Faculty Profiles - IWAMURO Masaya

Papers - IWAMURO Masaya

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男女別に見たHelicobacter pylori除菌前後での組織学的胃炎の変化

榮浩行, 岡上昇太郎, 大林由佳, 神崎洋光, 岩室雅也, 川野誠司, 河原祥朗, 田中健大, 岡田裕之

日本高齢消化器病学会誌 22 ( 1 ) 136 - 136 2019.7

A Huge Liver Cyst Manifesting Dyspnea and Edema. Reviewed

Satoko Nagao, Masaya Iwamuro, Hidenori Shiraha, Fumio Otsuka

Internal medicine (Tokyo, Japan) 58 ( 12 ) 1811 - 1812 2019.6

White globe appearance in gastric high-grade dysplasia. Reviewed International journal

Masaya Iwamuro, Hiroyuki Sakae, Takehiro Tanaka, Hiroyuki Okada

Gastrointestinal endoscopy 89 ( 6 ) 1254 - 1255 2019.6

葛西手術後にも消化管出血を繰り返した先天性胆道閉鎖症術後の一例

石田正也, 川野誠司, 岡本雄貴, 大林由佳, 濱田健太, 馬場雄己, 榮浩行, 後藤田達洋, 安部真, 井口俊博, 神崎洋光, 岩室雅也, 平岡佐規子, 岡田裕之, 河原祥朗, 楳田祐三, 八木孝仁

日本消化器病学会四国支部例会プログラム・抄録集 111回 70 - 70 2019.6

Anterior Cutaneous Nerve Entrapment Syndrome Possibly Triggered by Oral Contraceptives.

Daisuke Omura, Mikako Obika, Masaya Iwamuro, Satoko Nagao, Takahiro Nada, Takashi Matsuzaki, Yoshitaka Kondo, Fumio Otsuka

Internal medicine (Tokyo, Japan) 58 ( 10 ) 1507 - 1509 2019.5

Language：English Publishing type：Research paper (scientific journal)

We herein report a teenage girl who had been taking oral contraceptive pills for three months and complained of left lower abdominal pain that had continued for two months. A physical examination indicated anterior cutaneous nerve entrapment syndrome (ACNES), although no abnormality was found in various biochemical and imaging examinations. The pain was only transiently ameliorated by trigger-point injection, and neurectomy surgery was eventually effective. Sex steroids can be involved in the progress of local tissue edema causing ACNES. ACNES should be considered in cases of abdominal pain in patients taking oral contraceptives.

DOI： 10.2169/internalmedicine.1361-18

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A Bezoar Composed of Bilirubin Calcium, Calcium Carbonate, and Fatty Acid Calcium. Reviewed International journal

Masaya Iwamuro, Haruo Urata, Shoichiro Hirata, Toru Ueki, Tetsuro Hanabata, Sho Takeda, Akira Teraoka, Hiroyuki Okada

Case reports in gastrointestinal medicine 2019 5742672 - 5742672 2019.5

Language：English

A 68-year-old Japanese man was diagnosed with bezoar in the stomach, which was endoscopically retrieved. The bezoar was composed of bilirubin calcium, calcium carbonate, and fatty acid calcium. Due to the presence of bilirubin calcium in the bezoar, we performed imaging studies of the bile duct; gallstones and common bile duct stones were identified. Although bezoar with components similar to bile is infrequently encountered, our findings suggest that a bezoar originating from bile should be considered among the differential diagnoses in patients without a recent consumption history of persimmons who demonstrate a mass in the digestive tract. This case highlights the importance of component analysis of gastric bezoars because its findings may alter the treatment plan.

DOI： 10.1155/2019/5742672

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A multicenter observational study on the clinicopathological features of gastric cancer in young patients.

Yoshiyasu Kono, Hiromitsu Kanzaki, Takao Tsuzuki, Masahiro Takatani, Junichirou Nasu, Daisuke Kawai, Ryuta Takenaka, Takehiro Tanaka, Masaya Iwamuro, Seiji Kawano, Yoshiro Kawahara, Toshiyoshi Fujiwara, Hiroyuki Okada

Journal of gastroenterology 54 ( 5 ) 419 - 426 2019.5

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The details of gastric cancer in young patients remain unclear because of the low prevalence of the disease. This study aimed to clarify the clinicopathological features and prognosis of gastric cancer in young patients. METHODS: From January 2007 to January 2016, patients in their 20s and 30s who were diagnosed with primary gastric cancer at 4 hospitals were enrolled. Their clinical characteristics and prognosis were evaluated. RESULTS: The total number of patients was 72. The median age was 36 years, and the ratio of males to females was 1:1. The dominant histological type was undifferentiated type (66/72, 92%). Helicobacter pylori (H. pylori) was positive in 81% (54/67). Although there were some asymptomatic patients in stages I-III, all stage IV patients had some clinical symptoms at the diagnosis. The percentage of stage IV was significantly higher in patients in their 20s than in those in their 30s (75% vs. 25%, P < 0.001). The Kaplan-Meier method showed that the overall survival of patients in their 20s was significantly lower than that of patients in their 30s (P = 0.037). CONCLUSIONS: A high rate of H. pylori infection was revealed in young gastric cancer patients. The patients in their 20s had a worse prognosis than those in their 30s. We should consider examining the H. pylori infection status for young patients as well as older patients to identify high-risk populations.

