Faculty Profiles - HIGUCHI Chigusa

Papers - HIGUCHI Chigusa

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Plasma angiotensin-converting enzyme 2 (ACE2) is a marker for renal outcome of diabetic kidney disease (DKD) (U-CARE study 3). Reviewed International journal

Asami Ueno, Yasuhiro Onishi, Koki Mise, Satoshi Yamaguchi, Ayaka Kanno, Ichiro Nojima, Chigusa Higuchi, Haruhito A Uchida, Kenichi Shikata, Satoshi Miyamoto, Atsuko Nakatsuka, Jun Eguchi, Kazuyuki Hida, Akihiro Katayama, Mayu Watanabe, Tatsuaki Nakato, Atsuhito Tone, Sanae Teshigawara, Takashi Matsuoka, Shinji Kamei, Kazutoshi Murakami, Ikki Shimizu, Katsuhito Miyashita, Shinichiro Ando, Tomokazu Nunoue, Jun Wada

BMJ open diabetes research & care 12 ( 3 ) 2024.5

Language：English Publishing type：Research paper (scientific journal)

INTRODUCTION: ACE cleaves angiotensin I (Ang I) to angiotensin II (Ang II) inducing vasoconstriction via Ang II type 1 (AT1) receptor, while ACE2 cleaves Ang II to Ang (1-7) causing vasodilatation by acting on the Mas receptor. In diabetic kidney disease (DKD), it is still unclear whether plasma or urine ACE2 levels predict renal outcomes or not. RESEARCH DESIGN AND METHODS: Among 777 participants with diabetes enrolled in the Urinary biomarker for Continuous And Rapid progression of diabetic nEphropathy study, the 296 patients followed up for 9 years were investigated. Plasma and urinary ACE2 levels were measured by the ELISA. The primary end point was a composite of a decrease of estimated glomerular filtration rate (eGFR) by at least 30% from baseline or initiation of hemodialysis or peritoneal dialysis. The secondary end points were a 30% increase or a 30% decrease in albumin-to-creatinine ratio from baseline to 1 year. RESULTS: The cumulative incidence of the renal composite outcome was significantly higher in group 1 with lowest tertile of plasma ACE2 (p=0.040). Group 2 with middle and highest tertile was associated with better renal outcomes in the crude Cox regression model adjusted by age and sex (HR 0.56, 95% CI 0.31 to 0.99, p=0.047). Plasma ACE2 levels demonstrated a significant association with 30% decrease in ACR (OR 1.46, 95% CI 1.044 to 2.035, p=0.027) after adjusting for age, sex, systolic blood pressure, hemoglobin A1c, and eGFR. CONCLUSIONS: Higher baseline plasma ACE2 levels in DKD were protective for development and progression of albuminuria and associated with fewer renal end points, suggesting plasma ACE2 may be used as a prognosis marker of DKD. TRIAL REGISTRATION NUMBER: UMIN000011525.

DOI： 10.1136/bmjdrc-2024-004237

PubMed

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岡山大学におけるHPVワクチン接種希望に関するアンケート調査

樋口千草, 小川千加子, 萩谷英大, 大塚勇輝, 大塚文男, 影山真希, 成田美香, 岡香織, 黒木清美, 河原宏子, 宮道力, 岡部伸幸, 大西勝, 岩﨑良章

CAMPUS HEALTH 61 ( 1 ) 2024.3

岡山大学における幸福度の検討～ダイバーシティに関するアンケートより～

樋口千草, 片岡仁美, 中谷文美, 池谷航介, 成田美香, 岡香織, 黒木清美, 河原宏子, 宮道力, 岡部伸幸, 大西勝, 岩﨑良章

CAMPUS HEALTH 61 ( 1 ) 2024.3

Effects of empagliflozin on progression of chronic kidney disease: a prespecified secondary analysis from the empa-kidney trial Reviewed

