症)の緩和に関する最近の研究例

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    過酸化脂質研究   30 ( 1 )   2006.10

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  • 天然放射性鉱石の含有化合物と溶出放射性核種の関係

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    日本放射線影響学会第49回大会講演要旨集   130 - 131   2006.9

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