DOI： 10.1007/s00535-018-1525-4

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Clinicopathological Features and Outcomes of Endoscopic Submucosal Dissection for Superficial Cancer of the Pharynx.

Makoto Abe, Masaya Iwamuro, Yoshiro Kawahara, Hiromitsu Kanzaki, Seiji Kawano, Takehiro Tanaka, Munechika Tsumura, Takuma Makino, Yohei Noda, Hidenori Marunaka, Kazunori Nishizaki, Hiroyuki Okada

Acta medica Okayama 73 ( 2 ) 109 - 115 2019.4

Language：English Publishing type：Research paper (scientific journal)

The efficacy and safety of endoscopic submucosal dissection (ESD) for superficial cancer of the pharynx are still unclear. To identify clinicopathological features of superficial pharyngeal cancer, and the efficacy and safety of ESD, we retrospectively assessed 70 pharyngeal cancers in 59 patients who underwent ESD. Of these patients, 61.0% and 50.8% had a history of esophageal cancer and head and neck cancer, respectively. The median tumor size was 15 mm, and 75.7% of the lesions were located at the piriform sinus. The en bloc resection rate was 94.9%. Treatment-related adverse events occurred in 8 cases, but there was no treatment-related death. The lateral margin was positive for neoplasm in 3 lesions (4.3%) and inconclusive in 27 lesions (38.6%), but no local recurrence was observed. Cervical lymph node metastasis was observed in 6 patients, and was successfully treated by cervical lymph node dissection. The three-year overall survival rate was 91.5% (95%CI: 76.6-97.3%) and the cause-specific survival rate was 97.6% (95%CI: 84.9-99.7%). In conclusion, ESD for superficial pharyngeal cancer was safe and effective. "Resect and watch" is probably a feasible and rational strategy for treatment of patients with superficial pharyngeal cancer.

DOI： 10.18926/AMO/56646

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Gastric Emphysema in a Critically Ill Patient Successfully Treated without Surgery. Reviewed International journal

Hiromi Ihoriya, Tetsuya Yumoto, Masaya Iwamuro, Noritomo Fujisaki, Takaaki Osako, Hiromichi Naito, Atsunori Nakao

Case reports in critical care 2019 1824101 - 1824101 2019.3

Language：English

Gastric emphysema is a relatively rare clinical entity caused by injury to the gastric mucosa. A 62-year-old Japanese male with a history of heavy alcohol consumption and smoking was admitted to the emergency intensive care unit due to severe hypercapnic respiratory acidosis. His body mass index was only 12.6. Ten days after initiation of enteral feeding, he complained of abdominal pain. Computed tomography revealed intraluminal air in the distended gastric wall. Esophagogastroduodenoscopy showed diffuse edema, redness, and erosion throughout the stomach. Based on the findings of narrow angle and short distance of the aorta-superior mesenteric artery, the patient was diagnosed with gastric emphysema associated with superior mesenteric artery syndrome. He was successfully managed nonoperatively with treatments including intravenous antibiotics, gastric decompression, and bowel rest. Physicians should be aware of this unusual condition in such critically ill patients complaining of abdominal pain and needing close monitoring and observation to exclude gastric necrosis or perforation.

DOI： 10.1155/2019/1824101

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高齢者における早期胃癌に対するESD非治癒切除症例の検討