N Staplin, R Haynes, PK Judge, C Wanner, JB Green, J Emberson, D Preiss, KJ Mayne, SYA Ng, E Sammons, D Zhu, M Hill, W Stevens, K Wallendszus, S Brenner, AK Cheung, ZH Liu, J Li, LS Hooi, WJ Liu, T Kadowaki, M Nangaku, A Levin, D Cherney, AP Maggioni, R Pontremoli, R Deo, S Goto, X Rossello, KR Tuttle, D Steubl, M Petrini, S Seidi, MJ Landray, C Baigent, WG Herrington, S Abat, R Abd Rahman, R Abdul Cader, MI Abdul Hafidz, MZ Abdul Wahab, NK Abdullah, T Abdul-Samad, M Abe, N Abraham, S Acheampong, P Achiri, JA Acosta, A Adeleke, V Adell, R Adewuyi-Dalton, N Adnan, A Africano, M Agharazii, F Aguilar, A Aguilera, M Ahmad, MK Ahmad, NA Ahmad, NH Ahmad, NI Ahmad, N Ahmad Miswan, H Ahmad Rosdi, I Ahmed, S Ahmed, S Ahmed, J Aiello, A Aitken, R AitSadi, S Aker, S Akimoto, A Akinfolarin, S Akram, F Alberici, C Albert, L Aldrich, M Alegata, L Alexander, S Alfaress, M Alhadj Ali, A Ali, A Ali, R Alicic, A Aliu, R Almaraz, R Almasarwah, J Almeida, A Aloisi, L Al-Rabadi, D Alscher, P Alvarez, B Al-Zeer, M Amat, C Ambrose, H Ammar, Y An, L Andriaccio, K Ansu, A Apostolidi, N Arai, H Araki, S Araki, A Arbi, O Arechiga, S Armstrong, T Arnold, S Aronoff, W Arriaga, J Arroyo, D Arteaga, S Asahara, A Asai, N Asai, S Asano, M Asawa, MF Asmee, F Aucella, M Augustin, A Avery, A Awad, IY Awang, M Awazawa, A Axler, W Ayub, Z Azhari, R Baccaro, C Badin, B Bagwell, E Bahlmann-Kroll, AZ Bahtar, C Baigent, D Bains, H Bajaj, R Baker, E Baldini, B Banas, D Banerjee, S Banno, S Bansal, S Barberi, S Barnes, C Barnini, C Barot, K Barrett, R Barrios, B Bartolomei Mecatti, I Barton, J Barton, W Basily, S Bavanandan, A Baxter, L Becker, S Beddhu, J Beige, S Beigh, S Bell, U Benck, A Beneat, A Bennett, D Bennett, S Benyon, J Berdeprado, T Bergler, A Bergner, M Berry, M Bevilacqua, J Bhairoo, S Bhandari, N Bhandary, A Bhatt, M Bhattarai, M Bhavsar, W Bian, F Bianchini, S Bianco, R Bilous, J Bilton, D Bilucaglia, C Bird, D Birudaraju, M Biscoveanu, C Blake, N Bleakley, K Bocchicchia, S Bodine, R Bodington, S Boedecker, M Bolduc, S Bolton, C Bond, F Boreky, K Boren, R Bouchi, L Bough, D Bovan, C Bowler, L Bowman, N Brar, C Braun, A Breach, M Breitenfeldt, S Brenner, B Brettschneider, A Brewer, G Brewer, V Brindle, E Brioni, C Brown, H Brown, L Brown, R Brown, S Brown, D Browne, K Bruce, M Brueckmann, N Brunskill, M Bryant, M Brzoska, Y Bu, C Buckman, M Budoff, M Bullen, A Burke, S Burnette, C Burston, M Busch, J Bushnell, S Butler, C Büttner, C Byrne, A Caamano, J Cadorna, C Cafiero, M Cagle, J Cai, K Calabrese, C Calvi, B Camilleri, S Camp, D Campbell, R Campbell, H Cao, I Capelli, M Caple, B Caplin, A Cardone, J Carle, V Carnall, M Caroppo, S Carr, G Carraro, M Carson, P Casares, C Castillo, C Castro, B Caudill, V Cejka, M Ceseri, L Cham, A Chamberlain, J Chambers, CBT Chan, JYM Chan, YC Chan, E Chang, E Chang, T Chant, T Chavagnon, P Chellamuthu, F Chen, J Chen, P Chen, TM Chen, Y Chen, Y Chen, C Cheng, H Cheng, MC Cheng, D Cherney, AK Cheung, CH Ching, N Chitalia, R Choksi, C Chukwu, K Chung, G Cianciolo, L Cipressa, S Clark, H Clarke, R Clarke, S Clarke, B Cleveland, E Cole, H Coles, L Condurache, A Connor, K Convery, A Cooper, N Cooper, Z Cooper, L Cooperman, L Cosgrove, P Coutts, A Cowley, R Craik, G Cui, T Cummins, N Dahl, H Dai, L Dajani, A D'Amelio, E Damian, K Damianik, L Danel, C Daniels, T Daniels, S Darbeau, H Darius, T Dasgupta, J Davies, L Davies, A Davis, J Davis, L Davis, R Dayanandan, S Dayi, R Dayrell, L De Nicola, S Debnath, W Deeb, S Degenhardt, K DeGoursey, M Delaney, R Deo, R DeRaad, V Derebail, D Dev, M Devaux, P Dhall, G Dhillon, J Dienes, M Dobre, E Doctolero, V Dodds, D Domingo, D Donaldson, P Donaldson, C Donhauser, V Donley, S Dorestin, S Dorey, T Doulton, D Draganova, K Draxlbauer, F Driver, H Du, F Dube, T Duck, T Dugal, J Dugas, H Dukka, H Dumann, W Durham, M Dursch, R Dykas, R Easow, E Eckrich, G Eden, E Edmerson, H Edwards, LW Ee, J Eguchi, Y Ehrl, K Eichstadt, W Eid, B Eilerman, Y Ejima, H Eldon, T Ellam, L Elliott, R Ellison, J Emberson, R Epp, A Er, M Espino-Obrero, S Estcourt, L Estienne, G Evans, J Evans, S Evans, G Fabbri, M Fajardo-Moser, C Falcone, F Fani, P Faria-Shayler, F Farnia, D Farrugia, M Fechter, D Fellowes, F Feng, J Fernandez, P Ferraro, A Field, S Fikry, J Finch, H Finn, P Fioretto, R Fish, A Fleischer, D Fleming-Brown, L Fletcher, R Flora, C Foellinger, N Foligno, S Forest, Z Forghani, K Forsyth, D Fottrell-Gould, P Fox, A Frankel, D Fraser, R Frazier, K Frederick, N Freking, H French, A Froment, B Fuchs, L Fuessl, H Fujii, A Fujimoto, A Fujita, K Fujita, Y Fujita, M Fukagawa, Y Fukao, A Fukasawa, T Fuller, T Funayama, E Fung, M Furukawa, Y Furukawa, M Furusho, S Gabel, J Gaidu, S Gaiser, K Gallo, C Galloway, G Gambaro, CC Gan, C Gangemi, M Gao, K Garcia, M Garcia, C Garofalo, M Garrity, A Garza, S Gasko, M Gavrila, B Gebeyehu, A Geddes, G Gentile, A George, J George, L Gesualdo, F Ghalli, A Ghanem, T Ghate, S Ghavampour, A Ghazi, A Gherman, U Giebeln-Hudnell, B Gill, S Gillham, I Girakossyan, M Girndt, A Giuffrida, M Glenwright, T Glider, R Gloria, D Glowski, BL Goh, CB Goh, T Gohda, R Goldenberg, R Goldfaden, C Goldsmith, B Golson, V Gonce, Q Gong, B Goodenough, N Goodwin, M Goonasekera, A Gordon, J Gordon, A Gore, H Goto, S Goto, S Goto, D Gowen, A Grace, J Graham, G Grandaliano, M Gray, JB Green, T Greene, G Greenwood, B Grewal, R Grifa, D Griffin, S Griffin, P Grimmer, E Grobovaite, S Grotjahn, A Guerini, C Guest, S Gunda, B Guo, Q Guo, S Haack, M Haase, K Haaser, K Habuki, A Hadley, S Hagan, S Hagge, H Haller, S Ham, S Hamal, Y Hamamoto, N Hamano, M Hamm, A Hanburry, M Haneda, C Hanf, W Hanif, J Hansen, L Hanson, S Hantel, T Haraguchi, E Harding, T Harding, C Hardy, C Hartner, Z Harun, L Harvill, A Hasan, H Hase, F Hasegawa, T Hasegawa, A Hashimoto, C Hashimoto, M Hashimoto, S Hashimoto, S Haskett, SJ Hauske, A Hawfield, T Hayami, M Hayashi, S Hayashi, R Haynes, A Hazara, C Healy, J Hecktman, G Heine, H Henderson, R Henschel, A Hepditch, K Herfurth, G Hernandez, A Hernandez Pena, C Hernandez-Cassis, WG Herrington, C Herzog, S Hewins, D Hewitt, L Hichkad, S Higashi, C Higuchi, C Hill, L Hill, M Hill, T Himeno, A Hing, Y Hirakawa, K Hirata, Y Hirota, T Hisatake, S Hitchcock, A Hodakowski, W Hodge, R Hogan, U Hohenstatt, B Hohenstein, L Hooi, S Hope, M Hopley, S Horikawa, D Hosein, T Hosooka, L Hou, W Hou, L Howie, A Howson, M Hozak, Z Htet, X Hu, Y Hu, J Huang, N Huda, L Hudig, A Hudson, C Hugo, R Hull, L Hume, W Hundei, N Hunt, A Hunter, S Hurley, A Hurst, C Hutchinson, T Hyo, FH Ibrahim, S Ibrahim, N Ihana, T Ikeda, A Imai, R Imamine, A Inamori, H Inazawa, J Ingell, K Inomata, Y Inukai, M Ioka, A Irtiza-Ali, T Isakova, W Isari, M Iselt, A Ishiguro, K Ishihara, T Ishikawa, T Ishimoto, K Ishizuka, R Ismail, S Itano, H Ito, K Ito, M Ito, Y Ito, S Iwagaitsu, Y Iwaita, T Iwakura, M Iwamoto, M Iwasa, H Iwasaki, S Iwasaki, K Izumi, K Izumi, T Izumi, SM Jaafar, C Jackson, Y Jackson, G Jafari, M Jahangiriesmaili, N Jain, K Jansson, H Jasim, L Jeffers, A Jenkins, M Jesky, J Jesus-Silva, D Jeyarajah, Y Jiang, X Jiao, G Jimenez, B Jin, Q Jin, J Jochims, B Johns, C Johnson, T Johnson, S Jolly, L Jones, L Jones, S Jones, T Jones, V Jones, M Joseph, S Joshi, P Judge, N Junejo, S Junus, M Kachele, T Kadowaki, H Kadoya, H Kaga, H Kai, H Kajio, W Kaluza-Schilling, L Kamaruzaman, A Kamarzarian, Y Kamimura, H Kamiya, C Kamundi, T Kan, Y Kanaguchi, A Kanazawa, E Kanda, S Kanegae, K Kaneko, K Kaneko, HY Kang, T Kano, M Karim, D Karounos, W Karsan, R Kasagi, N Kashihara, H Katagiri, A Katanosaka, A Katayama, M Katayama, E Katiman, K Kato, M Kato, N Kato, S Kato, T Kato, Y Kato, Y Katsuda, T Katsuno, J Kaufeld, Y Kavak, I Kawai, M Kawai, M Kawai, A Kawase, S Kawashima, A Kazory, J Kearney, B Keith, J Kellett, S Kelley, M Kershaw, M Ketteler, Q Khai, Q Khairullah, H Khandwala, KKL Khoo, A Khwaja, K Kidokoro, J Kielstein, M Kihara, C Kimber, S Kimura, H Kinashi, H Kingston, M Kinomura, E Kinsella-Perks, M Kitagawa, M Kitajima, S Kitamura, A Kiyosue, M Kiyota, F Klauser, G Klausmann, W Kmietschak, K Knapp, C Knight, A Knoppe, C Knott, M Kobayashi, R Kobayashi, T Kobayashi, M Koch, S Kodama, N Kodani, E Kogure, M Koizumi, H Kojima, T Kojo, N Kolhe, H Komaba, T Komiya, H Komori, SP Kon, M Kondo, M Kondo, W Kong, M Konishi, K Kono, M Koshino, T Kosugi, B Kothapalli, T Kozlowski, B Kraemer, A Kraemer-Guth, J Krappe, D Kraus, C Kriatselis, C Krieger, P Krish, B Kruger, KR Ku Md Razi, Y Kuan, S Kubota, S Kuhn, P Kumar, S Kume, I Kummer, R Kumuji, A Küpper, T Kuramae, L Kurian, C Kuribayashi, R