Updated on 2024/02/02

写真a

 
TODA Hironobu
 
Organization
Okayama University Hospital Special-Appointment Assistant Professor
Position
Special-Appointment Assistant Professor
Profile

1999年 広島大学 入学
2005年 広島大学 卒業
岡山赤十字病院 初期研修医
2007年 福山市民病院 後期研修医 内科・救急科
2008年~ 福山市民病院 循環器内科
2012年~ 岡山大学医歯薬学総合研究科 大学院
2013年~ 岡山大学 循環器内科
2018年7月~ 岡山大学 循環器内科 助教


資格: 医学博士
日本内科学会認定医、総合内科専門医
日本循環器学会専門医
日本心血管インターベンション学会認定医・専門医
日本脈管学会専門医 経カテーテル的大動脈弁置換術 Sapien・Corevalve 指導医

臨床研修指導医講習会受講

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Degree

  • 博士課程 ( 2017.3   岡山大学 )

Research Interests

  • 循環器内科学

  • インターベンション

Research Areas

  • Life Science / Cardiology

Education

  • Okayama University   医歯薬学総合研究科  

    2012.4 - 2016.3

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  • Hiroshima University   医学部   医学科

    1999.4 - 2005.3

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Professional Memberships

  • Japanese society of limb salvage and podiatric medicine

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  • The Japanese Circulation Society

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  • THE JAPANESE SOCIETY OF INTERNAL MEDICINE

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  • Japanese College of Angiology

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  • JAPANESE ASSOCIATION OF CARDIOVASCULAR INTERVENTION AND THERAPEUTICS

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  • Japan Transcatheter Valve Therapies

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Papers

  • Catheter-directed thrombolysis for critical hand ischemia with failed distal venous arterialization.

    Mitsutaka Nakashima, Hironobu Toda, Kentaro Ejiri, Susumu Ozawa, Satoshi Akagi, Kazufumi Nakamura

    Cardiovascular intervention and therapeutics   2023.8

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    DOI: 10.1007/s12928-023-00956-5

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  • Association Between Aortic Valve Calcification and Severity of Concomitant Aortic Regurgitation in Patients With Severe Aortic Stenosis.

    Fumi Yokohama, Yoichi Takaya, Keishi Ichikawa, Rie Nakayama, Takashi Miki, Hironobu Toda, Norihisa Toh, Toru Miyoshi, Kazufumi Nakamura, Hiroshi Ito

    Circulation journal : official journal of the Japanese Circulation Society   2023.4

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    BACKGROUND: Patients with severe aortic stenosis (AS) frequently have concomitant aortic regurgitation (AR), but the association between aortic valvular calcification (AVC) and the severity of AR remains unclear.Methods and Results: We retrospectively reviewed patients with severe AS who underwent transthoracic echocardiography and multidetector computed tomography (MDCT) within 1 month. The patients were divided into 3 groups according to the degree of concomitant AR. The association between AVC and the severity of concomitant AR was assessed in patients with severe AS. The study population consisted of 95 patients: 43 men and 52 women with a mean age of 82±7 years. Of the 95 patients with severe AS, 27 had no or trivial AR, 53 had mild AR, and 15 had moderate AR. The AVC score (AVCS) and AVC volume (AVCV) significantly increased as the severity of concomitant AR increased (P=0.014 for both), and similar findings were obtained for the AVCS and AVCV indexes (P=0.004 for both). CONCLUSIONS: The severity of AR correlated with AVCS and AVCV measured by MDCT in patients with severe AS. AVC may cause concomitant AR, leading to worsening of disease condition.

    DOI: 10.1253/circj.CJ-22-0746

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  • Association between home-based exercise using a pedometer and clinical prognosis after endovascular treatment in patients with peripheral artery disease. International journal

    Kohei Kawamura, Kentaro Ejiri, Hironobu Toda, Toshiaki Yamanaka, Masato Taniguchi, Kenji Kawamoto, Koji Tokioka, Yoichiro Naito, Ryo Yoshioka, Eiji Karashima, Hideki Fujio, Soichiro Fuke, Yasukazu Fujiwara, Atsushi Takaishi, Kosuke Seiyama, Toru Miyoshi, Kazufumi Nakamura, Hiroshi Ito

    Journal of cardiology   81 ( 2 )   222 - 228   2023.2

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    BACKGROUND: Exercise therapy following endovascular treatment (EVT) is important for patients with peripheral artery disease (PAD); however, continuous exercise therapy is difficult to be performed in clinical practice. This study aimed to investigate the association between the implementation of home-based exercise using pedometers after EVT and 1-year clinical outcomes. METHODS: This multicenter observational prospective cohort registry included patients with PAD complaining of intermittent claudication who underwent EVT for aortoiliac and/or femoropopliteal artery lesions between January 2016 and March 2019. Patients were instructed to perform home-based exercises using a specific pedometer after EVT. The study population was divided into good and poor recording groups according to the frequency of the pedometer measurements. The good recording group was defined as those who completed ≥50 % of the prescribed daily pedometer recording during the follow-up period. The poor recording group was defined as those with an inability to use a pedometer and/or who completed <50 % of the prescribed daily pedometer recordings. The primary outcome was 1-year major adverse events (MAE), defined as a composite of all-cause death, non-fatal myocardial infarction, non-fatal stroke, target vessel revascularization, and major amputation of the target limb. RESULTS: The mean age was 74.4 years; 78 % were male. A total of 623 lesions were analyzed (58.7 % aortoiliac, 41.3 % femoropopliteal). At 1 year, a lower cumulative incidence of MAE was observed in the good recording group compared to that in the poor recording group [10/233 (4.3 %) vs. 35/267 (13.7 %) patients, respectively; p < 0.001]. Multivariate Cox regression analysis showed that patients in the good recording group had a lower hazard ratio for 1-year MAE (0.33; 95 % confidence interval, 0.16-0.68; p = 0.004) than that in the poor recording group. CONCLUSIONS: Good self-recording of pedometer measurements was associated with favorable prognosis in patients with PAD following EVT.

    DOI: 10.1016/j.jjcc.2022.09.005

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  • ベーチェット病により腎動脈狭窄症をきたした1例

    内田 治仁, 戸田 洋伸, 武本 梨佳, 岡本 修吾, 竹内 英実, 梅林 亮子, 和田 淳

    脈管学   62 ( Suppl. )   S182 - S183   2022.10

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  • 異なる経過をたどった腎動脈狭窄を伴う高安動脈炎の2症例

    武本 梨佳, 内田 治仁, 戸田 洋伸, 岡本 修吾, 竹内 英実, 梅林 亮子, 大塚 文男, 伊藤 浩, 和田 淳

    脈管学   62 ( Suppl. )   S195 - S195   2022.10

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  • 異なる経過をたどった腎動脈狭窄を伴う高安動脈炎の2症例

    武本 梨佳, 内田 治仁, 戸田 洋伸, 岡本 修吾, 竹内 英実, 梅林 亮子, 大塚 文男, 伊藤 浩, 和田 淳

    脈管学   62 ( Suppl. )   S195 - S195   2022.10

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  • 肝腎症候群急性期に冠攣縮によるST上昇型急性下壁心筋梗塞を合併し,集学的治療により救命し得た1例

    長田 栞, 中島 充貴, 戸田 洋伸, 平井 亮佑, 高木 章乃夫, 三木 崇史, 赤木 達, 吉田 賢司, 中村 一文, 赤木 禎治, 森田 宏, 伊藤 浩

    心臓   54 ( 10 )   1164 - 1169   2022.10

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    43歳男性.非代償性アルコール性肝硬変のため他院で通院加療を行われていた.特発性細菌性腹膜炎を契機とした肝腎症候群による急性腎障害を発症し当院転院となった.著明なアシドーシスおよび腎不全を認め集中治療室に入室した.入院後,下壁誘導ST上昇および高度房室ブロックを生じショック状態に至った.気管挿管を行いアルブミン補充および昇圧薬を使用して呼吸循環を維持し,持続的血液濾過透析を施行しながら緊急冠動脈造影検査を施行した.右冠動脈中間部90%狭窄,左冠動脈前下行枝近位部90%狭窄,左冠動脈回旋枝中間部90%狭窄を認めたが,血管拡張薬冠注により狭窄は解除され冠攣縮に伴うST上昇型急性下壁心筋梗塞と診断した.ニコランジル持続静脈投与を開始しST変化や房室ブロックの再発を認めなかった.血行動態安定し,全身状態も改善に向かった.肝腎症候群は末期肝硬変に続発する腎皮質血管の攣縮により生じるとされ,肝・腎以外の臓器にも血流障害が併存する可能性を示唆されている.今回我々は肝腎症候群に冠攣縮による急性心筋梗塞を発症し,集学的治療により救命し得た1例を経験したためここに報告する.(著者抄録)