岡本雄貴, 後藤田達洋, 濱田健太, 馬場雄己, 大林由佳, 榮浩行, 安部真, 神崎洋光, 岩室雅也, 川野誠司, 田中健大, 河原祥朗, 岡田裕之

日本高齢消化器病学会誌 21 ( 2 ) 6 - 13 2019.3

消化管神経内分泌腫瘍の臨床病理学的特徴

神崎洋光, 筑木隆雄, 岡田裕之, 岡本雄貴, 大林由佳, 馬場雄己, 濱田健太, 安部真, 後藤田達洋, 岩室雅也, 原田馨太, 川野誠司

日本消化器病学会雑誌 116 ( 臨増総会 ) A269 - A269 2019.3

早期胃がんの内視鏡治療後にダビガトラン起因性食道炎を呈した1例

岩室雅也, 川野誠司, 河原祥朗, 田中健大, 岡田裕之

内科 123 ( 3 ) 465 - 468 2019.3

尋常性天疱瘡でみられた生検時の食道上皮剥離

岩室雅也, 田中健大, 岡田裕之

Gastroenterological Endoscopy 61 ( 3 ) 286 - 286 2019.3

咽頭ESD後の下咽頭の変形と誤嚥性肺炎の発症に関する検討

安部真, 河原祥朗, 岡本雄貴, 大林由佳, 馬場雄己, 榮浩行, 後藤田達洋, 神崎洋光, 岩室雅也, 川野誠司, 津村宗近, 牧野琢丸, 野田洋平, 丸中秀格, 岡田裕之

耳鼻咽喉科展望 62 ( 1 ) 51 - 51 2019.2

Heterotopic bone formation in the esophagus. International journal

Masaya Iwamuro, Hiroyuki Sakae, Takehiro Tanaka, Hiroyuki Okada

Gastrointestinal endoscopy 89 ( 2 ) 429 - 430 2019.2

消化管悪性リンパ腫の診断における生検材料を用いたFlow Cytometry法の有用性

岩室雅也, 松枝克典, 表静馬, 大塚文男, 岡田裕之

日本内科学会雑誌 108 ( Suppl. ) 215 - 215 2019.2

Gastric lanthanum phosphate deposition masquerading as white globe appearance. Reviewed International journal

Masaya Iwamuro, Haruo Urata, Takehiro Tanaka, Hiroyuki Okada

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 51 ( 1 ) 168 - 168 2019.1

Two cases of gastric mucosa-associated lymphoid tissue (MALT) lymphoma masquerading as follicular gastritis. International journal

Masaya Iwamuro, Takehiro Tanaka, Kenji Nishida, Hiromitsu Kanzaki, Seiji Kawano, Yoshiro Kawahara, Tadashi Yoshino, Hiroyuki Okada

Ecancermedicalscience 13 933 - 933 2019

Language：English

In this report, we describe two cases of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) of the stomach, which presented with multiple small, whitish nodules in the gastric body. The endoscopic appearance was similar to that of lymphoid follicular hyperplasia found in follicular gastritis or nodular gastritis. Both patients were positive for Helicobacter pylori, and the eradication treatment resulted in complete remission of the lymphoma. However, recurrence was noted in one patient. These cases indicate that, although infrequent, gastric MALT lymphoma can show a nodular appearance resembling that of follicular gastritis.

DOI： 10.3332/ecancer.2019.933

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[Peutz-Jeghers syndrome and cancer:a retrospective study in 14 Japanese patients with Peutz-Jeghers syndrome].

Masaya Iwamuro, Tatsuya Toyokawa, Yuki Moritou, Kazuhiro Matsueda, Shinichiro Hori, Masao Yoshioka, Takehiro Tanaka, Seiji Kawano, Hiroyuki Okada

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 116 ( 12 ) 1015 - 1021 2019

Language：Japanese Publishing type：Research paper (scientific journal)

We retrospectively investigated 14 Japanese patients with Peutz-Jeghers (PJ) syndrome who were treated in six hospitals to determine the prevalence of cancer in Japanese patients with PJ syndrome. The study included seven males and seven females. The mean age at the time of diagnosis of PJ syndrome was 28.1 years (range 2-60 years). Hamartomatous polyps were observed in 13 (92.9%) patients, mucocutaneous pigmentation in 11 (78.6%), and positive family history in six patients (42.9%). The mean observation period after the diagnosis of PJ syndrome was 10.1 years (range 0-34 years). Although one patient died of cancer of unknown primary origin, the remaining 13 patients included in the study completed their last follow-up at each hospital. Cancers were detected in six patients (42.9%), including cancer of the uterine cervix (N=3), breast cancer (N=1), duodenal cancer (N=1), transverse colon cancer (N=1), and cancer of unknown primary origin (N=1). One patient presented with both cervical cancer and breast cancer. No patient presented with pancreatic cancer. This study highlights that patients with PJ syndrome are at high risk for intestinal and extra-intestinal cancers, such as uterine and breast cancer. Routine surveillance for intestinal and extra-intestinal malignancies is warranted in patients with PJ syndrome.

DOI： 10.11405/nisshoshi.116.1015

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適応拡大前後における院内紹介例からみた小腸カプセル内視鏡施行内容の検討院内への啓発活動にむけて

川野誠司, 岩室雅也, 井口俊博, 杉原雄策, 原田馨太, 平岡佐規子, 岡田裕之

岡山医学会雑誌 130 ( 3 ) 155 - 159 2018.12

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