Kurien, E Kuroda, T Kurose, A Kutschat, N Kuwabara, H Kuwata, G La Manna, M Lacey, K Lafferty, P LaFleur, V Lai, E Laity, A Lambert, MJ Landray, M Langlois, F Latif, E Latore, E Laundy, D Laurienti, A Lawson, M Lay, I Leal, I Leal, AK Lee, J Lee, KQ Lee, R Lee, SA Lee, YY Lee, Y Lee-Barkey, N Leonard, G Leoncini, CM Leong, S Lerario, A Leslie, A Levin, A Lewington, J Li, N Li, X Li, Y Li, L Liberti, ME Liberti, A Liew, YF Liew, U Lilavivat, SK Lim, YS Lim, E Limon, H Lin, E Lioudaki, H Liu, J Liu, L Liu, Q Liu, WJ Liu, X Liu, Z Liu, D Loader, H Lochhead, CL Loh, A Lorimer, L Loudermilk, J Loutan, CK Low, CL Low, YM Low, Z Lozon, Y Lu, D Lucci, U Ludwig, N Luker, D Lund, R Lustig, S Lyle, C Macdonald, I MacDougall, R Machicado, D MacLean, P Macleod, A Madera, F Madore, K Maeda, H Maegawa, S Maeno, M Mafham, J Magee, AP Maggioni, DY Mah, V Mahabadi, M Maiguma, Y Makita, G Makos, L Manco, R Mangiacapra, J Manley, P Mann, S Mano, G Marcotte, J Maris, P Mark, S Markau, M Markovic, C Marshall, M Martin, C Martinez, S Martinez, G Martins, K Maruyama, S Maruyama, K Marx, A Maselli, A Masengu, A Maskill, S Masumoto, K Masutani, M Matsumoto, T Matsunaga, N Matsuoka, M Matsushita, M Matthews, S Matthias, E Matvienko, M Maurer, P Maxwell, KJ Mayne, N Mazlan, SA Mazlan, A Mbuyisa, K McCafferty, F McCarroll, T McCarthy, C McClary-Wright, K McCray, P McDermott, C McDonald, R McDougall, E McHaffie, K McIntosh, T McKinley, S McLaughlin, N McLean, L McNeil, A Measor, J Meek, A Mehta, R Mehta, M Melandri, P Mené, T Meng, J Menne, K Merritt, S Merscher, C Meshykhi, P Messa, L Messinger, N Miftari, R Miller, Y Miller, E Miller-Hodges, M Minatoguchi, M Miners, R Minutolo, T Mita, Y Miura, M Miyaji, S Miyamoto, T Miyatsuka, M Miyazaki, I Miyazawa, R Mizumachi, M Mizuno, S Moffat, FS Mohamad Nor, SN Mohamad Zaini, FA Mohamed Affandi, C Mohandas, R Mohd, NA Mohd Fauzi, NH Mohd Sharif, Y Mohd Yusoff, L Moist, A Moncada, M Montasser, A Moon, C Moran, N Morgan, J Moriarty, G Morig, H Morinaga, K Morino, T Morisaki, Y Morishita, S Morlok, A Morris, F Morris, S Mostafa, Y Mostefai, M Motegi, N Motherwell, D Motta, A Mottl, R Moys, S Mozaffari, J Muir, J Mulhern, S Mulligan, Y Munakata, C Murakami, M Murakoshi, A Murawska, K Murphy, L Murphy, S Murray, H Murtagh, MA Musa, L Mushahar, R Mustafa, R Mustafar, M Muto, E Nadar, R Nagano, T Nagasawa, E Nagashima, H Nagasu, S Nagelberg, H Nair, Y Nakagawa, M Nakahara, J Nakamura, R Nakamura, T Nakamura, M Nakaoka, E Nakashima, J Nakata, M Nakata, S Nakatani, A Nakatsuka, Y Nakayama, G Nakhoul, M Nangaku, G Naverrete, A Navivala, I Nazeer, L Negrea, C Nethaji, E Newman, SYA Ng, TJ Ng, LLS Ngu, T Nimbkar, H Nishi, M Nishi, S Nishi, Y Nishida, A Nishiyama, J Niu, P Niu, G Nobili, N Nohara, I Nojima, J Nolan, H Nosseir, M Nozawa, M Nunn, S Nunokawa, M Oda, M Oe, Y Oe, K Ogane, W Ogawa, T Ogihara, G Oguchi, M Ohsugi, K Oishi, Y Okada, J Okajyo, S Okamoto, K Okamura, O Olufuwa, R Oluyombo, A Omata, Y Omori, LM Ong, YC Ong, J Onyema, A Oomatia, A Oommen, R Oremus, Y Orimo, V Ortalda, Y Osaki, Y Osawa, J Osmond Foster, A O'Sullivan, T Otani, N Othman, S Otomo, J O'Toole, L Owen, T Ozawa, A Padiyar, N Page, S Pajak, A Paliege, A Pandey, R Pandey, H Pariani, J Park, M Parrigon, J Passauer, M Patecki, M Patel, R Patel, T Patel, Z Patel, R Paul, R Paul, L Paulsen, L Pavone, A Peixoto, J Peji, BC Peng, K Peng, L Pennino, E Pereira, E Perez, P Pergola, F Pesce, G Pessolano, W Petchey, EJ Petr, T Pfab, P Phelan, R Phillips, T Phillips, M Phipps, G Piccinni, T Pickett, S Pickworth, M Piemontese, D Pinto, J Piper, J Plummer-Morgan, D Poehler, L Polese, V Poma, R Pontremoli, A Postal, C Pötz, A Power, N Pradhan, R Pradhan, D Preiss, E Preiss, K Preston, N Prib, L Price, C Provenzano, C Pugay, R Pulido, F Putz, Y Qiao, R Quartagno, M Quashie-Akponeware, R Rabara, R Rabasa-Lhoret, D Radhakrishnan, M Radley, R Raff, S Raguwaran, F Rahbari-Oskoui, M Rahman, K Rahmat, S Ramadoss, S Ramanaidu, S Ramasamy, R Ramli, S Ramli, T Ramsey, A Rankin, A Rashidi, L Raymond, WAFA Razali, K Read, H Reiner, A Reisler, C Reith, J Renner, B Rettenmaier, L Richmond, D Rijos, R Rivera, V Rivers, H Robinson, M Rocco, I Rodriguez-Bachiller, R Rodriquez, C Roesch, J Roesch, J Rogers, M Rohnstock, S Rolfsmeier, M Roman, A Romo, A Rosati, S Rosenberg, T Ross, X Rossello, M Roura, M Roussel, S Rovner, S Roy, S Rucker, L Rump, M Ruocco, S Ruse, F Russo, M Russo, M Ryder, A Sabarai, C Saccà, R Sachson, E Sadler, NS Safiee, M Sahani, A Saillant, J Saini, C Saito, S Saito, K Sakaguchi, M Sakai, H Salim, C Salviani, E Sammons, A Sampson, F Samson, P Sandercock, S Sanguila, G Santorelli, D Santoro, N Sarabu, T Saram, R Sardell, H Sasajima, T Sasaki, S Satko, A Sato, D Sato, H Sato, H Sato, J Sato, T Sato, Y Sato, M Satoh, K Sawada, M Schanz, F Scheidemantel, M Schemmelmann, E Schettler, V Schettler, GR Schlieper, C Schmidt, G Schmidt, U Schmidt, H Schmidt-Gurtler, M Schmude, A Schneider, I Schneider, C Schneider-Danwitz, M Schomig, T Schramm, A Schreiber, S Schricker, B Schroppel, L Schulte-Kemna, E Schulz, B Schumacher, A Schuster, A Schwab, F Scolari, A Scott, W Seeger, W Seeger, M Segal, L Seifert, M Seifert, M Sekiya, R Sellars, MR Seman, S Shah, S Shah, L Shainberg, M Shanmuganathan, F Shao, K Sharma, C Sharpe, M Sheikh-Ali, J Sheldon, C Shenton, A Shepherd, M Shepperd, R Sheridan, Z Sheriff, Y Shibata, T Shigehara, K Shikata, K Shimamura, H Shimano, Y Shimizu, H Shimoda, K Shin, G Shivashankar, N Shojima, R Silva, CSB Sim, K Simmons, S Sinha, T Sitter, S Sivanandam, M Skipper, K Sloan, L Sloan, R Smith, J Smyth, T Sobande, M Sobata, S Somalanka, X Song, F Sonntag, B Sood, SY Sor, J Soufer, H Sparks, G Spatoliatore, T Spinola, S Squyres, A Srivastava, J Stanfield, N Staplin, K Staylor, A Steele, O Steen, D Steffl, J Stegbauer, C Stellbrink, E Stellbrink, W Stevens, A Stevenson, V Stewart-Ray, J Stickley, D Stoffler, B Stratmann, S Streitenberger, F Strutz, J Stubbs, J Stumpf, N Suazo, P Suchinda, R Suckling, A Sudin, K Sugamori, H Sugawara, K Sugawara, D Sugimoto, H Sugiyama, H Sugiyama, T Sugiyama, M Sullivan, M Sumi, N Suresh, D Sutton, H Suzuki, R Suzuki, Y Suzuki, Y Suzuki, Y Suzuki, E Swanson, P Swift, S Syed, H Szerlip, M Taal, M Taddeo, C Tailor, K Tajima, M Takagi, K Takahashi, K Takahashi, M Takahashi, T Takahashi, E Takahira, T Takai, M Takaoka, J Takeoka, A Takesada, M Takezawa, M Talbot, J Taliercio, T Talsania, Y Tamori, R Tamura, Y Tamura, CHH Tan, EZZ Tan, A Tanabe, K Tanabe, A Tanaka, A Tanaka, N Tanaka, S Tang, Z Tang, K Tanigaki, M Tarlac, A Tatsuzawa, JF Tay, LL Tay, J Taylor, K Taylor, K Taylor, A Te, L Tenbusch, KS Teng, A Terakawa, J Terry, ZD Tham, S Tholl, G Thomas, KM Thong, D Tietjen, A Timadjer, H Tindall, S Tipper, K Tobin, N Toda, A Tokuyama, M Tolibas, A Tomita, T Tomita, J Tomlinson, L Tonks, J Topf, S Topping, A Torp, A Torres, F Totaro, P Toth, Y Toyonaga, F Tripodi, K Trivedi, E Tropman, D Tschope, J Tse, K Tsuji, S Tsunekawa, R Tsunoda, B Tucky, S Tufail, A Tuffaha, E Turan, H Turner, J Turner, M Turner, KR Tuttle, YL Tye, A Tyler, J Tyler, H Uchi, H Uchida, T Uchida, T Uchida, T Udagawa, S Ueda, Y Ueda, K Ueki, S Ugni, E Ugwu, R Umeno, C Unekawa, K Uozumi, K Urquia, A Valleteau, C Valletta, R van Erp, C Vanhoy, V Varad, R Varma, A Varughese, P Vasquez, A Vasseur, R Veelken, C Velagapudi, K Verdel, S Vettoretti, G Vezzoli, V Vielhauer, R Viera, E Vilar, S Villaruel, L Vinall, J Vinathan, M Visnjic, E Voigt, M von-Eynatten, M Vourvou, J Wada, J Wada, T Wada, Y Wada, K Wakayama, Y Wakita, K Wallendszus, T Walters, WH Wan Mohamad, L Wang, W Wang, X Wang, X Wang, Y Wang, C Wanner, S Wanninayake, H Watada, K Watanabe, K Watanabe, M Watanabe, H Waterfall, D Watkins, S Watson, L Weaving, B Weber, Y Webley, A Webster, M Webster, M Weetman, W Wei, H Weihprecht, L Weiland, J Weinmann-Menke, T Weinreich, R Wendt, Y Weng, M Whalen, G Whalley, R Wheatley, A Wheeler, J Wheeler, P Whelton, K White, B Whitmore, S Whittaker, J Wiebel, J Wiley, L Wilkinson, M Willett, A Williams, E Williams, K Williams, T Williams, A Wilson, P Wilson, L Wincott, E Wines, B Winkelmann, M Winkler, B Winter-Goodwin, J Witczak, J Wittes, M Wittmann, G Wolf, L Wolf, R Wolfling, C Wong, E Wong, HS Wong, LW Wong, YH Wong, A Wonnacott, A Wood, L Wood, H Woodhouse, N Wooding, A Woodman, K Wren, J Wu, P Wu, S Xia, H Xiao, X Xiao, Y Xie, C Xu, Y Xu, H Xue, H Yahaya, H Yalamanchili, A Yamada, N Yamada, K 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The Lancet Diabetes & Endocrinology 12 ( 1 ) 39 - 50 2024.1