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    Other Link: https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J00679&link_issn=&doc_id=20221018180015&doc_link_id=%2Fah2sinzd%2F2022%2F005410%2F019%2F1164-1169%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fah2sinzd%2F2022%2F005410%2F019%2F1164-1169%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • Effects of luseogliflozin and voglibose on high-risk lipid profiles and inflammatory markers in diabetes patients with heart failure. International journal

    Kentaro Ejiri, Toru Miyoshi, Hajime Kihara, Yoshiki Hata, Toshihiko Nagano, Atsushi Takaishi, Hironobu Toda, Seiji Namba, Yoichi Nakamura, Satoshi Akagi, Satoru Sakuragi, Taro Minagawa, Yusuke Kawai, Nobuhiro Nishii, Soichiro Fuke, Masaki Yoshikawa, Kazufumi Nakamura, Hiroshi Ito

    Scientific reports   12 ( 1 )   15449 - 15449   2022.9

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    Sodium-glucose cotransporter 2 inhibitors could reduce cardiovascular events in patients with heart failure irrespective of diabetes status. In this prespecified sub-analysis of randomised-controlled trial, we investigated the efficacy of luseogliflozin (2.5 mg daily), a sodium-glucose cotransporter 2 inhibitor, with that of voglibose (0.6 mg daily), an alpha-glucosidase inhibitor, on high-risk lipid profile and inflammatory markers in patients with type-2 diabetes and heart failure. Among the 157 patients studied, there were no significant differences in the mean malondialdehyde LDL or small-dense LDL cholesterol levels between the luseogliflozin and voglibose groups (percent change: 0.2% vs. - 0.6%, p = 0.93; - 1.7% vs. - 8.6%, p = 0.21) after 12 weeks in comparison to levels at the baseline. No significant difference was observed between the two groups in the adiponectin and high-sensitivity C-reactive protein levels after 12 weeks compared to the baseline levels (percent change, - 1.6% vs. - 4.0% and 22.5% vs. 10.0%; p = 0.52 and p = 0.55, respectively). In conclusion, in patients with type-2 diabetes and heart failure, compared to voglibose, luseogliflozin did not significantly improve the high-risk lipoprotein profile including malondialdehyde LDL and small-dense LDL cholesterol or the levels of inflammatory markers, including adiponectin and high-sensitivity C-reactive protein.Trial registration: Trial number: UMIN-CTR, UMIN000018395; Registered 23 July 2015; URL: https://www.umin.ac.jp/ctr/index.htm .

    DOI: 10.1038/s41598-022-19371-6

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  • 2型糖尿病および左室駆出率が保たれた心不全患者におけるLuseogliflozinの推定血漿量への影響(Effects of Luseogliflozin on Estimated Plasma Volume in Patients with Type 2 Diabetes and Heart Failure with Preserved Ejection Fraction)

    中島 充貴, 三好 亨, 江尻 健太郎, 木原 一, 幡 芳樹, 長野 俊彦, 高石 篤志, 戸田 洋伸, 赤木 達, 櫻木 悟, 皆川 太郎, 伊藤 浩

    日本循環器学会学術集会抄録集   86回   JO09 - 1   2022.3

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  • Preventative effects of bisoprolol transdermal patches on postoperative atrial fibrillation in high-risk patients undergoing non-cardiac surgery: A subanalysis of the MAMACARI study. International journal

    Takayuki Iwano, Hironobu Toda, Kazufumi Nakamura, Kazuyoshi Shimizu, Kentaro Ejiri, Yoichiro Naito, Hisatoshi Mori, Takuro Masuda, Toru Miyoshi, Masashi Yoshida, Yukiko Hikasa, Hiroshi Morimatsu, Hiroshi Ito

    Journal of cardiology   78 ( 5 )   349 - 354   2021.11

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    BACKGROUND: Perioperative atrial fibrillation (POAF) after non-cardiac surgery is a risk factor for cardiovascular events including stroke and death. The aim of this subanalysis of the MAMACARI study, a multicenter randomized control study on the effectiveness of a bisoprolol transdermal patch for prevention of perioperative myocardial injury in high-risk patients undergoing non-cardiac surgery, was to identify the predictors of POAF after non-cardiac surgery in high-risk patients and to determine changes in blood pressure and heart rate during bisoprolol patch administration in the perioperative period. METHODS AND RESULTS: Patients aged over 60 years with hypertension and a high revised cardiac risk index (≥2) who were scheduled to undergo non-cardiac surgery were randomly assigned to a bisoprolol patch group (n = 120) or a control group (n = 120). We divided the patients into two groups: patients with POAF (POAF group; n = 16) and patients without POAF (non-POAF group; n = 206). Multivariate analysis showed that bisoprolol patch therapy (OR: 0.30, 95% CI: 0.092-0.978) and surgery time of 250 min or more (OR: 4.99, 95% CI: 1.37-18.2) were independently associated with POAF. Although systolic blood pressure did not differ significantly between the two groups throughout the perioperative period, treatment with a bisoprolol patch significantly reduced heart rate throughout the perioperative period compared with that in the control group. CONCLUSIONS: Low dose of a bisoprolol patch in the perioperative period was effective for prevention of POAF after non-cardiac surgery in high-risk patients, while long surgery time was an independent risk factor for POAF. It is expected that low dose of a bisoprolol patch can prevent POAF without causing hypotension.

    DOI: 10.1016/j.jjcc.2021.05.001

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  • Total vascular resistance, augmentation index, and augmentation pressure increase in patients with peripheral artery disease. International journal

    Rika Takemoto, Haruhito A Uchida, Hironobu Toda, Ken Okada, Fumio Otsuka, Hiroshi Ito, Jun Wada

    Medicine   100 ( 32 )   e26931   2021.8

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    ABSTRACT: Peripheral arterial disease (PAD) is one of major vascular diseases which frequently coexists with coronary arterial disease and cerebrovascular disease. The patients with PAD have a poor prognosis when it progresses. A new blood pressure testing device enables to simultaneously measure brachial blood pressure (BP), central BP, and several vascular parameters, with easy and non-invasive, in a short time. Here, we aimed to evaluate these arterial stiffness parameters in patients with PAD.In this study, 243 consecutive patients who were suspected of having PAD and referred to our hospital from September 2016 to June 2019, were registered. Several parameters, such as brachial BP, central BP, aortic pulse wave velocity (aPWV), total vascular resistance (TVR), augmentation index (AI) and augmentation pressure (AP), were determined by Mobil-O-Graph. Ankle-brachial pressure index (ABI) was used to define PAD (ABI ≤ 0.9 as PAD). The relationship between PAD and central BP, aPWV, TVR, AI, or AP were investigated.One hundred sixty-two patients (67%) were categorized as the PAD group and 81 patients (33%) as the non-PAD group. In the PAD group, the systolic brachial BP and central systolic BP were significantly higher than those in the non-PAD group (138 ± 24 mmHg vs 131 ± 19 mmHg, P < .05, 125 ± 22 mmHg vs 119 ± 18 mmHg, P < .05, respectively). TVR, AI, and AP were significantly higher in the PAD group (1785 ± 379 dyn s/cm5 vs 1661 ± 317 dyn s/cm5, P < .05, 26.2 ± 13.0% vs 22.2 ± 13.3%, P < .05, 13.5 ± 9.4 mmHg vs 10.7 ± 7.2 mmHg, P < .05, respectively). No significant differences in diastolic BP, central diastolic BP, and aPWV were found between the groups. Multivariate logistic regression analysis revealed that PAD was significantly associated with TVR, AI, and AP (P < .05, respectively).TVR/AP/AI were significantly higher in the PAD group than in the non-PAD group.

