Faculty Profiles - IWAMURO Masaya

Papers - IWAMURO Masaya

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肝移植後も消化管出血を繰り返した先天性胆道閉鎖症の一例

石田正也, 川野誠司, 岡本雄貴, 大林由佳, 濱田健太, 馬場雄己, 榮浩行, 後藤田達洋, 安部真, 井口俊博, 神崎洋光, 岩室雅也, 平岡佐規子, 岡田裕之, 河原祥朗, 楳田祐三, 八木孝仁

日本消化器病学会中国支部例会・日本消化器内視鏡学会中国支部例会プログラム・抄録集 110回・121回 157 - 157 2018.12

【知っておきたい十二指腸病変】十二指腸非乳頭部隆起性病変十二指腸リンパ腫の診断

岡田裕之, 田中健大, 岩室雅也, 神崎洋光, 川野誠司, 河原祥朗, 高田尚良, 吉野正

胃と腸 53 ( 12 ) 1587 - 1594 2018.11

Two Cases of White Globe Appearance in Autoimmune Atrophic Gastritis. Reviewed International journal

Masaya Iwamuro, Takehiro Tanaka, Hiromitsu Kanzaki, Seiji Kawano, Yoshiro Kawahara, Hiroyuki Okada

Case reports in gastrointestinal medicine 2018 7091520 - 7091520 2018.10

Language：English

In this report, we described two patients with white globe appearance in autoimmune atrophic gastritis. Endoscopy revealed multiple white substances in the stomach in both cases. Biopsied specimens from the lesions contained dilated glands and showed a decrease in parietal cells. Intraglandular necrotic debris and carcinoma were absent. These results confirmed that white globe appearance can be observed in autoimmune atrophic gastritis. Moreover, microscopic features for white globe appearance observed in these cases were different from those reported previously in gastric cancer lesions and were similar to those observed for noncancerous stomach.

DOI： 10.1155/2018/7091520

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Dipeptide γ-secretase inhibitor treatment enhances the anti-tumor effects of cisplatin against gastric cancer by suppressing cancer stem cell properties. Reviewed International journal

Ryo Kato, Masaya Iwamuro, Hidenori Shiraha, Shigeru Horiguchi, Emi Tanaka, Ken Matsumoto, Atsushi Ohyama, Hiroaki Sawahara, Teruya Nagahara, Daisuke Uchida, Koichiro Tsutsumi, Hiroyuki Okada

Oncology letters 16 ( 4 ) 5426 - 5432 2018.10

Language：English Publishing type：Research paper (scientific journal)

The γ-secretase inhibitor blocks Notch activity by preventing its cleavage at the cell surface. In the present study, the effect of the γ-secretase inhibitor on the viability of gastric cancer cells when administered in combination with cisplatin was investigated, with particular focus on CD44highLgr-5high cancer cells. The four gastric cancer cell lines, MKN45, MKN74, SC-6-JCK and SH-10-TC, were used for the experiments. In the MTT assay, treatment with 25 µM dipeptide γ-secretase inhibitor (DAPT) alone did not affect cell proliferation in any of the four cell lines. Gastric cancer cells subjected to combination treatment with DAPT and cisplatin exhibited decreased viability when compared with those treated with cisplatin alone. Flow cytometry was performed to evaluate the expression of cluster of differentiation (CD)-44 and leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr-5), two cancer stem cell markers in gastric cancers. Treatment with cisplatin alone significantly increased the proportion of CD44highLgr-5high cells. However, the addition of DAPT to cisplatin reduced the CD44highLgr-5high fraction, suggesting that DAPT reduced the number of gastric cancer cells. In conclusion, the present study demonstrated the synergistic effects of DAPT in combination with cisplatin by decreasing the survival of gastric cancer cells. In addition, combination treatment with DAPT reduced the number of CD44highLgr-5high cells, which are thought to exhibit cancer stem cell properties. These results highlight the therapeutic potential of DAPT in gastric cancer treatment.

DOI： 10.3892/ol.2018.9301

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胃・十二指腸へのランタン沈着症の特徴

岩室雅也, 神崎洋光, 川野誠司, 河原祥朗, 田中健大, 岡田裕之

Gastroenterological Endoscopy 60 ( Suppl.2 ) 2140 - 2140 2018.10

Pseudolipomatosis of the Colon and Cecum Followed by Pneumatosis Intestinalis. Reviewed

Masaya Iwamuro, Takehiro Tanaka, Tomoko Kawabata, Yuusaku Sugihara, Keita Harada, Sakiko Hiraoka, Hiroyuki Okada

Internal medicine (Tokyo, Japan) 57 ( 17 ) 2501 - 2504 2018.9

Language：English Publishing type：Research paper (scientific journal)

A 74-year-old Japanese woman was diagnosed with pseudolipomatosis of the cecum and ascending colon. Colonoscopy was performed, which revealed the presence of slightly elevated white lesions, while a magnifying observation showed microbubbles within the mucosa. A month after colonoscopy, the patient was diagnosed with pneumatosis intestinalis. Although the exact pathogenesis is unclear, pneumatosis intestinalis may arise secondary to pseudolipomatosis. This case also indicates that a magnifying observation during colonoscopy may aid in the diagnosis of pseudolipomatosis of the large intestine, since it shows microbubbles within the mucosa, which may be a distinctive feature reflecting the pathology of this disease.