Impact of primary kidney disease on the effects of empagliflozin in patients with chronic kidney disease: secondary analyses of the EMPA-KIDNEY trial Reviewed

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Talsania, Y Tamori, R Tamura, Y Tamura, CHH Tan, EZZ Tan, A Tanabe, K Tanabe, A Tanaka, A Tanaka, N Tanaka, S Tang, Z Tang, K Tanigaki, M Tarlac, A Tatsuzawa, JF Tay, LL Tay, J Taylor, K Taylor, K Taylor, A Te, L Tenbusch, KS Teng, A Terakawa, J Terry, ZD Tham, S Tholl, G Thomas, KM Thong, D Tietjen, A Timadjer, H Tindall, S Tipper, K Tobin, N Toda, A Tokuyama, M Tolibas, A Tomita, T Tomita, J Tomlinson, L Tonks, J Topf, S Topping, A Torp, A Torres, F Totaro, P Toth, Y Toyonaga, F Tripodi, K Trivedi, E Tropman, D Tschope, J Tse, K Tsuji, S Tsunekawa, R Tsunoda, B Tucky, S Tufail, A Tuffaha, E Turan, H Turner, J Turner, M Turner, KR Tuttle, YL Tye, A Tyler, J Tyler, H Uchi, H Uchida, T Uchida, T Uchida, T Udagawa, S Ueda, Y Ueda, K Ueki, S Ugni, E Ugwu, R Umeno, C Unekawa, K Uozumi, K Urquia, A Valleteau, C Valletta, R van Erp, C Vanhoy, V Varad, R Varma, A Varughese, P Vasquez, A Vasseur, R Veelken, C Velagapudi, K Verdel, S Vettoretti, G Vezzoli, V Vielhauer, R Viera, E Vilar, S Villaruel, L Vinall, J Vinathan, M Visnjic, E Voigt, M von-Eynatten, M Vourvou, J Wada, J Wada, T Wada, Y Wada, K Wakayama, Y Wakita, K Wallendszus, T Walters, WH Wan Mohamad, L Wang, W Wang, X Wang, X Wang, Y Wang, C Wanner, S Wanninayake, H Watada, K Watanabe, K Watanabe, M Watanabe, H Waterfall, D Watkins, S Watson, L Weaving, B Weber, Y Webley, A Webster, M Webster, M Weetman, W Wei, H Weihprecht, L Weiland, J Weinmann-Menke, T Weinreich, R Wendt, Y Weng, M Whalen, G Whalley, R Wheatley, A Wheeler, J Wheeler, P Whelton, K White, B Whitmore, S Whittaker, J Wiebel, J Wiley, L Wilkinson, M Willett, A Williams, E Williams, K Williams, T Williams, A Wilson, P Wilson, L Wincott, E Wines, B Winkelmann, M Winkler, B Winter-Goodwin, J Witczak, J Wittes, M Wittmann, G Wolf, L Wolf, R Wolfling, C Wong, E Wong, HS Wong, LW Wong, YH Wong, A Wonnacott, A Wood, L Wood, H Woodhouse, N Wooding, A Woodman, K Wren, J Wu, P Wu, S Xia, H Xiao, X Xiao, Y Xie, C Xu, Y Xu, H Xue, H Yahaya, H Yalamanchili, A Yamada, N Yamada, K Yamagata, M Yamaguchi, Y Yamaji, A Yamamoto, S Yamamoto, S Yamamoto, T Yamamoto, A Yamanaka, T Yamano, Y Yamanouchi, N Yamasaki, Y Yamasaki, Y Yamasaki, C Yamashita, T Yamauchi, Q Yan, E Yanagisawa, F Yang, L Yang, S Yano, S Yao, Y Yao, S Yarlagadda, Y Yasuda, V Yiu, T Yokoyama, S Yoshida, E Yoshidome, H Yoshikawa, A Young, T Young, V Yousif, H Yu, Y Yu, K Yuasa, N Yusof, N Zalunardo, B Zander, R Zani, F Zappulo, M Zayed, B Zemann, P Zettergren, H Zhang, L Zhang, L Zhang, N Zhang, X Zhang, J Zhao, L Zhao, S Zhao, Z Zhao, H Zhong, N Zhou, S Zhou, D Zhu, L Zhu, S Zhu, M Zietz, M Zippo, F Zirino, FH Zulkipli