    DOI: 10.1097/MD.0000000000026931

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  • Higher oxidized high-density lipoprotein to apolipoprotein A-I ratio is associated with high-risk coronary plaque characteristics determined by CT angiography. International journal

    Kazuki Suruga, Toru Miyoshi, Kazuhiko Kotani, Keishi Ichikawa, Takashi Miki, Kazuhiro Osawa, Kentaro Ejiri, Hironobu Toda, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Ito

    International journal of cardiology   324   193 - 198   2021.2

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    BACKGROUND: Oxidized high-density lipoprotein (oxHDL), unlike native HDL, is characterized by reduced cholesterol efflux capability and anti-inflammatory properties. The ratio of oxHDL to apolipoprotein A-I (oxHDL/apoAI) is a possible marker of dysfunctional HDL. The aim of this study was to evaluate the association between oxHDL/apoAI and coronary plaque characteristics that increase the likelihood of cardiovascular events as determined by coronary computed tomography (CT) angiography. METHODS: A total of 297 patients (mean age; 67 years, men; 63%) who underwent coronary CT angiography for suspected stable coronary artery disease (CAD) were included. High-risk plaques (HRP) were defined by three characteristics: positive remodeling; low-density plaques; and spotty calcification. Significant stenosis was defined as a luminal narrowing of >70%. Serum concentrations of oxHDL were measured using an enzyme-linked immunosorbent assay. RESULTS: Patients with higher oxHDL/ApoAI showed significantly greater prevalence of HRP (p = 0.03) and significant stenosis (p < 0.01) compared with patients with low oxHDL/ ApoAI. The multivariate logistic analysis demonstrated that oxHDL/ApoAI significantly associated with the presence of HRP and significant coronary stenosis (p = 0.01 and < 0.01). In the follow-up study including 243 patients for a median period of 1.8 years, univariate cox regression analysis showed that oxHDL/ApoAI, HRP and significant stenosis were significant predictors of cardiovascular events. CONCLUSIONS: A high oxHDL/apoAI was associated with the presence of HRP and significant stenosis determined by coronary CT angiography, which can lead to cardiovascular events in patients with suspected stable CAD.

    DOI: 10.1016/j.ijcard.2020.09.060

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  • 末梢動脈疾患が動脈スティフネスパラメータに与える影響の検討

    武本 梨佳, 内田 治仁, 戸田 洋伸, 大塚 文男, 伊藤 浩, 和田 淳

    脈管学   60 ( Suppl. )   S172 - S172   2020.10

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  • Effect of Luseogliflozin on Heart Failure With Preserved Ejection Fraction in Patients With Diabetes Mellitus. International journal

    Kentaro Ejiri, Toru Miyoshi, Hajime Kihara, Yoshiki Hata, Toshihiko Nagano, Atsushi Takaishi, Hironobu Toda, Seiji Nanba, Yoichi Nakamura, Satoshi Akagi, Satoru Sakuragi, Taro Minagawa, Yusuke Kawai, Nobuhiro Nishii, Soichiro Fuke, Masaki Yoshikawa, Kazufumi Nakamura, Hiroshi Ito

    Journal of the American Heart Association   9 ( 16 )   e015103   2020.8

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    Background Effects of sodium-glucose cotransporter 2 inhibitors on reducing hospitalization for heart failure have been reported in randomized controlled trials, but their effects on patients with heart failure with preserved ejection fraction (HFpEF) are unknown. This study aimed to evaluate the drug efficacy of luseogliflozin, a sodium-glucose cotransporter 2 inhibitor, in patients with type 2 diabetes mellitus and HFpEF. Methods and Results We performed a multicenter, open-label, randomized, controlled trial for comparing luseogliflozin 2.5 mg once daily with voglibose 0.2 mg 3 times daily in patients with type 2 diabetes mellitus suffering from HFpEF (left ventricular ejection fraction >45% and BNP [B-type natriuretic peptide] concentrations ≥35 pg/mL) in a 1:1 randomization fashion. The primary outcome was the difference from baseline in BNP levels after 12 weeks of treatment between the 2 drugs. A total of 173 patients with diabetes mellitus and HFpEF were included. Of these, 83 patients were assigned to receive luseogliflozin and 82 to receive voglibose. There was no significant difference in the reduction in BNP concentrations after 12 weeks from baseline between the 2 groups. The ratio of the mean BNP value at week 12 to the baseline value was 0.79 in the luseogliflozin group and 0.87 in the voglibose group (percent change, -9.0% versus -1.9%; ratio of change with luseogliflozin versus voglibose, 0.93; 95% CI, 0.78-1.10; P=0.26). Conclusion In patients with type 2 diabetes mellitus and HFpEF, there is no significant difference in the degree of reduction in BNP concentrations after 12 weeks between luseogliflozin and voglibose. Registration URL: https://www.umin.ac.jp/ctr/index.htm; Unique identifier: UMIN000018395.

    DOI: 10.1161/JAHA.119.015103

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  • Effects of Bisoprolol Transdermal Patches for Prevention of Perioperative Myocardial Injury in High-Risk Patients Undergoing Non-Cardiac Surgery - Multicenter Randomized Controlled Study. Reviewed

    Hironobu Toda, Kazufumi Nakamura, Kazuyoshi Shimizu, Kentaro Ejiri, Takayuki Iwano, Toru Miyoshi, Koji Nakagawa, Masashi Yoshida, Atsuyuki Watanabe, Nobuhiro Nishii, Yukiko Hikasa, Masao Hayashi, Hiroshi Morita, Hiroshi Morimatsu, Hiroshi Ito

    Circulation journal : official journal of the Japanese Circulation Society   84 ( 4 )   642 - 649   2020.3

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    BACKGROUND: The aim of this study was to evaluate the efficacy and safety of transdermal β-blocker patches, which offer stable blood concentration and easy availability during operation, for prevention of perioperative myocardial injury (PMI) in high-risk patients.Methods and Results:In this randomized controlled trial, patients aged >60 years with hypertension and high revised cardiac risk index (≥2) undergoing non-cardiac surgery were randomly assigned to a bisoprolol patch or control group. Primary efficacy outcome was incidence of PMI, defined as postoperative high-sensitivity cardiac troponin T (hs-cTnT) >0.014ng/mL and relative hs-cTnT change ≥20%. Secondary efficacy outcomes were number of cardiovascular events and 30-day mortality. From November 2014 to February 2019, 240 patients from 5 hospitals were enrolled in this study. The incidence of PMI was 35.7% in the bisoprolol patch group and 44.5% in the control group (P=0.18). Incidence of major adverse cardiac events including non-critical myocardial infarction, strokes, decompensated heart failure and tachyarrhythmia was similar between the 2 groups. Tachyarrhythmia tended to be higher in the control group. There were no significant differences in safety outcomes including significant hypotension and bradycardia requiring any treatment between the 2 groups. CONCLUSIONS: Bisoprolol patches do not influence the incidence of PMI and cardiovascular events in high-risk patients undergoing non-cardiac surgery, but perioperative use of these patches is safe.

    DOI: 10.1253/circj.CJ-19-0871

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  • PAD患者におけるTotal Vascular ResistanceおよびAugmentation Pressureに関する検討

    内田 治仁, 武本 梨佳, 松岡 奈津美, 大西 康博, 岡本 修吾, 西脇 麻里子, 秦 昌紫子, 大高 望, 戸田 洋伸, 北川 正史, 和田 淳

    日本高血圧学会総会プログラム・抄録集   42回   348 - 348   2019.10

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  • 18歳時に経皮的腎動脈形成術を行い10年以上経過して血圧上昇をきたした高安動脈炎の1例

    内田 治仁, 戸田 洋伸, 藤本 竜一, 大塚 寛昭, 花山 宜久, 武本 梨佳, 大西 康博, 高杉 佳奈子, 梅林 亮子, 吉田 賢司, 和田 淳

    脈管学   59 ( Suppl. )   S226 - S226   2019.10

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  • 遺残坐骨動脈瘤に対しステントグラフト(VIABAHN)を用いて治療した一例 Reviewed

    大塚 寛昭, 戸田 洋伸, 江尻 健太郎, 杜 徳尚, 三好 亨, 中村 一文, 伊藤 浩

    日本心血管インターベンション治療学会抄録集   28回   [MP34 - 006]   2019.9

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  • 安定狭心症患者の機能的狭窄評価におけるFFRCTの有用性 Reviewed

    三木 崇史, 三好 亨, 市川 啓之, 江尻 健太郎, 大塚 寛昭, 吉田 雅言, 戸田 洋伸, 伊藤 浩

    日本心血管インターベンション治療学会抄録集   28回   [MO119 - 001]   2019.9

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  • 右冠動脈完全閉塞の治療が機能性僧帽弁逆流の改善に寄与したCHIP症例 Reviewed

    吉田 雅言, 三木 崇史, 江尻 健太郎, 大塚 寛昭, 戸田 洋伸, 中川 晃志, 三好 亨, 西井 伸洋, 渡邊 あつゆき, 赤木 禎治, 伊藤 浩

    日本心血管インターベンション治療学会抄録集   28回   [MO134 - 003]   2019.9

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  • 高安病患者に対する経皮的腎血管形成術

    小倉 聡一郎, 戸田 洋伸, 藤本 竜平, 大塚 寛昭, 森田 宏, 伊藤 浩

    日本心血管インターベンション治療学会抄録集   28回   [MP18 - 005]   2019.9

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  • Combination of Renal Angioplasty and Angiotensin-converting-enzyme Inhibitor Can Reduce Proteinuria in Patients with Bilateral Renal Artery Disease. Reviewed

    Hironobu Toda, Haruhito Uchida, Kazufumi Nakamura, Hidemi Takeuchi, Masaru Kinomura, Koji Nakagawa, Atsuyuki Watanabe, Toru Miyoshi, Nobuhiro Nishii, Hiroshi Morita, Jun Wada, Hiroshi Ito

    Internal medicine (Tokyo, Japan)   58 ( 13 )   1917 - 1922   2019.7

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    Recent large clinical trials failed to show clear benefits of percutaneous transluminal renal angioplasty (PTRA) as compared with medical therapy on patients with renal artery stenosis. It was also reported that proteinuria is an adverse prognostic factor after PTRA, and PTRA is less effective in patients with overt proteinuria. From the renoprotective point of view, to reduce proteinuria after PTRA is an important therapeutic goal in patients with renal artery stenosis with overt proteinuria. We hereby describe two patients successfully treated by combination therapy with PTRA and administration of angiotensin-converting enzyme (ACE) inhibitor for bilateral renal artery disease with overt proteinuria.