DOI： 10.2169/internalmedicine.0730-17

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Diffuse redness in linked color imaging is useful for diagnosing current Helicobacter pylori infection in the stomach. Reviewed

Masaya Iwamuro, Hiroyuki Sakae, Hiromitsu Kanzaki, Hiroyuki Okada

Journal of general and family medicine 19 ( 5 ) 176 - 177 2018.9

Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

Esophagogastroduodenoscopic examination shows diffuse redness of the mucosa of the gastric body, which can be identified as a deep reddish color. The present case underscores the importance of diffuse redness as a key endoscopic feature that enables prompt diagnosis of current Helicobacter pylori infection.

DOI： 10.1002/jgf2.195

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All carbonated beverages effectively dissolve phytobezoars. Reviewed

Iwamuro M, Yamauchi K, Shiraha H, Okada H

Clinics and research in hepatology and gastroenterology 42 ( 4 ) e66 - e67 2018.9

Enterovaginal and colovesical fistulas as late complications of pelvic radiotherapy.

Masaya Iwamuro, Kou Hasegawa, Yoshihisa Hanayama, Hitomi Kataoka, Takehiro Tanaka, Yoshitaka Kondo, Fumio Otsuka

Journal of general and family medicine 19 ( 5 ) 166 - 169 2018.9

Language：English

A 72-year-old Japanese woman presented with a fever, diarrhea, intermittent spotting, and constant fluid discharge from the vagina. Imaging studies revealed an enterovaginal fistula. She underwent radical hysterectomy and radiotherapy 35 years previously. She also had a surgical history of nephrostomy, nephrectomy, ileoascending anastomosis, and colostomy. As bleeding from the enterovaginal fistula was uncontrollable, ileocecal resection was performed. However, a colovesical fistula with urinary tract infection occurred 3 months later. The present case indicates that fistula formation occurs and causes various symptoms in patients who underwent postpelvic radiotherapy, particularly in those with prior surgeries in the irradiated field.

DOI： 10.1002/jgf2.184

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Primary Localized Esophageal Mucosa-associated Lymphoid Tissue Lymphoma Treated by Endoscopic Submucosal Dissection.

Sayo Kobayashi, Masaya Iwamuro, Kenji Nishida, Takehiro Tanaka, Seiji Kawano, Yoshiro Kawahara, Tadashi Yoshino, Hiroyuki Okada

Internal medicine (Tokyo, Japan) 57 ( 16 ) 2347 - 2352 2018.8

Language：English Publishing type：Research paper (scientific journal)

A 69-year-old Japanese woman presented to our hospital for the further investigation of an esophageal subepithelial tumor. A diagnosis of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) was made by an endoscopic biopsy. The patient had no involvement other than the esophagus. The tumor was resected using endoscopic submucosal dissection. Lymphoma recurrence has not been documented in the 57 months since resection. This case suggests that although a detailed preoperative evaluation is required to determine the extent of tumor, endoscopic resection may be an option for the long-term disease control of MALT lymphoma of the esophagus.

DOI： 10.2169/internalmedicine.0487-17

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Lanthanum deposition corresponds to white lesions in the stomach Reviewed

Masaya Iwamuro, Haruo Urata, Takehiro Tanaka, Seiji Kawano, Yoshiro Kawahara, Katsuhiko Kimoto, Hiroyuki Okada

Pathology Research and Practice 214 ( 7 ) 934 - 939 2018.7

Manifestation of Central Diabetes Insipidus in a Patient with Thyroid Storm.

Akiko Nakamichi, Kazuki Ocho, Kosuke Oka, Miho Yasuda, Kou Hasegawa, Masaya Iwamuro, Mikako Obika, Kammei Rai, Fumio Otsuka

Internal medicine (Tokyo, Japan) 57 ( 13 ) 1939 - 1942 2018.7

Language：English Publishing type：Research paper (scientific journal)

We herein report a case of central diabetes insipidus complicated with thyroid storm. A middle-aged woman who was receiving treatment for Graves' disease suddenly complained of polydipsia, polyuria and general fatigue. Laboratory tests showed hyperthyroidism, hypernatremia, hypoosmolar urine and a decreased plasma vasopressin level. The occurrence of central diabetes insipidus with hyperthyroidism was revealed on the basis of pituitary magnetic resonance imaging, a water deprivation test and a desmopressin test. The clinical co-existence of diabetes insipidus and hyperthyroidism is very rare; however, the complication should be considered when hypernatremia and/or dehydration progress in patients with Graves's disease as a common autoimmune-related etiology.