The Lancet Diabetes & Endocrinology 12 ( 1 ) 51 - 60 2024.1

Review of a Series of Surveys on Adverse Reactions to the COVID-19 mRNA-1273 Vaccine at Okayama University. Reviewed

Naomi Matsumoto, Chigusa Higuchi, Chikara Miyaji, Toshiharu Mitsuhashi, Hideharu Hagiya, Soshi Takao, Takashi Yorifuji

Acta medica Okayama 77 ( 6 ) 567 - 575 2023.12

Language：English Publishing type：Research paper (scientific journal)

This paper presents the results of a series of surveys conducted from July 2021 to March 2023 to investigate the post-vaccination adverse reactions to the mRNA-1273 (Moderna) vaccine among faculty, staff, and students at Okayama University. These studies complement the official surveys conducted by the Ministry of Health, Labour and Welfare (MHLW) and provide a more representative picture of adverse reactions in the general population including large numbers of healthy young people. Pain, swelling, redness at the injection site, fever, headache, and malaise were the main adverse reactions reported. The proportion of adverse reactions was generally higher after the second vaccination and decreased with each additional vaccination. No statistically significant differences in the adverse reactions were found for males and females and those with/without a history of allergy, but a lower proportion of fever was observed in older participants and those with underlying medical conditions. We also evaluated the association between adverse reactions and antibody titers after the third vaccination and found no significant differences in antibody levels one month after vaccination. This series of studies highlights the importance of conducting surveys in diverse populations to provide a more representative picture of post-vaccination adverse reactions during a pandemic.

DOI： 10.18926/AMO/66148

PubMed

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Initial Two Doses of COVID-19 Vaccine mRNA-1273 for an Individual Previously Vaccinated with Two Doses of an Inactivated Vaccine CoronaVac That Has Not Been Approved in Japan Reviewed

Yoshiaki Iwasaki, Chigusa Higuchi

77 ( 1 ) 105 - 109 2023.2

Empagliflozin in Patients with Chronic Kidney Disease Reviewed

New England Journal of Medicine 388 ( 2 ) 117 - 127 2023.1

Association between fever and antibody titer trends after a third dose of the mRNA-1273 vaccine. Reviewed

Naomi Matsumoto, Tomoka Kadowaki, Rumi Matsuo, Ayako Sasaki, Chikara Miyaji, Chigusa Higuchi, Masanori Nakayama, Yasue Sakurada, Hideharu Hagiya, Soshi Takao, Fumio Otsuka, Takashi Yorifuji

Journal of epidemiology 32 ( 12 ) 567 - 569 2022.8

Adverse reactions and attitudes toward vaccines among young populations one month after receiving a second dose of mRNA-1273 in Japan. Reviewed

Naomi Matsumoto, Chigusa Higuchi, Toshiharu Mitsuhashi, Hideharu Hagiya, Soshi Takao, Takashi Yorifuji

Global health & medicine 4 ( 2 ) 141 - 143 2022.4

Language：English Publishing type：Research paper (scientific journal)

To investigate adverse reactions and attitudes toward the vaccine during the first month after mRNA- 1273 vaccination in a larger sample including younger men and women in Japan, we distributed a 1-month post-vaccination questionnaire using a Google form to 8,566 people who received a second dose of mRNA-1273 at Okayama University. The response rate was about 40.2% (3,447 responses), the sex ratio was about the same, and 73.3 % (2,528 respondents) were students in their twenties or younger. Poisson regression with robust variance was performed to calculate the prevalence ratio of each symptom by different attributes. The most common adverse reactions after the second vaccine dose were local pain (80.4%), fever (85.1%), malaise (82.0%), headache (64.0%), and chills (57.4%). Approximately 99% of respondents reported that their adverse reactions resolved within 1 week. Over 80% of respondents were satisfied with their vaccination (87.2%), expressed interest in receiving the third vaccination (83.3%), and would recommend vaccination to their loved ones (80.2%). However, among them, 22.0% (757 respondents) would recommend and 28.4% (980 respondents) also stated that they would consider the type of vaccine in these decisions.