    DOI: 10.2169/internalmedicine.2076-18

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  • Emerging Role of Coronary Computed Tomography Angiography in Lipid-Lowering Therapy: a Bridge to Image-Guided Personalized Medicine. Reviewed International journal

    Toru Miyoshi, Kazuhiro Osawa, Keishi Ichikawa, Kazuki Suruga, Takashi Miki, Masashi Yoshida, Koji Nakagawa, Hironobu Toda, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Ito

    Current cardiology reports   21 ( 8 )   72 - 72   2019.6

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    PURPOSE OF REVIEW: To summarize the current status of coronary computed tomography angiography (CTA) in the assessment of coronary plaques and discuss the ability of serial coronary CTA to quantitatively measure changes in the plaque burden in response to lipid-lowering therapy. RECENT FINDINGS: Recent advances in coronary CTA have allowed identification of high-risk coronary features in acute coronary syndrome and measurement of changes in the coronary plaque burden with good reproducibility. Statin therapy may delay plaque progression and change some plaque features. However, the clinical relevance of quantitative changes in coronary plaques and the optimal methods to reduce the plaque burden remain unclear. Despite guideline-directed lipid-lowering therapy, adverse events still occur in substantial numbers of patients receiving statins. Coronary CTA is noninvasive and has high diagnostic performance in patients with coronary artery disease, making change in the plaque burden an applicable biomarker for individualized assessment of future risk.

    DOI: 10.1007/s11886-019-1170-4

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  • CLI診療(循環器内科医に求められる役割について) Reviewed

    大塚 寛昭, 戸田 洋伸, 江尻 健太郎, 三好 亨, 中村 一文, 森田 宏, 伊藤 浩

    日本下肢救済・足病学会誌   11 ( 1 )   58 - 58   2019.4

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  • Coral reef aorta一連の病変と考えられた移植腎動脈狭窄に対する血管内治療の1例 Reviewed

    戸田 洋伸, 大塚 寛昭, 江尻 健太郎, 内田 治仁, 杜 徳尚, 中川 晃志, 渡邊 敦之, 三好 亨, 西井 伸洋, 中村 一文, 森田 宏, 伊藤 浩

    脈管学   58 ( Suppl. )   S206 - S206   2018.9

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  • 超音波検査にて経時的変化の観察が可能であった巨細胞性動脈炎の2症例

    武本 梨佳, 内田 治仁, 戸田 洋伸, 竹内 英実, 大高 望, 大塚 寛昭, 大塚 文男, 伊藤 浩, 和田 淳

    脈管学   58 ( Suppl. )   S211 - S211   2018.9

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  • 末梢動脈疾患が中心血圧、aPWV、AIに与える影響の検討

    武本 梨佳, 内田 治仁, 垣尾 勇樹, 大高 望, 大西 康博, 秦 昌紫子, 北川 正史, 戸田 洋伸, 吉田 賢司, 大塚 文男, 杉山 斉, 伊藤 浩, 和田 淳

    日本高血圧学会総会プログラム・抄録集   41回   PM01 - 03   2018.9

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  • 重度低心機能患者に発症した重症下肢虚血、糖尿病性壊疽に対し集学的治療を行った一例 Reviewed

    大塚 寛昭, 戸田 洋伸, 江尻 健太郎, 奥山 倫弘, 大澤 晋, 山田 潔, 三好 亨, 中村 一文, 伊藤 浩

    日本下肢救済・足病学会誌   10 ( 1 )   83 - 83   2018.6

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  • Diastolic Dysfunction Is a Risk of Perioperative Myocardial Injury Assessed by High-Sensitivity Cardiac Troponin T in Elderly Patients Undergoing Non-Cardiac Surgery. Reviewed

    Hironobu Toda, Kazufumi Nakamura, Koji Nakagawa, Atsuyuki Watanabe, Toru Miyoshi, Nobuhiro Nishii, Kazuyoshi Shimizu, Masao Hayashi, Hiroshi Morita, Hiroshi Morimatsu, Hiroshi Ito

    Circulation journal : official journal of the Japanese Circulation Society   82 ( 3 )   775 - 782   2018.2

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    BACKGROUND: High-sensitivity cardiac troponin T (hs-cTnT) is useful for detecting myocardial injury and is expected to become a prognostic marker in patients undergoing non-cardiac surgery. The aim of this pilot study evaluating the efficacy of β-blocker therapy in a perioperative setting (MAMACARI study) was to assess perioperative myocardial injury (PMI) in elderly patients with preserved ejection fraction (EF) undergoing non-cardiac surgery.Methods and Results:In this prospective observational cohort study of 151 consecutive patients with preserved EF and aged >60 years who underwent non-cardiac surgery, serum levels of hs-cTnT were measured before and on postoperative days 1 and 3 after surgery. PMI was defined as postoperative hs-cTnT >0.014 ng/mL and relative hs-cTnT change ≥20%. A total of 36 (23.8%) of the patients were diagnosed as having PMI. The incidence of a composite of cardiovascular events within 30 days after surgery, including myocardial infarction, stroke, worsening heart failure, atrial fibrillation and pulmonary embolism, was significantly higher in patients with PMI than in patients without PMI (odds ratio (OR) 9.25, P<0.001, 95% confidence interval (CI) 2.65-32.3). Multivariate analysis revealed that left ventricular diastolic dysfunction defined by echocardiography was independently associated with PMI (OR: 3.029, 95% CI: 1.341-6.84, P=0.008). CONCLUSIONS: PMI is frequently observed in elderly patients undergoing non-cardiac surgery. Diastolic dysfunction is an independent predictor of PMI.

    DOI: 10.1253/circj.CJ-17-0747

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  • 閉塞性動脈硬化症診断におけるトレッドミル負荷ABIの有用性 Reviewed

    武本 梨佳, 戸田 洋伸, 越智 真金, 大塚 寛昭, 江尻 健太郎, 内田 治仁, 岡田 健, 大塚 文男, 和田 淳, 伊藤 浩

    脈管学   57 ( Suppl. )   S260 - S260   2017.10

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  • 両側上腕血圧測定不能を契機に発見された巨細胞性動脈炎の1例 Reviewed

    武本 梨佳, 内田 治仁, 戸田 洋伸, 江尻 健太郎, 竹内 英実, 垣尾 勇樹, 奥山 由加, 岡田 健, 大塚 文男, 伊藤 浩, 和田 淳

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集   6回   177 - 177   2017.5

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  • 結節性多発動脈炎をベースとした腎動脈狭窄症に経皮的腎動脈形成術(PTRA)を行った1例

    竹内 英実, 内田 治仁, 大高 望, 垣尾 勇樹, 江尻 健太朗, 戸田 洋伸, 杉山 斉, 和田 淳

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集   6回   169 - 169   2017.5

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  • 超音波検査にて経過観察が可能であった巨細胞性動脈炎の1例 Reviewed

    武本 梨佳, 内田 治仁, 戸田 洋伸, 江尻 健太郎, 藤井 泰宏, 大澤 晋, 竹内 英実, 鳴海 淳子, 料治 三恵, 麻植 浩樹, 岡田 健, 大塚 文男, 伊藤 浩, 和田 淳

    脈管学   56 ( Suppl. )   S232 - S232   2016.10

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  • 脳梗塞を発症した、頸動脈・腎動脈狭窄症を呈した若年男性の1例 Reviewed

    武本 梨佳, 内田 治仁, 戸田 洋伸, 竹内 麻梨, 中村 知子, 戸田 由香, 渡辺 修久, 江尻 健太郎, 麻植 浩樹, 岡田 健, 大塚 文男, 伊藤 浩