DOI： 10.2169/internalmedicine.0063-17

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巨大肝嚢胞により複数の臓器障害を来した1例

長尾聡子, 岩室雅也, 灘隆宏, 戸川雄, 頼冠名, 小比賀美香子, 白羽英則, 大塚文男

日本病院総合診療医学会雑誌 14 ( 4 ) 441 - 441 2018.7

Severe Gastritis after Administration of Nivolumab and Ipilimumab

Yoshito Nishimura, Miho Yasuda, Kazuki Ocho, Masaya Iwamuro, Osamu Yamasaki, Takehiro Tanaka, Fumio Otsuka

Case Reports in Oncology 11 ( 2 ) 549 - 556 2018.5

Bleeding in patients who underwent scheduled second-look endoscopy 5 days after endoscopic submucosal dissection for gastric lesions Reviewed

Koichi Izumikawa, Masaya Iwamuro, Tomoki Inaba, Shigenao Ishikawa, Kenji Kuwaki, Ichiro Sakakihara, Kumiko Yamamoto, Sakuma Takahashi, Shigetomi Tanaka, Masaki Wato, Hiroyuki Okada

BMC Gastroenterology 18 ( 1 ) 2018.4

Evaluation of the Upper Gastrointestinal Tract in Ulcerative Colitis Patients. Reviewed

Ryo Kato, Masaya Iwamuro, Sakiko Hiraoka, Shiho Takashima, Toshihiro Inokuchi, Masahiro Takahara, Yoshitaka Kondo, Takehiro Tanaka, Hiroyuki Okada

Acta medica Okayama 72 ( 2 ) 105 - 113 2018.4

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

To analyze the clinical characteristics of patients with ulcerative colitis who have upper gastrointestinal lesions, we retrospectively reviewed the data of 216 patients with ulcerative colitis who underwent esophagogastroduodenoscopy at our institute in April 2008-March 2016. We investigated the endoscopic features and compared the clinical characteristics between the patients with and without upper gastrointestinal lesions. Forty-two patients (19.4%) had upper gastrointestinal lesions, including multiple erosions (n=18), bamboo joint-like appearance (n=17), mucosa with white spots (n=4), friable mucosa (n=2), ulcer (n=1), and purulent deposits within the mucosa (n=1) in the stomach and/or duodenum. Compared to the patients without upper gastrointestinal lesions, those with upper gastrointestinal lesions showed significantly more frequent extraintestinal manifestations (19.0% vs. 8.0%, p<0.05) and a significant history of colectomy (33.3% vs. 12.1%, p<0.01). There were no significant differences with regard to the sex ratio, age at esophagogastroduodenoscopy, gastrointestinal symptoms, time since the diagnosis of ulcerative colitis, type of colitis at the initial diagnosis of ulcerative colitis, or gastric atrophy between the groups. In conclusion, gastroduodenal lesions were identified in 19.4% of the patients with ulcerative colitis. Esophagogastroduodenoscopy is particularly recommended for ulcerative colitis patients who show extraintestinal manifestations and for those who have undergone a colectomy.

DOI： 10.18926/AMO/55850

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On going OGIBに対する安全な緊急ダブルバルーン内視鏡止血術成功への取り組み

川野誠司, 岡本雄貴, 大林由佳, 榮浩行, 安部真, 後藤田達洋, 河野吉泰, 井口俊博, 神崎洋光, 岩室雅也, 河原祥朗, 岡田裕之

Gastroenterological Endoscopy 60 ( Suppl.1 ) 686 - 686 2018.4

先端巨大症患者における大腸内視鏡検査時の盲腸到達時間に関する検討

大塚文男, 岩室雅也, 安田美帆, 長谷川功, 藤澤諭, 越智可奈子

日本内分泌学会雑誌 94 ( 1 ) 325 - 325 2018.4

超高齢者の早期胃癌に対するESDの安全性と有効性に関する検討

後藤田達洋, 川野誠司, 岡本雄貴, 馬場雄己, 大林由佳, 安部真, 河野吉泰, 神崎洋光, 岩室雅也, 田中健大, 河原祥朗, 岡田裕之

日本高齢消化器病学会誌 20 ( 2 ) 57 - 63 2018.3

食道顆粒細胞腫と食道平滑筋腫の診断における超音波内視鏡検査の有用性

岩室雅也, 田中健大, 神崎洋光, 川野誠司, 河原祥朗, 岡田裕之

日本消化器病学会雑誌 115 ( 臨増総会 ) A322 - A322 2018.3

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