DOI： 10.35772/ghm.2021.01125

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Questionnaire Survey on COVID-19 Vaccination at Okayama University in Japan: Factors Promoting Vaccination Among Young Adults Reviewed

Chigusa Higuchi, Naomi Matsumoto, Yoshiaki Iwasaki, Takashi Yorifuji, Junichiro Yamazaki, Yasutomo Nasu, Hirofumi Makino

Journal of Disaster Research 17 ( 1 ) 21 - 30 2022.1

Authorship：Lead author Publishing type：Research paper (scientific journal) Publisher：Fuji Technology Press Ltd.

COVID-19 has been prevalent worldwide since 2019. Increasing COVID-19 vaccination coverage is an important measure to combat the disease. An online survey was conducted with university students and personnel who were vaccinated against COVID-19 at a mass vaccination event to examine the factors promoting vaccination among young adults. The online survey was conducted with persons vaccinated at Okayama University from June 5 to September 27, 2021. Although the number of those who had fever >37.5°C increased after the second vaccination compared to the first, the vaccinated persons got more satisfied after the second shot.

DOI： 10.20965/jdr.2022.p0021

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Circulating GPIHBP1 levels and microvascular complications in patients with type 2 diabetes: A cross-sectional study. Reviewed International journal

Naoko Kurooka, Jun Eguchi, Kazutoshi Murakami, Shinji Kamei, Toru Kikutsuji, Sakiko Sasaki, Akiho Seki, Satoshi Yamaguchi, Ichiro Nojima, Mayu Watanabe, Chigusa Higuchi, Akihiro Katayama, Haruhito A Uchida, Atsuko Nakatsuka, Kenichi Shikata, Jun Wada

Journal of clinical lipidology 16 ( 2 ) 237 - 245 2022.1

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1 (GPIHBP1) plays a crucial role in lipolytic processing. Previous studies have shown that GPIHBP1 mutations cause severe hypertriglyceridemia and that serum GPIHBP1 levels are marginally higher in patients with coronary heart disease; however, the role of GPIHBP1 in type 2 diabetes mellitus (T2DM) remains unknown. OBJECTIVE: We investigated the association between circulating GPIHBP1 levels and the prevalence of microvascular complications in T2DM. METHODS: A total of 237 subjects with T2DM and 235 non-diabetic control subjects were enrolled in this study. Their serum GPIHBP1 levels were evaluated using ELISA assays. RESULTS: Circulating GPIHBP1 levels were higher in patients with T2DM (952.7 pg/mL [761.3-1234.6], p < 0.0001) than in non-diabetic subjects (700.6 [570.8-829.6]), but did not differ in T2DM patients with or without hypertriglyceridemia. Serum GPIHBP1 levels were significantly higher in patients with T2DM with diabetic retinopathy (DR), diabetic nephropathy (DN), and microvascular complications than in those without these complications. Multivariable logistic regression and receiver operating characteristic (ROC) curve analyses revealed that the presence of microvascular complications, but not macrovascular complications, was independently associated with serum GPIHBP1 levels, which could predict the presence of diabetic microvascular complications. CONCLUSIONS: Elevated GPIHBP1 levels are associated with microvascular complications in T2DM and may help to predict their progression.

DOI： 10.1016/j.jacl.2022.01.006

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インスリン抵抗性/肥満肥満・2型糖尿病におけるmir221/222の機能解析 Reviewed

山口哲志, 片山晶博, 樋口千草, 中司敦子, 江口潤, 和田淳

糖尿病合併症 35 ( Suppl. ) 237 - 237 2021.9

インスリン抵抗性/肥満食負荷肥満マウスと視床下部食欲制御マウスにおけるMir342発現上昇(Upregulation of Mir342 in diet-induced obesity mouse and the hypothalamic appetite control) Reviewed

張冬曉, 山口哲志, 樋口千草, 中司敦子, 江口潤, 和田淳

糖尿病合併症 35 ( Suppl. ) 239 - 239 2021.9

Novel Urinary Glycan Biomarkers Predict Cardiovascular Events in Patients With Type 2 Diabetes: A Multicenter Prospective Study With 5-Year Follow Up (U-CARE Study 2) Reviewed International journal

Koki Mise, Mariko Imamura, Satoshi Yamaguchi, Mayu Watanabe, Chigusa Higuchi, Akihiro Katayama, Satoshi Miyamoto, Haruhito A. Uchida, Atsuko Nakatsuka, Jun Eguchi, Kazuyuki Hida, Tatsuaki Nakato, Atsuhito Tone, Sanae Teshigawara, Takashi Matsuoka, Shinji Kamei, Kazutoshi Murakami, Ikki Shimizu, Katsuhiro Miyashita, Shinichiro Ando, Tomokazu Nunoue, Michihiro Yoshida, Masao Yamada, Kenichi Shikata, Jun Wada

Frontiers in Cardiovascular Medicine 8 668059 - 668059 2021.5

Language：English Publishing type：Research paper (scientific journal) Publisher：Frontiers Media SA

<bold>Background:</bold> Although various biomarkers predict cardiovascular event (CVE) in patients with diabetes, the relationship of urinary glycan profile with CVE in patients with diabetes remains unclear.

<bold>Methods:</bold> Among 680 patients with type 2 diabetes, we examined the baseline urinary glycan signals binding to 45 lectins with different specificities. Primary outcome was defined as CVE including cardiovascular disease, stroke, and peripheral arterial disease.

<bold>Results:</bold> During approximately a 5-year follow-up period, 62 patients reached the endpoint. Cox proportional hazards analysis revealed that urinary glycan signals binding to two lectins were significantly associated with the outcome after adjustment for known indicators of CVE and for false discovery rate, as well as increased model fitness. Hazard ratios for these lectins (+1 SD for the glycan index) were UDA (recognizing glycan: mixture of Man5 to Man9): 1.78 (95% CI: 1.24–2.55, <italic>P</italic> = 0.002) and Calsepa [High-Man (Man2–6)]: 1.56 (1.19–2.04, <italic>P</italic> = 0.001). Common glycan binding to these lectins was high-mannose type of <italic>N</italic>-glycans. Moreover, adding glycan index for UDA to a model including known confounders improved the outcome prediction [Difference of Harrel's C-index: 0.028 (95% CI: 0.001–0.055, <italic>P</italic> = 0.044), net reclassification improvement at 5-year risk increased by 0.368 (0.045–0.692, <italic>P</italic> = 0.026), and the Akaike information criterion and Bayesian information criterion decreased from 725.7 to 716.5, and 761.8 to 757.2, respectively].

<bold>Conclusion:</bold> The urinary excretion of high-mannose glycan may be a valuable biomarker for improving prediction of CVE in patients with type 2 diabetes, and provides the rationale to explore the mechanism underlying abnormal <italic>N</italic>-glycosylation occurring in patients with diabetes at higher risk of CVE.

<bold>Trial Registration:</bold> This study was registered with the University Hospital Medical Information Network on June 26, 2012 (Clinical trial number: UMIN000011525, URL: <ext-link>https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000013482</ext-link>).