    超音波検査技術   41 ( 5 )   584 - 584   2016.10

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  • 冠動脈ハイリスクプラークの予測におけるトリグリセリド/HDLコレステロール比の有用性について Reviewed

    三木 崇史, 三好 亨, 小出 祐嗣, 江尻 健太郎, 戸田 洋伸, 吉田 雅言, 中村 一文, 森田 宏, 伊藤 浩

    日本心臓病学会学術集会抄録   64回   P - 116   2016.9

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  • [Medical therapy for angina pectoris]. Reviewed

    Hironobu Toda, Hiroshi Ito

    Nihon rinsho. Japanese journal of clinical medicine   74 Suppl 6   22 - 5   2016.8

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  • FFR-CTの使用経験 実臨床における20症例についての検討 Reviewed

    三木 崇史, 三好 亨, 小出 祐嗣, 戸田 洋伸, 吉田 雅言, 江尻 健太郎, 伊藤 浩

    日本心血管インターベンション治療学会抄録集   25回   MO102 - MO102   2016.7

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  • [Beta-blockers]. Reviewed

    Hironobu Toda, Hiroshi Ito

    Nihon rinsho. Japanese journal of clinical medicine   74 Suppl 4 Pt 1   581 - 5   2016.6

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  • 右総頸動脈に収縮期に逆行性血流を呈した腕頭動脈閉塞の1例 Reviewed

    武本 梨佳, 戸田 洋伸, 戸田 由香, 勢井 麻梨, 中村 知子, 渡辺 修久, 江尻 健太郎, 麻植 浩樹, 杉生 憲志, 岡田 健, 大塚 文男, 伊藤 浩

    超音波検査技術   41 ( Suppl. )   S230 - S230   2016.6

  • Clinical characteristics of responders to treatment with tolvaptan in patients with acute decompensated heart failure: Importance of preserved kidney size. Reviewed International journal

    Hironobu Toda, Kazufumi Nakamura, Makoto Nakahama, Tadashi Wada, Atsuyuki Watanabe, Katsushi Hashimoto, Ritsuko Terasaka, Koji Tokioka, Nobuhiro Nishii, Toru Miyoshi, Kunihisa Kohno, Yusuke Kawai, Kohei Miyaji, Yuji Koide, Motomi Tachibana, Ryo Yoshioka, Hiroshi Ito

    Journal of cardiology   67 ( 2 )   177 - 83   2016.2

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    BACKGROUND: Recent clinical trials have demonstrated the efficacy of short-term treatment with tolvaptan, an oral vasopressin V2 receptor antagonist, in patients with heart failure. However, the response to tolvaptan varies among patients. The aim of this study was to determine factors associated with response to tolvaptan in patients with acute decompensated heart failure (ADHF). METHODS: The Tolvaptan Registry, a prospective, observational, multicenter cohort study performed in Japan, aims to determine factors affecting the responsiveness of tolvaptan in patients with ADHF. We enrolled ADHF patients treated with tolvaptan and they were divided into two groups: responders and non-responders. Responders were defined as subjects who met all of the following three conditions: (1) increasing urine volume during a 24-hour period after the start of tolvaptan treatment; (2) improvement in New York Heart Association functional class; and (3) decrease in cardiothoracic ratio assessed by chest X-ray on day 3 of tolvaptan administration. RESULTS: Among the 114 patients, treatment with tolvaptan improved three conditions of heart failure in more than half of all the cohorts (71 patients, 62%). As for baseline characteristics, estimated glomerular filtration rate, urine osmolality, and kidney size were significantly greater in responders than in non-responders. Multivariate logistic analysis revealed that kidney size was independently associated with responders (odds ratio: 1.083, p=0.001, 95% confidence interval 1.031-1.137). CONCLUSIONS: The main clinical characteristic of responders to treatment with tolvaptan is that kidney size is preserved.

    DOI: 10.1016/j.jjcc.2015.04.017

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  • 脳梗塞を発症した、頸動脈狭窄症及び腎動脈狭窄症を呈した若年男性の1例 Reviewed

    武本 梨佳, 内田 治仁, 戸田 洋伸, 勢井 麻梨, 中村 知子, 戸田 由香, 江尻 健太郎, 麻植 浩樹, 岡田 健, 大塚 文男, 伊藤 浩

    脈管学   55 ( Suppl. )   S246 - S246   2015.10

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  • 下大静脈フィルター閉塞が誘因となった症候性下肢動静脈瘻の2症例 Reviewed

    大澤 晋, 藤井 泰宏, 藤原 寛康, 増田 善逸, 黒子 洋介, 戸田 洋伸, 内田 治仁, 村上 和敏, 江尻 健太郎, 高樽 由美, 料治 三恵, 逢坂 大樹, 竹内 英実, 武本 梨佳, 本田 雅子, 三宅 麻希, 佐野 俊二

    脈管学   55 ( Suppl. )   S212 - S212   2015.10

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  • Dual antiplatelet therapy can be discontinued at three months after implantation of zotarolimus-eluting stent in patients with coronary artery disease. Reviewed International journal

    Tadashi Wada, Makoto Nakahama, Hironobu Toda, Atsuyuki Watanabe, Katsushi Hashimoto, Ritsuko Terasaka, Kazufumi Nakamura, Nobuyuki Yamada, Hiroshi Ito

    ISRN cardiology   2013   518968 - 518968   2013

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    Dual antiplatelet therapy (DAPT) after percutaneous coronary intervention increases the risk of bleeding. We studied the safety and clinical outcomes of switching from DAPT to aspirin monotherapy at 3 months after ZES implantation. We retrospectively evaluated 168 consecutive patients with coronary artery disease who had been implanted with a ZES from June 2009 through March 2010. After excluding 40 patients according to exclusion criteria such as myocardial infarction, 128 patients were divided into a 3-month DAPT group (67 patients, 88 lesions) and a 12-month conventional DAPT group (61 patients, 81 lesions). Coronary angiographic followup and clinical followup were conducted at more than 8 months and at 12 months after ZES implantation, respectively. Minor and major bleeding events, stent thrombosis (ST), and major adverse cardiac events (MACE) (death, myocardial infarction, cerebrovascular accident, target lesion revascularization, and target vessel revascularization) were evaluated. There were no statistically significant differences in the incidences of ST and MACE between the two groups. The incidence of bleeding events was significantly lower in the 3-month group than in the 12-month group (1.5% versus 11.5%, P < 0.05). DAPT can be safely discontinued at 3 months after ZES implantation, which reduces bleeding risk.

    DOI: 10.1155/2013/518968

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  • Catheter ablation of three macroreentrant atrial tachycardias after surgical repair of double-outlet right ventricle Reviewed

    Tadashi Wada, Atsuyuki Watanabe, Yuji Koide, Kenzo Kagawa, Yoichiro Naito, Sho Tsushima, Hironobu Toda, Satoshi Kawada, Ritsuko Terasaka, Makoto Nakahama, Satoshi Nagase

    Journal of Arrhythmia   28 ( 3 )   196 - 201   2012

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    A 54-year-old man with a surgically repaired double-outlet right ventricle (DORV) presented with palpitations and worsening right heart failure. His 12-lead ECG showed atrial tachycardia (AT) with an atrial cycle length (CL) of 300 ms and an inverted saw-tooth F-wave pattern in the inferior leads II, III, and aVF typical of atrial flutter. Electrophysiological study and radiofrequency catheter ablation were performed. A total of 3 sustained ATs (AT1-AT3) were induced. Using the electroanatomical mapping system, CARTO3, and conventional mapping techniques, the ATs were identified as macroreentrant tachycardias circling around an incisional line on the free wall of the right atrium (AT1), the tricuspid annulus (AT2), and low voltage area in the lateral wall including the right septum (AT3). Accuracy of CARTO3 in three-dimensional reconstruction was sufficient to elucidate anatomical features (including catheter sites, incision, and low voltage areas) and macroreentrant circuits. However, conventional mapping techniques were also necessary to identify the mechanism of the tachycardias, and therefore to eliminate all of them successfully. This case demonstrates that the use of combined conventional and electroanatomical mapping techniques, such as CARTO3, can be helpful in identifying the critical isthmus for catheter ablation of macroreentrant AT in patients with surgically corrected congenital heart disease (CHD). © 2012 Japanese Heart Rhythm Society. Published by Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.joa.2012.01.004

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  • The Usefulness of a Left Ventricular Dyssynchrony Evaluation Using Three-Dimensional Echocardiography in Patients with Narrow QRS Complexes Reviewed

