Faculty Profiles - HIRASAWA Akira

Papers - HIRASAWA Akira

Division display 141 - 160 of about 403 ／ All the affair displays >>

遺伝性腫瘍領域の新たな潮流

AOKI DAISUKE

実験医学 34 ( 16 ) 2671 - 2674 2016.10

婦人科悪性腫瘍に脳梗塞を合併したTrousseau症候群5例の検討

AOKI DAISUKE

日本婦人科腫瘍学会雑誌 34 ( 4 ) 620 - 625 2016.10

Symptoms and effects of physical factors in Japanese middle-aged women Reviewed

Megumi Yokota, Kazuya Makita, Akira Hirasawa, Takashi Iwata, Daisuke Aoki

MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY 23 ( 9 ) 974 - 983 2016.9

Language：English Publishing type：Research paper (scientific journal) Publisher：LIPPINCOTT WILLIAMS & WILKINS

Objective:The aim of the study was to clarify the prevalence and severity rates of symptoms and investigate whether symptoms varied in relation to body mass index (BMI).Methods:The study group composed of 1,969 women, aged 40 to 60 years, who presented at our department from 1993 through 2014. The participation rate was 98%. The presence or absence of symptoms was evaluated by having the participants complete the Keio Questionnaire, a self-administered questionnaire. To allow the results to be compared according to ovarian function, serum levels of follicle-stimulating hormone and estradiol were measured. Participants were classified into three groups according to BMI: underweight, normal weight, and overweight. Symptoms were also compared among these subgroups.Results:The most common symptom was general fatigue. Vasomotor symptoms differed significantly between pre- and postmenopause status. When symptoms were analyzed according to BMI, the severity rates of the following symptoms were significantly higher in the overweight group than in the normal weight and underweight groups: hot flushes, sweats, joint pain, numbness, and incontinence. On the contrary, the underweight group had significantly higher severities of cold constitution, nervousness, and wrinkled skin than did the other groups. In addition, an increase in BMI was associated with an increased severity of vasomotor symptoms.Conclusions:The prevalence and severities of shoulder stiffness, considered a characteristic symptom in Japanese women, were high. Increased BMI was shown to be associated with a higher severity of vasomotor symptoms, joint pain, nervousness, and urinary symptoms.

DOI： 10.1097/GME.0000000000000660

Web of Science

researchmap

Symptoms and effects of physical factors in Japanese middle-aged women. International journal

Megumi Yokota, Kazuya Makita, Akira Hirasawa, Takashi Iwata, Daisuke Aoki

Menopause (New York, N.Y.) 23 ( 9 ) 974 - 83 2016.9

Language：English Publishing type：Research paper (scientific journal) Publisher：Lippincott Williams and Wilkins

OBJECTIVE: The aim of the study was to clarify the prevalence and severity rates of symptoms and investigate whether symptoms varied in relation to body mass index (BMI). METHODS: The study group composed of 1,969 women, aged 40 to 60 years, who presented at our department from 1993 through 2014. The participation rate was 98%. The presence or absence of symptoms was evaluated by having the participants complete the Keio Questionnaire, a self-administered questionnaire. To allow the results to be compared according to ovarian function, serum levels of follicle-stimulating hormone and estradiol were measured. Participants were classified into three groups according to BMI: underweight, normal weight, and overweight. Symptoms were also compared among these subgroups. RESULTS: The most common symptom was general fatigue. Vasomotor symptoms differed significantly between pre- and postmenopause status. When symptoms were analyzed according to BMI, the severity rates of the following symptoms were significantly higher in the overweight group than in the normal weight and underweight groups: hot flushes, sweats, joint pain, numbness, and incontinence. On the contrary, the underweight group had significantly higher severities of cold constitution, nervousness, and wrinkled skin than did the other groups. In addition, an increase in BMI was associated with an increased severity of vasomotor symptoms. CONCLUSIONS: The prevalence and severities of shoulder stiffness, considered a characteristic symptom in Japanese women, were high. Increased BMI was shown to be associated with a higher severity of vasomotor symptoms, joint pain, nervousness, and urinary symptoms.