DOI： 10.3389/fcvm.2021.668059

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当院におけるTime-In-Range(TIR)とHbA1cとの関連についての検討 Reviewed

片山晶博, 野島一郎, 樋口千草, 渡邉真由, 宮本聡, 中司敦子, 江口潤, 四方賢一, 和田淳

糖尿病 63 ( Suppl.1 ) S - 220 2020.8

学生の非アルコール性脂肪性肝疾患における遺伝的素因の検討

岩崎良章, 中山光, 森田知子, 岡香織, 樋口千草, 二宮崇, 黒木清美, 中西順子, 山際陽子, 影山真希, 古本友理, 内藤惠子, 河原宏子, 岡部伸幸, 大西勝

CAMPUS HEALTH 57 ( 1 ) 63 - 63 2020.3

社会保険労務士との協働によるメンタルヘルス支援

兒山志保美, 大西勝, 河原宏子, 岡部伸幸, 中西順子, 岡香織, 黒木清美, 樋口千草, 二宮崇, 岩崎良章

CAMPUS HEALTH 57 ( 1 ) 271 - 272 2020.3

留学生定期健康診断における胸部X線検査所見の検討

二宮崇, 山際陽子, 岡香織, 黒木清美, 古本友理, 内藤惠子, 影山真希, 樋口千草, 河原宏子, 岡部伸幸, 大西勝, 岩崎良章

CAMPUS HEALTH 57 ( 1 ) 335 - 337 2020.3

Language：Japanese Publisher：(公社)全国大学保健管理協会

本学では留学生を積極的に受け入れる方針としており、最近5年間で増加している。今回、2014〜2018年度に入学し定期健診で胸部X線検査を受けた留学生のべ3107名のX線所見を調査し、経年的変化について検討した。各年度の有所見者割合は7.0〜18.5%でバラツキがあり、2016年度が最も高かった。要精査率は2.2〜4.0%で年度間の大差は認めなかった。結核高負担国からの留学生と高負担国以外からの留学生とで有所見率を比較すると、高負担国以外のほうがやや高く、要精査率についても同様であった。有所見や要精査と判定された部位を高負担国と高負担国以外で比較すると、高負担国では肺や心臓の占める割合が高く、高負担国以外では肺や心臓の占める割合は高負担国ほどではなく、椎骨の占める割合が高かった。

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インスリンポンプ療法からSAP療法への治療変更効果に関する後ろ向き観察研究 Reviewed

山口哲志, 利根淳仁, 勅使川原早苗, 渡邊真由, 片山晶博, 宮本聡, 江口潤, 中司敦子, 樋口千草, 小川大輔, 四方賢一, 和田淳

糖尿病 62 ( 5 ) 315 - 321 2019.5

Language：Japanese Publisher：(一社)日本糖尿病学会

本研究はSAP導入後の効果を検討するため、CSIIからSAPに変更後1年以上経過した1型糖尿病22症例を解析した後ろ向き観察研究である。HbA1cはSAP前と比較して6ヵ月(6M)では不変、12Mで有意に低下した(各々7.6±0.7%、7.4±0.9%、7.1±0.9%)。6Mの時点でHbA1c0.1%以上低下した群を6M低下群、変化なし又は0.1%以上上昇した群を6M不変・上昇群と定義したところ、6M不変・上昇群で0MのHbA1cが有意に低値で、重回帰分析では基礎インスリン比率の変化(6M)がHbA1c変化量(6M)の有意な決定因子として採用され、負の相関を示した。また、6M不変・上昇群では0MのSMBGで低血糖頻度が有意に高く、1Mで有意に低下した。臨床的にSMBGでの低血糖が多い症例ではSAP導入後にHbA1c上昇を呈す事もあり、注意を要する。(著者抄録)

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J00926&link_issn=&doc_id=20190603330001&doc_link_id=10.11213%2Ftonyobyo.62.315&url=https%3A%2F%2Fdoi.org%2F10.11213%2Ftonyobyo.62.315&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

医療系学生における入学時HBs抗体陽性者の実態と対応についての検討

岩崎良章, 黒木清美, 中西順子, 山際陽子, 岡香織, 影山真希, 古本友理, 森田知子, 内藤惠子, 樋口千草, 二宮崇, 河原宏子, 清水幸登, 大西勝

CAMPUS HEALTH 56 ( 1 ) 271 - 271 2019.3

医療系留年学生への対応について教務担当教員・事務との合同面談

大西勝, 兒山志保美, 福永実加, 中西順子, 岡香織, 黒木清美, 樋口千草, 二宮崇, 河原宏子, 清水幸登, 岩崎良章

CAMPUS HEALTH 56 ( 1 ) 366 - 367 2019.3

A retrospective observational study on the effects of switching from conventional insulin pump to sensor-augmented pump (SAP) therapy Reviewed

Satoshi Yamaguchi, Atsuhito Tone, Sanae Teshigawara, Mayu Watanabe, Akihiro Katayama, Satoshi Miyamoto, Jun Eguchi, Atsuko Nakatsuka, Chigusa Higuchi, Daisuke Ogawa, Kenichi Shikata, Jun Wada

Journal of the Japan Diabetes Society 62 ( 5 ) 315 - 321 2019

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Diabetes Society

The purpose of this retrospective observational study is to analyze the clinical course of sensor augmented pump (SAP) therapy after switching from insulin pump therapy and to evaluate the predictors of the therapeutic effects of SAP therapy. Twenty-two type 1 diabetes patients who received SAP therapy for more than one year after switching from insulin pump therapy were enrolled. HbAlc levels were unchanged at 6 months and significantly improved at 12 months. The HbAlc levels at 6 months were decreased in 14 patients and unchanged or increased in the other 8 patients. In the latter group with unchanged or increased HbAlc levels at 6 months, the mean HbAlc level at the induction of SAP therapy was significantly lower and the percentage of patients with SMBG &lt
70 mg/dL before SAP therapy was higher in comparison to the former group. A multiple regression analysis showed a significant negative correlation between the change in % TBD (6M) and the change in the HbAlc level (6M). Conclusively, in patients with frequent hypoglycemia, we should evaluate the therapeutic effects based on various parameters, such as average sensor glucose levels and AUC &lt
70 mg/dL, since it is possible that the HbAlc level may transiently increase after the induction of SAP therapy in such cases.

DOI： 10.11213/tonyobyo.62.315

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医療系留年学生への対応について教務担当教員・事務との合同面談

大西勝, 兒山志保美, 福永実加, 中西順子, 岡香織, 黒木清美, 樋口千草, 二宮崇, 河原宏子, 清水幸登, 岩崎良章

全国大学保健管理研究集会プログラム・抄録集 56回 98 - 98 2018.9

大学新入生が抱える不安への一次予防全新入生ガイダンスにおける無記名アンケート結果から

清水幸登, 福永実加, 影山真希, 河原宏子, 兒山志保美, 大西勝, 谷口暁彦, 樋口千草, 岩崎良章

CAMPUS HEALTH 55 ( 2 ) 144 - 149 2018.5

Language：Japanese Publisher：(公社)全国大学保健管理協会

新入生が学生生活に良好に適応していくためには、大学や教職員がどのような配慮をすればよいかを探る目的で、新入生への無記名アンケートを実施した。調査対象は2017年度岡山大学の全新入生で、そのうち2051名(回収率90.4%)の回答を得た。入学後に不安を感じる事柄は、勉強面76.0%、人間関係43.8%、生活一般23.0%であった。勉強面で不安なことは、学力面53.1%、履修登録37.6%、部活動との兼ね合い23.5%であった。履修登録では、授業選択が困難63.8%、履修登録制度が判りにくい31.7%、web入力が困難12.7%であった。自力で履修登録ができた者は45.2%であった。パソコンが苦手・少し苦手な学生は78.1%であった。人前で話すことが苦手な学生の割合は37.7%であり、人前で話すことが苦手でない学生に比べて、勉強面への不安を持つものが有意に多かった。今回の調査結果から、新入生には、勉強面での不安を感じている学生が圧倒的に多いことが判明した。勉強面において、履修登録の教職員側からのさらなる支援、パソコン習熟授業の必修科目化、人前で話すことが苦手な学生を援助機関に繋げる啓発活動と合わせて授業内での教職員の配慮は、新入生のメンタルヘルス不調の発生を抑制すると推測された。このように新入生へのメンタルヘルスの講義と並行して、就学環境・システムに対する働きかけが、メンタルヘルス一次予防にとって重要であると考える。(著者抄録)