    Atsuyuki Watanabe, Tadashi Wada, Satoshi Kawada, Yuji Koide, Kenzo kagawa, Sho Tushima, Hironobu Toda, Ritsuko Terasaka, Makoto Nakahama

    journal of arrhythmia   27 ( 4 )   206   2011

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    Background: Cardiac resynchronization therapy (CRT) is effective in many symptomatic patients with wide QRS complexes. However, whether CRT is effective in patients with narrow QRS complexes and dyssynchrony is unknown. We evaluated the efficacy of CRT in patients with narrow QRS complexes who were evaluated using real time three-dimensional echocardiography (RT3DE) before the implant. Method and Results: In a total of 18 out of 34 patients, we evaluated the mechanical dyssynchrony using 2D echocardiography and RT3DE. LV dyssynchrony was defined as a standard deviation of the time to reach the minimum systolic volume in 16 LV segments, expressed as the percentage of the cardiac cycle (systolic dyssynchrony index, SDI). A positive response to CRT was defined as a persistent reduction in the NYHA class during the long-term follow-up. An SDI score in the upper 10% was positive. Fourteen of 18 patients (78%) were responders. Six of 14 patients had narrow QRS complexes (QRS duration &lt
    130ms). There was no significant difference in the SDI before the CRT implantation between the patients with narrow or wide QRS complexes (SDI: narrow 11.9±4.1% vs. wide 8.9±3.8%, p=0.09). Conclusion: The evaluation of the dyssynchrony using RT3DE might be useful to decide indication for CRT in patients with a narrow QRS complex. © 2011, Japanese Heart Rhythm Society. All rights reserved.

    DOI: 10.4020/jhrs.27.OP15_2

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  • A Case of J-Wave Syndrome, That Was Suggested to Be Related to the Autonomic Tone Reviewed

    Tadashi Wada, Atsuyuki Watanabe, Yuji Koide, Yoichiro Naito, Kenzo Kagawa, Sho Tsushima, Hironobu Toda, Satoshi Kawada, Ritsuko Terasaka, Makoto Nakahama

    journal of arrhythmia   27 ( 4 )   232   2011

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    We describe a case of a ventricular fibrillation (VF) storm related to a prominent and widely distributed J-wave. A 34-year-old man, without any family history of sudden cardiac death or structural heart disease, suffered from a VF storm unresponsive to repeated defibrillation attempts and drugs including amiodarone. After the VF disappeared, his electrocardiogram (ECG) exhibited prominent J-waves and ST-segment elevation in almost all the leads. The J-point elevation slowly decreased without any recurrence of VF within a few days, and finally the J-waves remained only in the inferolateral leads. In the electrophysiological study, we tried to record an epicardial electrogram from the coronary sinus on the lateral wall, but no definite delayed potentials were observed. After implanting an implantable cardioverter-defibrillator, we performed pharmacologic stress tests (pilsicainide, protanol, mexan and atropine). The J-waves increased only during bradycardia after administering mexan. In the Holter ECG, transient ST-segment elevation was repetitively observed only while asleep.With the J-wave syndrome, it has been suggested that autonomic tone plays a major role in the J-wave variability. In this case, prominent J-waves and ST-segment elevation were observed during bradycardia and sleep. This is a very rare case of J-wave syndrome with transient J-wave changes suggesting some relationship to the autonomic tone. © 2011, Japanese Heart Rhythm Society. All rights reserved.

    DOI: 10.4020/jhrs.27.PJ1_089

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  • Effect of Alternative Pacing Sites between the Right Ventricular Apex and Septum in Heart Failure with a Preserved Ejection Fraction Reviewed

    Tadashi Wada, Atsuyuki Watanabe, Satoshi Kawada, Yuji Koide, Yoichiro Naito, Kenzo Kagawa, Sho Tsushima, Hironobu Toda, Ritsuko Terasaka, Makoto Nakahama

    journal of arrhythmia   27 ( 4 )   294   2011

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    Background: To examine the effect of pacing sites on heart failure, we evaluated the brain natriuretic peptide (BNP) level and hospitalizations for heart failure. Methods: A total of 90 patients (mean age 77±9 years, 43 men) with newly implanted pacemakers (sick sinus syndrome, n = 21
    atrioventricular block, n = 69) were divided into two groups according to the pacing site: RV apical pacing group (RVA group, n = 46) and RV septal pacing group (RVS group, n = 44). All patients had a preserved LV function and more than a 90% cumulative percent ventricular pacing. We performed BNP measurements annually and at the clinical follow-ups (mean duration 3.0 years). Results: Compared with the RVS group, in the RVA group the QRS duration was prolonged (162±14ms vs. 147± 17ms, p&lt
    0.05). However, there was no significant difference in the BNP levels at 1 year (141±141pg/mL vs. 119±139pg/mL, p=NS) and δ BNP, the difference in the BNP levels between post-implantation and 1 year (-29 ±103pg/mL vs. 0±107pg/mL, p=NS). For hospitalization for heart failure, there was no significant difference between the groups (4.4% vs. 6.8%, p=NS). Conclusions: In patients with a preserved LV function, RVS or RVA pacing sites might not correlate with the heart failure. © 2011, Japanese Heart Rhythm Society. All rights reserved.

    DOI: 10.4020/jhrs.27.PJ2_032

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  • 心筋虚血に関連する持続性多形性心室頻拍に対し集学的治療を行った末期腎不全の1例

    藤本竜平, 森田宏, 森田宏, 西本貴史, 松尾直昭, 宮本真和, 戸田洋伸, 川田哲史, 中川晃志, 西井伸洋, 西井伸洋, 伊藤浩

    日本集中治療医学会学術集会(Web)   48th   2021

  • Clinical Significance of Total Vascular Resistance, Augmention Index and Augmentation Pressure in Patients With Peripheral Artery Disease

    Rika Takemoto, Haruhito A. Uchida, Nozomu Otaka, Shugo Okamoto, Mariko Nishiwaki, Yasuhiro Onishi, Natsumi Matsuoka, Yoshiko Hada, Hironobu Toda, Fumio Otsuka, Hiroshi Ito, Jun Wada

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   40   2020.5

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  • Total Vascular Resistance and Augmentation Pressure in Patients with Peripheral Artery Disease

    Rika Takemoto, Haruhito A. Uchida, Nozomu Otaka, Yoshiko Hada, Yasuhiro Onishi, Natsumi Matsuoka, Shugo Okamoto, Mariko Nishiwaki, Hironobu Toda, Fumio Otsuka, Hiroshi Ito, Jun Wada

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   39   2019.5

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  • 顕性蛋白尿をきたした腎動脈狭窄症に対するPTRAの腎保護効果についての検討

    戸田 洋伸, 内田 治仁, 竹内 英実, 江尻 健太郎, 大塚 寛昭, 中川 晃志, 渡邊 敦之, 西井 伸洋, 三好 亨, 中村 一文, 森田 宏, 和田 淳, 伊藤 浩

    脈管学   57 ( Suppl. )   S138 - S138   2017.10

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  • 非心臓手術を受ける高齢患者の高感度心筋troponin T評価で認められた拡張機能障害は周術期心筋損傷のリスクである(Diastolic Dysfunction is a Risk for Perioperative Myocardial Injury Assessed by High-sensitivity Cardiac Troponin T in Elderly Patients Undergoing Non-cardiac Surgery)

    内藤 洋一郎, 増田 拓郎, 幡中 邦彦, 藤尾 栄起, 向原 直木, 戸田 洋伸, 中村 一文, 三好 亨, 中川 晃志, 渡辺 敦之, 西井 伸洋, 森田 宏, 伊藤 浩

    日本循環器学会学術集会抄録集   81回   PJ - 197   2017.3

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  • Coronary Plaque Erosionが原因と考えられたAMIの1例

    戸田洋伸, 網岡尚史, 吉田雅言, 中川晃志, 渡邉敦之, 三好亨, 西井伸洋, 中村一文, 森田宏, 伊藤浩

    日本循環器学会中国地方会(Web)   110th   CHUGOKU.SHIKOKU110,120 (WEB ONLY)   2017

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  • CLI診療における循環器内科の役割

    戸田洋伸, 江尻健太郎, 中川晃志, 渡邊敦之, 三好亨, 西井伸洋, 中村一文, 森田宏, 伊藤浩, 藤井泰宏, 大澤晋

    日本フットケア学会学術集会プログラム・抄録集   15th   109   2017

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  • 家族性高コレステロール血症を基礎に持つ、下行大動脈狭窄に対してEVTを行った1例

    戸田 洋伸, 吉田 雅言, 中川 晃志, 西井 伸洋, 渡邊 敦之, 中村 一文, 伊藤 浩

    脈管学   56 ( Suppl. )   S207 - S207   2016.10

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  • 狭心症の臨床 狭心症 狭心症の治療 狭心症に対する薬物治療について