DOI： 10.1097/GME.0000000000000660

Scopus

PubMed

researchmap

Retrospective Analysis on the Feasibility and Efficacy of Docetaxel-Cisplatin Therapy for Recurrent Endometrial Cancer. International journal

Tomomi Ninomiya, Wataru Yamagami, Nobuyuki Susumu, Takeshi Makabe, Kensuke Sakai, Michiko Wada, Aya Takigawa, Tatsuyuki Chiyoda, Hiroyuki Nomura, Fumio Kataoka, Akira Hirasawa, Kouji Banno, Daisuke Aoki

Anticancer research 36 ( 4 ) 1751 - 8 2016.4

Language：English Publishing type：Research paper (scientific journal) Publisher：INT INST ANTICANCER RESEARCH

AIM: There is poor evidence regarding effective treatment for recurrent endometrial cancer. We treated patients with recurrent endometrial cancer with docetaxel-cisplatin (DP) therapy as second-line or third-line chemotherapy. We aimed to evaluate the feasibility and efficacy of DP therapy for patients with recurrent endometrial cancer. PATIENT AND METHODS: We included 26 patients diagnosed with recurrent endometrial cancer, who underwent DP chemotherapy at our Institution. Docetaxel at 70 mg/m(2)and cisplatin at 60 mg/m(2)were administered by intravenous injection every 3 weeks. We retrospectively analyzed the clinicopathological factors associated with the response rate (RR) and prognosis. We also analyzed the adverse effects of DP therapy. RESULTS: Median follow-up was 33.8 months and the median number of therapy cycles was six. Grade 3 or 4 adverse effects included leukopenia (66%), neutropenia (81%), anemia (9%), diarrhea (12%), general fatigue (12%), liver dysfunction (4%), peripheral neuropathy (4%), and hyponatremia (4%). RR was 58% and the median progression-free survival (PFS) was 7.5 months. The group with a treatment-free interval of 6 months or more tended to have better PFS than that with less than 6 months (p=0.01). The group with a platinum-free interval of 6 months or more had significantly better PFS than that with less than 6 months (p=0.09). Although the history of taxane usage was not relevant to prognosis, a taxane-free interval of 12 months or more was associated with a tendency for better PFS (p=0.06). CONCLUSION: DP therapy was fully feasible and demonstrated efficacy for patients with recurrent endometrial cancer.

Web of Science

PubMed

researchmap

婦人科疾患における自覚症状としての「冷え」,疾患単位としての「冷え症」の合併頻度についての検討

WATANABE KENJI

日本産科婦人科学会雑誌 68 ( 2 ) 677 - 677 2016.2

遺伝性乳がん卵巣がんに対するリスク低減卵管卵巣摘出術と術後ヘルスケア

AOKI DAISUKE

更年期と加齢のヘルスケア 14 ( 2 ) 316 - 318 2016.2

Factors affecting pregnancy outcomes in young women treated with fertility-preserving therapy for well-differentiated endometrial cancer or atypical endometrial hyperplasia. Reviewed International journal

Osamu Inoue, Toshio Hamatani, Nobuyuki Susumu, Wataru Yamagami, Seiji Ogawa, Takashi Takemoto, Akira Hirasawa, Kouji Banno, Naoaki Kuji, Mamoru Tanaka, Daisuke Aoki

Reproductive biology and endocrinology : RB&E 14 ( 1 ) 2 - 2 2016.1

Language：English Publishing type：Research paper (scientific journal) Publisher：BIOMED CENTRAL LTD

BACKGROUND: Patients hoping to preserve their fertility receive conservative treatment with high-dose medroxyprogesterone acetate (MPA) for well-differentiated endometrioid adenocarcinoma (EC) or atypical endometrial hyperplasia (AEH) . Such treatment generally involves frequent intrauterine operations, including dilation and curettage (D&C) and endometrial biopsy (EMB), which could result in endometritis, endometrial thinning, or intrauterine adhesion. In turn, any of these outcomes could adversely affect implantation and pregnancy development. The current study thus aimed to identify factors that might affect pregnancy following conservative treatment by MPA. METHODS: We compared a pregnancy group (45 patients) with a non-pregnancy group (53 patients) of MPA-treated patients to evaluate the factors affecting clinical pregnancy establishment. We undertook a multivariate logistic regression analysis based on factors shown by univariate analysis to be significantly different between the groups. Univariate analysis identified number of D&C, endometrial thickness, duration of MPA administration, age of pregnancy permission (the age at which a patient was first allowed to attempt pregnancy after disappearance of the lesion), period of disappearance of lesions, and recurrence as independent variables. RESULTS: The odds ratios (95 % confidence interval) of multivariate analysis for disease recurrence, endometrial thickness during ovulation, and age of pregnancy permission were 0.283 (0.102-0.785), 1.677 (1.251-2.248), and 0.889 (0.792-0.998), respectively. There was no significant difference in the other independent variables between groups. CONCLUSIONS: We identified three factors considered to affect pregnancy establishment following conservative treatment with MPA: recurrence, endometrial thickness during ovulation, and the age of the pregnancy permission. Introduction of infertility treatment including assisted reproductive technology (ART) soon after achieving tumor disappearance by MPA would therefore be beneficial for patients with disease recurrence, thin endometrium, or a higher age of pregnancy permission.