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当院における免疫チェックポイント阻害薬による副作用(耐糖能異常および甲状腺機能異常)の検討 Reviewed

渡邉真由, 有木沙織, 山口哲志, 樋口千草, 勅使川原早苗, 宮本聡, 利根淳仁, 中司敦子, 江口潤, 四方賢一, 和田淳

糖尿病 61 ( Suppl.1 ) S - 255 2018.4

研修医へのメンタルヘルス支援卒後研修センターとの連携

兒山志保美, 大西勝, 中西順子, 古本友里, 岡香織, 黒木清美, 樋口千草, 谷口暁彦, 河原宏子, 清水幸登, 岩崎良章

CAMPUS HEALTH 55 ( 1 ) 389 - 391 2018.3

健康診断システムの更新について

山際陽子, 影山真希, 岡香織, 古本友理, 黒木清美, 樋口千草, 谷口暁彦, 河原宏子, 清水幸登, 大西勝, 岩崎良章

CAMPUS HEALTH 55 ( 1 ) 80 - 81 2018.3

医療系学生における定期インターフェロンγ遊離試験の検査法と陽性率についての検討

谷口暁彦, 樋口千草, 中山光, 古本友理, 山際陽子, 岡香織, 黒木清美, 河原宏子, 清水幸登, 大西勝, 岩崎良章

CAMPUS HEALTH 55 ( 1 ) 241 - 243 2018.3

Language：Japanese Publisher：(公社)全国大学保健管理協会

本学では医療系学生全員に対し、臨床実習開始前に定期検査としてインターフェロンγ遊離試験を実施している。試験方法は、2007〜2010年度はクォンティフェロンTB-2Gを使用し、2011年度、2012年度、2016年度はクォンティフェロンTBゴールド(QFT-3G)、2013〜2015年度はTスポットTB(T-SPOT)を使用した。今回、QFT-3Gを使用した年度とT-SPOTを使用した年度とで陽性率や事後措置を比較検討した。結果、QFT-3GはT-SPOTに比べて陽性および判定保留の頻度が有意に高かった。ただしQFT-3Gは陽性率・判定保留率とも年度による差が大きいことから、結果の解釈に注意を要すると考えられた。

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新入生が抱える不安全学新入生ガイダンスにおける無記名アンケートから

清水幸登, 福永実加, 影山真希, 河原宏子, 兒山志保美, 大西勝, 谷口暁彦, 樋口千草, 岩崎良章

CAMPUS HEALTH 55 ( 1 ) 381 - 381 2018.3

研修医へのメンタルヘルス支援卒後研修センターとの連携

兒山志保美, 大西勝, 中西順子, 古本友里, 岡香織, 黒木清美, 樋口千草, 谷口暁彦, 河原宏子, 清水幸登, 岩崎良章

全国大学保健管理研究集会プログラム・抄録集 55回 115 - 115 2017.11

SAP療法の治療反応性を予見する患者像の検討 Reviewed

利根淳仁, 勅使川原早苗, 宮本聡, 江口潤, 中司敦子, 樋口千草, 小川大輔, 四方賢一, 和田淳

糖尿病 60 ( Suppl.1 ) S - 390 2017.4

Pemt Deficiency Ameliorates Endoplasmic Reticulum Stress in Diabetic Nephropathy Reviewed

Mayu Watanabe, Atsuko Nakatsuka, Kazutoshi Murakami, Kentaro Inoue, Takahiro Terami, Chigusa Higuchi, Akihiro Katayama, Sanae Teshigawara, Jun Eguchi, Daisuke Ogawa, Eijiro Watanabe, Jun Wada, Hirofumi Makino

PLOS ONE 9 ( 3 ) e92647 2014.3

Language：English Publishing type：Research paper (scientific journal) Publisher：PUBLIC LIBRARY SCIENCE

Phosphatidylethanolamine N-methyltransferase (Pemt) catalyzes the methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) mainly in the liver. Under an obese state, the upregulation of Pemt induces endoplasmic reticulum (ER) stress by increasing the PC/PE ratio in the liver. We targeted the Pemt gene in mice to explore the therapeutic impact of Pemt on the progression of diabetic nephropathy and diabetes, which was induced by the injection of streptozotocin (STZ). Although the blood glucose levels were similar in STZ-induced diabetic Pemt+/+ and Pemt-/-mice, the glomerular hypertrophy and albuminuria in Pemt-/- mice were significantly reduced. Pemt deficiency reduced the intraglomerular F4/80-positive macrophages, hydroethidine fluorescence, tubulointerstitial fibrosis and tubular atrophy. The expression of glucose-regulated protein-78 (GRP78) was enriched in the renal tubular cells in STZ-induced diabetic mice, and this was ameliorated by Pemt deficiency. In mProx24 renal proximal tubular cells, the treatment with ER-stress inducers, tunicamycin and thapsigargin, increased the expression of GRP78, which was reduced by transfection of a shRNA lentivirus for Pemt (shRNA-Pemt). The number of apoptotic cells in the renal tubules was significantly reduced in Pemt-/- diabetic mice, and shRNA-Pemt upregulated the phosphorylation of Akt and decreased the cleavage of caspase 3 and 7 in mProx24 cells. Taken together, these findings indicate that the inhibition of Pemt activity ameliorates the ER stress associated with diabetic nephropathy in a model of type 1 diabetes and corrects the functions of the three major pathways downstream of ER stress, i.e. oxidative stress, inflammation and apoptosis.

DOI： 10.1371/journal.pone.0092647

Web of Science

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Serum galectin-9 levels are elevated in the patients with type 2 diabetes and chronic kidney disease Reviewed

Kurose Yuko, Wada Jun, Kanzaki Motoko, Teshigawara Sanae, Nakatsuka Atsuko, Murakami Kazutoshi, Inoue Kentaro, Terami Takahiro, Katayama Akihiro, Watanabe Mayu, Higuchi Chigusa, Eguchi Jun, Miyatake Nobuyuki, Makino Hirofumi

BMC Nephrology 14 2013.1

肥満症におけるGpnmbの意義 Reviewed

片山晶博, 和田淳, 中司敦子, 江口潤, 村上和敏, 神崎資子, 勅使川原早苗, 井上謙太郎, 寺見隆宏, 渡邉真由, 樋口千草, 肥田和之, 四方賢一, 槇野博史

肥満研究 18 ( Suppl. ) 156 - 156 2012.9

Comparison of Insulin Detemir and Insulin Glargine on Glycemic Variability in Patients with Type 1 and Type 2 Diabetes Reviewed

Tone A, Iseda I, Higuchi C, Tsukamoto K, Katayama A, Matsushita Y, Hida K, Wada J, Shikata K

Experimental and Clinical Endocrinology & Diabetes 118 ( 5 ) 320 - 324 2010

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