    戸田洋伸, 伊藤浩

    日本臨床   74   22‐25   2016.8

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  • 【最新冠動脈疾患学(下)-冠動脈疾患の最新治療戦略-】 狭心症の臨床 狭心症 狭心症の治療 狭心症に対する薬物治療について

    戸田 洋伸, 伊藤 浩

    日本臨床   74 ( 増刊6 最新冠動脈疾患学(下) )   22 - 25   2016.8

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  • 高感度トロポニンTで評価した周術期心筋障害に関する検討 拡張障害は周術期心筋障害のリスクである

    戸田 洋伸, 中村 一文, 中川 晃志, 麻植 浩樹, 渡邊 敦之, 西井 伸洋, 三好 亨, 森田 宏, 伊藤 浩

    日本心血管インターベンション治療学会抄録集   25回   MP315 - MP315   2016.7

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  • 冠動脈疾患の治療 薬物療法 βブロッカー

    戸田洋伸, 伊藤浩

    日本臨床   74   581‐585   2016.6

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  • 【最新冠動脈疾患学(上)-冠動脈疾患の最新治療戦略-】 冠動脈疾患の治療 薬物療法 βブロッカー

    戸田 洋伸, 伊藤 浩

    日本臨床   74 ( 増刊4 最新冠動脈疾患学(上) )   581 - 585   2016.6

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  • 血管炎をbaseにした進行性の腎動脈狭窄に対して血管内治療を施行した1例

    戸田洋伸, 江尻健太郎, 中川晃志, 渡邊敦之, 三好亨, 西井伸洋, 中村一文, 森田宏, 伊藤浩

    日本循環器学会中国地方会(Web)   109th   CHUGOKU109,77 (WEB ONLY)   2016

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  • 家族性高コレステロール血症を基礎に持つ,下行大動脈狭窄に対してEVTを行った1例

    戸田洋伸, 吉田雅言, 中川晃志, 西井伸洋, 渡邊敦之, 中村一文, 伊藤浩

    脈管学(Web)   56 ( supplement )   S207(J‐STAGE)   2016

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  • β遮断薬はこう使いこなせ―基本の理解と処方tips―12 周術期の使い方

    戸田洋伸, 伊藤浩

    Heart View   19 ( 13 )   1410 - 1415   2015.12

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  • 【β遮断薬はこう使いこなせ-基本の理解と処方tips-】 治す 周術期の使い方

    戸田 洋伸, 伊藤 浩

    Heart View   19 ( 13 )   1410 - 1415   2015.12

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  • 下肢動脈血栓塞栓症に対するEVTと外科的血栓除去の選択について

    戸田 洋伸, 江尻 健太郎, 大澤 晋, 藤井 泰宏, 武本 梨佳, 内田 治仁, 中村 一文, 伊藤 浩

    脈管学   55 ( Suppl. )   S216 - S216   2015.10

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  • 他疾患を持つ患者さんの看護ケア―糖尿病・認知症・CKD・がん―7 担がん患者と循環器疾患:周術期管理とDVT

    戸田洋伸, 伊藤浩

    循環器ナーシング   5 ( 7 )   66 - 76   2015.7

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  • 【他疾患を持つ患者さんの看護ケア-糖尿病・認知症・CKD・がん-】 担がん患者と循環器疾患 周術期管理とDVT

    戸田 洋伸, 伊藤 浩

    循環器ナーシング   5 ( 7 )   66 - 76   2015.7

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    <point>●周術期心筋梗塞はいかにして生じるか、理解する!●周術期心筋梗塞のハイリスク患者に対する管理について理解する!●DVTの予防と治療を理解する!(著者抄録)

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    Other Link: http://search.jamas.or.jp/link/ui/2015288904

  • 心臓再同期療法(CRT)により心機能の改善を得た修正大血管転位の3例

    戸田 洋伸, 西井 伸洋, 中川 晃志, 永瀬 聡, 森田 宏, 伊藤 浩, 笠原 真吾, 赤木 禎治, 佐野 俊二

    日本成人先天性心疾患学会雑誌   4 ( 1 )   154 - 154   2015.1

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  • 心臓再同期療法(CRT)により心機能の改善を得た修正大血管転位の3例

    戸田洋伸, 西井伸洋, 中川晃志, 永瀬聡, 森田宏, 伊藤浩, 笠原真吾, 赤木禎治, 佐野俊二

    日本成人先天性心疾患学会雑誌(Web)   4 ( 1 )   P7-4 (WEB ONLY)   2015.1

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  • 下肢動脈血栓塞栓症に対するEVTと外科的血栓除去の選択について

    戸田洋伸, 江尻健太郎, 大澤晋, 藤井泰宏, 武本梨佳, 内田治仁, 中村一文, 伊藤浩

    脈管学(Web)   55 ( supplement )   S216(J‐STAGE)   2015

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  • 膝窩動脈外膜嚢腫の一例

    枝木大治, 大澤晋, 藤井泰宏, 戸田洋伸, 増田善逸, 黒子洋介, 小谷恭弘, 小林純子, 衛藤弘城, 堀尾直裕, 新井禎彦, 笠原真悟, 逢坂大樹, 武本梨佳, 佐野俊二

    日本循環器学会中国地方会(Web)   107th   2015

  • A Case of Cardiac Sarcoidosis with Acute Heart Failure Successfully Treated with Steroid Pulse Therapy

    Tomonari Kimura, Kazufumi Nakamura, Koji Tokioka, Toshihiro Sarashina, Hironobu Toda, Yoko Noda, Hiroshi Ito

    JOURNAL OF CARDIAC FAILURE   20 ( 10 )   S206 - S206   2014.10

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  • 繰り返す失神を主訴とする右腕頭動脈狭窄に対して血管内治療を施行した1例

    戸田洋伸, 河合勇介, 江尻健太郎, 山中俊明, 中川晃志, 麻植浩樹, 赤木達, 吉田賢司, 杉山洋樹, 谷山真規子, 三好亨, 西井伸洋, 永瀬聡, 河野晋久, 中村一文, 森田宏, 伊藤浩

    日本循環器学会中国地方会(Web)   105th   CHUGOKU105,72 (WEB ONLY)   2014

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  • 幼少時に心室細動にて蘇生歴があり,挙児希望のある女性に対する治療方針は?

    戸田洋伸, 森田宏, 中川晃志, 赤木達, 河合勇介, 杉山洋樹, 吉田賢司, 麻植浩樹, 谷山真規子, 三好亨, 西井伸洋, 永瀬聡, 河野晋久, 中村一文, 伊藤浩, 平松茂樹

    日本循環器学会中国地方会(Web)   104th   CHUGOKU.SHIKOKU104,63 (WEB ONLY)   2014

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  • Increased Passive Stiffness of Cardiomyocytes in the Transverse Direction and Residual Actin and Myosin Cross-bridge Formation in Hypertrophied Rat Hearts

    Kazufumi Nakamura, Hironobu Toda, Toru Miyoshi, Hiroshi Ito

    JOURNAL OF CARDIAC FAILURE   19 ( 10 )   S121 - S121   2013.10

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  • うっ血性心不全に対するトルバプタンの効果予測因子に関する検討

    戸田洋伸, 中村一文, 渡邊敦之, 中濱一, 寺坂律子, 草野研吾, 伊藤浩

    日本心臓病学会誌   8 ( Supplement 1 )   299 - 299   2013.9

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  • うっ血性心不全に対するトルバプタンの効果予測因子に関する検討

    戸田 洋伸, 中村 一文, 渡邊 敦之, 中濱 一, 寺坂 律子, 草野 研吾, 伊藤 浩

    日本心臓病学会誌   8 ( Suppl.I )   299 - 299   2013.9

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  • 濃厚な家族歴を有し,神経疾患及び冠攣縮性狭心症を合併したProgressive Cardiac Conduction Diseaseの1例

    戸田洋伸, 森田宏, 杉山洋樹, 中川晃志, 麻植浩樹, 谷山真規子, 三好亨, 西井伸洋, 永瀬聡, 河野晋久, 中村一文, 伊藤浩

    日本循環器学会中国地方会(Web)   103rd   CHUGOKU103,60 (WEB ONLY)   2013

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  • うっ血性心不全に対するトルバプタンの効果予測因子に関する検討

    戸田洋伸, 中村一文, 杉山洋樹, 中川晃志, 麻植浩樹, 谷山真規子, 三好亨, 西井伸洋, 永瀬聡, 河野晋久, 森田宏, 伊藤浩, 中濱一

    日本循環器学会中国地方会(Web)   103rd ( Suppl.I )   CHUGOKU103,110 (WEB ONLY) - 299   2013

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  • 大腿動脈穿刺部に感染性動脈瘤を形成し,敗血症から総腸骨動脈ステント周囲膿瘍,さらに総腸骨静脈穿破を来した1例