DOI： 10.1186/s12958-015-0136-7

Web of Science

PubMed

researchmap

Characterization of the STK11 splicing variant as a normal splicing isomer in a patient with Peutz-Jeghers syndrome harboring genomic deletion of the STK11 gene. Reviewed International journal

Kenta Masuda, Yusuke Kobayashi, Tokuhiro Kimura, Kiyoko Umene, Kumiko Misu, Hiroyuki Nomura, Akira Hirasawa, Kouji Banno, Kenjiro Kosaki, Daisuke Aoki, Kokichi Sugano

Human genome variation 3 16002 - 16002 2016

Language：English Publishing type：Research paper (scientific journal)

We report a STK11 splicing variant comprising a 131-bp insertion that is derived from intron 1, which has previously been reported to possess potent pathogenicity. The same variant was detected in a Peutz-Jeghers syndrome patient harboring a genomic deletion in the vicinity of exon 1 of the STK11 gene, which indicated that this variant was derived from the wild-type allele. We also found the same variant in other normal subjects. This variant corresponds to the predicted transcript variant of STK11 (XM_011528209), which is derived from the genomic sequence of Chr19 (NT_011295.12). Therefore, we concluded that the splicing variant was not pathogenic.

DOI： 10.1038/hgv.2016.2

PubMed

researchmap

Profiling of Epithelial Ovarian Cancer as BRCAness Status with MLPA Method. Reviewed

Hirasawa A, Akahane T, Masuda K, Ninomiya T, Yamagami W, Nomura H, Kataoka F, Banno K, Susumu N, Aoki D

Curr Oncol 23 ( 3 ) e305 2016

バイオリソースを用いた研究基盤整備に関する国内外の動き Invited Reviewed

平沢晃, 青木大輔

産科と婦人科 83 ( 1 ) 13 - 19 2016

遺伝性腫瘍 Invited Reviewed

平沢晃, 山上亘, 青木大輔

産婦人科の実際 65 ( 6 ) 653 - 659 2016

遺伝性乳がん卵巣がん; 遺伝性腫瘍-実地臨床での対応を目指して Invited

平沢晃, 青木大輔

日本医師会雑誌 145 ( 4 ) 705 - 709 2016

卵巣・卵管の良性腫瘍・類腫瘍 Invited

日本女性医学学会編

女性医学ガイドブック思春期・性成熟期編2016年度版 151 - 154 2016

両側卵巣摘出術を施行した婦人科がんサバイバーのQOL向上を目指した疫学因子および遺伝因子の解析. Invited Reviewed

平沢晃

日本女性医学学会雑誌 24 ( 1 ) 48 - 52 2016

子宮体部・卵巣同時発生重複癌40症例の臨床病理学的検討. Reviewed

小笠原淳, 小林佑介, 野村弘行, 山上亘, 片岡史夫, 平沢晃, 冨永英一郎, 鈴木淳, 阪埜浩司, 進伸幸, 田中守, 青木大輔

東京産科婦人科学会会誌 65 ( 3 ) 436 - 439 2016

[Free fatty acid receptors as therapeutic targets for metabolic disorders].

Akira Hirasawa, Masato Takeuchi, Ryouhei Shirai, Zao Chen, Shota Ishii, Keiko Iida

Nihon yakurigaku zasshi. Folia pharmacologica Japonica 146 ( 6 ) 296 - 301 2015.12

EVALUATION OF PRE- OR INTRA-OPERATIVE DIAGNOSTIC METHOD FOR UTERINE CARCINOSARCOMA

T. Makabe, W. Yamagami, N. Susumu, K. Sakai, T. Yoshihama, N. Iwasa, N. Nakadaira, S. Hashimoto, T. Ninomiya, M. Wada, A. Takigawa, H. Nomura, F. Kataoka, A. Hirasawa, K. Banno, D. Aoki

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 25 ( 9 ) 1107 - 1107 2015.10

子宮体がんの予防とヘルスケア

AOKI DAISUKE

産婦人科の実際女性ヘルスケア集中講義！ 61 ( 10月臨時増刊号 ) 399 - 408 2015.10

若年子宮体癌、および子宮内膜異型増殖症に対して妊孕性温存治療を施行することによる精神的影響

横田めぐみ, 山上亘, 坂井健良, 真壁健, 二宮委美, 和田美智子, 野村弘行, 片岡史夫, 平澤晃, 牧田和也, 阪埜浩司, 進伸幸, 青木大輔, 白波瀬丈一郎

日本女性医学学会雑誌 23 ( Suppl. ) 140 - 140 2015.10

　 PREV - NEXT 　

< HIRASAWA Akira >

Papers - HIRASAWA Akira