    戸田洋伸, 中濱一, 小出祐嗣, 香川健三, 内藤洋一郎, 津島翔, 川田哲史, 和田匡史, 渡邊敦之, 寺坂律子, 栗山充仁, 田邊敦, 喜岡幸央

    広島医学   65 ( 1 )   53   2012.1

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  • 大腿動脈穿刺部に感染性動脈瘤を形成し、敗血症から総腸骨動脈ステント周囲膿瘍、さらに総腸骨静脈穿破を来した1例

    戸田 洋伸, 中濱 一, 小出 祐嗣, 香川 健三, 内藤 洋一郎, 津島 翔, 川田 哲史, 和田 匡史, 渡邊 敦之, 寺坂 律子, 栗山 充仁, 田邊 敦, 喜岡 幸央

    広島医学   65 ( 1 )   53 - 53   2012.1

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  • トルバプタンが奏効した拡張型心筋症の1例

    戸田洋伸, 中濱一

    Fluid Manag Renaiss   1 ( 2 )   198 - 201   2011.10

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  • トルバプタンが奏効した拡張型心筋症の1例

    戸田 洋伸, 中濱 一

    Fluid Management Renaissance   1 ( 2 )   198 - 201   2011.10

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    84歳男。拡張型心筋症、慢性心不全で外来通院中で、慢性心不全の増悪にて入退院をくり返した。呼吸困難が悪化したため救急車にて搬送となった。拡張型心筋症を基礎心疾患とした慢性心不全の増悪と診断した。入院後、内服利尿薬は継続し、トルバプタンを追加した。投与開始4時間後から250mL/時を超える利尿が得られた。投与開始16時間後、血清Na濃度が増加し、口渇の訴えも認めたため飲水制限を緩和した。投与2日目には5330mL/日と著明な利尿が得られ、心不全徴候も改善したため飲水制限を中止とし、5%ブドウ糖液の点滴を追加した。投与7日目の胸部レントゲンにて、うっ血および心拡大の改善を認めた。投与11日目に軽快退院した。退院後トルバプタンを2週間だけ継続したが、中止1ヵ月後の外来受診時に心不全の増悪を認めたためフロセミドを増量した。現在まで心不全増悪による入院には至っていないが、血清Crが上昇傾向にある。

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  • The Number of Leads of Abnormal Q Waves is a Predictive Factor for Aggravation of Takotsubo Cardiomyopathy

    Hironobu Toda, Makoto Nakahama, Yuji Koide, Kenzo Kagawa, Youichirou Naito, Shyou Tsushima, Satoshi Kawada, Tadashi Wada, Atsuyuki Watanabe, Ritsuko Terasaka

    JOURNAL OF CARDIAC FAILURE   17 ( 9 )   S172 - S172   2011.9

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  • 浅大腿動脈病変に対する血管内治療後の中期成績および再狭窄症例の検討

    戸田洋伸, 中濱一, 小出祐嗣, 池田昌絵, 和田匡史, 渡邊敦之, 橋本克史, 寺坂律子

    広島医学   64 ( 4 )   220 - 221   2011.4

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  • NICORANDIL FURTHER IMPROVE MICROVASCULAR FUNCTION IN PATIENTS WITH STEMI UNDERGOING ANTI-EMBOLIC THERAPY

    Yusuke Kawai, Hironobu Toda, Atsuyuki Watanabe, Katsushi Hashimoto, Makoto Nakahama, Hiroshi Ito

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   57 ( 14 )   E983 - E983   2011.4

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  • 浅大腿動脈病変に対する血管内治療後の中期成績および再狭窄症例の検討

    戸田 洋伸, 中濱 一, 小出 祐嗣, 池田 昌絵, 和田 匡史, 渡邊 敦之, 橋本 克史, 寺坂 律子

    広島医学   64 ( 4 )   220 - 221   2011.4

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  • 当院におけるTAXUSステントの使用経験

    戸田洋伸, 山中俊明, 杉山弘恭, 河合勇介, 渡辺敦之, 橋本克史, 寺坂律子, 中濱一, 山田信行

    Circ J   73 ( Supplement 2 )   962   2009.4

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  • 当院におけるTAXUSステントの使用経験

    戸田 洋伸, 山中 俊明, 杉山 弘恭, 河合 勇介, 渡辺 敦之, 橋本 克史, 寺坂 律子, 中濱 一, 山田 信行

    Circulation Journal   73 ( Suppl.II )   962 - 962   2009.4

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  • 高度石灰化を伴う膝窩動脈狭窄に対してRotablator+PTAが有効であった

    戸田洋伸, 中濱一, 山中俊明, 渡辺敦之, 橋本克史, 寺坂律子, 山田信行, 河合勇介

    日本循環器学会中国地方会(Web)   94th   CHUGOKU.SHIKOKU94,88 (WEB ONLY)   2009

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  • ARDSを合併し救命に難渋したたこつぼ型心筋症の1例(当院におけるたこつぼ型心筋症33症例の検討を含む)

    戸田洋伸, 渡辺敦之, 井原弘貴, 池田昌絵, 山中俊明, 和田匡史, 橋本克史, 寺坂律子, 中濱一, 山田信行

    日本循環器学会中国地方会(Web)   95th   CHUGOKU95,131 (WEB ONLY)   2009

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  • MS‐CTにて診断し得た急性下壁梗塞の一例

    戸田洋伸, 前川清明, 櫻井元子, 川本健治, 福家聡一郎, 齋藤博則, 佐藤哲也, 飛岡徹

    Circ J   70 ( Supplement 2 )   1066 - 1066   2006.4

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  • MS-CTにて診断し得た急性下壁梗塞の一例

    戸田 洋伸, 前川 清明, 櫻井 元子, 川本 健治, 福家 聡一郎, 齋藤 博則, 佐藤 哲也, 飛岡 徹

    Circulation Journal   70 ( Suppl.II )   1066 - 1066   2006.4

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Research Projects

  • 閉塞性動脈硬化症患者に対するレジスタンストレーニングを組み合わせた運動療法の開発

    Grant number:21K16088  2021.04 - 2023.03

    日本学術振興会  科学研究費助成事業 若手研究  若手研究

    戸田 洋伸

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    Grant amount:\4550000 ( Direct expense: \3500000 、 Indirect expense:\1050000 )

    本研究では、間欠性跛行を有するPAD患者に対して、レジスタンストレーニングと歩行訓練を組み合わせた新しい運動療法を実施することにより、歩行機能・下肢筋力量・下肢血流量を含めた下肢機能がどのように変化するかを明らかにし、①レジスタンストレーニングを組み合わせた新しい運動療法施行群と、②従来の血行再建術+在宅運動療法を行う群の2群を比較することで、新しい運動療法の有効性・安全性を検証する。本研究は、2段階の研究を実施しており、STEP①単施設前向き探索的介入試験(単一群試験)、STEP②多施設無作為化並行群間比較試験に分けて、上記課題に対して検討を行う。
    <BR>
    STEP①単施設前向き探索的介入試験(単一群試験) 研究対象:間欠性跛行を訴える 大腿膝窩動脈病変を有するPAD症例 目標症例数:20例 主要評価項目:運動療法6か月後の下肢機能の変化 副次評価項目:足関節/上腕血圧比(ABI)の変化、跛行症状およびQOLに関する質問票(WIQ、Euro QOL)、心血管イベント(死亡、心筋梗塞、脳卒中、血行再建術)の有無
    <BR>
    現在、1段階目の単施設前向き探索的介入研究を実施中です。岡山大学病院における、間欠性跛行を訴える大腿膝窩動脈病変を有するPAD症例に対して、20例の登録を予定しており、現在、症例の登録段階です。生理検査室にて、各種検査を実施し、レジスタンストレーニングは心臓リハビリテーション外来にて実施を行っている状況です。

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Class subject in charge

  • Cardiovascular Medicine(Core Clinical Practice) (2023academic year) special  - その他

  • Cadiovascular Disease (2023academic year) special  - その他

  • Cardiovascular Medicine(Core Clinical Practice) (2022academic year) special  - その他

  • Cadiovascular Disease (2022academic year) special  - その他

  • Lecture: Myocardial Infarction (2022academic year) special  - その他

  • Cardiovascular Medicine(Core Clinical Practice) (2021academic year) special  - その他

  • Cadiovascular Disease (2021academic year) special  - その他

  • Lecture: Myocardial Infarction (2021academic year) special  - その他

  • Cardiovascular Medicine(Core Clinical Practice) (2020academic year) special  - その他

  • Cadiovascular Disease (2020academic year) special  - その他

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